2XU5A

Cathepsin l with a nitrile inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
220
structure length
216
Chain Sequence
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords CATHEPSIN L1
total genus 67
structure length 216
sequence length 220
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 2xu5A00
3CBJA 4YVAA 2XU3A 1ZCMA 1GLOA 1AYUA 1QMYA 1AU0A 1KFUL 4MZSA 4PP1A 2P86A 3N4CA 1VSNA 2FO5A 4RY2A 4XUIA 1QDQA 3KX1A 3RVVA 4YYWA 1MHWA 2GHUA 4BQVA 4CDDB 2R6NA 2XU1A 1K3BB 1MDWA 4PP2E 4QRGA 3USVA 3B79A 1TLOA 2G8JA 2YJ9A 3WXEA 4K7CA 3KSEA 4G54A 3K8UA 3BOWA 2FQ9A 1AECA 4WA6A 2AIMA 4P6EA 3N3GA 4Q8GA 2DZZA 2AS8A 2ARYA 5CHVA 1S4VA 3HHIA 3RVXA 4YYVA 3PDFA 1U5IA 1GCBA 4QRVA 1PIPA 4KLBA 2R9MA 3K24A 3KFQA 1FH0A 2DJFB 3BPMA 3KW9A 4X6JA 2E01A 4DMXA 1CSBB 1A6RA 1KHPA 1PADA 3WXGA 2DC9A 3KWZA 2AUZA 2DCAA 4AXMA 4CDFB 2Y5BA 3P5XA 3U8EA 4YYUA 2YJ8A 3RVWA 4DMYA 2E00A 2HXZA 1SP4B 2AYOA 2CB5A 3KKUA 3P5VA 2FT2A 1NQCA 5EGWA 1MEMA 2PBHA 9PAPA 1ICFA 5FPWA 5JH3A 1QOLA 3O1GA 1CV8A 2H7JA 2G6DA 3BWKA 1KXRA 2FRAA 3O0UA 2G8EA 3S3QA 3OISA 2NQAA 4CZWA 3MHSA 1X9YA 1ME4A 3QJ3A 2OZ2A 3H7DA 4W4UA 2ATOA 1MEGA 1YT7A 8PCHA 1YK7A 1AYWA 3HWNA 5A24A 4AXLA 1PBHA 1TU6A 2Y6EA 5EF4A 2AYNA 1PPOA 1VJVA 3OVZA 2R9OA 3HHAA 3I06A 2WBFX 4YV8A 3K9MA 1F2AA 2DCCA 5PADA 4W5CA 2E02A 5JA7A 1F29A 3IV2A 3HD3A 1THEA 4I07A 2JQFR 2BDZA 1AU4A 1NPZA 2HD5A 1CB5A 1JQPA 5J94A 1ATKA 2AU1A 1F2BA 4BSQA 3WXFA 2DC8A 2DCDA 1U9XA 2YJCA 2F7DA 1BY8A 5CHTA 3I3TA 3H8BA 1XKGA 2PNSA 2DZYA 2G7YA 4OELA 1Y08A 3OF8A 4N79A 3OF9A 3GCBA 3H8CA 4X6HA 3P5WA 4OEMA 4FK5A 3M99A 3PW3A 1AU3A 1EF7A 1MIRA 2NQDB 2CIOA 1AU2A 1PPNA 4YYRA 1CS8A 2GFOA 1BP4A 1STFE 6PADA 2HHNA 4N4ZA 4PI3A 2PADA 1IWDA 3E1ZB 3PBHA 5K16A 3ERVA 4MSXA 2ACTA 2C0YA 2FUDA 2FRQA 4BS6A 3LXSA 2XU5A 1KHQA 1KFXL 1EWPA 4FJCA 2BDLA 3ZUAA 2O6XA 4YYSA 2FYEA 4QH6A 4Q8HA 4W5BA 1PXVA 4I05A 2AUXA 5CVOB 1YALA 3CH2X 1U9VA 1SNKA 2DCBA 3CH3X 4HWYA 4N8WA 2DC7A 1PCIA 1EWLA 4BS5A 4PADA 3NHEA 1CVZA 3AI8A 2IPPB 1DF0A 2VHFA 3CBKA 2NQIA 1M6DA 3F5VA 3IOQA 2NQGA 1CPJA 3D6SA 1CTEA 1PPDA 3F75A 1PE6A 1YK8A 2F1GA 3S3RA 2R9CA 1YVBA 1O0EA 3IUTA 2OULA 4MZOA 4I04A 1PPPA 1NB5A 1QXPA 1ME3A 1BQIA 2DJGB 2E03A 1U9QX 4YYQA 2JQGR 1ITOA 1CJLA 2P7UA 3IHPA 3TNXA 3H6SA 1HUCB 5CVMA 4P6GA 3MTNA 1Q6KA 3H89A 1NLJA 1DEUA 4QRXA 1MS6A 3OVXA 1AYVA 2R9NA 2AVWA 3MORA 2B1NA 1POPA 3N3KA 3BCNA 3C9EA 1NB3A 3LFYA 1TL9A 3KWBX 4X6IA 2VHSA 7PCKA 1BGOA 1NL6A 1GECE 2FTDA 4CDCB 4QBBA 2XU4A 2YJ2A 3MHHA 5F02A 5CVNB 4CDEB 3BPFA 1F2CA 2HH5A 3QSDA 1ZIVA 3P5UA 3QT4A 1Y4HA 3V6CA 4BPVA 2IBIA 1GMYA 4ZUXU 2DC6A 2OP3A 1CQDA 4XR7A 3BC3A 1U9WA 2R9FA 3DF0A 2P0RA 2PREA 4FIPA 3IEJA 3V6EA 1EWMA 3PNRA 2YJBA 3IMAA 2B1MA 1EWOA 1AIMA
