3HHIA

Crystal structure of cathepsin b from t. brucei in complex with ca074
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
258
structure length
258
Chain Sequence
SILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACGSCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLVSDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCDYTCDDPTIPVVNYRSWTSYALQGEDDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKIANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma brucei
molecule keywords Cathepsin B-like cysteine protease
total genus 74
structure length 258
sequence length 258
chains with identical sequence B
ec nomenclature ec 3.4.22.-:
pdb deposition date 2009-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3hhiA00
3K8UA 2HD5A 2BDLA 4MSXA 2Y5BA 2DC8A 4PP1A 1POPA 1EF7A 2DJGB 2P0RA 3BPMA 1CVZA 2R9MA 2Y6EA 3F75A 1MHWA 1AU3A 2R9FA 2CIOA 1U9XA 1JQPA 2FO5A 1EWOA 4P6EA 3B79A 1GECE 1ZCMA 3KW9A 4YYRA 1QOLA 2PADA 1KHQA 5PADA 6PADA 2YJ8A 3H89A 3HHIA 1MEMA 1TL9A 1VSNA 3AI8A 2P86A 2VHFA 1ITOA 4I07A 3IEJA 4DMYA 3S3RA 4YYUA 1YK8A 3BOWA 2FTDA 1M6DA 3F5VA 1AYUA 5CHVA 8PCHA 4HWYA 4PADA 1U9VA 4PP2E 2DC7A 1SP4B 2ACTA 3DF0A 1CPJA 3ZUAA 1U5IA 1PIPA 3H6SA 4CDFB 2AUXA 2WBFX 2B1MA 5FPWA 1CV8A 4W5BA 3H8BA 2IBIA 2IPPB 1PXVA 1MS6A 3BPFA 1QDQA 1NPZA 2R6NA 4WA6A 3V6CA 4BS5A 3U8EA 3WXGA 3MHHA 3I3TA 3I06A 4FJCA 3MTNA 2AVWA 1YK7A 5K16A 4N8WA 1U9QX 4CDEB 2VHSA 2O6XA 3RVWA 2DZYA 2R9OA 4CDDB 3HHAA 2AS8A 1AIMA 1EWPA 4KLBA 1TU6A 1BQIA 3CBKA 4QRXA 1CQDA 5A24A 3IMAA 1CTEA 1KXRA 2YJCA 2AU1A 3QJ3A 1A6RA 4BSQA 2OZ2A 4Q8GA 3K9MA 1MDWA 2NQGA 1NB5A 1KFUL 4BPVA 1EWLA 1X9YA 3OVZA 2PNSA 3LXSA 4N4ZA 1BP4A 2FUDA 3K24A 2E00A 2HH5A 2DZZA 3MHSA 4QRGA 1SNKA 1F2CA 1DEUA 3CH3X 3O0UA 3BC3A 5F02A 3KX1A 2ATOA 3IV2A 4ZUXU 9PAPA 5CHTA 3P5UA 4P6GA 2FRAA 2XU1A 2G6DA 1Q6KA 4G54A 1PBHA 2CB5A 1NL6A 3TNXA 3RVXA 4X6IA 1PCIA 2G7YA 2HXZA 5JA7A 2YJ9A 2XU3A 3NHEA 2R9CA 3M99A 1FH0A 2B1NA 1O0EA 2FT2A 3N3GA 4FK5A 1ATKA 1NQCA 2JQGR 1YT7A 1KHPA 2AYNA 2E01A 2BDZA 3GCBA 3H7DA 4CZWA 3WXFA 2H7JA 3P5VA 1MEGA 4N79A 4QH6A 1F2AA 2DC6A 1ICFA 2PREA 1AECA 3CH2X 5EF4A 4YYWA 1K3BB 3MORA 4QBBA 2FRQA 3N3KA 1F2BA 1CSBB 1BGOA 3PW3A 4X6JA 3KKUA 4OEMA 1NB3A 1BY8A 1QXPA 5J94A 5CVOB 4AXMA 1ME4A 2G8EA 4BQVA 2ARYA 3S3QA 1ZIVA 3P5XA 1ME3A 2DCBA 1GCBA 3BWKA 2DC9A 1PPDA 1PPOA 3QSDA 3USVA 3OF8A 2E02A 2DJFB 7PCKA 2DCAA 3IUTA 2NQAA 2OP3A 5JH3A 3PDFA 2G8JA 2GFOA 2PBHA 3KWBX 4W5CA 3H8CA 1MIRA 1STFE 4CDCB 3KFQA 4OELA 3E1ZB 1PADA 5EGWA 4MZSA 4YV8A 3IOQA 1NLJA 2AUZA 1KFXL 