4HXDB

Diversity of ubiquitin and isg15 specificity amongst nairoviruses viral ovarian tumor domain proteases
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
157
structure length
157
Chain Sequence
DFLDSLIWERVVDEQYITNPTFCVSDYFEVIRQPGDGNCFYHSIAELFFDVKTPSSFRKVKEHLQLAAEVYYDTEPEAVGTGISKDEYIKVAMKDNEWGGSLEASMLSKHLQTTIILWVVNSTEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRII
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Diversity of Ubiquitin and ISG15 Specificity among Nairoviruses' Viral Ovarian Tumor Domain Proteases.
pubmed doi rcsb
molecule tags Hydrolase/viral protein
source organism Homo sapiens
molecule keywords Polyubiquitin-C
total genus 43
structure length 157
sequence length 157
chains with identical sequence D
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2012-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF02338 OTU OTU-like cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.80 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4hxdB00
4BOZA 5JZEA 3C0RA 4HXDB 3PT2A 4BOQA 3PSEA 3PHWA 3TMPA 4BOUA 3PRPA 3PHUA 3ZNHA 4BOSA 3PHXA 4BOPA 3PRMA 3BY4A
chains in the Genus database with same CATH superfamily
1PBHA 3KWBX 2NQAA 4PP2E 3H6SA 2AGAA 4W5CA 5E6JA 1SNKA 4RKXA 3H7DA 2J7QA 3E1ZB 1GCBA 1NB3A 2DCAA 2DCCA 2WBFX 4OEMA 2AYNA 2OULA 1ATKA 4HXDB 2DCDA 3BB7A 3BCNA 1THEA 2R9MA 2CB5A 3GCBA 3QT4A 2G8JA 3BPMA 4CDCB 2BDLA 3F75A 3PNRA 3N3GA 3LXSA 5CVMA 2G6DA 4QRXA 2AIMA 3RVXA 2JRIA 4BOZA 3C9EA 1F2CA 2AUZA 2DC7A 2Y5BA 3AI8A 1Y4HA 4G54A 4YV8A 2HWKA 1KFUL 3PHWA 4MI7A 1VJVA 5A24A 3RVVA 1EWLA 2DZYA 4FJCA 5F02A 2R6NA 4BOSA 2NQIA 5FPWA 4K7CA 4CDFB 1U9VA 5JA7A 2XU3A 2XU1A 2IPPB 1KFXL 4IP3A 3HD3A 5EZSA 4BOQA 6PADA 3MORA 1NQCA 4DMYA 1QDQA 1U9QX 2JQGR 1STFE 5EF4A 1JQPA 2XU5A 3P5UA 2DJFB 2DJGB 1CV8A 4ZTBA 3BY4A 1AYVA 1FH0A 4R3DA 4QRVA 3MP2A 3H89A 1BQIA 2DC8A 4Q8HA 2HXZA 2R9OA 3OISA 1NB5A 5EZQA 1ITOA 2YJ2A 5CVNB 4P6EA 2YJCA 1UKFA 3PRMA 4XR7A 1POPA 4I05A 4P16A 4RY2A 3KWZA 