3H8CA

A combined crystallographic and molecular dynamics study of cathepsin-l retro-binding inhibitors (compound 14)
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
220
structure length
214
Chain Sequence
APRSVDWREKGYVTPVKNQGQCGSWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Cathepsin L1
total genus 66
structure length 214
sequence length 220
chains with identical sequence B
ec nomenclature ec 3.4.22.15: Cathepsin L.
pdb deposition date 2009-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3h8cA00
4W5CA 1IWDA 1PXVA 4BPVA 2YJ8A 4RY2A 3WXEA 1F2CA 2ACTA 1ITOA 2GFOA 2PBHA 2E00A 3I06A 3LFYA 3NHEA 3B79A 2DC8A 9PAPA 1QDQA 1CQDA 3P5VA 4PADA 2E01A 4N4ZA 1FH0A 1NB3A 1KXRA 1Y08A 4I04A 2PREA 1YK8A 2ATOA 2DCDA 3H6SA 2G6DA 2OZ2A 2FQ9A 3QJ3A 1NLJA 1VSNA 3BPMA 1TL9A 4QRGA 1YALA 6PADA 3MORA 3HHAA 2JQFR 3N4CA 2WBFX 1AU3A 4QBBA 2CB5A 3HWNA 2Y5BA 1GMYA 4YV8A 4YYUA 2H7JA 5J94A 2R9FA 3KX1A 1MHWA 3M99A 3ERVA 2BDLA 2FRAA 1CSBB 2O6XA 1K3BB 4QRXA 1NQCA 4XUIA 1ATKA 1CB5A 2DC6A 1BP4A 1U9VA 3V6EA 3QT4A 3S3RA 1GECE 3OF9A 1YK7A 4ZUXU 1PADA 4MSXA 1PPNA 1CV8A 1X9YA 3MTNA 1NB5A 1QOLA 4QH6A 3PW3A 1Q6KA 2OULA 4WA6A 3BWKA 3IHPA 2DCBA 4KLBA 3H89A 1BGOA 1S4VA 1U5IA 4P6EA 1YT7A 2AU1A 2R9CA 2BDZA 1VJVA 1KFXL 3O0UA 1GLOA 1MEGA 2AS8A 3H7DA 5K16A 4N8WA 3RVXA 2P86A 4DMXA 4YYRA 1XKGA 3KSEA 2HD5A 4W5BA 1QMYA 3OISA 2AYOA 4W4UA 2NQGA 1PCIA 1F2BA 3CBJA 1TLOA 3N3GA 4HWYA 3KWBX 2R6NA 4CDCB 2G8EA 3C9EA 4PP1A 2F7DA 4DMYA 1PE6A 4OELA 1NL6A 3QSDA 1MEMA 4YVAA 3P5UA 2HH5A 1AYVA 3RVWA 3S3QA 3K9MA 2G7YA 2FTDA 2P0RA 3U8EA 2GHUA 4G54A 5CVNB 2DCCA 4BSQA 1PPDA 4X6IA 4X6JA 2FYEA 1KHQA 1ICFA 2DCAA 2DJGB 2IPPB 1EWPA 2Y6EA 1F29A 2AYNA 4MZSA 3GCBA 2AIMA 1KFUL 1AU4A 5EGWA 1AU2A 1PPOA 1YVBA 7PCKA 2DJFB 4FJCA 8PCHA 4CDDB 2DC9A 2E03A 2F1GA 3AI8A 1JQPA 1EWOA 4X6HA 1PIPA 5CVMA 1ME3A 3LXSA 2PNSA 3D6SA 4Q8GA 2XU4A 2FO5A 4Q8HA 2NQIA 1POPA 1AU0A 3I3TA 4XR7A 5CVOB 3KW9A 2B1NA 2DC7A 1TU6A 3MHSA 3OF8A 3DF0A 1EF7A 1MDWA 1U9QX 1STFE 4YYQA 1CTEA 2YJ2A 1AECA 1HUCB 1GCBA 4I07A 4CDEB 4CZWA 1CPJA 3PBHA 4YYSA 5F02A 4QRVA 4PI3A 1DEUA 4K7CA 3F5VA 4AXLA 3WXFA 1EWLA 1F2AA 2IBIA 3KKUA 3WXGA 2XU1A 5JA7A 5A24A 1U9XA 3IUTA 2DZZA 2JQGR 3P5XA 3N3KA 2HHNA 1AYWA 2C0YA 1BQIA 3H8CA 4PP2E 3CH2X 3USVA 4FIPA 4P6GA 3OVXA 3H8BA 1O0EA 3RVVA 3IMAA 3MHHA 2B1MA 3PNRA 1AIMA 2XU3A 2G8JA 3V6CA 4BS5A 3E1ZB 2ARYA 5CHVA 1AYUA 1BY8A 2AUXA 2FT2A 1EWMA 3F75A 4CDFB 2YJ9A 2R9OA 1Y4HA 1CVZA 4FK5A 1ZIVA 3OVZA 2YJBA 3O1GA 4MZOA 2PADA 2FRQA 1ZCMA 2AVWA 2AUZA 3KFQA 