4D8IA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Streptococcus pyogenes
molecule keywords Streptopain
total genus 81
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8iA00
4D8IA 3BBAA 1DKIA 1PVJA 2JTCA 4D8BA 4D8EA 4RKXA 2UZJA 3BB7A
chains in the Genus database with same CATH superfamily
2DJFB 4N4ZA 1PPPA 4RY2A 1PXVA 1SP4B 4YYQA 1CS8A 3TMPA 1CVZA 1U9VA 4W5CA 4BOUA 2FT2A 1MEGA 3N3KA 3AI8A 1TU6A 2E03A 2AIMA 1DEUA 2AYNA 2AS8A 1TLOA 4PADA 5KO3A 3IMAA 4XR7A 2HWKA 5PADA 4I04A 2CIOA 2B1NA 1BY8A 5A24A 2FE8A 3V6CA 4XZXA 4FJCA 1KXRA 3H8BA 2J7QA 4MSXA 1AYUA 3BPFA 2FYEA 4YVAA 5E6JA 4Q8GA 3DF0A 4OW0A 4PP2E 7PCKA 4BOQA 4YYRA 1DKIA 2R9NA 3HD3A 2PREA 3RVVA 2JRIA 2P7UA 2NQDB 4RF1A 2OP3A 5CHTA 2YJ2A 2E01A 3IV2A 4CDCB 3HWNA 3MTNA 1M6DA 3PBHA 1HUCB 1S4VA 3OF8A 3BPMA 1XKGA 5JA7A 2R9MA 3PDFA 3CBJA 3BBAA 3D6SA 1AU4A 4YYVA 1IWDA 2AVWA 4X6IA 1Y08A 1K3BB 2XU4A 3OISA 2DZZA 4QRGA 3U8EA 2F1GA 2P0RA 2YJ9A 3RVWA 1MS6A 3LXSA 4DMXA 2G7YA 4W4UA 4BOPA 1AU0A 3KSEA 3PW3A 1PPOA 4N8WA 3BWKA 4X6JA 1YZBA 2R6NA 3TNXA 2R9FA 3PT2A 3BOWA 4BS6A 3IOQA 3IHPA 4BOSA 4CDEB 4AXMA 1PPDA 2VHSA 2HHNA 3CBKA 4YYSA 4HXDB 4K7CA 2DOSA 3QJ3A 8PCHA 2P86A 1YVBA 1QOLA 2FQ9A 2BDZA 2G8EA 3NHEA 2DC7A 1U9QX 5EF4A 2AYOA 2G8JA 2AU1A 4YYWA 2OULA 4OELA 5EZQA 2XU3A 2PBHA 3S3QA 1YT7A 2PNSA 3P5XA 1MEMA 4WURA 2GHUA 4W5BA 2WBFX 2BU3A 2NQGA 1ITOA 1NL6A 4PP1A 3B21A 3HHIA 4CDDB 4G54A 1PPNA 1CQDA 1YK8A 9PAPA 4ZUXU 2XU1A 3PNRA 4BPVA 1YALA 3N3GA 2J7QC 1U5IA 1GECE 3KKUA 1CV8A 5JH3A 1PE6A 2B1MA 1U9WA 1UKFA 4I07A 1EWPA 2BTWB 3BC3A 4QRVA 2ATOA 2BTWA 5F02A 3K24A 3MP2A 4ZTBA 4QRXA 1EWLA 1A6RA 3PHUA 4RKXA 2HD5A 1NPZA 2JQFR 3WXFA 4A5UA 1X9YA 4M0WA 2GFOA 4MZOA 1EWMA 2VHFA 5JZEA 3LFYA 2H7JA 4I05A 1PCIA 4R3DA 2HH5A 3MJ5A 4FK5A 3PHXA 4CDFB 2IBIA 3MTVA 2Z84A 5K16A 1EF7A 1PVJA 1TL9A 3USVA 2DCBA 1VSNA 2DCAA 4MI7A 3BB7A 2FRQA 3OVZA 1U9XA 3ZNHA 3OF9A 3O65A 1PADA 1PIPA 1BQIA 4YV8A 3IFUA 1DF0A 3O0UA 3P5UA 2XU5A 1F2BA 4IUMA 1ZIVA 3IEJA 1QDQA 3C0RA 2FUDA 3PHWA 4AXLA 3RVXA 1VJVA 1Q6KA 1ATKA 2Y5BA 3MORA 1Y4HA 1CB5A 2AUXA 2AUZA 3WXGA 3GCBA 4QH6A 3OVXA 3S3RA 4XUIA 1GMYA 5FPWA 4BSQA 2DCCA 4QBBA 3BY4A 4FIPA 3V6EA 1GCBA 1NB3A 3K8UA 2CB5A 1AU2A 2JQGR 2FO5A 1MDWA 1F2CA 1KFUL 3RNVA 3B79A 1STFE 3I3TA 4OVZB 2Y6EA 1YK7A 3IUTA 