3IEJA

Pyrazole-based cathepsin s inhibitors with arylalkynes as p1 binding elements
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
221
structure length
221
Chain Sequence
AALPDSVDWREKGCVTEVKYQGSCGASWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEILQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Cathepsin S
total genus 69
structure length 221
sequence length 221
chains with identical sequence B
ec nomenclature ec 3.4.22.27: Cathepsin S.
pdb deposition date 2009-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3iejA00
2OULA 1PXVA 4PI3A 4BS5A 1TL9A 2B1NA 1TLOA 1SP4B 3P5VA 4W5CA 2NQGA 2NQDB 3OF9A 1ITOA 3B79A 3IUTA 3K8UA 2F7DA 2NQIA 1AYUA 2YJCA 3KFQA 1ZIVA 2PBHA 1GLOA 1SNKA 1NLJA 5JH3A 1PCIA 1EWOA 1QMYA 1U9VA 2DCCA 3H7DA 3RVVA 4QRXA 3PBHA 3WXFA 5JA7A 4CDEB 1DF0A 4QRVA 3S3QA 4QBBA 1AYWA 3QT4A 2ACTA 7PCKA 1NB5A 1AIMA 8PCHA 1POPA 2HXZA 2BDZA 1NB3A 1KHPA 5CHTA 4FIPA 4KLBA 5J94A 2FUDA 2DCAA 1CB5A 2JQFR 3MORA 2OZ2A 1YVBA 1PPPA 2FYEA 1VSNA 3PNRA 4YYVA 2DZYA 5EF4A 2VHFA 2PNSA 4YYSA 4PP2E 2R9OA 1AU4A 5CVOB 4P6EA 4FK5A 3RVXA 3PDFA 3KX1A 1MIRA 4MZOA 2AS8A 2O6XA 4CDCB 4AXMA 2DC6A 3H6SA 3KWBX 1BGOA 2DJFB 1BY8A 2G8EA 3HHAA 1MHWA 4YYUA 2IBIA 1KFUL 5CVNB 1CSBB 3DF0A 4BQVA 1QDQA 3NHEA 4BS6A 1NQCA 1O0EA 2JQGR 1PPOA 3OISA 2G6DA 1KFXL 4QRGA 3HD3A 3MHHA 1MEMA 1QXPA 4PADA 1ATKA 1PPDA 2G7YA 2BDLA 3GCBA 3I06A 1KXRA 4PP1A 3LFYA 1K3BB 1PADA 1CQDA 1DEUA 2AIMA 2YJBA 3KW9A 2DZZA 1KHQA 2Y6EA 4MZSA 3S3RA 3KWZA 4N79A 3K9MA 3BPMA 1NPZA 2AVWA 4I07A 3BWKA 3RVWA 4YV8A 5F02A 1CV8A 2C0YA 4ZUXU 2DC7A 2AU1A 4YYQA 2H7JA 1BQIA 3H8BA 3P5XA 1MDWA 1F2AA 1U9WA 4OELA 1CTEA 2PREA 3BOWA 5K16A 5FPWA 4K7CA 3N3GA 3N4CA 2ARYA 4XR7A 2FTDA 2R9CA 5PADA 3WXEA 1YT7A 1EF7A 3OF8A 4MSXA 2VHSA 6PADA 4N4ZA 3BCNA 4Q8GA 3O1GA 3M99A 1MEGA 3ZUAA 3V6EA 2YJ9A 2YJ8A 2E02A 2ATOA 1EWMA 1Y08A 4W5BA 4W4UA 1ME4A 4YVAA 3O0UA 2GFOA 3OVZA 1S4VA 3WXGA 3AI8A 2FRAA 2AYNA 2F1GA 3P5WA 2XU5A 2FT2A 3HHIA 4HWYA 1CJLA 1HUCB 1JQPA 1XKGA 2AUXA 3U8EA 1MS6A 2DCDA 3IHPA 4YYWA 3HWNA 1PE6A 1M6DA 2YJ2A 3F75A 2XU1A 2P7UA 3KSEA 1A6RA 5CHVA 2P0RA 2R9MA 1ME3A 2FO5A 1PBHA 2R9NA 1VJVA 2DJGB 2WBFX 2B1MA 1Q6KA 1AU2A 3CH3X 4QH6A 4BSQA 3BC3A 1YK8A 4X6IA 3USVA 1PPNA 2HD5A 2DCBA 1AECA 3OVXA 4AXLA 2XU4A 1GMYA 5CVMA 2E03A 3N3KA 3CBKA 3P5UA 2HHNA 4DMYA 4I05A 1THEA 3IV2A 2E00A 1AU0A 1ICFA 2FQ9A 4CZWA 4G54A 3IMAA 1FH0A 3C9EA 1AYVA 4BPVA 4CDFB 1F2CA 1YK7A 2R9FA 4P6GA 9PAPA 2HH5A 4XUIA 1U5IA 3QSDA 2GHUA 2E01A 4X6HA 3ERVA 2FRQA 3QJ3A 4DMXA 3V6CA 1U9QX 