1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
molecule keywords pyrogenic exotoxin B
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
3BBAA 4RKXA 4D8IA 1DKIA 2JTCA 4D8BA 2UZJA 3BB7A 4D8EA 1PVJA
chains in the Genus database with same CATH superfamily
1CVZA 2FE8A 4R3DA 4OW0A 1TL9A 3O65A 3P5WA 4XZXA 2GFOA 1A6RA 3TMPA 1NQCA 1STFE 2J7QC 3MP2A 4M0WA 1NLJA 2B1MA 4X6IA 1U9VA 2G8EA 1Q6KA 2HH5A 4QH6A 1YVBA 2AS8A 5KO3A 2CB5A 2JQFR 1DKIA 2DZYA 4D8BA 2DCDA 3PHXA 2AUZA 3IUTA 1GLOA 2JQGR 4YYRA 1AYVA 7PCKA 1QXPA 3GCBA 1ZIVA 1ZCMA 3HHAA 2CIOA 4W5BA 1EWLA 4Q8GA 2YJCA 3W31A 1PPOA 3PW3A 1EF7A 3MTVA 1QDQA 3K8UA 1BQIA 4OEMA 4I04A 4N8WA 1NB5A 3C0RA 1U5IA 1YT7A 1AU4A 3PHWA 3KFQA 3K24A 2DCBA 2BDLA 2E03A 1ME4A 1CPJA 1YK8A 2R9MA 1S4VA 3IHPA 3U8EA 4X6JA 4QRGA 4BOPA 4BOUA 4DMXA 2G7YA 2VHFA 3N4CA 4D8IA 4MM3B 1IWDA 5EF4A 3IMAA 4RF0A 3WXGA 5A24A 1ITOA 4RKXA 4PP2E 1MEMA 5EZSA 3KKUA 3O1GA 4P16A 2BDZA 3HD3A 1PCIA 1CQDA 2AYOA 4P6GA 1Y08A 3ZUAA 1AYUA 4CDCB 1CB5A 9PAPA 2IBIA 4AXLA 2NQAA 3H89A 4RNAA 1TU6A 2XU3A 2XU4A 3CH2X 3I3TA 3B79A 4PI3A 1U2MA 2DC9A 2HWKA 4KLBA 3KWZA 4BOQA 1DF0A 3PRMA 2P7UA 3H8BA 2H7JA 1GECE 8PCHA 3BB7A 3H8CA 2AYNA 3CBJA 3PSEA 2Y6EA 1YALA 4PADA 1TLOA 3K9MA 2OZ2A 4YYWA 3OF9A 2DCAA 6PADA 3F5VA 1AU2A 1EWMA 2G6DA 3IFUA 4YYSA 1PIPA 5EGWA 4QRXA 1PPNA 3KSEA 1AIMA 2FO5A 3P5XA 3IOQA 4BPVA 4OVZA 2ARYA 2OULA 4MZSA 5JH3A 4YYVA 1Y4HA 4YV8A 1ATKA 1EWOA 2UZJA 3B21A 3E1ZB 2G8JA 2HHNA 5CHTA 3LFYA 2XU5A 1PVJA 5CVOB 4RY2A 3BCNA 4ZUXU 2BU3A 3V6CA 1MEGA 3PHUA 1X9YA 3N3GA 3BWKA 4XR7A 2R9OA 3OQCA 3N3KA 3OISA 1YZBA 1O0EA 4CDDB 4G54A 4QBBA 1PADA 3S3RA 1CTEA 1KHPA 3HHIA 2DC6A 1PPDA 2PNSA 1F2AA 3PNRA 1HUCB 2R6NA 4YYUA 4WURA 5JA7A 3OVZA 1F2CA 3OVXA 3IEJA 5CVNB 1PXVA 4CDFB 4YVAA 3W30A 4Q8HA 2FQ9A 2O6XA 2OP3A 1PBHA 1K3BB 2J7QA 3USVA 2FT2A 1GHHA 3F75A 4D8EA 2YJBA 2P86A 2FUDA 1KHQA 1BGOA 2BTWB 5FPWA 5CHVA 3KX1A 3ERVA 4FJCA 2ACTA 2NQGA 4BOZA 4YYQA 1JQPA 3O0UA 4FK5A 4BS6A 4CDEB 3H6SA 1XKGA 2AVWA 3AI8A 1SG2A 1BY8A 1THEA 2PBHA 2PADA 2E00A 3P5VA 2DCCA 1AU0A 1AYWA 3HWNA 3BY4A 3BOWA 2IPPB 1QMYA 3PDFA 3LXSA 2DOSA 4OELA 3E9SA 3RNVA 1CSBB 1GMYA 1U9QX 3QJ3A 1MIRA 5E6JA 3I06A 1UKFA 1U9XA 3D6SA 4BS5A 2NQDB 4W4UA 2R9CA 4EVXA 4OVZB 1KXRA 2VHSA 2XU1A 2E02A 5K16A 2GHUA 3M99A 4CZWA 4X6HA 1GCBA 