1YT7A

Cathepsin k complexed with a constrained ketoamide inhibitor
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
214
structure length
214
Chain Sequence
PDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title P(2)-P(3) conformationally constrained ketoamide-based inhibitors of cathepsin K.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Cathepsin K
total genus 65
structure length 214
sequence length 214
ec nomenclature ec 3.4.22.38: Cathepsin K.
pdb deposition date 2005-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 1yt7A00
1TLOA 2DC6A 2HXZA 4CDCB 1QOLA 3BPFA 4AXLA 5F02A 3MTNA 2FYEA 2E02A 2F7DA 3O0UA 1AYUA 1QDQA 2FTDA 1PCIA 2GFOA 1NPZA 3KFQA 4W5BA 5EF4A 3KKUA 3BC3A 5PADA 1AECA 4W5CA 4PI3A 2DC9A 1ATKA 2HHNA 3P5XA 1PPNA 4OEMA 2PADA 3I06A 2AYOA 3H8BA 4FK5A 2OULA 3KWZA 4XR7A 1QMYA 1CS8A 3HWNA 4PP1A 4CDEB 3M99A 1VJVA 1M6DA 1KFUL 1CB5A 2FRAA 2DCCA 3C9EA 2E03A 1Y4HA 2IPPB 2YJ9A 1AYVA 3O1GA 1KHQA 2P7UA 3K8UA 1EWPA 4WA6A 2FUDA 2H7JA 4QRVA 1NB3A 3U8EA 2FO5A 4K7CA 1THEA 3MHHA 1U5IA 1NLJA 2G8EA 4YYRA 4I04A 2DJGB 2R9NA 2DC8A 3LFYA 1EWLA 1PE6A 3HHIA 9PAPA 2JQGR 2PBHA 4KLBA 5J94A 3MHSA 2AUZA 2R9OA 3QSDA 1ZIVA 1QXPA 2AU1A 1MS6A 3KWBX 1SNKA 1F2BA 2VHFA 1XKGA 3S3RA 1BP4A 4N4ZA 7PCKA 1STFE 3K24A 2R9MA 3IEJA 2YJBA 2HH5A 3PW3A 3I3TA 1O0EA 4ZUXU 2DCBA 1YT7A 2B1MA 2NQDB 1MIRA 4X6HA 3CH2X 3TNXA 3IHPA 4QH6A 3F75A 3H8CA 3PNRA 2PREA 1MEMA 2G8JA 2DZYA 4QBBA 1PPPA 1POPA 2IBIA 3IMAA 3CH3X 1FH0A 3KW9A 4YYVA 2O6XA 2YJCA 2DC7A 4P6EA 3F5VA 2DCAA 3PDFA 1U9QX 3AI8A 1CPJA 3NHEA 3BCNA 5EGWA 3GCBA 3N3GA 2BDLA 1Y08A 5K16A 4X6IA 6PADA 3QJ3A 3N4CA 3RVVA 4I05A 2WBFX 3V6CA 3BPMA 1PXVA 4N8WA 1AU4A 1NB5A 1AIMA 3H7DA 1YVBA 1DF0A 1PADA 1ITOA 3BWKA 3DF0A 3KSEA 2E01A 2ARYA 3PBHA 3P5VA 4YYUA 3RVXA 2XU4A 3OF8A 2NQGA 1CQDA 2GHUA 4BQVA 2YJ2A 2DCDA 3K9MA 1BQIA 1AU3A 4CDDB 4QRGA 3ZUAA 3E1ZB 2P86A 1TL9A 1AYWA 2VHSA 2F1GA 3OF9A 4AXMA 2ATOA 1U9XA 5CVMA 1F2CA 3D6SA 1NQCA 8PCHA 1PPOA 1EWOA 3P5UA 3HHAA 1JQPA 5CVNB 1GLOA 3RVWA 1X9YA 5CVOB 2P0RA 3IUTA 3H89A 4G54A 2CIOA 1S4VA 3KX1A 4W4UA 2PNSA 1BGOA 4YYSA 2C0YA 2OZ2A 2DZZA 4XUIA 4BS6A 4YYWA 3ERVA 2Y5BA 2XU5A 4BSQA 3IV2A 4OELA 4YVAA 1YALA 1NL6A 4Q8GA 1F2AA 2JQFR 1GECE 4MZSA 4DMYA 1PPDA 4PP2E 1KFXL 3CBKA 5CHTA 2AIMA 2R9FA 5JA7A 1Q6KA 1VSNA 2AVWA 1BY8A 4FIPA 1EWMA 3LXSA 4Q8HA 2FQ9A 4MSXA 3BOWA 1GCBA 3MORA 1ME3A 3B79A 3IOQA 4MZOA 1AU0A 2NQIA 4DMXA 3HD3A 3P5WA 1MHWA 1GMYA 1MDWA 4N79A 2HD5A 2B1NA 1IWDA 4I07A 1CJLA 4BPVA 4RY2A 2R9CA 2AS8A 3V6EA 5JH3A 2AYNA 