1PVJA

Crystal structure of the streptococcal pyrogenic exotoxin b (speb)- inhibitor complex
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
339
Chain Sequence
FARNEKEAKDSAITFIQKIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPGFNGYQSAVVGIKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
rcsb
molecule tags Toxin
molecule keywords pyrogenic exotoxin B
total genus 105
structure length 339
sequence length 368
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2003-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01640 Peptidase_C10 Peptidase C10 family
A PF13734 Inhibitor_I69 Spi protease inhibitor
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.910.30 Alpha Beta 2-Layer Sandwich Protein Binding, DinI Protein; Chain A Protein Binding, DinI Protein; Chain A 1pvjA02
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 1pvjA01
3BB7A 2UZJA 3BBAA 4RKXA 1PVJA 1DKIA 2JTCA 4D8IA 4D8EA 4D8BA
chains in the Genus database with same CATH superfamily
3PHUA 3LXSA 3HHAA 5PADA 3H6SA 1YZBA 2CB5A 4MSXA 4QRXA 4IP3A 4P6EA 1TU6A 3F5VA 4QRVA 4N79A 3IUTA 2J7QC 4FJCA 1O0EA 1Q6KA 3K24A 2DC7A 3N3KA 2AYNA 4ZTBA 2AGAA 2PADA 1AYWA 4YYWA 3MHHA 2DC6A 3BY4A 3KW9A 1F2CA 2R6NA 3OF8A 4M0WA 2AUXA 1GECE 3ZNHA 5CVMA 4CDDB 2Y6EA 2PNSA 2AIMA 3TRKA 3WXGA 3TMPA 1QDQA 3OISA 4Q8GA 2FUDA 1CJLA 4FK5A 1MS6A 3CH3X 3IFUA 4BS6A 3PBHA 4GUAA 1EWLA 5EGWA 3PW3A 3KWBX 4YYUA 3W30A 3P5XA 2BTWB 4K7CA 3BBAA 2CIOA 4N8WA 2DZZA 2H7JA 1KHQA 4REZA 5KO3A 1X9YA 1NQCA 4BOPA 1U9WA 3V6EA 4OVZB 3W31A 4YYSA 2P86A 1U9VA 2IBIA 4X6JA 2DCCA 2JRIA 3KFQA 4WURA 2OZ2A 1VSNA 4AXMA 4CZWA 1POPA 3P5UA 3WXEA 2E02A 4RF0A 3PDFA 1CQDA 3O1GA 4BOSA 5EZSA 1BP4A 4P16A 2G8EA 3BOWA 3H8BA 1QMYA 3RNVA 2ACTA 4YV8A 2NQGA 4R3DA 3PRMA 4FIPA 3RVVA 4QH6A 1SG2A 3NHEA 3ZUAA 1Y08A 2G7YA 2HXZA 2HH5A 4YYVA 1U5IA 1QOLA 1F2BA 3E1ZB 4OELA 3QT4A 4X6HA 2XU3A 3MJ5A 4BOQA 2E00A 1VJVA 4BSQA 2FE8A 3E9SA 1FH0A 3PRPA 4D8EA 9PAPA 2VHFA 2YJCA 5CVOB 4YYRA 1U9XA 1BQIA 4HXDB 3GCBA 2FYEA 3PHXA 2AVWA 3I3TA 3KX1A 2PBHA 2BU3A 4AXLA 2VHSA 4PP1A 2DCAA 3B21A 4G54A 3RVXA 4I07A 1YALA 1AECA 4I04A 4XZXA 8PCHA 4RNAA 2G8JA 4I05A 4BQVA 4DMXA 1CTEA 1AU0A 2XU5A 4MZSA 2DJFB 4BS5A 2PREA 1THEA 1ME4A 1GHHA 3PNRA 2YJBA 1AU2A 2YJ2A 3O65A 4XR7A 4BOZA 3B79A 3OF9A 2WBFX 4X6IA 2HWKA 4YYQA 3HWNA 1KHPA 3CBJA 1CS8A 1U2MA 2HHNA 1CPJA 1TL9A 1AYVA 2DC8A 3F75A 1IWDA 3C0RA 3CH2X 3H89A 2ARYA 4OEMA 1Y4HA 3WXFA 1KXRA 4BPVA 2GHUA 4ZUXU 4PI3A 