4D8EA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8eA00
1DKIA 1PVJA 4D8EA 4D8IA 3BBAA 4D8BA 3BB7A 4RKXA 2UZJA 2JTCA
chains in the Genus database with same CATH superfamily
3OVXA 1HUCB 4BPVA 1CQDA 1CJLA 2YJ9A 3LXSA 2NQDB 3HHIA 1EWLA 1VJVA 4N79A 1YVBA 1PIPA 2CB5A 2P86A 1A6RA 4MM3B 4X6JA 1PPDA 1BP4A 1SP4B 4FK5A 2DJFB 4ZTBA 1GECE 3OQCA 3PDFA 4QRXA 3C9EA 4QRVA 5FPWA 2DJGB 3O1GA 3H89A 3P5WA 4PP2E 4CDDB 2FTDA 1MS6A 1VSNA 1YALA 2DCBA 3RNVA 2JQFR 1NLJA 3KX1A 2FO5A 4D8EA 3M99A 3E1ZB 2R9OA 1TL9A 4HWYA 3CBKA 4YYQA 3RVWA 1TLOA 1FH0A 3RVXA 1CTEA 2FE8A 4W5CA 2ATOA 2DC8A 4IUMA 3MTNA 1GMYA 4XZXA 3NHEA 2R9NA 2P0RA 2G6DA 2R9FA 2XU4A 5JH3A 2DZYA 1AYUA 1AYVA 4BOPA 3N3GA 1EWPA 2AYOA 1IWDA 3BC3A 3PHXA 3AI8A 4QBBA 3ERVA 4DMXA 1ITOA 1MDWA 1ME3A 2DC9A 3TRKA 4YYWA 1QXPA 4GUAA 1PVJA 3IOQA 3BBAA 4P16A 5EZSA 5K16A 3MHSA 1ZCMA 1X9YA 3KWBX 2XU5A 4AXMA 2YJ2A 2JQGR 3IUTA 3BOWA 3MORA 4IP3A 1EWOA 2E02A 2C0YA 1AU0A 3TMPA 4W4UA 4MZOA 2DOSA 1YK8A 4M0WA 3I06A 1AU3A 1PCIA 3S3RA 4OVZA 4FJCA 1KFUL 2FRQA 2YJCA 5EZQA 3W31A 1PPOA 1NL6A 4BSQA 3PW3A 1S4VA 3B21A 5CVMA 2OP3A 1NQCA 4Q8GA 3MTVA 1AYWA 1KFXL 2AVWA 5CVOB 3MP2A 3H8BA 1MIRA 1EF7A 4K7CA 1KHPA 4R3DA 2GFOA 3WXGA 2BDLA 1AU4A 1MEMA 4BOSA 4BS5A 1BY8A 4PT5A 3HD3A 2B1MA 1GCBA 3OISA 4I07A 2AIMA 5JZEA 4QRGA 3MHHA 1ME4A 3PRPA 6PADA 1U9WA 2BDZA 2FYEA 2PREA 4MI7A 1DEUA 3IMAA 1PADA 2G8JA 1DKIA 7PCKA 1ICFA 1PPNA 3P5VA 5F02A 4RF0A 3F75A 3H6SA 3PNRA 5CVNB 1U9VA 3V6CA 1NPZA 2E01A 3PSEA 3ZNHA 3WXEA 4YV8A 2DC6A 4DMYA 4P6GA 1NB3A 2G7YA 4N4ZA 5CHTA 3HWNA 3LFYA 2GHUA 5JA7A 4OW0A 1GLOA 4G54A 2DZZA 3PHWA 2BTWB 1U9XA 3BCNA 3GCBA 3D6SA 1YZBA 3BY4A 4A5UA 1F2BA 1KXRA 1O0EA 3K8UA 3QSDA 3F5VA 4OELA 2HD5A 3PBHA 3I3TA 1AECA 4ZUXU 2ACTA 1QOLA 1Y4HA 5A24A 3OF8A 4HXDB 2AUZA 3N3KA 2F7DA 1THEA 3E9SA 3KW9A 2JTCA 3KKUA 1CVZA 2PADA 3DF0A 1JQPA 4PP1A 2PNSA 4W5BA 2WBFX 3IEJA 1F29A 4X6IA 4RF1A 1CS8A 4OEMA 1YT7A 1AU2A 2OZ2A 1U9QX 4YYUA 2J7QA 2YJ8A 2NQAA 3KWZA 4X6HA 1ATKA 2OULA 3OVZA 1BQIA 2IBIA 4RY2A 3KFQA 3IFUA 1TU6A 2BTWA 5CHVA 1EWMA 1Q6KA 3BPFA 3CBJA 4Q8HA 3QT4A 3C0RA 3U8EA 3OF9A 2AYNA 4FIPA 4YVAA 1QMYA 3IV2A 5E6JA 4I05A 4RKXA 1QDQA 2Y6EA 2HH5A 2FT2A 2G8EA 5EGWA 4KLBA 4RNAA 4PADA 1MHWA 3HHAA 3MJ5A 3P5UA 3PHUA 2AGAA 1CB5A 