4OVZA 3F5VA 3CH3X 2DC8A 1QXPA 2C0YA 4BQVA 2DZYA 2FTDA 3C9EA 4P16A 1AYWA 4BS5A 3ERVA 3P5VA 5CVOB 1O0EA 3BCNA 4PT5A 4RF0A 2FRAA 5EGWA 1CJLA 4YYUA 5EZSA 4IP3A 1PBHA 2DC9A 2JTCA 3E1ZB 3H89A 2UZJA 3QSDA 1MHWA 1GLOA 3KWZA 4D8EA 4REZA 4MZSA 2F7DA 1KHQA 1ME3A 3W31A 4DMYA 2YJBA 4BOZA 3PSEA 3K9MA 3H7DA 4HWYA 3PRPA 1ME4A 1CSBB 3QT4A 1JQPA 1NQCA 3KX1A 4WA6A 1THEA 1AIMA 2ACTA 2R9CA 4P6EA 4D8BA 3I06A 3M99A 3MHSA 4D8IA 2HXZA 1CPJA 2O6XA 3N4CA 2NQIA 1SNKA 3OQCA 1ICFA 2E00A 2DJGB 3MHHA 3PRMA 4N79A 1F2AA 2BDLA 3HHAA 3KW9A 2NQAA 3E9SA 3H8CA 1NB5A 4X6HA 2E02A 1FH0A 3F75A 1QMYA 2OZ2A 6PADA 5CVNB 1AU3A 1BP4A 1MIRA 4CZWA 2DC6A 4Q8HA 4MM3B 1KHPA 1F29A 1AECA 3KWBX 2G6DA 3CH2X 4OEMA 3P5WA 5CHVA 4PI3A 4P6GA 1CTEA 1AYVA 3WXEA 1BGOA 1POPA 3O1GA 3KFQA 3TRKA 1NLJA 4GUAA 3ZUAA 2DCDA 2YJ8A 2IPPB 4KLBA 1KFXL 2ARYA 5J94A 2AGAA 3W30A 2YJCA 1EWOA 4RNAA 3H6SA 5CVMA 2R9OA 2PADA 1ZCMA
chains in the Genus database with same CATH topology
3MJ5A 3PHXA 4D8EA 4REZA 3MTVA 2Z84A 3W31A 1PVJA 4BOPA 3TMPA 4BOZA 4BOUA 3PSEA 4MI7A 3PRPA 3BB7A 1YZBA 3PT2A 3ZNHA 5KO3A 3O65A 4BOSA 3IFUA 4IUMA 4D8BA 2HWKA 4D8IA 3C0RA 4HXDB 2DOSA 3PHWA 2FE8A 3OQCA 4XZXA 3PRMA 2J7QA 5EZQA 3E9SA 5E6JA 4OW0A 3BY4A 4WURA 4BOQA 2BU3A 3B21A 1DKIA 2JRIA 4MM3B 3RNVA 4RF1A 2J7QC 4OVZB 4OVZA 1UKFA 2BTWB 3TRKA 2BTWA 4GUAA 4P16A 3MP2A 4ZTBA 3BBAA 2AGAA 3W30A 4PT5A 3PHUA 4RKXA 4RF0A 4A5UA 4M0WA 5EZSA 4IP3A 4RNAA 2JTCA 5JZEA 2UZJA 4R3DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  3BBA A;  1DKI A;  1PVJ A;  2JTC A;  4D8B A;  4D8E A;  4RKX A;  2UZJ A;  3BB7 A; 
#chains in the Genus database with same CATH topology
 2DJF B;  4N4Z A;  1PPP A;  4RY2 A;  1PXV A;  1SP4 B;  4YYQ A;  1CS8 A;  3TMP A;  1CVZ A;  1U9V A;  4W5C A;  4BOU A;  2FT2 A;  1MEG A;  3N3K A;  3AI8 A;  1TU6 A;  2E03 A;  2AIM A;  1DEU A;  2AYN A;  2AS8 A;  1TLO A;  4PAD A;  5KO3 A;  3IMA A;  4XR7 A;  2HWK A;  5PAD A;  4I04 A;  2CIO A;  2B1N A;  1BY8 A;  5A24 A;  2FE8 A;  3V6C A;  4XZX A;  4FJC A;  1KXR A;  3H8B A;  2J7Q A;  4MSX A;  1AYU A;  3BPF A;  2FYE A;  4YVA A;  5E6J A;  4Q8G A;  3DF0 A;  4OW0 A;  4PP2 E;  7PCK A;  4BOQ A;  4YYR A;  1DKI A;  2R9N A;  3HD3 A;  2PRE A;  3RVV A;  2JRI A;  2P7U A;  2NQD B;  4RF1 A;  2OP3 A;  5CHT A;  2YJ2 A;  