2P86A

The high resolution crystal structure of rhodesain, the major cathepsin l protease from t. brucei rhodesiense, bound to inhibitor k11002
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
215
structure length
214
Chain Sequence
APAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVSCDTIDFGCGGGLMDNAFNWIVNSNGGNVFTASYPYVSGNGEQPQCQMNGHEIGAAITDHVDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDASNPPYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title THE high resolution structure of rhodesain, the major cathepsin L protease from trypanosoma brucei rhodesiense, illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases
rcsb
molecule tags Hydrolase
source organism Trypanosoma brucei rhodesiense
molecule keywords Cysteine protease
total genus 64
structure length 214
sequence length 215
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2007-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 2p86A00
4AXLA 3P5VA 1YVBA 3B79A 1EWOA 1DF0A 5CVNB 2P7UA 4P6EA 1JQPA 4Q8HA 3S3QA 1U9VA 1AECA 4CZWA 1CVZA 1ZIVA 1AU3A 3N4CA 2IBIA 3M99A 2AUXA 2R9FA 2YJ2A 2JQGR 3H6SA 1KHPA 3K24A 1VJVA 2XU5A 1F2BA 1U5IA 3K9MA 4I05A 2R9MA 3BPFA 4I04A 3MORA 1M6DA 3KX1A 1U9XA 3OISA 1YT7A 2DC8A 2OP3A 3QJ3A 3D6SA 4BQVA 2NQGA 3PNRA 3U8EA 4YYRA 3IUTA 2G7YA 2F1GA 8PCHA 2AU1A 5CVMA 3OVZA 4N8WA 4CDDB 4YYVA 2DCCA 2Y5BA 1TL9A 3NHEA 4QBBA 1ME3A 1PE6A 1YK7A 4PI3A 1YK8A 1FH0A 1U9QX 4YYQA 5PADA 2PBHA 2XU4A 1PPOA 3H8CA 2PREA 2FYEA 4FIPA 1KXRA 1PCIA 1CSBB 1SNKA 3AI8A 2E01A 1ITOA 1PADA 3MHHA 1EWLA 3HHIA 4FJCA 4P6GA 3DF0A 1PIPA 2CIOA 3ZUAA 3K8UA 3KWBX 1NLJA 3I3TA 2P0RA 1KFUL 1EF7A 4YV8A 3RVXA 2NQDB 1GMYA 4CDCB 4DMYA 4G54A 1PBHA 1AIMA 2R9CA 1STFE 1KHQA 1BGOA 3F5VA 3CBJA 1TU6A 3CBKA 4W5BA 4AXMA 1QDQA 9PAPA 4PADA 4XUIA 3N3KA 5J94A 3PDFA 1CPJA 4BSQA 2NQAA 1K3BB 1IWDA 4BS5A 2PADA 7PCKA 3OVXA 1AYUA 3USVA 2ARYA 2CB5A 3MTNA 1A6RA 3TNXA 2OULA 1QXPA 1KFXL 3BOWA 2HH5A 1MIRA 3BWKA 3BPMA 1AYVA 4OEMA 3P5XA 2P86A 2YJCA 3KFQA 4W4UA 1YALA 1CB5A 4X6HA 2DC7A 1ME4A 1F2AA 4PP2E 1THEA 2AS8A 2AYNA 3LFYA 2B1MA 2AVWA 2G8JA 3IV2A 1Y08A 2PNSA 4DMXA 1S4VA 3KKUA 1SP4B 1Y4HA 3P5WA 1NB3A 2R9OA 1O0EA 4X6JA 4YYUA 3N3GA 2ACTA 3V6EA 4I07A 2BDZA 4N79A 2FUDA 2YJ9A 2O6XA 1ZCMA 1HUCB 4N4ZA 3CH3X 2YJ8A 1AYWA 4QRXA 5CVOB 1AU4A 2FO5A 3PBHA 1CV8A 3IEJA 3IHPA 1AU0A 2FRAA 3KWZA 3WXFA 2AYOA 1POPA 2FT2A 2R6NA 4OELA 1EWMA 1PPDA 5K16A 4QRGA 1NB5A 2VHFA 4QH6A 2DCAA 2AIMA 3OF8A 6PADA 1F2CA 3H89A 1DEUA 2XU1A 2DZZA 2H7JA 1MS6A 1PXVA 1CTEA 3WXEA 3OF9A 2DCBA 2WBFX 3I06A 1BQIA 1BY8A 3O0UA 4FK5A 