3IUTA

The crystal structure of cruzain in complex with a tetrafluorophenoxymethyl ketone inhibitor
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLAEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDGAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for chagas disease chemotherapy.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma cruzi
molecule keywords Cruzipain
total genus 68
structure length 215
sequence length 215
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2009-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 3iutA00
3KX1A 3AI8A 2PBHA 1GECE 3WXEA 2CIOA 2OP3A 3B79A 1Y08A 4PADA 4X6JA 2HH5A 2BDZA 3I3TA 4PP1A 4OEMA 3V6EA 2AYNA 3BCNA 4QH6A 2OZ2A 4MSXA 4FIPA 4YV8A 2E00A 3U8EA 1AU2A 4BS6A 4YYSA 1ZIVA 2ARYA 2CB5A 2JQGR 1KHPA 1F2CA 1F29A 3CBJA 4QRGA 2E03A 1YALA 2AUXA 4YYWA 3K8UA 2XU1A 3P5VA 2AU1A 3O0UA 5CVOB 1PPOA 4AXMA 2DCBA 4BQVA 3IOQA 3H7DA 4FK5A 1EF7A 1U9QX 1PXVA 2R9OA 1ATKA 3WXGA 1AYUA 3CH3X 1DEUA 1U5IA 4W5BA 1TU6A 4P6GA 2DCCA 1QOLA 2E02A 4ZUXU 4HWYA 1BP4A 2G7YA 3OISA 2DZYA 4QRVA 1SNKA 1AIMA 3BPMA 4YYRA 2YJ9A 2DJFB 5EF4A 3DF0A 3PW3A 1FH0A 2PREA 4MZSA 4WA6A 2AUZA 2YJCA 1AECA 3KWZA 1STFE 2DC7A 2FYEA 1EWMA 4G54A 4I04A 3QSDA 4AXLA 1KXRA 3KWBX 1S4VA 4K7CA 3USVA 1BY8A 2XU3A 5JA7A 2DJGB 3H89A 1PPPA 2F1GA 3M99A 2AVWA 3N3GA 2Y6EA 3QJ3A 3K24A 4PI3A 3CH2X 3BOWA 1X9YA 5K16A 1CSBB 3IUTA 4W5CA 2ACTA 2O6XA 1VJVA 2DCDA 1EWOA 1KFUL 5CVMA 4XUIA 4RY2A 1GLOA 2G8EA 2AS8A 5JH3A 3MTNA 2YJ2A 2R9CA 3O1GA 1AYWA 2P86A 1YK8A 3RVXA 4XR7A 3F5VA 2G6DA 2VHSA 3MORA 1JQPA 2P0RA 3BPFA 1YT7A 4Q8GA 2H7JA 3IEJA 2XU4A 1A6RA 3BC3A 1TL9A 4QRXA 3KKUA 1PADA 1AYVA 4I07A 1CQDA 2HD5A 4CDFB 1PE6A 2GFOA 2IPPB 2R9NA 2C0YA 2AIMA 3IMAA 2VHFA 1CB5A 2Y5BA 2B1NA 1EWPA 1O0EA 1KFXL 2P7UA 2R6NA 3N3KA 3IV2A 5CVNB 1VSNA 2FTDA 1NQCA 3S3QA 1YVBA 3OVXA 1NB3A 1PIPA 3BWKA 5J94A 1THEA 2FQ9A 3MHHA 1AU0A 3F75A 1F2BA 9PAPA 3QT4A 3LXSA 1KHQA 1MHWA 3PBHA 1POPA 3ERVA 3LFYA 6PADA 4YVAA 1AU3A 3N4CA 1PCIA 4FJCA 2NQGA 1CJLA 3ZUAA 5EGWA 4KLBA 1GCBA 2DC9A 3KFQA 2FUDA 3PNRA 5F02A 2OULA 3IHPA 2WBFX 2FO5A 1K3BB 1QXPA 3S3RA 5FPWA 4YYUA 3E1ZB 7PCKA 4DMXA 1BGOA 3OF9A 1Y4HA 4YYVA 3RVWA 1EWLA 3I06A 1PBHA 1NL6A 2DCAA 1IWDA 2XU5A 2B1MA 3K9MA 2DC8A 3PDFA 1QDQA 3RVVA 1U9VA 3NHEA 1MEGA 1QMYA 3V6CA 3CBKA 5CHTA 1NLJA 4PP2E 4CDEB 3TNXA 2R9MA 1F2AA 3HHAA 1ITOA 1SP4B 1MDWA 3P5WA 4I05A 3H6SA 1AU4A 1NB5A 1TLOA 3H8CA 2IBIA 2YJBA 1CPJA 3C9EA 4N8WA 4OELA 1PPDA 2BDLA 8PCHA 3GCBA 1CS8A 1YK7A 4P6EA 4X6HA 3WXFA 2FRQA 3HWNA 1PPNA 