1U9WA 2XU3A 1YK7A 4X6JA 2NQAA 1ME4A 1U9VA 1A6RA 2FT2A 2G6DA 2OP3A 3H6SA 1PIPA 1EF7A 2G7YA 4BS5A 2Y6EA 1KHPA 4CDFB 3QT4A 1MEGA 2CB5A 3OISA 1YK8A 3USVA 2AUXA 4CZWA 4YYQA 5A24A 4HWYA 1KXRA 2DJFB 2BDZA 2XU1A 3N3KA 1CVZA 3WXFA 3S3QA 1K3BB 4PADA 1F29A 1HUCB 2YJ8A 4YV8A 3OVXA 5CHVA 1DEUA 2FRQA 4FJCA 1PBHA 1CSBB 3WXEA 1CV8A 1ICFA 5FPWA 1TU6A 2R6NA 4QRXA 1SP4B 4P6GA 3CBJA 2ACTA 3WXGA 1AU2A 2E00A 1ZCMA 3OVZA 1CTEA
chains in the Genus database with same CATH superfamily
1TLOA 2DC6A 2HXZA 4CDCB 1QOLA 3BPFA 4AXLA 5F02A 3MTNA 4IP3A 2FYEA 2E02A 2F7DA 3O0UA 1AYUA 4BOSA 1QDQA 2FTDA 1PCIA 2GFOA 1NPZA 3KFQA 4W5BA 5EF4A 3KKUA 3BC3A 5PADA 1AECA 4W5CA 4PI3A 2DC9A 1ATKA 2HHNA 3P5XA 1PPNA 4OEMA 2PADA 3I06A 2AYOA 3C0RA 3H8BA 4FK5A 4RF1A 2OULA 2BTWA 3KWZA 4XR7A 1QMYA 1CS8A 3HWNA 4D8IA 4PP1A 4CDEB 4RKXA 3M99A 3PHUA 1VJVA 1M6DA 1KFUL 1CB5A 2FRAA 2DCCA 3C9EA 2E03A 1Y4HA 2IPPB 2YJ9A 1AYVA 3O1GA 1KHQA 2P7UA 3K8UA 1EWPA 4WA6A 2FUDA 2H7JA 4QRVA 1NB3A 4RF0A 3U8EA 2FO5A 4K7CA 1THEA 3MHHA 2J7QA 4D8EA 1U5IA 3W30A 1NLJA 2G8EA 4YYRA 4I04A 2DJGB 2BTWB 2R9NA 2DC8A 3LFYA 1EWLA 1PE6A 2AGAA 3HHIA 9PAPA 1UKFA 2JQGR 4R3DA 2PBHA 4KLBA 2HWKA 5J94A 3MHSA 2AUZA 2R9OA 4A5UA 1ZIVA 3QSDA 1QXPA 2AU1A 1MS6A 3KWBX 1SNKA 1F2BA 2VHFA 1XKGA 3MTVA 3S3RA 4REZA 1BP4A 4N4ZA 7PCKA 1STFE 3K24A 3PT2A 2R9MA 3IEJA 3PHWA 2YJBA 2HH5A 3PW3A 3I3TA 1O0EA 4ZUXU 2DCBA 1YT7A 2B1MA 2NQDB 1MIRA 4X6HA 3CH2X 3TNXA 4HXDB 4BOQA 3IHPA 4QH6A 3PHXA 3F75A 4XZXA 5KO3A 3H8CA 3PNRA 2PREA 1MEMA 2JTCA 4BOZA 2G8JA 2DZYA 4QBBA 1PPPA 2J7QC 1POPA 2IBIA 3IMAA 3CH3X 1FH0A 3KW9A 4YYVA 2O6XA 2FE8A 2DC7A 2YJCA 4P6EA 3F5VA 4WURA 2DCAA 3PDFA 1U9QX 3AI8A 1CPJA 3NHEA 3BCNA 5EGWA 3GCBA 3N3GA 2BDLA 3MP2A 1Y08A 5K16A 4GUAA 4X6IA 6PADA 3QJ3A 3N4CA 3RVVA 4I05A 2WBFX 3V6CA 4OW0A 3BPMA 1PXVA 2DOSA 4N8WA 4MI7A 1AU4A 1NB5A 1AIMA 3H7DA 1YVBA 1DF0A 1PADA 1ITOA 3BWKA 3DF0A 3KSEA 3PRMA 2E01A 2ARYA 3PBHA 3P5VA 4YYUA 3PSEA 4PT5A 3RVXA 2XU4A 3OF8A 2NQGA 1CQDA 3BBAA 2GHUA 4BQVA 2YJ2A 2DCDA 3K9MA 1BQIA 1AU3A 4BOPA 4CDDB 4QRGA 3ZUAA 4BOUA 3E1ZB 5JZEA 4MM3B 1PVJA 2P86A 1TL9A 1AYWA 2VHSA 2F1GA 3MJ5A 3OF9A 4AXMA 5EZSA 2ATOA 1U9XA 5CVMA 1F2CA 3D6SA 4M0WA 3ZNHA 1NQCA 8PCHA 1PPOA 1EWOA 3P5UA 2BU3A 3HHAA 4IUMA 1JQPA 4P16A 3IFUA 5CVNB 1GLOA 3RVWA 1X9YA 3E9SA 5CVOB 2P0RA 3IUTA 3H89A 2CIOA 4G54A 1S4VA 3KX1A 4W4UA 2PNSA 1BGOA 4YYSA 2C0YA 2OZ2A 2DZZA 4XUIA 1DKIA 4BS6A 4YYWA 3ERVA 2Y5BA 2XU5A 4BSQA 3IV2A 4OELA 4YVAA 1YALA 1NL6A 4Q8GA 3TMPA 1F2AA 2JQFR 1GECE 4MZSA 4DMYA 1PPDA 4PP2E 1KFXL 3CBKA 5CHTA 