1GECE 1CJLA 1BP4A 4KLBA 5EGWA 3E1ZB 1MEGA 4PP1A 2NQIA 2DCDA 3C9EA 3LXSA 4X6IA 1AU2A 1NL6A 2DJGB 1GLOA 2G6DA 4YYSA 3F75A 2R9NA 3KSEA 3HWNA 2XU3A 4WA6A 2AUZA 3O1GA 1ICFA 3RVVA 5A24A 2JQFR 4CDFB 5F02A 2VHSA 4W5CA 4MZSA 1PPPA 1NPZA 5EF4A 4HWYA 5FPWA 3BCNA 4CDEB 3BC3A 5CHVA 1CS8A 3QT4A 4QRVA 2HHNA 3RVWA 1CQDA 3GCBA 2GFOA 2HXZA 1U9WA 1MHWA 1Q6KA 2F7DA 1VSNA 1NQCA 2DC9A 3CH2X 2OZ2A 4MZOA 3ERVA 4Q8GA 4BS6A 2FQ9A 3S3RA 1TLOA 1MEMA 1GCBA 2FRQA 5JH3A 3IOQA 3MHSA 4MSXA 2DZYA 2B1NA 3WXGA 3HHAA 2DC6A 1QMYA 1X9YA 3PW3A 1MDWA 3P5UA 1EWPA 4XR7A 2GHUA 2YJBA 2BDLA 2E03A 2Y6EA 2ATOA 3QSDA 3IMAA 2HD5A 1XKGA 4BPVA 4K7CA 5CHTA 4RY2A 2E02A 4YYWA 2IPPB 3H8BA 2E00A 2G8EA 3HD3A 5JA7A 3V6CA 4ZUXU 4YVAA 1PPNA 1ATKA 3KW9A 2C0YA 1F29A 1QOLA 2FTDA 2DJFB 3H7DA
chains in the Genus database with same CATH superfamily
3BBAA 4AXLA 3P5VA 1YVBA 2HWKA 3B79A 4OVZB 3PRPA 1EWOA 1DF0A 5CVNB 2P7UA 4P6EA 1JQPA 4Q8HA 3S3QA 1U9VA 1AECA 4CZWA 1CVZA 1ZIVA 3PRMA 1AU3A 3N4CA 2IBIA 3M99A 2AUXA 2R9FA 2YJ2A 4OVZA 2JQGR 3H6SA 1KHPA 3K24A 1VJVA 5E6JA 2XU5A 1F2BA 1U5IA 4RF0A 3K9MA 4I05A 2R9MA 3BPFA 4I04A 3MORA 1M6DA 3KX1A 1U9XA 3OISA 1YT7A 2DC8A 2OP3A 3QJ3A 3D6SA 2JRIA 4BQVA 2NQGA 4RNAA 3PNRA 3U8EA 4YYRA 3IUTA 2G7YA 2F1GA 8PCHA 2AU1A 5CVMA 3OVZA 4N8WA 4CDDB 2J7QC 4YYVA 3TMPA 2DCCA 2Y5BA 4IUMA 4GUAA 1TL9A 3NHEA 4QBBA 3IFUA 1ME3A 1PE6A 1YK7A 4PI3A 1YK8A 1FH0A 4RKXA 1U9QX 4YYQA 5PADA 2PBHA 2XU4A 1PPOA 3H8CA 2PREA 2FYEA 4FIPA 1KXRA 1PCIA 1CSBB 1SNKA 3AI8A 2E01A 1ITOA 1PADA 3MHHA 1EWLA 3HHIA 2BU3A 4FJCA 4P6GA 3DF0A 1PIPA 2CIOA 3ZUAA 3K8UA 3KWBX 2AGAA 1NLJA 3I3TA 2P0RA 1KFUL 1EF7A 4YV8A 4ZTBA 3ZNHA 3RVXA 2NQDB 1GMYA 4MI7A 4CDCB 4DMYA 4G54A 3PHXA 1PBHA 1AIMA 2R9CA 1STFE 3W30A 1KHQA 1BGOA 3F5VA 3CBJA 1TU6A 3CBKA 4W5BA 4AXMA 1QDQA 9PAPA 3O65A 4PADA 4XUIA 3W31A 3N3KA 5J94A 3PDFA 1CPJA 4BSQA 2NQAA 4BOPA 1K3BB 1IWDA 4BS5A 2PADA 7PCKA 3OVXA 1AYUA 3USVA 2ARYA 2CB5A 3MTNA 1A6RA 3RNVA 3TNXA 2OULA 4MM3B 1QXPA 1KFXL 3BOWA 2HH5A 1MIRA 3BWKA 3BPMA 1AYVA 4PT5A 4OEMA 3P5XA 2YJCA 2P86A 3KFQA 3TRKA 2UZJA 4W4UA 1YALA 1CB5A 4X6HA 2DC7A 1ME4A 3PT2A 3PHUA 2Z84A 1F2AA 3PSEA 3MP2A 4PP2E 1THEA 2AS8A 4A5UA 2AYNA 3LFYA 2B1MA 2AVWA 2G8JA 3IV2A 1Y08A 2PNSA 4DMXA 1S4VA 3KKUA 1SP4B 2JTCA 1Y4HA 3C0RA 3P5WA 1NB3A 2R9OA 1O0EA 4M0WA 4X6JA 4YYUA 3N3GA 2ACTA 3V6EA 2FE8A 4I07A 2BDZA 4N79A 2FUDA 2YJ9A 2O6XA 1ZCMA 3OQCA 1HUCB 4N4ZA 3CH3X 4BOUA 2YJ8A 3MTVA 1AYWA 4QRXA 5CVOB 1AU4A 3MJ5A 2FO5A 3PBHA 1CV8A 3IEJA 3IHPA 1AU0A 2FRAA 3KWZA 3WXFA 2AYOA 1POPA 2FT2A 4D8BA 2R6NA 4OELA 1EWMA 1PPDA 5K16A 4QRGA 4IP3A 1NB5A 