4YYRA 2Y5BA 3IOQA 4FJCA 1F2BA 2OP3A 4RY2A 4Q8HA 5EGWA 3E1ZB 3TNXA 1X9YA 3MHSA 1ZCMA 3H89A 2R6NA 3PW3A 1YALA 2AUZA 2CB5A 1IWDA 1TU6A 2CIOA 3F5VA 2XU3A 1CPJA 1EWPA 4WA6A 1GECE 3MTNA 2IPPB 4CDDB 3IEJA 2AYOA 1BP4A 4I04A 1CS8A 3LXSA 2PADA 1U9XA 3CH2X 2G8JA 3K24A 3KKUA 2DC8A 1CVZA 2NQAA 3BPFA 1GCBA 1EWLA 1NL6A 1Y4HA 2P86A 1F29A 4X6JA 3CBJA 1STFE 1PIPA 1AU3A 1QOLA 3D6SA 2DC9A 3I3TA 5A24A 3H8CA 4OEMA 4N8WA
chains in the Genus database with same CATH superfamily
2OULA 3TRKA 1PXVA 4PI3A 4BS5A 1TL9A 2B1NA 4ZTBA 5EZQA 1TLOA 1SP4B 3P5VA 4W5CA 2NQGA 2NQDB 3OF9A 1ITOA 3B79A 3IUTA 3K8UA 2JRIA 2F7DA 2NQIA 1AYUA 2YJCA 3KFQA 1ZIVA 2PBHA 1GLOA 1SNKA 4BOUA 1NLJA 5JH3A 1PCIA 2FE8A 1EWOA 1QMYA 1U9VA 2DCCA 5JZEA 3H7DA 3RVVA 4QRXA 3PBHA 4RF1A 3WXFA 5JA7A 4CDEB 4BOQA 1DF0A 4QRVA 3S3QA 4QBBA 1AYWA 3QT4A 2ACTA 4RKXA 7PCKA 1NB5A 1AIMA 8PCHA 1POPA 2HXZA 2BDZA 1NB3A 1KHPA 5CHTA 4FIPA 4KLBA 4D8IA 5J94A 2FUDA 2DCAA 1CB5A 2JQFR 4OVZA 3MORA 2OZ2A 1YVBA 1PPPA 2FYEA 1VSNA 3PNRA 4YYVA 2DZYA 5EF4A 2VHFA 2PNSA 4YYSA 4PP2E 4XZXA 2R9OA 1AU4A 5E6JA 5CVOB 4P6EA 4FK5A 3RVXA 3PDFA 3KX1A 1MIRA 4MZOA 2AS8A 2O6XA 4CDCB 1DKIA 4AXMA 2DC6A 3H6SA 3KWBX 1BGOA 2J7QC 2DJFB 1BY8A 4IP3A 2G8EA 3HHAA 1MHWA 4YYUA 2IBIA 1KFUL 5CVNB 1CSBB 3W31A 3DF0A 4BQVA 1QDQA 4MM3B 3NHEA 4BS6A 1NQCA 1O0EA 2JQGR 1PPOA 4OW0A 3OISA 2G6DA 1KFXL 4QRGA 3HD3A 4RNAA 3C0RA 3MHHA 3TMPA 1MEMA 1QXPA 4PADA 4RF0A 1ATKA 1PPDA 2G7YA 2BDLA 3GCBA 3I06A 1KXRA 4WURA 4MI7A 4PP1A 3LFYA 1K3BB 1PADA 1CQDA 1DEUA 2AIMA 2YJBA 3KW9A 3O65A 2DZZA 1KHQA 2Y6EA 4MZSA 3S3RA 3KWZA 4N79A 3K9MA 3BPMA 1NPZA 2AVWA 4I07A 3BWKA 3RVWA 4YV8A 5F02A 3MTVA 1CV8A 4BOZA 1YZBA 2C0YA 2Z84A 3BY4A 4ZUXU 3ZNHA 2DC7A 2AU1A 4YYQA 2H7JA 1BQIA 3H8BA 4M0WA 3P5XA 1MDWA 1F2AA 1U9WA 4OELA 1CTEA 2PREA 3BOWA 5K16A 5FPWA 4K7CA 3N3GA 3N4CA 2ARYA 4XR7A 2FTDA 2R9CA 5PADA 2J7QA 3WXEA 1YT7A 1EF7A 3OF8A 3B21A 4MSXA 2VHSA 3IFUA 6PADA 4N4ZA 4BOPA 3BCNA 3OQCA 4Q8GA 3O1GA 3M99A 1MEGA 3ZUAA 3V6EA 2YJ9A 2YJ8A 2E02A 2ATOA 1EWMA 1Y08A 4W5BA 4W4UA 1ME4A 4YVAA 3O0UA 2GFOA 3OVZA 1S4VA 3WXGA 3AI8A 2BTWB 3PRPA 2FRAA 1UKFA 2AYNA 2F1GA 3P5WA 2XU5A 2FT2A 3HHIA 4HWYA 1CJLA 1HUCB 1JQPA 1XKGA 2AUXA 3U8EA 1MS6A 3MP2A 2DCDA 3IHPA 4YYWA 3HWNA 1PE6A 4D8EA 1M6DA 2YJ2A 3F75A 2XU1A 2P7UA 3KSEA 1A6RA 5CHVA 2P0RA 2R9MA 1ME3A 2FO5A 1PBHA 2R9NA 2UZJA 1VJVA 2DJGB 2WBFX 2B1MA 1Q6KA 1AU2A 3CH3X 4QH6A 4BSQA 3BC3A 1YK8A 4D8BA 4GUAA 4X6IA 3USVA 1PPNA 2HD5A 2DCBA 2JTCA 1AECA 2AGAA 3OVXA 4AXLA 2XU4A 1GMYA 5CVMA 2E03A 3RNVA 3N3KA 3CBKA 3P5UA 2HHNA 