1DF0A 4CDCB 2FT2A 1U9WA 1ME3A 3MHSA 4X6IA 4N4ZA 2HXZA 1ICFA 4YYQA 4BSQA 2AYOA 3P5UA 3HHIA 3H8BA 1CTEA 2DZZA 2PNSA 1MIRA 2NQAA 5PADA 3KW9A 1HUCB 3OF8A 4CDDB 4QBBA 2F7DA 2G8JA 3P5XA 1ME4A 1GMYA 2R9FA 4W4UA 4BS5A 1BQIA 1ZCMA 2ATOA 2NQDB 2NQIA 3OVZA 1CV8A 1M6DA 4MZOA 1CVZA 1MS6A 2DC6A 2GHUA 2YJ8A 3HD3A 1U9XA 2FRAA 5A24A 4CZWA 2JQFR 1MEMA 5CHVA 2PADA 2HHNA 1NPZA 4N79A 4BPVA 1Q6KA 2E01A 1XKGA 3D6SA 4DMYA 4Q8HA 3KSEA
chains in the Genus database with same CATH superfamily
3KX1A 3AI8A 2PBHA 1GECE 3WXEA 2CIOA 2OP3A 4D8BA 3B79A 1Y08A 4PADA 4X6JA 2HH5A 2BDZA 3I3TA 4PP1A 4OEMA 3V6EA 3BB7A 2AYNA 3BCNA 4QH6A 2OZ2A 4MSXA 4FIPA 4YV8A 2E00A 3U8EA 1AU2A 4BS6A 4YYSA 3ZNHA 1ZIVA 2ARYA 2CB5A 2JQGR 4BOQA 1KHPA 1F2CA 1F29A 4MI7A 3CBJA 4QRGA 2E03A 1YALA 2AUXA 2BTWA 3K8UA 4BOZA 4YYWA 2XU1A 3P5VA 2AU1A 3O0UA 5CVOB 1PPOA 4AXMA 2DCBA 4BQVA 3IOQA 3C0RA 3H7DA 2HWKA 4FK5A 1EF7A 4MM3B 1U9QX 1PXVA 2R9OA 1ATKA 3E9SA 3WXGA 1AYUA 3CH3X 1DEUA 1U5IA 4W5BA 1TU6A 4P6GA 2DCCA 1QOLA 2E02A 4ZUXU 4HWYA 1BP4A 2G7YA 3OISA 2DZYA 4QRVA 4IUMA 1SNKA 1AIMA 3BPMA 4YYRA 2YJ9A 2DJFB 5EZQA 2JTCA 5EF4A 3DF0A 3PW3A 1FH0A 2PREA 4MZSA 4WA6A 4D8IA 2AUZA 2YJCA 4BOSA 1AECA 3KWZA 1STFE 2DC7A 2FYEA 1EWMA 4G54A 3PHUA 4I04A 3QSDA 4AXLA 1KXRA 3KWBX 1S4VA 4K7CA 3USVA 1BY8A 2XU3A 4GUAA 5JA7A 2DJGB 3H89A 1PPPA 2F1GA 3M99A 3MTVA 2AVWA 4P16A 2AGAA 3N3GA 5EZSA 2Y6EA 5E6JA 3QJ3A 4REZA 3K24A 4PI3A 3CH2X 3BY4A 3BOWA 1X9YA 5K16A 1CSBB 3IUTA 1PVJA 4W5CA 2ACTA 2O6XA 1VJVA 2DCDA 1EWOA 1KFUL 5CVMA 2BTWB 4XUIA 4RY2A 1GLOA 2G8EA 2AS8A 5JH3A 3MTNA 2YJ2A 2R9CA 3O1GA 1AYWA 2P86A 1YK8A 3RVXA 4XR7A 3F5VA 2G6DA 3BBAA 2VHSA 3MORA 4OW0A 1JQPA 2P0RA 3BPFA 1YT7A 4Q8GA 2H7JA 3IEJA 2XU4A 1A6RA 3BC3A 1TL9A 4QRXA 3KKUA 3PRMA 1PADA 1AYVA 4I07A 4BOPA 1CQDA 2HD5A 4CDFB 1PE6A 2GFOA 2IPPB 2R9NA 2C0YA 2AIMA 3IMAA 2VHFA 1DKIA 1CB5A 2Y5BA 2B1NA 1EWPA 1O0EA 1KFXL 2P7UA 2R6NA 3N3KA 3IV2A 5CVNB 1VSNA 2FTDA 1NQCA 3S3QA 1YVBA 3OVXA 3RNVA 1NB3A 1PIPA 3BWKA 5J94A 1THEA 2FQ9A 3MHHA 1AU0A 3F75A 1F2BA 9PAPA 3QT4A 3LXSA 1KHQA 1MHWA 3PBHA 3W31A 3W30A 1POPA 3ERVA 3LFYA 6PADA 4YVAA 4WURA 4PT5A 1AU3A 3N4CA 1PCIA 4FJCA 2NQGA 4RKXA 1CJLA 4HXDB 3ZUAA 5EGWA 4KLBA 2DOSA 1GCBA 2DC9A 3KFQA 2FUDA 3PNRA 4RNAA 5F02A 2OULA 3IHPA 3IFUA 2WBFX 2FO5A 5JZEA 1K3BB 1QXPA 3S3RA 5FPWA 4YYUA 3E1ZB 2BU3A 3TMPA 7PCKA 3PHWA 3PSEA 4DMXA 1BGOA 3OF9A 4XZXA 1Y4HA 4YYVA 3RVWA 1EWLA 3I06A 1PBHA 1NL6A 2DCAA 1IWDA 2XU5A 4M0WA 4IP3A 2Z84A 2B1MA 3K9MA 2DC8A 3PDFA 1QDQA 3RVVA 2FE8A 4BOUA 1U9VA 3NHEA 4OVZA 1MEGA 1QMYA 