2VHFA 1PVJA 4QH6A 2DCAA 2AIMA 3OF8A 6PADA 1F2CA 3H89A 1DEUA 2XU1A 2DZZA 2H7JA 1MS6A 1PXVA 1CTEA 3WXEA 3OF9A 2DCBA 2WBFX 3I06A 4OW0A 1BQIA 1BY8A 3O0UA 4FK5A 1GECE 1CJLA 1BP4A 4KLBA 5EGWA 3E1ZB 1MEGA 4PP1A 2NQIA 2DCDA 3C9EA 3LXSA 4X6IA 5JZEA 2J7QA 1AU2A 1NL6A 2DJGB 1GLOA 2G6DA 4YYSA 3F75A 2R9NA 3KSEA 3B21A 5EZQA 3HWNA 2XU3A 4WA6A 4REZA 2AUZA 3O1GA 1ICFA 3RVVA 5A24A 2JQFR 4CDFB 5F02A 4XZXA 2VHSA 4W5CA 4MZSA 1PPPA 1UKFA 1NPZA 5EF4A 4BOQA 4HWYA 5FPWA 3BCNA 4CDEB 3BC3A 5CHVA 4BOZA 1CS8A 3QT4A 4QRVA 4HXDB 2HHNA 3RVWA 1CQDA 3GCBA 4D8EA 2GFOA 2HXZA 1U9WA 1MHWA 1Q6KA 2F7DA 1VSNA 1NQCA 2DC9A 3CH2X 2OZ2A 4MZOA 3ERVA 4Q8GA 4BS6A 4D8IA 2FQ9A 3S3RA 1TLOA 1MEMA 1GCBA 2FRQA 5JH3A 3IOQA 2BTWB 3MHSA 4MSXA 2DZYA 5EZSA 2B1NA 3WXGA 3HHAA 2DC6A 1QMYA 3PHWA 1X9YA 3PW3A 1MDWA 3P5UA 5KO3A 1EWPA 3BY4A 3E9SA 4XR7A 2GHUA 2YJBA 2BDLA 4P16A 2E03A 2Y6EA 2ATOA 3QSDA 2BTWA 3IMAA 2HD5A 1XKGA 4BOSA 4BPVA 4K7CA 5CHTA 4RY2A 2E02A 4YYWA 2IPPB 3H8BA 2E00A 1YZBA 2DOSA 4WURA 2G8EA 3HD3A 1DKIA 5JA7A 3V6CA 4ZUXU 4YVAA 1PPNA 4R3DA 1ATKA 3KW9A 4RF1A 2C0YA 1F29A 1QOLA 3BB7A 2FTDA 2DJFB 3H7DA
chains in the Genus database with same CATH topology
4AXLA 3P5VA 1YVBA 3B79A 1EWOA 1DF0A 5CVNB 2P7UA 4P6EA 1JQPA 4Q8HA 3S3QA 1U9VA 1AECA 2VFBA 4CZWA 1CVZA 1ZIVA 1AU3A 3N4CA 2IBIA 3M99A 2AUXA 2R9FA 2YJ2A 2JQGR 3H6SA 1KHPA 3K24A 1VJVA 2XU5A 1F2BA 1U5IA 3K9MA 4I05A 2R9MA 3BPFA 4I04A 3MORA 1M6DA 3KX1A 1U9XA 3OISA 1YT7A 2DC8A 2OP3A 3QJ3A 3D6SA 4BQVA 2NQGA 3D9WA 3PNRA 3U8EA 4YYRA 3IUTA 2G7YA 2F1GA 8PCHA 2AU1A 5CVMA 3OVZA 1W4TA 4N8WA 4CDDB 4YYVA 2DCCA 2Y5BA 1TL9A 3NHEA 4QBBA 1ME3A 1PE6A 1YK7A 4PI3A 1YK8A 1FH0A 1U9QX 4YYQA 5PADA 2PBHA 2XU4A 1PPOA 3H8CA 2PREA 2FYEA 4FIPA 1KXRA 1PCIA 1CSBB 1SNKA 3AI8A 2E01A 1ITOA 1PADA 3MHHA 1EWLA 3HHIA 4FJCA 4P6GA 3DF0A 1PIPA 2CIOA 3ZUAA 3K8UA 3KWBX 1NLJA 3I3TA 2P0RA 1KFUL 1EF7A 4YV8A 3RVXA 2NQDB 1GMYA 4CDCB 4DMYA 4G54A 1PBHA 1AIMA 2R9CA 1STFE 1KHQA 1BGOA 3F5VA 3CBJA 1TU6A 3CBKA 4W5BA 4AXMA 1QDQA 9PAPA 4PADA 4XUIA 3N3KA 5J94A 3PDFA 1CPJA 4BSQA 2NQAA 1K3BB 1IWDA 4BS5A 2PADA 7PCKA 3OVXA 1AYUA 3USVA 2ARYA 2CB5A 3MTNA 1A6RA 3TNXA 2OULA 1QXPA 2BSZA 1KFXL 3BOWA 2HH5A 1MIRA 3BWKA 3BPMA 1AYVA 4OEMA 3P5XA 2P86A 2YJCA 3KFQA 4W4UA 1YALA 1CB5A 4X6HA 2DC7A 1ME4A 1F2AA 4NV8A 4PP2E 1THEA 2AS8A 1GX3A 2AYNA 3LFYA 2B1MA 2AVWA 2G8JA 3IV2A 1Y08A 2PNSA 4DMXA 1S4VA 3KKUA 1SP4B 1Y4HA 3P5WA 1NB3A 2R9OA 1O0EA 4X6JA 4YYUA 3N3GA 2ACTA 3V6EA 4I07A 2BDZA 4N79A 2FUDA 2YJ9A 2O6XA 1ZCMA 1HUCB 4N4ZA 3CH3X 2YJ8A 1AYWA 4QRXA 5CVOB 1AU4A 4GUZA 2FO5A 3PBHA 1CV8A 3IEJA 3IHPA 1AU0A 