1CJLA 4I05A 1M6DA 2R9MA 3P5WA 2DZYA 5EF4A 3K24A 1NPZA 3IV2A 1KHPA 1THEA 3CH3X 1U9WA 2NQDB 1PBHA 1CS8A 3KWZA 4YYVA 2CIOA 2HXZA 1DF0A 2E02A 5CHTA 1SNKA 3HHIA 3IEJA 2FUDA 1ME4A 4BS6A 2P7UA 1MS6A 1MIRA 3BOWA 2XU5A 2R9NA 3HD3A 2VHFA 4N79A 3IOQA 3BC3A 2VHSA 4BQVA 3BCNA 2OP3A 3TNXA 5FPWA 4YYWA 3BPFA 3K8UA 1SP4B 4OEMA 3ZUAA 1A6RA 1QXPA 2YJCA 2NQAA 4AXMA 1PPPA 3CBKA 3PDFA 5JH3A 5PADA
chains in the Genus database with same CATH superfamily
4W5CA 1IWDA 4XZXA 1PXVA 4BPVA 2YJ8A 4RY2A 5JZEA 3WXEA 1F2CA 2ACTA 1ITOA 2GFOA 2PBHA 2E00A 3I06A 3LFYA 3NHEA 3B79A 2DC8A 9PAPA 1QDQA 1CQDA 3P5VA 4PADA 2E01A 2JRIA 4N4ZA 1FH0A 2BTWB 1NB3A 1KXRA 1Y08A 4I04A 2PREA 1YK8A 2ATOA 2DCDA 4A5UA 3H6SA 4D8EA 2G6DA 2OZ2A 2FQ9A 3IFUA 3QJ3A 1NLJA 1VSNA 4HXDB 3BPMA 1DKIA 1TL9A 4QRGA 4BOUA 1YALA 6PADA 3MORA 3HHAA 2JQFR 3N4CA 3PT2A 2WBFX 1AU3A 4QBBA 2CB5A 3HWNA 2Y5BA 1GMYA 4YV8A 4YYUA 2H7JA 5J94A 4WURA 2R9FA 4BOZA 3KX1A 1MHWA 3M99A 4RF0A 3ERVA 2BDLA 2FRAA 1CSBB 3MJ5A 2O6XA 1K3BB 4QRXA 1UKFA 4BOQA 3TMPA 1NQCA 4R3DA 4XUIA 1ATKA 1CB5A 2DC6A 1BP4A 1U9VA 3BY4A 3V6EA 3QT4A 3S3RA 1GECE 2UZJA 3OF9A 1YK7A 4ZUXU 1PADA 4MSXA 4OVZA 1PPNA 1CV8A 1X9YA 3MTNA 1NB5A 4M0WA 4D8BA 1QOLA 4QH6A 3PW3A 1Q6KA 2OULA 4WA6A 3BWKA 3IHPA 2DCBA 4GUAA 4KLBA 3H89A 1BGOA 1S4VA 1U5IA 4P6EA 1YT7A 2AU1A 3B21A 2R9CA 2BDZA 1VJVA 1KFXL 3O0UA 1GLOA 1MEGA 2AS8A 3H7DA 5K16A 4N8WA 3RVXA 2P86A 2BTWA 4DMXA 3OQCA 4YYRA 4OW0A 1XKGA 3KSEA 2HD5A 3PRPA 4W5BA 1QMYA 4IUMA 3OISA 2AYOA 2Z84A 4W4UA 3TRKA 2HWKA 2NQGA 4PT5A 1PCIA 1F2BA 3CBJA 1TLOA 4P16A 3N3GA 4HWYA 3KWBX 2R6NA 4CDCB 2G8EA 3PHXA 3C9EA 4PP1A 2F7DA 4DMYA 1PE6A 4OELA 3O65A 1NL6A 1YZBA 3QSDA 2JTCA 1MEMA 2FE8A 4YVAA 3P5UA 2HH5A 1AYVA 3C0RA 3RVWA 3S3QA 3PHWA 3K9MA 2G7YA 2FTDA 2P0RA 3U8EA 2GHUA 4G54A 5CVNB 2DCCA 3BB7A 4BSQA 4REZA 1PPDA 4X6IA 4X6JA 2FYEA 4BOSA 1KHQA 1ICFA 3MTVA 2DCAA 2DJGB 2IPPB 1EWPA 2Y6EA 1F29A 2AYNA 4RKXA 4MZSA 3GCBA 2AIMA 1KFUL 1AU4A 5EGWA 1AU2A 1PPOA 1YVBA 7PCKA 2DJFB 3PSEA 4FJCA 8PCHA 3MP2A 4CDDB 2DC9A 2E03A 2F1GA 3AI8A 1JQPA 1EWOA 4X6HA 4MI7A 1PIPA 5CVMA 1ME3A 3LXSA 2PNSA 3D6SA 4Q8GA 5EZQA 2XU4A 2FO5A 4Q8HA 2NQIA 1POPA 1AU0A 3I3TA 4XR7A 5CVOB 3KW9A 2B1NA 4BOPA 4RNAA 5E6JA 2DC7A 1TU6A 2J7QA 3MHSA 3OF8A 3DF0A 1EF7A 1MDWA 1U9QX 1STFE 4YYQA 1PVJA 1CTEA 2YJ2A 1AECA 1HUCB 1GCBA 4I07A 4CDEB 4CZWA 1CPJA 3PBHA 4YYSA 5F02A 4QRVA 4PI3A 1DEUA 4K7CA 3F5VA 4AXLA 5KO3A 3WXFA 3RNVA 1EWLA 1F2AA 2IBIA 3KKUA 3WXGA 2XU1A 5JA7A 5A24A 1U9XA 3PRMA 3IUTA 2DZZA 2JQGR 3P5XA 3N3KA 2HHNA 1AYWA 2C0YA 1BQIA 