4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
molecule keywords Streptopain
molecule tags Hydrolase/hydrolase inhibitor
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
3BB7A 4D8IA 2UZJA 3BBAA 1PVJA 1DKIA 2JTCA 4D8EA 4RKXA 4D8BA
chains in the Genus database with same CATH superfamily
2DZZA 3N3KA 9PAPA 1AU2A 2G8JA 1KXRA 2CIOA 1NB3A 1PBHA 3F5VA 2NQGA 5EZQA 4YV8A 2FRQA 2R9FA 3PHWA 2JQFR 4IP3A 4G54A 2OP3A 4BS6A 1UKFA 2YJCA 4OEMA 4CDCB 4BS5A 2DCDA 3K8UA 4YYWA 1MHWA 3RVWA 2HH5A 2F1GA 2HHNA 1K3BB 1TLOA 3PBHA 4BQVA 1MDWA 1GLOA 1BP4A 2GFOA 1CPJA 1QMYA 4IUMA 3KSEA 1O0EA 3IHPA 4OW0A 4MSXA 3MHHA 4QRXA 1YALA 2YJ2A 2DCAA 2R6NA 1BGOA 1KHQA 2IBIA 5CVNB 1MEMA 5K16A 3PW3A 3OQCA 5EZSA 3CBKA 3BPMA 2BDZA 4CDEB 2FYEA 4Q8HA 4PP1A 4D8BA 2DC7A 1DEUA 2DJFB 3RVXA 3H7DA 3IFUA 3D6SA 4N4ZA 4XUIA 2ARYA 1Y4HA 2G7YA 1CVZA 1U9WA 2FTDA 1PPNA 3H8BA 5E6JA 1POPA 5F02A 2PBHA 4HWYA 1PVJA 1CJLA 2AVWA 1ME4A 2AUZA 5JZEA 3OVZA 2O6XA 2FRAA 2YJ8A 3N3GA 3BOWA 1F2CA 3IMAA 2Y6EA 3K9MA 2FT2A 4P6EA 1ME3A 1F29A 2WBFX 3KFQA 3MP2A 5CHVA 1PE6A 1S4VA 3HD3A 5FPWA 1EF7A 2DCBA 4KLBA 4D8IA 1ICFA 2ATOA 4RNAA 4QH6A 3KKUA 1KFUL 5CVMA 2FUDA 4QRGA 1PPPA 4FIPA 1PPOA 3MORA 1PPDA 1QDQA 1KHPA 4X6HA 1F2AA 2B1MA 2ACTA 1CSBB 2H7JA 2R9OA 2F7DA 4W5BA 2AUXA 1CS8A 1VJVA 4YYQA 2DJGB 1YK8A 3CBJA 4MM3B 1AYVA 2YJBA 3ERVA 3RVVA 1M6DA 1NQCA 2DZYA 1AU4A 1U9QX 3H8CA 4AXLA 2R9NA 3HHAA 2XU3A 1BQIA 3CH3X 4MZSA 2HXZA 3S3QA 4XZXA 3MHSA 1YZBA 1TU6A 2E00A 4P16A 3W31A 3WXFA 5J94A 3B79A 3IUTA 4I07A 4N8WA 2E01A 3E1ZB 5CVOB 1EWOA 1PADA 2R9CA 2BU3A 1Q6KA 2C0YA 3C9EA 1AU0A 4ZTBA 4DMXA 4OVZB 2JQGR 4M0WA 4REZA 3KWBX 2VHFA 7PCKA 1EWLA 1XKGA 2P7UA 3IV2A 4YYVA 1AECA 3BB7A 3P5XA 5JA7A 3H89A 5EGWA 4GUAA 3K24A 2IPPB 3W30A 4BOQA 4K7CA 2AIMA 2AYNA 1GECE 2XU1A 3NHEA 1BY8A 2DC8A 3QJ3A 2J7QA 2OZ2A 4X6IA 1U5IA 3O1GA 1TL9A 3QSDA 4QBBA 2E03A 1MEGA 4OVZA 4N79A 3OISA 3AI8A 4BSQA 1PCIA 3IOQA 1GCBA 3V6CA 3PHUA 4BOSA 1CQDA 3B21A 2AU1A 1DF0A 1THEA 3RNVA 3CH2X 4RY2A 3IEJA 8PCHA 3PT2A 1QOLA 3BPFA 3MTVA 3PRMA 4BOZA 3F75A 1U9VA 2HD5A 1NB5A 1VSNA 4P6GA 2PREA 2FE8A 4QRVA 1MS6A 2HWKA 1F2BA 3WXGA 1IWDA 1CB5A 1EWMA 3O0UA 4W4UA 3U8EA 3OVXA 3M99A 1AYUA 3ZNHA 1YT7A 3I06A 2AYOA 1U9XA 2DC6A 2OULA 3PRPA 3S3RA 1AU3A 1FH0A 4YYRA 4WURA 4Q8GA 1AYWA 