1NLJA 1PPPA 3PRPA 2PREA 3O1GA 3I06A 4XUIA 2ATOA 4PI3A 3V6EA 4I04A 2P86A 3KW9A 4GUAA 2FQ9A 2E03A 1DF0A 4BS5A 2BU3A 2B1NA 2FTDA 3PBHA 2UZJA 3TNXA 1AYUA 5KO3A 5CHVA 3OF8A 5CHTA 3W31A 4BPVA 1MEGA 1GECE 2OP3A 4OELA 1ZIVA 2E01A 2AVWA 1O0EA 2PBHA 3WXGA 3RNVA 4CDDB 1F2BA 1KHQA 3HWNA 2G7YA 2JQFR 2CIOA 1YZBA 1CPJA 2ARYA 4QRGA 1F2AA 1CTEA 3BBAA 2FT2A 3S3RA 4FK5A 2NQGA 3PHUA 3U8EA 3IFUA 2FE8A 3CBJA 2YJ9A 4FIPA 4P6GA 2DOSA 3IEJA 2B1MA 1BY8A 1CQDA 3QSDA 3B79A 2FYEA 5EGWA 1YT7A 3PT2A 1ICFA 1CS8A 3ZUAA 2R9FA 2C0YA 3S3QA 3K24A 1MDWA 1EWMA 4OVZA 3TRKA 1PPNA 3K9MA 3KKUA 3D6SA 2FRAA 4I07A 4MSXA 2AYOA 2R9NA 1NPZA 4N8WA 1U9WA 2DC6A 2R9CA 2O6XA 4DMXA 1AECA 2AUXA 3CBKA 1TL9A 1DEUA 1QOLA 3N4CA 5PADA 1QMYA 2Z84A 3MHSA 1AU2A 3MJ5A 1PIPA 4W5BA 4IUMA 2F7DA 1GLOA 3E9SA 2BTWA 3P5VA 4WA6A 4A5UA 2HHNA 3O0UA 4YYSA 4PT5A 4YVAA 1PXVA 4D8BA 2Y6EA 1U9XA 1BGOA 3MTVA 3HHAA 1X9YA 1CJLA 3IHPA 4YYQA 4RNAA 1PADA 2GFOA 3N3KA 4MM3B 3MTNA 3ERVA 3KX1A 4BS6A 3RVWA 2GHUA 4CDEB 2FUDA 1AU3A 3TMPA 1AU4A 8PCHA 1YK8A 4REZA 1EWPA 2YJ8A 2XU4A 2VHFA 3O65A 2P7UA 1CSBB 1TU6A 2F1GA 3QJ3A 2NQDB 3B21A 1S4VA 1ME4A 1AU0A 4XZXA 2J7QC 3DF0A 2IBIA 3PHXA 4ZUXU 3IUTA 3BOWA 4RF1A 1NL6A 1MS6A 1VSNA 4X6IA 3NHEA 4BQVA 3BPFA 1BP4A 2FO5A 4W4UA 1PVJA 3BC3A 3PW3A 4MZSA 5CVOB 3WXEA 1AIMA 1K3BB 4D8EA 1M6DA 3KSEA 1Y08A 1EF7A 3IMAA 1CB5A 1EWOA 2ACTA 3OVZA 4N4ZA 1IWDA 1YVBA 4PADA 3PSEA 3H8BA 1GMYA 2OZ2A 3MHHA 3PDFA 2DCBA 3BWKA 2BDZA 1PE6A 4D8IA 1F29A 1ZCMA 4Q8GA 1KXRA 4PP1A 3W30A 4N79A 1A6RA 3P5WA 4BSQA 4YYWA 4X6HA 4BOPA 2P0RA 2FRQA 7PCKA 1YK7A 1XKGA 5JH3A 1YALA 1MIRA 2HH5A 3HHIA 3IOQA 3CH2X 2E00A 4OVZB 4OW0A 5J94A 1SP4B 1KHPA 4MZOA 3CH3X 4YYRA 1HUCB 2PNSA 3F5VA 3KFQA 5JZEA 4AXLA 1Q6KA 3USVA 3LFYA 3WXFA 2JTCA 4QH6A 3IV2A 1QXPA 1CVZA 2PADA 1PPDA 4YYVA 2HD5A 5K16A 4QBBA 1MEMA 2H7JA 2DC9A 4BOUA 3K8UA 2AS8A 4WURA 3OQCA 1PCIA 2G8EA 1MHWA 3C0RA 1DKIA 3OF9A 1TLOA 9PAPA 4M0WA 3H8CA 2E02A 3OVXA 3M99A 2BTWB 2YJBA 4CZWA 1ME3A 2DZZA 1PPOA 4RF0A 4HWYA 1U5IA 2AU1A 2VHSA 4AXMA 3V6CA 3I3TA 1AYWA 3P5XA 3ZNHA 4X6JA 4YYUA 4KLBA
