4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
molecule keywords Streptopain
molecule tags Hydrolase/hydrolase inhibitor
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
4D8EA 4RKXA 1PVJA 4D8BA 4D8IA 2UZJA 2JTCA 3BBAA 3BB7A 1DKIA
chains in the Genus database with same CATH superfamily
4OVZA 1FH0A 4FJCA 3BY4A 3D6SA 2XU1A 3F75A 2P7UA 1QMYA 3HWNA 1DKIA 3AI8A 1STFE 1MHWA 4K7CA 3PNRA 1A6RA 3OVXA 4CDCB 1GCBA 4BOQA 1QXPA 4RF1A 1MEMA 2BU3A 3WXGA 4OEMA 3DF0A 4I04A 2E01A 2R9FA 2WBFX 5K16A 4BOSA 3BOWA 3S3QA 3IUTA 2F7DA 4BS6A 3H8BA 2Y5BA 2R9OA 5CVNB 3MHSA 2C0YA 7PCKA 2JRIA 1TU6A 2DCDA 3PHXA 2R6NA 1MEGA 1CSBB 2DZYA 1AU2A 1F2AA 2ACTA 3WXEA 1BQIA 3GCBA 3KX1A 3E1ZB 3PW3A 3W30A 3I3TA 3PT2A 3PRPA 2G7YA 1TL9A 4YYQA 3QT4A 3KW9A 1PXVA 3KFQA 3PDFA 4WA6A 3O0UA 1KHPA 2G6DA 3H7DA 1F2CA 3PHWA 1NPZA 2R9CA 1PCIA 3KWBX 1NL6A 1Y08A 1CJLA 2CIOA 3PHUA 4AXLA 3MHHA 1JQPA 1U9WA 1YVBA 2BTWA 3K9MA 2FE8A 1CVZA 1F29A 1SNKA 2R9NA 3NHEA 1ZCMA 3V6CA 1AYWA 1PE6A 3IFUA 4A5UA 2R9MA 1AYVA 3E9SA 2YJ9A 2YJBA 4BOUA 1ICFA 4P6EA 3P5VA 5F02A 3O1GA 2FT2A 2DC7A 1CB5A 2DC8A 1PVJA 1CV8A 4QRVA 2AUZA 2YJ8A 1QDQA 4CDDB 1KFXL 3W31A 4YVAA 3KKUA 5JA7A 1MIRA 1VJVA 2FTDA 1AU3A 3M99A 1NLJA 2HH5A 4XUIA 4M0WA 5E6JA 1PPOA 2FO5A 1S4VA 4OELA 4QBBA 2DJGB 4XR7A 4CZWA 1THEA 1PIPA 5A24A 1U9QX 4BOPA 3BWKA 1NB5A 2DZZA 2NQAA 1PPPA 1M6DA 1YK7A 4MZOA 3F5VA 5PADA 4BPVA 3HHIA 4RNAA 2NQIA 1EWLA 4P16A 1O0EA 2ARYA 4GUAA 3IHPA 4N8WA 5CHTA 3MJ5A 3N3KA 3P5WA 3O65A 4IP3A 8PCHA 3BBAA 4FIPA 3BCNA 3RVWA 1YZBA 3USVA 1X9YA 1U9XA 4D8EA 1CQDA 3IV2A 2DOSA 1ATKA 3CBKA 3MTVA 2GHUA 5EZSA 1DEUA 2DJFB 1AECA 3U8EA 1CTEA 1NQCA 4G54A 4BOZA 4X6HA 4REZA 2AYNA 1U5IA 2PADA 1DF0A 3CH3X 4P6GA 2XU3A 4WURA 1ME3A 2Y6EA 4ZUXU 3ZUAA 2OP3A 3TMPA 2J7QA 4W5CA 3N4CA 1PPDA 2DCBA 3HHAA 2B1NA 4PI3A 4QRXA 3B21A 3QJ3A 4QH6A 2Z84A 4RF0A 2VHFA 1BGOA 3C9EA 2UZJA 4HXDB 4X6IA 4DMXA 2BDZA 3S3RA 1CS8A 4MZSA 4BSQA 3BPMA 3OQCA 2AS8A 5CHVA 4DMYA 3H6SA 2JQGR 3PBHA 1F2BA 1POPA 5KO3A 4YYSA 3PRMA 4QRGA 4HWYA 3P5XA 1AU0A 5EGWA 3BPFA 1Y4HA 1AYUA 3H8CA 1EWMA 1AIMA 2DCCA 3MP2A 1EWOA 2IPPB 2F1GA 2OZ2A 1XKGA 4BS5A 4PT5A 4BQVA 3ERVA 5J94A 2AIMA 4D8IA 3CH2X 4XZXA 3V6EA 1AU4A 3OF8A 1SP4B 5CVMA 3LFYA 4MI7A 3KSEA 3C0RA 3CBJA 2PBHA 3WXFA 1BY8A 1IWDA 4FK5A 5EF4A 