3BB7A 4DMYA 3PHUA 4REZA 4R3DA 4I05A 1THEA 3PT2A 3IV2A 2E00A 2HWKA 1AU0A 1ICFA 2FQ9A 4CZWA 4IUMA 4G54A 3IMAA 2DOSA 1FH0A 3C9EA 1AYVA 4BPVA 4CDFB 3PHWA 1F2CA 1YK7A 2R9FA 4P6GA 1PVJA 9PAPA 2HH5A 4XUIA 1U5IA 3QSDA 3PSEA 2GHUA 2E01A 4X6HA 3ERVA 2FRQA 3QJ3A 4DMXA 2BTWA 3V6CA 1U9QX 4YYRA 3BBAA 2Y5BA 3IOQA 4FJCA 1F2BA 2OP3A 3PRMA 4RY2A 4Q8HA 5EGWA 3E1ZB 3TNXA 1X9YA 3MHSA 4P16A 1ZCMA 3H89A 2R6NA 3PW3A 3E9SA 1YALA 2AUZA 2CB5A 4PT5A 5EZSA 1IWDA 1TU6A 2CIOA 3F5VA 2XU3A 1CPJA 4OVZB 2BU3A 1EWPA 4WA6A 1GECE 3MTNA 2IPPB 4CDDB 3IEJA 2AYOA 1BP4A 4I04A 1CS8A 3LXSA 2PADA 1U9XA 3CH2X 2G8JA 3K24A 3KKUA 3MJ5A 2DC8A 4HXDB 1CVZA 2NQAA 3BPFA 1GCBA 4BOSA 1EWLA 3PHXA 1NL6A 1Y4HA 2P86A 1F29A 4X6JA 4A5UA 3W30A 3CBJA 1STFE 1PIPA 1AU3A 1QOLA 3D6SA 2DC9A 3I3TA 5KO3A 5A24A 3H8CA 4OEMA 4N8WA
chains in the Genus database with same CATH topology
2OULA 1PXVA 4PI3A 4BS5A 1TL9A 2B1NA 1TLOA 1SP4B 3P5VA 4W5CA 2NQGA 2NQDB 3OF9A 1ITOA 3B79A 3IUTA 3K8UA 2F7DA 2NQIA 1AYUA 2YJCA 3KFQA 1ZIVA 2PBHA 1GLOA 1SNKA 1NLJA 5JH3A 1PCIA 1EWOA 1QMYA 1U9VA 2DCCA 3H7DA 3RVVA 4QRXA 3PBHA 3WXFA 5JA7A 4CDEB 1DF0A 4QRVA 3S3QA 4QBBA 1AYWA 3QT4A 2ACTA 7PCKA 1NB5A 1AIMA 8PCHA 1POPA 2HXZA 2BDZA 1NB3A 1KHPA 5CHTA 4FIPA 4KLBA 5J94A 2FUDA 2DCAA 1CB5A 2JQFR 3MORA 2OZ2A 1YVBA 1PPPA 2FYEA 1VSNA 3PNRA 4YYVA 2DZYA 5EF4A 2VHFA 1W5RA 2PNSA 4YYSA 4PP2E 2R9OA 1AU4A 5CVOB 4P6EA 4FK5A 3RVXA 3PDFA 3KX1A 1MIRA 4MZOA 2AS8A 2O6XA 4CDCB 4AXMA 2DC6A 3H6SA 3KWBX 1BGOA 2DJFB 1BY8A 2G8EA 3HHAA 1MHWA 4YYUA 2IBIA 1KFUL 5CVNB 1CSBB 3DF0A 4BQVA 1QDQA 3NHEA 4BS6A 1NQCA 1O0EA 1W6FA 2JQGR 1PPOA 3OISA 2G6DA 1KFXL 4QRGA 3HD3A 3MHHA 1MEMA 1QXPA 4PADA 2VFBA 1ATKA 1PPDA 2G7YA 2BDLA 3GCBA 3I06A 1KXRA 4PP1A 3LFYA 1K3BB 1PADA 1CQDA 1DEUA 2AIMA 2YJBA 3KW9A 2DZZA 1KHQA 2Y6EA 4MZSA 3S3RA 1E2TA 3KWZA 4N79A 3K9MA 3BPMA 1NPZA 2AVWA 4I07A 3BWKA 3RVWA 4YV8A 5F02A 1CV8A 2C0YA 4ZUXU 2DC7A 2AU1A 4YYQA 2H7JA 1BQIA 4NV8A 3H8BA 3P5XA 1MDWA 1F2AA 1U9WA 4OELA 1CTEA 2PREA 3BOWA 5K16A 5FPWA 4K7CA 3N3GA 3N4CA 2ARYA 4XR7A 2FTDA 2R9CA 5PADA 3WXEA 1YT7A 1EF7A 3OF8A 4MSXA 2VHSA 4NV7A 6PADA 3LTWA 4N4ZA 4BGFA 3D9WA 3BCNA 4Q8GA 3O1GA 3M99A 1MEGA 3ZUAA 3V6EA 2YJ9A 2YJ8A 2E02A 2ATOA 1EWMA 1Y08A 4W5BA 4W4UA 1ME4A 4YVAA 3O0UA 2GFOA 2VFCA 3OVZA 1S4VA 3WXGA 3AI8A 2FRAA 2AYNA 2F1GA 3P5WA 2XU5A 2FT2A 3HHIA 4HWYA 1CJLA 1HUCB 1JQPA 1XKGA 2AUXA 3U8EA 1MS6A 2DCDA 3IHPA 4YYWA 3HWNA 1PE6A 1M6DA 2YJ2A 3F75A 2XU1A 2P7UA 3KSEA 1A6RA 5CHVA 2P0RA 2R9MA 1ME3A 2FO5A 1PBHA 2R9NA 1VJVA 2DJGB 2WBFX 2B1MA 1Q6KA 1AU2A 