2E01 A;  3IV2 A;  4CDC B;  3HWN A;  3MTN A;  1M6D A;  3PBH A;  1HUC B;  1S4V A;  3OF8 A;  3BPM A;  1XKG A;  5JA7 A;  2R9M A;  3PDF A;  3CBJ A;  3BBA A;  3D6S A;  1AU4 A;  4YYV A;  1IWD A;  2AVW A;  4X6I A;  1Y08 A;  1K3B B;  2XU4 A;  3OIS A;  2DZZ A;  4QRG A;  3U8E A;  2F1G A;  2P0R A;  2YJ9 A;  3RVW A;  1MS6 A;  3LXS A;  4DMX A;  2G7Y A;  4W4U A;  4BOP A;  1AU0 A;  3KSE A;  3PW3 A;  1PPO A;  4N8W A;  3BWK A;  4X6J A;  1YZB A;  2R6N A;  3TNX A;  2R9F A;  3PT2 A;  3BOW A;  4BS6 A;  3IOQ A;  3IHP A;  4BOS A;  4CDE B;  4AXM A;  1PPD A;  2VHS A;  2HHN A;  3CBK A;  4YYS A;  4HXD B;  4K7C A;  2DOS A;  3QJ3 A;  8PCH A;  2P86 A;  1YVB A;  1QOL A;  2FQ9 A;  2BDZ A;  2G8E A;  3NHE A;  2DC7 A;  1U9Q X;  5EF4 A;  2AYO A;  2G8J A;  2AU1 A;  4YYW A;  2OUL A;  4OEL A;  5EZQ A;  2XU3 A;  2PBH A;  3S3Q A;  1YT7 A;  2PNS A;  3P5X A;  1MEM A;  4WUR A;  2GHU A;  4W5B A;  2WBF X;  2BU3 A;  2NQG A;  1ITO A;  1NL6 A;  4PP1 A;  3B21 A;  3HHI A;  4CDD B;  4G54 A;  1PPN A;  1CQD A;  1YK8 A;  9PAP A;  4ZUX U;  2XU1 A;  3PNR A;  4BPV A;  1YAL A;  3N3G A;  2J7Q C;  1U5I A;  1GEC E;  3KKU A;  1CV8 A;  5JH3 A;  1PE6 A;  2B1M A;  1U9W A;  1UKF A;  4I07 A;  1EWP A;  2BTW B;  3BC3 A;  4QRV A;  2ATO A;  2BTW A;  5F02 A;  3K24 A;  3MP2 A;  4ZTB A;  4QRX A;  1EWL A;  1A6R A;  3PHU A;  4RKX A;  2HD5 A;  1NPZ A;  2JQF R;  3WXF A;  4A5U A;  1X9Y A;  4M0W A;  2GFO A;  4MZO A;  1EWM A;  2VHF A;  5JZE A;  3LFY A;  2H7J A;  4I05 A;  1PCI A;  4R3D A;  2HH5 A;  3MJ5 A;  4FK5 A;  3PHX A;  4CDF B;  2IBI A;  3MTV A;  2Z84 A;  5K16 A;  1EF7 A;  1PVJ A;  1TL9 A;  3USV A;  2DCB A;  1VSN A;  2DCA A;  4MI7 A;  3BB7 A;  2FRQ A;  3OVZ A;  1U9X A;  3ZNH A;  3OF9 A;  3O65 A;  1PAD A;  1PIP A;  1BQI A;  4YV8 A;  3IFU A;  1DF0 A;  3O0U A;  3P5U A;  2XU5 A;  1F2B A;  4IUM A;  1ZIV A;  3IEJ A;  1QDQ A;  3C0R A;  2FUD A;  3PHW A;  4AXL A;  3RVX A;  1VJV A;  1Q6K A;  1ATK A;  2Y5B A;  3MOR A;  1Y4H A;  1CB5 A;  2AUX A;  2AUZ A;  3WXG A;  3GCB A;  4QH6 A;  3OVX A;  3S3R A;  4XUI A;  1GMY A;  5FPW A;  4BSQ A;  2DCC A;  4QBB A;  3BY4 A;  4FIP A;  3V6E A;  1GCB A;  1NB3 A;  3K8U A;  2CB5 A;  1AU2 A;  2JQG R;  2FO5 A;  1MDW A;  1F2C A;  1KFU L;  3RNV A;  3B79 A;  1STF E;  3I3T A;  4OVZ B;  