4P6GA

Crystal structure of human cathepsin s bound to a non-covalent inhibitor.
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
219
structure length
219
Chain Sequence
ILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEIE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Cathepsin S
total genus 70
structure length 219
sequence length 219
chains with identical sequence B, C, D
ec nomenclature ec 3.4.22.27: Cathepsin S.
pdb deposition date 2014-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4p6gA00
1PADA 2NQGA 2DZZA 4QRXA 1F29A 2HHNA 1AU2A 2P7UA 3S3QA 1X9YA 4YYRA 1Y08A 1F2AA 1CS8A 3MHHA 4YYSA 3HD3A 1NB3A 5JH3A 1MEGA 1MIRA 2Y6EA 3IMAA 2XU5A 1CQDA 1GCBA 1AYVA 1ME4A 2DCDA 3IV2A 5K16A 3QSDA 3H89A 4Q8GA 3TNXA 2YJCA 2H7JA 1NQCA 2Y5BA 4BPVA 1POPA 4OELA 2HXZA 2R9MA 4HWYA 4OEMA 1PPPA 4KLBA 2AU1A 3PNRA 5EF4A 2CIOA 4DMXA 2G8EA 1MHWA 1CJLA 3KWBX 2DC8A 2G6DA 3C9EA 1KFUL 2PREA 2FYEA 3I06A 1EWLA 1M6DA 4I04A 3HHIA 2E00A 1MS6A 1F2CA 4N79A 4YYVA 1DEUA 1DF0A 3O1GA 9PAPA 3RVWA 5CHTA 1CPJA 3P5UA 4X6IA 2OULA 2YJ9A 1CSBB 1U9QX 2DCCA 3N4CA 4CDCB 4MZOA 2DC7A 1PPOA 3QJ3A 1NLJA 3KKUA 1U9VA 1O0EA 2CB5A 1PBHA 2ARYA 5F02A 2P86A 4YVAA 2F7DA 1YVBA 3MHSA 3H7DA 1Q6KA 2FO5A 4G54A 2AUXA 3K9MA 3USVA 3KSEA 3E1ZB 1PXVA 3QT4A 1XKGA 1U9WA 3AI8A 1AYWA 2P0RA 3M99A 4QBBA 1ZCMA 3P5WA 3ZUAA 1BGOA 2DZYA 3KWZA 4YV8A 3H8BA 1QXPA 3BC3A 3H6SA 1AU0A 1CB5A 2BDLA 3KFQA 3BPFA 2DC6A 1STFE 1QDQA 1MDWA 4BS5A 1ATKA 4PP1A 4P6GA 3F75A 2B1MA 2IPPB 2FRAA 3D6SA 2GHUA 3OVZA 1EWMA 4ZUXU 4BQVA 2NQDB 1BQIA 4YYWA 1SNKA 5CVMA 2AUZA 2E03A 2E02A 1U9XA 4BSQA 2XU4A 1YALA 3WXEA 4FK5A 2GFOA 4BS6A 3BWKA 1AYUA 5CHVA 2O6XA 1YT7A 4PP2E 3MTNA 3P5XA 3F5VA 2FUDA 1VSNA 2B1NA 3OVXA 6PADA 2WBFX 3GCBA 1AECA 5J94A 4Q8HA 3OF9A 3CH2X 2G8JA 8PCHA 4DMYA 2E01A 4AXMA 2YJBA 3K8UA 3CH3X 2AYOA 1BP4A 3IOQA 4W5CA 2DCBA 3CBKA 1KFXL 4QH6A 4X6HA 1PE6A 2JQGR 4CDDB 3WXGA 4MSXA 1VJVA 4N4ZA 3WXFA 1TU6A 3ERVA 2HD5A 1K3BB 2ACTA 3B79A 3OISA 1AIMA 3P5VA 4QRVA 2XU3A 1EWOA 3KW9A 4CZWA 4PADA 2BDZA 2VHSA 2YJ8A 4XUIA 3RVVA 4YYQA 2FQ9A 4MZSA 3N3KA 1GLOA 1HUCB 