3RVXA 1ME4A 3OF9A 2HXZA 1GLOA 2XU5A 5JH3A 4YV8A 1U9VA 1ZIVA 5FPWA 2FYEA 2AYOA 2AGAA 3LXSA 1TLOA 2E02A 2JTCA 3MORA 3P5UA 2H7JA 2O6XA 4MM3B 4Q8HA 1Q6KA 2PREA 3MTNA 4IUMA 2PNSA 4D8BA 1KFUL 4PP1A 4KLBA 3HD3A 1YT7A 4I05A 1K3BB 2E03A 1KHQA 2AVWA 3BB7A 2P86A 1YALA 3I06A 4RY2A 2XU4A 1GECE 2J7QC 4RKXA 2NQDB 2YJCA 4N79A 2BTWB 4PP2E 1MDWA 3RNVA 4W4UA 2G8JA 2GFOA 2BDLA 1PBHA 2JQFR 2DC6A 2G8EA 4R3DA 4AXMA 2CB5A 2B1MA 3PSEA 3OVZA 2FRAA 2HWKA 3OISA 2AU1A 1CPJA 1HUCB 4I07A 3IMAA 2ATOA 1NB3A 4Q8GA 3RVVA 2YJ2A 5JZEA 4YYVA 5EZQA 3K24A 1PPNA 1YK8A 3ZNHA 1KXRA 2E00A 3N3GA 3IEJA 4YYWA 1GMYA 5CVOB 1MS6A 3H89A 3TNXA 4OVZB 2VHSA 2HHNA 1VSNA 2HD5A 1ITOA 4W5BA 1EF7A 3KWZA 3IOQA 3TRKA 4X6JA 2DCAA 3K8UA 9PAPA 3QSDA 2FQ9A 4OW0A 2FUDA 4PADA 4ZTBA 4CDFB 4YYUA 2FRQA 4MSXA 6PADA 1QOLA 3BC3A 4N4ZA 1EWPA 4CDEB 2OULA 3B79A 1UKFA 2NQGA 2AUXA 2IBIA 1PADA 2P0RA 4YYRA 1BP4A 2DC9A
chains in the Genus database with same CATH topology
4BOUA 4MM3B 3TMPA 4IUMA 4D8BA 2J7QA 4OVZA 3BY4A 1PVJA 3BB7A 1DKIA 3B21A 2Z84A 4RF0A 3W31A 4BOQA 4RF1A 2BU3A 2J7QC 4RKXA 2UZJA 4HXDB 2BTWB 3RNVA 4M0WA 5E6JA 3OQCA 4BOSA 4R3DA 3PSEA 5KO3A 4BOPA 3PRMA 2HWKA 2JRIA 3PHXA 4RNAA 4P16A 5JZEA 5EZQA 3MP2A 4GUAA 3MJ5A 3ZNHA 4PT5A 3W30A 3O65A 4IP3A 4D8IA 3BBAA 4XZXA 1YZBA 3PT2A 3PRPA 4MI7A 4OVZB 4D8EA 3C0RA 2DOSA 3TRKA 3PHWA 3MTVA 5EZSA 4OW0A 4BOZA 3PHUA 4ZTBA 4REZA 2BTWA 2FE8A 4WURA 2AGAA 3IFUA 1UKFA 2JTCA 4A5UA 3E9SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8E A;  4RKX A;  1PVJ A;  4D8B A;  4D8I A;  2UZJ A;  2JTC A;  3BBA A;  3BB7 A;  1DKI A; 
#chains in the Genus database with same CATH topology
 4OVZ A;  1FH0 A;  4FJC A;  3BY4 A;  3D6S A;  2XU1 A;  3F75 A;  2P7U A;  1QMY A;  3HWN A;  1DKI A;  3AI8 A;  1STF E;  1MHW A;  4K7C A;  3PNR A;  1A6R A;  3OVX A;  4CDC B;  1GCB A;  4BOQ A;  1QXP A;  4RF1 A;  1MEM A;  2BU3 A;  3WXG A;  4OEM A;  3DF0 A;  4I04 A;  2E01 A;  2R9F A;  2WBF X;  5K16 A;  4BOS A;  3BOW A;  3S3Q A;  3IUT A;  2F7D A;  4BS6 A;  3H8B A;  2Y5B A;  2R9O A;  5CVN B;  3MHS A;  2C0Y A;  7PCK A;  2JRI A;  1TU6 A;  2DCD A;  3PHX A;  2R6N A;  1MEG A;  1CSB B;  2DZY A;  1AU2 A;  1F2A A;  2ACT A;  3WXE A;  1BQI A;  3GCB A;  3KX1 A;  3E1Z B;  3PW3 A;  3W30 A;  3I3T A;  3PT2 A;  3PRP