3H8CA 4PP2E 3CH2X 3USVA 4FIPA 4P6GA 3OVXA 3E9SA 1O0EA 3H8BA 3RVVA 3IMAA 3MHHA 2B1MA 3PNRA 4D8IA 2DOSA 1AIMA 2XU3A 2G8JA 3V6CA 3W31A 4BS5A 3E1ZB 2ARYA 5CHVA 2AGAA 1AYUA 2J7QC 4MM3B 1BY8A 2AUXA 2FT2A 1EWMA 3F75A 4CDFB 2YJ9A 2R9OA 1Y4HA 1CVZA 4FK5A 1ZIVA 3OVZA 2YJBA 3O1GA 4MZOA 2PADA 2FRQA 1ZCMA 2AVWA 2AUZA 3KFQA 1CJLA 4I05A 1M6DA 2R9MA 3P5WA 2DZYA 5EF4A 3K24A 1NPZA 3IV2A 1KHPA 1THEA 3CH3X 1U9WA 2NQDB 4ZTBA 1PBHA 1CS8A 3W30A 3KWZA 4YYVA 2CIOA 2HXZA 1DF0A 2E02A 5CHTA 5EZSA 1SNKA 3HHIA 3IEJA 2FUDA 1ME4A 4RF1A 4BS6A 2P7UA 1MS6A 1MIRA 3BOWA 2XU5A 2R9NA 3ZNHA 3HD3A 2VHFA 4N79A 3IOQA 3BC3A 2VHSA 4BQVA 3BCNA 3BBAA 3PHUA 2OP3A 4IP3A 3TNXA 5FPWA 4YYWA 3BPFA 3K8UA 1SP4B 4OEMA 3ZUAA 1A6RA 4OVZB 1QXPA 2YJCA 2BU3A 2NQAA 4AXMA 1PPPA 3CBKA 3PDFA 5JH3A 5PADA
chains in the Genus database with same CATH topology
4W5CA 1IWDA 1PXVA 4BPVA 2YJ8A 4RY2A 3WXEA 1F2CA 2ACTA 1ITOA 2GFOA 2PBHA 2E00A 3I06A 3LFYA 3NHEA 3B79A 2DC8A 9PAPA 4BGFA 1QDQA 1CQDA 3P5VA 4PADA 2E01A 4N4ZA 1FH0A 1NB3A 1KXRA 1Y08A 4I04A 2PREA 1YK8A 2ATOA 2DCDA 1W5RA 3H6SA 2G6DA 2OZ2A 2FQ9A 3QJ3A 1NLJA 1VSNA 4B55A 3BPMA 1TL9A 4NV8A 4QRGA 1YALA 6PADA 3MORA 3HHAA 2JQFR 3N4CA 2WBFX 1AU3A 4QBBA 2CB5A 3HWNA 2Y5BA 1GMYA 4YV8A 4YYUA 2H7JA 5J94A 2R9FA 3KX1A 4GUZA 1MHWA 3M99A 3ERVA 2BDLA 2FRAA 1CSBB 2O6XA 1K3BB 4QRXA 1W6FA 1NQCA 4XUIA 1ATKA 1CB5A 2DC6A 1BP4A 1U9VA 3V6EA 1GX3A 3QT4A 3S3RA 1GECE 2VFCA 3OF9A 1YK7A 4ZUXU 1PADA 4MSXA 1PPNA 1CV8A 1X9YA 3MTNA 1NB5A 1QOLA 4QH6A 3PW3A 1Q6KA 2OULA 4WA6A 3BWKA 3IHPA 2DCBA 3D9WA 4KLBA 3H89A 1BGOA 1S4VA 1U5IA 4P6EA 1YT7A 2AU1A 2R9CA 2BDZA 1VJVA 1KFXL 3O0UA 1GLOA 1MEGA 2AS8A 3H7DA 5K16A 4N8WA 3RVXA 2P86A 4DMXA 4YYRA 1XKGA 3KSEA 2HD5A 4W5BA 1QMYA 3OISA 2AYOA 4W4UA 2NQGA 1PCIA 1F2BA 3CBJA 1TLOA 3N3GA 4HWYA 3KWBX 2R6NA 4CDCB 2G8EA 3C9EA 4PP1A 2F7DA 4DMYA 1PE6A 4OELA 1NL6A 3QSDA 1MEMA 4YVAA 3P5UA 2HH5A 1AYVA 3RVWA 3S3QA 3K9MA 2G7YA 2FTDA 2P0RA 3U8EA 2GHUA 4G54A 5CVNB 2DCCA 4BSQA 1PPDA 4X6IA 4X6JA 2FYEA 1KHQA 1ICFA 2DCAA 2DJGB 2IPPB 1EWPA 2Y6EA 1F29A 2AYNA 4MZSA 3GCBA 2AIMA 1KFUL 1AU4A 5EGWA 1AU2A 1PPOA 1YVBA 7PCKA 2DJFB 4FJCA 8PCHA 4CDDB 2DC9A 2E03A 2F1GA 3AI8A 1JQPA 1EWOA 4X6HA 1PIPA 5CVMA 1ME3A 3LXSA 2PNSA 3D6SA 4Q8GA 2XU4A 2FO5A 4Q8HA 2NQIA 1POPA 1AU0A 3I3TA 4XR7A 5CVOB 3KW9A 2B1NA 2DC7A 1TU6A 3MHSA 3OF8A 3DF0A 1EF7A 1MDWA 1U9QX 1STFE 4YYQA 1CTEA 2YJ2A 1AECA 1HUCB 1GCBA 4I07A 4CDEB 1E2TA 4CZWA 1CPJA 3PBHA 4YYSA 5F02A 4QRVA 4PI3A 1DEUA 4K7CA 3F5VA 4AXLA 3WXFA 1EWLA 1F2AA 2IBIA 3KKUA 3WXGA 2XU1A 