2DC9A

X-ray crystal structure analysis of bovine spleen cathepsin b-ca074me complex
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
253
structure length
251
Chain Sequence
LPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes
rcsb
molecule tags Hydrolase
molecule keywords CATHEPSIN B
total genus 78
structure length 251
sequence length 253
ec nomenclature ec 3.4.22.1: Cathepsin B.
pdb deposition date 2005-12-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 2dc9A00
5CVNB 2JQGR 5FPWA 4CDEB 3N4CA 1PXVA 3F75A 3H89A 1ITOA 2DCAA 3RVVA 3IHPA 1SNKA 3DF0A 1FH0A 3KWZA 1TLOA 1KHPA 3PW3A 4MSXA 4QRGA 2AU1A 3M99A 2CB5A 3I06A 2F1GA 1F2CA 5EGWA 2R9OA 1YK7A 1Q6KA 3MHSA 3IOQA 4W5CA 2R9FA 2DZZA 2AVWA 2Y6EA 4X6JA 1M6DA 2B1NA 2VHFA 1NB5A 5EF4A 2AUZA 2E00A 4PP1A 2NQIA 3OF9A 1KFXL 1YALA 4XR7A 2HH5A 2P7UA 3RVWA 1K3BB 3I3TA 1PPPA 1MIRA 1CS8A 8PCHA 1Y4HA 2YJCA 4YV8A 3PDFA 1MEMA 1GECE 3QT4A 1NLJA 4I05A 4CDDB 1PIPA 2NQDB 2R9CA 1CV8A 4OEMA 1STFE 4FJCA 4YYRA 3OISA 1U9QX 4BSQA 3P5VA 1NL6A 1SP4B 2G7YA 3IV2A 1S4VA 1BY8A 2AUXA 2H7JA 2R9NA 3F5VA 4FK5A 4K7CA 3H7DA 3CBKA 3QJ3A 1ME4A 1YK8A 1GMYA 1PPNA 4X6HA 3K8UA 3GCBA 3IMAA 4BS5A 4YYSA 2GFOA 2DC8A 2ARYA 1U9XA 2YJBA 5JH3A 4YYUA 1THEA 1X9YA 1AU4A 1F29A 1AYUA 4W5BA 1POPA 4CDCB 4QRVA 2C0YA 1TL9A 1HUCB 1Y08A 2R6NA 1QXPA 3OVXA 1F2AA 3KWBX 1MS6A 3O1GA 3V6EA 2DC9A 1AU2A 2HD5A 3O0UA 5A24A 3WXEA 3BOWA 2O6XA 3NHEA 1QMYA 1TU6A 4N4ZA 2OZ2A 4PADA 3AI8A 3USVA 4XUIA 4P6EA 1AYWA 1NPZA 4P6GA 3S3RA 3K24A 1MHWA 3P5WA 2AYOA 7PCKA 1VSNA 1QDQA 1GCBA 3KKUA 2G6DA 1NB3A 2NQGA 3E1ZB 3PNRA 2HHNA 1GLOA 4HWYA 3TNXA 2FTDA 4QBBA 4BS6A 1VJVA 4KLBA 3N3GA 4CZWA 1CB5A 1ZCMA 2VHSA 2FUDA 3KFQA 3ZUAA 4AXLA 3B79A 1CQDA 1ICFA 1F2BA 1XKGA 1PPOA 1PCIA 4YVAA 2HXZA 4DMYA 1AECA 4PP2E 3KW9A 3MTNA 5JA7A 3V6CA 1U9VA 1U9WA 3IUTA 4BPVA 2FRAA 4DMXA 1PBHA 4QH6A 4W4UA 2G8JA 2FO5A 1MEGA 5F02A 4PI3A 3LXSA 2AIMA 2AS8A 3S3QA 1CPJA 5J94A 2DC7A 4WA6A 3K9MA 2IPPB 4OELA 2R9MA 2DC6A 3WXGA 3CH2X 1MDWA 3IEJA 1AIMA 2P86A 2YJ2A 2PBHA 4G54A 3N3KA 3U8EA 1ZIVA 4YYWA 3LFYA 1EWMA 3H8BA 2DCDA 1EWPA 1KXRA 2DZYA 2FRQA 1JQPA 3HHIA 4MZSA 3ERVA 3HD3A 1DEUA 3CBJA 1AU3A 1A6RA 2B1MA 2PADA 2XU3A 2Y5BA 1O0EA 2FT2A 3BPFA 2OP3A 5CVMA 1PPDA 2DJGB 2AYNA 2FQ9A 5CHTA 9PAPA 1KFUL 1AU0A 2YJ8A 2G8EA 2XU1A 2ACTA 4N8WA 4Q8GA 1BP4A 3OVZA 4FIPA 2CIOA 2GHUA 2BDLA 1CVZA 3P5UA 3MORA 2PREA 3BC3A 3H8CA 2DJFB 3BWKA 4BQVA 5CVOB 1PADA 2DCBA 4YYVA 1IWDA 5CHVA 4ZUXU 1ME3A 2WBFX 3C9EA 2E02A 2IBIA 3HWNA 3MHHA 6PADA 2FYEA 3HHAA 2F7DA 4I07A 2YJ9A 3WXFA 4RY2A 5K16A 1U5IA 3KSEA 4YYQA 2XU4A 5PADA 1NQCA 2PNSA 3P5XA 4AXMA 2BDZA 1KHQA 3BPMA 4QRXA 2P0RA 1AYVA 1PE6A 1YT7A 2DCCA 4MZOA 1YVBA 3BCNA 2E01A 1BQIA 3KX1A 4N79A 2E03A 2JQFR 3OF8A 4X6IA 3QSDA 3CH3X 1EF7A 1EWLA 1ATKA 2ATOA 1CSBB 4Q8HA 3D6SA 4CDFB 1CJLA 1BGOA 2OULA 1EWOA 4I04A 3RVXA 1DF0A 3PBHA 2XU5A 2NQAA 1QOLA 3H6SA 1CTEA