2AIMA 2R9FA 5JA7A 1Q6KA 2UZJA 1VSNA 2AVWA 1BY8A 4FIPA 1EWMA 4RNAA 3LXSA 4OVZA 3BY4A 4Q8HA 2FQ9A 4MSXA 5E6JA 3BOWA 1GCBA 3MORA 1ME3A 3B79A 3IOQA 4MZOA 1AU0A 2NQIA 4DMXA 3HD3A 3P5WA 1MHWA 3PRPA 1GMYA 1MDWA 4N79A 4D8BA 2HD5A 2B1NA 3W31A 1IWDA 4I07A 1CJLA 4BPVA 4RY2A 2R9CA 2AS8A 3V6EA 5JH3A 2AYNA 1U9WA 2XU3A 1YK7A 4X6JA 2NQAA 1ME4A 1U9VA 1A6RA 2FT2A 2G6DA 2OP3A 3H6SA 1PIPA 4ZTBA 3BB7A 3TRKA 1EF7A 2G7YA 4BS5A 2Y6EA 4OVZB 1KHPA 4CDFB 2JRIA 3QT4A 1MEGA 2CB5A 3OISA 1YK8A 3USVA 2AUXA 4CZWA 4YYQA 5A24A 4HWYA 1KXRA 2DJFB 3B21A 3O65A 2BDZA 2XU1A 2Z84A 3N3KA 1CVZA 3WXFA 3S3QA 1K3BB 4PADA 1F29A 1HUCB 2YJ8A 4YV8A 3OVXA 5CHVA 1YZBA 1DEUA 2FRQA 4FJCA 3RNVA 3OQCA 1PBHA 1CSBB 5EZQA 3WXEA 1CV8A 1ICFA 5FPWA 1TU6A 2R6NA 4QRXA 1SP4B 4P6GA 3CBJA 2ACTA 3WXGA 1AU2A 2E00A 1ZCMA 3OVZA 1CTEA
chains in the Genus database with same CATH topology
1TLOA 2DC6A 2HXZA 4CDCB 1QOLA 3BPFA 4AXLA 5F02A 3MTNA 2FYEA 2E02A 2F7DA 3O0UA 1AYUA 4BGFA 1QDQA 2FTDA 1PCIA 2GFOA 1NPZA 3KFQA 4W5BA 5EF4A 3KKUA 3BC3A 5PADA 1AECA 4W5CA 4PI3A 2DC9A 1ATKA 2HHNA 3P5XA 1PPNA 4OEMA 2PADA 3I06A 2AYOA 3D9WA 3H8BA 4FK5A 2OULA 3KWZA 4XR7A 1QMYA 1CS8A 4C5PA 3HWNA 4PP1A 4CDEB 3M99A 1VJVA 1M6DA 1KFUL 1CB5A 2FRAA 2DCCA 3C9EA 2E03A 1Y4HA 2IPPB 2YJ9A 1AYVA 3O1GA 1KHQA 2P7UA 3K8UA 1EWPA 4WA6A 2FUDA 2H7JA 4QRVA 1NB3A 3U8EA 2FO5A 4K7CA 1THEA 3MHHA 1U5IA 1NLJA 2G8EA 4YYRA 4I04A 2DJGB 2R9NA 2DC8A 3LFYA 1EWLA 1PE6A 3HHIA 9PAPA 2JQGR 2PBHA 4KLBA 5J94A 3MHSA 2AUZA 2R9OA 3QSDA 1ZIVA 1QXPA 2AU1A 1MS6A 3KWBX 1SNKA 1F2BA 2VHFA 1XKGA 3S3RA 1BP4A 4N4ZA 7PCKA 1STFE 3K24A 2R9MA 3IEJA 2YJBA 2HH5A 3PW3A 3I3TA 1O0EA 4ZUXU 2DCBA 1YT7A 2B1MA 2NQDB 1MIRA 4X6HA 2VFCA 3CH2X 3TNXA 3IHPA 4QH6A 3F75A 3H8CA 3PNRA 2PREA 1MEMA 2G8JA 2DZYA 4QBBA 1PPPA 1POPA 2IBIA 3IMAA 3CH3X 1GX3A 4NV7A 2BSZA 1FH0A 3KW9A 4YYVA 2O6XA 2YJCA 2DC7A 4P6EA 3F5VA 2DCAA 3PDFA 1U9QX 3AI8A 1CPJA 3NHEA 3BCNA 5EGWA 3GCBA 3N3GA 1E2TA 2BDLA 1Y08A 5K16A 4X6IA 6PADA 3QJ3A 3N4CA 3RVVA 4I05A 2WBFX 3LTWA 3V6CA 3BPMA 1PXVA 4N8WA 1W5RA 1AU4A 1NB5A 1AIMA 3H7DA 1YVBA 1DF0A 1PADA 1ITOA 3BWKA 3DF0A 3KSEA 2E01A 2ARYA 3PBHA 3P5VA 4YYUA 3RVXA 2XU4A 3OF8A 2VFBA 2NQGA 1CQDA 2GHUA 4BQVA 2YJ2A 2DCDA 3K9MA 1BQIA 1AU3A 4CDDB 4QRGA 3ZUAA 3E1ZB 2P86A 1TL9A 1AYWA 2VHSA 2F1GA 3OF9A 4AXMA 2ATOA 1U9XA 5CVMA 1F2CA 3D6SA 1NQCA 8PCHA 1PPOA 1EWOA 3P5UA 3HHAA 1JQPA 5CVNB 1GLOA 3RVWA 1X9YA 5CVOB 2P0RA 3IUTA 3H89A 4G54A 2CIOA 1S4VA 3KX1A 4W4UA 2PNSA 1BGOA 4YYSA 2C0YA 2OZ2A 2DZZA 4XUIA 4BS6A 4YYWA 3ERVA 2Y5BA 2XU5A 4BSQA 3IV2A 