3V6CA 3CBKA 5CHTA 1NLJA 3MJ5A 4PP2E 4CDEB 3B21A 3TNXA 2J7QA 2R9MA 3PHXA 1F2AA 3HHAA 3MP2A 2J7QC 1ITOA 1SP4B 1MDWA 5KO3A 3P5WA 3H6SA 4I05A 1AU4A 1NB5A 1TLOA 4A5UA 3H8CA 2IBIA 2YJBA 1CPJA 3C9EA 4N8WA 4OELA 1PPDA 2BDLA 1YZBA 8PCHA 3GCBA 1CS8A 1YK7A 4P6EA 4X6HA 3WXFA 2FRQA 3HWNA 1PPNA 1DF0A 4CDCB 2FT2A 1U9WA 1ME3A 3PT2A 3MHSA 4X6IA 4N4ZA 2HXZA 1ICFA 4YYQA 1UKFA 4BSQA 4R3DA 2UZJA 2AYOA 3P5UA 3HHIA 3H8BA 4ZTBA 1CTEA 2DZZA 2PNSA 1MIRA 2NQAA 2JRIA 5PADA 4RF1A 3KW9A 1HUCB 3OF8A 4CDDB 4QBBA 2F7DA 2G8JA 3P5XA 1ME4A 1GMYA 2R9FA 4W4UA 4BS5A 1BQIA 1ZCMA 3OQCA 2ATOA 2NQDB 2NQIA 4D8EA 3OVZA 1CV8A 3PRPA 1M6DA 4MZOA 1CVZA 1MS6A 2DC6A 2GHUA 2YJ8A 3HD3A 1U9XA 3O65A 2FRAA 5A24A 4OVZB 4CZWA 2JQFR 1MEMA 4RF0A 5CHVA 2PADA 2HHNA 1NPZA 4N79A 4BPVA 1Q6KA 2E01A 1XKGA 3D6SA 4DMYA 4Q8HA 3KSEA 3TRKA
chains in the Genus database with same CATH topology
3KX1A 3AI8A 2PBHA 1GECE 3WXEA 2CIOA 2OP3A 3B79A 1Y08A 4PADA 4X6JA 2HH5A 2BDZA 3I3TA 4PP1A 4OEMA 3V6EA 2AYNA 3BCNA 4QH6A 2OZ2A 4MSXA 4FIPA 4YV8A 2E00A 3U8EA 1AU2A 4BS6A 4YYSA 1ZIVA 2ARYA 2CB5A 2JQGR 1KHPA 1W5RA 1F2CA 1F29A 3CBJA 4QRGA 2E03A 1YALA 2AUXA 4YYWA 3K8UA 2XU1A 3P5VA 2AU1A 3O0UA 5CVOB 3D9WA 1PPOA 4AXMA 2DCBA 4BQVA 3IOQA 3H7DA 4FK5A 1EF7A 1U9QX 1PXVA 2R9OA 1W4TA 1ATKA 3WXGA 1AYUA 3CH3X 1DEUA 1U5IA 4W5BA 1TU6A 4P6GA 2DCCA 1QOLA 2E02A 4ZUXU 4HWYA 1BP4A 2G7YA 3OISA 2DZYA 4QRVA 1SNKA 1AIMA 3BPMA 4YYRA 2YJ9A 2DJFB 5EF4A 3DF0A 3PW3A 1FH0A 2PREA 4MZSA 4WA6A 2AUZA 2YJCA 1AECA 3KWZA 1STFE 2DC7A 2FYEA 1EWMA 4G54A 4I04A 3QSDA 4AXLA 1KXRA 3KWBX 1S4VA 4K7CA 3USVA 1BY8A 2XU3A 5JA7A 2DJGB 3H89A 1PPPA 2F1GA 3M99A 2AVWA 3N3GA 2Y6EA 3QJ3A 3K24A 4PI3A 3CH2X 3BOWA 1X9YA 5K16A 1CSBB 3IUTA 4W5CA 2ACTA 2O6XA 1VJVA 2DCDA 1EWOA 1KFUL 5CVMA 4XUIA 4RY2A 1GLOA 2G8EA 2AS8A 5JH3A 3MTNA 2YJ2A 2R9CA 3O1GA 1AYWA 2P86A 1YK8A 3RVXA 4XR7A 3F5VA 2G6DA 2VHSA 3MORA 1JQPA 2P0RA 3BPFA 1YT7A 4Q8GA 2H7JA 2VFBA 3IEJA 2XU4A 1A6RA 3BC3A 1TL9A 4QRXA 3KKUA 1PADA 1AYVA 4I07A 1CQDA 2HD5A 4CDFB 1PE6A 2GFOA 2IPPB 2R9NA 2C0YA 2AIMA 3IMAA 1W6FA 2VHFA 1CB5A 2Y5BA 2B1NA 1EWPA 1O0EA 2VFCA 1KFXL 4NV7A 2P7UA 2R6NA 3N3KA 3IV2A 5CVNB 1VSNA 2FTDA 1NQCA 3S3QA 1YVBA 3OVXA 1NB3A 1PIPA 3BWKA 5J94A 3LTWA 1THEA 2FQ9A 3MHHA 1AU0A 3F75A 1F2BA 9PAPA 3QT4A 3LXSA 1KHQA 1MHWA 3PBHA 1POPA 3ERVA 3LFYA 6PADA 4YVAA 1AU3A 3N4CA 1PCIA 4FJCA 2NQGA 1CJLA 3ZUAA 5EGWA 4KLBA 1GCBA 2DC9A 3KFQA 2FUDA 3PNRA 5F02A 2OULA 3IHPA 4BGFA 1GX3A 2WBFX 2FO5A 1K3BB 1QXPA 3S3RA 5FPWA 4YYUA 3E1ZB 7PCKA 4DMXA 4C5PA 1BGOA 3OF9A 1Y4HA 4YYVA 