chains in the Genus database with same CATH superfamily
5CVNB 2JQGR 5FPWA 4CDEB 3N4CA 4RKXA 4REZA 1PXVA 3F75A 3H89A 1ITOA 2DCAA 3RVVA 3IHPA 1SNKA 3DF0A 1FH0A 3KWZA 1TLOA 1KHPA 3PW3A 4MSXA 4QRGA 2AU1A 3M99A 2CB5A 3I06A 2F1GA 4BOUA 1F2CA 3IFUA 5EGWA 2R9OA 1YK7A 1Q6KA 3MHSA 2JRIA 5JZEA 3PSEA 3IOQA 4W5CA 3TRKA 2R9FA 2DZZA 2AVWA 2Y6EA 4X6JA 4P16A 1M6DA 2B1NA 2UZJA 2VHFA 1NB5A 5EF4A 2AUZA 2E00A 4PP1A 2NQIA 3OF9A 1KFXL 1YALA 3MP2A 4XR7A 2HH5A 2P7UA 3RVWA 1K3BB 3I3TA 1PPPA 5E6JA 2BU3A 2DOSA 1MIRA 1CS8A 8PCHA 1Y4HA 2YJCA 4YV8A 3PDFA 1MEMA 1GECE 3QT4A 1NLJA 4I05A 4CDDB 1DKIA 1PIPA 2NQDB 2R9CA 4D8EA 1CV8A 4OEMA 2AGAA 1STFE 4FJCA 4YYRA 3OISA 2HWKA 1U9QX 4BSQA 3P5VA 1NL6A 1SP4B 2G7YA 3IV2A 4WURA 1S4VA 3PRMA 1BY8A 2AUXA 2H7JA 2R9NA 4PT5A 4RNAA 3F5VA 4FK5A 4K7CA 3H7DA 3CBKA 3QJ3A 1ME4A 1YK8A 1GMYA 1PPNA 4X6HA 3K8UA 1YZBA 2J7QA 5EZSA 3GCBA 3IMAA 4BOSA 4BS5A 4YYSA 2GFOA 2DC8A 2ARYA 1U9XA 2YJBA 5JH3A 4YYUA 1THEA 4D8IA 1X9YA 1AU4A 1F29A 1AYUA 4W5BA 1POPA 4CDCB 4QRVA 2C0YA 1TL9A 4IP3A 1HUCB 1Y08A 2R6NA 1QXPA 3OVXA 1F2AA 3KWBX 4OVZA 1MS6A 3O1GA 3V6EA 2DC9A 4XZXA 1AU2A 2HD5A 3O0UA 5A24A 3WXEA 4OVZB 3BOWA 2O6XA 3NHEA 1QMYA 1TU6A 4N4ZA 3W31A 2OZ2A 3BBAA 3ZNHA 4PADA 3AI8A 3OQCA 3USVA 2JTCA 4XUIA 4P6EA 1AYWA 1NPZA 4P6GA 3MTVA 3S3RA 3K24A 1MHWA 3P5WA 3MJ5A 3BY4A 2AYOA 7PCKA 1VSNA 1QDQA 1GCBA 3KKUA 2G6DA 4OW0A 1NB3A 2NQGA 4RF1A 3E1ZB 3PNRA 2HHNA 1GLOA 4HWYA 3TNXA 2FTDA 4QBBA 4BS6A 1VJVA 4KLBA 4D8BA 3N3GA 2FE8A 4CZWA 1CB5A 1ZCMA 2VHSA 2FUDA 3KFQA 3ZUAA 4AXLA 1UKFA 3B79A 1CQDA 4GUAA 1ICFA 1F2BA 1XKGA 1PPOA 1PCIA 4YVAA 2HXZA 4DMYA 1AECA 3E9SA 4PP2E 3KW9A 3MTNA 5JA7A 3V6CA 1U9VA 1U9WA 3IUTA 4BPVA 2FRAA 4DMXA 1PBHA 4QH6A 4W4UA 2G8JA 2FO5A 1MEGA 5F02A 4PI3A 4HXDB 3LXSA 2AIMA 2AS8A 3S3QA 1CPJA 5J94A 3C0RA 4ZTBA 2DC7A 1PVJA 4WA6A 3K9MA 2IPPB 4OELA 2R9MA 2DC6A 3WXGA 3O65A 3CH2X 1MDWA 3IEJA 1AIMA 2BTWB 2P86A 2YJ2A 2PBHA 4G54A 3N3KA 3U8EA 1ZIVA 4YYWA 3LFYA 5EZQA 1EWMA 3H8BA 2DCDA 1EWPA 3B21A 1KXRA 2DZYA 2FRQA 1JQPA 3HHIA 4MZSA 3ERVA 3HD3A 1DEUA 3CBJA 1AU3A 1A6RA 2B1MA 2PADA 2XU3A 2Y5BA 1O0EA 3BB7A 2FT2A 4R3DA 3BPFA 4RF0A 2OP3A 5CVMA 1PPDA 2DJGB 2AYNA 2FQ9A 