2DZZA 3CBKA 1PE6A 2DJGB 4KQTA 1VJVA 1CV8A 2AU1A 4REZA 3ZNHA 3C9EA 2DC8A 1KFUL 1AECA 1MS6A 1KFXL 2B1NA 1DEUA 2F1GA 1PPPA 2HXZA 1CJLA 2DJFB 3RVVA 4BQVA 4QRVA 4HWYA 4WA6A 1M6DA 4I07A 4BOSA 2DC7A 1U9WA 4PT5A 4ZTBA 1ME3A 1VSNA 3S3QA 4MSXA 4N4ZA 4MI7A 3CH3X 2F7DA 1YK7A 4A5UA 4PP1A 1NL6A 2YJ9A 3BBAA 3BPMA 5CVMA 1NPZA 3P5UA 1F2BA 2JTCA 3RVXA 2AIMA 4HXDB 4K7CA 3QT4A 3PT2A 2HD5A 4IP3A 2Z84A 3KW9A 3DF0A 1CS8A 4I05A 3PRPA 2AUXA 4DMYA 3BPFA 2PREA 4BSQA 3WXFA 1QOLA 1MHWA 4FIPA 4N79A 4AXMA 2WBFX 1BP4A 1SP4B 2YJ8A 2FYEA 1MDWA 1SNKA 2C0YA 1F29A 4IUMA 3PBHA 5PADA 4XUIA 1NB3A 2NQIA 2E01A 3MORA 2AGAA 3MJ5A 3MHHA 3IV2A 4RF1A 3V6EA 2ATOA 2Y5BA 2R9FA 3NHEA 1POPA 3RVWA 3TNXA 5JZEA 3H7DA 3MHSA 2P0RA 1AU3A 1ICFA 2FRAA 2R9NA 2YJ2A 2JRIA 3QSDA 2FRQA 3OF8A 4P6EA 5EZQA 1EWPA 3MTNA 2FTDA 3KWBX 3BC3A 3WXEA 3TRKA 4W5CA 4MZOA 2BTWA 5J94A 4GUAA 1FH0A 5F02A
chains in the Genus database with same CATH topology
2FE8A 4R3DA 4OW0A 4BOSA 3O65A 4PT5A 4XZXA 4ZTBA 3TMPA 2J7QC 3MP2A 4M0WA 4WURA 4MI7A 4A5UA 3W30A 4RNAA 3BBAA 2JTCA 2J7QA 2HWKA 4HXDB 4BOQA 5KO3A 3PT2A 4IP3A 3PRMA 1DKIA 4D8BA 3BB7A 4D8EA 2Z84A 3PHXA 2BTWB 3PSEA 3PRPA 4BOZA 3W31A 3IFUA 3MTVA 3BY4A 3C0RA 2DOSA 3E9SA 3RNVA 4OVZA 3PHWA 5E6JA 1UKFA 4IUMA 4EVXA 4OVZB 2UZJA 3B21A 2AGAA 3MJ5A 4RF1A 4BOPA 1PVJA 5JZEA 4BOUA 2BU3A 4D8IA 4MM3B 3PHUA 4RF0A 2JRIA 3OQCA 4REZA 4RKXA 3ZNHA 5EZQA 1YZBA 5EZSA 4P16A 3TRKA 2BTWA 4GUAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BBA A;  4RKX A;  4D8I A;  1DKI A;  2JTC A;  4D8B A;  2UZJ A;  3BB7 A;  4D8E A;  1PVJ A; 
#chains in the Genus database with same CATH topology
 1CVZ A;  2FE8 A;  4R3D A;  4OW0 A;  1TL9 A;  3O65 A;  3P5W A;  4XZX A;  2GFO A;  1A6R A;  3TMP A;  1NQC A;  1STF E;  2J7Q C;  3MP2 A;  4M0W A;  1NLJ A;  2B1M A;  4X6I A;  1U9V A;  2G8E A;  1Q6K A;  2HH5 A;  4QH6 A;  1YVB A;  2AS8 A;  5KO3 A;  2CB5 A;  2JQF R;  1DKI A;  2DZY A;  4D8B A;  2DCD A;  3PHX A;  2AUZ A;  3IUT A;  1GLO A;  2JQG R;  4YYR A;  1AYV A;  7PCK A;  1QXP A;  3GCB A;  1ZIV A;  1ZCM A;  3HHA A;  2CIO A;  4W5B A;  1EWL A;  4Q8G A;  2YJC A;  3W31 A;  1PPO A;  3PW3 A;  1EF7 A;  3MTV A;  1QDQ A;  3K8U A;  1BQI A;  4OEM A;  4I04 A;  4N8W A;  1NB5 A;  3C0R A;  1U5I A;  1YT7 A;  1AU4 A;  3PHW A;  3KFQ A;  3K24 