2FRAA 3KWZA 3WXFA 2AYOA 1POPA 2FT2A 2R6NA 4OELA 1EWMA 1PPDA 5K16A 4QRGA 1NB5A 2VHFA 4QH6A 2DCAA 2AIMA 3OF8A 1E2TA 6PADA 1F2CA 3H89A 1DEUA 2XU1A 2DZZA 2H7JA 1MS6A 1PXVA 1CTEA 3WXEA 3OF9A 2DCBA 2WBFX 3I06A 4NV7A 1BQIA 1BY8A 3O0UA 4B55A 4FK5A 1GECE 1CJLA 1BP4A 4KLBA 5EGWA 3E1ZB 1MEGA 4PP1A 2NQIA 2DCDA 3C9EA 1W6FA 3LXSA 4X6IA 1AU2A 1NL6A 2DJGB 1GLOA 2G6DA 4YYSA 3F75A 2R9NA 3KSEA 3HWNA 2XU3A 4WA6A 2VFCA 2AUZA 3O1GA 1ICFA 3RVVA 5A24A 2JQFR 4CDFB 5F02A 2VHSA 4W5CA 4MZSA 1PPPA 1NPZA 5EF4A 4HWYA 5FPWA 3BCNA 4CDEB 3BC3A 5CHVA 1CS8A 3QT4A 4QRVA 2HHNA 3RVWA 1CQDA 3GCBA 1W5RA 2GFOA 2HXZA 1U9WA 1MHWA 1Q6KA 2F7DA 1VSNA 1NQCA 2DC9A 3CH2X 2OZ2A 4MZOA 3ERVA 4Q8GA 3LTWA 4BS6A 2FQ9A 3S3RA 1TLOA 1MEMA 1GCBA 2FRQA 5JH3A 3IOQA 3MHSA 4MSXA 2DZYA 2B1NA 3WXGA 3HHAA 2DC6A 1QMYA 1X9YA 3PW3A 1MDWA 3P5UA 1EWPA 4XR7A 2GHUA 2YJBA 2BDLA 2E03A 2Y6EA 2ATOA 3QSDA 3IMAA 2HD5A 1XKGA 4BPVA 4K7CA 5CHTA 4RY2A 2E02A 4YYWA 2IPPB 3H8BA 2E00A 4C5PA 2G8EA 3HD3A 5JA7A 3V6CA 4ZUXU 4YVAA 1PPNA 1ATKA 3KW9A 2C0YA 1F29A 1QOLA 2FTDA 4BGFA 2DJFB 3H7DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AXL A;  3P5V A;  1YVB A;  3B79 A;  1EWO A;  1DF0 A;  5CVN B;  2P7U A;  4P6E A;  1JQP A;  4Q8H A;  3S3Q A;  1U9V A;  1AEC A;  4CZW A;  1CVZ A;  1ZIV A;  1AU3 A;  3N4C A;  2IBI A;  3M99 A;  2AUX A;  2R9F A;  2YJ2 A;  2JQG R;  3H6S A;  1KHP A;  3K24 A;  1VJV A;  2XU5 A;  1F2B A;  1U5I A;  3K9M A;  4I05 A;  2R9M A;  3BPF A;  4I04 A;  3MOR A;  1M6D A;  3KX1 A;  1U9X A;  3OIS A;  1YT7 A;  2DC8 A;  2OP3 A;  3QJ3 A;  3D6S A;  4BQV A;  2NQG A;  3PNR A;  3U8E A;  4YYR A;  3IUT A;  2G7Y A;  2F1G A;  8PCH A;  2AU1 A;  5CVM A;  3OVZ A;  4N8W A;  4CDD B;  4YYV A;  2DCC A;  2Y5B A;  1TL9 A;  3NHE A;  4QBB A;  1ME3 A;  1PE6 A;  1YK7 A;  4PI3 A;  1YK8 A;  1FH0 A;  1U9Q X;  4YYQ A;  5PAD A;  2PBH A;  2XU4 A;  1PPO A;  3H8C A;  2PRE A;  2FYE A;  4FIP A;  1KXR A;  1PCI A;  1CSB B;  1SNK A;  3AI8 A;  2E01 A;  1ITO A;  1PAD A;  3MHH A;  1EWL A;  3HHI A;  4FJC A;  4P6G A;  3DF0 A;  1PIP A;  2CIO A;  3ZUA A;  3K8U A;  3KWB X;  1NLJ A;  3I3T A;  2P0R A;  1KFU L;  1EF7 A;  4YV8 A;  3RVX A;  2NQD B;  1GMY A;  4CDC B;  4DMY A;  4G54 A;  1PBH A;  1AIM A;  2R9C A;  1STF E;  1KHQ A;  1BGO A;  3F5V A;  3CBJ A;  1TU6 A;  3CBK A;  4W5B A;  4AXM A;  1QDQ A;  9PAP A;  4PAD A;  4XUI A;  3N3K A;  5J94 A;  3PDF A;  1CPJ A;  4BSQ A;  2NQA A;  1K3B B;  1IWD A;  4BS5 A;  2PAD A;  7PCK A;  3OVX A;  1AYU A;  3USV A;  2ARY A;  2CB5 A;  3MTN A;  1A6R A;  3TNX A;  2OUL A;  1QXP A;  1KFX L;  3BOW A;  2HH5 A;  1MIR