chains in the Genus database with same CATH superfamily
3CBJA 4YVAA 4P16A 2XU3A 1ZCMA 1GLOA 1AYUA 3MJ5A 2FE8A 1QMYA 1AU0A 1KFUL 4MZSA 4OVZB 4BOSA 4PP1A 2P86A 3N4CA 1VSNA 2FO5A 4RY2A 4XUIA 1QDQA 3KX1A 3RVVA 4YYWA 1MHWA 2GHUA 4BQVA 4CDDB 2R6NA 2XU1A 1K3BB 1MDWA 4PP2E 4QRGA 3USVA 3B79A 1TLOA 2JTCA 2G8JA 4RKXA 2YJ9A 3WXEA 2J7QC 4D8IA 4K7CA 3KSEA 4G54A 3K8UA 3BOWA 2FQ9A 1AECA 4WA6A 2AIMA 4P6EA 3N3GA 4Q8GA 4BOZA 2DZZA 2AS8A 4WURA 2ARYA 5CHVA 1S4VA 4RF0A 3HHIA 3RVXA 4YYVA 3PDFA 1U5IA 1GCBA 4QRVA 1PIPA 4KLBA 2R9MA 3K24A 3KFQA 1FH0A 4MI7A 2DJFB 4R3DA 3BPMA 3KW9A 4X6JA 2E01A 4DMXA 1CSBB 1A6RA 1KHPA 1PADA 3WXGA 2DC9A 2UZJA 3ZNHA 3PHUA 3KWZA 2AUZA 2DCAA 3PHXA 4AXMA 4CDFB 2Y5BA 3P5XA 3U8EA 4YYUA 2YJ8A 3RVWA 4DMYA 2E00A 2HXZA 1SP4B 2AYOA 2CB5A 3KKUA 3P5VA 3W30A 2FT2A 1NQCA 5EGWA 1MEMA 2PBHA 9PAPA 1ICFA 3C0RA 5FPWA 5JH3A 1QOLA 4RNAA 3O1GA 1CV8A 2H7JA 2G6DA 3BWKA 1KXRA 2FRAA 3O0UA 3PRPA 2G8EA 3S3QA 3OISA 2NQAA 4CZWA 3PT2A 3MHSA 4D8EA 1X9YA 4RF1A 5KO3A 1ME4A 3QJ3A 2OZ2A 3H7DA 3MP2A 4W4UA 2ATOA 4BOUA 2HWKA 1MEGA 1YT7A 8PCHA 3OQCA 1YK7A 1AYWA 3HWNA 5A24A 4AXLA 3B21A 1PBHA 1TU6A 2Y6EA 5EF4A 2AYNA 1PPOA 1VJVA 3OVZA 2R9OA 3HHAA 3I06A 2WBFX 4YV8A 3K9MA 1F2AA 2DCCA 5PADA 4REZA 4W5CA 2E02A 1PVJA 5JA7A 1F29A 3IV2A 3HD3A 1THEA 4I07A 2JQFR 2BDZA 1AU4A 1NPZA 2HD5A 3PSEA 1CB5A 2AGAA 3O65A 1JQPA 5J94A 1ATKA 2AU1A 1F2BA 4BSQA 4D8BA 3WXFA 2DC8A 2DCDA 1U9XA 2BTWB 4OW0A 2YJCA 2F7DA 1BY8A 3E9SA 5CHTA 3I3TA 3H8BA 1XKGA 2PNSA 2DZYA 2G7YA 4OELA 1Y08A 3OF8A 4N79A 3OF9A 3GCBA 3H8CA 4X6HA 3P5WA 4OEMA 4FK5A 3M99A 4IUMA 4XZXA 3PW3A 1AU3A 1EF7A 1MIRA 2NQDB 3TRKA 2CIOA 1AU2A 1PPNA 2Z84A 4YYRA 1CS8A 1YZBA 2GFOA 1BP4A 1STFE 6PADA 2HHNA 4N4ZA 4PI3A 2JRIA 2PADA 1IWDA 3E1ZB 3PBHA 5K16A 3ERVA 4MSXA 2ACTA 4MM3B 2C0YA 2FUDA 3MTVA 4HXDB 2FRQA 4BS6A 3LXSA 2XU5A 1KHQA 1KFXL 1EWPA 4FJCA 2BDLA 3ZUAA 2O6XA 2BTWA 4YYSA 2FYEA 2J7QA 1DKIA 4QH6A 4Q8HA 4W5BA 1PXVA 4I05A 2AUXA 2DOSA 5CVOB 1YALA 3CH2X 1U9VA 3BB7A 1SNKA 2DCBA 3CH3X 4HWYA 4M0WA 4N8WA 2DC7A 3PHWA 1PCIA 1EWLA 4BS5A 4PADA 3NHEA 1CVZA 3AI8A 1UKFA 2IPPB 4BOQA 1DF0A 5EZQA 2VHFA 3CBKA 2NQIA 1M6DA 3F5VA 3IOQA 2NQGA 1CPJA 3D6SA 1CTEA 1PPDA 3F75A 1PE6A 1YK8A 2F1GA 3S3RA 2R9CA 3BBAA 4PT5A 1YVBA 1O0EA 3IUTA 2OULA 4MZOA 4I04A 1PPPA 1NB5A 1QXPA 1ME3A 