3RVWA 1EWLA 3I06A 1PBHA 1NL6A 2DCAA 1IWDA 2XU5A 2B1MA 3K9MA 2DC8A 3PDFA 1QDQA 3RVVA 1U9VA 3NHEA 1MEGA 1QMYA 3V6CA 3CBKA 5CHTA 1NLJA 4PP2E 4CDEB 3TNXA 2R9MA 1F2AA 3HHAA 1ITOA 1SP4B 1MDWA 3P5WA 4I05A 3H6SA 1AU4A 1NB5A 1TLOA 2BSZA 3H8CA 2IBIA 2YJBA 1CPJA 3C9EA 4N8WA 4OELA 1PPDA 2BDLA 8PCHA 3GCBA 1CS8A 1YK7A 4P6EA 4X6HA 3WXFA 2FRQA 3HWNA 1PPNA 1DF0A 4CDCB 2FT2A 1U9WA 1ME3A 3MHSA 4X6IA 4N4ZA 2HXZA 1ICFA 4YYQA 4BSQA 2AYOA 3P5UA 3HHIA 3H8BA 1CTEA 4B55A 1E2TA 2DZZA 2PNSA 1MIRA 2NQAA 5PADA 3KW9A 1HUCB 3OF8A 4CDDB 4QBBA 2F7DA 2G8JA 3P5XA 1ME4A 1GMYA 2R9FA 4W4UA 4BS5A 1BQIA 1ZCMA 2ATOA 2NQDB 2NQIA 3OVZA 1CV8A 1M6DA 4MZOA 1CVZA 1MS6A 2DC6A 2GHUA 2YJ8A 3HD3A 1U9XA 2FRAA 5A24A 4CZWA 2JQFR 1MEMA 4GUZA 4NV8A 5CHVA 2PADA 2HHNA 1NPZA 4N79A 4BPVA 1Q6KA 2E01A 1XKGA 3D6SA 4DMYA 4Q8HA 3KSEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KX1 A;  3AI8 A;  2PBH A;  1GEC E;  3WXE A;  2CIO A;  2OP3 A;  3B79 A;  1Y08 A;  4PAD A;  4X6J A;  2HH5 A;  2BDZ A;  3I3T A;  4PP1 A;  4OEM A;  3V6E A;  2AYN A;  3BCN A;  4QH6 A;  2OZ2 A;  4MSX A;  4FIP A;  4YV8 A;  2E00 A;  3U8E A;  1AU2 A;  4BS6 A;  4YYS A;  1ZIV A;  2ARY A;  2CB5 A;  2JQG R;  1KHP A;  1F2C A;  1F29 A;  3CBJ A;  4QRG A;  2E03 A;  1YAL A;  2AUX A;  4YYW A;  3K8U A;  2XU1 A;  3P5V A;  2AU1 A;  3O0U A;  5CVO B;  1PPO A;  4AXM A;  2DCB A;  4BQV A;  3IOQ A;  3H7D A;  4FK5 A;  1EF7 A;  1U9Q X;  1PXV A;  2R9O A;  1ATK A;  3WXG A;  1AYU A;  3CH3 X;  1DEU A;  1U5I A;  4W5B A;  1TU6 A;  4P6G A;  2DCC A;  1QOL A;  2E02 A;  4ZUX U;  4HWY A;  1BP4 A;  2G7Y A;  3OIS A;  2DZY A;  4QRV A;  1SNK A;  1AIM A;  3BPM A;  4YYR A;  2YJ9 A;  2DJF B;  5EF4 A;  3DF0 A;  3PW3 A;  1FH0 A;  2PRE A;  4MZS A;  4WA6 A;  2AUZ A;  2YJC A;  1AEC A;  3KWZ A;  1STF E;  2DC7 A;  2FYE A;  1EWM A;  4G54 A;  4I04 A;  3QSD A;  4AXL A;  1KXR A;  3KWB X;  1S4V A;  4K7C A;  3USV A;  1BY8 A;  2XU3 A;  5JA7 A;  2DJG B;  3H89 A;  1PPP A;  2F1G A;  3M99 A;  2AVW A;  3N3G A;  2Y6E A;  3QJ3 A;  3K24 A;  4PI3 A;  3CH2 X;  3BOW A;  1X9Y A;  5K16 A;  1CSB B;  3IUT A;  4W5C A;  2ACT A;  2O6X A;  1VJV A;  2DCD A;  1EWO A;  1KFU L;  5CVM A;  4XUI A;  4RY2 A;  1GLO A;  2G8E A;  2AS8 A;  5JH3 A;  3MTN A;  2YJ2 A;  2R9C A;  3O1G A;  1AYW A;  2P86 A;  1YK8 A;  3RVX A;  4XR7 A;  3F5V A;  2G6D A;  2VHS A;  3MOR A;  1JQP A;  2P0R A;  3BPF A;  1YT7 A;  4Q8G A;  2H7J A;  3IEJ A;  2XU4 A;  1A6R A;  3BC3 A;  1TL9 A;  4QRX A;  3KKU A;  1PAD A;  1AYV A;  4I07 A;  1CQD A;  2HD5 A;  4CDF B;  1PE6 A;  