4RKXA

Identification and characterization of a small molecule inhibitor of s. pyogenes speb.
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Streptopain
publication title Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4rkxA00
3BB7A 4RKXA 2UZJA 4D8EA 1DKIA 3BBAA 4D8IA 1PVJA 2JTCA 4D8BA
chains in the Genus database with same CATH superfamily
2HD5A 2XU4A 5CVOB 1F2AA 4MZOA 3I3TA 4FJCA 3I06A 1KHPA 1NL6A 1NLJA 2DC7A 2B1MA 1PCIA 3W30A 1AU2A 1KFUL 3BBAA 1GCBA 2IBIA 2PREA 3IHPA 2Z84A 1F29A 3PRMA 4P6EA 3RNVA 4QH6A 9PAPA 2AYNA 4BOUA 5CVMA 1ITOA 2R9FA 1POPA 2F1GA 2J7QC 4AXLA 3IFUA 3PBHA 1ZCMA 1U9QX 2AU1A 2R9CA 3O0UA 4N8WA 4YV8A 2BTWB 3WXGA 3S3RA 2G8JA 4CDCB 1YALA 1SNKA 2HH5A 2P7UA 5CVNB 3H7DA 1QDQA 1AECA 4MI7A 7PCKA 1QOLA 4AXMA 4MM3B 1CTEA 3BCNA 5F02A 1PIPA 3F5VA 3H89A 3W31A 2PBHA 3IMAA 3H8BA 1MDWA 5E6JA 2DJFB 2Y6EA 3IV2A 1QXPA 3QSDA 3OVXA 1PPNA 4BPVA 2HWKA 4RF0A 1NPZA 1Y08A 4BOZA 2DJGB 4REZA 1PXVA 2YJBA 4CDFB 4HWYA 3H6SA 4PI3A 3KKUA 3U8EA 2AS8A 1Q6KA 3BY4A 3C0RA 2AGAA 1BQIA 3PHUA 1TU6A 2AYOA 3PHWA 3TNXA 3CBJA 2FRQA 4FK5A 1MEGA 4YYVA 3E9SA 1AU3A 4W4UA 1YK8A 2OULA 2VHFA 2GHUA 4N79A 3BC3A 2DZZA 4QRVA 1AU4A 1YT7A 1PE6A 1F2BA 3HWNA 3LXSA 1AIMA 2UZJA 1UKFA 2YJ2A 1CV8A 2AIMA 2AUZA 3H8CA 2P86A 2FT2A 4G54A 3PDFA 2JTCA 2NQGA 2P0RA 3M99A 3N4CA 4BOQA 3KX1A 2OZ2A 3BOWA 4KLBA 3ERVA 4OELA 3F75A 2HXZA 1AYVA 1CQDA 3S3QA 4BS6A 1QMYA 3IEJA 3CH2X 4BS5A 2JRIA 3ZNHA 4ZUXU 1ME3A 1ICFA 3V6EA 3KWZA 3MTNA 4OEMA 4I04A 1NB3A 4RNAA 3MTVA 2XU5A 2O6XA 4N4ZA 4DMXA 2JQFR 1F2CA 3P5VA 1O0EA 1DKIA 2PADA 1KXRA 4BQVA 3MORA 8PCHA 3KSEA 2AUXA 3WXEA 3OVZA 3BPMA 5JZEA 2NQDB 1GLOA 4BOSA 2C0YA 2E00A 3OQCA 4PP2E 4PADA 1EWPA 4OVZB 2IPPB 3IUTA 3QJ3A 2CIOA 3TMPA 1DEUA 4Q8GA 1BP4A 1CB5A 4IUMA 4YVAA 3PNRA 2ACTA 3DF0A 3USVA 1PPDA 5PADA 1EF7A 1CPJA 1EWMA 3MHHA 4HXDB 3RVWA 1KHQA 2FRAA 2E03A 1X9YA 3BWKA 6PADA 4MSXA 4X6HA 4MZSA 3CBKA 1ME4A 3KWBX 4I07A 4YYSA 4YYUA 2VHSA 3HHAA 5A24A 2BDLA 1GECE 2NQIA 4D8BA 4OW0A 4DMYA 2ATOA 4CZWA 3QT4A 4OVZA 1PPOA 3B21A 4QRXA 4X6IA 1Y4HA 1TLOA 4W5CA 3K9MA 1YK7A 4K7CA 1MEMA 3PSEA 2DZYA 5JA7A 2FYEA 4RKXA 2BTWA 1A6RA 2J7QA 2F7DA 1K3BB 3IOQA 2B1NA 4QRGA 5EZSA 2G6DA 2DOSA 2XU3A 2PNSA 4IP3A 4R3DA 3P5XA 4I05A 2DCDA 3LFYA 5K16A 1KFXL 3E1ZB 1EWOA 5FPWA 2FO5A 5EF4A 3HD3A 