4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
molecule tags Hydrolase
source organism Streptococcus pyogenes
molecule keywords Streptopain
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
2JTCA 2UZJA 4D8IA 3BBAA 3BB7A 4D8BA 4D8EA 1PVJA 4RKXA 1DKIA
chains in the Genus database with same CATH superfamily
4OVZA 2R9FA 5EZQA 1PVJA 5FPWA 3S3QA 3ZUAA 1MHWA 1CSBB 1YK8A 2WBFX 5CHTA 1AU2A 2DCBA 2VHSA 1STFE 3OVZA 5CVNB 2OP3A 3BB7A 1HUCB 2DC9A 2F7DA 1PPPA 4MZSA 4BOSA 2R9NA 4BOPA 1BY8A 4BSQA 2PREA 1AU0A 2HWKA 4X6JA 2CB5A 3WXGA 4BQVA 3QSDA 1BP4A 1CJLA 2FRQA 4PP1A 3CBJA 3F5VA 4QRXA 4Q8GA 6PADA 4WA6A 1CTEA 2E03A 3HHIA 2DZYA 2AUXA 3RVVA 4BS6A 5E6JA 2YJ2A 1BGOA 2E02A 1ME3A 1S4VA 3S3RA 1PADA 3CH3X 3N4CA 3PRMA 3USVA 2DC6A 2XU4A 2FRAA 3IOQA 1PCIA 3PNRA 4AXMA 3B21A 3BBAA 5EZSA 4YYVA 1EWPA 1VSNA 4ZTBA 1JQPA 3WXFA 1AYVA 2JQFR 1NPZA 4YYRA 4D8EA 3P5XA 4KLBA 2DZZA 3AI8A 4P6EA 4RF1A 1AYUA 4G54A 4BOZA 3D6SA 1K3BB 2R6NA 1FH0A 3DF0A 4DMYA 4QRGA 2AVWA 4CDEB 1DKIA 2FUDA 4WURA 1KFUL 3C0RA 5CHVA 4BPVA 4PADA 1EF7A 2P7UA 2J7QA 3H7DA 2Y6EA 3HHAA 3OF8A 1MIRA 2FYEA 4D8IA 1DF0A 5K16A 5CVOB 2VHFA 2FO5A 3PW3A 1AIMA 3MHHA 1KHQA 3OISA 1A6RA 3K24A 3IUTA 3I3TA 2HXZA 1U9WA 2DJGB 2R9MA 4BS5A 3E1ZB 2JTCA 4XZXA 2PBHA 3N3KA 1Y4HA 3PHUA 1VJVA 3C9EA 1POPA 1SNKA 1Q6KA 1CS8A 4YYUA 2DC8A 2R9CA 2XU1A 2B1NA 1AU4A 2BU3A 1PPNA 3KX1A 2PADA 9PAPA 5J94A 1YT7A 1PPOA 1KXRA 1TL9A 2H7JA 2ATOA 3H8BA 2DOSA 4RF0A 3WXEA 2YJ9A 1MDWA 4P16A 3F75A 3TMPA 3V6CA 1NB5A 3O0UA 1AECA 4QRVA 3O1GA 2JRIA 1U9VA 3OVXA 1CQDA 3OQCA 1TLOA 2NQGA 2HH5A 3MP2A 4CDDB 1PBHA 4D8BA 4PP2E 3BOWA 2PNSA 3P5WA 2HD5A 1ATKA 2OZ2A 2BTWB 1BQIA 4XR7A 3KWZA 1ZIVA 4CDFB 3PRPA 2DCCA 3IEJA 2UZJA 1YALA 3GCBA 1ZCMA 1DEUA 4OEMA 4FJCA 4W5BA 2R9OA 4IUMA 4QBBA 1KHPA 2DCAA 1QXPA 2ACTA 3K8UA 3I06A 2FE8A 2FTDA 1SP4B 3ERVA 4QH6A 1PXVA 5KO3A 2AIMA 1TU6A 3HD3A 3ZNHA 3LFYA 2AYNA 2YJBA 4N79A 2AS8A 3QJ3A 2JQGR 4M0WA 3W30A 4RY2A 1XKGA 1QOLA 1EWOA 3O65A 3MTNA 1QMYA 1IWDA 1CVZA 1U9XA 1NL6A 4W4UA 4OW0A 5A24A 4ZUXU 2G8EA 4R3DA 1F2BA 4BOQA 2F1GA 1NB3A 2AU1A 2AUZA 4REZA 2C0YA 3PHXA 3BCNA 3TNXA 3QT4A 2XU3A 3TRKA 4HWYA 1F2AA 1YZBA 4OELA 4RKXA 4MM3B 4GUAA 2G6DA 3IFUA 3IMAA 3LXSA 2BTWA 4MI7A 3PSEA 2Z84A 5F02A 4Q8HA 4IP3A 3M99A 1ICFA 4CDCB 1ME4A 4K7CA 