1BQIA 2DJGB 3W31A 2E03A 1U9QX 3IFUA 4YYQA 2JQGR 1ITOA 1CJLA 2P7UA 3IHPA 4IP3A 3TNXA 3H6SA 1HUCB 5CVMA 4P6GA 3MTNA 1Q6KA 3H89A 1NLJA 1DEUA 4QRXA 1MS6A 3OVXA 4ZTBA 1AYVA 2R9NA 2AVWA 3MORA 2B1NA 1POPA 3N3KA 3BCNA 3C9EA 1NB3A 3LFYA 4OVZA 1TL9A 3KWBX 4X6IA 4A5UA 2VHSA 4BOPA 2BU3A 7PCKA 1BGOA 1NL6A 1GECE 2FTDA 5EZSA 3PRMA 4CDCB 4QBBA 2XU4A 2YJ2A 3MHHA 5F02A 5CVNB 4CDEB 3BPFA 1F2CA 2HH5A 3TMPA 3QSDA 1ZIVA 3P5UA 3QT4A 1Y4HA 3V6CA 3BY4A 3RNVA 4BPVA 2IBIA 4GUAA 1GMYA 4ZUXU 2DC6A 2OP3A 5JZEA 1CQDA 4XR7A 5E6JA 3BC3A 1U9WA 2R9FA 3DF0A 2P0RA 2PREA 4FIPA 3IEJA 3V6EA 1EWMA 3PNRA 2YJBA 3IMAA 2B1MA 1EWOA 1AIMA
chains in the Genus database with same CATH topology
3CBJA 4BGFA 4YVAA 2XU3A 1ZCMA 1GLOA 4C5PA 1AYUA 1QMYA 1AU0A 1KFUL 4MZSA 4PP1A 2P86A 3N4CA 1VSNA 2FO5A 4RY2A 4XUIA 1QDQA 3KX1A 3RVVA 4YYWA 1MHWA 2GHUA 4BQVA 4CDDB 2R6NA 2XU1A 1K3BB 1MDWA 4PP2E 4QRGA 3USVA 3B79A 1TLOA 2G8JA 2YJ9A 3WXEA 4K7CA 3KSEA 4G54A 3K8UA 3BOWA 2FQ9A 1AECA 4NV7A 4WA6A 2AIMA 4P6EA 3N3GA 4GUZA 4Q8GA 2DZZA 2AS8A 2ARYA 5CHVA 1S4VA 3HHIA 3RVXA 4YYVA 3PDFA 1U5IA 1GCBA 4QRVA 1PIPA 4KLBA 2R9MA 3K24A 3KFQA 1W6FA 1FH0A 2DJFB 3BPMA 3KW9A 4X6JA 2E01A 4DMXA 1CSBB 1A6RA 1KHPA 1PADA 3WXGA 2DC9A 3KWZA 2AUZA 2DCAA 4AXMA 4CDFB 2Y5BA 3P5XA 3U8EA 4YYUA 2YJ8A 3RVWA 4DMYA 2E00A 2HXZA 1SP4B 2AYOA 2CB5A 3KKUA 3P5VA 2FT2A 1NQCA 5EGWA 2VFBA 1MEMA 2PBHA 9PAPA 1ICFA 5FPWA 5JH3A 1QOLA 3O1GA 1CV8A 2H7JA 2G6DA 3BWKA 1KXRA 1W5RA 2FRAA 3O0UA 2G8EA 3S3QA 3OISA 2NQAA 4CZWA 3MHSA 1X9YA 1ME4A 3QJ3A 2OZ2A 3H7DA 4W4UA 2ATOA 1MEGA 1YT7A 8PCHA 1YK7A 1AYWA 3HWNA 5A24A 4AXLA 1PBHA 1TU6A 2Y6EA 5EF4A 2AYNA 2VFCA 1PPOA 1VJVA 3OVZA 2R9OA 3HHAA 3I06A 2WBFX 4YV8A 3K9MA 1F2AA 2DCCA 5PADA 4W5CA 2E02A 5JA7A 1F29A 3IV2A 3HD3A 1THEA 4I07A 2JQFR 2BDZA 1AU4A 1NPZA 4B55A 2HD5A 1CB5A 1JQPA 5J94A 1ATKA 2AU1A 1F2BA 4BSQA 3WXFA 2DC8A 2DCDA 1U9XA 2YJCA 2F7DA 1BY8A 5CHTA 3I3TA 3H8BA 1XKGA 2PNSA 2DZYA 2G7YA 4OELA 1Y08A 3OF8A 4N79A 1E2TA 3OF9A 2BSZA 3GCBA 3H8CA 4X6HA 3P5WA 4OEMA 4FK5A 4NV8A 3M99A 3PW3A 1AU3A 1EF7A 1MIRA 2NQDB 2CIOA 1AU2A 1PPNA 4YYRA 1CS8A 2GFOA 1BP4A 1STFE 6PADA 2HHNA 4N4ZA 4PI3A 2PADA 1IWDA 3E1ZB 3LTWA 3PBHA 5K16A 3ERVA 4MSXA 2ACTA 2C0YA 2FUDA 2FRQA 4BS6A 3LXSA 2XU5A 1KHQA 1KFXL 1EWPA 4FJCA 2BDLA 3ZUAA 2O6XA 4YYSA 2FYEA 4QH6A 4Q8HA 4W5BA 1PXVA 4I05A 2AUXA 5CVOB 1YALA 3CH2X 1U9VA 1SNKA 2DCBA 3CH3X 4HWYA 4N8WA 2DC7A 1PCIA 1EWLA 4BS5A 4PADA 3NHEA 1CVZA 3AI8A 2IPPB 1GX3A 1DF0A 2VHFA 3CBKA 2NQIA 1M6DA 3F5VA 3IOQA 2NQGA 1CPJA 