4OELA 4YVAA 1YALA 1NL6A 4Q8GA 1F2AA 2JQFR 1GECE 4MZSA 4DMYA 1PPDA 4PP2E 1KFXL 3CBKA 5CHTA 2AIMA 2R9FA 5JA7A 1Q6KA 1VSNA 2AVWA 1BY8A 4FIPA 1EWMA 3LXSA 4Q8HA 2FQ9A 4MSXA 3BOWA 1GCBA 3MORA 1ME3A 4NV8A 3B79A 3IOQA 4MZOA 1AU0A 2NQIA 4DMXA 3HD3A 3P5WA 1MHWA 1GMYA 1MDWA 4N79A 2HD5A 2B1NA 1IWDA 4I07A 1CJLA 4BPVA 4RY2A 2R9CA 2AS8A 3V6EA 5JH3A 2AYNA 1U9WA 2XU3A 1YK7A 4X6JA 2NQAA 1W4TA 1ME4A 1U9VA 1A6RA 2FT2A 2G6DA 2OP3A 4B55A 3H6SA 1PIPA 1EF7A 2G7YA 4BS5A 2Y6EA 1KHPA 4CDFB 3QT4A 1MEGA 2CB5A 3OISA 1YK8A 3USVA 2AUXA 4CZWA 4YYQA 5A24A 4HWYA 1KXRA 2DJFB 2BDZA 2XU1A 3N3KA 1CVZA 3WXFA 3S3QA 1K3BB 4PADA 1F29A 1HUCB 1W6FA 2YJ8A 4YV8A 3OVXA 5CHVA 1DEUA 2FRQA 4FJCA 1PBHA 1CSBB 3WXEA 1CV8A 1ICFA 5FPWA 1TU6A 2R6NA 4QRXA 1SP4B 4P6GA 3CBJA 2ACTA 3WXGA 1AU2A 2E00A 1ZCMA 4GUZA 3OVZA 1CTEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TLO A;  2DC6 A;  2HXZ A;  4CDC B;  1QOL A;  3BPF A;  4AXL A;  5F02 A;  3MTN A;  2FYE A;  2E02 A;  2F7D A;  3O0U A;  1AYU A;  1QDQ A;  2FTD A;  1PCI A;  2GFO A;  1NPZ A;  3KFQ A;  4W5B A;  5EF4 A;  3KKU A;  3BC3 A;  5PAD A;  1AEC A;  4W5C A;  4PI3 A;  2DC9 A;  1ATK A;  2HHN A;  3P5X A;  1PPN A;  4OEM A;  2PAD A;  3I06 A;  2AYO A;  3H8B A;  4FK5 A;  2OUL A;  3KWZ A;  4XR7 A;  1QMY A;  1CS8 A;  3HWN A;  4PP1 A;  4CDE B;  3M99 A;  1VJV A;  1M6D A;  1KFU L;  1CB5 A;  2FRA A;  2DCC A;  3C9E A;  2E03 A;  1Y4H A;  2IPP B;  2YJ9 A;  1AYV A;  3O1G A;  1KHQ A;  2P7U A;  3K8U A;  1EWP A;  4WA6 A;  2FUD A;  2H7J A;  4QRV A;  1NB3 A;  3U8E A;  2FO5 A;  4K7C A;  1THE A;  3MHH A;  1U5I A;  1NLJ A;  2G8E A;  4YYR A;  4I04 A;  2DJG B;  2R9N A;  2DC8 A;  3LFY A;  1EWL A;  1PE6 A;  3HHI A;  9PAP A;  2JQG R;  2PBH A;  4KLB A;  5J94 A;  3MHS A;  2AUZ A;  2R9O A;  3QSD A;  1ZIV A;  1QXP A;  2AU1 A;  1MS6 A;  3KWB X;  1SNK A;  1F2B A;  2VHF A;  1XKG A;  3S3R A;  1BP4 A;  4N4Z A;  7PCK A;  1STF E;  3K24 A;  2R9M A;  3IEJ A;  2YJB A;  2HH5 A;  3PW3 A;  3I3T A;  1O0E A;  4ZUX U;  2DCB A;  1YT7 A;  2B1M A;  2NQD B;  1MIR A;  4X6H A;  3CH2 X;  3TNX A;  3IHP A;  4QH6 A;  3F75 A;  3H8C A;  3PNR A;  2PRE A;  1MEM A;  2G8J A;  2DZY A;  4QBB A;  1PPP A;  1POP A;  2IBI A;  3IMA A;  3CH3 X;  1FH0 A;  3KW9 A;  4YYV A;  2O6X A;  2YJC A;  2DC7 A;  4P6E A;  3F5V A;  2DCA A;  3PDF A;  1U9Q X;  3AI8 A;  1CPJ A;  3NHE A;  3BCN A;  5EGW A;  3GCB A;  3N3G A;  2BDL A;  1Y08 A;  5K16 A;  4X6I A;  6PAD A;  3QJ3 A;  3N4C A;  3RVV A;  4I05 A;  2WBF X;  3V6C A;  3BPM A;  1PXV A;  4N8W A;  1AU4 A;  1NB5 A;  1AIM A;  3H7D A;  1YVB A;  1DF0 A;  1PAD A;  1ITO A;  3BWK A;  3DF0 A;  3KSE A;  2E01 A;  2ARY A;  3PBH A;  3P5V A;  4YYU A;  3RVX A;  2XU4 A;  3OF8 A;  2NQG A;  1CQD A;  2GHU A;  4BQV A;  2YJ2 A;  2DCD A;  3K9M A;  1BQI A;  1AU3 A;  4CDD B;  4QRG A;  3ZUA A;  3E1Z B;  2P86 A;  1TL9 A;  1AYW A;  2VHS A;  2F1G A;  3OF9 A;  4AXM A;  2ATO A;  1U9X A;  5CVM A;  1F2C A;  3D6S A;  1NQC A;  8PCH A;  1PPO A;  1EWO A;  3P5U A;  3HHA A;  1JQP A;  5CVN B;  1GLO A;  3RVW A;  1X9Y A;  5CVO B;  2P0R A;  3IUT A;  3H89 A;  4G54 A;  2CIO A;  1S4V A;  3KX1 A;  4W4U A;  2PNS A;  1BGO A;  4YYS A;  2C0Y A;  2OZ2 A;  2DZZ A;  4XUI A;  4BS6 A;  4YYW A;  3ERV A;  2Y5B A;  2XU5 A;  4BSQ A;  3IV2 A;  4OEL A;  4YVA A;  1YAL A;  1NL6 A;  4Q8G A;  1F2A A;  2JQF R;  1GEC E;  4MZS A;  4DMY A;  1PPD A;  4PP2 E;  1KFX L;  3CBK A;  5CHT A;  2AIM A;  2R9F A;  5JA7 A;  1Q6K A;  1VSN A;  2AVW A;  1BY8 A;  4FIP A;  1EWM A;  3LXS A;  4Q8H A;  2FQ9 A;  4MSX A;  3BOW A;  1GCB A;  3MOR A;  1ME3 A;  3B79 A;  3IOQ A;  4MZO A;  1AU0 A;  2NQI A;  4DMX A;  3HD3 A;  3P5W A;  1MHW A;  1GMY A;  1MDW A;  4N79 A;  2HD5 A;  2B1N A;  1IWD A;  4I07 A;  1CJL A;  4BPV A;  4RY2 A;  2R9C A;  2AS8 A;  3V6E A;  5JH3 A;  2AYN A;  1U9W A;  2XU3 A;  1YK7 A;  4X6J A;  2NQA A;  1ME4 A;  1U9V A;  1A6R A;  2FT2 A;  2G6D A;  2OP3 A;  3H6S A;  1PIP A;  1EF7 A;  2G7Y A;  4BS5 A;  2Y6E A;  1KHP A;  4CDF B;  3QT4 A;  1MEG A;  2CB5 A;  3OIS A;  1YK8 A;  3USV A;  2AUX A;  4CZW A;  4YYQ A;  5A24 A;  4HWY A;  1KXR A;  2DJF B;  2BDZ A;  2XU1 A;  3N3K A;  1CVZ A;  3WXF A;  3S3Q A;  1K3B B;  4PAD A;  1F29 A;  1HUC B;  2YJ8 A;  4YV8 A;  3OVX A;  5CHV A;  1DEU A;  2FRQ A;  4FJC A;  1PBH A;  1CSB B;  3WXE A;  1CV8 A;  1ICF A;  5FPW A;  1TU6 A;  2R6N A;  4QRX A;  1SP4 B;  4P6G A;  3CBJ A;  2ACT A;  3WXG A;  1AU2 A;  2E00 A;  1ZCM A;  3OVZ A;  1CTE A; 
#chains in the Genus database with same CATH topology
 1TLO A;  2DC6 A;  2HXZ A;  4CDC B;  1QOL A;  3BPF A;  4AXL A;  5F02 A;  3MTN A;  4IP3 A;  2FYE A;  2E02 A;  2F7D A;  3O0U A;  1AYU A;  4BOS A;  1QDQ A;  2FTD A;  1PCI A;  2GFO A;  1NPZ A;  3KFQ A;  4W5B A;  5EF4 A;  3KKU A;  3BC3 A;  5PAD A;  1AEC A;  4W5C A;  4PI3 A;  2DC9 A;  1ATK A;  2HHN A;  3P5X A;  1PPN A;  4OEM A;  2PAD A;  3I06 A;  2AYO A;  3C0R A;  3H8B A;  4FK5 A;  4RF1 A;  2OUL A;  2BTW A;  3KWZ A;  4XR7 A;  1QMY A;  1CS8 A;  3HWN A;  4D8I A;  4PP1 A;  4CDE B;  4RKX A;  3M99 A;  3PHU A;  1VJV A;  1M6D A;  1KFU L;  1CB5 A;  2FRA