3BPFA 1CVZA 1U9XA 3P5WA 4D8IA 3PRPA 3K8UA 3MHSA 4P16A 2YJCA 2R6NA 3C9EA 4QBBA 3AI8A 3KW9A 3HHIA 1PADA 3D6SA 1DF0A 1CS8A 4RF1A 1SP4B 3B79A 2H7JA 3K24A 1IWDA 1U9WA 3OF9A 2DC8A 3CH3X 4YYRA 2DCCA 3WXFA 1AU0A 1CSBB 3N3KA 2FQ9A 2R9NA 3MJ5A 3MP2A 4ZTBA 2G8EA 4GUAA 4D8EA 2FUDA 1PBHA 2DCBA 4CDDB 2FE8A 1GMYA 2BU3A 1U9VA 3V6CA 5KO3A 1ATKA 1YVBA 4M0WA 1BGOA 2R9MA 2ARYA 4P6GA 3ZUAA 4CDEB 2OP3A 1HUCB 1M6DA 5CHTA 4YYWA 1FH0A 1VSNA 1TL9A 2BDZA 4PT5A 5EGWA 4FIPA 1MS6A 4XUIA 2WBFX 3RVVA 1BY8A 3O65A 5CHVA 4BOPA 4XR7A 1ZIVA 3RVXA 2R9OA 3O1GA 2G7YA 2CB5A 2JQGR 2HHNA 5EZQA 2GFOA 3NHEA 4XZXA 1U5IA 2AVWA 3OISA 1STFE 2YJ9A 4Q8HA 1THEA 3PHXA 5JH3A 1PVJA 1VJVA 1YZBA 2XU1A 5J94A 1CJLA 2DC9A 1XKGA 1JQPA 1MHWA 4YYQA 3TRKA 4X6JA 1MIRA 4W5BA 4A5UA 2YJ8A 4BSQA 1NQCA 2NQAA 4WA6A 2DCAA 2Y5BA 3GCBA 2DC6A 3PT2A 3KFQA 2E02A 1PPPA 3N3GA 3BB7A 3P5UA 1AYWA 1S4VA 3OF8A 4WURA 2FTDA 4PP1A 4RY2A 1NB5A 3PW3A 1AYUA 2E01A 1EWLA
chains in the Genus database with same CATH topology
2UZJA 1UKFA 4D8BA 4OW0A 2JTCA 4OVZA 3B21A 3W30A 4BOQA 3BBAA 4PT5A 2Z84A 3PSEA 3PRMA 3RNVA 4RKXA 2BTWA 2J7QA 2JRIA 3O65A 4BOUA 4BOPA 3ZNHA 5EZSA 4RNAA 3MTVA 2DOSA 2J7QC 3IFUA 4IP3A 4R3DA 1DKIA 5EZQA 2BTWB 4XZXA 5JZEA 4D8IA 3PRPA 4BOSA 3PHXA 3OQCA 4MI7A 4P16A 4MM3B 4OVZB 1PVJA 3W31A 3TMPA 1YZBA 5E6JA 4IUMA 2HWKA 4RF0A 4BOZA 3TRKA 4REZA 4RF1A 4A5UA 4HXDB 3BY4A 3C0RA 2AGAA 3PHUA 3PT2A 3PHWA 3MP2A 3MJ5A 4ZTBA 3BB7A 4GUAA 3E9SA 4D8EA 2FE8A 4WURA 2BU3A 5KO3A 4M0WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BB7 A;  4RKX A;  2UZJ A;  4D8E A;  1DKI A;  3BBA A;  4D8I A;  1PVJ A;  2JTC A;  4D8B A; 
#chains in the Genus database with same CATH topology
 2HD5 A;  2XU4 A;  5CVO B;  1F2A A;  4MZO A;  3I3T A;  4FJC A;  3I06 A;  1KHP A;  1NL6 A;  1NLJ A;  2DC7 A;  2B1M A;  1PCI A;  3W30 A;  1AU2 A;  1KFU L;  3BBA A;  1GCB A;  2IBI A;  2PRE A;  3IHP A;  2Z84 A;  1F29 A;  3PRM A;  4P6E A;  3RNV A;  4QH6 A;  9PAP A;  2AYN A;  4BOU A;  5CVM A;  1ITO A;  2R9F A;  1POP A;  2F1G A;  2J7Q C;  4AXL A;  3IFU A;  3PBH A;  1ZCM A;  1U9Q X;  2AU1 A;  2R9C A;  3O0U A;  4N8W A;  4YV8 A;  2BTW B;  3WXG A;  3S3R A;  2G8J A;  4CDC B;  1YAL A;  1SNK A;  2HH5 A;  2P7U A;  5CVN B;  3H7D A;  1QDQ A;  1AEC A;  4MI7 A;  7PCK A;  1QOL A;  4AXM