3BWKA 3P5VA 3KW9A 4W5CA 3PDFA 2UZJA 3OF8A 4YVAA 2Y5BA 3PNRA 1ITOA 2VHSA 3HWNA 1AIMA 2FQ9A 3H6SA 2NQIA 1X9YA 1MIRA 3MTNA 4WA6A 4D8EA 1PXVA 3V6EA 4CZWA 2CB5A 3N4CA 3QT4A 2JTCA 4MI7A 4XR7A 4HXDB 3LFYA 1SNKA 3ZUAA 3C0RA 4FK5A 1CV8A 2DOSA 1QXPA 3USVA 4PI3A 2G8EA 4BPVA 1PIPA 3BCNA 4YYSA 3DF0A 4RKXA 3HHIA 4FJCA 2DCCA 4BOUA 2P86A 3TRKA 2XU4A 3BY4A 3MJ5A 4OELA 4YYUA 4ZUXU 3E9SA 5PADA 2J7QC 4PP2E 2BTWB 1YK7A 4PADA 2GHUA 1NLJA 2AGAA 2PNSA 2R9MA 4MZOA 1STFE 4DMYA 1NPZA 2FO5A 1NL6A 3WXEA 1EWPA 5KO3A 3OF9A 1DKIA 2NQDB 4I05A 3O65A 2Z84A 2JRIA 5EF4A 3GCBA 3PSEA 4RF0A 3PHXA 3LXSA 2BTWA 3BBAA 2PADA 2P0RA 5A24A 4CDDB 1SP4B 1GMYA 6PADA 5JH3A 4R3DA 2E02A 3I3TA 4CDFB 4PT5A 4RF1A 1A6RA 1YVBA 3TMPA 2XU5A 1CTEA 3BC3A 3P5WA 4AXMA 4A5UA 1KFXL 1Y08A 1ZCMA 2YJ9A 4X6JA 3TNXA 2NQAA 5CHTA 4BOPA 2AS8A 2B1NA 3KX1A 1ZIVA 4I04A 1HUCB 1JQPA 2BDLA 1ATKA 2DC9A 3KWZA 3P5UA 2G6DA
chains in the Genus database with same CATH topology
3MP2A 3C0RA 2DOSA 3BB7A 4D8IA 5EZQA 4RNAA 4GUAA 3PHWA 3W30A 4RKXA 4BOQA 4IP3A 4BOUA 3TRKA 1UKFA 3BY4A 2J7QA 3MJ5A 3E9SA 4OVZA 2J7QC 2BTWB 3PHUA 4BOSA 3B21A 2AGAA 3RNVA 3PT2A 3MTVA 3PRMA 4BOZA 4IUMA 4OW0A 4MM3B 2FE8A 2HWKA 5KO3A 1DKIA 3O65A 2Z84A 2JRIA 3PSEA 4RF0A 3PHXA 2BTWA 3BBAA 3OQCA 3ZNHA 5EZSA 3PRPA 4WURA 4XZXA 4R3DA 1YZBA 4P16A 3W31A 4PT5A 4D8BA 4RF1A 2UZJA 3TMPA 3IFUA 4A5UA 2BU3A 5E6JA 1PVJA 4D8EA 4BOPA 5JZEA 4ZTBA 4OVZB 4M0WA 2JTCA 4REZA 4MI7A 4HXDB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BB7 A;  4D8I A;  2UZJ A;  3BBA A;  1PVJ A;  1DKI A;  2JTC A;  4D8E A;  4RKX A;  4D8B A; 
#chains in the Genus database with same CATH topology
 2DZZ A;  3N3K A;  9PAP A;  1AU2 A;  2G8J A;  1KXR A;  2CIO A;  1NB3 A;  1PBH A;  3F5V A;  2NQG A;  5EZQ A;  4YV8 A;  2FRQ A;  2R9F A;  3PHW A;  2JQF R;  4IP3 A;  4G54 A;  2OP3 A;  4BS6 A;  1UKF A;  2YJC A;  4OEM A;  4CDC B;  4BS5 A;  2DCD A;  3K8U A;  4YYW A;  1MHW A;  3RVW A;  2HH5 A;  2F1G A;  2HHN A;  1K3B B;  1TLO A;  3PBH A;  4BQV A;  1MDW A;  1GLO A;  1BP4 A;  2GFO A;  1CPJ A;  1QMY A;  4IUM A;  3KSE A;  1O0E A;  3IHP A;  4OW0 A;  4MSX A;  3MHH A;  4QRX A;  1YAL A;  2YJ2 A;  2DCA A;  2R6N A;  1BGO A;  1KHQ A;  2IBI A;  5CVN B;  1MEM A;  5K16 A;  3PW3 A;  3OQC A;  5EZS A;  3CBK A;  3BPM