1S20A

A novel nad binding protein revealed by the crystal structure of e. coli 2,3-diketogulonate reductase (yiak) northeast structural genomics consortium target er82
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
334
structure length
334
Chain Sequence
MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQALLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Hypothetical oxidoreductase yiaK
total genus 98
structure length 334
sequence length 334
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.1.1.130: 3-dehydro-L-gulonate 2-dehydrogenase.
pdb deposition date 2004-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1s20A01
3.30.60.50 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Hypothetical oxidoreductase yiak; domain 3 1s20A03
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1s20A02
4FJSA 1Z2IA 1NXUA 2CWFA 2X06A 3UOEA 1WTJA 4FJUA 3I0PA 2CWHA 4H8AA 1X0AA 1V9NA 1S20A 1VBIA 2G8YA 1XRHA
chains in the Genus database with same CATH superfamily
1J5KA 1Y1BA 4OX9H 4DR7H 4JI2H 2NU4I 3VE5A 2Z0SA 3T1HH 2DGRA 1DTJA 1Y8FA 1PQXA 1IBLH 4K0KH 3CXLA 4JI1H 1CT4I 2CPQA 1S03G 5EX3A 3OXGA 2A20A 1TURA 2N71A 2PT7G 5HI7A 1TBOA 1X9ZA 1UHAA 2JVZA 1P9GA 1ODHA 1XRHA 4DUZH 2ELIA 2P6AC 1H0ZA 1XX6A 2RIJA 2RC4A 1CT2I 1BUSA 3FC3A 1IY6A 3UEJA 5JEAG 2ZQEA 1J4WA 1V1IA 4B3MH 4DR6H 2QQCA 2DKVA 2JXDA 1SGYI 2LB7A 4MPIA 1TUSA 5E3RA 1HPTA 4DV1H 3QD7X 2SGQI 2VQFH 2VRWB 3L7ZC 2UUCH 2QQDA 2KMRA 2JA1A 3QTLD 2NU2I 1XMOH 3TO9A 4E9JA 1CT0I 1Z7KB 2E5LH 1CE3A 2E3UA 2L7XA 2FNFX 1TBNA 2SGFI 1Q9BA 2CTMA 4FJUA 5FUWA 2LTLA 2LF0A 1LR9A 1IBKH 2N1AB 2DB6A 4DR2H 2E5RA 4OO1G 1LR8A 4B3RH 1WGTA 4B6DA 4JI6H 1MT1A 5FUVA 2JEAI 1WTJA 4DV3H 1AN1I 3J80W 2X52A 3SGBI 4JCVE 2B8TA 2UVOA 4B3TH 5E3PA 2UXCH 2HH2A 2ORVA 1ZZKA 1MSZA 3NCVA 3RF2A 5FLXW 2YUUA 4JI7H 4DV7H 1N32H 5BR8H 4B8CD 1CHOI 2KMPA 1EC6A 1SGEI 1ULNA 3OSSD 2OZUA 4LFAH 3JAMW 4LF9H 1FJGH 2FFMA 1XA6A 1ZTGA 1TBQR 2M8WA 1AN7A 2JZMA 1OMUA 4DV2H 2GIVA 1F0XA 3MEKA 3KDGA 4DV6H 2AXYA 1I94H 2V53A 1N34H 5IT9W 4GKJH 1X4SA 1HNWH 1TUAA 1PTQA 1VBIA 5LMUH 2W0TA 1UVGA 2N52A 2A1SA 3KDKA 4AMLA 2JA9A 1SGRI 1SGNI 4HGUA 4JVHA 2PY9A 1NXUA 1DS2I 4E1PA 1ULKA 2ANNA 2JEBI 2BUSA 4JVYA 2Y0MA 4DR5H 3E2IA 3VDPA 4UXHA 4X64H 3TOBA 1MJAA 4LF8H 1X74A 2F3CI 1OVOA 1KBFA 4NXNH 2DIPA 5FUYA 4A24A 1UVFA 4LFBH 5HQ8A 4LF4H 2J9RA 3OXLA 2KCXA 2OD1A 1MJBA 4GI3C 2LRRA 1IW4A 3UGLA 4OD6A 2WGCA 1LR7A 4AM3A 4NXMH 3OXFA 1HNZH 4H8AA 2QQ0A 5J8CA 2ENZA 