A;  2G7Y A;  1TL9 A;  4YYQ A;  3QT4 A;  3KW9 A;  1PXV A;  3KFQ A;  3PDF A;  4WA6 A;  3O0U A;  1KHP A;  2G6D A;  3H7D A;  1F2C A;  3PHW A;  1NPZ A;  2R9C A;  1PCI A;  3KWB X;  1NL6 A;  1Y08 A;  1CJL A;  2CIO A;  3PHU A;  4AXL A;  3MHH A;  1JQP A;  1U9W A;  1YVB A;  2BTW A;  3K9M A;  2FE8 A;  1CVZ A;  1F29 A;  1SNK A;  2R9N A;  3NHE A;  1ZCM A;  3V6C A;  1AYW A;  1PE6 A;  3IFU A;  4A5U A;  2R9M A;  1AYV A;  3E9S A;  2YJ9 A;  2YJB A;  4BOU A;  1ICF A;  4P6E A;  3P5V A;  5F02 A;  3O1G A;  2FT2 A;  2DC7 A;  1CB5 A;  2DC8 A;  1PVJ A;  1CV8 A;  4QRV A;  2AUZ A;  2YJ8 A;  1QDQ A;  4CDD B;  1KFX L;  3W31 A;  4YVA A;  3KKU A;  5JA7 A;  1MIR A;  1VJV A;  2FTD A;  1AU3 A;  3M99 A;  1NLJ A;  2HH5 A;  4XUI A;  4M0W A;  5E6J A;  1PPO A;  2FO5 A;  1S4V A;  4OEL A;  4QBB A;  2DJG B;  4XR7 A;  4CZW A;  1THE A;  1PIP A;  5A24 A;  1U9Q X;  4BOP A;  3BWK A;  1NB5 A;  2DZZ A;  2NQA A;  1PPP A;  1M6D A;  1YK7 A;  4MZO A;  3F5V A;  5PAD A;  4BPV A;  3HHI A;  4RNA A;  2NQI A;  1EWL A;  4P16 A;  1O0E A;  2ARY A;  4GUA A;  3IHP A;  4N8W A;  5CHT A;  3MJ5 A;  3N3K A;  3P5W A;  3O65 A;  4IP3 A;  8PCH A;  3BBA A;  4FIP A;  3BCN A;  3RVW A;  1YZB A;  3USV A;  1X9Y A;  1U9X A;  4D8E A;  1CQD A;  3IV2 A;  2DOS A;  1ATK A;  3CBK A;  3MTV A;  2GHU A;  5EZS A;  1DEU A;  2DJF B;  1AEC A;  3U8E A;  1CTE A;  1NQC A;  4G54 A;  4BOZ A;  4X6H A;  4REZ A;  2AYN A;  1U5I A;  2PAD A;  1DF0 A;  3CH3 X;  4P6G A;  2XU3 A;  4WUR A;  1ME3 A;  2Y6E A;  4ZUX U;  3ZUA A;  2OP3 A;  3TMP A;  2J7Q A;  4W5C A;  3N4C A;  1PPD A;  2DCB A;  3HHA A;  2B1N A;  4PI3 A;  4QRX A;  3B21 A;  3QJ3 A;  4QH6 A;  2Z84 A;  4RF0 A;  2VHF A;  1BGO A;  3C9E A;  2UZJ A;  4HXD B;  4X6I A;  4DMX A;  2BDZ A;  3S3R A;  1CS8 A;  4MZS A;  4BSQ A;  3BPM A;  3OQC A;  2AS8 A;  5CHV A;  4DMY A;  3H6S A;  2JQG R;  3PBH A;  1F2B A;  1POP A;  5KO3 A;  4YYS A;  3PRM A;  4QRG A;  4HWY A;  3P5X A;  1AU0 A;  5EGW A;  3BPF A;  1Y4H A;  1AYU A;  3H8C A;  1EWM A;  1AIM A;  2DCC A;  3MP2 A;  1EWO A;  2IPP B;  2F1G A;  2OZ2 A;  1XKG A;  4BS5 A;  4PT5 A;  4BQV A;  3ERV A;  5J94 A;  2AIM A;  4D8I A;  3CH2 X;  4XZX A;  3V6E A;  1AU4 A;  3OF8 A;  1SP4 B;  5CVM A;  3LFY A;  4MI7 A;  3KSE A;  3C0R A;  3CBJ A;  2PBH A;  3WXF A;  