A;  2BDZ A;  4CDE B;  2FYE A;  4Q8H A;  4PP1 A;  4D8B A;  2DC7 A;  1DEU A;  2DJF B;  3RVX A;  3H7D A;  3IFU A;  3D6S A;  4N4Z A;  4XUI A;  2ARY A;  1Y4H A;  2G7Y A;  1CVZ A;  1U9W A;  2FTD A;  1PPN A;  3H8B A;  5E6J A;  1POP A;  5F02 A;  2PBH A;  4HWY A;  1PVJ A;  1CJL A;  2AVW A;  1ME4 A;  2AUZ A;  5JZE A;  3OVZ A;  2O6X A;  2FRA A;  2YJ8 A;  3N3G A;  3BOW A;  1F2C A;  3IMA A;  2Y6E A;  3K9M A;  2FT2 A;  4P6E A;  1ME3 A;  1F29 A;  2WBF X;  3KFQ A;  3MP2 A;  5CHV A;  1PE6 A;  1S4V A;  3HD3 A;  5FPW A;  1EF7 A;  2DCB A;  4KLB A;  4D8I A;  1ICF A;  2ATO A;  4RNA A;  4QH6 A;  3KKU A;  1KFU L;  5CVM A;  2FUD A;  4QRG A;  1PPP A;  4FIP A;  1PPO A;  3MOR A;  1PPD A;  1QDQ A;  1KHP A;  4X6H A;  1F2A A;  2B1M A;  2ACT A;  1CSB B;  2H7J A;  2R9O A;  2F7D A;  4W5B A;  2AUX A;  1CS8 A;  1VJV A;  4YYQ A;  2DJG B;  1YK8 A;  3CBJ A;  4MM3 B;  1AYV A;  2YJB A;  3ERV A;  3RVV A;  1M6D A;  1NQC A;  2DZY A;  1AU4 A;  1U9Q X;  3H8C A;  4AXL A;  2R9N A;  3HHA A;  2XU3 A;  1BQI A;  3CH3 X;  4MZS A;  2HXZ A;  3S3Q A;  4XZX A;  3MHS A;  1YZB A;  1TU6 A;  2E00 A;  4P16 A;  3W31 A;  3WXF A;  5J94 A;  3B79 A;  3IUT A;  4I07 A;  4N8W A;  2E01 A;  3E1Z B;  5CVO B;  1EWO A;  1PAD A;  2R9C A;  2BU3 A;  1Q6K A;  2C0Y A;  3C9E A;  1AU0 A;  4ZTB A;  4DMX A;  4OVZ B;  2JQG R;  4M0W A;  4REZ A;  3KWB X;  2VHF A;  7PCK A;  1EWL A;  1XKG A;  2P7U A;  3IV2 A;  4YYV A;  1AEC A;  3BB7 A;  3P5X A;  5JA7 A;  3H89 A;  5EGW A;  4GUA A;  3K24 A;  2IPP B;  3W30 A;  4BOQ A;  4K7C A;  2AIM A;  2AYN A;  1GEC E;  2XU1 A;  3NHE A;  1BY8 A;  2DC8 A;  3QJ3 A;  2J7Q A;  2OZ2 A;  4X6I A;  1U5I A;  3O1G A;  1TL9 A;  3QSD A;  4QBB A;  2E03 A;  1MEG A;  4OVZ A;  4N79 A;  3OIS A;  3AI8 A;  4BSQ A;  1PCI A;  3IOQ A;  1GCB A;  3V6C A;  3PHU A;  4BOS A;  1CQD A;  3B21 A;  2AU1 A;  1DF0 A;  1THE A;  3RNV A;  3CH2 X;  4RY2 A;  3IEJ A;  8PCH A;  3PT2 A;  1QOL A;  3BPF A;  3MTV A;  3PRM A;  4BOZ A;  3F75 A;  1U9V A;  2HD5 A;  1NB5 A;  1VSN A;  4P6G A;  2PRE A;  2FE8 A;  4QRV A;  1MS6 A;  2HWK A;  1F2B A;  3WXG A;  1IWD A;  1CB5 A;  1EWM A;  3O0U A;  4W4U A;  3U8E A;  3OVX A;  3M99 A;  1AYU A;  3ZNH A;  1YT7 A;  3I06 A;  2AYO A;  1U9X A;  2DC6 A;  2OUL A;  3PRP A;  3S3R A;  1AU3 A;  1FH0 A;  