4D8EA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
molecule tags Hydrolase
source organism Streptococcus pyogenes
molecule keywords Streptopain
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8eA00
4D8EA 2UZJA 3BBAA 4D8BA 4D8IA 1PVJA 3BB7A 4RKXA 1DKIA 2JTCA
chains in the Genus database with same CATH superfamily
2AYOA 2PNSA 2BTWB 3WXFA 2DOSA 2R9OA 3OF9A 4QBBA 3N3KA 3F5VA 3BY4A 5A24A 4PP1A 1HUCB 2VHFA 5EZQA 1TLOA 3K8UA 5E6JA 1TL9A 1NPZA 1NB3A 2J7QC 2WBFX 3I3TA 2G6DA 1AYVA 4PI3A 2ATOA 1UKFA 3H7DA 3IOQA 3GCBA 3BBAA 4CDFB 2DC9A 1QMYA 2FRAA 3B79A 1EWLA 4RF1A 1K3BB 3PRMA 3RVWA 2YJ2A 2R9MA 2HH5A 1PPOA 3RVXA 4BPVA 4P6EA 3F75A 1SP4B 2AU1A 2FT2A 2E00A 3KW9A 2BTWA 1Y08A 2GFOA 1KXRA 2E02A 5EZSA 1AU4A 3RNVA 1ME4A 3WXEA 5PADA 1KHQA 3H89A 3PBHA 3D6SA 4GUAA 4IP3A 3P5WA 1SNKA 3E1ZB 3ERVA 1DF0A 5JZEA 4OW0A 4P6GA 4I04A 1QOLA 2HHNA 5JA7A 2R9FA 1KFXL 4BOQA 4YYRA 4N79A 1MEGA 5CHVA 3QT4A 2BDLA 1MEMA 1QDQA 2DC6A 3QSDA 1Y4HA 1PXVA 4RF0A 4BOSA 4K7CA 3OF8A 2B1MA 4D8BA 2BU3A 1NQCA 1ME3A 1AECA 1NLJA 4CZWA 3IFUA 3KFQA 3S3RA 3W30A 1U9WA 3E9SA 1IWDA 4MM3B 1YALA 1AU2A 2AUZA 3BC3A 3MORA 1YZBA 4M0WA 3V6EA 4PT5A 4YVAA 1CB5A 2Z84A 1U9QX 2IPPB 4AXLA 2AUXA 4BQVA 3MTNA 3BB7A 1TU6A 3DF0A 3S3QA 3K9MA 4OEMA 2ACTA 3B21A 5JH3A 4CDDB 5EGWA 1AIMA 1PIPA 1PPPA 4ZTBA 1EF7A 3MHSA 3QJ3A 3PT2A 2P7UA 2XU5A 2DC7A 2JQFR 1F2CA 1CSBB 4QRXA 2HD5A 2F1GA 1F2AA 3N3GA 1EWMA 2P0RA 9PAPA 4DMXA 3PHXA 4MI7A 2DZZA 5CVOB 3MTVA 4YYVA 8PCHA 3CBKA 1YVBA 1THEA 3LFYA 1DKIA 3H8BA 2AYNA 2NQAA 1F29A 4HWYA 4XZXA 4YYSA 4MZSA 3O1GA 2Y5BA 2DCBA 2GHUA 3TRKA 4YYQA 1M6DA 5K16A 3H6SA 1ITOA 1F2BA 3OISA 1POPA 2E01A 2YJBA 4BS6A 1QXPA 2JRIA 2AGAA 3PHUA 4R3DA 3KWBX 2AS8A 4RKXA 1PPNA 2OP3A 3N4CA 1VSNA 1U5IA 2OZ2A 2HXZA 4DMYA 3M99A 2NQIA 2DCAA 2FE8A 4ZUXU 1ZIVA 2R9CA 6PADA 2O6XA 3P5XA 1BP4A 4REZA 1O0EA 3U8EA 1VJVA 1FH0A 4D8EA 1STFE 3PSEA 3RVVA 2JTCA 3I06A 4XR7A 4D8IA 2PBHA 4WA6A 1JQPA 2G7YA 1CS8A 1U9XA 4I07A 3TMPA 2IBIA 3MHHA 4OELA 2CIOA 2R9NA 4CDEB 4BSQA 1Q6KA 3AI8A 5CVMA 4YV8A 3HHIA 4G54A 1CTEA 4RY2A 2E03A 2DJGB 3ZNHA 7PCKA 3KKUA 1PVJA 2J7QA 1AU0A 3LXSA 4PADA 1KHPA 1GECE 2G8EA 2YJ9A 2NQGA 4AXMA 1AYUA 3O0UA 3CH2X 4Q8GA 1CQDA 2UZJA 3IUTA 3P5UA 1PPDA 1PBHA 3KX1A 1CVZA 2FO5A 2P86A 1CV8A 3HD3A 3KWZA 3P5VA 3NHEA 1CJLA 1XKGA 2FUDA 