4BOPA 5CHTA 9PAPA 1KFUL 4BOQA 1AU0A 2YJ8A 2G8EA 2XU1A 2ACTA 4N8WA 4Q8GA 1BP4A 3OVZA 4FIPA 2CIOA 2GHUA 2BDLA 1CVZA 3P5UA 3MORA 2PREA 3BC3A 5KO3A 3H8CA 2DJFB 3BWKA 4M0WA 4BQVA 5CVOB 1PADA 3W30A 2DCBA 4YYVA 1IWDA 5CHVA 4ZUXU 2J7QC 1ME3A 2WBFX 3C9EA 2E02A 2IBIA 3HWNA 3MHHA 6PADA 2FYEA 3TMPA 3HHAA 2F7DA 4IUMA 4BOZA 4I07A 4A5UA 4MM3B 2YJ9A 3WXFA 4RY2A 4MI7A 3PHUA 5K16A 3PHXA 1U5IA 3KSEA 4YYQA 2XU4A 5PADA 1NQCA 2PNSA 3PHWA 3P5XA 4AXMA 2BDZA 1KHQA 3PRPA 3BPMA 4QRXA 2P0RA 1AYVA 1PE6A 1YT7A 2DCCA 4MZOA 2BTWA 1YVBA 3BCNA 3PT2A 2E01A 1BQIA 3KX1A 4N79A 2E03A 2JQFR 3OF8A 4X6IA 3QSDA 3CH3X 1EF7A 1EWLA 1ATKA 3RNVA 2ATOA 1CSBB 4Q8HA 3D6SA 4CDFB 2Z84A 1CJLA 1BGOA 2OULA 1EWOA 4I04A 3RVXA 1DF0A 3PBHA 2XU5A 2NQAA 1QOLA 3H6SA 1CTEA
chains in the Genus database with same CATH topology
5CVNB 2JQGR 5FPWA 4CDEB 3N4CA 1PXVA 3F75A 3H89A 1ITOA 2DCAA 3RVVA 3IHPA 1SNKA 3DF0A 1FH0A 3KWZA 1TLOA 1KHPA 3PW3A 4B55A 4MSXA 4QRGA 2AU1A 3M99A 2CB5A 3I06A 2F1GA 1F2CA 5EGWA 2R9OA 1YK7A 1Q6KA 3MHSA 3IOQA 4W5CA 2R9FA 1W4TA 2DZZA 4NV8A 2AVWA 2Y6EA 4X6JA 1M6DA 2B1NA 2VHFA 1NB5A 5EF4A 2AUZA 2E00A 4PP1A 2NQIA 3OF9A 1KFXL 1YALA 4XR7A 2HH5A 2P7UA 3RVWA 1K3BB 3I3TA 1PPPA 1MIRA 1CS8A 8PCHA 1Y4HA 2YJCA 4YV8A 3PDFA 1MEMA 1GECE 3QT4A 1NLJA 4I05A 4CDDB 1PIPA 2NQDB 2R9CA 1CV8A 4OEMA 1STFE 4FJCA 4YYRA 3OISA 1W6FA 1U9QX 4BSQA 3P5VA 1NL6A 1SP4B 2G7YA 3IV2A 1S4VA 1BY8A 4GUZA 2AUXA 2H7JA 2R9NA 3F5VA 4FK5A 4K7CA 3H7DA 3CBKA 3QJ3A 1ME4A 1YK8A 1GMYA 1PPNA 4X6HA 3K8UA 3GCBA 3IMAA 4BS5A 4YYSA 2GFOA 2DC8A 2ARYA 1U9XA 2YJBA 5JH3A 4YYUA 1THEA 1X9YA 1AU4A 1F29A 1AYUA 4W5BA 1POPA 4CDCB 4QRVA 2C0YA 1TL9A 1HUCB 1Y08A 2R6NA 1QXPA 3OVXA 1F2AA 3KWBX 1MS6A 3O1GA 3V6EA 2DC9A 1AU2A 2HD5A 3O0UA 5A24A 3WXEA 3BOWA 4C5PA 2O6XA 3NHEA 1QMYA 1TU6A 4N4ZA 2OZ2A 4PADA 3AI8A 3USVA 4XUIA 4P6EA 1AYWA 1NPZA 4P6GA 3S3RA 3K24A 1MHWA 3P5WA 2AYOA 7PCKA 1VSNA 1QDQA 1GCBA 3KKUA 2G6DA 1NB3A 2NQGA 1E2TA 3E1ZB 3PNRA 2HHNA 1GLOA 4HWYA 3TNXA 2FTDA 4QBBA 4BS6A 1VJVA 4KLBA 3N3GA 4CZWA 1CB5A 1ZCMA 2VHSA 2FUDA 3KFQA 3ZUAA 4AXLA 3B79A 1CQDA 1ICFA 1F2BA 1XKGA 4BGFA 1PPOA 1PCIA 4YVAA 2HXZA 4DMYA 1AECA 4PP2E 3KW9A 3MTNA 5JA7A 3V6CA 1U9VA 1U9WA 3IUTA 4BPVA 2FRAA 4DMXA 1PBHA 4QH6A 4W4UA 2G8JA 2FO5A 1MEGA 5F02A 4PI3A 3LXSA 2AIMA 2AS8A 3S3QA 1CPJA 5J94A 2VFCA 2DC7A 4WA6A 3K9MA 2IPPB 4OELA 2R9MA 2DC6A 3WXGA 3CH2X 1MDWA 3IEJA 1GX3A 1AIMA 2P86A 2YJ2A 2PBHA 4G54A 3N3KA 3U8EA 1ZIVA 4YYWA 3LFYA 1EWMA 3H8BA 2DCDA 1EWPA 1KXRA 2DZYA 2FRQA 1JQPA 3HHIA 4MZSA 3ERVA 3HD3A 1DEUA 