A;  4MM3 B;  1CTE A;  3BCN A;  5F02 A;  1PIP A;  3F5V A;  3H89 A;  3W31 A;  2PBH A;  3IMA A;  3H8B A;  1MDW A;  5E6J A;  2DJF B;  2Y6E A;  3IV2 A;  1QXP A;  3QSD A;  3OVX A;  1PPN A;  4BPV A;  2HWK A;  4RF0 A;  1NPZ A;  1Y08 A;  4BOZ A;  2DJG B;  4REZ A;  1PXV A;  2YJB A;  4CDF B;  4HWY A;  3H6S A;  4PI3 A;  3KKU A;  3U8E A;  2AS8 A;  1Q6K A;  3BY4 A;  3C0R A;  2AGA A;  1BQI A;  3PHU A;  1TU6 A;  2AYO A;  3PHW A;  3TNX A;  3CBJ A;  2FRQ A;  4FK5 A;  1MEG A;  4YYV A;  3E9S A;  1AU3 A;  4W4U A;  1YK8 A;  2OUL A;  2VHF A;  2GHU A;  4N79 A;  3BC3 A;  2DZZ A;  4QRV A;  1AU4 A;  1YT7 A;  1PE6 A;  1F2B A;  3HWN A;  3LXS A;  1AIM A;  2UZJ A;  1UKF A;  2YJ2 A;  1CV8 A;  2AIM A;  2AUZ A;  3H8C A;  2P86 A;  2FT2 A;  4G54 A;  3PDF A;  2JTC A;  2NQG A;  2P0R A;  3M99 A;  3N4C A;  4BOQ A;  3KX1 A;  2OZ2 A;  3BOW A;  4KLB A;  3ERV A;  4OEL A;  3F75 A;  2HXZ A;  1AYV A;  1CQD A;  3S3Q A;  4BS6 A;  1QMY A;  3IEJ A;  3CH2 X;  4BS5 A;  2JRI A;  3ZNH A;  4ZUX U;  1ME3 A;  1ICF A;  3V6E A;  3KWZ A;  3MTN A;  4OEM A;  4I04 A;  1NB3 A;  4RNA A;  3MTV A;  2XU5 A;  2O6X A;  4N4Z A;  4DMX A;  2JQF R;  1F2C A;  3P5V A;  1O0E A;  1DKI A;  2PAD A;  1KXR A;  4BQV A;  3MOR A;  8PCH A;  3KSE A;  2AUX A;  3WXE A;  3OVZ A;  3BPM A;  5JZE A;  2NQD B;  1GLO A;  4BOS A;  2C0Y A;  2E00 A;  3OQC A;  4PP2 E;  4PAD A;  1EWP A;  4OVZ B;  2IPP B;  3IUT A;  3QJ3 A;  2CIO A;  3TMP A;  1DEU A;  4Q8G A;  1BP4 A;  1CB5 A;  4IUM A;  4YVA A;  3PNR A;  2ACT A;  3DF0 A;  3USV A;  1PPD A;  5PAD A;  1EF7 A;  1CPJ A;  1EWM A;  3MHH A;  4HXD B;  3RVW A;  1KHQ A;  2FRA A;  2E03 A;  1X9Y A;  3BWK A;  6PAD A;  4MSX A;  4X6H A;  4MZS A;  3CBK A;  1ME4 A;  3KWB X;  4I07 A;  4YYS A;  4YYU A;  2VHS A;  3HHA A;  5A24 A;  2BDL A;  1GEC E;  2NQI A;  4D8B A;  4OW0 A;  4DMY A;  2ATO A;  4CZW A;  3QT4 A;  4OVZ A;  1PPO A;  3B21 A;  4QRX A;  4X6I A;  1Y4H A;  1TLO A;  4W5C A;  3K9M A;  1YK7 A;  4K7C A;  1MEM A;  3PSE A;  2DZY A;  5JA7 A;  2FYE A;  4RKX A;  2BTW A;  1A6R A;  2J7Q A;  2F7D A;  1K3B B;  3IOQ A;  2B1N A;  4QRG A;  5EZS A;  2G6D A;  2DOS A;  2XU3 A;  2PNS A;  4IP3 A;  4R3D A;  3P5X A;  4I05 A;  2DCD A;  3LFY A;  5K16 A;  1KFX L;  3E1Z B;  1EWO A;  5FPW A;  2FO5 A;  5EF4 A;  3HD3 A;  3BPF A;  1CVZ A;  1U9X A;  3P5W A;  4D8I A;  3PRP A;  3K8U A;  3MHS A;  4P16 A;  2YJC A;  2R6N A;  3C9E A;  4QBB A;  3AI8 A;  3KW9 A;  3HHI A;  1PAD A;  3D6S A;  1DF0 A;  1CS8 A;  4RF1 A;  1SP4 B;  3B79 A;  2H7J A;  3K24 A;  1IWD A;  1U9W A;  3OF9 A;  2DC8 A;  3CH3 X;  4YYR A;  2DCC A;  3WXF A;  1AU0 A;  1CSB B;  3N3K A;  2FQ9 A;  2R9N A;  3MJ5 A;  3MP2 A;  4ZTB A;  2G8E A;  4GUA A;  4D8E A;  2FUD A;  1PBH A;  2DCB A;  4CDD B;  2FE8 A;  1GMY A;  2BU3 A;  1U9V A;  3V6C A;  5KO3 A;  1ATK A;  1YVB A;  4M0W A;  1BGO A;  2R9M A;  2ARY A;  4P6G A;  3ZUA A;  4CDE B;  2OP3 A;  1HUC B;  1M6D A;  5CHT A;  4YYW A;  1FH0 A;  1VSN A;  1TL9 A;  2BDZ A;  4PT5 A;  5EGW A;  4FIP A;  1MS6 A;  4XUI A;  2WBF X;  3RVV A;  1BY8 A;  3O65 A;  5CHV A;  4BOP A;  4XR7 A;  1ZIV A;  3RVX A;  2R9O A;  3O1G A;  2G7Y A;  2CB5 A;  2JQG R;  2HHN A;  5EZQ A;  2GFO A;  3NHE A;  4XZX A;  1U5I A;  2AVW A;  3OIS A;  1STF E;  2YJ9 A;  4Q8H A;  1THE A;  3PHX A;  5JH3 A;  1PVJ A;  1VJV A;  1YZB A;  2XU1 A;  5J94 A;  1CJL A;  2DC9 A;  1XKG A;  1JQP A;  1MHW A;  4YYQ A;  3TRK A;  4X6J A;  1MIR A;  4W5B A;  4A5U A;  2YJ8 A;  4BSQ A;  1NQC A;  2NQA A;  4WA6 A;  2DCA A;  2Y5B A;  3GCB A;  2DC6 A;  3PT2 A;  3KFQ A;  2E02 A;  1PPP A;  3N3G A;  3BB7 A;  3P5U A;  1AYW A;  1S4V A;  3OF8 A;  4WUR A;  2FTD A;  4PP1 A;  4RY2 A;  1NB5 A;  3PW3 A;  1AYU A;  2E01 A;  1EWL A; 
#chains in the Genus database with same CATH homology
 2UZJ A;  1UKF A;  4D8B A;  4OW0 A;  2JTC A;  4OVZ A;  3B21 A;  3W30 A;  4BOQ A;  3BBA A;  4PT5 A;  2Z84 A;  3PSE A;  3PRM A;  3RNV A;  4RKX A;  2BTW A;  2J7Q A;  2JRI A;  3O65 A;  4BOU A;  4BOP A;  3ZNH A;  5EZS A;  4RNA A;  3MTV A;  2DOS A;  2J7Q C;  3IFU A;  4IP3 A;  4R3D A;  1DKI A;  5EZQ A;  2BTW B;  4XZX A;  5JZE A;  4D8I A;  3PRP A;  4BOS A;  3PHX A;  3OQC A;  4MI7 A;  4P16 A;  4MM3 B;  4OVZ B;  1PVJ A;  3W31 A;  3TMP A;  1YZB A;  5E6J A;  4IUM A;  2HWK A;  4RF0 A;  4BOZ A;  3TRK A;  4REZ A;  4RF1 A;  4A5U A;  4HXD B;  3BY4 A;  3C0R A;  2AGA A;  3PHU A;  3PT2 A;  3PHW A;  3MP2 A;  3MJ5 A;  4ZTB A;  3BB7 A;  4GUA A;  3E9S A;  4D8E A;  2FE8 A;  4WUR A;  2BU3 A;  5KO3 A;  4M0W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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