A;  2DCB A;  2BDL A;  2E03 A;  1ME4 A;  1CPJ A;  1YK8 A;  2R9M A;  1S4V A;  3IHP A;  3U8E A;  4X6J A;  4QRG A;  4BOP A;  4BOU A;  4DMX A;  2G7Y A;  2VHF A;  3N4C A;  4D8I A;  4MM3 B;  1IWD A;  5EF4 A;  3IMA A;  4RF0 A;  3WXG A;  5A24 A;  1ITO A;  4RKX A;  4PP2 E;  1MEM A;  5EZS A;  3KKU A;  3O1G A;  4P16 A;  2BDZ A;  3HD3 A;  1PCI A;  1CQD A;  2AYO A;  4P6G A;  1Y08 A;  3ZUA A;  1AYU A;  4CDC B;  1CB5 A;  9PAP A;  2IBI A;  4AXL A;  2NQA A;  3H89 A;  4RNA A;  1TU6 A;  2XU3 A;  2XU4 A;  3CH2 X;  3I3T A;  3B79 A;  4PI3 A;  1U2M A;  2DC9 A;  2HWK A;  4KLB A;  3KWZ A;  4BOQ A;  1DF0 A;  3PRM A;  2P7U A;  3H8B A;  2H7J A;  1GEC E;  8PCH A;  3BB7 A;  3H8C A;  2AYN A;  3CBJ A;  3PSE A;  2Y6E A;  1YAL A;  4PAD A;  1TLO A;  3K9M A;  2OZ2 A;  4YYW A;  3OF9 A;  2DCA A;  6PAD A;  3F5V A;  1AU2 A;  1EWM A;  2G6D A;  3IFU A;  4YYS A;  1PIP A;  5EGW A;  4QRX A;  1PPN A;  3KSE A;  1AIM A;  2FO5 A;  3P5X A;  3IOQ A;  4BPV A;  4OVZ A;  2ARY A;  2OUL A;  4MZS A;  5JH3 A;  4YYV A;  1Y4H A;  4YV8 A;  1ATK A;  1EWO A;  2UZJ A;  3B21 A;  3E1Z B;  2G8J A;  2HHN A;  5CHT A;  3LFY A;  2XU5 A;  1PVJ A;  5CVO B;  4RY2 A;  3BCN A;  4ZUX U;  2BU3 A;  3V6C A;  1MEG A;  3PHU A;  1X9Y A;  3N3G A;  3BWK A;  4XR7 A;  2R9O A;  3OQC A;  3N3K A;  3OIS A;  1YZB A;  1O0E A;  4CDD B;  4G54 A;  4QBB A;  1PAD A;  3S3R A;  1CTE A;  1KHP A;  3HHI A;  2DC6 A;  1PPD A;  2PNS A;  1F2A A;  3PNR A;  1HUC B;  2R6N A;  4YYU A;  4WUR A;  5JA7 A;  3OVZ A;  1F2C A;  3OVX A;  3IEJ A;  5CVN B;  1PXV A;  4CDF B;  4YVA A;  3W30 A;  4Q8H A;  2FQ9 A;  2O6X A;  2OP3 A;  1PBH A;  1K3B B;  2J7Q A;  3USV A;  2FT2 A;  1GHH A;  3F75 A;  4D8E A;  2YJB A;  2P86 A;  2FUD A;  1KHQ A;  1BGO A;  2BTW B;  5FPW A;  5CHV A;  3KX1 A;  3ERV A;  4FJC A;  2ACT A;  2NQG A;  4BOZ A;  4YYQ A;  1JQP A;  3O0U A;  4FK5 A;  4BS6 A;  4CDE B;  3H6S A;  1XKG A;  2AVW A;  3AI8 A;  1SG2 A;  1BY8 A;  1THE A;  2PBH A;  2PAD A;  2E00 A;  3P5V A;  2DCC A;  1AU0 A;  1AYW A;  3HWN A;  3BY4 A;  3BOW A;  2IPP B;  1QMY A;  3PDF A;  3LXS A;  2DOS A;  4OEL A;  3E9S A;  3RNV A;  1CSB B;  1GMY A;  1U9Q X;  3QJ3 A;  1MIR A;  5E6J A;  3I06 A;  1UKF A;  1U9X A;  3D6S A;  4BS5 A;  2NQD B;  4W4U A;  2R9C A;  4EVX A;  4OVZ B;  1KXR A;  2VHS A;  2XU1 