3CH3X 4QH6A 4BSQA 3BC3A 1YK8A 4X6IA 3USVA 1PPNA 2HD5A 2DCBA 1AECA 3OVXA 4AXLA 2XU4A 1GMYA 5CVMA 2E03A 3N3KA 3CBKA 3P5UA 4B55A 2HHNA 4DMYA 4I05A 1THEA 3IV2A 2E00A 1W4TA 1AU0A 1ICFA 2FQ9A 4CZWA 4C5PA 4G54A 4GUZA 3IMAA 1FH0A 3C9EA 1AYVA 4BPVA 4CDFB 1F2CA 1YK7A 2R9FA 4P6GA 9PAPA 2HH5A 4XUIA 1U5IA 3QSDA 2GHUA 2E01A 4X6HA 3ERVA 2FRQA 3QJ3A 4DMXA 3V6CA 1U9QX 4YYRA 2Y5BA 3IOQA 4FJCA 1F2BA 2OP3A 4RY2A 4Q8HA 5EGWA 3E1ZB 3TNXA 1X9YA 3MHSA 1ZCMA 3H89A 2R6NA 3PW3A 1YALA 2AUZA 2CB5A 1IWDA 1TU6A 2CIOA 3F5VA 2XU3A 1CPJA 1GX3A 1EWPA 4WA6A 1GECE 3MTNA 2IPPB 4CDDB 3IEJA 2AYOA 1BP4A 4I04A 1CS8A 2BSZA 3LXSA 2PADA 1U9XA 3CH2X 2G8JA 3K24A 3KKUA 2DC8A 1CVZA 2NQAA 3BPFA 1GCBA 1EWLA 1NL6A 1Y4HA 2P86A 1F29A 4X6JA 3CBJA 1STFE 1PIPA 1AU3A 1QOLA 3D6SA 2DC9A 3I3TA 5A24A 3H8CA 4OEMA 4N8WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OUL A;  1PXV A;  4PI3 A;  4BS5 A;  1TL9 A;  2B1N A;  1TLO A;  1SP4 B;  3P5V A;  4W5C A;  2NQG A;  2NQD B;  3OF9 A;  1ITO A;  3B79 A;  3IUT A;  3K8U A;  2F7D A;  2NQI A;  1AYU A;  2YJC A;  3KFQ A;  1ZIV A;  2PBH A;  1GLO A;  1SNK A;  1NLJ A;  5JH3 A;  1PCI A;  1EWO A;  1QMY A;  1U9V A;  2DCC A;  3H7D A;  3RVV A;  4QRX A;  3PBH A;  3WXF A;  5JA7 A;  4CDE B;  1DF0 A;  4QRV A;  3S3Q A;  4QBB A;  1AYW A;  3QT4 A;  2ACT A;  7PCK A;  1NB5 A;  1AIM A;  8PCH A;  1POP A;  2HXZ A;  2BDZ A;  1NB3 A;  1KHP A;  5CHT A;  4FIP A;  4KLB A;  5J94 A;  2FUD A;  2DCA A;  1CB5 A;  2JQF R;  3MOR A;  2OZ2 A;  1YVB A;  1PPP A;  2FYE A;  1VSN A;  3PNR A;  4YYV A;  2DZY A;  5EF4 A;  2VHF A;  2PNS A;  4YYS A;  4PP2 E;  2R9O A;  1AU4 A;  5CVO B;  4P6E A;  4FK5 A;  3RVX A;  3PDF A;  3KX1 A;  1MIR A;  4MZO A;  2AS8 A;  2O6X A;  4CDC B;  4AXM A;  2DC6 A;  3H6S A;  3KWB X;  1BGO A;  2DJF B;  1BY8 A;  2G8E A;  3HHA A;  1MHW A;  4YYU A;  2IBI A;  1KFU L;  5CVN B;  1CSB B;  3DF0 A;  4BQV A;  1QDQ A;  3NHE A;  4BS6 A;  1NQC A;  1O0E A;  2JQG R;  1PPO A;  3OIS A;  2G6D A;  1KFX L;  4QRG A;  3HD3 A;  3MHH A;  1MEM A;  1QXP A;  4PAD A;  1ATK A;  1PPD A;  2G7Y A;  2BDL A;  3GCB A;  3I06 A;  1KXR A;  4PP1 A;  3LFY A;  1K3B B;  1PAD A;  1CQD A;  1DEU A;  2AIM A;  2YJB A;  3KW9 A;  2DZZ A;  1KHQ A;  2Y6E A;  4MZS A;  3S3R A;  3KWZ A;  4N79 A;  3K9M A;  3BPM A;  1NPZ A;  2AVW A;  4I07 A;  3BWK A;  3RVW A;  4YV8 A;  5F02 A;  1CV8 A;  2C0Y A;  4ZUX U;  2DC7 A;  2AU1 A;  4YYQ A;  2H7J A;  1BQI A;  3H8B A;  3P5X A;  1MDW A;  1F2A A;  1U9W A;  4OEL A;  1CTE A;  2PRE A;  3BOW A;  5K16 A;  5FPW A;  4K7C A;  