chains in the Genus database with same CATH topology
3PSEA 1UKFA 5E6JA 2AGAA 3PRMA 4RKXA 2Z84A 4P16A 3MJ5A 3PRPA 2J7QA 4IUMA 4D8IA 3E9SA 3W30A 2BTWA 4GUAA 4A5UA 4HXDB 4PT5A 2BU3A 3BB7A 4D8BA 4BOPA 2UZJA 3MTVA 5KO3A 4RNAA 3W31A 4MM3B 4OVZB 4OW0A 3TMPA 2JRIA 3RNVA 4BOZA 5JZEA 4REZA 3O65A 2JTCA 1YZBA 2HWKA 4MI7A 3PHWA 3BBAA 3B21A 4BOUA 3PHUA 4BOSA 3IFUA 3OQCA 4WURA 2FE8A 3C0RA 1DKIA 4XZXA 2J7QC 4M0WA 2DOSA 2BTWB 4IP3A 5EZSA 4BOQA 3PHXA 3PT2A 4RF1A 4RF0A 4OVZA 3TRKA 4ZTBA 3BY4A 1PVJA 4R3DA 3MP2A 3ZNHA 4D8EA 5EZQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BOZ A;  5JZE A;  3C0R A;  4HXD B;  3PT2 A;  4BOQ A;  3PSE A;  3PHW A;  3TMP A;  4BOU A;  3PRP A;  3PHU A;  3ZNH A;  4BOS A;  3PHX A;  4BOP A;  3PRM A;  3BY4 A; 
#chains in the Genus database with same CATH topology
 1PBH A;  3KWB X;  2NQA A;  4PP2 E;  3H6S A;  2AGA A;  4W5C A;  5E6J A;  1SNK A;  4RKX A;  3H7D A;  2J7Q A;  3E1Z B;  1GCB A;  1NB3 A;  2DCA A;  2DCC A;  2WBF X;  4OEM A;  2AYN A;  2OUL A;  1ATK A;  4HXD B;  2DCD A;  3BB7 A;  3BCN A;  1THE A;  2R9M A;  2CB5 A;  3GCB A;  3QT4 A;  2G8J A;  3BPM A;  4CDC B;  2BDL A;  3F75 A;  3PNR A;  3N3G A;  3LXS A;  5CVM A;  2G6D A;  4QRX A;  2AIM A;  3RVX A;  2JRI A;  4BOZ A;  3C9E A;  1F2C A;  2AUZ A;  2DC7 A;  2Y5B A;  3AI8 A;  1Y4H A;  4G54 A;  4YV8 A;  2HWK A;  1KFU L;  3PHW A;  4MI7 A;  1VJV A;  5A24 A;  3RVV A;  1EWL A;  2DZY A;  4FJC A;  5F02 A;  2R6N A;  4BOS A;  2NQI A;  5FPW A;  4K7C A;  4CDF B;  1U9V A;  5JA7 A;  2XU3 A;  2XU1 A;  2IPP B;  1KFX L;  4IP3 A;  3HD3 A;  5EZS A;  4BOQ A;  6PAD A;  3MOR A;  1NQC A;  4DMY A;  1QDQ A;  1U9Q X;  2JQG R;  1STF E;  5EF4 A;  1JQP A;  2XU5 A;  3P5U A;  2DJF B;  2DJG B;  1CV8 A;  4ZTB A;  3BY4 A;  1AYV A;  1FH0 A;  4R3D A;  4QRV A;  3MP2 A;  3H89 A;  1BQI A;  2DC8 A;  4Q8H A;  2HXZ A;  2R9O A;  3OIS A;  1NB5 A;  5EZQ A;  1ITO A;  2YJ2 A;  5CVN B;  4P6E A;  2YJC A;  1UKF A;  3PRM A;  4XR7 A;  