1ME3A 1M6DA 3DF0A 5K16A 1EWPA 4DMYA 1F2AA 3QSDA 4PADA 3O0UA 4W4UA 2R9CA 4W5CA 1S4VA 2R9NA 3MTNA 1GMYA 3P5VA 1XKGA 2DJGB 4MM3B 2OP3A 1NB3A 3IV2A 2OULA 2DCBA 4PP2E 2DCDA 1MHWA 1NLJA 4P6GA 2JQFR 3H7DA 4D8BA 2GFOA 3I06A 1DKIA 3MP2A 5JH3A 4N4ZA 2R9OA 2UZJA 3S3RA 3IMAA 3PHWA 4Q8HA 4D8IA 3BB7A 2Z84A 2E03A 5EZQA 2DC9A 1EWOA 3BCNA 2B1NA 5EF4A 1AU3A 3PSEA 1MEGA 2R9FA 1CSBB 5JA7A 1MEMA 3RVWA 1ATKA 2BDZA 4QBBA 5FPWA 2O6XA 4EVXA 3S3QA 3HD3A 2F1GA 3N4CA 4KLBA 1AYUA 1SP4B 3HHIA 2HD5A 3BWKA 3IEJA 2JTCA 5CVNB 3OQCA 1U9QX 1PPOA 1QXPA 5E6JA 1ZIVA 4A5UA 3MTVA 2R9MA 2DZYA 2FRQA 2G6DA 2YJ9A 3IOQA 3P5WA 1AIMA 2AYOA 3PT2A 4KQTA 4RF1A 6PADA 3AI8A 1BGOA 2BDLA 1SNKA 2FT2A 1PPPA 1PVJA 2BTWA 1GLOA 1AU4A 1YT7A 4PT5A 2FQ9A 4W5BA 1PBHA 5J94A 1UKFA 4RY2A 4HWYA 1EWMA 1JQPA 4OVZA 2C0YA 1PCIA 2FO5A 3LFYA 3MHSA 3CBKA 4MI7A 2FRAA 1CB5A 1PADA 3OVZA 7PCKA 1TLOA 3ERVA 2IPPB 4MZOA 2P7UA 1KFXL 3V6CA 4CDFB 2AS8A 4BOUA 2E01A 3U8EA 3KSEA 1PIPA 2AUZA 3C9EA 1YK8A 3QJ3A 3KKUA 5F02A 1MIRA 4RKXA 1CV8A 2NQIA 1ICFA 2DOSA 4YVAA 1F29A 1GCBA 3KWZA 1K3BB 1PPNA 3K8UA 3BPFA 4CDCB 1DF0A 1DEUA 1ZCMA 1CVZA 1NPZA 3H8CA 1MDWA 1HUCB 4XUIA 3MORA 2YJ8A 2FTDA 1STFE 1YK7A 2XU1A 1EF7A 1BY8A 3D6SA 2B1MA 2F7DA 3M99A 5CHVA 4WA6A 3N3GA 4CDEB 1NL6A 4IUMA 2J7QA 1A6RA 3IHPA 3K9MA 2ATOA 2XU4A 3BC3A 1PE6A 2P0RA 3TNXA 1PPDA 5JZEA 4QRGA 1NB5A 2AU1A 2Y5BA 1YVBA 1ITOA 3USVA 4OW0A 1PXVA 3BPMA 3OVXA 2NQAA 1KFUL 2JQGR 5A24A 5CHTA 2NQDB
chains in the Genus database with same CATH topology
3PHUA 1PVJA 4R3DA 2BTWA 3PRMA 1YZBA 4IP3A 4PT5A 1UKFA 2J7QC 4OVZA 4MM3B 4MI7A 4ZTBA 2AGAA 3MJ5A 4BOQA 4D8BA 3BY4A 2FE8A 3E9SA 1DKIA 3PRPA 3MP2A 4D8EA 4M0WA 2UZJA 4BOUA 3ZNHA 4HXDB 3PHXA 3PHWA 4RKXA 2DOSA 2BU3A 3TRKA 4D8IA 3BB7A 3B21A 3TMPA 2Z84A 5EZQA 4XZXA 4RNAA 3IFUA 4GUAA 3W30A 2BTWB 3PSEA 3BBAA 4REZA 5KO3A 4EVXA 4BOPA 4OVZB 4IUMA 2J7QA 3W31A 3O65A 4BOZA 2JRIA 4WURA 2JTCA 3OQCA 5JZEA 5E6JA 4A5UA 3MTVA 2HWKA 4RF0A 4OW0A 3PT2A 4BOSA 4RF1A 5EZSA 4P16A 3C0RA 3RNVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BB7 A;  2UZJ A;  3BBA A;  4RKX A;  1PVJ A;  1DKI A;  2JTC A;  4D8I A;  4D8E A;  4D8B A; 
#chains in the Genus database with same CATH topology