3RVVA 2P7UA 4AXLA 3PNRA 1AYVA 1EWMA 1PPPA 3D6SA 1YALA 1AU4A 3P5WA 2XU4A 2F7DA 1VJVA 1U9WA 1GMYA 3QT4A 3OVXA 1F29A 4Q8HA 3C9EA 3PBHA 2GHUA 3CBJA 3LFYA 1IWDA 4MZOA 4I04A 4BS6A 4YVAA 2NQDB 2DCDA 4W4UA 5CVNB 4XUIA 4PI3A 1AU0A 3O1GA 3KSEA 3OISA 5CVMA 2DCCA 2AIMA 1PE6A 2F1GA 2AYOA 2HHNA 3IHPA 4RY2A 3OF9A 3WXEA 1QMYA 2E03A 3V6EA 2YJBA 2JQFR 1CS8A 3KWZA 1XKGA 2OULA 1DF0A 4QRVA 1TLOA 3HWNA 4YYVA 2C0YA 1THEA 4XR7A 1AYWA 3BCNA 1YVBA 1Y4HA 4DMXA 1HUCB 3N4CA 1CB5A 4X6HA 1AU2A 2R9NA 2XU5A 1CJLA 4I05A 1Y08A 4K7CA 1S4VA 4YYQA 4FIPA 3HD3A 1GLOA 1PPNA 2NQIA 2FQ9A 2FYEA 3ERVA 4YYSA 2YJ2A
chains in the Genus database with same CATH superfamily
3K8UA 2HD5A 2BDLA 5KO3A 4MM3B 4MSXA 2Y5BA 2DC8A 4PP1A 1POPA 1EF7A 2DJGB 4BOUA 2P0RA 3PSEA 2DOSA 3BPMA 1CVZA 4R3DA 2R9MA 2Y6EA 3F75A 1MHWA 1AU3A 2R9FA 2CIOA 2JTCA 1U9XA 1JQPA 2FO5A 1EWOA 4P6EA 3B79A 1GECE 1ZCMA 3KW9A 4YYRA 1QOLA 2PADA 1KHQA 5PADA 6PADA 2YJ8A 3H89A 3HHIA 1MEMA 1TL9A 3RNVA 1VSNA 3AI8A 2P86A 3W31A 2BTWB 1ITOA 2VHFA 4I07A 4OW0A 3IEJA 4DMYA 3S3RA 4YYUA 1YK8A 3BOWA 3PHUA 2FTDA 1M6DA 3F5VA 1AYUA 4GUAA 5CHVA 4XZXA 4BOZA 8PCHA 4HWYA 4PADA 3PT2A 1U9VA 4PP2E 2DC7A 1SP4B 2ACTA 3DF0A 1CPJA 3ZUAA 5E6JA 1U5IA 1PIPA 3H6SA 4CDFB 2AUXA 2WBFX 2B1MA 5FPWA 1CV8A 4W5BA 2JRIA 3H8BA 2IBIA 2IPPB 1PXVA 3BBAA 1MS6A 3BPFA 1QDQA 1NPZA 2R6NA 4WA6A 3V6CA 3MTVA 4D8EA 4BS5A 3U8EA 3WXGA 3MHHA 3I3TA 3I06A 4FJCA 3MTNA 2AVWA 1YK7A 5K16A 4N8WA 1U9QX 4CDEB 4M0WA 2VHSA 2O6XA 3RVWA 2DZYA 2R9OA 4BOSA 4CDDB 4PT5A 3HHAA 2AS8A 1AIMA 1EWPA 4KLBA 3TMPA 1TU6A 1BQIA 3C0RA 3CBKA 4QRXA 1CQDA 5A24A 3IMAA 1CTEA 1KXRA 2YJCA 2AU1A 2BU3A 3QJ3A 1A6RA 4BSQA 3BY4A 2OZ2A 4Q8GA 3K9MA 1MDWA 2NQGA 4A5UA 1KFUL 1NB5A 4BPVA 3TRKA 1EWLA 3MP2A 1X9YA 3OVZA 5EZQA 2FE8A 2PNSA 3LXSA 4P16A 1PVJA 4N4ZA 1BP4A 2FUDA 3K24A 2E00A 2HH5A 2DZZA 3MHSA 4QRGA 1SNKA 1F2CA 1DEUA 3CH3X 3O0UA 3BC3A 5F02A 3KX1A 2ATOA 3IV2A 4ZUXU 9PAPA 5CHTA 3P5UA 4P6GA 2FRAA 4BOQA 2XU1A 2G6DA 1Q6KA 4G54A 1PBHA 2CB5A 1NL6A 3PRPA 4RKXA 3TNXA 3RVXA 4X6IA 1PCIA 2G7YA 1UKFA 2HXZA 5JA7A 2YJ9A 2XU3A 4WURA 3NHEA 2R9CA 3M99A 1FH0A 2B1NA 1O0EA 2FT2A 3N3GA 4FK5A 1ATKA 1NQCA 2JQGR 3ZNHA 1YT7A 1KHPA 2AYNA 2E01A 2BDZA 3GCBA 3H7DA 4CZWA 3WXFA 2H7JA 3PHXA 3B21A 3P5VA 1MEGA 4N79A 4QH6A 1F2AA 3BB7A 5JZEA 2DC6A 2HWKA 1ICFA 2PREA 1AECA 3CH2X 5EF4A 4YYWA 1K3BB 3MORA 4QBBA 2FRQA 3N3KA 1F2BA 1CSBB 1BGOA 2Z84A 3PW3A 3KKUA 2J7QC 4X6JA 4OEMA 1NB3A 4OVZA 4HXDB 1BY8A 1QXPA 5J94A 5CVOB 4AXMA 1ME4A 2G8EA 4BQVA 2ARYA 3S3QA 1ZIVA 3P5XA 1ME3A 2DCBA 1GCBA 3BWKA 2DC9A 1PPDA 1PPOA 3QSDA 3USVA 