5JA7A 5A24A 1U9XA 3IUTA 2DZZA 2JQGR 3P5XA 3N3KA 2HHNA 1AYWA 2C0YA 4NV7A 1BQIA 3H8CA 4PP2E 3CH2X 3USVA 4FIPA 4P6GA 3OVXA 3H8BA 1O0EA 3RVVA 3IMAA 3MHHA 2B1MA 3PNRA 1AIMA 2XU3A 2G8JA 3V6CA 4BS5A 3E1ZB 1W4TA 2ARYA 5CHVA 1AYUA 1BY8A 2AUXA 2FT2A 1EWMA 3F75A 4CDFB 2VFBA 2YJ9A 2R9OA 1Y4HA 1CVZA 4FK5A 1ZIVA 3OVZA 2YJBA 3O1GA 4MZOA 2PADA 2FRQA 1ZCMA 2AVWA 2AUZA 3KFQA 2BSZA 1CJLA 4I05A 1M6DA 2R9MA 3P5WA 2DZYA 3LTWA 5EF4A 3K24A 1NPZA 3IV2A 1KHPA 1THEA 3CH3X 1U9WA 2NQDB 1PBHA 1CS8A 3KWZA 4YYVA 2CIOA 2HXZA 1DF0A 2E02A 5CHTA 1SNKA 3HHIA 3IEJA 2FUDA 1ME4A 4BS6A 2P7UA 1MS6A 1MIRA 3BOWA 4C5PA 2XU5A 2R9NA 3HD3A 2VHFA 4N79A 3IOQA 3BC3A 2VHSA 4BQVA 3BCNA 2OP3A 3TNXA 5FPWA 4YYWA 3BPFA 3K8UA 1SP4B 4OEMA 3ZUAA 1A6RA 1QXPA 2YJCA 2NQAA 4AXMA 1PPPA 3CBKA 3PDFA 5JH3A 5PADA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4W5C A;  1IWD A;  1PXV A;  4BPV A;  2YJ8 A;  4RY2 A;  3WXE A;  1F2C A;  2ACT A;  1ITO A;  2GFO A;  2PBH A;  2E00 A;  3I06 A;  3LFY A;  3NHE A;  3B79 A;  2DC8 A;  9PAP A;  1QDQ A;  1CQD A;  3P5V A;  4PAD A;  2E01 A;  4N4Z A;  1FH0 A;  1NB3 A;  1KXR A;  1Y08 A;  4I04 A;  2PRE A;  1YK8 A;  2ATO A;  2DCD A;  3H6S A;  2G6D A;  2OZ2 A;  2FQ9 A;  3QJ3 A;  1NLJ A;  1VSN A;  3BPM A;  1TL9 A;  4QRG A;  1YAL A;  6PAD A;  3MOR A;  3HHA A;  2JQF R;  3N4C A;  2WBF X;  1AU3 A;  4QBB A;  2CB5 A;  3HWN A;  2Y5B A;  1GMY A;  4YV8 A;  4YYU A;  2H7J A;  5J94 A;  2R9F A;  3KX1 A;  1MHW A;  3M99 A;  3ERV A;  2BDL A;  2FRA A;  1CSB B;  2O6X A;  1K3B B;  4QRX A;  1NQC A;  4XUI A;  1ATK A;  1CB5 A;  2DC6 A;  1BP4 A;  1U9V A;  3V6E A;  3QT4 A;  3S3R A;  1GEC E;  3OF9 A;  1YK7 A;  4ZUX U;  1PAD A;  4MSX A;  1PPN A;  1CV8 A;  1X9Y A;  3MTN A;  1NB5 A;  1QOL A;  4QH6 A;  3PW3 A;  1Q6K A;  2OUL A;  4WA6 A;  3BWK A;  3IHP A;  2DCB A;  4KLB A;  3H89 A;  1BGO A;  1S4V A;  1U5I A;  4P6E A;  1YT7 A;  2AU1 A;  2R9C A;  2BDZ A;  1VJV A;  1KFX L;  3O0U A;  1GLO A;  1MEG A;  2AS8 A;  3H7D A;  5K16 A;  4N8W A;  3RVX A;  2P86 A;  4DMX A;  4YYR A;  1XKG A;  3KSE A;  2HD5 A;  4W5B A;  1QMY A;  3OIS A;  2AYO A;  4W4U A;  2NQG A;  1PCI A;  1F2B A;  3CBJ A;  1TLO A;  3N3G A;  4HWY A;  3KWB X;  2R6N A;  4CDC B;  2G8E A;  3C9E A;  4PP1 A;  2F7D A;  4DMY A;  1PE6 A;  4OEL A;  1NL6 A;  3QSD A;  1MEM A;  4YVA A;  3P5U A;  2HH5 A;  1AYV A;  3RVW A;  3S3Q A;  3K9M A;  2G7Y A;  2FTD A;  2P0R A;  3U8E A;  2GHU A;  4G54 A;  5CVN B;  2DCC A;  4BSQ A;  1PPD A;  4X6I A;  4X6J A;  2FYE A;  1KHQ A;  1ICF A;  2DCA A;  2DJG B;  2IPP