4N8WA 1MS6A 3PDFA 2BDLA 2DJFB 5CVMA 1YVBA 2J7QC 4YYQA 2IPPB 3MTVA 3CH2X 3IV2A 1UKFA 1PPDA 2GFOA 1PIPA 4FIPA 4X6HA 2YJCA 2XU5A 4AXLA 3OF9A 3BC3A 1M6DA 4PT5A 3H8CA 1GCBA 2BDZA 3KSEA 4FK5A 2E00A 1X9YA 2O6XA 1PE6A 2GHUA 1CB5A 4OVZB 2OULA 2IBIA 7PCKA 3KFQA 4YYSA 3BPMA 3U8EA 5EGWA 5JZEA 2ARYA 2NQDB 3BWKA 4X6IA 4YV8A 1CPJA 3PBHA 1MEMA 4BOUA 4HXDB 2DC7A 4XUIA 8PCHA 1YK7A 4CZWA 3P5UA 3RVXA 3K9MA 3PT2A 3RVWA 4MZOA 2B1MA 1EWLA 3B79A 1U9QX 3CBKA 1CV8A 3MJ5A 4I07A 1F2CA 3P5VA 2YJ8A 2AYOA 4P6GA 3PHWA 4I04A 1GECE 3IHPA 3HWNA 2P86A 3H89A 2P0RA 3H6SA 1QDQA 1O0EA 5JH3A 4I05A 1AU3A 1KFXL 3BPFA 4DMXA 1U5IA 1NLJA 1EWMA 5EF4A 4YYWA 4MSXA 4W5CA 2NQIA 1MEGA 2FT2A 5JA7A 4N4ZA 4RNAA 1NQCA 4PI3A 3N3GA 3W31A 1ITOA 2FQ9A 3MORA 3RNVA 1GLOA 2DCDA 2AGAA 3E9SA 1F29A 2HHNA 4A5UA 2CIOA 3KWBX 1GMYA 2NQAA 1Y08A 2G7YA 3BY4A 1AYWA 5PADA 3KKUA 4YVAA 3MHSA 2G8JA 2E01A 3KW9A 2Y5BA 3V6EA 1THEA 3NHEA
chains in the Genus database with same CATH topology
4OVZA 2FE8A 4PT5A 5EZQA 1PVJA 2J7QA 4D8IA 5KO3A 3ZNHA 4OVZB 3BB7A 4M0WA 5JZEA 3W30A 4BOSA 4BOPA 2JTCA 4XZXA 2HWKA 4BOUA 3O65A 3PHUA 4HXDB 3PT2A 3MJ5A 2BU3A 3PHWA 4OW0A 5E6JA 4R3DA 4BOQA 2DOSA 4RF0A 4REZA 4P16A 3PHXA 3TMPA 3TRKA 3PRMA 2JRIA 1YZBA 4RKXA 4MM3B 3B21A 3OQCA 4GUAA 3BBAA 3IFUA 5EZSA 2BTWA 4ZTBA 4MI7A 4RNAA 3PSEA 2Z84A 3MP2A 4D8BA 3W31A 4IP3A 3RNVA 4D8EA 2AGAA 3E9SA 4A5UA 2BTWB 4RF1A 2J7QC 3PRPA 3BY4A 3MTVA 4BOZA 2UZJA 1UKFA 1DKIA 4IUMA 4WURA 3C0RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JTC A;  2UZJ A;  4D8I A;  3BBA A;  3BB7 A;  4D8B A;  4D8E A;  1PVJ A;  4RKX A;  1DKI A; 
#chains in the Genus database with same CATH topology
 4OVZ A;  2R9F A;  5EZQ A;  1PVJ A;  5FPW A;  3S3Q A;  3ZUA A;  1MHW A;  1CSB B;  1YK8 A;  2WBF X;  5CHT A;  1AU2 A;  2DCB A;  2VHS A;  1STF E;  3OVZ A;  5CVN B;  2OP3 A;  3BB7 A;  1HUC B;  2DC9 A;  2F7D A;  1PPP A;  4MZS A;  4BOS A;  2R9N A;  4BOP A;  1BY8 A;  4BSQ A;  2PRE A;  1AU0 A;  2HWK A;  4X6J A;  2CB5 A;  3WXG A;  4BQV A;  3QSD A;  1BP4 A;  1CJL A;  2FRQ A;  4PP1 A;  3CBJ A;  3F5V A;  4QRX A;  4Q8G A;  6PAD A;  4WA6 A;  1CTE A;  2E03 A;  3HHI A;  2DZY A;  2AUX A;  3RVV A;  4BS6 A;  5E6J A;  2YJ2 A;  1BGO A;  2E02 A;  1ME3 A;  1S4V A;  3S3R A;  1PAD A;  3CH3 X;  3N4C A;  3PRM