1POP A;  4I05 A;  4P16 A;  4RY2 A;  3KWZ A;  1NLJ A;  1PPP A;  3PRP A;  2PRE A;  3O1G A;  3I06 A;  4XUI A;  2ATO A;  4PI3 A;  3V6E A;  4I04 A;  2P86 A;  3KW9 A;  4GUA A;  2FQ9 A;  2E03 A;  1DF0 A;  4BS5 A;  2BU3 A;  2B1N A;  2FTD A;  3PBH A;  2UZJ A;  3TNX A;  1AYU A;  5KO3 A;  5CHV A;  3OF8 A;  5CHT A;  3W31 A;  4BPV A;  1MEG A;  1GEC E;  2OP3 A;  4OEL A;  1ZIV A;  2E01 A;  2AVW A;  1O0E A;  2PBH A;  3WXG A;  3RNV A;  4CDD B;  1F2B A;  1KHQ A;  3HWN A;  2G7Y A;  2JQF R;  2CIO A;  1YZB A;  1CPJ A;  2ARY A;  4QRG A;  1F2A A;  1CTE A;  3BBA A;  2FT2 A;  3S3R A;  4FK5 A;  2NQG A;  3PHU A;  3U8E A;  3IFU A;  2FE8 A;  3CBJ A;  2YJ9 A;  4FIP A;  4P6G A;  2DOS A;  3IEJ A;  2B1M A;  1BY8 A;  1CQD A;  3QSD A;  3B79 A;  2FYE A;  5EGW A;  1YT7 A;  3PT2 A;  1ICF A;  1CS8 A;  3ZUA A;  2R9F A;  2C0Y A;  3S3Q A;  3K24 A;  1MDW A;  1EWM A;  4OVZ A;  3TRK A;  1PPN A;  3K9M A;  3KKU A;  3D6S A;  2FRA A;  4I07 A;  4MSX A;  2AYO A;  2R9N A;  1NPZ A;  4N8W A;  1U9W A;  2DC6 A;  2R9C A;  2O6X A;  4DMX A;  1AEC A;  2AUX A;  3CBK A;  1TL9 A;  1DEU A;  1QOL A;  3N4C A;  5PAD A;  1QMY A;  2Z84 A;  3MHS A;  1AU2 A;  3MJ5 A;  1PIP A;  4W5B A;  4IUM A;  2F7D A;  1GLO A;  3E9S A;  2BTW A;  3P5V A;  4WA6 A;  4A5U A;  2HHN A;  3O0U A;  4YYS A;  4PT5 A;  4YVA A;  1PXV A;  4D8B A;  2Y6E A;  1U9X A;  1BGO A;  3MTV A;  3HHA A;  1X9Y A;  1CJL A;  3IHP A;  4YYQ A;  4RNA A;  1PAD A;  2GFO A;  3N3K A;  4MM3 B;  3MTN A;  3ERV A;  3KX1 A;  4BS6 A;  3RVW A;  2GHU A;  4CDE B;  2FUD A;  1AU3 A;  3TMP A;  1AU4 A;  8PCH A;  1YK8 A;  4REZ A;  1EWP A;  2YJ8 A;  2XU4 A;  2VHF A;  3O65 A;  2P7U A;  1CSB B;  1TU6 A;  2F1G A;  3QJ3 A;  2NQD B;  3B21 A;  1S4V A;  1ME4 A;  1AU0 A;  4XZX A;  2J7Q C;  3DF0 A;  2IBI A;  3PHX A;  4ZUX U;  3IUT A;  3BOW A;  4RF1 A;  1NL6 A;  1MS6 A;  1VSN A;  4X6I A;  3NHE A;  4BQV A;  3BPF A;  1BP4 A;  2FO5 A;  4W4U A;  1PVJ A;  3BC3 A;  3PW3 A;  4MZS A;  5CVO B;  3WXE A;  1AIM A;  1K3B B;  4D8E A;  1M6D A;  3KSE