 3PHU A;  3LXS A;  3HHA A;  5PAD A;  3H6S A;  1YZB A;  2CB5 A;  4MSX A;  4QRX A;  4IP3 A;  4P6E A;  1TU6 A;  3F5V A;  4QRV A;  4N79 A;  3IUT A;  2J7Q C;  4FJC A;  1O0E A;  1Q6K A;  3K24 A;  2DC7 A;  3N3K A;  2AYN A;  4ZTB A;  2AGA A;  2PAD A;  1AYW A;  4YYW A;  3MHH A;  2DC6 A;  3BY4 A;  3KW9 A;  1F2C A;  2R6N A;  3OF8 A;  4M0W A;  2AUX A;  1GEC E;  3ZNH A;  5CVM A;  4CDD B;  2Y6E A;  2PNS A;  2AIM A;  3TRK A;  3WXG A;  3TMP A;  1QDQ A;  3OIS A;  4Q8G A;  2FUD A;  1CJL A;  4FK5 A;  1MS6 A;  3CH3 X;  3IFU A;  4BS6 A;  3PBH A;  4GUA A;  1EWL A;  5EGW A;  3PW3 A;  3KWB X;  4YYU A;  3W30 A;  3P5X A;  2BTW B;  4K7C A;  3BBA A;  2CIO A;  4N8W A;  2DZZ A;  2H7J A;  1KHQ A;  4REZ A;  5KO3 A;  1X9Y A;  1NQC A;  4BOP A;  1U9W A;  3V6E A;  4OVZ B;  3W31 A;  4YYS A;  2P86 A;  1U9V A;  2IBI A;  4X6J A;  2DCC A;  2JRI A;  3KFQ A;  4WUR A;  2OZ2 A;  1VSN A;  4AXM A;  4CZW A;  1POP A;  3P5U A;  3WXE A;  2E02 A;  4RF0 A;  3PDF A;  1CQD A;  3O1G A;  4BOS A;  5EZS A;  1BP4 A;  4P16 A;  2G8E A;  3BOW A;  3H8B A;  1QMY A;  3RNV A;  2ACT A;  4YV8 A;  2NQG A;  4R3D A;  3PRM A;  4FIP A;  3RVV A;  4QH6 A;  1SG2 A;  3NHE A;  3ZUA A;  1Y08 A;  2G7Y A;  2HXZ A;  2HH5 A;  4YYV A;  1U5I A;  1QOL A;  1F2B A;  3E1Z B;  4OEL A;  3QT4 A;  4X6H A;  2XU3 A;  3MJ5 A;  4BOQ A;  2E00 A;  1VJV A;  4BSQ A;  2FE8 A;  3E9S A;  1FH0 A;  3PRP A;  4D8E A;  9PAP A;  2VHF A;  2YJC A;  5CVO B;  4YYR A;  1U9X A;  1BQI A;  4HXD B;  3GCB A;  2FYE A;  3PHX A;  2AVW A;  3I3T A;  3KX1 A;  2PBH A;  2BU3 A;  4AXL A;  2VHS A;  4PP1 A;  2DCA A;  3B21 A;  4G54 A;  3RVX A;  4I07 A;  1YAL A;  1AEC A;  4I04 A;  4XZX A;  8PCH A;  4RNA A;  2G8J A;  4I05 A;  4BQV A;  4DMX A;  1CTE A;  1AU0 A;  2XU5 A;  4MZS A;  2DJF B;  4BS5 A;  2PRE A;  1THE A;  1ME4 A;  1GHH A;  3PNR A;  2YJB A;  1AU2 A;  2YJ2 A;  3O65 A;  4XR7 A;  4BOZ A;  3B79 A;  3OF9 A;  2WBF X;  4X6I A;  2HWK A;  4YYQ A;  3HWN A;  1KHP A;  3CBJ A;  1CS8 A;  1U2M A;  2HHN A;  1CPJ A;  1TL9 A;  1AYV A;  2DC8 A;  3F75 A;  1IWD A;  3C0R A;  3CH2 X;  3H89 A;  2ARY A;  4OEM A;  1Y4H A;  3WXF A;  1KXR A;  4BPV A;  2GHU A;  4ZUX U;  4PI3 A;  1ME3 A;  1M6D A;  3DF0 A;  5K16 A;  1EWP A;  4DMY A;  1F2A A;  3QSD A;  4PAD A;  3O0U A;  4W4U A;  2R9C A;  4W5C A;  1S4V A;  2R9N A;  3MTN A;  1GMY A;  3P5V A;  1XKG A;  2DJG B;  4MM3 B;  2OP3 A;  1NB3 A;  3IV2 A;  2OUL A;  2DCB A;  4PP2 E;  2DCD A;  1MHW A;  1NLJ A;  4P6G A;  2JQF R;  3H7D A;  4D8B A;  2GFO A;  3I06 A;  1DKI A;  3MP2 A;  5JH3 A;  4N4Z A;  2R9O A;  2UZJ A;  3S3R A;  3IMA A;  3PHW A;  4Q8H A;  4D8I A;  3BB7 A;  2Z84 A;  2E03 A;  5EZQ A;  2DC9 A;  1EWO A;  3BCN A;  2B1N A;  5EF4 A;  1AU3 A;  3PSE A;  1MEG A;  2R9F A;  1CSB B;  5JA7 A;  1MEM