1QMYA 4PI3A 1NPZA 4W4UA 4WA6A 4FIPA 4K7CA 3IUTA 2AS8A 4RY2A 3IHPA 4XR7A 1ICFA 2DCAA 3K24A 3PBHA 2OP3A 3O0UA 1NL6A 1KXRA 1F2BA 1PIPA 3NHEA 5JA7A 3DF0A 4P6EA 2R9FA 1KHQA 1PCIA 2PNSA 3U8EA 1CVZA 2XU1A 3V6EA 3KX1A 2DJFB 2VHFA 2NQIA 1S4VA 2YJ2A 1AU3A 2HH5A 2R9CA 1EWPA 2IBIA 1YK8A 3IEJA 1GMYA 3S3RA 3RVXA 7PCKA 2AIMA 1Y4HA 4W5BA 2DC9A 1ZIVA 3HHAA 2PBHA 5EGWA 4CDEB 2DJGB 3HWNA 1CV8A 2R9NA 3N3GA 2FRQA 1A6RA 2PADA 3BOWA 3BPMA 3OF8A 5A24A 4I07A 3CBJA 4CDFB 3LFYA 5FPWA 2C0YA 1MEMA 1PPDA 3PDFA 3LXSA 4X6JA 2OZ2A 1U5IA 1EF7A 3V6CA 1YK7A 3PW3A 1THEA 1BY8A 3BCNA 4YYUA 2F1GA 4FJCA 3MORA 1ME3A 5CVNB 1ITOA 1GECE 1TL9A 2ATOA 2NQAA 2AYNA 2R9OA 1PPNA 2R6NA 1KHPA 1QOLA 5CVOB 1IWDA 1TLOA 1JQPA 4QRGA 4I05A 1AU4A 4N8WA 2AVWA 1SP4B 2FTDA 2FT2A 4AXLA 3I3TA 1CTEA 2G7YA 3H8CA 1NB5A 2JQFR 1FH0A 5PADA
chains in the Genus database with same CATH superfamily
1PADA 2NQGA 2DZZA 4QRXA 1F29A 2HHNA 4OVZA 1AU2A 2P7UA 3S3QA 1X9YA 4RNAA 4YYRA 1Y08A 4MM3B 1F2AA 1CS8A 3MHHA 4YYSA 3HD3A 1NB3A 5JH3A 4BOSA 1MEGA 1MIRA 2Y6EA 3IMAA 2XU5A 4WURA 1CQDA 1GCBA 1AYVA 1ME4A 2DCDA 3IV2A 5K16A 3QSDA 3H89A 4Q8GA 3TNXA 2YJCA 2H7JA 1NQCA 4REZA 2Y5BA 2J7QC 4BPVA 1POPA 4OELA 2HXZA 2R9MA 4HWYA 4OEMA 1PPPA 4KLBA 2AU1A 3PNRA 4HXDB 5EF4A 2CIOA 4DMXA 2G8EA 1MHWA 3IFUA 1CJLA 3KWBX 2DC8A 4IP3A 2G6DA 3C9EA 3PT2A 4ZTBA 1KFUL 2PREA 2FYEA 3I06A 1EWLA 1M6DA 4I04A 3PHXA 3HHIA 2E00A 1MS6A 1F2CA 4N79A 4YYVA 1DEUA 1DF0A 3O1GA 1YZBA 9PAPA 3RVWA 5CHTA 1CPJA 2FE8A 4D8BA 3P5UA 4X6IA 2OULA 2YJ9A 1CSBB 1U9QX 2DCCA 3N4CA 4CDCB 4MZOA 2DC7A 1PPOA 1PVJA 3QJ3A 1NLJA 3KKUA 1U9VA 1O0EA 2CB5A 1PBHA 2ARYA 5F02A 2P86A 4YVAA 2F7DA 1YVBA 3MHSA 3H7DA 1Q6KA 2FO5A 4G54A 2AUXA 3K9MA 3USVA 3KSEA 3E1ZB 1PXVA 3QT4A 1XKGA 1U9WA 3AI8A 5JZEA 1AYWA 2P0RA 3PRMA 3M99A 4QBBA 1ZCMA 3P5WA 3ZUAA 1BGOA 2DZYA 3KWZA 4YV8A 3PHUA 3H8BA 2HWKA 2BU3A 1QXPA 3BC3A 3H6SA 5KO3A 1UKFA 1AU0A 1CB5A 2BDLA 3KFQA 3BPFA 2DC6A 1STFE 1QDQA 1MDWA 4BS5A 4BOQA 3TMPA 1ATKA 4PP1A 4P6GA 3F75A 2B1MA 2IPPB 2FRAA 3D6SA 2GHUA 5E6JA 3OVZA 1EWMA 3PHWA 4XZXA 4BQVA 4ZUXU 2NQDB 1BQIA 4YYWA 1SNKA 5CVMA 3ZNHA 2JRIA 2AUZA 2E03A 2E02A 1U9XA 4BSQA 2XU4A 1YALA 3WXEA 4FK5A 2GFOA 4BS6A 3BWKA 1AYUA 5CHVA 4BOUA 4PT5A 2O6XA 1YT7A 4R3DA 4PP2E 3MTNA 3P5XA 3F5VA 2FUDA 4GUAA 1VSNA 2B1NA 3BB7A 3OVXA 4RF1A 6PADA 2WBFX 3MP2A 4OW0A 3GCBA 1AECA 5J94A 4Q8HA 3OF9A 3CH2X 2G8JA 8PCHA 4DMYA 2E01A 4AXMA 2YJBA 3K8UA 3CH3X 2AYOA 2DOSA 1BP4A 3IOQA 4W5CA 2DCBA 3TRKA 3CBKA 1KFXL 4QH6A 4D8EA 4X6HA 1PE6A 2JQGR 5EZQA 3WXGA 4CDDB 4MSXA 1VJVA 4N4ZA 3WXFA 1TU6A 4RF0A 3ERVA 2HD5A 1K3BB 2ACTA 3B79A 3OISA 1AIMA 3P5VA 4QRVA 2XU3A 1EWOA 3KW9A 3OQCA 4CZWA 4OVZB 4PADA 2BDZA 2VHSA 2YJ8A 4XUIA 5EZSA 3RVVA 4YYQA 2FQ9A 4MZSA 3N3KA 1GLOA 1HUCB 1QMYA 4PI3A 1NPZA 4W4UA 4WA6A 4A5UA 3B21A 4FIPA 4K7CA 3IUTA 2AS8A 4RY2A 3IHPA 4XR7A 1ICFA 2DCAA 3K24A 3PBHA 2OP3A 3O0UA 1NL6A 1KXRA 1F2BA 1PIPA 3BY4A 3NHEA 5JA7A 3DF0A 4P6EA 2R9FA 1KHQA 1PCIA 2PNSA 3U8EA 1CVZA 2XU1A 3V6EA 3KX1A 3O65A 2DJFB 4BOZA 3C0RA 2VHFA 2NQIA 4MI7A 3MJ5A 1S4VA 2YJ2A 1AU3A 2HH5A 2R9CA 1EWPA 2IBIA 1YK8A 3IEJA 1GMYA 2BTWB 3S3RA 3MTVA 3RVXA 7PCKA 2AIMA 4IUMA 1Y4HA 4W5BA 2DC9A 1ZIVA 3HHAA 2PBHA 5EGWA 4CDEB 2UZJA 3BBAA 2DJGB 3HWNA 1CV8A 3RNVA 2R9NA 3N3GA 2FRQA 4BOPA 1A6RA 2PADA 3BOWA 3BPMA 3OF8A 5A24A 4I07A 3CBJA 4CDFB 2Z84A 3LFYA 5FPWA 3PSEA 4D8IA 2C0YA 2BTWA 1MEMA 1PPDA 4M0WA 3PDFA 2J7QA 3LXSA 2OZ2A 4X6JA 1U5IA 1EF7A 3V6CA 2JTCA 1YK7A 3PW3A 1THEA 3W31A 1BY8A 3BCNA 3PRPA 4YYUA 2F1GA 4FJCA 4P16A 3MORA 1ME3A 5CVNB 1DKIA 1ITOA 2AGAA 3W30A 1GECE 1TL9A 4RKXA 2ATOA 2NQAA 2AYNA 2R9OA 1PPNA 2R6NA 1KHPA 1QOLA 5CVOB 1IWDA 1TLOA 1JQPA 4QRGA 4I05A 1AU4A 3E9SA 4N8WA 2AVWA 1SP4B 2FTDA 2FT2A 4AXLA 3I3TA 1CTEA 2G7YA 3H8CA 1NB5A 2JQFR 1FH0A 5PADA
chains in the Genus database with same CATH topology
1PADA 2NQGA 2DZZA 4QRXA 1F29A 2HHNA 1AU2A 2P7UA 3S3QA 1X9YA 4YYRA 1Y08A 1F2AA 1CS8A 3MHHA 4YYSA 3HD3A 1NB3A 5JH3A 1MEGA 1MIRA 2Y6EA 3IMAA 2XU5A 1CQDA 1GCBA 1AYVA 1ME4A 2DCDA 3IV2A 5K16A 3QSDA 3H89A 4Q8GA 3TNXA 2YJCA 2H7JA 1NQCA 2Y5BA 2BSZA 4BPVA 1POPA 4OELA 2HXZA 2R9MA 4HWYA 4OEMA 1PPPA 4KLBA 1W6FA 2AU1A 3PNRA 5EF4A 2CIOA 4DMXA 2G8EA 1MHWA 1CJLA 3KWBX 2DC8A 2G6DA 4B55A 3C9EA 1KFUL 4NV7A 