3N3G A;  3N4C A;  2ARY A;  4XR7 A;  2FTD A;  2R9C A;  5PAD A;  3WXE A;  1YT7 A;  1EF7 A;  3OF8 A;  4MSX A;  2VHS A;  6PAD A;  4N4Z A;  3BCN A;  4Q8G A;  3O1G A;  3M99 A;  1MEG A;  3ZUA A;  3V6E A;  2YJ9 A;  2YJ8 A;  2E02 A;  2ATO A;  1EWM A;  1Y08 A;  4W5B A;  4W4U A;  1ME4 A;  4YVA A;  3O0U A;  2GFO A;  3OVZ A;  1S4V A;  3WXG A;  3AI8 A;  2FRA A;  2AYN A;  2F1G A;  3P5W A;  2XU5 A;  2FT2 A;  3HHI A;  4HWY A;  1CJL A;  1HUC B;  1JQP A;  1XKG A;  2AUX A;  3U8E A;  1MS6 A;  2DCD A;  3IHP A;  4YYW A;  3HWN A;  1PE6 A;  1M6D A;  2YJ2 A;  3F75 A;  2XU1 A;  2P7U A;  3KSE A;  1A6R A;  5CHV A;  2P0R A;  2R9M A;  1ME3 A;  2FO5 A;  1PBH A;  2R9N A;  1VJV A;  2DJG B;  2WBF X;  2B1M A;  1Q6K A;  1AU2 A;  3CH3 X;  4QH6 A;  4BSQ A;  3BC3 A;  1YK8 A;  4X6I A;  3USV A;  1PPN A;  2HD5 A;  2DCB A;  1AEC A;  3OVX A;  4AXL A;  2XU4 A;  1GMY A;  5CVM A;  2E03 A;  3N3K A;  3CBK A;  3P5U A;  2HHN A;  4DMY A;  4I05 A;  1THE A;  3IV2 A;  2E00 A;  1AU0 A;  1ICF A;  2FQ9 A;  4CZW A;  4G54 A;  3IMA A;  1FH0 A;  3C9E A;  1AYV A;  4BPV A;  4CDF B;  1F2C A;  1YK7 A;  2R9F A;  4P6G A;  9PAP A;  2HH5 A;  4XUI A;  1U5I A;  3QSD A;  2GHU A;  2E01 A;  4X6H A;  3ERV A;  2FRQ A;  3QJ3 A;  4DMX A;  3V6C A;  1U9Q X;  4YYR A;  2Y5B A;  3IOQ A;  4FJC A;  1F2B A;  2OP3 A;  4RY2 A;  4Q8H A;  5EGW A;  3E1Z B;  3TNX A;  1X9Y A;  3MHS A;  1ZCM A;  3H89 A;  2R6N A;  3PW3 A;  1YAL A;  2AUZ A;  2CB5 A;  1IWD A;  1TU6 A;  2CIO A;  3F5V A;  2XU3 A;  1CPJ A;  1EWP A;  4WA6 A;  1GEC E;  3MTN A;  2IPP B;  4CDD B;  3IEJ A;  2AYO A;  1BP4 A;  4I04 A;  1CS8 A;  3LXS A;  2PAD A;  1U9X A;  3CH2 X;  2G8J A;  3K24 A;  3KKU A;  2DC8 A;  1CVZ A;  2NQA A;  3BPF A;  1GCB A;  1EWL A;  1NL6 A;  1Y4H A;  2P86 A;  1F29 A;  4X6J A;  3CBJ A;  1STF E;  1PIP A;  1AU3 A;  1QOL A;  3D6S A;  2DC9 A;  3I3T A;  5A24 A;  3H8C A;  4OEM A;  4N8W A; 
#chains in the Genus database with same CATH topology
 2OUL A;  3TRK A;  1PXV A;  4PI3 A;  4BS5 A;  1TL9 A;  2B1N A;  4ZTB A;  5EZQ A;  1TLO A;  1SP4 B;  3P5V A;  4W5C A;  2NQG A;  2NQD B;  3OF9 A;  1ITO A;  3B79 A;  3IUT A;  3K8U A;  2JRI A;  2F7D A;  2NQI A;  1AYU A;  2YJC A;  3KFQ A;  1ZIV A;  2PBH A;  1GLO A;  1SNK A;  4BOU A;  1NLJ A;  5JH3 A;  1PCI A;  2FE8 A;  1EWO A;  1QMY A;  1U9V A;  2DCC A;  5JZE A;  3H7D A;  3RVV A;  4QRX A;  3PBH A;  4RF1 A;  3WXF A;  5JA7 A;  4CDE B;  4BOQ A;  1DF0 A;  4QRV A;  3S3Q A;  4QBB A;  1AYW A;  3QT4 A;  2ACT A;  4RKX A;  7PCK A;  1NB5 A;  1AIM A;  8PCH A;  