3D6SA 1CTEA 1PPDA 3F75A 1PE6A 1YK8A 2F1GA 3S3RA 2R9CA 1YVBA 1O0EA 3IUTA 2OULA 4MZOA 4I04A 1PPPA 1NB5A 1QXPA 1ME3A 1BQIA 2DJGB 2E03A 1U9QX 4YYQA 2JQGR 1ITOA 1CJLA 2P7UA 3IHPA 3TNXA 3H6SA 1HUCB 5CVMA 4P6GA 3MTNA 1Q6KA 3H89A 1NLJA 1DEUA 4QRXA 1MS6A 3OVXA 1AYVA 2R9NA 2AVWA 3MORA 2B1NA 1POPA 3N3KA 3BCNA 3C9EA 1NB3A 3LFYA 1TL9A 3KWBX 4X6IA 2VHSA 7PCKA 1BGOA 1NL6A 1GECE 2FTDA 4CDCB 4QBBA 2XU4A 2YJ2A 3MHHA 5F02A 5CVNB 4CDEB 3BPFA 1W4TA 1F2CA 2HH5A 3QSDA 1ZIVA 3P5UA 3QT4A 1Y4HA 3V6CA 4BPVA 2IBIA 1GMYA 4ZUXU 2DC6A 2OP3A 1CQDA 4XR7A 3BC3A 1U9WA 2R9FA 3DF0A 2P0RA 2PREA 4FIPA 3IEJA 3D9WA 3V6EA 1EWMA 3PNRA 2YJBA 3IMAA 2B1MA 1EWOA 1AIMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CBJ A;  4YVA A;  2XU3 A;  1ZCM A;  1GLO A;  1AYU A;  1QMY A;  1AU0 A;  1KFU L;  4MZS A;  4PP1 A;  2P86 A;  3N4C A;  1VSN A;  2FO5 A;  4RY2 A;  4XUI A;  1QDQ A;  3KX1 A;  3RVV A;  4YYW A;  1MHW A;  2GHU A;  4BQV A;  4CDD B;  2R6N A;  2XU1 A;  1K3B B;  1MDW A;  4PP2 E;  4QRG A;  3USV A;  3B79 A;  1TLO A;  2G8J A;  2YJ9 A;  3WXE A;  4K7C A;  3KSE A;  4G54 A;  3K8U A;  3BOW A;  2FQ9 A;  1AEC A;  4WA6 A;  2AIM A;  4P6E A;  3N3G A;  4Q8G A;  2DZZ A;  2AS8 A;  2ARY A;  5CHV A;  1S4V A;  3HHI A;  3RVX A;  4YYV A;  3PDF A;  1U5I A;  1GCB A;  4QRV A;  1PIP A;  4KLB A;  2R9M A;  3K24 A;  3KFQ A;  1FH0 A;  2DJF B;  3BPM A;  3KW9 A;  4X6J A;  2E01 A;  4DMX A;  1CSB B;  1A6R A;  1KHP A;  1PAD A;  3WXG A;  2DC9 A;  3KWZ A;  2AUZ A;  2DCA A;  4AXM A;  4CDF B;  2Y5B A;  3P5X A;  3U8E A;  4YYU A;  2YJ8 A;  3RVW A;  4DMY A;  2E00 A;  2HXZ A;  1SP4 B;  2AYO A;  2CB5 A;  3KKU A;  3P5V A;  2FT2 A;  1NQC A;  5EGW A;  1MEM A;  2PBH A;  9PAP A;  1ICF A;  5FPW A;  5JH3 A;  1QOL A;  3O1G A;  1CV8 A;  2H7J A;  2G6D A;  3BWK A;  1KXR A;  2FRA A;  3O0U A;  2G8E A;  3S3Q A;  3OIS A;  2NQA A;  4CZW A;  3MHS A;  1X9Y A;  1ME4 A;  3QJ3 A;  2OZ2 A;  3H7D A;  4W4U A;  2ATO A;  1MEG A;  1YT7 A;  8PCH A;  1YK7 A;  1AYW A;  3HWN A;  5A24 A;  4AXL A;  1PBH A;  1TU6 A;  2Y6E A;  5EF4 A;  2AYN A;  1PPO A;  1VJV A;  3OVZ A;  2R9O A;  3HHA A;  3I06 A;  2WBF X;  4YV8 A;  3K9M A;  1F2A A;  2DCC A;  5PAD A;  4W5C A;  2E02 A;  5JA7 A;  1F29 A;  3IV2 A;  3HD3 A;  1THE A;  4I07 A;  2JQF R;  2BDZ A;  1AU4 A;  1NPZ A;  2HD5 A;  1CB5 A;  1JQP A;  5J94 A;  1ATK A;  2AU1 A;  1F2B A;  4BSQ A;  3WXF A;  2DC8 A;  2DCD A;  1U9X A;  2YJC A;  2F7D A;  1BY8 A;  5CHT A;  3I3T A;  3H8B A;  1XKG A;  2PNS A;  2DZY A;  2G7Y A;  4OEL