3CBJA 1AU3A 1A6RA 2B1MA 2PADA 2XU3A 2Y5BA 1O0EA 2FT2A 3BPFA 2OP3A 5CVMA 1PPDA 2DJGB 2AYNA 2FQ9A 5CHTA 9PAPA 1KFUL 2BSZA 1AU0A 2YJ8A 2G8EA 2XU1A 2ACTA 4N8WA 4Q8GA 1BP4A 3OVZA 4FIPA 2CIOA 2GHUA 2BDLA 1CVZA 3P5UA 3MORA 2PREA 3BC3A 3H8CA 2DJFB 3BWKA 4BQVA 5CVOB 1PADA 2DCBA 4YYVA 1IWDA 5CHVA 4ZUXU 1ME3A 2WBFX 3C9EA 2E02A 2IBIA 3HWNA 3MHHA 6PADA 2FYEA 3HHAA 2F7DA 4I07A 2YJ9A 3WXFA 4RY2A 5K16A 1U5IA 3KSEA 4YYQA 2XU4A 5PADA 1NQCA 2PNSA 3P5XA 4AXMA 2BDZA 1KHQA 3BPMA 4QRXA 2P0RA 1AYVA 1PE6A 1YT7A 2DCCA 4MZOA 1YVBA 3BCNA 2E01A 1BQIA 3KX1A 3LTWA 4N79A 2E03A 4NV7A 2VFBA 2JQFR 3OF8A 4X6IA 3QSDA 3CH3X 1EF7A 1EWLA 1ATKA 2ATOA 1W5RA 1CSBB 4Q8HA 3D6SA 4CDFB 3D9WA 1CJLA 1BGOA 2OULA 1EWOA 4I04A 3RVXA 1DF0A 3PBHA 2XU5A 2NQAA 1QOLA 3H6SA 1CTEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CVN B;  2JQG R;  5FPW A;  4CDE B;  3N4C A;  1PXV A;  3F75 A;  3H89 A;  1ITO A;  2DCA A;  3RVV A;  3IHP A;  1SNK A;  3DF0 A;  1FH0 A;  3KWZ A;  1TLO A;  1KHP A;  3PW3 A;  4MSX A;  4QRG A;  2AU1 A;  3M99 A;  2CB5 A;  3I06 A;  2F1G A;  1F2C A;  5EGW A;  2R9O A;  1YK7 A;  1Q6K A;  3MHS A;  3IOQ A;  4W5C A;  2R9F A;  2DZZ A;  2AVW A;  2Y6E A;  4X6J A;  1M6D A;  2B1N A;  2VHF A;  1NB5 A;  5EF4 A;  2AUZ A;  2E00 A;  4PP1 A;  2NQI A;  3OF9 A;  1KFX L;  1YAL A;  4XR7 A;  2HH5 A;  2P7U A;  3RVW A;  1K3B B;  3I3T A;  1PPP A;  1MIR A;  1CS8 A;  8PCH A;  1Y4H A;  2YJC A;  4YV8 A;  3PDF A;  1MEM A;  1GEC E;  3QT4 A;  1NLJ A;  4I05 A;  4CDD B;  1PIP A;  2NQD B;  2R9C A;  1CV8 A;  4OEM A;  1STF E;  4FJC A;  4YYR A;  3OIS A;  1U9Q X;  4BSQ A;  3P5V A;  1NL6 A;  1SP4 B;  2G7Y A;  3IV2 A;  1S4V A;  1BY8 A;  2AUX A;  2H7J A;  2R9N A;  3F5V A;  4FK5 A;  4K7C A;  3H7D A;  3CBK A;  3QJ3 A;  1ME4 A;  1YK8 A;  1GMY A;  1PPN A;  4X6H A;  3K8U A;  3GCB A;  3IMA A;  4BS5 A;  4YYS A;  2GFO A;  2DC8 A;  2ARY A;  1U9X A;  2YJB A;  5JH3 A;  4YYU A;  1THE A;  1X9Y A;  1AU4 A;  1F29 A;  1AYU A;  4W5B A;  1POP A;  4CDC B;  4QRV A;  2C0Y A;  1TL9 A;  1HUC B;  1Y08 A;  2R6N A;  1QXP A;  3OVX A;  1F2A A;  3KWB X;  1MS6 A;  3O1G A;  3V6E A;  2DC9 A;  1AU2 A;  2HD5 A;  3O0U A;  5A24 A;  3WXE A;  3BOW A;  2O6X A;  3NHE A;  1QMY A;  1TU6 A;  4N4Z A;  2OZ2 A;  4PAD A;  3AI8 A;  3USV A;  4XUI A;  4P6E A;  1AYW A;  1NPZ A;  4P6G A;  3S3R A;  3K24 A;  1MHW A;  3P5W A;  2AYO A;  7PCK A;  1VSN A;  1QDQ A;  1GCB A;  3KKU A;  2G6D A;  1NB3 A;  2NQG A;  3E1Z B;  3PNR A;  2HHN A;  1GLO A;  4HWY A;  3TNX A;  2FTD A;  4QBB A;  4BS6 A;  1VJV