2PREA 2FYEA 3I06A 1EWLA 4BGFA 1M6DA 4I04A 3HHIA 2E00A 1MS6A 1F2CA 4N79A 4YYVA 1DEUA 1DF0A 3O1GA 9PAPA 3RVWA 5CHTA 1CPJA 3P5UA 4X6IA 2OULA 2YJ9A 1CSBB 1U9QX 2DCCA 3N4CA 4CDCB 4MZOA 2DC7A 1PPOA 3QJ3A 1NLJA 3KKUA 1U9VA 1O0EA 2CB5A 1PBHA 2ARYA 5F02A 2P86A 4YVAA 2F7DA 1YVBA 3MHSA 3H7DA 1Q6KA 2FO5A 4C5PA 4G54A 2AUXA 3K9MA 3USVA 3KSEA 3E1ZB 2VFBA 1PXVA 3QT4A 1XKGA 1U9WA 3AI8A 1AYWA 2P0RA 3M99A 4QBBA 1ZCMA 4NV8A 3P5WA 3ZUAA 1BGOA 2DZYA 3KWZA 4YV8A 3H8BA 1QXPA 3BC3A 3H6SA 1AU0A 1CB5A 2BDLA 3KFQA 3BPFA 2DC6A 1STFE 1QDQA 1MDWA 4BS5A 1ATKA 4PP1A 4P6GA 3F75A 2B1MA 2IPPB 2FRAA 3D6SA 2GHUA 3LTWA 3OVZA 1EWMA 4ZUXU 4BQVA 2NQDB 1BQIA 4YYWA 1SNKA 5CVMA 2AUZA 2E03A 2E02A 1U9XA 4BSQA 2XU4A 1YALA 3WXEA 4FK5A 2GFOA 4BS6A 3BWKA 1AYUA 5CHVA 3D9WA 2O6XA 1YT7A 4PP2E 3MTNA 3P5XA 3F5VA 2FUDA 1VSNA 2B1NA 3OVXA 6PADA 2WBFX 3GCBA 1AECA 5J94A 4Q8HA 3OF9A 3CH2X 2G8JA 8PCHA 4DMYA 2E01A 4AXMA 2YJBA 3K8UA 3CH3X 2AYOA 1BP4A 3IOQA 4W5CA 2DCBA 3CBKA 1KFXL 4QH6A 4X6HA 1PE6A 4GUZA 2JQGR 4CDDB 3WXGA 4MSXA 1VJVA 4N4ZA 3WXFA 1TU6A 3ERVA 2HD5A 1K3BB 2ACTA 3B79A 3OISA 1W4TA 1AIMA 3P5VA 4QRVA 2VFCA 2XU3A 1EWOA 3KW9A 4CZWA 4PADA 2BDZA 2VHSA 2YJ8A 4XUIA 3RVVA 4YYQA 2FQ9A 4MZSA 3N3KA 1GLOA 1HUCB 1QMYA 4PI3A 1NPZA 4W4UA 4WA6A 4FIPA 4K7CA 3IUTA 2AS8A 4RY2A 3IHPA 4XR7A 1ICFA 2DCAA 3K24A 3PBHA 2OP3A 3O0UA 1NL6A 1KXRA 1F2BA 1PIPA 3NHEA 5JA7A 3DF0A 4P6EA 2R9FA 1KHQA 1PCIA 2PNSA 3U8EA 1CVZA 2XU1A 3V6EA 3KX1A 2DJFB 2VHFA 2NQIA 1S4VA 2YJ2A 1AU3A 2HH5A 2R9CA 1EWPA 2IBIA 1YK8A 3IEJA 1GMYA 3S3RA 3RVXA 7PCKA 2AIMA 1Y4HA 4W5BA 2DC9A 1ZIVA 3HHAA 2PBHA 5EGWA 4CDEB 2DJGB 3HWNA 1CV8A 2R9NA 3N3GA 2FRQA 1E2TA 1A6RA 2PADA 3BOWA 3BPMA 3OF8A 5A24A 4I07A 3CBJA 4CDFB 3LFYA 5FPWA 1W5RA 2C0YA 1MEMA 1PPDA 3PDFA 3LXSA 4X6JA 2OZ2A 1U5IA 1EF7A 3V6CA 1YK7A 3PW3A 1THEA 1BY8A 3BCNA 4YYUA 2F1GA 4FJCA 3MORA 1ME3A 5CVNB 1ITOA 1GECE 1TL9A 2ATOA 2NQAA 2AYNA 2R9OA 1PPNA 2R6NA 1KHPA 1QOLA 5CVOB 1IWDA 1TLOA 1JQPA 4QRGA 4I05A 1AU4A 4N8WA 2AVWA 1SP4B 2FTDA 2FT2A 4AXLA 3I3TA 1CTEA 2G7YA 3H8CA 1NB5A 1GX3A 2JQFR 1FH0A 5PADA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PAD