2YJBA 5J94A 2R9CA 2AS8A 3K9MA 1UKFA 4CZWA 1F2CA 1PE6A 1DF0A 2Y5BA 4XR7A 2FRAA 4OVZB 2PBHA 8PCHA 4XUIA 2E00A 2NQGA 4BS6A 2DCDA 4CDFB 2R6NA 3BPMA 4PI3A 2FUDA 4YYRA 1U5IA 2DC7A 1STFE 4WURA 4YYSA 2F1GA 2Z84A 1CSBB 2AUXA 4BQVA 4MZSA 1PXVA 4N8WA 2NQIA 1NB5A 1BGOA 4BOQA 2BU3A 3V6EA 3KSEA 1AIMA 9PAPA 4QH6A 4CDEB 4D8IA 2JRIA 1K3BB 1F2AA 3IHPA 1M6DA 3BB7A 1Y08A 3USVA 3BWKA 3CH3X 3QJ3A 4MSXA 3O65A 3WXFA 3PRMA 2DCCA 2O6XA 1KHQA 5PADA 4BOZA 3B79A 3CH2X 4P6EA 1YK7A 2XU3A 1XKGA 2VHFA 1PBHA 4CDCB 1MEGA 3N4CA 4AXLA 2DCAA 3P5XA 2CIOA 2UZJA 4I04A 2B1NA 3RVVA 1CV8A 2R9MA 1ZIVA 3S3QA 1POPA 3ZUAA 3K24A 3H8CA 3TNXA 2HXZA 3O0UA 3PT2A 2H7JA 2HWKA 1SNKA 4WA6A 4YYVA 2IPPB 4D8BA 5EF4A 2P7UA 1PPPA 3W30A 4REZA 2FQ9A 2XU1A 2ARYA 2E03A 2J7QC 5KO3A 3H7DA 2AU1A 4BOUA 2HHNA 2VHSA 1CPJA
chains in the Genus database with same CATH topology
4M0WA 4HXDB 3E9SA 4OVZB 2JTCA 4OVZA 5EZQA 3W31A 4MM3B 3B21A 3MTVA 4WURA 2Z84A 4ZTBA 4RF1A 3MP2A 3OQCA 4R3DA 4BOQA 2J7QA 2BU3A 4BOSA 4PT5A 3RNVA 4D8IA 2JRIA 4D8EA 5JZEA 3BB7A 3PRPA 4MI7A 3O65A 2FE8A 3IFUA 4IUMA 1DKIA 2BTWA 4XZXA 3PRMA 4BOZA 4RF0A 3C0RA 4BOPA 3PHXA 5E6JA 3PSEA 3ZNHA 4RKXA 2UZJA 3TRKA 4OW0A 4RNAA 4GUAA 3PHWA 2BTWB 1PVJA 3MJ5A 3PHUA 3BBAA 4P16A 5EZSA 2AGAA 3PT2A 1YZBA 3BY4A 2HWKA 4A5UA 4IP3A 4D8BA 3W30A 1UKFA 4REZA 3TMPA 2J7QC 5KO3A 2DOSA 4BOUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DKI A;  1PVJ A;  4D8E A;  4D8I A;  3BBA A;  4D8B A;  3BB7 A;  4RKX A;  2UZJ A;  2JTC A; 
#chains in the Genus database with same CATH topology
 3OVX A;  1HUC B;  4BPV A;  1CQD A;  1CJL A;  2YJ9 A;  3LXS A;  2NQD B;  3HHI A;  1EWL A;  1VJV A;  4N79 A;  1YVB A;  1PIP A;  2CB5 A;  2P86 A;  1A6R A;  4MM3 B;  4X6J A;  1PPD A;  1BP4 A;  1SP4 B;  4FK5 A;  2DJF B;  4ZTB A;  1GEC E;  3OQC A;  3PDF A;  4QRX A;  3C9E A;  4QRV A;  5FPW A;  2DJG B;  3O1G A;  3H89 A;  3P5W A;  4PP2 E;  4CDD B;  2FTD A;  1MS6 A;  1VSN A;  1YAL A;  2DCB A;  3RNV A;  2JQF R;  1NLJ A;  3KX1 A;  2FO5 A;  4D8E A;  3M99 A;  3E1Z B;  2R9O A;  1TL9 A;  4HWY A;  3CBK A;  4YYQ A;  3RVW A;  1TLO A;  1FH0 A;  3RVX A;  1CTE A;  2FE8 A;  4W5C A;  2ATO A;  2DC8 A;  4IUM A;  3MTN A;  1GMY A;  4XZX A;  3NHE A;  2R9N A;  2P0R A;  2G6D A;  