4D8BA

High resolution structure of monomeric s. progenies speb reveals role of glycine-rich active site loop
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
molecule tags Hydrolase
source organism Streptococcus pyogenes
molecule keywords Streptopain
total genus 75
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8bA00
4D8BA 4D8EA 3BB7A 1PVJA 2JTCA 3BBAA 4RKXA 4D8IA 2UZJA 1DKIA
chains in the Genus database with same CATH superfamily
1PPPA 3AI8A 3C9EA 3H6SA 1SNKA 2AUXA 3U8EA 3LXSA 4BPVA 4Q8GA 2G8EA 3V6EA 3MORA 3S3RA 1STFE 1PPDA 1POPA 2XU1A 3F75A 4BQVA 1F2BA 2R9FA 1F2AA 5JZEA 2XU4A 2AIMA 4XR7A 1MS6A 1S4VA 5A24A 1EWLA 2FO5A 4M0WA 2OULA 1F29A 1NPZA 3E9SA 1K3BB 4I04A 3BPMA 1CJLA 3PRPA 1EF7A 2ACTA 1CPJA 3PHUA 3CBJA 4FK5A 2DZYA 3IHPA 3BB7A 2IPPB 4XZXA 2FRAA 4PP1A 4BOSA 3MP2A 1EWOA 4G54A 4QRXA 5CVMA 2GHUA 4HWYA 3IUTA 3K24A 4X6JA 1PXVA 3V6CA 2HH5A 4YYWA 4QH6A 1EWMA 1KHQA 1U5IA 4REZA 2E02A 3H8CA 4YYRA 3PBHA 1AECA 2BU3A 2R9MA 3OF9A 4MZOA 4X6IA 1DF0A 3TRKA 4IUMA 1PPOA 3OISA 4RNAA 2J7QC 1TLOA 3RVWA 2H7JA 1PIPA 1YALA 3CH3X 3MJ5A 4BS5A 3OQCA 4P16A 3RVXA 4PT5A 1UKFA 3IOQA 4AXMA 5CVNB 1NLJA 2C0YA 4A5UA 1DEUA 1VSNA 2XU3A 2OZ2A 2ATOA 4RY2A 4QRGA 5K16A 3M99A 4MM3B 1AYVA 4CZWA 2JQGR 3PRMA 1MEMA 1KHPA 3HWNA 4KLBA 3IV2A 4YYVA 2BTWA 2R6NA 2FTDA 3RNVA 2CIOA 4MZSA 3IMAA 3PSEA 1CTEA 2J7QA 1KXRA 2P7UA 3BOWA 8PCHA 1AIMA 1Q6KA 2FUDA 4P6GA 3RVVA 5EF4A 3BWKA 3QT4A 2YJ2A 2UZJA 2PBHA 2E03A 4DMYA 5EZSA 2DC8A 2B1NA 2G8JA 5JA7A 3F5VA 1YT7A 3BC3A 2FYEA 9PAPA 1PBHA 5EZQA 1GMYA 4QRVA 4IP3A 3IEJA 2FE8A 2AUZA 1CB5A 1NQCA 4RKXA 3N3GA 3MTNA 2YJ9A 4WURA 2DOSA 4PP2E 2AU1A 2ARYA 3TMPA 2PREA 3KX1A 4ZUXU 1CVZA 4XUIA 3WXGA 4YYUA 3PT2A 1YK7A 4W5BA 1U9QX 4R3DA 1AU0A 5E6JA 2DJGB 4OVZB 1GCBA 2YJBA 5CHVA 3DF0A 3BCNA 3CH2X 1QOLA 1PADA 1AU4A 1X9YA 4PI3A 6PADA 2HHNA 3KWBX 1SP4B 2OP3A 1BP4A 3O0UA 2JQFR 2WBFX 3IFUA 3N3KA 4D8EA 2DC7A 3D6SA 1ITOA 1NL6A 1JQPA 3H8BA 3S3QA 3KW9A 3CBKA 3PHWA 4FJCA 3KSEA 1TL9A 1F2CA 1MHWA 3P5WA 4MSXA 3C0RA 4D8BA 2FQ9A 2NQIA 1BGOA 1BY8A 2AVWA 3WXEA 1GLOA 4AXLA 4BOQA 1Y4HA 3ERVA 1YZBA 1AU3A 4D8IA 2AGAA 3PNRA 4N4ZA 1PE6A 5J94A 3QSDA 4BS6A 1CV8A 1GECE 5JH3A 2AS8A 3B21A 4BSQA 4YVAA 2G7YA 2XU5A 1U9XA 2AYNA 4W4UA 1YVBA 2JRIA 4ZTBA 3KKUA 3BPFA 1NB5A 3P5UA 7PCKA 4CDDB 1QMYA 2IBIA 3OF8A 3K9MA 