A;  2NQG A;  2DZZ A;  4QRX A;  1F29 A;  2HHN A;  1AU2 A;  2P7U A;  3S3Q A;  1X9Y A;  4YYR A;  1Y08 A;  1F2A A;  1CS8 A;  3MHH A;  4YYS A;  3HD3 A;  1NB3 A;  5JH3 A;  1MEG A;  1MIR A;  2Y6E A;  3IMA A;  2XU5 A;  1CQD A;  1GCB A;  1AYV A;  1ME4 A;  2DCD A;  3IV2 A;  5K16 A;  3QSD A;  3H89 A;  4Q8G A;  3TNX A;  2YJC A;  2H7J A;  1NQC A;  2Y5B A;  4BPV A;  1POP A;  4OEL A;  2HXZ A;  2R9M A;  4HWY A;  4OEM A;  1PPP A;  4KLB A;  2AU1 A;  3PNR A;  5EF4 A;  2CIO A;  4DMX A;  2G8E A;  1MHW A;  1CJL A;  3KWB X;  2DC8 A;  2G6D A;  3C9E A;  1KFU L;  2PRE A;  2FYE A;  3I06 A;  1EWL A;  1M6D A;  4I04 A;  3HHI A;  2E00 A;  1MS6 A;  1F2C A;  4N79 A;  4YYV A;  1DEU A;  1DF0 A;  3O1G A;  9PAP A;  3RVW A;  5CHT A;  1CPJ A;  3P5U A;  4X6I A;  2OUL A;  2YJ9 A;  1CSB B;  1U9Q X;  2DCC A;  3N4C A;  4CDC B;  4MZO A;  2DC7 A;  1PPO A;  3QJ3 A;  1NLJ A;  3KKU A;  1U9V A;  1O0E A;  2CB5 A;  1PBH A;  2ARY A;  5F02 A;  2P86 A;  4YVA A;  2F7D A;  1YVB A;  3MHS A;  3H7D A;  1Q6K A;  2FO5 A;  4G54 A;  2AUX A;  3K9M A;  3USV A;  3KSE A;  3E1Z B;  1PXV A;  3QT4 A;  1XKG A;  1U9W A;  3AI8 A;  1AYW A;  2P0R A;  3M99 A;  4QBB A;  1ZCM A;  3P5W A;  3ZUA A;  1BGO A;  2DZY A;  3KWZ A;  4YV8 A;  3H8B A;  1QXP A;  3BC3 A;  3H6S A;  1AU0 A;  1CB5 A;  2BDL A;  3KFQ A;  3BPF A;  2DC6 A;  1STF E;  1QDQ A;  1MDW A;  4BS5 A;  1ATK A;  4PP1 A;  4P6G A;  3F75 A;  2B1M A;  2IPP B;  2FRA A;  3D6S A;  2GHU A;  3OVZ A;  1EWM A;  4ZUX U;  4BQV A;  2NQD B;  1BQI A;  4YYW A;  1SNK A;  5CVM A;  2AUZ A;  2E03 A;  2E02 A;  1U9X A;  4BSQ A;  2XU4 A;  1YAL A;  3WXE A;  4FK5 A;  2GFO A;  4BS6 A;  3BWK A;  1AYU A;  5CHV A;  2O6X A;  1YT7 A;  4PP2 E;  3MTN A;  3P5X A;  3F5V A;  2FUD A;  1VSN A;  2B1N A;  3OVX A;  6PAD A;  2WBF X;  3GCB A;  1AEC A;  5J94 A;  4Q8H A;  3OF9 A;  3CH2 X;  2G8J A;  8PCH A;  4DMY A;  2E01 A;  4AXM A;  2YJB A;  3K8U A;  3CH3 X;  2AYO A;  1BP4 A;  3IOQ A;  4W5C A;  2DCB A;  3CBK A;  1KFX L;  4QH6 A;  4X6H A;  1PE6 A;  2JQG R;  4CDD B;  3WXG A;  4MSX A;  1VJV A;  4N4Z A;  3WXF A;  1TU6 