1POP A;  2HXZ A;  2BDZ A;  1NB3 A;  1KHP A;  5CHT A;  4FIP A;  4KLB A;  4D8I A;  5J94 A;  2FUD A;  2DCA A;  1CB5 A;  2JQF R;  4OVZ A;  3MOR A;  2OZ2 A;  1YVB A;  1PPP A;  2FYE A;  1VSN A;  3PNR A;  4YYV A;  2DZY A;  5EF4 A;  2VHF A;  2PNS A;  4YYS A;  4PP2 E;  4XZX A;  2R9O A;  1AU4 A;  5E6J A;  5CVO B;  4P6E A;  4FK5 A;  3RVX A;  3PDF A;  3KX1 A;  1MIR A;  4MZO A;  2AS8 A;  2O6X A;  4CDC B;  1DKI A;  4AXM A;  2DC6 A;  3H6S A;  3KWB X;  1BGO A;  2J7Q C;  2DJF B;  1BY8 A;  4IP3 A;  2G8E A;  3HHA A;  1MHW A;  4YYU A;  2IBI A;  1KFU L;  5CVN B;  1CSB B;  3W31 A;  3DF0 A;  4BQV A;  1QDQ A;  4MM3 B;  3NHE A;  4BS6 A;  1NQC A;  1O0E A;  2JQG R;  1PPO A;  4OW0 A;  3OIS A;  2G6D A;  1KFX L;  4QRG A;  3HD3 A;  4RNA A;  3C0R A;  3MHH A;  3TMP A;  1MEM A;  1QXP A;  4PAD A;  4RF0 A;  1ATK A;  1PPD A;  2G7Y A;  2BDL A;  3GCB A;  3I06 A;  1KXR A;  4WUR A;  4MI7 A;  4PP1 A;  3LFY A;  1K3B B;  1PAD A;  1CQD A;  1DEU A;  2AIM A;  2YJB A;  3KW9 A;  3O65 A;  2DZZ A;  1KHQ A;  2Y6E A;  4MZS A;  3S3R A;  3KWZ A;  4N79 A;  3K9M A;  3BPM A;  1NPZ A;  2AVW A;  4I07 A;  3BWK A;  3RVW A;  4YV8 A;  5F02 A;  3MTV A;  1CV8 A;  4BOZ A;  1YZB A;  2C0Y A;  2Z84 A;  3BY4 A;  4ZUX U;  3ZNH A;  2DC7 A;  2AU1 A;  4YYQ A;  2H7J A;  1BQI A;  3H8B A;  4M0W A;  3P5X A;  1MDW A;  1F2A A;  1U9W A;  4OEL A;  1CTE A;  2PRE A;  3BOW A;  5K16 A;  5FPW A;  4K7C A;  3N3G A;  3N4C A;  2ARY A;  4XR7 A;  2FTD A;  2R9C A;  5PAD A;  2J7Q A;  3WXE A;  1YT7 A;  1EF7 A;  3OF8 A;  3B21 A;  4MSX A;  2VHS A;  3IFU A;  6PAD A;  4N4Z A;  4BOP A;  3BCN A;  3OQC A;  4Q8G A;  3O1G A;  3M99 A;  1MEG A;  3ZUA A;  3V6E A;  2YJ9 A;  2YJ8 A;  2E02 A;  2ATO A;  1EWM A;  1Y08 A;  4W5B A;  4W4U A;  1ME4 A;  4YVA A;  3O0U A;  2GFO A;  3OVZ A;  1S4V A;  3WXG A;  3AI8 A;  2BTW B;  3PRP A;  2FRA A;  1UKF A;  2AYN A;  2F1G A;  3P5W A;  2XU5 A;  2FT2 A;  3HHI A;  4HWY A;  1CJL A;  1HUC B;  1JQP A;  1XKG A;  2AUX A;  3U8E A;  1MS6 A;  3MP2 A;  2DCD A;  3IHP A;  4YYW A;  3HWN A;  1PE6 A;  4D8E A;  1M6D A;  2YJ2 A;  3F75 A;  2XU1 A;  2P7U A;  3KSE A;  1A6R A;  5CHV A;  2P0R A;  2R9M A;  1ME3 A;  2FO5 A;  1PBH A;  2R9N A;  2UZJ A;  1VJV A;  2DJG B;  2WBF X;  2B1M A;  1Q6K A;  1AU2 A;  3CH3 X;  4QH6 A;  4BSQ A;  3BC3 A;  1YK8 A;  4D8B A;  4GUA A;  4X6I A;  3USV A;  1PPN A;  2HD5 A;  2DCB A;  2JTC A;  1AEC A;  2AGA A;  3OVX A;  4AXL A;  2XU4 A;  1GMY A;  5CVM A;  2E03 A;  3RNV A;  3N3K A;  3CBK A;  3P5U A;  2HHN A;  3BB7 A;  4DMY A;  3PHU A;  