4YYR A;  4WUR A;  4Q8G A;  1AYW A;  3BWK A;  3P5V A;  3KW9 A;  4W5C A;  3PDF A;  2UZJ A;  3OF8 A;  4YVA A;  2Y5B A;  3PNR A;  1ITO A;  2VHS A;  3HWN A;  1AIM A;  2FQ9 A;  3H6S A;  2NQI A;  1X9Y A;  1MIR A;  3MTN A;  4WA6 A;  4D8E A;  1PXV A;  3V6E A;  4CZW A;  2CB5 A;  3N4C A;  3QT4 A;  2JTC A;  4MI7 A;  4XR7 A;  4HXD B;  3LFY A;  1SNK A;  3ZUA A;  3C0R A;  4FK5 A;  1CV8 A;  2DOS A;  1QXP A;  3USV A;  4PI3 A;  2G8E A;  4BPV A;  1PIP A;  3BCN A;  4YYS A;  3DF0 A;  4RKX A;  3HHI A;  4FJC A;  2DCC A;  4BOU A;  2P86 A;  3TRK A;  2XU4 A;  3BY4 A;  3MJ5 A;  4OEL A;  4YYU A;  4ZUX U;  3E9S A;  5PAD A;  2J7Q C;  4PP2 E;  2BTW B;  1YK7 A;  4PAD A;  2GHU A;  1NLJ A;  2AGA A;  2PNS A;  2R9M A;  4MZO A;  1STF E;  4DMY A;  1NPZ A;  2FO5 A;  1NL6 A;  3WXE A;  1EWP A;  5KO3 A;  3OF9 A;  1DKI A;  2NQD B;  4I05 A;  3O65 A;  2Z84 A;  2JRI A;  5EF4 A;  3GCB A;  3PSE A;  4RF0 A;  3PHX A;  3LXS A;  2BTW A;  3BBA A;  2PAD A;  2P0R A;  5A24 A;  4CDD B;  1SP4 B;  1GMY A;  6PAD A;  5JH3 A;  4R3D A;  2E02 A;  3I3T A;  4CDF B;  4PT5 A;  4RF1 A;  1A6R A;  1YVB A;  3TMP A;  2XU5 A;  1CTE A;  3BC3 A;  3P5W A;  4AXM A;  4A5U A;  1KFX L;  1Y08 A;  1ZCM A;  2YJ9 A;  4X6J A;  3TNX A;  2NQA A;  5CHT A;  4BOP A;  2AS8 A;  2B1N A;  3KX1 A;  1ZIV A;  4I04 A;  1HUC B;  1JQP A;  2BDL A;  1ATK A;  2DC9 A;  3KWZ A;  3P5U A;  2G6D A; 
#chains in the Genus database with same CATH homology
 3MP2 A;  3C0R A;  2DOS A;  3BB7 A;  4D8I A;  5EZQ A;  4RNA A;  4GUA A;  3PHW A;  3W30 A;  4RKX A;  4BOQ A;  4IP3 A;  4BOU A;  3TRK A;  1UKF A;  3BY4 A;  2J7Q A;  3MJ5 A;  3E9S A;  4OVZ A;  2J7Q C;  2BTW B;  3PHU A;  4BOS A;  3B21 A;  2AGA A;  3RNV A;  3PT2 A;  3MTV A;  3PRM A;  4BOZ A;  4IUM A;  4OW0 A;  4MM3 B;  2FE8 A;  2HWK A;  5KO3 A;  1DKI A;  3O65 A;  2Z84 A;  2JRI A;  3PSE A;  4RF0 A;  3PHX A;  2BTW A;  3BBA A;  3OQC A;  3ZNH A;  5EZS A;  3PRP A;  4WUR A;  4XZX A;  4R3D A;  1YZB A;  4P16 A;  3W31 A;  4PT5 A;  4D8B A;  4RF1 A;  2UZJ A;  3TMP A;  3IFU A;  4A5U A;  2BU3 A;  5E6J A;  1PVJ A;  4D8E A;  4BOP A;  5JZE A;  4ZTB A;  4OVZ B;  4M0W A;  2JTC A;  4REZ A;  4MI7 A;  4HXD B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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