A;  3ERV A;  2HD5 A;  1K3B B;  2ACT A;  3B79 A;  3OIS A;  1AIM A;  3P5V A;  4QRV A;  2XU3 A;  1EWO A;  3KW9 A;  4CZW A;  4PAD A;  2BDZ A;  2VHS A;  2YJ8 A;  4XUI A;  3RVV A;  4YYQ A;  2FQ9 A;  4MZS A;  3N3K A;  1GLO A;  1HUC B;  1QMY A;  4PI3 A;  1NPZ A;  4W4U A;  4WA6 A;  4FIP A;  4K7C A;  3IUT A;  2AS8 A;  4RY2 A;  3IHP A;  4XR7 A;  1ICF A;  2DCA A;  3K24 A;  3PBH A;  2OP3 A;  3O0U A;  1NL6 A;  1KXR A;  1F2B A;  1PIP A;  3NHE A;  5JA7 A;  3DF0 A;  4P6E A;  2R9F A;  1KHQ A;  1PCI A;  2PNS A;  3U8E A;  1CVZ A;  2XU1 A;  3V6E A;  3KX1 A;  2DJF B;  2VHF A;  2NQI A;  1S4V A;  2YJ2 A;  1AU3 A;  2HH5 A;  2R9C A;  1EWP A;  2IBI A;  1YK8 A;  3IEJ A;  1GMY A;  3S3R A;  3RVX A;  7PCK A;  2AIM A;  1Y4H A;  4W5B A;  2DC9 A;  1ZIV A;  3HHA A;  2PBH A;  5EGW A;  4CDE B;  2DJG B;  3HWN A;  1CV8 A;  2R9N A;  3N3G A;  2FRQ A;  1A6R A;  2PAD A;  3BOW A;  3BPM A;  3OF8 A;  5A24 A;  4I07 A;  3CBJ A;  4CDF B;  3LFY A;  5FPW A;  2C0Y A;  1MEM A;  1PPD A;  3PDF A;  3LXS A;  4X6J A;  2OZ2 A;  1U5I A;  1EF7 A;  3V6C A;  1YK7 A;  3PW3 A;  1THE A;  1BY8 A;  3BCN A;  4YYU A;  2F1G A;  4FJC A;  3MOR A;  1ME3 A;  5CVN B;  1ITO A;  1GEC E;  1TL9 A;  2ATO A;  2NQA A;  2AYN A;  2R9O A;  1PPN A;  2R6N A;  1KHP A;  1QOL A;  5CVO B;  1IWD A;  1TLO A;  1JQP A;  4QRG A;  4I05 A;  1AU4 A;  4N8W A;  2AVW A;  1SP4 B;  2FTD A;  2FT2 A;  4AXL A;  3I3T A;  1CTE A;  2G7Y A;  3H8C A;  1NB5 A;  2JQF R;  1FH0 A;  5PAD A; 
#chains in the Genus database with same CATH topology
 1PAD A;  2NQG A;  2DZZ A;  4QRX A;  1F29 A;  2HHN A;  4OVZ A;  1AU2 A;  2P7U A;  3S3Q A;  1X9Y A;  4RNA A;  4YYR A;  1Y08 A;  4MM3 B;  1F2A A;  1CS8 A;  3MHH A;  4YYS A;  3HD3 A;  1NB3 A;  5JH3 A;  4BOS A;  1MEG A;  1MIR A;  2Y6E A;  3IMA A;  2XU5 A;  4WUR A;  1CQD A;  1GCB A;  1AYV A;  1ME4 A;  2DCD A;  3IV2 A;  5K16 A;  3QSD A;  3H89 A;  4Q8G A;  3TNX A;  2YJC A;  2H7J A;  1NQC A;  4REZ A;  2Y5B A;  2J7Q C;  4BPV A;  1POP A;  4OEL A;  2HXZ A;  2R9M A;  4HWY A;  4OEM A;  1PPP A;  4KLB A;  2AU1 A;  3PNR A;  4HXD B;  5EF4 A;  2CIO A;  4DMX