B;  1EWP A;  2Y6E A;  1F29 A;  2AYN A;  4MZS A;  3GCB A;  2AIM A;  1KFU L;  1AU4 A;  5EGW A;  1AU2 A;  1PPO A;  1YVB A;  7PCK A;  2DJF B;  4FJC A;  8PCH A;  4CDD B;  2DC9 A;  2E03 A;  2F1G A;  3AI8 A;  1JQP A;  1EWO A;  4X6H A;  1PIP A;  5CVM A;  1ME3 A;  3LXS A;  2PNS A;  3D6S A;  4Q8G A;  2XU4 A;  2FO5 A;  4Q8H A;  2NQI A;  1POP A;  1AU0 A;  3I3T A;  4XR7 A;  5CVO B;  3KW9 A;  2B1N A;  2DC7 A;  1TU6 A;  3MHS A;  3OF8 A;  3DF0 A;  1EF7 A;  1MDW A;  1U9Q X;  1STF E;  4YYQ A;  1CTE A;  2YJ2 A;  1AEC A;  1HUC B;  1GCB A;  4I07 A;  4CDE B;  4CZW A;  1CPJ A;  3PBH A;  4YYS A;  5F02 A;  4QRV A;  4PI3 A;  1DEU A;  4K7C A;  3F5V A;  4AXL A;  3WXF A;  1EWL A;  1F2A A;  2IBI A;  3KKU A;  3WXG A;  2XU1 A;  5JA7 A;  5A24 A;  1U9X A;  3IUT A;  2DZZ A;  2JQG R;  3P5X A;  3N3K A;  2HHN A;  1AYW A;  2C0Y A;  1BQI A;  3H8C A;  4PP2 E;  3CH2 X;  3USV A;  4FIP A;  4P6G A;  3OVX A;  3H8B A;  1O0E A;  3RVV A;  3IMA A;  3MHH A;  2B1M A;  3PNR A;  1AIM A;  2XU3 A;  2G8J A;  3V6C A;  4BS5 A;  3E1Z B;  2ARY A;  5CHV A;  1AYU A;  1BY8 A;  2AUX A;  2FT2 A;  1EWM A;  3F75 A;  4CDF B;  2YJ9 A;  2R9O A;  1Y4H A;  1CVZ A;  4FK5 A;  1ZIV A;  3OVZ A;  2YJB A;  3O1G A;  4MZO A;  2PAD A;  2FRQ A;  1ZCM A;  2AVW A;  2AUZ A;  3KFQ A;  1CJL A;  4I05 A;  1M6D A;  2R9M A;  3P5W A;  2DZY A;  5EF4 A;  3K24 A;  1NPZ A;  3IV2 A;  1KHP A;  1THE A;  3CH3 X;  1U9W A;  2NQD B;  1PBH A;  1CS8 A;  3KWZ A;  4YYV A;  2CIO A;  2HXZ A;  1DF0 A;  2E02 A;  5CHT A;  1SNK A;  3HHI A;  3IEJ A;  2FUD A;  1ME4 A;  4BS6 A;  2P7U A;  1MS6 A;  1MIR A;  3BOW A;  2XU5 A;  2R9N A;  3HD3 A;  2VHF A;  4N79 A;  3IOQ A;  3BC3 A;  2VHS A;  4BQV A;  3BCN A;  2OP3 A;  3TNX A;  5FPW A;  4YYW A;  3BPF A;  3K8U A;  1SP4 B;  4OEM A;  3ZUA A;  1A6R A;  1QXP A;  2YJC A;  2NQA A;  4AXM A;  1PPP A;  3CBK A;  3PDF A;  5JH3 A;  5PAD A; 
#chains in the Genus database with same CATH topology
 4W5C A;  1IWD A;  4XZX A;  1PXV A;  4BPV A;  2YJ8 A;  4RY2 A;  5JZE A;  3WXE A;  1F2C A;  2ACT A;  1ITO A;  2GFO A;  2PBH A;  2E00 A;  3I06 A;  3LFY A;  3NHE A;  3B79 A;  2DC8 A;  9PAP A;  1QDQ A;  1CQD A;  3P5V A;  4PAD A;  2E01 A;  2JRI A;  4N4Z A;  1FH0 A;  2BTW B;  1NB3 A;  1KXR A;  1Y08 A;  4I04 A;  2PRE A;  1YK8 A;  2ATO A;  2DCD A;  4A5U A;  3H6S A;  4D8E A;  2G6D A;  2OZ2 A;  2FQ9 A;  3IFU A;  3QJ3 A;  1NLJ A;  1VSN A;  4HXD B;  3BPM A;  1DKI A;  1TL9 A;  4QRG A;  4BOU A;  1YAL A;  6PAD A;  3MOR A;  3HHA A;  2JQF R;  3N4C A;  3PT2 A;  2WBF X;  