3W30A 3OF8A 2E02A 2DJFB 7PCKA 2DCAA 5EZSA 3IUTA 2NQAA 2OP3A 5JH3A 3PDFA 2G8JA 2GFOA 2PBHA 3KWBX 2UZJA 3H8CA 4W5CA 4D8IA 1MIRA 1STFE 4CDCB 3KFQA 4IUMA 4OELA 3E1ZB 1PADA 5EGWA 4MZSA 4BOPA 4YV8A 3IOQA 4MI7A 1DKIA 1NLJA 2AUZA 1KFXL 3MJ5A 2J7QA 3RVVA 2P7UA 4AXLA 3PNRA 1AYVA 1EWMA 4OVZB 1PPPA 3D6SA 1YALA 3O65A 1AU4A 3P5WA 1YZBA 2XU4A 2F7DA 2AGAA 1VJVA 1U9WA 1GMYA 3QT4A 3OVXA 1F29A 4Q8HA 3C9EA 3PBHA 2GHUA 3CBJA 3LFYA 1IWDA 4MZOA 4I04A 4BS6A 3PRMA 4YVAA 2NQDB 3PHWA 2DCDA 4W4UA 5CVNB 4XUIA 4PI3A 3E9SA 1AU0A 3O1GA 3KSEA 3OISA 5CVMA 2DCCA 4D8BA 2AIMA 1PE6A 3IFUA 2F1GA 2AYOA 2HHNA 3IHPA 4RY2A 3OF9A 3WXEA 1QMYA 2E03A 3V6EA 2YJBA 2JQFR 1CS8A 3KWZA 1XKGA 2OULA 1DF0A 4QRVA 4ZTBA 1TLOA 3HWNA 4YYVA 2C0YA 1THEA 4XR7A 4REZA 1AYWA 3BCNA 1YVBA 1Y4HA 4IP3A 4DMXA 1HUCB 3N4CA 1CB5A 4X6HA 1AU2A 2R9NA 2XU5A 1CJLA 2BTWA 4I05A 1Y08A 4K7CA 1S4VA 4YYQA 4FIPA 3HD3A 1GLOA 4RNAA 1PPNA 2NQIA 2FQ9A 2FYEA 3ERVA 3OQCA 4RF0A 4YYSA 4RF1A 2YJ2A
chains in the Genus database with same CATH topology
3K8UA 2HD5A 2BDLA 4MSXA 2Y5BA 2DC8A 4PP1A 1POPA 1EF7A 2DJGB 2P0RA 3BPMA 1CVZA 2R9MA 2Y6EA 3F75A 1MHWA 1AU3A 2R9FA 2CIOA 1U9XA 1JQPA 2FO5A 4GUZA 1EWOA 4P6EA 2VFBA 1GECE 3B79A 1ZCMA 3KW9A 4YYRA 1QOLA 2PADA 1KHQA 5PADA 6PADA 2YJ8A 3H89A 3HHIA 1MEMA 1TL9A 1VSNA 3AI8A 2P86A 2VHFA 1ITOA 4I07A 3IEJA 4DMYA 3S3RA 4YYUA 1YK8A 3BOWA 2FTDA 1M6DA 3F5VA 1AYUA 5CHVA 8PCHA 4HWYA 4PADA 1U9VA 4PP2E 2DC7A 1SP4B 2ACTA 3DF0A 1CPJA 3ZUAA 1U5IA 1PIPA 3H6SA 4CDFB 2AUXA 2WBFX 2B1MA 5FPWA 1CV8A 4W5BA 3H8BA 2IBIA 2IPPB 1PXVA 1MS6A 3BPFA 1QDQA 1NPZA 2R6NA 4WA6A 3V6CA 4BS5A 3U8EA 3WXGA 3MHHA 3I3TA 3I06A 4FJCA 3MTNA 2AVWA 1YK7A 5K16A 4N8WA 1U9QX 4CDEB 2VHSA 2O6XA 3RVWA 2DZYA 1E2TA 2R9OA 4CDDB 3HHAA 2AS8A 1AIMA 1EWPA 4KLBA 1TU6A 1BQIA 3CBKA 4QRXA 1CQDA 5A24A 3IMAA 1CTEA 1KXRA 2YJCA 2AU1A 3QJ3A 1A6RA 4BSQA 3LTWA 2OZ2A 4Q8GA 3K9MA 1MDWA 2NQGA 1NB5A 1KFUL 4BPVA 1EWLA 1X9YA 3OVZA 2PNSA 3LXSA 4N4ZA 1BP4A 2FUDA 3K24A 2E00A 2HH5A 2DZZA 1GX3A 3MHSA 4BGFA 4QRGA 2BSZA 1SNKA 1F2CA 1DEUA 3CH3X 3O0UA 3BC3A 5F02A 3KX1A 2ATOA 3IV2A 4ZUXU 9PAPA 5CHTA 3P5UA 4P6GA 2FRAA 2XU1A 2G6DA 1Q6KA 4G54A 1PBHA 2CB5A 1NL6A 3TNXA 3RVXA 4X6IA 1PCIA 2G7YA 2HXZA 5JA7A 2YJ9A 2XU3A 4B55A 3NHEA 2R9CA 3M99A 1FH0A 2B1NA 1O0EA 2FT2A 3N3GA 4FK5A 1ATKA 1NQCA 2JQGR 1YT7A 1KHPA 2AYNA 2E01A 2BDZA 3GCBA 3H7DA 4CZWA 3WXFA 4C5PA 2H7JA 3P5VA 1MEGA 4N79A 4QH6A 2VFCA 1F2AA 2DC6A 1ICFA 2PREA 1AECA 3CH2X 5EF4A 4YYWA 1K3BB 3MORA 4QBBA 2FRQA 3N3KA 1F2BA 1W4TA 1CSBB 1BGOA 3PW3A 4X6JA 3KKUA 4OEMA 1NB3A 1BY8A 1QXPA 5J94A 