A;  2DCC A;  3C9E A;  2E03 A;  1Y4H A;  2IPP B;  2YJ9 A;  1AYV A;  3O1G A;  1KHQ A;  2P7U A;  3K8U A;  1EWP A;  4WA6 A;  2FUD A;  2H7J A;  4QRV A;  1NB3 A;  4RF0 A;  3U8E A;  2FO5 A;  4K7C A;  1THE A;  3MHH A;  2J7Q A;  4D8E A;  1U5I A;  3W30 A;  1NLJ A;  2G8E A;  4YYR A;  4I04 A;  2DJG B;  2BTW B;  2R9N A;  2DC8 A;  3LFY A;  1EWL A;  1PE6 A;  2AGA A;  3HHI A;  9PAP A;  1UKF A;  2JQG R;  4R3D A;  2PBH A;  4KLB A;  2HWK A;  5J94 A;  3MHS A;  2AUZ A;  2R9O A;  4A5U A;  1ZIV A;  3QSD A;  1QXP A;  2AU1 A;  1MS6 A;  3KWB X;  1SNK A;  1F2B A;  2VHF A;  1XKG A;  3MTV A;  3S3R A;  4REZ A;  1BP4 A;  4N4Z A;  7PCK A;  1STF E;  3K24 A;  3PT2 A;  2R9M A;  3IEJ A;  3PHW A;  2YJB A;  2HH5 A;  3PW3 A;  3I3T A;  1O0E A;  4ZUX U;  2DCB A;  1YT7 A;  2B1M A;  2NQD B;  1MIR A;  4X6H A;  3CH2 X;  3TNX A;  4HXD B;  4BOQ A;  3IHP A;  4QH6 A;  3PHX A;  3F75 A;  4XZX A;  5KO3 A;  3H8C A;  3PNR A;  2PRE A;  1MEM A;  2JTC A;  4BOZ A;  2G8J A;  2DZY A;  4QBB A;  1PPP A;  2J7Q C;  1POP A;  2IBI A;  3IMA A;  3CH3 X;  1FH0 A;  3KW9 A;  4YYV A;  2O6X A;  2FE8 A;  2DC7 A;  2YJC A;  4P6E A;  3F5V A;  4WUR A;  2DCA A;  3PDF A;  1U9Q X;  3AI8 A;  1CPJ A;  3NHE A;  3BCN A;  5EGW A;  3GCB A;  3N3G A;  2BDL A;  3MP2 A;  1Y08 A;  5K16 A;  4GUA A;  4X6I A;  6PAD A;  3QJ3 A;  3N4C A;  3RVV A;  4I05 A;  2WBF X;  3V6C A;  4OW0 A;  3BPM A;  1PXV A;  2DOS A;  4N8W A;  4MI7 A;  1AU4 A;  1NB5 A;  1AIM A;  3H7D A;  1YVB A;  1DF0 A;  1PAD A;  1ITO A;  3BWK A;  3DF0 A;  3KSE A;  3PRM A;  2E01 A;  2ARY A;  3PBH A;  3P5V A;  4YYU A;  3PSE A;  4PT5 A;  3RVX A;  2XU4 A;  3OF8 A;  2NQG A;  1CQD A;  3BBA A;  2GHU A;  4BQV A;  2YJ2 A;  2DCD A;  3K9M A;  1BQI A;  1AU3 A;  4BOP A;  4CDD B;  4QRG A;  3ZUA A;  4BOU A;  3E1Z B;  5JZE A;  4MM3 B;  1PVJ A;  2P86 A;  1TL9 A;  1AYW A;  2VHS A;  2F1G A;  3MJ5 A;  3OF9 A;  4AXM A;  5EZS A;  2ATO A;  1U9X A;  5CVM A;  1F2C A;  3D6S A;  4M0W A;  3ZNH A;  1NQC A;  8PCH A;  1PPO A;  1EWO A;  3P5U A;  2BU3 A;  3HHA A;  4IUM A;  1JQP A;  4P16 A;  3IFU A;  5CVN B;  1GLO A;  3RVW A;  1X9Y A;  3E9S A;  5CVO B;  2P0R A;  3IUT A;  3H89 A;  2CIO A;  4G54 A;  1S4V A;  3KX1 A;  4W4U A;  2PNS A;  1BGO A;  4YYS A;  2C0Y A;  2OZ2 A;  2DZZ A;  4XUI A;  1DKI A;  4BS6 A;  4YYW A;  3ERV A;  2Y5B A;  2XU5 A;  4BSQ A;  3IV2 A;  4OEL A;  4YVA A;  1YAL A;  1NL6 A;  4Q8G A;  3TMP A;  1F2A A;  2JQF R;  1GEC E;  4MZS A;  4DMY A;  1PPD A;  4PP2 E;  1KFX L;  3CBK A;  5CHT A;  2AIM A;  2R9F A;  5JA7 A;  1Q6K A;  