1AU3 A;  4QBB A;  2CB5 A;  3HWN A;  2Y5B A;  1GMY A;  4YV8 A;  4YYU A;  2H7J A;  5J94 A;  4WUR A;  2R9F A;  4BOZ A;  3KX1 A;  1MHW A;  3M99 A;  4RF0 A;  3ERV A;  2BDL A;  2FRA A;  1CSB B;  3MJ5 A;  2O6X A;  1K3B B;  4QRX A;  1UKF A;  4BOQ A;  3TMP A;  1NQC A;  4R3D A;  4XUI A;  1ATK A;  1CB5 A;  2DC6 A;  1BP4 A;  1U9V A;  3BY4 A;  3V6E A;  3QT4 A;  3S3R A;  1GEC E;  2UZJ A;  3OF9 A;  1YK7 A;  4ZUX U;  1PAD A;  4MSX A;  4OVZ A;  1PPN A;  1CV8 A;  1X9Y A;  3MTN A;  1NB5 A;  4M0W A;  4D8B A;  1QOL A;  4QH6 A;  3PW3 A;  1Q6K A;  2OUL A;  4WA6 A;  3BWK A;  3IHP A;  2DCB A;  4GUA A;  4KLB A;  3H89 A;  1BGO A;  1S4V A;  1U5I A;  4P6E A;  1YT7 A;  2AU1 A;  3B21 A;  2R9C A;  2BDZ A;  1VJV A;  1KFX L;  3O0U A;  1GLO A;  1MEG A;  2AS8 A;  3H7D A;  5K16 A;  4N8W A;  3RVX A;  2P86 A;  2BTW A;  4DMX A;  3OQC A;  4YYR A;  4OW0 A;  1XKG A;  3KSE A;  2HD5 A;  3PRP A;  4W5B A;  1QMY A;  4IUM A;  3OIS A;  2AYO A;  2Z84 A;  4W4U A;  3TRK A;  2HWK A;  2NQG A;  4PT5 A;  1PCI A;  1F2B A;  3CBJ A;  1TLO A;  4P16 A;  3N3G A;  4HWY A;  3KWB X;  2R6N A;  4CDC B;  2G8E A;  3PHX A;  3C9E A;  4PP1 A;  2F7D A;  4DMY A;  1PE6 A;  4OEL A;  3O65 A;  1NL6 A;  1YZB A;  3QSD A;  2JTC A;  1MEM A;  2FE8 A;  4YVA A;  3P5U A;  2HH5 A;  1AYV A;  3C0R A;  3RVW A;  3S3Q A;  3PHW A;  3K9M A;  2G7Y A;  2FTD A;  2P0R A;  3U8E A;  2GHU A;  4G54 A;  5CVN B;  2DCC A;  3BB7 A;  4BSQ A;  4REZ A;  1PPD A;  4X6I A;  4X6J A;  2FYE A;  4BOS A;  1KHQ A;  1ICF A;  3MTV A;  2DCA A;  2DJG B;  2IPP B;  1EWP A;  2Y6E A;  1F29 A;  2AYN A;  4RKX A;  4MZS A;  3GCB A;  2AIM A;  1KFU L;  1AU4 A;  5EGW A;  1AU2 A;  1PPO A;  1YVB A;  7PCK A;  2DJF B;  3PSE A;  4FJC A;  8PCH A;  3MP2 A;  4CDD B;  2DC9 A;  2E03 A;  2F1G A;  3AI8 A;  1JQP A;  1EWO A;  4X6H A;  4MI7 A;  1PIP A;  5CVM A;  1ME3 A;  3LXS A;  2PNS A;  3D6S A;  4Q8G A;  5EZQ A;  2XU4 A;  2FO5 A;  4Q8H A;  2NQI A;  1POP A;  1AU0 A;  3I3T A;  4XR7 A;  5CVO B;  3KW9 A;  2B1N A;  4BOP A;  4RNA A;  5E6J A;  2DC7 A;  1TU6 A;  2J7Q A;  3MHS A;  3OF8 A;  3DF0 A;  1EF7 A;  1MDW A;  1U9Q X;  1STF E;  4YYQ A;  1PVJ A;  1CTE A;  2YJ2 A;  1AEC A;  1HUC B;  1GCB A;  4I07 A;  4CDE B;  4CZW A;  1CPJ A;  3PBH A;  4YYS A;  5F02 A;  4QRV A;  4PI3 A;  1DEU A;  4K7C A;  3F5V A;  4AXL A;  5KO3 A;  3WXF A;  3RNV A;  1EWL A;  1F2A A;  2IBI A;  3KKU A;  3WXG A;  2XU1 A;  5JA7 A;  5A24 A;  1U9X A;  3PRM A;  3IUT A;  2DZZ A;  2JQG R;  3P5X A;  3N3K A;  2HHN A;  1AYW A;  2C0Y A;  1BQI A;  3H8C