2R9F A;  2XU4 A;  5JH3 A;  2DZY A;  1AYU A;  1AYV A;  4BOP A;  3N3G A;  1EWP A;  2AYO A;  1IWD A;  3BC3 A;  3PHX A;  3AI8 A;  4QBB A;  3ERV A;  4DMX A;  1ITO A;  1MDW A;  1ME3 A;  2DC9 A;  3TRK A;  4YYW A;  1QXP A;  4GUA A;  1PVJ A;  3IOQ A;  3BBA A;  4P16 A;  5EZS A;  5K16 A;  3MHS A;  1ZCM A;  1X9Y A;  3KWB X;  2XU5 A;  4AXM A;  2YJ2 A;  2JQG R;  3IUT A;  3BOW A;  3MOR A;  4IP3 A;  1EWO A;  2E02 A;  2C0Y A;  1AU0 A;  3TMP A;  4W4U A;  4MZO A;  2DOS A;  1YK8 A;  4M0W A;  3I06 A;  1AU3 A;  1PCI A;  3S3R A;  4OVZ A;  4FJC A;  1KFU L;  2FRQ A;  2YJC A;  5EZQ A;  3W31 A;  1PPO A;  1NL6 A;  4BSQ A;  3PW3 A;  1S4V A;  3B21 A;  5CVM A;  2OP3 A;  1NQC A;  4Q8G A;  3MTV A;  1AYW A;  1KFX L;  2AVW A;  5CVO B;  3MP2 A;  3H8B A;  1MIR A;  1EF7 A;  4K7C A;  1KHP A;  4R3D A;  2GFO A;  3WXG A;  2BDL A;  1AU4 A;  1MEM A;  4BOS A;  4BS5 A;  1BY8 A;  4PT5 A;  3HD3 A;  2B1M A;  1GCB A;  3OIS A;  4I07 A;  2AIM A;  5JZE A;  4QRG A;  3MHH A;  1ME4 A;  3PRP A;  6PAD A;  1U9W A;  2BDZ A;  2FYE A;  2PRE A;  4MI7 A;  1DEU A;  3IMA A;  1PAD A;  2G8J A;  1DKI A;  7PCK A;  1ICF A;  1PPN A;  3P5V A;  5F02 A;  4RF0 A;  3F75 A;  3H6S A;  3PNR A;  5CVN B;  1U9V A;  3V6C A;  1NPZ A;  2E01 A;  3PSE A;  3ZNH A;  3WXE A;  4YV8 A;  2DC6 A;  4DMY A;  4P6G A;  1NB3 A;  2G7Y A;  4N4Z A;  5CHT A;  3HWN A;  3LFY A;  2GHU A;  5JA7 A;  4OW0 A;  1GLO A;  4G54 A;  2DZZ A;  3PHW A;  2BTW B;  1U9X A;  3BCN A;  3GCB A;  3D6S A;  1YZB A;  3BY4 A;  4A5U A;  1F2B A;  1KXR A;  1O0E A;  3K8U A;  3QSD A;  3F5V A;  4OEL A;  2HD5 A;  3PBH A;  3I3T A;  1AEC A;  4ZUX U;  2ACT A;  1QOL A;  1Y4H A;  5A24 A;  3OF8 A;  4HXD B;  2AUZ A;  3N3K A;  2F7D A;  1THE A;  3E9S A;  3KW9 A;  2JTC A;  3KKU A;  1CVZ A;  2PAD A;  3DF0 A;  1JQP A;  4PP1 A;  2PNS A;  4W5B A;  2WBF X;  3IEJ A;  1F29 A;  4X6I A;  4RF1 A;  1CS8 A;  4OEM A;  1YT7 A;  1AU2 A;  2OZ2 A;  1U9Q X;  4YYU A;  2J7Q A;  2YJ8 A;  2NQA A;  3KWZ A;  4X6H A;  1ATK A;  2OUL A;  3OVZ A;  1BQI A;  2IBI A;  4RY2 A;  3KFQ A;  3IFU A;  1TU6 A;  2BTW A;  5CHV A;  1EWM A;  1Q6K A;  3BPF A;  3CBJ A;  4Q8H A;  3QT4 A;  3C0R A;  3U8E A;  3OF9 A;  2AYN A;  4FIP A;  4YVA A;  1QMY A;  3IV2 A;  5E6J A;  4I05 A;  4RKX A;  