4JI0H 2CWFA 4OCHA 4YY3H 3I0PA 2OPVA 2QNDA 2UU9H 2JW6A 2ROWA 1W3SA 2YQPA 4UXIA 1FY7A 1TBRR 2N17A 3V69A 4L9MA 1XNRH 3VDUA 2XRCA 3R5CA 2K9HA 4LF7H 2CTFA 1VIHA 1R79A 5CCLA 4PDBA 2HH3A 1CGJI 1X4MA 3EZJA 1IY5A 3HH2C 1X0AA 2NU0I 3E59A 3UFFA 2VQEH 2UUBH 2LTMA 5DT9A 1J5EH 2V1CC 2PQUA 2WVJA 3UGDA 3GABA 2VKCA 3QWPA 4X65H 4B8TA 4UXJA 2GKVA 4IFDG 1YU6C 1HR0H 2ORWA 4FKDA 2M6QA 4JI5H 3FSXA 5K36G 1XNQH 1TIHA 2QQEA 2PQ8A 4LFCH 3AEVB 4JI8H 1TOTA 5J8FA 4QMFB 2NN6G 4G08A 3GKUA 2LEOA 1PTRA 3KY9A 3OL0A 1K1GA 5EX0A 1SGPI 1SGDI 4NZRM 4DV5H 4LF5H 4DNCA 3UOEA 2OPUA 1KBEA 4DR4H 1HDLA 2D9IA 1WE8A 4KHPH 1ULMA 1I6UA 2ZM6H 1S20A 2CTLA 4AIMA 1BMOA 4DV4H 3FSYA 2FMRA 3SGQI 3OETA 2L8EA 9WGAA 1CGII 7WGAA 2UUAH 2GKRI 2X3TA 1V1HA 1OMTA 5DAEA 4JI4H 4X62H 4YHHH 2WCYA 3VKEA 2YQRA 2OVOA 4JYAH 2G8YA 1FARA 3TO7A 4EC5A 2ODDA 3QAHA 1VIGA 2CTKA 1ZZIA 1SEIA 1IBMH 1FYBA 1KMAA 4WP4A 2LUYA 1HNXH 2F4VH 3U1KA 2ERWA 4E1RA 4DUYH 4BA1I 4AQYH 1P9ZA 3T1YH 1DT4A 4DR1H 1WGCA 2SGDI 2MJHA 1K7UA 1K7TA 1UUCA 2GKTI 3TO6A 4GKKH 5CCMA 1WHRA 1K7VA 2O4CA 1XBTA 5FUXA 3UEYA 5A2QW 2UZ3A 1YTPA 2CPMA 4SGBI 2K1HA 3GR5A 5LL6b 1N33H 1FAQA 5JHWC 1VDDA 2NU3I 3FAUA 5IWAH 4FJSA 2KMOA 1PPFI 3BJIA 3J7AK 2OU2A 1PCEA 3R5BA 2KMQA 2FPHX 4B3SH 1KHMA 2JE6I 1Y1CA 1HJAI 1HEVA 2Y3MA 2E73A 1SGQI 5C0XG 2BL5A 1RFHA 1X4NA 2CTJA 2M5XA 1V9NA 1N13A 2P2RA 3GOXA 1W4RA 3D00A 3SEKC 3SB1A 1XMQH 1NUBA 4DR3H 3B4VC 2JZXA 2QPOA 1PJUA 1WVNA 4JI3H 4BA2I 2GVIA 2BA0A 1MJ9A 3PDNA 3UGIA 1Z2IA 2ARPF 4JV5H 1V8CA 1DS3I 3OVOA 1ZZJA 2V1CA 1M8BA 3TOAA 4WANA 4LF6H 4LIJA 1OYVI 4NBQA 2UXDH 2X06A 2B0UC 1WKXA 2SGPI 3R5DA 1U5KA 2HHHH 1R0RI 2ANRA 4OVOA 2UXBH 2CJSC 4DV0H 2JYYA 2NU1I 1N36H 1TGSI 2CWHA 4WALA 3R5AA 3J81W 2SGEI 5E3QA 1CSOI 1M8CA 2J87A 2CWGA 2CTEA 3RU0A 4NZTM 1UG8A 4X66H 2ENNA 3OTOH 1FKAH 3TJQA 5LMNH
chains in the Genus database with same CATH topology
4FJSA 1Z2IA 1NXUA 2CWFA 2X06A 3UOEA 1WTJA 4FJUA 3I0PA 2CWHA 4H8AA 1X0AA 1V9NA 1S20A 1VBIA 2G8YA 1XRHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FJS A;  1Z2I A;  1NXU A;  2CWF A;  2X06 A;  3UOE A;  1WTJ A;  4FJU A;  3I0P A;  2CWH A;  4H8A A;  1X0A A;  1V9N A;  1S20 A;  1VBI A;  2G8Y A;  1XRH A; 
#chains in the Genus database with same CATH topology