A;  4KLB A;  3N3G A;  4CZW A;  1CB5 A;  1ZCM A;  2VHS A;  2FUD A;  3KFQ A;  3ZUA A;  4AXL A;  3B79 A;  1CQD A;  1ICF A;  1F2B A;  1XKG A;  1PPO A;  1PCI A;  4YVA A;  2HXZ A;  4DMY A;  1AEC A;  4PP2 E;  3KW9 A;  3MTN A;  5JA7 A;  3V6C A;  1U9V A;  1U9W A;  3IUT A;  4BPV A;  2FRA A;  4DMX A;  1PBH A;  4QH6 A;  4W4U A;  2G8J A;  2FO5 A;  1MEG A;  5F02 A;  4PI3 A;  3LXS A;  2AIM A;  2AS8 A;  3S3Q A;  1CPJ A;  5J94 A;  2DC7 A;  4WA6 A;  3K9M A;  2IPP B;  4OEL A;  2R9M A;  2DC6 A;  3WXG A;  3CH2 X;  1MDW A;  3IEJ A;  1AIM A;  2P86 A;  2YJ2 A;  2PBH A;  4G54 A;  3N3K A;  3U8E A;  1ZIV A;  4YYW A;  3LFY A;  1EWM A;  3H8B A;  2DCD A;  1EWP A;  1KXR A;  2DZY A;  2FRQ A;  1JQP A;  3HHI A;  4MZS A;  3ERV A;  3HD3 A;  1DEU A;  3CBJ A;  1AU3 A;  1A6R A;  2B1M A;  2PAD A;  2XU3 A;  2Y5B A;  1O0E A;  2FT2 A;  3BPF A;  2OP3 A;  5CVM A;  1PPD A;  2DJG B;  2AYN A;  2FQ9 A;  5CHT A;  9PAP A;  1KFU L;  1AU0 A;  2YJ8 A;  2G8E A;  2XU1 A;  2ACT A;  4N8W A;  4Q8G A;  1BP4 A;  3OVZ A;  4FIP A;  2CIO A;  2GHU A;  2BDL A;  1CVZ A;  3P5U A;  3MOR A;  2PRE A;  3BC3 A;  3H8C A;  2DJF B;  3BWK A;  4BQV A;  5CVO B;  1PAD A;  2DCB A;  4YYV A;  1IWD A;  5CHV A;  4ZUX U;  1ME3 A;  2WBF X;  3C9E A;  2E02 A;  2IBI A;  3HWN A;  3MHH A;  6PAD A;  2FYE A;  3HHA A;  2F7D A;  4I07 A;  2YJ9 A;  3WXF A;  4RY2 A;  5K16 A;  1U5I A;  3KSE A;  4YYQ A;  2XU4 A;  5PAD A;  1NQC A;  2PNS A;  3P5X A;  4AXM A;  2BDZ A;  1KHQ A;  3BPM A;  4QRX A;  2P0R A;  1AYV A;  1PE6 A;  1YT7 A;  2DCC A;  4MZO A;  1YVB A;  3BCN A;  2E01 A;  1BQI A;  3KX1 A;  4N79 A;  2E03 A;  2JQF R;  3OF8 A;  4X6I A;  3QSD A;  3CH3 X;  1EF7 A;  1EWL A;  1ATK A;  2ATO A;  1CSB B;  4Q8H A;  3D6S A;  4CDF B;  1CJL A;  1BGO A;  2OUL A;  1EWO A;  4I04 A;  3RVX A;  1DF0 A;  3PBH A;  2XU5 A;  2NQA A;  1QOL A;  3H6S A;  1CTE A; 
#chains in the Genus database with same CATH topology
 5CVN B;  2JQG R;  5FPW A;  4CDE B;  3N4C A;  4RKX A;  4REZ A;  1PXV A;  3F75 A;  3H89 A;  1ITO A;  2DCA A;  3RVV A;  3IHP A;  1SNK A;  3DF0 A;  1FH0 A;  3KWZ A;  1TLO A;  1KHP A;  3PW3 A;  4MSX A;  4QRG A;  2AU1 A;  3M99 A;  2CB5 A;  3I06 A;  2F1G A;  4BOU A;  1F2C A;  3IFU A;  5EGW A;  2R9O A;  1YK7 A;  1Q6K A;  3MHS A;  2JRI A;  5JZE A;  3PSE A;  3IOQ A;  4W5C A;  3TRK A;  2R9F A;  2DZZ A;  2AVW A;  2Y6E A;  4X6J A;  4P16 A;  1M6D A;  2B1N A;  2UZJ A;  2VHF A;  1NB5 A;  5EF4 A;  2AUZ A;  2E00 A;  4PP1 A;  2NQI A;  3OF9 A;  1KFX L;  1YAL A;  3MP2 A;  4XR7 A;  2HH5 