A;  3BWK A;  3BPM A;  1AYV A;  4OEM A;  3P5X A;  2P86 A;  2YJC A;  3KFQ A;  4W4U A;  1YAL A;  1CB5 A;  4X6H A;  2DC7 A;  1ME4 A;  1F2A A;  4PP2 E;  1THE A;  2AS8 A;  2AYN A;  3LFY A;  2B1M A;  2AVW A;  2G8J A;  3IV2 A;  1Y08 A;  2PNS A;  4DMX A;  1S4V A;  3KKU A;  1SP4 B;  1Y4H A;  3P5W A;  1NB3 A;  2R9O A;  1O0E A;  4X6J A;  4YYU A;  3N3G A;  2ACT A;  3V6E A;  4I07 A;  2BDZ A;  4N79 A;  2FUD A;  2YJ9 A;  2O6X A;  1ZCM A;  1HUC B;  4N4Z A;  3CH3 X;  2YJ8 A;  1AYW A;  4QRX A;  5CVO B;  1AU4 A;  2FO5 A;  3PBH A;  1CV8 A;  3IEJ A;  3IHP A;  1AU0 A;  2FRA A;  3KWZ A;  3WXF A;  2AYO A;  1POP A;  2FT2 A;  2R6N A;  4OEL A;  1EWM A;  1PPD A;  5K16 A;  4QRG A;  1NB5 A;  2VHF A;  4QH6 A;  2DCA A;  2AIM A;  3OF8 A;  6PAD A;  1F2C A;  3H89 A;  1DEU A;  2XU1 A;  2DZZ A;  2H7J A;  1MS6 A;  1PXV A;  1CTE A;  3WXE A;  3OF9 A;  2DCB A;  2WBF X;  3I06 A;  1BQI A;  1BY8 A;  3O0U A;  4FK5 A;  1GEC E;  1CJL A;  1BP4 A;  4KLB A;  5EGW A;  3E1Z B;  1MEG A;  4PP1 A;  2NQI A;  2DCD A;  3C9E A;  3LXS A;  4X6I A;  1AU2 A;  1NL6 A;  2DJG B;  1GLO A;  2G6D A;  4YYS A;  3F75 A;  2R9N A;  3KSE A;  3HWN A;  2XU3 A;  4WA6 A;  2AUZ A;  3O1G A;  1ICF A;  3RVV A;  5A24 A;  2JQF R;  4CDF B;  5F02 A;  2VHS A;  4W5C A;  4MZS A;  1PPP A;  1NPZ A;  5EF4 A;  4HWY A;  5FPW A;  3BCN A;  4CDE B;  3BC3 A;  5CHV A;  1CS8 A;  3QT4 A;  4QRV A;  2HHN A;  3RVW A;  1CQD A;  3GCB A;  2GFO A;  2HXZ A;  1U9W A;  1MHW A;  1Q6K A;  2F7D A;  1VSN A;  1NQC A;  2DC9 A;  3CH2 X;  2OZ2 A;  4MZO A;  3ERV A;  4Q8G A;  4BS6 A;  2FQ9 A;  3S3R A;  1TLO A;  1MEM A;  1GCB A;  2FRQ A;  5JH3 A;  3IOQ A;  3MHS A;  4MSX A;  2DZY A;  2B1N A;  3WXG A;  3HHA A;  2DC6 A;  1QMY A;  1X9Y A;  3PW3 A;  1MDW A;  3P5U A;  1EWP A;  4XR7 A;  2GHU A;  2YJB A;  2BDL A;  2E03 A;  2Y6E A;  2ATO A;  3QSD A;  3IMA A;  2HD5 A;  1XKG A;  4BPV A;  4K7C A;  5CHT A;  4RY2 A;  2E02 A;  4YYW A;  2IPP B;  3H8B A;  2E00 A;  2G8E A;  3HD3 A;  5JA7 A;  3V6C A;  4ZUX U;  4YVA A;  1PPN A;  1ATK A;  3KW9 A;  2C0Y A;  1F29 A;  1QOL A;  2FTD A;  2DJF B;  3H7D A; 
#chains in the Genus database with same CATH topology
 3BBA A;  4AXL A;  3P5V A;  1YVB A;  2HWK A;  3B79 A;  4OVZ B;  3PRP A;  1EWO A;  1DF0 A;  5CVN B;  2P7U A;  4P6E A;  1JQP A;  4Q8H A;  3S3Q A;  1U9V A;  1AEC A;  4CZW A;  1CVZ A;  1ZIV A;  3PRM A;  1AU3 A;  3N4C A;  2IBI A;  3M99 A;  2AUX A;  2R9F A;  2YJ2 A;  4OVZ A;  2JQG R;  3H6S A;  1KHP A;  3K24 A;  1VJV A;  5E6J A;  2XU5 A;  1F2B A;  1U5I A;  4RF0 A;  3K9M A;  4I05 A;  2R9M A;  3BPF A;  4I04 