2GFO A;  2IPP B;  2R9N A;  2C0Y A;  2AIM A;  3IMA A;  2VHF A;  1CB5 A;  2Y5B A;  2B1N A;  1EWP A;  1O0E A;  1KFX L;  2P7U A;  2R6N A;  3N3K A;  3IV2 A;  5CVN B;  1VSN A;  2FTD A;  1NQC A;  3S3Q A;  1YVB A;  3OVX A;  1NB3 A;  1PIP A;  3BWK A;  5J94 A;  1THE A;  2FQ9 A;  3MHH A;  1AU0 A;  3F75 A;  1F2B A;  9PAP A;  3QT4 A;  3LXS A;  1KHQ A;  1MHW A;  3PBH A;  1POP A;  3ERV A;  3LFY A;  6PAD A;  4YVA A;  1AU3 A;  3N4C A;  1PCI A;  4FJC A;  2NQG A;  1CJL A;  3ZUA A;  5EGW A;  4KLB A;  1GCB A;  2DC9 A;  3KFQ A;  2FUD A;  3PNR A;  5F02 A;  2OUL A;  3IHP A;  2WBF X;  2FO5 A;  1K3B B;  1QXP A;  3S3R A;  5FPW A;  4YYU A;  3E1Z B;  7PCK A;  4DMX A;  1BGO A;  3OF9 A;  1Y4H A;  4YYV A;  3RVW A;  1EWL A;  3I06 A;  1PBH A;  1NL6 A;  2DCA A;  1IWD A;  2XU5 A;  2B1M A;  3K9M A;  2DC8 A;  3PDF A;  1QDQ A;  3RVV A;  1U9V A;  3NHE A;  1MEG A;  1QMY A;  3V6C A;  3CBK A;  5CHT A;  1NLJ A;  4PP2 E;  4CDE B;  3TNX A;  2R9M A;  1F2A A;  3HHA A;  1ITO A;  1SP4 B;  1MDW A;  3P5W A;  4I05 A;  3H6S A;  1AU4 A;  1NB5 A;  1TLO A;  3H8C A;  2IBI A;  2YJB A;  1CPJ A;  3C9E A;  4N8W A;  4OEL A;  1PPD A;  2BDL A;  8PCH A;  3GCB A;  1CS8 A;  1YK7 A;  4P6E A;  4X6H A;  3WXF A;  2FRQ A;  3HWN A;  1PPN A;  1DF0 A;  4CDC B;  2FT2 A;  1U9W A;  1ME3 A;  3MHS A;  4X6I A;  4N4Z A;  2HXZ A;  1ICF A;  4YYQ A;  4BSQ A;  2AYO A;  3P5U A;  3HHI A;  3H8B A;  1CTE A;  2DZZ A;  2PNS A;  1MIR A;  2NQA A;  5PAD A;  3KW9 A;  1HUC B;  3OF8 A;  4CDD B;  4QBB A;  2F7D A;  2G8J A;  3P5X A;  1ME4 A;  1GMY A;  2R9F A;  4W4U A;  4BS5 A;  1BQI A;  1ZCM A;  2ATO A;  2NQD B;  2NQI A;  3OVZ A;  1CV8 A;  1M6D A;  4MZO A;  1CVZ A;  1MS6 A;  2DC6 A;  2GHU A;  2YJ8 A;  3HD3 A;  1U9X A;  2FRA A;  5A24 A;  4CZW A;  2JQF R;  1MEM A;  5CHV A;  2PAD A;  2HHN A;  1NPZ A;  4N79 A;  4BPV A;  1Q6K A;  2E01 A;  1XKG A;  3D6S A;  4DMY A;  4Q8H A;  3KSE A; 
#chains in the Genus database with same CATH topology
 3KX1 A;  3AI8 A;  2PBH A;  1GEC E;  3WXE A;  2CIO A;  2OP3 A;  4D8B A;  3B79 A;  1Y08 A;  4PAD A;  4X6J A;  2HH5 A;  2BDZ A;  3I3T A;  4PP1 A;  4OEM A;  3V6E A;  3BB7 A;  2AYN A;  3BCN A;  4QH6 A;  2OZ2 A;  4MSX A;  4FIP A;  4YV8 A;  2E00 A;  3U8E A;  1AU2 A;  4BS6 A;  4YYS A;  3ZNH A;  1ZIV A;  2ARY A;  2CB5 A;  2JQG R;  4BOQ A;  1KHP A;  1F2C A;  1F29 A;  4MI7 A;  3CBJ A;  4QRG A;  2E03 A;  1YAL A;  2AUX A;  2BTW A;  3K8U A;  4BOZ A;  4YYW A;  2XU1 A;  3P5V A;  2AU1 A;  3O0U A;  5CVO B;  1PPO A;  4AXM A;  2DCB A;  4BQV A;  3IOQ A;  3C0R