1QDQ A;  2Y6E A;  2HH5 A;  2FT2 A;  2G8E A;  5EGW A;  4KLB A;  4RNA A;  4PAD A;  1MHW A;  3HHA A;  3MJ5 A;  3P5U A;  3PHU A;  2AGA A;  1CB5 A;  2YJB A;  5J94 A;  2R9C A;  2AS8 A;  3K9M A;  1UKF A;  4CZW A;  1F2C A;  1PE6 A;  1DF0 A;  2Y5B A;  4XR7 A;  2FRA A;  4OVZ B;  2PBH A;  8PCH A;  4XUI A;  2E00 A;  2NQG A;  4BS6 A;  2DCD A;  4CDF B;  2R6N A;  3BPM A;  4PI3 A;  2FUD A;  4YYR A;  1U5I A;  2DC7 A;  1STF E;  4WUR A;  4YYS A;  2F1G A;  2Z84 A;  1CSB B;  2AUX A;  4BQV A;  4MZS A;  1PXV A;  4N8W A;  2NQI A;  1NB5 A;  1BGO A;  4BOQ A;  2BU3 A;  3V6E A;  3KSE A;  1AIM A;  9PAP A;  4QH6 A;  4CDE B;  4D8I A;  2JRI A;  1K3B B;  1F2A A;  3IHP A;  1M6D A;  3BB7 A;  1Y08 A;  3USV A;  3BWK A;  3CH3 X;  3QJ3 A;  4MSX A;  3O65 A;  3WXF A;  3PRM A;  2DCC A;  2O6X A;  1KHQ A;  5PAD A;  4BOZ A;  3B79 A;  3CH2 X;  4P6E A;  1YK7 A;  2XU3 A;  1XKG A;  2VHF A;  1PBH A;  4CDC B;  1MEG A;  3N4C A;  4AXL A;  2DCA A;  3P5X A;  2CIO A;  2UZJ A;  4I04 A;  2B1N A;  3RVV A;  1CV8 A;  2R9M A;  1ZIV A;  3S3Q A;  1POP A;  3ZUA A;  3K24 A;  3H8C A;  3TNX A;  2HXZ A;  3O0U A;  3PT2 A;  2H7J A;  2HWK A;  1SNK A;  4WA6 A;  4YYV A;  2IPP B;  4D8B A;  5EF4 A;  2P7U A;  1PPP A;  3W30 A;  4REZ A;  2FQ9 A;  2XU1 A;  2ARY A;  2E03 A;  2J7Q C;  5KO3 A;  3H7D A;  2AU1 A;  4BOU A;  2HHN A;  2VHS A;  1CPJ A; 
#chains in the Genus database with same CATH homology
 4M0W A;  4HXD B;  3E9S A;  4OVZ B;  2JTC A;  4OVZ A;  5EZQ A;  3W31 A;  4MM3 B;  3B21 A;  3MTV A;  4WUR A;  2Z84 A;  4ZTB A;  4RF1 A;  3MP2 A;  3OQC A;  4R3D A;  4BOQ A;  2J7Q A;  2BU3 A;  4BOS A;  4PT5 A;  3RNV A;  4D8I A;  2JRI A;  4D8E A;  5JZE A;  3BB7 A;  3PRP A;  4MI7 A;  3O65 A;  2FE8 A;  3IFU A;  4IUM A;  1DKI A;  2BTW A;  4XZX A;  3PRM A;  4BOZ A;  4RF0 A;  3C0R A;  4BOP A;  3PHX A;  5E6J A;  3PSE A;  3ZNH A;  4RKX A;  2UZJ A;  3TRK A;  4OW0 A;  4RNA A;  4GUA A;  3PHW A;  2BTW B;  1PVJ A;  3MJ5 A;  3PHU A;  3BBA A;  4P16 A;  5EZS A;  2AGA A;  3PT2 A;  1YZB A;  3BY4 A;  2HWK A;  4A5U A;  4IP3 A;  4D8B A;  3W30 A;  1UKF A;  4REZ A;  3TMP A;  2J7Q C;  5KO3 A;  2DOS A;  4BOU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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