 1J5K A;  1Y1B A;  4OX9 H;  4DR7 H;  4JI2 H;  2NU4 I;  3VE5 A;  2Z0S A;  3T1H H;  2DGR A;  1DTJ A;  1Y8F A;  1PQX A;  1IBL H;  4K0K H;  3CXL A;  4JI1 H;  1CT4 I;  2CPQ A;  1S03 G;  5EX3 A;  3OXG A;  2A20 A;  1TUR A;  2N71 A;  2PT7 G;  5HI7 A;  1TBO A;  1X9Z A;  1UHA A;  2JVZ A;  1P9G A;  1ODH A;  1XRH A;  4DUZ H;  2ELI A;  2P6A C;  1H0Z A;  1XX6 A;  2RIJ A;  2RC4 A;  1CT2 I;  1BUS A;  3FC3 A;  1IY6 A;  3UEJ A;  5JEA G;  2ZQE A;  1J4W A;  1V1I A;  4B3M H;  4DR6 H;  2QQC A;  2DKV A;  2JXD A;  1SGY I;  2LB7 A;  4MPI A;  1TUS A;  5E3R A;  1HPT A;  4DV1 H;  3QD7 X;  2SGQ I;  2VQF H;  2VRW B;  3L7Z C;  2UUC H;  2QQD A;  2KMR A;  2JA1 A;  3QTL D;  2NU2 I;  1XMO H;  3TO9 A;  4E9J A;  1CT0 I;  1Z7K B;  2E5L H;  1CE3 A;  2E3U A;  2L7X A;  2FNF X;  1TBN A;  2SGF I;  1Q9B A;  2CTM A;  4FJU A;  5FUW A;  2LTL A;  2LF0 A;  1LR9 A;  1IBK H;  2N1A B;  2DB6 A;  4DR2 H;  2E5R A;  4OO1 G;  1LR8 A;  4B3R H;  1WGT A;  4B6D A;  4JI6 H;  1MT1 A;  5FUV A;  2JEA I;  1WTJ A;  4DV3 H;  1AN1 I;  3J80 W;  2X52 A;  3SGB I;  4JCV E;  2B8T A;  2UVO A;  4B3T H;  5E3P A;  2UXC H;  2HH2 A;  2ORV A;  1ZZK A;  1MSZ A;  3NCV A;  3RF2 A;  5FLX W;  2YUU A;  4JI7 H;  4DV7 H;  1N32 H;  5BR8 H;  4B8C D;  1CHO I;  2KMP A;  1EC6 A;  1SGE I;  1ULN A;  3OSS D;  2OZU A;  4LFA H;  3JAM W;  4LF9 H;  1FJG H;  2FFM A;  1XA6 A;  1ZTG A;  1TBQ R;  2M8W A;  1AN7 A;  2JZM A;  1OMU A;  4DV2 H;  2GIV A;  1F0X A;  3MEK A;  3KDG A;  4DV6 H;  2AXY A;  1I94 H;  2V53 A;  1N34 H;  5IT9 W;  4GKJ H;  1X4S A;  1HNW H;  1TUA A;  1PTQ A;  1VBI A;  5LMU H;  2W0T A;  1UVG A;  2N52 A;  2A1S A;  3KDK A;  4AML A;  2JA9 A;  1SGR I;  1SGN I;  4HGU A;  4JVH A;  2PY9 A;  1NXU A;  1DS2 I;  4E1P A;  1ULK A;  2ANN A;  2JEB I;  2BUS A;  4JVY A;  2Y0M A;  4DR5 H;  3E2I A;  3VDP A;  4UXH A;  4X64 H;  3TOB A;  1MJA A;  4LF8 H;  1X74 A;  2F3C I;  1OVO A;  1KBF A;  4NXN H;  2DIP A;  5FUY A;  4A24 A;  1UVF A;  4LFB H;  5HQ8 A;  4LF4 H;  2J9R A;  3OXL A;  2KCX A;  2OD1 A;  1MJB A;  4GI3 C;  2LRR A;  1IW4 A;  3UGL A;  4OD6 A;  2WGC A;  1LR7 A;  4AM3 A;  4NXM H;  3OXF A;  1HNZ H;  4H8A A;  2QQ0 A;  5J8C A;  2ENZ A;  4JI0 H;  2CWF A;  4OCH A;  4YY3 H;  3I0P A;  2OPV A;  2QND A;  2UU9 H;  2JW6 A;  2ROW A;  1W3S A;  2YQP A;  4UXI A;  1FY7 A;  1TBR R;  2N17 A;  3V69 A;  4L9M A;  1XNR H;  3VDU A;  2XRC A;  3R5C A;  2K9H A;  4LF7 H;  2CTF A;  1VIH A;  1R79 A;  5CCL A;  4PDB A;  2HH3 A;  1CGJ I;  1X4M A;  3EZJ A;  1IY5 A;  3HH2 C;  1X0A A;  2NU0 I;  3E59 A;  3UFF A;  2VQE H;  2UUB H;  2LTM A;  5DT9 A;  1J5E H;  2V1C C;  2PQU A;  2WVJ A;  3UGD A;  3GAB A;  2VKC A;  3QWP A;  4X65 H;  4B8T A;  4UXJ A;  2GKV A;  4IFD G;  1YU6 C;  1HR0 H;  2ORW