A;  3MOR A;  1M6D A;  3KX1 A;  1U9X A;  3OIS A;  1YT7 A;  2DC8 A;  2OP3 A;  3QJ3 A;  3D6S A;  2JRI A;  4BQV A;  2NQG A;  4RNA A;  3PNR A;  3U8E A;  4YYR A;  3IUT A;  2G7Y A;  2F1G A;  8PCH A;  2AU1 A;  5CVM A;  3OVZ A;  4N8W A;  4CDD B;  2J7Q C;  4YYV A;  3TMP A;  2DCC A;  2Y5B A;  4IUM A;  4GUA A;  1TL9 A;  3NHE A;  4QBB A;  3IFU A;  1ME3 A;  1PE6 A;  1YK7 A;  4PI3 A;  1YK8 A;  1FH0 A;  4RKX A;  1U9Q X;  4YYQ A;  5PAD A;  2PBH A;  2XU4 A;  1PPO A;  3H8C A;  2PRE A;  2FYE A;  4FIP A;  1KXR A;  1PCI A;  1CSB B;  1SNK A;  3AI8 A;  2E01 A;  1ITO A;  1PAD A;  3MHH A;  1EWL A;  3HHI A;  2BU3 A;  4FJC A;  4P6G A;  3DF0 A;  1PIP A;  2CIO A;  3ZUA A;  3K8U A;  3KWB X;  2AGA A;  1NLJ A;  3I3T A;  2P0R A;  1KFU L;  1EF7 A;  4YV8 A;  4ZTB A;  3ZNH A;  3RVX A;  2NQD B;  1GMY A;  4MI7 A;  4CDC B;  4DMY A;  4G54 A;  3PHX A;  1PBH A;  1AIM A;  2R9C A;  1STF E;  3W30 A;  1KHQ A;  1BGO A;  3F5V A;  3CBJ A;  1TU6 A;  3CBK A;  4W5B A;  4AXM A;  1QDQ A;  9PAP A;  3O65 A;  4PAD A;  4XUI A;  3W31 A;  3N3K A;  5J94 A;  3PDF A;  1CPJ A;  4BSQ A;  2NQA A;  4BOP A;  1K3B B;  1IWD A;  4BS5 A;  2PAD A;  7PCK A;  3OVX A;  1AYU A;  3USV A;  2ARY A;  2CB5 A;  3MTN A;  1A6R A;  3RNV A;  3TNX A;  2OUL A;  4MM3 B;  1QXP A;  1KFX L;  3BOW A;  2HH5 A;  1MIR A;  3BWK A;  3BPM A;  1AYV A;  4PT5 A;  4OEM A;  3P5X A;  2YJC A;  2P86 A;  3KFQ A;  3TRK A;  2UZJ A;  4W4U A;  1YAL A;  1CB5 A;  4X6H A;  2DC7 A;  1ME4 A;  3PT2 A;  3PHU A;  2Z84 A;  1F2A A;  3PSE A;  3MP2 A;  4PP2 E;  1THE A;  2AS8 A;  4A5U A;  2AYN A;  3LFY A;  2B1M A;  2AVW A;  2G8J A;  3IV2 A;  1Y08 A;  2PNS A;  4DMX A;  1S4V A;  3KKU A;  1SP4 B;  2JTC A;  1Y4H A;  3C0R A;  3P5W A;  1NB3 A;  2R9O A;  1O0E A;  4M0W A;  4X6J A;  4YYU A;  3N3G A;  2ACT A;  3V6E A;  2FE8 A;  4I07 A;  2BDZ A;  4N79 A;  2FUD A;  2YJ9 A;  2O6X A;  1ZCM A;  3OQC A;  1HUC B;  4N4Z A;  3CH3 X;  4BOU A;  2YJ8 A;  3MTV A;  1AYW A;  4QRX A;  5CVO B;  1AU4 A;  3MJ5 A;  2FO5 A;  3PBH A;  1CV8 A;  3IEJ A;  3IHP A;  1AU0 A;  2FRA A;  3KWZ A;  3WXF A;  2AYO A;  1POP A;  2FT2 A;  4D8B A;  2R6N A;  4OEL A;  1EWM A;  1PPD A;  5K16 A;  4QRG A;  4IP3 A;  1NB5 A;  2VHF A;  1PVJ A;  4QH6 A;  2DCA A;  2AIM A;  3OF8 A;  6PAD A;  1F2C A;  3H89 A;  1DEU A;  2XU1 A;  2DZZ A;  2H7J A;  1MS6 A;  1PXV A;  1CTE A;  3WXE A;  3OF9 A;  2DCB A;  2WBF X;  3I06 A;  4OW0 A;  1BQI A;  1BY8 A;  3O0U A;  4FK5 A;  1GEC E;  1CJL A;  1BP4 A;  4KLB A;  5EGW A;  3E1Z B;  1MEG A;  4PP1 A;  2NQI A;  2DCD A;  3C9E A;  3LXS A;  4X6I A;  5JZE A;  2J7Q A;  