A;  3USV A;  2DC6 A;  2XU4 A;  2FRA A;  3IOQ A;  1PCI A;  3PNR A;  4AXM A;  3B21 A;  3BBA A;  5EZS A;  4YYV A;  1EWP A;  1VSN A;  4ZTB A;  1JQP A;  3WXF A;  1AYV A;  2JQF R;  1NPZ A;  4YYR A;  4D8E A;  3P5X A;  4KLB A;  2DZZ A;  3AI8 A;  4P6E A;  4RF1 A;  1AYU A;  4G54 A;  4BOZ A;  3D6S A;  1K3B B;  2R6N A;  1FH0 A;  3DF0 A;  4DMY A;  4QRG A;  2AVW A;  4CDE B;  1DKI A;  2FUD A;  4WUR A;  1KFU L;  3C0R A;  5CHV A;  4BPV A;  4PAD A;  1EF7 A;  2P7U A;  2J7Q A;  3H7D A;  2Y6E A;  3HHA A;  3OF8 A;  1MIR A;  2FYE A;  4D8I A;  1DF0 A;  5K16 A;  5CVO B;  2VHF A;  2FO5 A;  3PW3 A;  1AIM A;  3MHH A;  1KHQ A;  3OIS A;  1A6R A;  3K24 A;  3IUT A;  3I3T A;  2HXZ A;  1U9W A;  2DJG B;  2R9M A;  4BS5 A;  3E1Z B;  2JTC A;  4XZX A;  2PBH A;  3N3K A;  1Y4H A;  3PHU A;  1VJV A;  3C9E A;  1POP A;  1SNK A;  1Q6K A;  1CS8 A;  4YYU A;  2DC8 A;  2R9C A;  2XU1 A;  2B1N A;  1AU4 A;  2BU3 A;  1PPN A;  3KX1 A;  2PAD A;  9PAP A;  5J94 A;  1YT7 A;  1PPO A;  1KXR A;  1TL9 A;  2H7J A;  2ATO A;  3H8B A;  2DOS A;  4RF0 A;  3WXE A;  2YJ9 A;  1MDW A;  4P16 A;  3F75 A;  3TMP A;  3V6C A;  1NB5 A;  3O0U A;  1AEC A;  4QRV A;  3O1G A;  2JRI A;  1U9V A;  3OVX A;  1CQD A;  3OQC A;  1TLO A;  2NQG A;  2HH5 A;  3MP2 A;  4CDD B;  1PBH A;  4D8B A;  4PP2 E;  3BOW A;  2PNS A;  3P5W A;  2HD5 A;  1ATK A;  2OZ2 A;  2BTW B;  1BQI A;  4XR7 A;  3KWZ A;  1ZIV A;  4CDF B;  3PRP A;  2DCC A;  3IEJ A;  2UZJ A;  1YAL A;  3GCB A;  1ZCM A;  1DEU A;  4OEM A;  4FJC A;  4W5B A;  2R9O A;  4IUM A;  4QBB A;  1KHP A;  2DCA A;  1QXP A;  2ACT A;  3K8U A;  3I06 A;  2FE8 A;  2FTD A;  1SP4 B;  3ERV A;  4QH6 A;  1PXV A;  5KO3 A;  2AIM A;  1TU6 A;  3HD3 A;  3ZNH A;  3LFY A;  2AYN A;  2YJB A;  4N79 A;  2AS8 A;  3QJ3 A;  2JQG R;  4M0W A;  3W30 A;  4RY2 A;  1XKG A;  1QOL A;  1EWO A;  3O65 A;  3MTN A;  1QMY A;  1IWD A;  1CVZ A;  1U9X A;  1NL6 A;  4W4U A;  4OW0 A;  5A24 A;  4ZUX U;  2G8E A;  4R3D A;  1F2B A;  4BOQ A;  2F1G A;  1NB3 A;  2AU1 A;  2AUZ A;  4REZ A;  2C0Y A;  3PHX A;  3BCN A;  3TNX A;  3QT4 A;  2XU3 A;  3TRK A;  4HWY A;  1F2A A;  1YZB A;  4OEL A;  4RKX A;  4MM3 B;  4GUA A;  2G6D A;  3IFU A;  3IMA A;  3LXS A;  2BTW A;  4MI7 A;  3PSE A;  2Z84 A;  5F02 A;  4Q8H A;  4IP3 A;  3M99 A;  1ICF A;  4CDC B;  1ME4 