A;  1Y08 A;  3OF8 A;  4N79 A;  3OF9 A;  3GCB A;  3H8C A;  4X6H A;  3P5W A;  4OEM A;  4FK5 A;  3M99 A;  3PW3 A;  1AU3 A;  1EF7 A;  1MIR A;  2NQD B;  2CIO A;  1AU2 A;  1PPN A;  4YYR A;  1CS8 A;  2GFO A;  1BP4 A;  1STF E;  6PAD A;  2HHN A;  4N4Z A;  4PI3 A;  2PAD A;  1IWD A;  3E1Z B;  3PBH A;  5K16 A;  3ERV A;  4MSX A;  2ACT A;  2C0Y A;  2FUD A;  2FRQ A;  4BS6 A;  3LXS A;  2XU5 A;  1KHQ A;  1KFX L;  1EWP A;  4FJC A;  2BDL A;  3ZUA A;  2O6X A;  4YYS A;  2FYE A;  4QH6 A;  4Q8H A;  4W5B A;  1PXV A;  4I05 A;  2AUX A;  5CVO B;  1YAL A;  3CH2 X;  1U9V A;  1SNK A;  2DCB A;  3CH3 X;  4HWY A;  4N8W A;  2DC7 A;  1PCI A;  1EWL A;  4BS5 A;  4PAD A;  3NHE A;  1CVZ A;  3AI8 A;  2IPP B;  1DF0 A;  2VHF A;  3CBK A;  2NQI A;  1M6D A;  3F5V A;  3IOQ A;  2NQG A;  1CPJ A;  3D6S A;  1CTE A;  1PPD A;  3F75 A;  1PE6 A;  1YK8 A;  2F1G A;  3S3R A;  2R9C A;  1YVB A;  1O0E A;  3IUT A;  2OUL A;  4MZO A;  4I04 A;  1PPP A;  1NB5 A;  1QXP A;  1ME3 A;  1BQI A;  2DJG B;  2E03 A;  1U9Q X;  4YYQ A;  2JQG R;  1ITO A;  1CJL A;  2P7U A;  3IHP A;  3TNX A;  3H6S A;  1HUC B;  5CVM A;  4P6G A;  3MTN A;  1Q6K A;  3H89 A;  1NLJ A;  1DEU A;  4QRX A;  1MS6 A;  3OVX A;  1AYV A;  2R9N A;  2AVW A;  3MOR A;  2B1N A;  1POP A;  3N3K A;  3BCN A;  3C9E A;  1NB3 A;  3LFY A;  1TL9 A;  3KWB X;  4X6I A;  2VHS A;  7PCK A;  1BGO A;  1NL6 A;  1GEC E;  2FTD A;  4CDC B;  4QBB A;  2XU4 A;  2YJ2 A;  3MHH A;  5F02 A;  5CVN B;  4CDE B;  3BPF A;  1F2C A;  2HH5 A;  3QSD A;  1ZIV A;  3P5U A;  3QT4 A;  1Y4H A;  3V6C A;  4BPV A;  2IBI A;  1GMY A;  4ZUX U;  2DC6 A;  2OP3 A;  1CQD A;  4XR7 A;  3BC3 A;  1U9W A;  2R9F A;  3DF0 A;  2P0R A;  2PRE A;  4FIP A;  3IEJ A;  3V6E A;  1EWM A;  3PNR A;  2YJB A;  3IMA A;  2B1M A;  1EWO A;  1AIM A; 
#chains in the Genus database with same CATH topology
 3CBJ A;  4YVA A;  4P16 A;  2XU3 A;  1ZCM A;  1GLO A;  1AYU A;  3MJ5 A;  2FE8 A;  1QMY A;  1AU0 A;  1KFU L;  4MZS A;  4OVZ B;  4BOS A;  4PP1 A;  2P86 A;  3N4C A;  1VSN A;  2FO5 A;  4RY2 A;  4XUI A;  1QDQ A;  3KX1 A;  3RVV A;  4YYW A;  1MHW A;  2GHU A;  4BQV A;  4CDD B;  2R6N A;  2XU1 A;  1K3B B;  1MDW A;  4PP2 E;  4QRG A;  3USV A;  3B79 A;  1TLO A;  2JTC A;  2G8J A;  4RKX A;  2YJ9 A;  3WXE A;  2J7Q C;  4D8I A;  4K7C A;  3KSE A;  4G54 A;  3K8U A;  3BOW A;  2FQ9 A;  1AEC A;  4WA6 A;  2AIM A;  4P6E A;  3N3G A;  4Q8G A;  4BOZ A;  2DZZ A;  2AS8 A;  4WUR A;  2ARY A;  5CHV A;  1S4V A;  4RF0 A;  3HHI A;  3RVX A;  4YYV A;  3PDF A;  1U5I