A;  3RVW A;  1ATK A;  2BDZ A;  4QBB A;  5FPW A;  2O6X A;  4EVX A;  3S3Q A;  3HD3 A;  2F1G A;  3N4C A;  4KLB A;  1AYU A;  1SP4 B;  3HHI A;  2HD5 A;  3BWK A;  3IEJ A;  2JTC A;  5CVN B;  3OQC A;  1U9Q X;  1PPO A;  1QXP A;  5E6J A;  1ZIV A;  4A5U A;  3MTV A;  2R9M A;  2DZY A;  2FRQ A;  2G6D A;  2YJ9 A;  3IOQ A;  3P5W A;  1AIM A;  2AYO A;  3PT2 A;  4KQT A;  4RF1 A;  6PAD A;  3AI8 A;  1BGO A;  2BDL A;  1SNK A;  2FT2 A;  1PPP A;  1PVJ A;  2BTW A;  1GLO A;  1AU4 A;  1YT7 A;  4PT5 A;  2FQ9 A;  4W5B A;  1PBH A;  5J94 A;  1UKF A;  4RY2 A;  4HWY A;  1EWM A;  1JQP A;  4OVZ A;  2C0Y A;  1PCI A;  2FO5 A;  3LFY A;  3MHS A;  3CBK A;  4MI7 A;  2FRA A;  1CB5 A;  1PAD A;  3OVZ A;  7PCK A;  1TLO A;  3ERV A;  2IPP B;  4MZO A;  2P7U A;  1KFX L;  3V6C A;  4CDF B;  2AS8 A;  4BOU A;  2E01 A;  3U8E A;  3KSE A;  1PIP A;  2AUZ A;  3C9E A;  1YK8 A;  3QJ3 A;  3KKU A;  5F02 A;  1MIR A;  4RKX A;  1CV8 A;  2NQI A;  1ICF A;  2DOS A;  4YVA A;  1F29 A;  1GCB A;  3KWZ A;  1K3B B;  1PPN A;  3K8U A;  3BPF A;  4CDC B;  1DF0 A;  1DEU A;  1ZCM A;  1CVZ A;  1NPZ A;  3H8C A;  1MDW A;  1HUC B;  4XUI A;  3MOR A;  2YJ8 A;  2FTD A;  1STF E;  1YK7 A;  2XU1 A;  1EF7 A;  1BY8 A;  3D6S A;  2B1M A;  2F7D A;  3M99 A;  5CHV A;  4WA6 A;  3N3G A;  4CDE B;  1NL6 A;  4IUM A;  2J7Q A;  1A6R A;  3IHP A;  3K9M A;  2ATO A;  2XU4 A;  3BC3 A;  1PE6 A;  2P0R A;  3TNX A;  1PPD A;  5JZE A;  4QRG A;  1NB5 A;  2AU1 A;  2Y5B A;  1YVB A;  1ITO A;  3USV A;  4OW0 A;  1PXV A;  3BPM A;  3OVX A;  2NQA A;  1KFU L;  2JQG R;  5A24 A;  5CHT A;  2NQD B; 
#chains in the Genus database with same CATH homology
 3PHU A;  1PVJ A;  4R3D A;  2BTW A;  3PRM A;  1YZB A;  4IP3 A;  4PT5 A;  1UKF A;  2J7Q C;  4OVZ A;  4MM3 B;  4MI7 A;  4ZTB A;  2AGA A;  3MJ5 A;  4BOQ A;  4D8B A;  3BY4 A;  2FE8 A;  3E9S A;  1DKI A;  3PRP A;  3MP2 A;  4D8E A;  4M0W A;  2UZJ A;  4BOU A;  3ZNH A;  4HXD B;  3PHX A;  3PHW A;  4RKX A;  2DOS A;  2BU3 A;  3TRK A;  4D8I A;  3BB7 A;  3B21 A;  3TMP A;  2Z84 A;  5EZQ A;  4XZX A;  4RNA A;  3IFU A;  4GUA A;  3W30 A;  2BTW B;  3PSE A;  3BBA A;  4REZ A;  5KO3 A;  4EVX A;  4BOP A;  4OVZ B;  4IUM A;  2J7Q A;  3W31 A;  3O65 A;  4BOZ A;  2JRI A;  4WUR A;  2JTC A;  3OQC A;  5JZE A;  5E6J A;  4A5U A;  3MTV A;  2HWK A;  4RF0 A;  4OW0 A;  3PT2 A;  4BOS A;  4RF1 A;  5EZS A;  4P16 A;  3C0R A;  3RNV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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