5CVOB 4AXMA 1ME4A 2G8EA 4BQVA 2ARYA 3S3QA 1ZIVA 3P5XA 1ME3A 2DCBA 1GCBA 3BWKA 2DC9A 1PPDA 1PPOA 3QSDA 3USVA 3OF8A 2E02A 2DJFB 7PCKA 2DCAA 3IUTA 2NQAA 2OP3A 5JH3A 3PDFA 2G8JA 2GFOA 2PBHA 3KWBX 4W5CA 3H8CA 1MIRA 1W6FA 1STFE 4CDCB 3KFQA 4OELA 3E1ZB 1PADA 5EGWA 4MZSA 4YV8A 3IOQA 1NLJA 2AUZA 1KFXL 3RVVA 4NV8A 2P7UA 4AXLA 3PNRA 1AYVA 1EWMA 1PPPA 3D6SA 1YALA 1AU4A 3P5WA 2XU4A 2F7DA 1VJVA 1U9WA 1GMYA 3QT4A 3OVXA 1F29A 4Q8HA 3C9EA 3PBHA 1W5RA 3D9WA 2GHUA 3CBJA 3LFYA 1IWDA 4MZOA 4I04A 4BS6A 4YVAA 2NQDB 2DCDA 4W4UA 5CVNB 4XUIA 4PI3A 1AU0A 3O1GA 3KSEA 3OISA 5CVMA 2DCCA 2AIMA 1PE6A 2F1GA 2AYOA 2HHNA 3IHPA 4RY2A 3OF9A 3WXEA 1QMYA 2E03A 3V6EA 2YJBA 2JQFR 1CS8A 3KWZA 1XKGA 2OULA 1DF0A 4QRVA 1TLOA 3HWNA 4YYVA 2C0YA 1THEA 4XR7A 1AYWA 3BCNA 1YVBA 1Y4HA 4DMXA 1HUCB 3N4CA 1CB5A 4X6HA 1AU2A 2R9NA 4NV7A 2XU5A 1CJLA 4I05A 1Y08A 4K7CA 1S4VA 4YYQA 4FIPA 3HD3A 1GLOA 1PPNA 2NQIA 2FQ9A 2FYEA 3ERVA 4YYSA 2YJ2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K8U A;  2HD5 A;  2BDL A;  4MSX A;  2Y5B A;  2DC8 A;  4PP1 A;  1POP A;  1EF7 A;  2DJG B;  2P0R A;  3BPM A;  1CVZ A;  2R9M A;  2Y6E A;  3F75 A;  1MHW A;  1AU3 A;  2R9F A;  2CIO A;  1U9X A;  1JQP A;  2FO5 A;  1EWO A;  4P6E A;  3B79 A;  1GEC E;  1ZCM A;  3KW9 A;  4YYR A;  1QOL A;  2PAD A;  1KHQ A;  5PAD A;  6PAD A;  2YJ8 A;  3H89 A;  3HHI A;  1MEM A;  1TL9 A;  1VSN A;  3AI8 A;  2P86 A;  2VHF A;  1ITO A;  4I07 A;  3IEJ A;  4DMY A;  3S3R A;  4YYU A;  1YK8 A;  3BOW A;  2FTD A;  1M6D A;  3F5V A;  1AYU A;  5CHV A;  8PCH A;  4HWY A;  4PAD A;  1U9V A;  4PP2 E;  2DC7 A;  1SP4 B;  2ACT A;  3DF0 A;  1CPJ A;  3ZUA A;  1U5I A;  1PIP A;  3H6S A;  4CDF B;  2AUX A;  2WBF X;  2B1M A;  5FPW A;  1CV8 A;  4W5B A;  3H8B A;  2IBI A;  2IPP B;  1PXV A;  1MS6 A;  3BPF A;  1QDQ A;  1NPZ A;  2R6N A;  4WA6 A;  3V6C A;  4BS5 A;  3U8E A;  3WXG A;  3MHH A;  3I3T A;  3I06 A;  4FJC A;  3MTN A;  2AVW A;  1YK7 A;  5K16 A;  4N8W A;  1U9Q X;  4CDE B;  2VHS A;  2O6X A;  3RVW A;  2DZY A;  2R9O A;  4CDD B;  3HHA A;  2AS8 A;  1AIM A;  1EWP A;  4KLB A;  1TU6 A;  1BQI A;  3CBK A;  4QRX A;  1CQD A;  5A24 A;  3IMA A;  1CTE A;  1KXR A;  2YJC A;  2AU1 A;  3QJ3 A;  1A6R A;  4BSQ A;  2OZ2 A;  4Q8G A;  3K9M A;  1MDW A;  2NQG A;  1NB5 A;  1KFU L;  4BPV A;  1EWL A;  1X9Y A;  3OVZ A;  2PNS A;  3LXS A;  4N4Z A;  1BP4 A;  2FUD A;  3K24 A;  2E00 A;  2HH5 A;  2DZZ A;  3MHS A;  4QRG A;  1SNK A;  1F2C A;  1DEU A;  3CH3 X;  3O0U A;  3BC3 A;  5F02 A;  3KX1 A;  2ATO A;  3IV2 A;  4ZUX U;  9PAP A;  5CHT A;  3P5U A;  4P6G A;  