A;  2P7U A;  3RVW A;  1K3B B;  3I3T A;  1PPP A;  5E6J A;  2BU3 A;  2DOS A;  1MIR A;  1CS8 A;  8PCH A;  1Y4H A;  2YJC A;  4YV8 A;  3PDF A;  1MEM A;  1GEC E;  3QT4 A;  1NLJ A;  4I05 A;  4CDD B;  1DKI A;  1PIP A;  2NQD B;  2R9C A;  4D8E A;  1CV8 A;  4OEM A;  2AGA A;  1STF E;  4FJC A;  4YYR A;  3OIS A;  2HWK A;  1U9Q X;  4BSQ A;  3P5V A;  1NL6 A;  1SP4 B;  2G7Y A;  3IV2 A;  4WUR A;  1S4V A;  3PRM A;  1BY8 A;  2AUX A;  2H7J A;  2R9N A;  4PT5 A;  4RNA A;  3F5V A;  4FK5 A;  4K7C A;  3H7D A;  3CBK A;  3QJ3 A;  1ME4 A;  1YK8 A;  1GMY A;  1PPN A;  4X6H A;  3K8U A;  1YZB A;  2J7Q A;  5EZS A;  3GCB A;  3IMA A;  4BOS A;  4BS5 A;  4YYS A;  2GFO A;  2DC8 A;  2ARY A;  1U9X A;  2YJB A;  5JH3 A;  4YYU A;  1THE A;  4D8I A;  1X9Y A;  1AU4 A;  1F29 A;  1AYU A;  4W5B A;  1POP A;  4CDC B;  4QRV A;  2C0Y A;  1TL9 A;  4IP3 A;  1HUC B;  1Y08 A;  2R6N A;  1QXP A;  3OVX A;  1F2A A;  3KWB X;  4OVZ A;  1MS6 A;  3O1G A;  3V6E A;  2DC9 A;  4XZX A;  1AU2 A;  2HD5 A;  3O0U A;  5A24 A;  3WXE A;  4OVZ B;  3BOW A;  2O6X A;  3NHE A;  1QMY A;  1TU6 A;  4N4Z A;  3W31 A;  2OZ2 A;  3BBA A;  3ZNH A;  4PAD A;  3AI8 A;  3OQC A;  3USV A;  2JTC A;  4XUI A;  4P6E A;  1AYW A;  1NPZ A;  4P6G A;  3MTV A;  3S3R A;  3K24 A;  1MHW A;  3P5W A;  3MJ5 A;  3BY4 A;  2AYO A;  7PCK A;  1VSN A;  1QDQ A;  1GCB A;  3KKU A;  2G6D A;  4OW0 A;  1NB3 A;  2NQG A;  4RF1 A;  3E1Z B;  3PNR A;  2HHN A;  1GLO A;  4HWY A;  3TNX A;  2FTD A;  4QBB A;  4BS6 A;  1VJV A;  4KLB A;  4D8B A;  3N3G A;  2FE8 A;  4CZW A;  1CB5 A;  1ZCM A;  2VHS A;  2FUD A;  3KFQ A;  3ZUA A;  4AXL A;  1UKF A;  3B79 A;  1CQD A;  4GUA A;  1ICF A;  1F2B A;  1XKG A;  1PPO A;  1PCI A;  4YVA A;  2HXZ A;  4DMY A;  1AEC A;  3E9S A;  4PP2 E;  3KW9 A;  3MTN A;  5JA7 A;  3V6C A;  1U9V A;  1U9W A;  3IUT A;  4BPV A;  2FRA A;  4DMX A;  1PBH A;  4QH6 A;  4W4U A;  2G8J A;  2FO5 A;  1MEG A;  5F02 A;  4PI3 A;  4HXD B;  3LXS A;  2AIM A;  2AS8 A;  3S3Q A;  1CPJ A;  5J94 A;  3C0R A;  4ZTB A;  2DC7 A;  1PVJ A;  4WA6 A;  3K9M A;  2IPP B;  4OEL A;  2R9M A;  2DC6 A;  3WXG A;  3O65 A;  3CH2 X;  1MDW A;  3IEJ A;  1AIM A;  2BTW B;  2P86 A;  2YJ2 A;  2PBH A;  4G54 A;  3N3K A;  3U8E A;  1ZIV A;  4YYW A;  3LFY A;  5EZQ A;  1EWM A;  3H8B A;  2DCD A;  1EWP A;  3B21 A;  1KXR A;  2DZY A;  2FRQ A;  1JQP A;  3HHI A;  4MZS A;  3ERV A;  3HD3 A;  1DEU A;  3CBJ A;  1AU3 A;  1A6R A;  2B1M A;  2PAD A;  2XU3 A;  2Y5B A;  1O0E A;  3BB7 A;  2FT2 A;  4R3D A;  3BPF A;  4RF0 A;  2OP3 A;  5CVM A;  1PPD A;  