A;  1Y08 A;  1EF7 A;  3IMA A;  1CB5 A;  1EWO A;  2ACT A;  3OVZ A;  4N4Z A;  1IWD A;  1YVB A;  4PAD A;  3PSE A;  3H8B A;  1GMY A;  2OZ2 A;  3MHH A;  3PDF A;  2DCB A;  3BWK A;  2BDZ A;  1PE6 A;  4D8I A;  1F29 A;  1ZCM A;  4Q8G A;  1KXR A;  4PP1 A;  3W30 A;  4N79 A;  1A6R A;  3P5W A;  4BSQ A;  4YYW A;  4X6H A;  4BOP A;  2P0R A;  2FRQ A;  7PCK A;  1YK7 A;  1XKG A;  5JH3 A;  1YAL A;  1MIR A;  2HH5 A;  3HHI A;  3IOQ A;  3CH2 X;  2E00 A;  4OVZ B;  4OW0 A;  5J94 A;  1SP4 B;  1KHP A;  4MZO A;  3CH3 X;  4YYR A;  1HUC B;  2PNS A;  3F5V A;  3KFQ A;  5JZE A;  4AXL A;  1Q6K A;  3USV A;  3LFY A;  3WXF A;  2JTC A;  4QH6 A;  3IV2 A;  1QXP A;  1CVZ A;  2PAD A;  1PPD A;  4YYV A;  2HD5 A;  5K16 A;  4QBB A;  1MEM A;  2H7J A;  2DC9 A;  4BOU A;  3K8U A;  2AS8 A;  4WUR A;  3OQC A;  1PCI A;  2G8E A;  1MHW A;  3C0R A;  1DKI A;  3OF9 A;  1TLO A;  9PAP A;  4M0W A;  3H8C A;  2E02 A;  3OVX A;  3M99 A;  2BTW B;  2YJB A;  4CZW A;  1ME3 A;  2DZZ A;  1PPO A;  4RF0 A;  4HWY A;  1U5I A;  2AU1 A;  2VHS A;  4AXM A;  3V6C A;  3I3T A;  1AYW A;  3P5X A;  3ZNH A;  4X6J A;  4YYU A;  4KLB A; 
#chains in the Genus database with same CATH homology
 3PSE A;  1UKF A;  5E6J A;  2AGA A;  3PRM A;  4RKX A;  2Z84 A;  4P16 A;  3MJ5 A;  3PRP A;  2J7Q A;  4IUM A;  4D8I A;  3E9S A;  3W30 A;  2BTW A;  4GUA A;  4A5U A;  4HXD B;  4PT5 A;  2BU3 A;  3BB7 A;  4D8B A;  4BOP A;  2UZJ A;  3MTV A;  5KO3 A;  4RNA A;  3W31 A;  4MM3 B;  4OVZ B;  4OW0 A;  3TMP A;  2JRI A;  3RNV A;  4BOZ A;  5JZE A;  4REZ A;  3O65 A;  2JTC A;  1YZB A;  2HWK A;  4MI7 A;  3PHW A;  3BBA A;  3B21 A;  4BOU A;  3PHU A;  4BOS A;  3IFU A;  3OQC A;  4WUR A;  2FE8 A;  3C0R A;  1DKI A;  4XZX A;  2J7Q C;  4M0W A;  2DOS A;  2BTW B;  4IP3 A;  5EZS A;  4BOQ A;  3PHX A;  3PT2 A;  4RF1 A;  4RF0 A;  4OVZ A;  3TRK A;  4ZTB A;  3BY4 A;  1PVJ A;  4R3D A;  3MP2 A;  3ZNH A;  4D8E A;  5EZQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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