A;  1GCB A;  4QRV A;  1PIP A;  4KLB A;  2R9M A;  3K24 A;  3KFQ A;  1FH0 A;  4MI7 A;  2DJF B;  4R3D A;  3BPM A;  3KW9 A;  4X6J A;  2E01 A;  4DMX A;  1CSB B;  1A6R A;  1KHP A;  1PAD A;  3WXG A;  2DC9 A;  2UZJ A;  3ZNH A;  3PHU A;  3KWZ A;  2AUZ A;  2DCA A;  3PHX A;  4AXM A;  4CDF B;  2Y5B A;  3P5X A;  3U8E A;  4YYU A;  2YJ8 A;  3RVW A;  4DMY A;  2E00 A;  2HXZ A;  1SP4 B;  2AYO A;  2CB5 A;  3KKU A;  3P5V A;  3W30 A;  2FT2 A;  1NQC A;  5EGW A;  1MEM A;  2PBH A;  9PAP A;  1ICF A;  3C0R A;  5FPW A;  5JH3 A;  1QOL A;  4RNA A;  3O1G A;  1CV8 A;  2H7J A;  2G6D A;  3BWK A;  1KXR A;  2FRA A;  3O0U A;  3PRP A;  2G8E A;  3S3Q A;  3OIS A;  2NQA A;  4CZW A;  3PT2 A;  3MHS A;  4D8E A;  1X9Y A;  4RF1 A;  5KO3 A;  1ME4 A;  3QJ3 A;  2OZ2 A;  3H7D A;  3MP2 A;  4W4U A;  2ATO A;  4BOU A;  2HWK A;  1MEG A;  1YT7 A;  8PCH A;  3OQC A;  1YK7 A;  1AYW A;  3HWN A;  5A24 A;  4AXL A;  3B21 A;  1PBH A;  1TU6 A;  2Y6E A;  5EF4 A;  2AYN A;  1PPO A;  1VJV A;  3OVZ A;  2R9O A;  3HHA A;  3I06 A;  2WBF X;  4YV8 A;  3K9M A;  1F2A A;  2DCC A;  5PAD A;  4REZ A;  4W5C A;  2E02 A;  1PVJ A;  5JA7 A;  1F29 A;  3IV2 A;  3HD3 A;  1THE A;  4I07 A;  2JQF R;  2BDZ A;  1AU4 A;  1NPZ A;  2HD5 A;  3PSE A;  1CB5 A;  2AGA A;  3O65 A;  1JQP A;  5J94 A;  1ATK A;  2AU1 A;  1F2B A;  4BSQ A;  4D8B A;  3WXF A;  2DC8 A;  2DCD A;  1U9X A;  2BTW B;  4OW0 A;  2YJC A;  2F7D A;  1BY8 A;  3E9S A;  5CHT A;  3I3T A;  3H8B A;  1XKG A;  2PNS A;  2DZY A;  2G7Y A;  4OEL A;  1Y08 A;  3OF8 A;  4N79 A;  3OF9 A;  3GCB A;  3H8C A;  4X6H A;  3P5W A;  4OEM A;  4FK5 A;  3M99 A;  4IUM A;  4XZX A;  3PW3 A;  1AU3 A;  1EF7 A;  1MIR A;  2NQD B;  3TRK A;  2CIO A;  1AU2 A;  1PPN A;  2Z84 A;  4YYR A;  1CS8 A;  1YZB A;  2GFO A;  1BP4 A;  1STF E;  6PAD A;  2HHN A;  4N4Z A;  4PI3 A;  2JRI A;  2PAD A;  1IWD A;  3E1Z B;  3PBH A;  5K16 A;  3ERV A;  4MSX A;  2ACT A;  4MM3 B;  2C0Y A;  2FUD A;  3MTV A;  4HXD B;  2FRQ A;  4BS6 A;  3LXS A;  2XU5 A;  1KHQ A;  1KFX L;  1EWP A;  4FJC A;  2BDL A;  3ZUA A;  2O6X A;  2BTW A;  4YYS A;  2FYE A;  2J7Q A;  1DKI A;  4QH6 A;  4Q8H A;  4W5B A;  1PXV A;  4I05 A;  2AUX A;  2DOS A;  5CVO B;  1YAL A;  3CH2 X;  1U9V A;  3BB7 A;  1SNK A;  2DCB A;  3CH3 X;  4HWY A;  4M0W A;  4N8W A;  2DC7 A;  3PHW A;  1PCI A;  1EWL A;  4BS5 A;  4PAD A;  3NHE A;  1CVZ A;  3AI8 A;  1UKF A;  2IPP B;  4BOQ A;  1DF0 A;  5EZQ A;  2VHF A;  3CBK A;  2NQI A;  1M6D A;  3F5V A;  3IOQ A;  2NQG A;  1CPJ A;  3D6S A;  1CTE A;  1PPD