A;  4K7C A;  4N8W A;  1MS6 A;  3PDF A;  2BDL A;  2DJF B;  5CVM A;  1YVB A;  2J7Q C;  4YYQ A;  2IPP B;  3MTV A;  3CH2 X;  3IV2 A;  1UKF A;  1PPD A;  2GFO A;  1PIP A;  4FIP A;  4X6H A;  2YJC A;  2XU5 A;  4AXL A;  3OF9 A;  3BC3 A;  1M6D A;  4PT5 A;  3H8C A;  1GCB A;  2BDZ A;  3KSE A;  4FK5 A;  2E00 A;  1X9Y A;  2O6X A;  1PE6 A;  2GHU A;  1CB5 A;  4OVZ B;  2OUL A;  2IBI A;  7PCK A;  3KFQ A;  4YYS A;  3BPM A;  3U8E A;  5EGW A;  5JZE A;  2ARY A;  2NQD B;  3BWK A;  4X6I A;  4YV8 A;  1CPJ A;  3PBH A;  1MEM A;  4BOU A;  4HXD B;  2DC7 A;  4XUI A;  8PCH A;  1YK7 A;  4CZW A;  3P5U A;  3RVX A;  3K9M A;  3PT2 A;  3RVW A;  4MZO A;  2B1M A;  1EWL A;  3B79 A;  1U9Q X;  3CBK A;  1CV8 A;  3MJ5 A;  4I07 A;  1F2C A;  3P5V A;  2YJ8 A;  2AYO A;  4P6G A;  3PHW A;  4I04 A;  1GEC E;  3IHP A;  3HWN A;  2P86 A;  3H89 A;  2P0R A;  3H6S A;  1QDQ A;  1O0E A;  5JH3 A;  4I05 A;  1AU3 A;  1KFX L;  3BPF A;  4DMX A;  1U5I A;  1NLJ A;  1EWM A;  5EF4 A;  4YYW A;  4MSX A;  4W5C A;  2NQI A;  1MEG A;  2FT2 A;  5JA7 A;  4N4Z A;  4RNA A;  1NQC A;  4PI3 A;  3N3G A;  3W31 A;  1ITO A;  2FQ9 A;  3MOR A;  3RNV A;  1GLO A;  2DCD A;  2AGA A;  3E9S A;  1F29 A;  2HHN A;  4A5U A;  2CIO A;  3KWB X;  1GMY A;  2NQA A;  1Y08 A;  2G7Y A;  3BY4 A;  1AYW A;  5PAD A;  3KKU A;  4YVA A;  3MHS A;  2G8J A;  2E01 A;  3KW9 A;  2Y5B A;  3V6E A;  1THE A;  3NHE A; 
#chains in the Genus database with same CATH homology
 4OVZ A;  2FE8 A;  4PT5 A;  5EZQ A;  1PVJ A;  2J7Q A;  4D8I A;  5KO3 A;  3ZNH A;  4OVZ B;  3BB7 A;  4M0W A;  5JZE A;  3W30 A;  4BOS A;  4BOP A;  2JTC A;  4XZX A;  2HWK A;  4BOU A;  3O65 A;  3PHU A;  4HXD B;  3PT2 A;  3MJ5 A;  2BU3 A;  3PHW A;  4OW0 A;  5E6J A;  4R3D A;  4BOQ A;  2DOS A;  4RF0 A;  4REZ A;  4P16 A;  3PHX A;  3TMP A;  3TRK A;  3PRM A;  2JRI A;  1YZB A;  4RKX A;  4MM3 B;  3B21 A;  3OQC A;  4GUA A;  3BBA A;  3IFU A;  5EZS A;  2BTW A;  4ZTB A;  4MI7 A;  4RNA A;  3PSE A;  2Z84 A;  3MP2 A;  4D8B A;  3W31 A;  4IP3 A;  3RNV A;  4D8E A;  2AGA A;  3E9S A;  4A5U A;  2BTW B;  4RF1 A;  2J7Q C;  3PRP A;  3BY4 A;  3MTV A;  4BOZ A;  2UZJ A;  1UKF A;  1DKI A;  4IUM A;  4WUR A;  3C0R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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