1YK8A 3OQCA 1AYWA 1BQIA 2FYEA 4BOUA 2YJ8A 3PNRA 4QH6A 2Y6EA 5EF4A 4XUIA 2OULA 2H7JA 3HWNA 1NB5A 1S4VA 4PP2E 5J94A 5CVNB 4BOZA 2AVWA 3O65A 3BCNA 2XU1A 1MHWA 1NL6A 2VHSA 3MJ5A 4FJCA 1A6RA 4YYWA 4YYUA 2FRQA 4FK5A 1BGOA 3K24A 3OVXA 3V6CA 1GMYA 3C9EA 2NQDB 3KSEA 2FQ9A 1ATKA 5KO3A 1EWPA 3WXGA 5FPWA 2DC8A 4CDCB 1DEUA 3HHAA 4KLBA 1KFUL 2PREA 3PHWA 3W31A 4Q8HA 2C0YA 3PRPA 4W5CA 3H8CA 4A5UA 4OVZB 4QRGA 1BY8A 2DJFB 1YT7A 4MZOA 3C0RA 4MSXA 2XU3A 4BS5A 2R6NA 3CBJA 1ZCMA 2AIMA 3IHPA 1U9VA 2B1NA 2FTDA 3IV2A 3BOWA 1MS6A 4N4ZA 2DCCA 2F7DA 3OVZA 3BPMA 2CB5A 1YK7A 4I05A 1PE6A 1EWOA 1MIRA 4X6IA 3PW3A 2DZYA 5F02A 2JQGR 3CH3X 1MDWA 4QRVA 4W5BA 4X6HA 3IMAA 2XU4A 2HWKA 3MP2A 2YJCA 5CHTA 1X9YA 3BPFA 4HXDB 2DCDA 1PCIA 1CPJA 4OVZA 1GCBA 2PADA 4P16A 3TNXA 1AU3A 4N8WA 4WURA 3USVA 4X6JA 3PDFA 1ICFA 3IEJA 2BDZA 2G8JA 4W4UA 1GLOA 2ARYA 4IUMA 4BOPA 3ZUAA 4FIPA 1PADA 4RNAA 3BWKA
chains in the Genus database with same CATH topology
2FE8A 2BTWB 3MJ5A 4M0WA 1YZBA 2DOSA 4PT5A 4REZA 2Z84A 3BY4A 5EZQA 5E6JA 4D8EA 2J7QC 3BB7A 5KO3A 3PSEA 2JTCA 1UKFA 3O65A 4D8IA 3B21A 3TMPA 3BBAA 3PHWA 3W31A 3PRPA 4A5UA 4RF1A 4OVZB 3PRMA 4ZTBA 3C0RA 3PT2A 3ZNHA 1PVJA 2BTWA 2J7QA 3PHXA 4MI7A 5EZSA 3RNVA 3MTVA 2UZJA 4GUAA 4IP3A 1DKIA 5JZEA 4OW0A 4XZXA 2HWKA 3MP2A 4HXDB 4OVZA 4BOQA 4P16A 3TRKA 3OQCA 4WURA 4RF0A 4BOSA 2JRIA 2AGAA 4BOUA 3PHUA 4R3DA 4D8BA 2BU3A 4RKXA 3IFUA 4IUMA 3W30A 4BOPA 4BOZA 3E9SA 4RNAA 4MM3B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8E A;  2UZJ A;  3BBA A;  4D8B A;  4D8I A;  1PVJ A;  3BB7 A;  4RKX A;  1DKI A;  2JTC A; 
#chains in the Genus database with same CATH topology
 2AYO A;  2PNS A;  2BTW B;  3WXF A;  2DOS A;  2R9O A;  3OF9 A;  4QBB A;  3N3K A;  3F5V A;  3BY4 A;  5A24 A;  4PP1 A;  1HUC B;  2VHF A;  5EZQ A;  1TLO A;  3K8U A;  5E6J A;  1TL9 A;  1NPZ A;  1NB3 A;  2J7Q C;  2WBF X;  3I3T A;  2G6D A;  1AYV A;  4PI3 A;  2ATO A;  1UKF A;  3H7D A;  3IOQ A;  3GCB A;  3BBA A;  4CDF B;  2DC9 A;  1QMY A;  2FRA A;  3B79 A;  1EWL A;  4RF1 A;  1K3B B;  3PRM A;  3RVW A;  2YJ2 A;  2R9M A;  2HH5 A;  1PPO A;  3RVX A;  4BPV A;  4P6E A;  3F75 A;  1SP4 B;  2AU1 A;  2FT2 A;  2E00 A;  3KW9 A;  2BTW A;  1Y08 A;  2GFO A;  1KXR A;  2E02 A;  5EZS A;  1AU4 A;  3RNV A;  1ME4 A;  3WXE A;  5PAD A;  1KHQ A;  3H89 A;  3PBH A;  3D6S A;  4GUA A;  4IP3 A;  3P5W A;  1SNK A;  3E1Z B;  3ERV A;  1DF0 A;  5JZE A;  4OW0 A;  4P6G A;  4I04 A;  1QOL A;  2HHN A;  5JA7 A;  2R9F A;  1KFX L;  4BOQ A;  4YYR A;  4N79 A;  1MEG A;  5CHV A;  3QT4 A;  2BDL A;  1MEM A;  1QDQ A;  2DC6 A;  3QSD A;  1Y4H A;  1PXV A;  4RF0 A;  4BOS A;  4K7C A;  3OF8 A;  2B1M A;  4D8B A;  2BU3 A;  1NQC A;  1ME3 A;  1AEC A;  1NLJ A;  4CZW A;  3IFU A;  3KFQ A;  3S3R A;  3W30 A;  1U9W A;  3E9S A;  1IWD A;  4MM3 B;  1YAL A;  1AU2 A;  2AUZ A;  3BC3 A;  3MOR A;  1YZB A;  4M0W A;  3V6E A;  4PT5 A;  4YVA A;  1CB5 A;  2Z84 A;  1U9Q X;  2IPP B;  4AXL A;  2AUX A;  4BQV A;  3MTN A;  3BB7 A;  1TU6 A;  3DF0 A;  3S3Q A;  3K9M A;  4OEM A;  2ACT A;  3B21 A;  5JH3 A;  4CDD B;  5EGW A;  1AIM A;  1PIP A;  1PPP A;  4ZTB A;  1EF7 A;  3MHS A;  3QJ3 A;  3PT2 A;  2P7U A;  2XU5 A;  2DC7 A;  2JQF R;  1F2C A;  1CSB B;  4QRX A;  2HD5 A;  2F1G A;  1F2A A;  3N3G A;  1EWM A;  2P0R A;  9PAP A;  4DMX A;  3PHX A;  4MI7 A;  2DZZ A;  5CVO B;  3MTV A;  4YYV A;  8PCH A;  3CBK A;  1YVB A;  1THE A;  3LFY A;  1DKI A;  3H8B A;  2AYN A;  2NQA A;  1F29 A;  4HWY A;  4XZX A;  4YYS A;  4MZS A;  3O1G A;  2Y5B A;  2DCB A;  2GHU A;  3TRK A;  4YYQ A;  1M6D A;  5K16 A;  3H6S A;  1ITO A;  1F2B A;  3OIS A;  1POP A;  2E01 A;  2YJB A;  4BS6 A;  1QXP A;  2JRI A;  2AGA A;  3PHU A;  4R3D A;  3KWB X;  2AS8 A;  4RKX A;  1PPN A;  2OP3 A;  3N4C A;  1VSN A;  1U5I A;  2OZ2 A;  2HXZ A;  4DMY A;  3M99 A;  2NQI A;  2DCA A;  2FE8 A;  4ZUX U;  1ZIV A;  2R9C A;  6PAD A;  2O6X A;  3P5X A;  1BP4 A;  4REZ A;  1O0E A;  3U8E A;  1VJV A;  1FH0 A;  4D8E A;  1STF E;  3PSE A;  3RVV A;  2JTC A;  3I06 A;  4XR7 A;  4D8I A;  2PBH A;  4WA6 A;  1JQP A;  2G7Y A;  1CS8 A;  1U9X A;  4I07 A;  3TMP A;  2IBI A;  3MHH A;  4OEL A;  2CIO A;  2R9N A;  4CDE B;  4BSQ A;  1Q6K A;  3AI8 A;  5CVM A;  4YV8 A;  3HHI A;  4G54 A;  1CTE A;  4RY2 A;  2E03 A;  2DJG B;  3ZNH A;  7PCK A;  3KKU A;  1PVJ A;  2J7Q A;  1AU0 A;  3LXS A;  4PAD A;  1KHP A;  1GEC E;  2G8E A;  2YJ9 A;  2NQG A;  4AXM A;  1AYU A;  3O0U A;  3CH2 X;  4Q8G A;  1CQD A;  2UZJ A;  3IUT A;  3P5U A;  1PPD A;  1PBH A;  3KX1 A;  1CVZ A;  2FO5 A;  2P86 A;  1CV8 A;  3HD3 A;  3KWZ A;  3P5V A;  3NHE A;  1CJL A;  1XKG A;  2FUD A;  1YK8 A;  3OQC