2DJG B;  2AYN A;  2FQ9 A;  4BOP A;  5CHT A;  9PAP A;  1KFU L;  4BOQ A;  1AU0 A;  2YJ8 A;  2G8E A;  2XU1 A;  2ACT A;  4N8W A;  4Q8G A;  1BP4 A;  3OVZ A;  4FIP A;  2CIO A;  2GHU A;  2BDL A;  1CVZ A;  3P5U A;  3MOR A;  2PRE A;  3BC3 A;  5KO3 A;  3H8C A;  2DJF B;  3BWK A;  4M0W A;  4BQV A;  5CVO B;  1PAD A;  3W30 A;  2DCB A;  4YYV A;  1IWD A;  5CHV A;  4ZUX U;  2J7Q C;  1ME3 A;  2WBF X;  3C9E A;  2E02 A;  2IBI A;  3HWN A;  3MHH A;  6PAD A;  2FYE A;  3TMP A;  3HHA A;  2F7D A;  4IUM A;  4BOZ A;  4I07 A;  4A5U A;  4MM3 B;  2YJ9 A;  3WXF A;  4RY2 A;  4MI7 A;  3PHU A;  5K16 A;  3PHX A;  1U5I A;  3KSE A;  4YYQ A;  2XU4 A;  5PAD A;  1NQC A;  2PNS A;  3PHW A;  3P5X A;  4AXM A;  2BDZ A;  1KHQ A;  3PRP A;  3BPM A;  4QRX A;  2P0R A;  1AYV A;  1PE6 A;  1YT7 A;  2DCC A;  4MZO A;  2BTW A;  1YVB A;  3BCN A;  3PT2 A;  2E01 A;  1BQI A;  3KX1 A;  4N79 A;  2E03 A;  2JQF R;  3OF8 A;  4X6I A;  3QSD A;  3CH3 X;  1EF7 A;  1EWL A;  1ATK A;  3RNV A;  2ATO A;  1CSB B;  4Q8H A;  3D6S A;  4CDF B;  2Z84 A;  1CJL A;  1BGO A;  2OUL A;  1EWO A;  4I04 A;  3RVX A;  1DF0 A;  3PBH A;  2XU5 A;  2NQA A;  1QOL A;  3H6S A;  1CTE A; 
#chains in the Genus database with same CATH homology
 5CVN B;  2JQG R;  5FPW A;  4CDE B;  3N4C A;  1PXV A;  3F75 A;  3H89 A;  1ITO A;  2DCA A;  3RVV A;  3IHP A;  1SNK A;  3DF0 A;  1FH0 A;  3KWZ A;  1TLO A;  1KHP A;  3PW3 A;  4B55 A;  4MSX A;  4QRG A;  2AU1 A;  3M99 A;  2CB5 A;  3I06 A;  2F1G A;  1F2C A;  5EGW A;  2R9O A;  1YK7 A;  1Q6K A;  3MHS A;  3IOQ A;  4W5C A;  2R9F A;  1W4T A;  2DZZ A;  4NV8 A;  2AVW A;  2Y6E A;  4X6J A;  1M6D A;  2B1N A;  2VHF A;  1NB5 A;  5EF4 A;  2AUZ A;  2E00 A;  4PP1 A;  2NQI A;  3OF9 A;  1KFX L;  1YAL A;  4XR7 A;  2HH5 A;  2P7U A;  3RVW A;  1K3B B;  3I3T A;  1PPP A;  1MIR A;  1CS8 A;  8PCH A;  1Y4H A;  2YJC A;  4YV8 A;  3PDF A;  1MEM A;  1GEC E;  3QT4 A;  1NLJ A;  4I05 A;  4CDD B;  1PIP A;  2NQD B;  2R9C A;  1CV8 A;  4OEM A;  1STF E;  4FJC A;  4YYR A;  3OIS A;  1W6F A;  1U9Q X;  4BSQ A;  3P5V A;  1NL6 A;  1SP4 B;  2G7Y A;  3IV2 A;  1S4V A;  1BY8 A;  4GUZ A;  2AUX A;  2H7J A;  2R9N A;  3F5V A;  4FK5 A;  4K7C A;  3H7D A;  3CBK A;  3QJ3 A;  1ME4 A;  1YK8 A;  1GMY A;  1PPN A;  4X6H A;  3K8U A;  3GCB A;  3IMA A;  4BS5 A;  4YYS A;  2GFO A;  2DC8 A;  2ARY A;  1U9X A;  2YJB A;  5JH3 A;  4YYU A;  1THE A;  1X9Y A;  1AU4 A;  1F29 A;  1AYU A;  4W5B A;  1POP A;  4CDC B;  4QRV A;  2C0Y A;  1TL9 A;  1HUC B;  1Y08 A;  2R6N A;  1QXP A;  3OVX A;  1F2A A;  