A;  3F75 A;  1PE6 A;  1YK8 A;  2F1G A;  3S3R A;  2R9C A;  3BBA A;  4PT5 A;  1YVB A;  1O0E A;  3IUT A;  2OUL A;  4MZO A;  4I04 A;  1PPP A;  1NB5 A;  1QXP A;  1ME3 A;  1BQI A;  2DJG B;  3W31 A;  2E03 A;  1U9Q X;  3IFU A;  4YYQ A;  2JQG R;  1ITO A;  1CJL A;  2P7U A;  3IHP A;  4IP3 A;  3TNX A;  3H6S A;  1HUC B;  5CVM A;  4P6G A;  3MTN A;  1Q6K A;  3H89 A;  1NLJ A;  1DEU A;  4QRX A;  1MS6 A;  3OVX A;  4ZTB A;  1AYV A;  2R9N A;  2AVW A;  3MOR A;  2B1N A;  1POP A;  3N3K A;  3BCN A;  3C9E A;  1NB3 A;  3LFY A;  4OVZ A;  1TL9 A;  3KWB X;  4X6I A;  4A5U A;  2VHS A;  4BOP A;  2BU3 A;  7PCK A;  1BGO A;  1NL6 A;  1GEC E;  2FTD A;  5EZS A;  3PRM A;  4CDC B;  4QBB A;  2XU4 A;  2YJ2 A;  3MHH A;  5F02 A;  5CVN B;  4CDE B;  3BPF A;  1F2C A;  2HH5 A;  3TMP A;  3QSD A;  1ZIV A;  3P5U A;  3QT4 A;  1Y4H A;  3V6C A;  3BY4 A;  3RNV A;  4BPV A;  2IBI A;  4GUA A;  1GMY A;  4ZUX U;  2DC6 A;  2OP3 A;  5JZE A;  1CQD A;  4XR7 A;  5E6J A;  3BC3 A;  1U9W A;  2R9F A;  3DF0 A;  2P0R A;  2PRE A;  4FIP A;  3IEJ A;  3V6E A;  1EWM A;  3PNR A;  2YJB A;  3IMA A;  2B1M A;  1EWO A;  1AIM A; 
#chains in the Genus database with same CATH homology
 3CBJ A;  4BGF A;  4YVA A;  2XU3 A;  1ZCM A;  1GLO A;  4C5P A;  1AYU A;  1QMY A;  1AU0 A;  1KFU L;  4MZS A;  4PP1 A;  2P86 A;  3N4C A;  1VSN A;  2FO5 A;  4RY2 A;  4XUI A;  1QDQ A;  3KX1 A;  3RVV A;  4YYW A;  1MHW A;  2GHU A;  4BQV A;  4CDD B;  2R6N A;  2XU1 A;  1K3B B;  1MDW A;  4PP2 E;  4QRG A;  3USV A;  3B79 A;  1TLO A;  2G8J A;  2YJ9 A;  3WXE A;  4K7C A;  3KSE A;  4G54 A;  3K8U A;  3BOW A;  2FQ9 A;  1AEC A;  4NV7 A;  4WA6 A;  2AIM A;  4P6E A;  3N3G A;  4GUZ A;  4Q8G A;  2DZZ A;  2AS8 A;  2ARY A;  5CHV A;  1S4V A;  3HHI A;  3RVX A;  4YYV A;  3PDF A;  1U5I A;  1GCB A;  4QRV A;  1PIP A;  4KLB A;  2R9M A;  3K24 A;  3KFQ A;  1W6F A;  1FH0 A;  2DJF B;  3BPM A;  3KW9 A;  4X6J A;  2E01 A;  4DMX A;  1CSB B;  1A6R A;  1KHP A;  1PAD A;  3WXG A;  2DC9 A;  3KWZ A;  2AUZ A;  2DCA A;  4AXM A;  4CDF B;  2Y5B A;  3P5X A;  3U8E A;  4YYU A;  2YJ8 A;  3RVW A;  4DMY A;  2E00 A;  2HXZ A;  1SP4 B;  2AYO A;  2CB5 A;  3KKU A;  3P5V A;  2FT2 A;  1NQC A;  5EGW A;  2VFB A;  1MEM A;  2PBH A;  9PAP A;  1ICF A;  5FPW A;  5JH3 A;  1QOL A;  3O1G A;  1CV8 A;  2H7J A;  2G6D A;  3BWK A;  1KXR A;  1W5R A;  2FRA A;  3O0U A;  2G8E A;  3S3Q A;  3OIS A;  2NQA A;  4CZW A;  3MHS A;  1X9Y A;  1ME4 A;  3QJ3 A;  2OZ2 A;  3H7D A;  4W4U A;  2ATO A;  1MEG A;  1YT7 A;  8PCH A;  