2UZJ A;  1VSN A;  2AVW A;  1BY8 A;  4FIP A;  1EWM A;  4RNA A;  3LXS A;  4OVZ A;  3BY4 A;  4Q8H A;  2FQ9 A;  4MSX A;  5E6J A;  3BOW A;  1GCB A;  3MOR A;  1ME3 A;  3B79 A;  3IOQ A;  4MZO A;  1AU0 A;  2NQI A;  4DMX A;  3HD3 A;  3P5W A;  1MHW A;  3PRP A;  1GMY A;  1MDW A;  4N79 A;  4D8B A;  2HD5 A;  2B1N A;  3W31 A;  1IWD A;  4I07 A;  1CJL A;  4BPV A;  4RY2 A;  2R9C A;  2AS8 A;  3V6E A;  5JH3 A;  2AYN A;  1U9W A;  2XU3 A;  1YK7 A;  4X6J A;  2NQA A;  1ME4 A;  1U9V A;  1A6R A;  2FT2 A;  2G6D A;  2OP3 A;  3H6S A;  1PIP A;  4ZTB A;  3BB7 A;  3TRK A;  1EF7 A;  2G7Y A;  4BS5 A;  2Y6E A;  4OVZ B;  1KHP A;  4CDF B;  2JRI A;  3QT4 A;  1MEG A;  2CB5 A;  3OIS A;  1YK8 A;  3USV A;  2AUX A;  4CZW A;  4YYQ A;  5A24 A;  4HWY A;  1KXR A;  2DJF B;  3B21 A;  3O65 A;  2BDZ A;  2XU1 A;  2Z84 A;  3N3K A;  1CVZ A;  3WXF A;  3S3Q A;  1K3B B;  4PAD A;  1F29 A;  1HUC B;  2YJ8 A;  4YV8 A;  3OVX A;  5CHV A;  1YZB A;  1DEU A;  2FRQ A;  4FJC A;  3RNV A;  3OQC A;  1PBH A;  1CSB B;  5EZQ A;  3WXE A;  1CV8 A;  1ICF A;  5FPW A;  1TU6 A;  2R6N A;  4QRX A;  1SP4 B;  4P6G A;  3CBJ A;  2ACT A;  3WXG A;  1AU2 A;  2E00 A;  1ZCM A;  3OVZ A;  1CTE A; 
#chains in the Genus database with same CATH homology
 1TLO A;  2DC6 A;  2HXZ A;  4CDC B;  1QOL A;  3BPF A;  4AXL A;  5F02 A;  3MTN A;  2FYE A;  2E02 A;  2F7D A;  3O0U A;  1AYU A;  4BGF A;  1QDQ A;  2FTD A;  1PCI A;  2GFO A;  1NPZ A;  3KFQ A;  4W5B A;  5EF4 A;  3KKU A;  3BC3 A;  5PAD A;  1AEC A;  4W5C A;  4PI3 A;  2DC9 A;  1ATK A;  2HHN A;  3P5X A;  1PPN A;  4OEM A;  2PAD A;  3I06 A;  2AYO A;  3D9W A;  3H8B A;  4FK5 A;  2OUL A;  3KWZ A;  4XR7 A;  1QMY A;  1CS8 A;  4C5P A;  3HWN A;  4PP1 A;  4CDE B;  3M99 A;  1VJV A;  1M6D A;  1KFU L;  1CB5 A;  2FRA A;  2DCC A;  3C9E A;  2E03 A;  1Y4H A;  2IPP B;  2YJ9 A;  1AYV A;  3O1G A;  1KHQ A;  2P7U A;  3K8U A;  1EWP A;  4WA6 A;  2FUD A;  2H7J A;  4QRV A;  1NB3 A;  3U8E A;  2FO5 A;  4K7C A;  1THE A;  3MHH A;  1U5I A;  1NLJ A;  2G8E A;  4YYR A;  4I04 A;  2DJG B;  2R9N A;  2DC8 A;  3LFY A;  1EWL A;  1PE6 A;  3HHI A;  9PAP A;  2JQG R;  2PBH A;  4KLB A;  5J94 A;  3MHS A;  2AUZ A;  2R9O A;  3QSD A;  1ZIV A;  1QXP A;  2AU1 A;  1MS6 A;  3KWB X;  1SNK A;  1F2B A;  2VHF A;  1XKG A;  3S3R A;  1BP4 A;  4N4Z A;  7PCK A;  1STF E;  3K24 A;  2R9M A;  3IEJ A;  2YJB A;  2HH5 A;  3PW3 A;  3I3T A;  1O0E A;  4ZUX U;  2DCB A;  1YT7 A;  2B1M A;  2NQD B;  1MIR A;  4X6H A;  2VFC A;  3CH2 X;  3TNX A;  3IHP A;  4QH6 A;  3F75 A;  3H8C A;  3PNR A;  