4REZ A;  4R3D A;  4I05 A;  1THE A;  3PT2 A;  3IV2 A;  2E00 A;  2HWK A;  1AU0 A;  1ICF A;  2FQ9 A;  4CZW A;  4IUM A;  4G54 A;  3IMA A;  2DOS A;  1FH0 A;  3C9E A;  1AYV A;  4BPV A;  4CDF B;  3PHW A;  1F2C A;  1YK7 A;  2R9F A;  4P6G A;  1PVJ A;  9PAP A;  2HH5 A;  4XUI A;  1U5I A;  3QSD A;  3PSE A;  2GHU A;  2E01 A;  4X6H A;  3ERV A;  2FRQ A;  3QJ3 A;  4DMX A;  2BTW A;  3V6C A;  1U9Q X;  4YYR A;  3BBA A;  2Y5B A;  3IOQ A;  4FJC A;  1F2B A;  2OP3 A;  3PRM A;  4RY2 A;  4Q8H A;  5EGW A;  3E1Z B;  3TNX A;  1X9Y A;  3MHS A;  4P16 A;  1ZCM A;  3H89 A;  2R6N A;  3PW3 A;  3E9S A;  1YAL A;  2AUZ A;  2CB5 A;  4PT5 A;  5EZS A;  1IWD A;  1TU6 A;  2CIO A;  3F5V A;  2XU3 A;  1CPJ A;  4OVZ B;  2BU3 A;  1EWP A;  4WA6 A;  1GEC E;  3MTN A;  2IPP B;  4CDD B;  3IEJ A;  2AYO A;  1BP4 A;  4I04 A;  1CS8 A;  3LXS A;  2PAD A;  1U9X A;  3CH2 X;  2G8J A;  3K24 A;  3KKU A;  3MJ5 A;  2DC8 A;  4HXD B;  1CVZ A;  2NQA A;  3BPF A;  1GCB A;  4BOS A;  1EWL A;  3PHX A;  1NL6 A;  1Y4H A;  2P86 A;  1F29 A;  4X6J A;  4A5U A;  3W30 A;  3CBJ A;  1STF E;  1PIP A;  1AU3 A;  1QOL A;  3D6S A;  2DC9 A;  3I3T A;  5KO3 A;  5A24 A;  3H8C A;  4OEM A;  4N8W A; 
#chains in the Genus database with same CATH homology
 2OUL A;  1PXV A;  4PI3 A;  4BS5 A;  1TL9 A;  2B1N A;  1TLO A;  1SP4 B;  3P5V A;  4W5C A;  2NQG A;  2NQD B;  3OF9 A;  1ITO A;  3B79 A;  3IUT A;  3K8U A;  2F7D A;  2NQI A;  1AYU A;  2YJC A;  3KFQ A;  1ZIV A;  2PBH A;  1GLO A;  1SNK A;  1NLJ A;  5JH3 A;  1PCI A;  1EWO A;  1QMY A;  1U9V A;  2DCC A;  3H7D A;  3RVV A;  4QRX A;  3PBH A;  3WXF A;  5JA7 A;  4CDE B;  1DF0 A;  4QRV A;  3S3Q A;  4QBB A;  1AYW A;  3QT4 A;  2ACT A;  7PCK A;  1NB5 A;  1AIM A;  8PCH A;  1POP A;  2HXZ A;  2BDZ A;  1NB3 A;  1KHP A;  5CHT A;  4FIP A;  4KLB A;  5J94 A;  2FUD A;  2DCA A;  1CB5 A;  2JQF R;  3MOR A;  2OZ2 A;  1YVB A;  1PPP A;  2FYE A;  1VSN A;  3PNR A;  4YYV A;  2DZY A;  5EF4 A;  2VHF A;  1W5R A;  2PNS A;  4YYS A;  4PP2 E;  2R9O A;  1AU4 A;  5CVO B;  4P6E A;  4FK5 A;  3RVX A;  3PDF A;  3KX1 A;  1MIR A;  4MZO A;  2AS8 A;  2O6X A;  4CDC B;  4AXM A;  2DC6 A;  3H6S A;  3KWB X;  1BGO A;  2DJF B;  1BY8 A;  2G8E A;  3HHA A;  1MHW A;  4YYU A;  2IBI A;  1KFU L;  5CVN B;  1CSB B;  3DF0 A;  4BQV A;  1QDQ A;  3NHE A;  4BS6 A;  1NQC A;  1O0E A;  1W6F A;  2JQG R;  1PPO A;  3OIS A;  2G6D A;  1KFX L;  4QRG A;  3HD3 A;  3MHH A;  1MEM A;  1QXP A;  4PAD A;  2VFB A;  1ATK A;  1PPD A;  2G7Y A;  2BDL A;  3GCB A;  3I06 A;  1KXR A;  4PP1 A;  3LFY A;  