A;  4FKD A;  2M6Q A;  4JI5 H;  3FSX A;  5K36 G;  1XNQ H;  1TIH A;  2QQE A;  2PQ8 A;  4LFC H;  3AEV B;  4JI8 H;  1TOT A;  5J8F A;  4QMF B;  2NN6 G;  4G08 A;  3GKU A;  2LEO A;  1PTR A;  3KY9 A;  3OL0 A;  1K1G A;  5EX0 A;  1SGP I;  1SGD I;  4NZR M;  4DV5 H;  4LF5 H;  4DNC A;  3UOE A;  2OPU A;  1KBE A;  4DR4 H;  1HDL A;  2D9I A;  1WE8 A;  4KHP H;  1ULM A;  1I6U A;  2ZM6 H;  1S20 A;  2CTL A;  4AIM A;  1BMO A;  4DV4 H;  3FSY A;  2FMR A;  3SGQ I;  3OET A;  2L8E A;  9WGA A;  1CGI I;  7WGA A;  2UUA H;  2GKR I;  2X3T A;  1V1H A;  1OMT A;  5DAE A;  4JI4 H;  4X62 H;  4YHH H;  2WCY A;  3VKE A;  2YQR A;  2OVO A;  4JYA H;  2G8Y A;  1FAR A;  3TO7 A;  4EC5 A;  2ODD A;  3QAH A;  1VIG A;  2CTK A;  1ZZI A;  1SEI A;  1IBM H;  1FYB A;  1KMA A;  4WP4 A;  2LUY A;  1HNX H;  2F4V H;  3U1K A;  2ERW A;  4E1R A;  4DUY H;  4BA1 I;  4AQY H;  1P9Z A;  3T1Y H;  1DT4 A;  4DR1 H;  1WGC A;  2SGD I;  2MJH A;  1K7U A;  1K7T A;  1UUC A;  2GKT I;  3TO6 A;  4GKK H;  5CCM A;  1WHR A;  1K7V A;  2O4C A;  1XBT A;  5FUX A;  3UEY A;  5A2Q W;  2UZ3 A;  1YTP A;  2CPM A;  4SGB I;  2K1H A;  3GR5 A;  5LL6 b;  1N33 H;  1FAQ A;  5JHW C;  1VDD A;  2NU3 I;  3FAU A;  5IWA H;  4FJS A;  2KMO A;  1PPF I;  3BJI A;  3J7A K;  2OU2 A;  1PCE A;  3R5B A;  2KMQ A;  2FPH X;  4B3S H;  1KHM A;  2JE6 I;  1Y1C A;  1HJA I;  1HEV A;  2Y3M A;  2E73 A;  1SGQ I;  5C0X G;  2BL5 A;  1RFH A;  1X4N A;  2CTJ A;  2M5X A;  1V9N A;  1N13 A;  2P2R A;  3GOX A;  1W4R A;  3D00 A;  3SEK C;  3SB1 A;  1XMQ H;  1NUB A;  4DR3 H;  3B4V C;  2JZX A;  2QPO A;  1PJU A;  1WVN A;  4JI3 H;  4BA2 I;  2GVI A;  2BA0 A;  1MJ9 A;  3PDN A;  3UGI A;  1Z2I A;  2ARP F;  4JV5 H;  1V8C A;  1DS3 I;  3OVO A;  1ZZJ A;  2V1C A;  1M8B A;  3TOA A;  4WAN A;  4LF6 H;  4LIJ A;  1OYV I;  4NBQ A;  2UXD H;  2X06 A;  2B0U C;  1WKX A;  2SGP I;  3R5D A;  1U5K A;  2HHH H;  1R0R I;  2ANR A;  4OVO A;  2UXB H;  2CJS C;  4DV0 H;  2JYY A;  2NU1 I;  1N36 H;  1TGS I;  2CWH A;  4WAL A;  3R5A A;  3J81 W;  2SGE I;  5E3Q A;  1CSO I;  1M8C A;  2J87 A;  2CWG A;  2CTE A;  3RU0 A;  4NZT M;  1UG8 A;  4X66 H;  2ENN A;  3OTO H;  1FKA H;  3TJQ A;  5LMN H; 
#chains in the Genus database with same CATH homology
 4FJS A;  1Z2I A;  1NXU A;  2CWF A;  2X06 A;  3UOE A;  1WTJ A;  4FJU A;  3I0P A;  2CWH A;  4H8A A;  1X0A A;  1V9N A;  1S20 A;  1VBI A;  2G8Y A;  1XRH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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