1BQIA 2E00A 1PVJA 3NHEA 5CVOB 4RF0A 5EGWA 3OVZA 2HXZA 4HXDB 2AYOA 1MIRA 3H89A 2DCAA 2R9OA 2VHFA 3E1ZB 3TNXA 2Y6EA 4YYSA 4YV8A 1XKGA 1YK8A 2CB5A 1FH0A 4N8WA 3KFQA 1ME4A 3B79A 1VJVA 3KWZA 3I06A 1M6DA 1MDWA 2NQAA 4BOUA 2R9NA 3MHSA 2BDZA 4N79A 1AYUA 4BOZA 2F7DA 2HWKA 2R9CA 1TU6A 4W5CA 4BOPA 1DKIA 4OELA 4FIPA 2YJ8A 4P6EA 3WXFA 1CSBB 1PPNA 5PADA 2E01A 2BDLA 3K8UA 1KFUL 1IWDA 2P0RA 2NQGA 4QBBA 3O1GA 3P5VA 1ZIVA 1ME3A 3O65A 1ATKA 2HD5A 4WA6A 1HUCB 1ICFA 2PNSA 4I05A 3I3TA 2DZZA 3LFYA 1EWPA 3PHXA 3QJ3A 3ZNHA 3GCBA 4Q8HA 4PADA 3PDFA 3BY4A 3OVXA 2FT2A 1AYWA 3ZUAA 2G6DA 2NQDB 2Y5BA 4OVZA 2FRQA 2YJCA 5FPWA 5CHTA 1MEGA 1CS8A 2DCBA 4CDCB 3MHHA 3HHIA 1QXPA 2DC6A 2VHSA 2BTWB 2P86A 3P5XA 5KO3A 4X6HA 2Z84A 1THEA 2GFOA 4MI7A 2F1GA 1NB3A 3W30A 1KFXL 1U9VA 4OW0A 3H7DA 1PCIA 1QDQA 2B1MA 4GUAA 4K7CA 1U9WA 1ZCMA 1O0EA 3N4CA 2DC9A 1Y08A 5F02A 2O6XA 2JTCA 1CQDA 4I07A 4CDEB 3HHAA 2DCDA 4DMXA 1A6RA 3W31A 3HD3A 3BBAA 4RF1A 2PADA 4OEMA 3PW3A 2DCCA 3MTVA 4CDFB 3USVA 1AU2A 4YYQA 2DJFB
chains in the Genus database with same CATH topology
4A5UA 2HWKA 4BOPA 1DKIA 4MM3B 3PRMA 3IFUA 4D8EA 2BTWA 5JZEA 3RNVA 3PHWA 3PSEA 4M0WA 3O65A 2J7QA 3E9SA 4D8BA 3C0RA 3PRPA 3PHXA 3ZNHA 4BOQA 1YZBA 3PHUA 4D8IA 2UZJA 2AGAA 3BY4A 3BB7A 4XZXA 5EZSA 4BOSA 3MP2A 4OVZA 3B21A 2JRIA 4ZTBA 5EZQA 4IP3A 2BTWB 5KO3A 2FE8A 2Z84A 4MI7A 4REZA 3W30A 1PVJA 4RF0A 4OW0A 4RKXA 4HXDB 2BU3A 4GUAA 4WURA 2DOSA 3TMPA 3TRKA 4IUMA 2JTCA 4RNAA 2J7QC 3W31A 3BBAA 3PT2A 3MJ5A 3OQCA 4P16A 4PT5A 4RF1A 4R3DA 5E6JA 3MTVA 4OVZB 1UKFA 4BOUA 4BOZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8B A;  4D8E A;  3BB7 A;  1PVJ A;  2JTC A;  3BBA A;  4RKX A;  4D8I A;  2UZJ A;  1DKI A; 
#chains in the Genus database with same CATH topology
 1PPP A;  3AI8 A;  3C9E A;  3H6S A;  1SNK A;  2AUX A;  3U8E A;  3LXS A;  4BPV A;  4Q8G A;  2G8E A;  3V6E A;  3MOR A;  3S3R A;  1STF E;  1PPD A;  1POP A;  2XU1 A;  3F75 A;  4BQV A;  1F2B A;  2R9F A;  1F2A A;  5JZE A;  2XU4 A;  2AIM A;  4XR7 A;  1MS6 A;  1S4V A;  5A24 A;  1EWL A;  2FO5 A;  4M0W A;  2OUL A;  1F29 A;  1NPZ A;  3E9S A;  1K3B B;  4I04 A;  3BPM A;  1CJL A;  3PRP A;  1EF7 A;  2ACT A;  1CPJ A;  3PHU A;  3CBJ A;  4FK5 A;  2DZY A;  3IHP A;  3BB7 A;  2IPP B;  4XZX A;  2FRA A;  4PP1 A;  4BOS A;  3MP2 A;  1EWO A;  4G54 