2Y6E A;  1YK7 A;  3IUT A;  4OVZ A;  3F5V A;  3CH3 X;  2DC8 A;  1QXP A;  2C0Y A;  4BQV A;  2DZY A;  2FTD A;  3C9E A;  4P16 A;  1AYW A;  4BS5 A;  3ERV A;  3P5V A;  5CVO B;  1O0E A;  3BCN A;  4PT5 A;  4RF0 A;  2FRA A;  5EGW A;  1CJL A;  4YYU A;  5EZS A;  4IP3 A;  1PBH A;  2DC9 A;  2JTC A;  3E1Z B;  3H89 A;  2UZJ A;  3QSD A;  1MHW A;  1GLO A;  3KWZ A;  4D8E A;  4REZ A;  4MZS A;  2F7D A;  1KHQ A;  1ME3 A;  3W31 A;  4DMY A;  2YJB A;  4BOZ A;  3PSE A;  3K9M A;  3H7D A;  4HWY A;  3PRP A;  1ME4 A;  1CSB B;  3QT4 A;  1JQP A;  1NQC A;  3KX1 A;  4WA6 A;  1THE A;  1AIM A;  2ACT A;  2R9C A;  4P6E A;  4D8B A;  3I06 A;  3M99 A;  3MHS A;  4D8I A;  2HXZ A;  1CPJ A;  2O6X A;  3N4C A;  2NQI A;  1SNK A;  3OQC A;  1ICF A;  2E00 A;  2DJG B;  3MHH A;  3PRM A;  4N79 A;  1F2A A;  2BDL A;  3HHA A;  3KW9 A;  2NQA A;  3E9S A;  3H8C A;  1NB5 A;  4X6H A;  2E02 A;  1FH0 A;  3F75 A;  1QMY A;  2OZ2 A;  6PAD A;  5CVN B;  1AU3 A;  1BP4 A;  1MIR A;  4CZW A;  2DC6 A;  4Q8H A;  4MM3 B;  1KHP A;  1F29 A;  1AEC A;  3KWB X;  2G6D A;  3CH2 X;  4OEM A;  3P5W A;  5CHV A;  4PI3 A;  4P6G A;  1CTE A;  1AYV A;  3WXE A;  1BGO A;  1POP A;  3O1G A;  3KFQ A;  3TRK A;  1NLJ A;  4GUA A;  3ZUA A;  2DCD A;  2YJ8 A;  2IPP B;  4KLB A;  1KFX L;  2ARY A;  5J94 A;  2AGA A;  3W30 A;  2YJC A;  1EWO A;  4RNA A;  3H6S A;  5CVM A;  2R9O A;  2PAD A;  1ZCM A; 
#chains in the Genus database with same CATH homology
 3MJ5 A;  3PHX A;  4D8E A;  4REZ A;  3MTV A;  2Z84 A;  3W31 A;  1PVJ A;  4BOP A;  3TMP A;  4BOZ A;  4BOU A;  3PSE A;  4MI7 A;  3PRP A;  3BB7 A;  1YZB A;  3PT2 A;  3ZNH A;  5KO3 A;  3O65 A;  4BOS A;  3IFU A;  4IUM A;  4D8B A;  2HWK A;  4D8I A;  3C0R A;  4HXD B;  2DOS A;  3PHW A;  2FE8 A;  3OQC A;  4XZX A;  3PRM A;  2J7Q A;  5EZQ A;  3E9S A;  5E6J A;  4OW0 A;  3BY4 A;  4WUR A;  4BOQ A;  2BU3 A;  3B21 A;  1DKI A;  2JRI A;  4MM3 B;  3RNV A;  4RF1 A;  2J7Q C;  4OVZ B;  4OVZ A;  1UKF A;  2BTW B;  3TRK A;  2BTW A;  4GUA A;  4P16 A;  3MP2 A;  4ZTB A;  3BBA A;  2AGA A;  3W30 A;  4PT5 A;  3PHU A;  4RKX A;  4RF0 A;  4A5U A;  4M0W A;  5EZS A;  4IP3 A;  4RNA A;  2JTC A;  5JZE A;  2UZJ A;  4R3D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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