A;  1AYW A;  1BQI A;  2FYE A;  4BOU A;  2YJ8 A;  3PNR A;  4QH6 A;  2Y6E A;  5EF4 A;  4XUI A;  2OUL A;  2H7J A;  3HWN A;  1NB5 A;  1S4V A;  4PP2 E;  5J94 A;  5CVN B;  4BOZ A;  2AVW A;  3O65 A;  3BCN A;  2XU1 A;  1MHW A;  1NL6 A;  2VHS A;  3MJ5 A;  4FJC A;  1A6R A;  4YYW A;  4YYU A;  2FRQ A;  4FK5 A;  1BGO A;  3K24 A;  3OVX A;  3V6C A;  1GMY A;  3C9E A;  2NQD B;  3KSE A;  2FQ9 A;  1ATK A;  5KO3 A;  1EWP A;  3WXG A;  5FPW A;  2DC8 A;  4CDC B;  1DEU A;  3HHA A;  4KLB A;  1KFU L;  2PRE A;  3PHW A;  3W31 A;  4Q8H A;  2C0Y A;  3PRP A;  4W5C A;  3H8C A;  4A5U A;  4OVZ B;  4QRG A;  1BY8 A;  2DJF B;  1YT7 A;  4MZO A;  3C0R A;  4MSX A;  2XU3 A;  4BS5 A;  2R6N A;  3CBJ A;  1ZCM A;  2AIM A;  3IHP A;  1U9V A;  2B1N A;  2FTD A;  3IV2 A;  3BOW A;  1MS6 A;  4N4Z A;  2DCC A;  2F7D A;  3OVZ A;  3BPM A;  2CB5 A;  1YK7 A;  4I05 A;  1PE6 A;  1EWO A;  1MIR A;  4X6I A;  3PW3 A;  2DZY A;  5F02 A;  2JQG R;  3CH3 X;  1MDW A;  4QRV A;  4W5B A;  4X6H A;  3IMA A;  2XU4 A;  2HWK A;  3MP2 A;  2YJC A;  5CHT A;  1X9Y A;  3BPF A;  4HXD B;  2DCD A;  1PCI A;  1CPJ A;  4OVZ A;  1GCB A;  2PAD A;  4P16 A;  3TNX A;  1AU3 A;  4N8W A;  4WUR A;  3USV A;  4X6J A;  3PDF A;  1ICF A;  3IEJ A;  2BDZ A;  2G8J A;  4W4U A;  1GLO A;  2ARY A;  4IUM A;  4BOP A;  3ZUA A;  4FIP A;  1PAD A;  4RNA A;  3BWK A; 
#chains in the Genus database with same CATH homology
 2FE8 A;  2BTW B;  3MJ5 A;  4M0W A;  1YZB A;  2DOS A;  4PT5 A;  4REZ A;  2Z84 A;  3BY4 A;  5EZQ A;  5E6J A;  4D8E A;  2J7Q C;  3BB7 A;  5KO3 A;  3PSE A;  2JTC A;  1UKF A;  3O65 A;  4D8I A;  3B21 A;  3TMP A;  3BBA A;  3PHW A;  3W31 A;  3PRP A;  4A5U A;  4RF1 A;  4OVZ B;  3PRM A;  4ZTB A;  3C0R A;  3PT2 A;  3ZNH A;  1PVJ A;  2BTW A;  2J7Q A;  3PHX A;  4MI7 A;  5EZS A;  3RNV A;  3MTV A;  2UZJ A;  4GUA A;  4IP3 A;  1DKI A;  5JZE A;  4OW0 A;  4XZX A;  2HWK A;  3MP2 A;  4HXD B;  4OVZ A;  4BOQ A;  4P16 A;  3TRK A;  3OQC A;  4WUR A;  4RF0 A;  4BOS A;  2JRI A;  2AGA A;  4BOU A;  3PHU A;  4R3D A;  4D8B A;  2BU3 A;  4RKX A;  3IFU A;  4IUM A;  3W30 A;  4BOP A;  4BOZ A;  3E9S A;  4RNA A;  4MM3 B; 
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similar chains in the Genus database (?% sequence similarity)
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