A;  2E02 A;  5K16 A;  2GHU A;  3M99 A;  4CZW A;  4X6H A;  1GCB A;  2DZZ A;  3CBK A;  1PE6 A;  2DJG B;  4KQT A;  1VJV A;  1CV8 A;  2AU1 A;  4REZ A;  3ZNH A;  3C9E A;  2DC8 A;  1KFU L;  1AEC A;  1MS6 A;  1KFX L;  2B1N A;  1DEU A;  2F1G A;  1PPP A;  2HXZ A;  1CJL A;  2DJF B;  3RVV A;  4BQV A;  4QRV A;  4HWY A;  4WA6 A;  1M6D A;  4I07 A;  4BOS A;  2DC7 A;  1U9W A;  4PT5 A;  4ZTB A;  1ME3 A;  1VSN A;  3S3Q A;  4MSX A;  4N4Z A;  4MI7 A;  3CH3 X;  2F7D A;  1YK7 A;  4A5U A;  4PP1 A;  1NL6 A;  2YJ9 A;  3BBA A;  3BPM A;  5CVM A;  1NPZ A;  3P5U A;  1F2B A;  2JTC A;  3RVX A;  2AIM A;  4HXD B;  4K7C A;  3QT4 A;  3PT2 A;  2HD5 A;  4IP3 A;  2Z84 A;  3KW9 A;  3DF0 A;  1CS8 A;  4I05 A;  3PRP A;  2AUX A;  4DMY A;  3BPF A;  2PRE A;  4BSQ A;  3WXF A;  1QOL A;  1MHW A;  4FIP A;  4N79 A;  4AXM A;  2WBF X;  1BP4 A;  1SP4 B;  2YJ8 A;  2FYE A;  1MDW A;  1SNK A;  2C0Y A;  1F29 A;  4IUM A;  3PBH A;  5PAD A;  4XUI A;  1NB3 A;  2NQI A;  2E01 A;  3MOR A;  2AGA A;  3MJ5 A;  3MHH A;  3IV2 A;  4RF1 A;  3V6E A;  2ATO A;  2Y5B A;  2R9F A;  3NHE A;  1POP A;  3RVW A;  3TNX A;  5JZE A;  3H7D A;  3MHS A;  2P0R A;  1AU3 A;  1ICF A;  2FRA A;  2R9N A;  2YJ2 A;  2JRI A;  3QSD A;  2FRQ A;  3OF8 A;  4P6E A;  5EZQ A;  1EWP A;  3MTN A;  2FTD A;  3KWB X;  3BC3 A;  3WXE A;  3TRK A;  4W5C A;  4MZO A;  2BTW A;  5J94 A;  4GUA A;  1FH0 A;  5F02 A; 
#chains in the Genus database with same CATH homology
 2FE8 A;  4R3D A;  4OW0 A;  4BOS A;  3O65 A;  4PT5 A;  4XZX A;  4ZTB A;  3TMP A;  2J7Q C;  3MP2 A;  4M0W A;  4WUR A;  4MI7 A;  4A5U A;  3W30 A;  4RNA A;  3BBA A;  2JTC A;  2J7Q A;  2HWK A;  4HXD B;  4BOQ A;  5KO3 A;  3PT2 A;  4IP3 A;  3PRM A;  1DKI A;  4D8B A;  3BB7 A;  4D8E A;  2Z84 A;  3PHX A;  2BTW B;  3PSE A;  3PRP A;  4BOZ A;  3W31 A;  3IFU A;  3MTV A;  3BY4 A;  3C0R A;  2DOS A;  3E9S A;  3RNV A;  4OVZ A;  3PHW A;  5E6J A;  1UKF A;  4IUM A;  4EVX A;  4OVZ B;  2UZJ A;  3B21 A;  2AGA A;  3MJ5 A;  4RF1 A;  4BOP A;  1PVJ A;  5JZE A;  4BOU A;  2BU3 A;  4D8I A;  4MM3 B;  3PHU A;  4RF0 A;  2JRI A;  3OQC A;  4REZ A;  4RKX A;  3ZNH A;  5EZQ A;  1YZB A;  5EZS A;  4P16 A;  3TRK A;  2BTW A;  4GUA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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