A;  4QRX A;  5CVM A;  2GHU A;  4HWY A;  3IUT A;  3K24 A;  4X6J A;  1PXV A;  3V6C A;  2HH5 A;  4YYW A;  4QH6 A;  1EWM A;  1KHQ A;  1U5I A;  4REZ A;  2E02 A;  3H8C A;  4YYR A;  3PBH A;  1AEC A;  2BU3 A;  2R9M A;  3OF9 A;  4MZO A;  4X6I A;  1DF0 A;  3TRK A;  4IUM A;  1PPO A;  3OIS A;  4RNA A;  2J7Q C;  1TLO A;  3RVW A;  2H7J A;  1PIP A;  1YAL A;  3CH3 X;  3MJ5 A;  4BS5 A;  3OQC A;  4P16 A;  3RVX A;  4PT5 A;  1UKF A;  3IOQ A;  4AXM A;  5CVN B;  1NLJ A;  2C0Y A;  4A5U A;  1DEU A;  1VSN A;  2XU3 A;  2OZ2 A;  2ATO A;  4RY2 A;  4QRG A;  5K16 A;  3M99 A;  4MM3 B;  1AYV A;  4CZW A;  2JQG R;  3PRM A;  1MEM A;  1KHP A;  3HWN A;  4KLB A;  3IV2 A;  4YYV A;  2BTW A;  2R6N A;  2FTD A;  3RNV A;  2CIO A;  4MZS A;  3IMA A;  3PSE A;  1CTE A;  2J7Q A;  1KXR A;  2P7U A;  3BOW A;  8PCH A;  1AIM A;  1Q6K A;  2FUD A;  4P6G A;  3RVV A;  5EF4 A;  3BWK A;  3QT4 A;  2YJ2 A;  2UZJ A;  2PBH A;  2E03 A;  4DMY A;  5EZS A;  2DC8 A;  2B1N A;  2G8J A;  5JA7 A;  3F5V A;  1YT7 A;  3BC3 A;  2FYE A;  9PAP A;  1PBH A;  5EZQ A;  1GMY A;  4QRV A;  4IP3 A;  3IEJ A;  2FE8 A;  2AUZ A;  1CB5 A;  1NQC A;  4RKX A;  3N3G A;  3MTN A;  2YJ9 A;  4WUR A;  2DOS A;  4PP2 E;  2AU1 A;  2ARY A;  3TMP A;  2PRE A;  3KX1 A;  4ZUX U;  1CVZ A;  4XUI A;  3WXG A;  4YYU A;  3PT2 A;  1YK7 A;  4W5B A;  1U9Q X;  4R3D A;  1AU0 A;  5E6J A;  2DJG B;  4OVZ B;  1GCB A;  2YJB A;  5CHV A;  3DF0 A;  3BCN A;  3CH2 X;  1QOL A;  1PAD A;  1AU4 A;  1X9Y A;  4PI3 A;  6PAD A;  2HHN A;  3KWB X;  1SP4 B;  2OP3 A;  1BP4 A;  3O0U A;  2JQF R;  2WBF X;  3IFU A;  3N3K A;  4D8E A;  2DC7 A;  3D6S A;  1ITO A;  1NL6 A;  1JQP A;  3H8B A;  3S3Q A;  3KW9 A;  3CBK A;  3PHW A;  4FJC A;  3KSE A;  1TL9 A;  1F2C A;  1MHW A;  3P5W A;  4MSX A;  3C0R A;  4D8B A;  2FQ9 A;  2NQI A;  1BGO A;  1BY8 A;  2AVW A;  3WXE A;  1GLO A;  4AXL A;  4BOQ A;  1Y4H A;  3ERV A;  1YZB A;  1AU3 A;  4D8I A;  2AGA A;  3PNR A;  4N4Z A;  1PE6 A;  5J94 A;  3QSD A;  4BS6 A;  1CV8 A;  1GEC E;  5JH3 A;  2AS8 A;  3B21 A;  4BSQ A;  4YVA A;  2G7Y A;  2XU5 A;  1U9X A;  2AYN A;  4W4U A;  1YVB A;  2JRI A;  4ZTB A;  3KKU A;  3BPF A;  1NB5 A;  3P5U A;  7PCK A;  4CDD B;  1QMY A;  2IBI A;  3OF8 A;  3K9M A;  1BQI A;  2E00 A;  1PVJ A;  3NHE A;  5CVO B;  4RF0 A;  5EGW A;  3OVZ A;  2HXZ A;  4HXD B;  2AYO A;  