1BY8 A;  1IWD A;  4FK5 A;  5EF4 A;  3RVX A;  1ME4 A;  3OF9 A;  2HXZ A;  1GLO A;  2XU5 A;  5JH3 A;  4YV8 A;  1U9V A;  1ZIV A;  5FPW A;  2FYE A;  2AYO A;  2AGA A;  3LXS A;  1TLO A;  2E02 A;  2JTC A;  3MOR A;  3P5U A;  2H7J A;  2O6X A;  4MM3 B;  4Q8H A;  1Q6K A;  2PRE A;  3MTN A;  4IUM A;  2PNS A;  4D8B A;  1KFU L;  4PP1 A;  4KLB A;  3HD3 A;  1YT7 A;  4I05 A;  1K3B B;  2E03 A;  1KHQ A;  2AVW A;  3BB7 A;  2P86 A;  1YAL A;  3I06 A;  4RY2 A;  2XU4 A;  1GEC E;  2J7Q C;  4RKX A;  2NQD B;  2YJC A;  4N79 A;  2BTW B;  4PP2 E;  1MDW A;  3RNV A;  4W4U A;  2G8J A;  2GFO A;  2BDL A;  1PBH A;  2JQF R;  2DC6 A;  2G8E A;  4R3D A;  4AXM A;  2CB5 A;  2B1M A;  3PSE A;  3OVZ A;  2FRA A;  2HWK A;  3OIS A;  2AU1 A;  1CPJ A;  1HUC B;  4I07 A;  3IMA A;  2ATO A;  1NB3 A;  4Q8G A;  3RVV A;  2YJ2 A;  5JZE A;  4YYV A;  5EZQ A;  3K24 A;  1PPN A;  1YK8 A;  3ZNH A;  1KXR A;  2E00 A;  3N3G A;  3IEJ A;  4YYW A;  1GMY A;  5CVO B;  1MS6 A;  3H89 A;  3TNX A;  4OVZ B;  2VHS A;  2HHN A;  1VSN A;  2HD5 A;  1ITO A;  4W5B A;  1EF7 A;  3KWZ A;  3IOQ A;  3TRK A;  4X6J A;  2DCA A;  3K8U A;  9PAP A;  3QSD A;  2FQ9 A;  4OW0 A;  2FUD A;  4PAD A;  4ZTB A;  4CDF B;  4YYU A;  2FRQ A;  4MSX A;  6PAD A;  1QOL A;  3BC3 A;  4N4Z A;  1EWP A;  4CDE B;  2OUL A;  3B79 A;  1UKF A;  2NQG A;  2AUX A;  2IBI A;  1PAD A;  2P0R A;  4YYR A;  1BP4 A;  2DC9 A; 
#chains in the Genus database with same CATH homology
 4BOU A;  4MM3 B;  3TMP A;  4IUM A;  4D8B A;  2J7Q A;  4OVZ A;  3BY4 A;  1PVJ A;  3BB7 A;  1DKI A;  3B21 A;  2Z84 A;  4RF0 A;  3W31 A;  4BOQ A;  4RF1 A;  2BU3 A;  2J7Q C;  4RKX A;  2UZJ A;  4HXD B;  2BTW B;  3RNV A;  4M0W A;  5E6J A;  3OQC A;  4BOS A;  4R3D A;  3PSE A;  5KO3 A;  4BOP A;  3PRM A;  2HWK A;  2JRI A;  3PHX A;  4RNA A;  4P16 A;  5JZE A;  5EZQ A;  3MP2 A;  4GUA A;  3MJ5 A;  3ZNH A;  4PT5 A;  3W30 A;  3O65 A;  4IP3 A;  4D8I A;  3BBA A;  4XZX A;  1YZB A;  3PT2 A;  3PRP A;  4MI7 A;  4OVZ B;  4D8E A;  3C0R A;  2DOS A;  3TRK A;  3PHW A;  3MTV A;  5EZS A;  4OW0 A;  4BOZ A;  3PHU A;  4ZTB A;  4REZ A;  2BTW A;  2FE8 A;  4WUR A;  2AGA A;  3IFU A;  1UKF A;  2JTC A;  4A5U A;  3E9S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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