2FRA A;  2XU1 A;  2G6D A;  1Q6K A;  4G54 A;  1PBH A;  2CB5 A;  1NL6 A;  3TNX A;  3RVX A;  4X6I A;  1PCI A;  2G7Y A;  2HXZ A;  5JA7 A;  2YJ9 A;  2XU3 A;  3NHE A;  2R9C A;  3M99 A;  1FH0 A;  2B1N A;  1O0E A;  2FT2 A;  3N3G A;  4FK5 A;  1ATK A;  1NQC A;  2JQG R;  1YT7 A;  1KHP A;  2AYN A;  2E01 A;  2BDZ A;  3GCB A;  3H7D A;  4CZW A;  3WXF A;  2H7J A;  3P5V A;  1MEG A;  4N79 A;  4QH6 A;  1F2A A;  2DC6 A;  1ICF A;  2PRE A;  1AEC A;  3CH2 X;  5EF4 A;  4YYW A;  1K3B B;  3MOR A;  4QBB A;  2FRQ A;  3N3K A;  1F2B A;  1CSB B;  1BGO A;  3PW3 A;  4X6J A;  3KKU A;  4OEM A;  1NB3 A;  1BY8 A;  1QXP A;  5J94 A;  5CVO B;  4AXM A;  1ME4 A;  2G8E A;  4BQV A;  2ARY A;  3S3Q A;  1ZIV A;  3P5X A;  1ME3 A;  2DCB A;  1GCB A;  3BWK A;  2DC9 A;  1PPD A;  1PPO A;  3QSD A;  3USV A;  3OF8 A;  2E02 A;  2DJF B;  7PCK A;  2DCA A;  3IUT A;  2NQA A;  2OP3 A;  5JH3 A;  3PDF A;  2G8J A;  2GFO A;  2PBH A;  3KWB X;  4W5C A;  3H8C A;  1MIR A;  1STF E;  4CDC B;  3KFQ A;  4OEL A;  3E1Z B;  1PAD A;  5EGW A;  4MZS A;  4YV8 A;  3IOQ A;  1NLJ A;  2AUZ A;  1KFX L;  3RVV A;  2P7U A;  4AXL A;  3PNR A;  1AYV A;  1EWM A;  1PPP A;  3D6S A;  1YAL A;  1AU4 A;  3P5W A;  2XU4 A;  2F7D A;  1VJV A;  1U9W A;  1GMY A;  3QT4 A;  3OVX A;  1F29 A;  4Q8H A;  3C9E A;  3PBH A;  2GHU A;  3CBJ A;  3LFY A;  1IWD A;  4MZO A;  4I04 A;  4BS6 A;  4YVA A;  2NQD B;  2DCD A;  4W4U A;  5CVN B;  4XUI A;  4PI3 A;  1AU0 A;  3O1G A;  3KSE A;  3OIS A;  5CVM A;  2DCC A;  2AIM A;  1PE6 A;  2F1G A;  2AYO A;  2HHN A;  3IHP A;  4RY2 A;  3OF9 A;  3WXE A;  1QMY A;  2E03 A;  3V6E A;  2YJB A;  2JQF R;  1CS8 A;  3KWZ A;  1XKG A;  2OUL A;  1DF0 A;  4QRV A;  1TLO A;  3HWN A;  4YYV A;  2C0Y A;  1THE A;  4XR7 A;  1AYW A;  3BCN A;  1YVB A;  1Y4H A;  4DMX A;  1HUC B;  3N4C A;  1CB5 A;  4X6H A;  1AU2 A;  2R9N A;  2XU5 A;  1CJL A;  4I05 A;  1Y08 A;  4K7C A;  1S4V A;  4YYQ A;  4FIP A;  3HD3 A;  1GLO A;  1PPN A;  2NQI A;  2FQ9 A;  2FYE A;  3ERV A;  4YYS A;  2YJ2 A; 
#chains in the Genus database with same CATH topology
 3K8U A;  2HD5 A;  2BDL A;  5KO3 A;  4MM3 B;  4MSX A;  2Y5B A;  2DC8 A;  4PP1 A;  1POP A;  1EF7 A;  2DJG B;  4BOU A;  2P0R A;  3PSE A;  2DOS A;  3BPM A;  1CVZ A;  4R3D A;  2R9M A;  2Y6E A;  3F75 A;  1MHW A;  1AU3 A;  2R9F A;  2CIO A;  2JTC A;  1U9X A;  1JQP A;  2FO5 A;  1EWO A;  4P6E A;  3B79 A;  1GEC E;  1ZCM A;  3KW9 A;  4YYR A;  1QOL A;  2PAD A;  1KHQ A;  5PAD A;  6PAD A;  2YJ8 A;  3H89 A;  3HHI A;  1MEM A;  1TL9 A;  3RNV A;  1VSN A;  3AI8 A;  2P86 A;  3W31 A;  2BTW