1YK7 A;  1AYW A;  3HWN A;  5A24 A;  4AXL A;  1PBH A;  1TU6 A;  2Y6E A;  5EF4 A;  2AYN A;  2VFC A;  1PPO A;  1VJV A;  3OVZ A;  2R9O A;  3HHA A;  3I06 A;  2WBF X;  4YV8 A;  3K9M A;  1F2A A;  2DCC A;  5PAD A;  4W5C A;  2E02 A;  5JA7 A;  1F29 A;  3IV2 A;  3HD3 A;  1THE A;  4I07 A;  2JQF R;  2BDZ A;  1AU4 A;  1NPZ A;  4B55 A;  2HD5 A;  1CB5 A;  1JQP A;  5J94 A;  1ATK A;  2AU1 A;  1F2B A;  4BSQ A;  3WXF A;  2DC8 A;  2DCD A;  1U9X A;  2YJC A;  2F7D A;  1BY8 A;  5CHT A;  3I3T A;  3H8B A;  1XKG A;  2PNS A;  2DZY A;  2G7Y A;  4OEL A;  1Y08 A;  3OF8 A;  4N79 A;  1E2T A;  3OF9 A;  2BSZ A;  3GCB A;  3H8C A;  4X6H A;  3P5W A;  4OEM A;  4FK5 A;  4NV8 A;  3M99 A;  3PW3 A;  1AU3 A;  1EF7 A;  1MIR A;  2NQD B;  2CIO A;  1AU2 A;  1PPN A;  4YYR A;  1CS8 A;  2GFO A;  1BP4 A;  1STF E;  6PAD A;  2HHN A;  4N4Z A;  4PI3 A;  2PAD A;  1IWD A;  3E1Z B;  3LTW A;  3PBH A;  5K16 A;  3ERV A;  4MSX A;  2ACT A;  2C0Y A;  2FUD A;  2FRQ A;  4BS6 A;  3LXS A;  2XU5 A;  1KHQ A;  1KFX L;  1EWP A;  4FJC A;  2BDL A;  3ZUA A;  2O6X A;  4YYS A;  2FYE A;  4QH6 A;  4Q8H A;  4W5B A;  1PXV A;  4I05 A;  2AUX A;  5CVO B;  1YAL A;  3CH2 X;  1U9V A;  1SNK A;  2DCB A;  3CH3 X;  4HWY A;  4N8W A;  2DC7 A;  1PCI A;  1EWL A;  4BS5 A;  4PAD A;  3NHE A;  1CVZ A;  3AI8 A;  2IPP B;  1GX3 A;  1DF0 A;  2VHF A;  3CBK A;  2NQI A;  1M6D A;  3F5V A;  3IOQ A;  2NQG A;  1CPJ A;  3D6S A;  1CTE A;  1PPD A;  3F75 A;  1PE6 A;  1YK8 A;  2F1G A;  3S3R A;  2R9C A;  1YVB A;  1O0E A;  3IUT A;  2OUL A;  4MZO A;  4I04 A;  1PPP A;  1NB5 A;  1QXP A;  1ME3 A;  1BQI A;  2DJG B;  2E03 A;  1U9Q X;  4YYQ A;  2JQG R;  1ITO A;  1CJL A;  2P7U A;  3IHP A;  3TNX A;  3H6S A;  1HUC B;  5CVM A;  4P6G A;  3MTN A;  1Q6K A;  3H89 A;  1NLJ A;  1DEU A;  4QRX A;  1MS6 A;  3OVX A;  1AYV A;  2R9N A;  2AVW A;  3MOR A;  2B1N A;  1POP A;  3N3K A;  3BCN A;  3C9E A;  1NB3 A;  3LFY A;  1TL9 A;  3KWB X;  4X6I A;  2VHS A;  7PCK A;  1BGO A;  1NL6 A;  1GEC E;  2FTD A;  4CDC B;  4QBB A;  2XU4 A;  2YJ2 A;  3MHH A;  5F02 A;  5CVN B;  4CDE B;  3BPF A;  1W4T A;  1F2C A;  2HH5 A;  3QSD A;  1ZIV A;  3P5U A;  3QT4 A;  1Y4H A;  3V6C A;  4BPV A;  2IBI A;  1GMY A;  4ZUX U;  2DC6 A;  2OP3 A;  1CQD A;  4XR7 A;  3BC3 A;  1U9W A;  2R9F A;  3DF0 A;  2P0R A;  2PRE A;  4FIP A;  3IEJ A;  3D9W A;  3V6E A;  1EWM A;  3PNR A;  2YJB A;  3IMA A;  2B1M A;  1EWO A;  1AIM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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