1AU2 A;  1NL6 A;  2DJG B;  1GLO A;  2G6D A;  4YYS A;  3F75 A;  2R9N A;  3KSE A;  3B21 A;  5EZQ A;  3HWN A;  2XU3 A;  4WA6 A;  4REZ A;  2AUZ A;  3O1G A;  1ICF A;  3RVV A;  5A24 A;  2JQF R;  4CDF B;  5F02 A;  4XZX A;  2VHS A;  4W5C A;  4MZS A;  1PPP A;  1UKF A;  1NPZ A;  5EF4 A;  4BOQ A;  4HWY A;  5FPW A;  3BCN A;  4CDE B;  3BC3 A;  5CHV A;  4BOZ A;  1CS8 A;  3QT4 A;  4QRV A;  4HXD B;  2HHN A;  3RVW A;  1CQD A;  3GCB A;  4D8E A;  2GFO A;  2HXZ A;  1U9W A;  1MHW A;  1Q6K A;  2F7D A;  1VSN A;  1NQC A;  2DC9 A;  3CH2 X;  2OZ2 A;  4MZO A;  3ERV A;  4Q8G A;  4BS6 A;  4D8I A;  2FQ9 A;  3S3R A;  1TLO A;  1MEM A;  1GCB A;  2FRQ A;  5JH3 A;  3IOQ A;  2BTW B;  3MHS A;  4MSX A;  2DZY A;  5EZS A;  2B1N A;  3WXG A;  3HHA A;  2DC6 A;  1QMY A;  3PHW A;  1X9Y A;  3PW3 A;  1MDW A;  3P5U A;  5KO3 A;  1EWP A;  3BY4 A;  3E9S A;  4XR7 A;  2GHU A;  2YJB A;  2BDL A;  4P16 A;  2E03 A;  2Y6E A;  2ATO A;  3QSD A;  2BTW A;  3IMA A;  2HD5 A;  1XKG A;  4BOS A;  4BPV A;  4K7C A;  5CHT A;  4RY2 A;  2E02 A;  4YYW A;  2IPP B;  3H8B A;  2E00 A;  1YZB A;  2DOS A;  4WUR A;  2G8E A;  3HD3 A;  1DKI A;  5JA7 A;  3V6C A;  4ZUX U;  4YVA A;  1PPN A;  4R3D A;  1ATK A;  3KW9 A;  4RF1 A;  2C0Y A;  1F29 A;  1QOL A;  3BB7 A;  2FTD A;  2DJF B;  3H7D A; 
#chains in the Genus database with same CATH homology
 4AXL A;  3P5V A;  1YVB A;  3B79 A;  1EWO A;  1DF0 A;  5CVN B;  2P7U A;  4P6E A;  1JQP A;  4Q8H A;  3S3Q A;  1U9V A;  1AEC A;  2VFB A;  4CZW A;  1CVZ A;  1ZIV A;  1AU3 A;  3N4C A;  2IBI A;  3M99 A;  2AUX A;  2R9F A;  2YJ2 A;  2JQG R;  3H6S A;  1KHP A;  3K24 A;  1VJV A;  2XU5 A;  1F2B A;  1U5I A;  3K9M A;  4I05 A;  2R9M A;  3BPF A;  4I04 A;  3MOR A;  1M6D A;  3KX1 A;  1U9X A;  3OIS A;  1YT7 A;  2DC8 A;  2OP3 A;  3QJ3 A;  3D6S A;  4BQV A;  2NQG A;  3D9W A;  3PNR A;  3U8E A;  4YYR A;  3IUT A;  2G7Y A;  2F1G A;  8PCH A;  2AU1 A;  5CVM A;  3OVZ A;  1W4T A;  4N8W A;  4CDD B;  4YYV A;  2DCC A;  2Y5B A;  1TL9 A;  3NHE A;  4QBB A;  1ME3 A;  1PE6 A;  1YK7 A;  4PI3 A;  1YK8 A;  1FH0 A;  1U9Q X;  4YYQ A;  5PAD A;  2PBH A;  2XU4 A;  1PPO A;  3H8C A;  2PRE A;  2FYE A;  4FIP A;  1KXR A;  1PCI A;  1CSB B;  1SNK A;  3AI8 A;  2E01 A;  1ITO A;  1PAD A;  3MHH A;  1EWL A;  3HHI A;  4FJC A;  4P6G A;  3DF0 A;  1PIP A;  2CIO A;  3ZUA A;  3K8U A;  3KWB X;  1NLJ A;  3I3T A;  2P0R A;  1KFU L;  1EF7 A;  4YV8 A;  3RVX A;  2NQD B;  1GMY A;  4CDC B;  4DMY A;  4G54 A;  1PBH A;  1AIM A;  2R9C A;  1STF E;  1KHQ A;  1BGO A;  3F5V A;  3CBJ A;  1TU6 A;  3CBK A;  4W5B A;  4AXM A;  1QDQ A;  9PAP