B;  1ITO A;  2VHF A;  4I07 A;  4OW0 A;  3IEJ A;  4DMY A;  3S3R A;  4YYU A;  1YK8 A;  3BOW A;  3PHU A;  2FTD A;  1M6D A;  3F5V A;  1AYU A;  4GUA A;  5CHV A;  4XZX A;  4BOZ A;  8PCH A;  4HWY A;  4PAD A;  3PT2 A;  1U9V A;  4PP2 E;  2DC7 A;  1SP4 B;  2ACT A;  3DF0 A;  1CPJ A;  3ZUA A;  5E6J A;  1U5I A;  1PIP A;  3H6S A;  4CDF B;  2AUX A;  2WBF X;  2B1M A;  5FPW A;  1CV8 A;  4W5B A;  2JRI A;  3H8B A;  2IBI A;  2IPP B;  1PXV A;  3BBA A;  1MS6 A;  3BPF A;  1QDQ A;  1NPZ A;  2R6N A;  4WA6 A;  3V6C A;  3MTV A;  4D8E A;  4BS5 A;  3U8E A;  3WXG A;  3MHH A;  3I3T A;  3I06 A;  4FJC A;  3MTN A;  2AVW A;  1YK7 A;  5K16 A;  4N8W A;  1U9Q X;  4CDE B;  4M0W A;  2VHS A;  2O6X A;  3RVW A;  2DZY A;  2R9O A;  4BOS A;  4CDD B;  4PT5 A;  3HHA A;  2AS8 A;  1AIM A;  1EWP A;  4KLB A;  3TMP A;  1TU6 A;  1BQI A;  3C0R A;  3CBK A;  4QRX A;  1CQD A;  5A24 A;  3IMA A;  1CTE A;  1KXR A;  2YJC A;  2AU1 A;  2BU3 A;  3QJ3 A;  1A6R A;  4BSQ A;  3BY4 A;  2OZ2 A;  4Q8G A;  3K9M A;  1MDW A;  2NQG A;  4A5U A;  1KFU L;  1NB5 A;  4BPV A;  3TRK A;  1EWL A;  3MP2 A;  1X9Y A;  3OVZ A;  5EZQ A;  2FE8 A;  2PNS A;  3LXS A;  4P16 A;  1PVJ A;  4N4Z A;  1BP4 A;  2FUD A;  3K24 A;  2E00 A;  2HH5 A;  2DZZ A;  3MHS A;  4QRG A;  1SNK A;  1F2C A;  1DEU A;  3CH3 X;  3O0U A;  3BC3 A;  5F02 A;  3KX1 A;  2ATO A;  3IV2 A;  4ZUX U;  9PAP A;  5CHT A;  3P5U A;  4P6G A;  2FRA A;  4BOQ A;  2XU1 A;  2G6D A;  1Q6K A;  4G54 A;  1PBH A;  2CB5 A;  1NL6 A;  3PRP A;  4RKX A;  3TNX A;  3RVX A;  4X6I A;  1PCI A;  2G7Y A;  1UKF A;  2HXZ A;  5JA7 A;  2YJ9 A;  2XU3 A;  4WUR A;  3NHE A;  2R9C A;  3M99 A;  1FH0 A;  2B1N A;  1O0E A;  2FT2 A;  3N3G A;  4FK5 A;  1ATK A;  1NQC A;  2JQG R;  3ZNH A;  1YT7 A;  1KHP A;  2AYN A;  2E01 A;  2BDZ A;  3GCB A;  3H7D A;  4CZW A;  3WXF A;  2H7J A;  3PHX A;  3B21 A;  3P5V A;  1MEG A;  4N79 A;  4QH6 A;  1F2A A;  3BB7 A;  5JZE A;  2DC6 A;  2HWK A;  1ICF A;  2PRE A;  1AEC A;  3CH2 X;  5EF4 A;  4YYW A;  1K3B B;  3MOR A;  4QBB A;  2FRQ A;  3N3K A;  1F2B A;  1CSB B;  1BGO A;  2Z84 A;  3PW3 A;  3KKU A;  2J7Q C;  4X6J A;  4OEM A;  1NB3 A;  4OVZ A;  4HXD B;  1BY8 A;  1QXP A;  5J94 A;  5CVO B;  4AXM A;  1ME4 A;  2G8E A;  4BQV A;  2ARY A;  3S3Q A;  1ZIV A;  3P5X A;  1ME3 A;  2DCB A;  1GCB A;  3BWK A;  2DC9 A;  1PPD A;  1PPO A;  3QSD A;  3USV A;  3W30 A;  3OF8 A;  2E02 A;  2DJF B;  7PCK A;  2DCA A;  5EZS A;  3IUT A;  2NQA A;  2OP3 A;  5JH3 A;  3PDF A;  2G8J A;  2GFO A;  2PBH A;  3KWB X;  2UZJ A;  3H8C A;  4W5C A;  4D8I A;  1MIR A;  1STF E;  4CDC