A;  3H7D A;  2HWK A;  4FK5 A;  1EF7 A;  4MM3 B;  1U9Q X;  1PXV A;  2R9O A;  1ATK A;  3E9S A;  3WXG A;  1AYU A;  3CH3 X;  1DEU A;  1U5I A;  4W5B A;  1TU6 A;  4P6G A;  2DCC A;  1QOL A;  2E02 A;  4ZUX U;  4HWY A;  1BP4 A;  2G7Y A;  3OIS A;  2DZY A;  4QRV A;  4IUM A;  1SNK A;  1AIM A;  3BPM A;  4YYR A;  2YJ9 A;  2DJF B;  5EZQ A;  2JTC A;  5EF4 A;  3DF0 A;  3PW3 A;  1FH0 A;  2PRE A;  4MZS A;  4WA6 A;  4D8I A;  2AUZ A;  2YJC A;  4BOS A;  1AEC A;  3KWZ A;  1STF E;  2DC7 A;  2FYE A;  1EWM A;  4G54 A;  3PHU A;  4I04 A;  3QSD A;  4AXL A;  1KXR A;  3KWB X;  1S4V A;  4K7C A;  3USV A;  1BY8 A;  2XU3 A;  4GUA A;  5JA7 A;  2DJG B;  3H89 A;  1PPP A;  2F1G A;  3M99 A;  3MTV A;  2AVW A;  4P16 A;  2AGA A;  3N3G A;  5EZS A;  2Y6E A;  5E6J A;  3QJ3 A;  4REZ A;  3K24 A;  4PI3 A;  3CH2 X;  3BY4 A;  3BOW A;  1X9Y A;  5K16 A;  1CSB B;  3IUT A;  1PVJ A;  4W5C A;  2ACT A;  2O6X A;  1VJV A;  2DCD A;  1EWO A;  1KFU L;  5CVM A;  2BTW B;  4XUI A;  4RY2 A;  1GLO A;  2G8E A;  2AS8 A;  5JH3 A;  3MTN A;  2YJ2 A;  2R9C A;  3O1G A;  1AYW A;  2P86 A;  1YK8 A;  3RVX A;  4XR7 A;  3F5V A;  2G6D A;  3BBA A;  2VHS A;  3MOR A;  4OW0 A;  1JQP A;  2P0R A;  3BPF A;  1YT7 A;  4Q8G A;  2H7J A;  3IEJ A;  2XU4 A;  1A6R A;  3BC3 A;  1TL9 A;  4QRX A;  3KKU A;  3PRM A;  1PAD A;  1AYV A;  4I07 A;  4BOP A;  1CQD A;  2HD5 A;  4CDF B;  1PE6 A;  2GFO A;  2IPP B;  2R9N A;  2C0Y A;  2AIM A;  3IMA A;  2VHF A;  1DKI A;  1CB5 A;  2Y5B A;  2B1N A;  1EWP A;  1O0E A;  1KFX L;  2P7U A;  2R6N A;  3N3K A;  3IV2 A;  5CVN B;  1VSN A;  2FTD A;  1NQC A;  3S3Q A;  1YVB A;  3OVX A;  3RNV A;  1NB3 A;  1PIP A;  3BWK A;  5J94 A;  1THE A;  2FQ9 A;  3MHH A;  1AU0 A;  3F75 A;  1F2B A;  9PAP A;  3QT4 A;  3LXS A;  1KHQ A;  1MHW A;  3PBH A;  3W31 A;  3W30 A;  1POP A;  3ERV A;  3LFY A;  6PAD A;  4YVA A;  4WUR A;  4PT5 A;  1AU3 A;  3N4C A;  1PCI A;  4FJC A;  2NQG A;  4RKX A;  1CJL A;  4HXD B;  3ZUA A;  5EGW A;  4KLB A;  2DOS A;  1GCB A;  2DC9 A;  3KFQ A;  2FUD A;  3PNR A;  4RNA A;  5F02 A;  2OUL A;  3IHP A;  3IFU A;  2WBF X;  2FO5 A;  5JZE A;  1K3B B;  1QXP A;  3S3R A;  5FPW A;  4YYU A;  3E1Z B;  2BU3 A;  3TMP A;  7PCK A;  3PHW A;  3PSE A;  4DMX A;  1BGO A;  3OF9 A;  4XZX A;  1Y4H A;  4YYV A;  3RVW A;  1EWL A;  3I06 A;  1PBH A;  1NL6 A;  2DCA A;  1IWD A;  2XU5 A;  4M0W A;  4IP3 A;  2Z84 A;  2B1M A;  3K9M A;  2DC8 A;  3PDF A;  1QDQ A;  3RVV A;  2FE8 A;  4BOU A;  1U9V A;  3NHE A;  4OVZ A;  1MEG A;  1QMY A;  3V6C A;  3CBK A;  5CHT A;  1NLJ A;  3MJ5 