2PRE A;  1MEM A;  2G8J A;  2DZY A;  4QBB A;  1PPP A;  1POP A;  2IBI A;  3IMA A;  3CH3 X;  1GX3 A;  4NV7 A;  2BSZ A;  1FH0 A;  3KW9 A;  4YYV A;  2O6X A;  2YJC A;  2DC7 A;  4P6E A;  3F5V A;  2DCA A;  3PDF A;  1U9Q X;  3AI8 A;  1CPJ A;  3NHE A;  3BCN A;  5EGW A;  3GCB A;  3N3G A;  1E2T A;  2BDL A;  1Y08 A;  5K16 A;  4X6I A;  6PAD A;  3QJ3 A;  3N4C A;  3RVV A;  4I05 A;  2WBF X;  3LTW A;  3V6C A;  3BPM A;  1PXV A;  4N8W A;  1W5R A;  1AU4 A;  1NB5 A;  1AIM A;  3H7D A;  1YVB A;  1DF0 A;  1PAD A;  1ITO A;  3BWK A;  3DF0 A;  3KSE A;  2E01 A;  2ARY A;  3PBH A;  3P5V A;  4YYU A;  3RVX A;  2XU4 A;  3OF8 A;  2VFB A;  2NQG A;  1CQD A;  2GHU A;  4BQV A;  2YJ2 A;  2DCD A;  3K9M A;  1BQI A;  1AU3 A;  4CDD B;  4QRG A;  3ZUA A;  3E1Z B;  2P86 A;  1TL9 A;  1AYW A;  2VHS A;  2F1G A;  3OF9 A;  4AXM A;  2ATO A;  1U9X A;  5CVM A;  1F2C A;  3D6S A;  1NQC A;  8PCH A;  1PPO A;  1EWO A;  3P5U A;  3HHA A;  1JQP A;  5CVN B;  1GLO A;  3RVW A;  1X9Y A;  5CVO B;  2P0R A;  3IUT A;  3H89 A;  4G54 A;  2CIO A;  1S4V A;  3KX1 A;  4W4U A;  2PNS A;  1BGO A;  4YYS A;  2C0Y A;  2OZ2 A;  2DZZ A;  4XUI A;  4BS6 A;  4YYW A;  3ERV A;  2Y5B A;  2XU5 A;  4BSQ A;  3IV2 A;  4OEL A;  4YVA A;  1YAL A;  1NL6 A;  4Q8G A;  1F2A A;  2JQF R;  1GEC E;  4MZS A;  4DMY A;  1PPD A;  4PP2 E;  1KFX L;  3CBK A;  5CHT A;  2AIM A;  2R9F A;  5JA7 A;  1Q6K A;  1VSN A;  2AVW A;  1BY8 A;  4FIP A;  1EWM A;  3LXS A;  4Q8H A;  2FQ9 A;  4MSX A;  3BOW A;  1GCB A;  3MOR A;  1ME3 A;  4NV8 A;  3B79 A;  3IOQ A;  4MZO A;  1AU0 A;  2NQI A;  4DMX A;  3HD3 A;  3P5W A;  1MHW A;  1GMY A;  1MDW A;  4N79 A;  2HD5 A;  2B1N A;  1IWD A;  4I07 A;  1CJL A;  4BPV A;  4RY2 A;  2R9C A;  2AS8 A;  3V6E A;  5JH3 A;  2AYN A;  1U9W A;  2XU3 A;  1YK7 A;  4X6J A;  2NQA A;  1W4T A;  1ME4 A;  1U9V A;  1A6R A;  2FT2 A;  2G6D A;  2OP3 A;  4B55 A;  3H6S A;  1PIP A;  1EF7 A;  2G7Y A;  4BS5 A;  2Y6E A;  1KHP A;  4CDF B;  3QT4 A;  1MEG A;  2CB5 A;  3OIS A;  1YK8 A;  3USV A;  2AUX A;  4CZW A;  4YYQ A;  5A24 A;  4HWY A;  1KXR A;  2DJF B;  2BDZ A;  2XU1 A;  3N3K A;  1CVZ A;  3WXF A;  3S3Q A;  1K3B B;  4PAD A;  1F29 A;  1HUC B;  1W6F A;  2YJ8 A;  4YV8 A;  3OVX A;  5CHV A;  1DEU A;  2FRQ A;  4FJC A;  1PBH A;  1CSB B;  3WXE A;  1CV8 A;  1ICF A;  5FPW A;  1TU6 A;  2R6N A;  4QRX A;  1SP4 B;  4P6G A;  3CBJ A;  2ACT A;  3WXG A;  1AU2 A;  2E00 A;  1ZCM A;  4GUZ A;  3OVZ A;  1CTE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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