B;  3KFQ A;  4IUM A;  4OEL A;  3E1Z B;  1PAD A;  5EGW A;  4MZS A;  4BOP A;  4YV8 A;  3IOQ A;  4MI7 A;  1DKI A;  1NLJ A;  2AUZ A;  1KFX L;  3MJ5 A;  2J7Q A;  3RVV A;  2P7U A;  4AXL A;  3PNR A;  1AYV A;  1EWM A;  4OVZ B;  1PPP A;  3D6S A;  1YAL A;  3O65 A;  1AU4 A;  3P5W A;  1YZB A;  2XU4 A;  2F7D A;  2AGA A;  1VJV A;  1U9W A;  1GMY A;  3QT4 A;  3OVX A;  1F29 A;  4Q8H A;  3C9E A;  3PBH A;  2GHU A;  3CBJ A;  3LFY A;  1IWD A;  4MZO A;  4I04 A;  4BS6 A;  3PRM A;  4YVA A;  2NQD B;  3PHW A;  2DCD A;  4W4U A;  5CVN B;  4XUI A;  4PI3 A;  3E9S A;  1AU0 A;  3O1G A;  3KSE A;  3OIS A;  5CVM A;  2DCC A;  4D8B A;  2AIM A;  1PE6 A;  3IFU A;  2F1G A;  2AYO A;  2HHN A;  3IHP A;  4RY2 A;  3OF9 A;  3WXE A;  1QMY A;  2E03 A;  3V6E A;  2YJB A;  2JQF R;  1CS8 A;  3KWZ A;  1XKG A;  2OUL A;  1DF0 A;  4QRV A;  4ZTB A;  1TLO A;  3HWN A;  4YYV A;  2C0Y A;  1THE A;  4XR7 A;  4REZ A;  1AYW A;  3BCN A;  1YVB A;  1Y4H A;  4IP3 A;  4DMX A;  1HUC B;  3N4C A;  1CB5 A;  4X6H A;  1AU2 A;  2R9N A;  2XU5 A;  1CJL A;  2BTW A;  4I05 A;  1Y08 A;  4K7C A;  1S4V A;  4YYQ A;  4FIP A;  3HD3 A;  1GLO A;  4RNA A;  1PPN A;  2NQI A;  2FQ9 A;  2FYE A;  3ERV A;  3OQC A;  4RF0 A;  4YYS A;  4RF1 A;  2YJ2 A; 
#chains in the Genus database with same CATH homology
 3K8U A;  2HD5 A;  2BDL A;  4MSX A;  2Y5B A;  2DC8 A;  4PP1 A;  1POP A;  1EF7 A;  2DJG B;  2P0R A;  3BPM A;  1CVZ A;  2R9M A;  2Y6E A;  3F75 A;  1MHW A;  1AU3 A;  2R9F A;  2CIO A;  1U9X A;  1JQP A;  2FO5 A;  4GUZ A;  1EWO A;  4P6E A;  2VFB A;  1GEC E;  3B79 A;  1ZCM A;  3KW9 A;  4YYR A;  1QOL A;  2PAD A;  1KHQ A;  5PAD A;  6PAD A;  2YJ8 A;  3H89 A;  3HHI A;  1MEM A;  1TL9 A;  1VSN A;  3AI8 A;  2P86 A;  2VHF A;  1ITO A;  4I07 A;  3IEJ A;  4DMY A;  3S3R A;  4YYU A;  1YK8 A;  3BOW A;  2FTD A;  1M6D A;  3F5V A;  1AYU A;  5CHV A;  8PCH A;  4HWY A;  4PAD A;  1U9V A;  4PP2 E;  2DC7 A;  1SP4 B;  2ACT A;  3DF0 A;  1CPJ A;  3ZUA A;  1U5I A;  1PIP A;  3H6S A;  4CDF B;  2AUX A;  2WBF X;  2B1M A;  5FPW A;  1CV8 A;  4W5B A;  3H8B A;  2IBI A;  2IPP B;  1PXV A;  1MS6 A;  3BPF A;  1QDQ A;  1NPZ A;  2R6N A;  4WA6 A;  3V6C A;  4BS5 A;  3U8E A;  3WXG A;  3MHH A;  3I3T A;  3I06 A;  4FJC A;  3MTN A;  2AVW A;  1YK7 A;  5K16 A;  4N8W A;  1U9Q X;  4CDE B;  2VHS A;  2O6X A;  3RVW A;  2DZY A;  1E2T A;  2R9O A;  4CDD B;  3HHA A;  2AS8 A;  1AIM A;  1EWP A;  4KLB A;  1TU6 A;  1BQI A;  3CBK A;  4QRX A;  1CQD A;  5A24 A;  3IMA A;  1CTE A;  1KXR A;  2YJC A;  2AU1 A;  3QJ3 A;  1A6R A;  4BSQ A;  3LTW A;  2OZ2 A;  4Q8G