A;  4PAD A;  4XUI A;  3N3K A;  5J94 A;  3PDF A;  1CPJ A;  4BSQ A;  2NQA A;  1K3B B;  1IWD A;  4BS5 A;  2PAD A;  7PCK A;  3OVX A;  1AYU A;  3USV A;  2ARY A;  2CB5 A;  3MTN A;  1A6R A;  3TNX A;  2OUL A;  1QXP A;  2BSZ A;  1KFX L;  3BOW A;  2HH5 A;  1MIR A;  3BWK A;  3BPM A;  1AYV A;  4OEM A;  3P5X A;  2P86 A;  2YJC A;  3KFQ A;  4W4U A;  1YAL A;  1CB5 A;  4X6H A;  2DC7 A;  1ME4 A;  1F2A A;  4NV8 A;  4PP2 E;  1THE A;  2AS8 A;  1GX3 A;  2AYN A;  3LFY A;  2B1M A;  2AVW A;  2G8J A;  3IV2 A;  1Y08 A;  2PNS A;  4DMX A;  1S4V A;  3KKU A;  1SP4 B;  1Y4H A;  3P5W A;  1NB3 A;  2R9O A;  1O0E A;  4X6J A;  4YYU A;  3N3G A;  2ACT A;  3V6E A;  4I07 A;  2BDZ A;  4N79 A;  2FUD A;  2YJ9 A;  2O6X A;  1ZCM A;  1HUC B;  4N4Z A;  3CH3 X;  2YJ8 A;  1AYW A;  4QRX A;  5CVO B;  1AU4 A;  4GUZ A;  2FO5 A;  3PBH A;  1CV8 A;  3IEJ A;  3IHP A;  1AU0 A;  2FRA A;  3KWZ A;  3WXF A;  2AYO A;  1POP A;  2FT2 A;  2R6N A;  4OEL A;  1EWM A;  1PPD A;  5K16 A;  4QRG A;  1NB5 A;  2VHF A;  4QH6 A;  2DCA A;  2AIM A;  3OF8 A;  1E2T A;  6PAD A;  1F2C A;  3H89 A;  1DEU A;  2XU1 A;  2DZZ A;  2H7J A;  1MS6 A;  1PXV A;  1CTE A;  3WXE A;  3OF9 A;  2DCB A;  2WBF X;  3I06 A;  4NV7 A;  1BQI A;  1BY8 A;  3O0U A;  4B55 A;  4FK5 A;  1GEC E;  1CJL A;  1BP4 A;  4KLB A;  5EGW A;  3E1Z B;  1MEG A;  4PP1 A;  2NQI A;  2DCD A;  3C9E A;  1W6F A;  3LXS A;  4X6I A;  1AU2 A;  1NL6 A;  2DJG B;  1GLO A;  2G6D A;  4YYS A;  3F75 A;  2R9N A;  3KSE A;  3HWN A;  2XU3 A;  4WA6 A;  2VFC A;  2AUZ A;  3O1G A;  1ICF A;  3RVV A;  5A24 A;  2JQF R;  4CDF B;  5F02 A;  2VHS A;  4W5C A;  4MZS A;  1PPP A;  1NPZ A;  5EF4 A;  4HWY A;  5FPW A;  3BCN A;  4CDE B;  3BC3 A;  5CHV A;  1CS8 A;  3QT4 A;  4QRV A;  2HHN A;  3RVW A;  1CQD A;  3GCB A;  1W5R A;  2GFO A;  2HXZ A;  1U9W A;  1MHW A;  1Q6K A;  2F7D A;  1VSN A;  1NQC A;  2DC9 A;  3CH2 X;  2OZ2 A;  4MZO A;  3ERV A;  4Q8G A;  3LTW A;  4BS6 A;  2FQ9 A;  3S3R A;  1TLO A;  1MEM A;  1GCB A;  2FRQ A;  5JH3 A;  3IOQ A;  3MHS A;  4MSX A;  2DZY A;  2B1N A;  3WXG A;  3HHA A;  2DC6 A;  1QMY A;  1X9Y A;  3PW3 A;  1MDW A;  3P5U A;  1EWP A;  4XR7 A;  2GHU A;  2YJB A;  2BDL A;  2E03 A;  2Y6E A;  2ATO A;  3QSD A;  3IMA A;  2HD5 A;  1XKG A;  4BPV A;  4K7C A;  5CHT A;  4RY2 A;  2E02 A;  4YYW A;  2IPP B;  3H8B A;  2E00 A;  4C5P A;  2G8E A;  3HD3 A;  5JA7 A;  3V6C A;  4ZUX U;  4YVA A;  1PPN A;  1ATK A;  3KW9 A;  2C0Y A;  1F29 A;  1QOL A;  2FTD A;  4BGF A;  2DJF B;  3H7D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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