1MIR A;  3H89 A;  2DCA A;  2R9O A;  2VHF A;  3E1Z B;  3TNX A;  2Y6E A;  4YYS A;  4YV8 A;  1XKG A;  1YK8 A;  2CB5 A;  1FH0 A;  4N8W A;  3KFQ A;  1ME4 A;  3B79 A;  1VJV A;  3KWZ A;  3I06 A;  1M6D A;  1MDW A;  2NQA A;  4BOU A;  2R9N A;  3MHS A;  2BDZ A;  4N79 A;  1AYU A;  4BOZ A;  2F7D A;  2HWK A;  2R9C A;  1TU6 A;  4W5C A;  4BOP A;  1DKI A;  4OEL A;  4FIP A;  2YJ8 A;  4P6E A;  3WXF A;  1CSB B;  1PPN A;  5PAD A;  2E01 A;  2BDL A;  3K8U A;  1KFU L;  1IWD A;  2P0R A;  2NQG A;  4QBB A;  3O1G A;  3P5V A;  1ZIV A;  1ME3 A;  3O65 A;  1ATK A;  2HD5 A;  4WA6 A;  1HUC B;  1ICF A;  2PNS A;  4I05 A;  3I3T A;  2DZZ A;  3LFY A;  1EWP A;  3PHX A;  3QJ3 A;  3ZNH A;  3GCB A;  4Q8H A;  4PAD A;  3PDF A;  3BY4 A;  3OVX A;  2FT2 A;  1AYW A;  3ZUA A;  2G6D A;  2NQD B;  2Y5B A;  4OVZ A;  2FRQ A;  2YJC A;  5FPW A;  5CHT A;  1MEG A;  1CS8 A;  2DCB A;  4CDC B;  3MHH A;  3HHI A;  1QXP A;  2DC6 A;  2VHS A;  2BTW B;  2P86 A;  3P5X A;  5KO3 A;  4X6H A;  2Z84 A;  1THE A;  2GFO A;  4MI7 A;  2F1G A;  1NB3 A;  3W30 A;  1KFX L;  1U9V A;  4OW0 A;  3H7D A;  1PCI A;  1QDQ A;  2B1M A;  4GUA A;  4K7C A;  1U9W A;  1ZCM A;  1O0E A;  3N4C A;  2DC9 A;  1Y08 A;  5F02 A;  2O6X A;  2JTC A;  1CQD A;  4I07 A;  4CDE B;  3HHA A;  2DCD A;  4DMX A;  1A6R A;  3W31 A;  3HD3 A;  3BBA A;  4RF1 A;  2PAD A;  4OEM A;  3PW3 A;  2DCC A;  3MTV A;  4CDF B;  3USV A;  1AU2 A;  4YYQ A;  2DJF B; 
#chains in the Genus database with same CATH homology
 4A5U A;  2HWK A;  4BOP A;  1DKI A;  4MM3 B;  3PRM A;  3IFU A;  4D8E A;  2BTW A;  5JZE A;  3RNV A;  3PHW A;  3PSE A;  4M0W A;  3O65 A;  2J7Q A;  3E9S A;  4D8B A;  3C0R A;  3PRP A;  3PHX A;  3ZNH A;  4BOQ A;  1YZB A;  3PHU A;  4D8I A;  2UZJ A;  2AGA A;  3BY4 A;  3BB7 A;  4XZX A;  5EZS A;  4BOS A;  3MP2 A;  4OVZ A;  3B21 A;  2JRI A;  4ZTB A;  5EZQ A;  4IP3 A;  2BTW B;  5KO3 A;  2FE8 A;  2Z84 A;  4MI7 A;  4REZ A;  3W30 A;  1PVJ A;  4RF0 A;  4OW0 A;  4RKX A;  4HXD B;  2BU3 A;  4GUA A;  4WUR A;  2DOS A;  3TMP A;  3TRK A;  4IUM A;  2JTC A;  4RNA A;  2J7Q C;  3W31 A;  3BBA A;  3PT2 A;  3MJ5 A;  3OQC A;  4P16 A;  4PT5 A;  4RF1 A;  4R3D A;  5E6J A;  3MTV A;  4OVZ B;  1UKF A;  4BOU A;  4BOZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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