A;  4PP2 E;  3CH2 X;  3USV A;  4FIP A;  4P6G A;  3OVX A;  3E9S A;  1O0E A;  3H8B A;  3RVV A;  3IMA A;  3MHH A;  2B1M A;  3PNR A;  4D8I A;  2DOS A;  1AIM A;  2XU3 A;  2G8J A;  3V6C A;  3W31 A;  4BS5 A;  3E1Z B;  2ARY A;  5CHV A;  2AGA A;  1AYU A;  2J7Q C;  4MM3 B;  1BY8 A;  2AUX A;  2FT2 A;  1EWM A;  3F75 A;  4CDF B;  2YJ9 A;  2R9O A;  1Y4H A;  1CVZ A;  4FK5 A;  1ZIV A;  3OVZ A;  2YJB A;  3O1G A;  4MZO A;  2PAD A;  2FRQ A;  1ZCM A;  2AVW A;  2AUZ A;  3KFQ A;  1CJL A;  4I05 A;  1M6D A;  2R9M A;  3P5W A;  2DZY A;  5EF4 A;  3K24 A;  1NPZ A;  3IV2 A;  1KHP A;  1THE A;  3CH3 X;  1U9W A;  2NQD B;  4ZTB A;  1PBH A;  1CS8 A;  3W30 A;  3KWZ A;  4YYV A;  2CIO A;  2HXZ A;  1DF0 A;  2E02 A;  5CHT A;  5EZS A;  1SNK A;  3HHI A;  3IEJ A;  2FUD A;  1ME4 A;  4RF1 A;  4BS6 A;  2P7U A;  1MS6 A;  1MIR A;  3BOW A;  2XU5 A;  2R9N A;  3ZNH A;  3HD3 A;  2VHF A;  4N79 A;  3IOQ A;  3BC3 A;  2VHS A;  4BQV A;  3BCN A;  3BBA A;  3PHU A;  2OP3 A;  4IP3 A;  3TNX A;  5FPW A;  4YYW A;  3BPF A;  3K8U A;  1SP4 B;  4OEM A;  3ZUA A;  1A6R A;  4OVZ B;  1QXP A;  2YJC A;  2BU3 A;  2NQA A;  4AXM A;  1PPP A;  3CBK A;  3PDF A;  5JH3 A;  5PAD A; 
#chains in the Genus database with same CATH homology
 4W5C A;  1IWD A;  1PXV A;  4BPV A;  2YJ8 A;  4RY2 A;  3WXE A;  1F2C A;  2ACT A;  1ITO A;  2GFO A;  2PBH A;  2E00 A;  3I06 A;  3LFY A;  3NHE A;  3B79 A;  2DC8 A;  9PAP A;  4BGF A;  1QDQ A;  1CQD A;  3P5V A;  4PAD A;  2E01 A;  4N4Z A;  1FH0 A;  1NB3 A;  1KXR A;  1Y08 A;  4I04 A;  2PRE A;  1YK8 A;  2ATO A;  2DCD A;  1W5R A;  3H6S A;  2G6D A;  2OZ2 A;  2FQ9 A;  3QJ3 A;  1NLJ A;  1VSN A;  4B55 A;  3BPM A;  1TL9 A;  4NV8 A;  4QRG A;  1YAL A;  6PAD A;  3MOR A;  3HHA A;  2JQF R;  3N4C A;  2WBF X;  1AU3 A;  4QBB A;  2CB5 A;  3HWN A;  2Y5B A;  1GMY A;  4YV8 A;  4YYU A;  2H7J A;  5J94 A;  2R9F A;  3KX1 A;  4GUZ A;  1MHW A;  3M99 A;  3ERV A;  2BDL A;  2FRA A;  1CSB B;  2O6X A;  1K3B B;  4QRX A;  1W6F A;  1NQC A;  4XUI A;  1ATK A;  1CB5 A;  2DC6 A;  1BP4 A;  1U9V A;  3V6E A;  1GX3 A;  3QT4 A;  3S3R A;  1GEC E;  2VFC A;  3OF9 A;  1YK7 A;  4ZUX U;  1PAD A;  4MSX A;  1PPN A;  1CV8 A;  1X9Y A;  3MTN A;  1NB5 A;  1QOL A;  4QH6 A;  3PW3 A;  1Q6K A;  2OUL A;  4WA6 A;  3BWK A;  3IHP A;  2DCB A;  3D9W A;  4KLB A;  3H89 A;  1BGO A;  1S4V A;  1U5I A;  4P6E A;  1YT7 A;  2AU1 A;  2R9C A;  2BDZ A;  1VJV A;  1KFX L;  3O0U A;  1GLO A;  1MEG A;  2AS8 A;  3H7D A;  5K16 A;  4N8W A;  3RVX A;  2P86 A;  4DMX A;  4YYR A;  1XKG A;  3KSE A;  2HD5 