A;  4PP2 E;  4CDE B;  3B21 A;  3TNX A;  2J7Q A;  2R9M A;  3PHX A;  1F2A A;  3HHA A;  3MP2 A;  2J7Q C;  1ITO A;  1SP4 B;  1MDW A;  5KO3 A;  3P5W A;  3H6S A;  4I05 A;  1AU4 A;  1NB5 A;  1TLO A;  4A5U A;  3H8C A;  2IBI A;  2YJB A;  1CPJ A;  3C9E A;  4N8W A;  4OEL A;  1PPD A;  2BDL A;  1YZB A;  8PCH A;  3GCB A;  1CS8 A;  1YK7 A;  4P6E A;  4X6H A;  3WXF A;  2FRQ A;  3HWN A;  1PPN A;  1DF0 A;  4CDC B;  2FT2 A;  1U9W A;  1ME3 A;  3PT2 A;  3MHS A;  4X6I A;  4N4Z A;  2HXZ A;  1ICF A;  4YYQ A;  1UKF A;  4BSQ A;  4R3D A;  2UZJ A;  2AYO A;  3P5U A;  3HHI A;  3H8B A;  4ZTB A;  1CTE A;  2DZZ A;  2PNS A;  1MIR A;  2NQA A;  2JRI A;  5PAD A;  4RF1 A;  3KW9 A;  1HUC B;  3OF8 A;  4CDD B;  4QBB A;  2F7D A;  2G8J A;  3P5X A;  1ME4 A;  1GMY A;  2R9F A;  4W4U A;  4BS5 A;  1BQI A;  1ZCM A;  3OQC A;  2ATO A;  2NQD B;  2NQI A;  4D8E A;  3OVZ A;  1CV8 A;  3PRP A;  1M6D A;  4MZO A;  1CVZ A;  1MS6 A;  2DC6 A;  2GHU A;  2YJ8 A;  3HD3 A;  1U9X A;  3O65 A;  2FRA A;  5A24 A;  4OVZ B;  4CZW A;  2JQF R;  1MEM A;  4RF0 A;  5CHV A;  2PAD A;  2HHN A;  1NPZ A;  4N79 A;  4BPV A;  1Q6K A;  2E01 A;  1XKG A;  3D6S A;  4DMY A;  4Q8H A;  3KSE A;  3TRK A; 
#chains in the Genus database with same CATH homology
 3KX1 A;  3AI8 A;  2PBH A;  1GEC E;  3WXE A;  2CIO A;  2OP3 A;  3B79 A;  1Y08 A;  4PAD A;  4X6J A;  2HH5 A;  2BDZ A;  3I3T A;  4PP1 A;  4OEM A;  3V6E A;  2AYN A;  3BCN A;  4QH6 A;  2OZ2 A;  4MSX A;  4FIP A;  4YV8 A;  2E00 A;  3U8E A;  1AU2 A;  4BS6 A;  4YYS A;  1ZIV A;  2ARY A;  2CB5 A;  2JQG R;  1KHP A;  1W5R A;  1F2C A;  1F29 A;  3CBJ A;  4QRG A;  2E03 A;  1YAL A;  2AUX A;  4YYW A;  3K8U A;  2XU1 A;  3P5V A;  2AU1 A;  3O0U A;  5CVO B;  3D9W A;  1PPO A;  4AXM A;  2DCB A;  4BQV A;  3IOQ A;  3H7D A;  4FK5 A;  1EF7 A;  1U9Q X;  1PXV A;  2R9O A;  1W4T A;  1ATK A;  3WXG A;  1AYU A;  3CH3 X;  1DEU A;  1U5I A;  4W5B A;  1TU6 A;  4P6G A;  2DCC A;  1QOL A;  2E02 A;  4ZUX U;  4HWY A;  1BP4 A;  2G7Y A;  3OIS A;  2DZY A;  4QRV A;  1SNK A;  1AIM A;  3BPM A;  4YYR A;  2YJ9 A;  2DJF B;  5EF4 A;  3DF0 A;  3PW3 A;  1FH0 A;  2PRE A;  4MZS A;  4WA6 A;  2AUZ A;  2YJC A;  1AEC A;  3KWZ A;  1STF E;  2DC7 A;  2FYE A;  1EWM A;  4G54 A;  4I04 A;  3QSD A;  4AXL A;  1KXR A;  3KWB X;  1S4V A;  4K7C A;  3USV A;  1BY8 A;  2XU3 A;  5JA7 A;  2DJG B;  3H89 A;  1PPP A;  2F1G A;  3M99 A;  2AVW A;  3N3G A;  2Y6E A;  3QJ3 A;  3K24 A;  4PI3 A;  3CH2 X;  3BOW A;  1X9Y A;  5K16 A;  1CSB B;  3IUT A;  4W5C A;  2ACT A;  2O6X A;  1VJV A;  2DCD A;  