1K3B B;  1PAD A;  1CQD A;  1DEU A;  2AIM A;  2YJB A;  3KW9 A;  2DZZ A;  1KHQ A;  2Y6E A;  4MZS A;  3S3R A;  1E2T A;  3KWZ A;  4N79 A;  3K9M A;  3BPM A;  1NPZ A;  2AVW A;  4I07 A;  3BWK A;  3RVW A;  4YV8 A;  5F02 A;  1CV8 A;  2C0Y A;  4ZUX U;  2DC7 A;  2AU1 A;  4YYQ A;  2H7J A;  1BQI A;  4NV8 A;  3H8B A;  3P5X A;  1MDW A;  1F2A A;  1U9W A;  4OEL A;  1CTE A;  2PRE A;  3BOW A;  5K16 A;  5FPW A;  4K7C A;  3N3G A;  3N4C A;  2ARY A;  4XR7 A;  2FTD A;  2R9C A;  5PAD A;  3WXE A;  1YT7 A;  1EF7 A;  3OF8 A;  4MSX A;  2VHS A;  4NV7 A;  6PAD A;  3LTW A;  4N4Z A;  4BGF A;  3D9W A;  3BCN A;  4Q8G A;  3O1G A;  3M99 A;  1MEG A;  3ZUA A;  3V6E A;  2YJ9 A;  2YJ8 A;  2E02 A;  2ATO A;  1EWM A;  1Y08 A;  4W5B A;  4W4U A;  1ME4 A;  4YVA A;  3O0U A;  2GFO A;  2VFC A;  3OVZ A;  1S4V A;  3WXG A;  3AI8 A;  2FRA A;  2AYN A;  2F1G A;  3P5W A;  2XU5 A;  2FT2 A;  3HHI A;  4HWY A;  1CJL A;  1HUC B;  1JQP A;  1XKG A;  2AUX A;  3U8E A;  1MS6 A;  2DCD A;  3IHP A;  4YYW A;  3HWN A;  1PE6 A;  1M6D A;  2YJ2 A;  3F75 A;  2XU1 A;  2P7U A;  3KSE A;  1A6R A;  5CHV A;  2P0R A;  2R9M A;  1ME3 A;  2FO5 A;  1PBH A;  2R9N A;  1VJV A;  2DJG B;  2WBF X;  2B1M A;  1Q6K A;  1AU2 A;  3CH3 X;  4QH6 A;  4BSQ A;  3BC3 A;  1YK8 A;  4X6I A;  3USV A;  1PPN A;  2HD5 A;  2DCB A;  1AEC A;  3OVX A;  4AXL A;  2XU4 A;  1GMY A;  5CVM A;  2E03 A;  3N3K A;  3CBK A;  3P5U A;  4B55 A;  2HHN A;  4DMY A;  4I05 A;  1THE A;  3IV2 A;  2E00 A;  1W4T A;  1AU0 A;  1ICF A;  2FQ9 A;  4CZW A;  4C5P A;  4G54 A;  4GUZ A;  3IMA A;  1FH0 A;  3C9E A;  1AYV A;  4BPV A;  4CDF B;  1F2C A;  1YK7 A;  2R9F A;  4P6G A;  9PAP A;  2HH5 A;  4XUI A;  1U5I A;  3QSD A;  2GHU A;  2E01 A;  4X6H A;  3ERV A;  2FRQ A;  3QJ3 A;  4DMX A;  3V6C A;  1U9Q X;  4YYR A;  2Y5B A;  3IOQ A;  4FJC A;  1F2B A;  2OP3 A;  4RY2 A;  4Q8H A;  5EGW A;  3E1Z B;  3TNX A;  1X9Y A;  3MHS A;  1ZCM A;  3H89 A;  2R6N A;  3PW3 A;  1YAL A;  2AUZ A;  2CB5 A;  1IWD A;  1TU6 A;  2CIO A;  3F5V A;  2XU3 A;  1CPJ A;  1GX3 A;  1EWP A;  4WA6 A;  1GEC E;  3MTN A;  2IPP B;  4CDD B;  3IEJ A;  2AYO A;  1BP4 A;  4I04 A;  1CS8 A;  2BSZ A;  3LXS A;  2PAD A;  1U9X A;  3CH2 X;  2G8J A;  3K24 A;  3KKU A;  2DC8 A;  1CVZ A;  2NQA A;  3BPF A;  1GCB A;  1EWL A;  1NL6 A;  1Y4H A;  2P86 A;  1F29 A;  4X6J A;  3CBJ A;  1STF E;  1PIP A;  1AU3 A;  1QOL A;  3D6S A;  2DC9 A;  3I3T A;  5A24 A;  3H8C A;  4OEM A;  4N8W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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