3KWB X;  1MS6 A;  3O1G A;  3V6E A;  2DC9 A;  1AU2 A;  2HD5 A;  3O0U A;  5A24 A;  3WXE A;  3BOW A;  4C5P A;  2O6X A;  3NHE A;  1QMY A;  1TU6 A;  4N4Z A;  2OZ2 A;  4PAD A;  3AI8 A;  3USV A;  4XUI A;  4P6E A;  1AYW A;  1NPZ A;  4P6G A;  3S3R A;  3K24 A;  1MHW A;  3P5W A;  2AYO A;  7PCK A;  1VSN A;  1QDQ A;  1GCB A;  3KKU A;  2G6D A;  1NB3 A;  2NQG A;  1E2T A;  3E1Z B;  3PNR A;  2HHN A;  1GLO A;  4HWY A;  3TNX A;  2FTD A;  4QBB A;  4BS6 A;  1VJV A;  4KLB A;  3N3G A;  4CZW A;  1CB5 A;  1ZCM A;  2VHS A;  2FUD A;  3KFQ A;  3ZUA A;  4AXL A;  3B79 A;  1CQD A;  1ICF A;  1F2B A;  1XKG A;  4BGF A;  1PPO A;  1PCI A;  4YVA A;  2HXZ A;  4DMY A;  1AEC A;  4PP2 E;  3KW9 A;  3MTN A;  5JA7 A;  3V6C A;  1U9V A;  1U9W A;  3IUT A;  4BPV A;  2FRA A;  4DMX A;  1PBH A;  4QH6 A;  4W4U A;  2G8J A;  2FO5 A;  1MEG A;  5F02 A;  4PI3 A;  3LXS A;  2AIM A;  2AS8 A;  3S3Q A;  1CPJ A;  5J94 A;  2VFC A;  2DC7 A;  4WA6 A;  3K9M A;  2IPP B;  4OEL A;  2R9M A;  2DC6 A;  3WXG A;  3CH2 X;  1MDW A;  3IEJ A;  1GX3 A;  1AIM A;  2P86 A;  2YJ2 A;  2PBH A;  4G54 A;  3N3K A;  3U8E A;  1ZIV A;  4YYW A;  3LFY A;  1EWM A;  3H8B A;  2DCD A;  1EWP A;  1KXR A;  2DZY A;  2FRQ A;  1JQP A;  3HHI A;  4MZS A;  3ERV A;  3HD3 A;  1DEU A;  3CBJ A;  1AU3 A;  1A6R A;  2B1M A;  2PAD A;  2XU3 A;  2Y5B A;  1O0E A;  2FT2 A;  3BPF A;  2OP3 A;  5CVM A;  1PPD A;  2DJG B;  2AYN A;  2FQ9 A;  5CHT A;  9PAP A;  1KFU L;  2BSZ A;  1AU0 A;  2YJ8 A;  2G8E A;  2XU1 A;  2ACT A;  4N8W A;  4Q8G A;  1BP4 A;  3OVZ A;  4FIP A;  2CIO A;  2GHU A;  2BDL A;  1CVZ A;  3P5U A;  3MOR A;  2PRE A;  3BC3 A;  3H8C A;  2DJF B;  3BWK A;  4BQV A;  5CVO B;  1PAD A;  2DCB A;  4YYV A;  1IWD A;  5CHV A;  4ZUX U;  1ME3 A;  2WBF X;  3C9E A;  2E02 A;  2IBI A;  3HWN A;  3MHH A;  6PAD A;  2FYE A;  3HHA A;  2F7D A;  4I07 A;  2YJ9 A;  3WXF A;  4RY2 A;  5K16 A;  1U5I A;  3KSE A;  4YYQ A;  2XU4 A;  5PAD A;  1NQC A;  2PNS A;  3P5X A;  4AXM A;  2BDZ A;  1KHQ A;  3BPM A;  4QRX A;  2P0R A;  1AYV A;  1PE6 A;  1YT7 A;  2DCC A;  4MZO A;  1YVB A;  3BCN A;  2E01 A;  1BQI A;  3KX1 A;  3LTW A;  4N79 A;  2E03 A;  4NV7 A;  2VFB A;  2JQF R;  3OF8 A;  4X6I A;  3QSD A;  3CH3 X;  1EF7 A;  1EWL A;  1ATK A;  2ATO A;  1W5R A;  1CSB B;  4Q8H A;  3D6S A;  4CDF B;  3D9W A;  1CJL A;  1BGO A;  2OUL A;  1EWO A;  4I04 A;  3RVX A;  1DF0 A;  3PBH A;  2XU5 A;  2NQA A;  1QOL A;  3H6S A;  1CTE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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