A;  4W5B A;  1QMY A;  3OIS A;  2AYO A;  4W4U A;  2NQG A;  1PCI A;  1F2B A;  3CBJ A;  1TLO A;  3N3G A;  4HWY A;  3KWB X;  2R6N A;  4CDC B;  2G8E A;  3C9E A;  4PP1 A;  2F7D A;  4DMY A;  1PE6 A;  4OEL A;  1NL6 A;  3QSD A;  1MEM A;  4YVA A;  3P5U A;  2HH5 A;  1AYV A;  3RVW A;  3S3Q A;  3K9M A;  2G7Y A;  2FTD A;  2P0R A;  3U8E A;  2GHU A;  4G54 A;  5CVN B;  2DCC A;  4BSQ A;  1PPD A;  4X6I A;  4X6J A;  2FYE A;  1KHQ A;  1ICF A;  2DCA A;  2DJG B;  2IPP B;  1EWP A;  2Y6E A;  1F29 A;  2AYN A;  4MZS A;  3GCB A;  2AIM A;  1KFU L;  1AU4 A;  5EGW A;  1AU2 A;  1PPO A;  1YVB A;  7PCK A;  2DJF B;  4FJC A;  8PCH A;  4CDD B;  2DC9 A;  2E03 A;  2F1G A;  3AI8 A;  1JQP A;  1EWO A;  4X6H A;  1PIP A;  5CVM A;  1ME3 A;  3LXS A;  2PNS A;  3D6S A;  4Q8G A;  2XU4 A;  2FO5 A;  4Q8H A;  2NQI A;  1POP A;  1AU0 A;  3I3T A;  4XR7 A;  5CVO B;  3KW9 A;  2B1N A;  2DC7 A;  1TU6 A;  3MHS A;  3OF8 A;  3DF0 A;  1EF7 A;  1MDW A;  1U9Q X;  1STF E;  4YYQ A;  1CTE A;  2YJ2 A;  1AEC A;  1HUC B;  1GCB A;  4I07 A;  4CDE B;  1E2T A;  4CZW A;  1CPJ A;  3PBH A;  4YYS A;  5F02 A;  4QRV A;  4PI3 A;  1DEU A;  4K7C A;  3F5V A;  4AXL A;  3WXF A;  1EWL A;  1F2A A;  2IBI A;  3KKU A;  3WXG A;  2XU1 A;  5JA7 A;  5A24 A;  1U9X A;  3IUT A;  2DZZ A;  2JQG R;  3P5X A;  3N3K A;  2HHN A;  1AYW A;  2C0Y A;  4NV7 A;  1BQI A;  3H8C A;  4PP2 E;  3CH2 X;  3USV A;  4FIP A;  4P6G A;  3OVX A;  3H8B A;  1O0E A;  3RVV A;  3IMA A;  3MHH A;  2B1M A;  3PNR A;  1AIM A;  2XU3 A;  2G8J A;  3V6C A;  4BS5 A;  3E1Z B;  1W4T A;  2ARY A;  5CHV A;  1AYU A;  1BY8 A;  2AUX A;  2FT2 A;  1EWM A;  3F75 A;  4CDF B;  2VFB A;  2YJ9 A;  2R9O A;  1Y4H A;  1CVZ A;  4FK5 A;  1ZIV A;  3OVZ A;  2YJB A;  3O1G A;  4MZO A;  2PAD A;  2FRQ A;  1ZCM A;  2AVW A;  2AUZ A;  3KFQ A;  2BSZ A;  1CJL A;  4I05 A;  1M6D A;  2R9M A;  3P5W A;  2DZY A;  3LTW A;  5EF4 A;  3K24 A;  1NPZ A;  3IV2 A;  1KHP A;  1THE A;  3CH3 X;  1U9W A;  2NQD B;  1PBH A;  1CS8 A;  3KWZ A;  4YYV A;  2CIO A;  2HXZ A;  1DF0 A;  2E02 A;  5CHT A;  1SNK A;  3HHI A;  3IEJ A;  2FUD A;  1ME4 A;  4BS6 A;  2P7U A;  1MS6 A;  1MIR A;  3BOW A;  4C5P A;  2XU5 A;  2R9N A;  3HD3 A;  2VHF A;  4N79 A;  3IOQ A;  3BC3 A;  2VHS A;  4BQV A;  3BCN A;  2OP3 A;  3TNX A;  5FPW A;  4YYW A;  3BPF A;  3K8U A;  1SP4 B;  4OEM A;  3ZUA A;  1A6R A;  1QXP A;  2YJC A;  2NQA A;  4AXM A;  1PPP A;  3CBK A;  3PDF A;  5JH3 A;  5PAD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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