1EWO A;  1KFU L;  5CVM A;  4XUI A;  4RY2 A;  1GLO A;  2G8E A;  2AS8 A;  5JH3 A;  3MTN A;  2YJ2 A;  2R9C A;  3O1G A;  1AYW A;  2P86 A;  1YK8 A;  3RVX A;  4XR7 A;  3F5V A;  2G6D A;  2VHS A;  3MOR A;  1JQP A;  2P0R A;  3BPF A;  1YT7 A;  4Q8G A;  2H7J A;  2VFB A;  3IEJ A;  2XU4 A;  1A6R A;  3BC3 A;  1TL9 A;  4QRX A;  3KKU A;  1PAD A;  1AYV A;  4I07 A;  1CQD A;  2HD5 A;  4CDF B;  1PE6 A;  2GFO A;  2IPP B;  2R9N A;  2C0Y A;  2AIM A;  3IMA A;  1W6F A;  2VHF A;  1CB5 A;  2Y5B A;  2B1N A;  1EWP A;  1O0E A;  2VFC A;  1KFX L;  4NV7 A;  2P7U A;  2R6N A;  3N3K A;  3IV2 A;  5CVN B;  1VSN A;  2FTD A;  1NQC A;  3S3Q A;  1YVB A;  3OVX A;  1NB3 A;  1PIP A;  3BWK A;  5J94 A;  3LTW A;  1THE A;  2FQ9 A;  3MHH A;  1AU0 A;  3F75 A;  1F2B A;  9PAP A;  3QT4 A;  3LXS A;  1KHQ A;  1MHW A;  3PBH A;  1POP A;  3ERV A;  3LFY A;  6PAD A;  4YVA A;  1AU3 A;  3N4C A;  1PCI A;  4FJC A;  2NQG A;  1CJL A;  3ZUA A;  5EGW A;  4KLB A;  1GCB A;  2DC9 A;  3KFQ A;  2FUD A;  3PNR A;  5F02 A;  2OUL A;  3IHP A;  4BGF A;  1GX3 A;  2WBF X;  2FO5 A;  1K3B B;  1QXP A;  3S3R A;  5FPW A;  4YYU A;  3E1Z B;  7PCK A;  4DMX A;  4C5P A;  1BGO A;  3OF9 A;  1Y4H A;  4YYV A;  3RVW A;  1EWL A;  3I06 A;  1PBH A;  1NL6 A;  2DCA A;  1IWD A;  2XU5 A;  2B1M A;  3K9M A;  2DC8 A;  3PDF A;  1QDQ A;  3RVV A;  1U9V A;  3NHE A;  1MEG A;  1QMY A;  3V6C A;  3CBK A;  5CHT A;  1NLJ A;  4PP2 E;  4CDE B;  3TNX A;  2R9M A;  1F2A A;  3HHA A;  1ITO A;  1SP4 B;  1MDW A;  3P5W A;  4I05 A;  3H6S A;  1AU4 A;  1NB5 A;  1TLO A;  2BSZ A;  3H8C A;  2IBI A;  2YJB A;  1CPJ A;  3C9E A;  4N8W A;  4OEL A;  1PPD A;  2BDL A;  8PCH A;  3GCB A;  1CS8 A;  1YK7 A;  4P6E A;  4X6H A;  3WXF A;  2FRQ A;  3HWN A;  1PPN A;  1DF0 A;  4CDC B;  2FT2 A;  1U9W A;  1ME3 A;  3MHS A;  4X6I A;  4N4Z A;  2HXZ A;  1ICF A;  4YYQ A;  4BSQ A;  2AYO A;  3P5U A;  3HHI A;  3H8B A;  1CTE A;  4B55 A;  1E2T A;  2DZZ A;  2PNS A;  1MIR A;  2NQA A;  5PAD A;  3KW9 A;  1HUC B;  3OF8 A;  4CDD B;  4QBB A;  2F7D A;  2G8J A;  3P5X A;  1ME4 A;  1GMY A;  2R9F A;  4W4U A;  4BS5 A;  1BQI A;  1ZCM A;  2ATO A;  2NQD B;  2NQI A;  3OVZ A;  1CV8 A;  1M6D A;  4MZO A;  1CVZ A;  1MS6 A;  2DC6 A;  2GHU A;  2YJ8 A;  3HD3 A;  1U9X A;  2FRA A;  5A24 A;  4CZW A;  2JQF R;  1MEM A;  4GUZ A;  4NV8 A;  5CHV A;  2PAD A;  2HHN A;  1NPZ A;  4N79 A;  4BPV A;  1Q6K A;  2E01 A;  1XKG A;  3D6S A;  4DMY A;  4Q8H A;  3KSE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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