A;  3K9M A;  1MDW A;  2NQG A;  1NB5 A;  1KFU L;  4BPV A;  1EWL A;  1X9Y A;  3OVZ A;  2PNS A;  3LXS A;  4N4Z A;  1BP4 A;  2FUD A;  3K24 A;  2E00 A;  2HH5 A;  2DZZ A;  1GX3 A;  3MHS A;  4BGF A;  4QRG A;  2BSZ A;  1SNK A;  1F2C A;  1DEU A;  3CH3 X;  3O0U A;  3BC3 A;  5F02 A;  3KX1 A;  2ATO A;  3IV2 A;  4ZUX U;  9PAP A;  5CHT A;  3P5U A;  4P6G A;  2FRA A;  2XU1 A;  2G6D A;  1Q6K A;  4G54 A;  1PBH A;  2CB5 A;  1NL6 A;  3TNX A;  3RVX A;  4X6I A;  1PCI A;  2G7Y A;  2HXZ A;  5JA7 A;  2YJ9 A;  2XU3 A;  4B55 A;  3NHE A;  2R9C A;  3M99 A;  1FH0 A;  2B1N A;  1O0E A;  2FT2 A;  3N3G A;  4FK5 A;  1ATK A;  1NQC A;  2JQG R;  1YT7 A;  1KHP A;  2AYN A;  2E01 A;  2BDZ A;  3GCB A;  3H7D A;  4CZW A;  3WXF A;  4C5P A;  2H7J A;  3P5V A;  1MEG A;  4N79 A;  4QH6 A;  2VFC A;  1F2A A;  2DC6 A;  1ICF A;  2PRE A;  1AEC A;  3CH2 X;  5EF4 A;  4YYW A;  1K3B B;  3MOR A;  4QBB A;  2FRQ A;  3N3K A;  1F2B A;  1W4T A;  1CSB B;  1BGO A;  3PW3 A;  4X6J A;  3KKU A;  4OEM A;  1NB3 A;  1BY8 A;  1QXP A;  5J94 A;  5CVO B;  4AXM A;  1ME4 A;  2G8E A;  4BQV A;  2ARY A;  3S3Q A;  1ZIV A;  3P5X A;  1ME3 A;  2DCB A;  1GCB A;  3BWK A;  2DC9 A;  1PPD A;  1PPO A;  3QSD A;  3USV A;  3OF8 A;  2E02 A;  2DJF B;  7PCK A;  2DCA A;  3IUT A;  2NQA A;  2OP3 A;  5JH3 A;  3PDF A;  2G8J A;  2GFO A;  2PBH A;  3KWB X;  4W5C A;  3H8C A;  1MIR A;  1W6F A;  1STF E;  4CDC B;  3KFQ A;  4OEL A;  3E1Z B;  1PAD A;  5EGW A;  4MZS A;  4YV8 A;  3IOQ A;  1NLJ A;  2AUZ A;  1KFX L;  3RVV A;  4NV8 A;  2P7U A;  4AXL A;  3PNR A;  1AYV A;  1EWM A;  1PPP A;  3D6S A;  1YAL A;  1AU4 A;  3P5W A;  2XU4 A;  2F7D A;  1VJV A;  1U9W A;  1GMY A;  3QT4 A;  3OVX A;  1F29 A;  4Q8H A;  3C9E A;  3PBH A;  1W5R A;  3D9W A;  2GHU A;  3CBJ A;  3LFY A;  1IWD A;  4MZO A;  4I04 A;  4BS6 A;  4YVA A;  2NQD B;  2DCD A;  4W4U A;  5CVN B;  4XUI A;  4PI3 A;  1AU0 A;  3O1G A;  3KSE A;  3OIS A;  5CVM A;  2DCC A;  2AIM A;  1PE6 A;  2F1G A;  2AYO A;  2HHN A;  3IHP A;  4RY2 A;  3OF9 A;  3WXE A;  1QMY A;  2E03 A;  3V6E A;  2YJB A;  2JQF R;  1CS8 A;  3KWZ A;  1XKG A;  2OUL A;  1DF0 A;  4QRV A;  1TLO A;  3HWN A;  4YYV A;  2C0Y A;  1THE A;  4XR7 A;  1AYW A;  3BCN A;  1YVB A;  1Y4H A;  4DMX A;  1HUC B;  3N4C A;  1CB5 A;  4X6H A;  1AU2 A;  2R9N A;  4NV7 A;  2XU5 A;  1CJL A;  4I05 A;  1Y08 A;  4K7C A;  1S4V A;  4YYQ A;  4FIP A;  3HD3 A;  1GLO A;  1PPN A;  2NQI A;  2FQ9 A;  2FYE A;  3ERV A;  4YYS A;  2YJ2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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