A;  2G8E A;  1MHW A;  3IFU A;  1CJL A;  3KWB X;  2DC8 A;  4IP3 A;  2G6D A;  3C9E A;  3PT2 A;  4ZTB A;  1KFU L;  2PRE A;  2FYE A;  3I06 A;  1EWL A;  1M6D A;  4I04 A;  3PHX A;  3HHI A;  2E00 A;  1MS6 A;  1F2C A;  4N79 A;  4YYV A;  1DEU A;  1DF0 A;  3O1G A;  1YZB A;  9PAP A;  3RVW A;  5CHT A;  1CPJ A;  2FE8 A;  4D8B A;  3P5U A;  4X6I A;  2OUL A;  2YJ9 A;  1CSB B;  1U9Q X;  2DCC A;  3N4C A;  4CDC B;  4MZO A;  2DC7 A;  1PPO A;  1PVJ A;  3QJ3 A;  1NLJ A;  3KKU A;  1U9V A;  1O0E A;  2CB5 A;  1PBH A;  2ARY A;  5F02 A;  2P86 A;  4YVA A;  2F7D A;  1YVB A;  3MHS A;  3H7D A;  1Q6K A;  2FO5 A;  4G54 A;  2AUX A;  3K9M A;  3USV A;  3KSE A;  3E1Z B;  1PXV A;  3QT4 A;  1XKG A;  1U9W A;  3AI8 A;  5JZE A;  1AYW A;  2P0R A;  3PRM A;  3M99 A;  4QBB A;  1ZCM A;  3P5W A;  3ZUA A;  1BGO A;  2DZY A;  3KWZ A;  4YV8 A;  3PHU A;  3H8B A;  2HWK A;  2BU3 A;  1QXP A;  3BC3 A;  3H6S A;  5KO3 A;  1UKF A;  1AU0 A;  1CB5 A;  2BDL A;  3KFQ A;  3BPF A;  2DC6 A;  1STF E;  1QDQ A;  1MDW A;  4BS5 A;  4BOQ A;  3TMP A;  1ATK A;  4PP1 A;  4P6G A;  3F75 A;  2B1M A;  2IPP B;  2FRA A;  3D6S A;  2GHU A;  5E6J A;  3OVZ A;  1EWM A;  3PHW A;  4XZX A;  4BQV A;  4ZUX U;  2NQD B;  1BQI A;  4YYW A;  1SNK A;  5CVM A;  3ZNH A;  2JRI A;  2AUZ A;  2E03 A;  2E02 A;  1U9X A;  4BSQ A;  2XU4 A;  1YAL A;  3WXE A;  4FK5 A;  2GFO A;  4BS6 A;  3BWK A;  1AYU A;  5CHV A;  4BOU A;  4PT5 A;  2O6X A;  1YT7 A;  4R3D A;  4PP2 E;  3MTN A;  3P5X A;  3F5V A;  2FUD A;  4GUA A;  1VSN A;  2B1N A;  3BB7 A;  3OVX A;  4RF1 A;  6PAD A;  2WBF X;  3MP2 A;  4OW0 A;  3GCB A;  1AEC A;  5J94 A;  4Q8H A;  3OF9 A;  3CH2 X;  2G8J A;  8PCH A;  4DMY A;  2E01 A;  4AXM A;  2YJB A;  3K8U A;  3CH3 X;  2AYO A;  2DOS A;  1BP4 A;  3IOQ A;  4W5C A;  2DCB A;  3TRK A;  3CBK A;  1KFX L;  4QH6 A;  4D8E A;  4X6H A;  1PE6 A;  2JQG R;  5EZQ A;  3WXG A;  4CDD B;  4MSX A;  1VJV A;  4N4Z A;  3WXF A;  1TU6 A;  4RF0 A;  3ERV A;  2HD5 A;  1K3B B;  2ACT A;  3B79 A;  3OIS A;  1AIM A;  3P5V A;  4QRV A;  2XU3 A;  1EWO A;  3KW9 A;  3OQC A;  4CZW A;  4OVZ B;  4PAD A;  2BDZ A;  2VHS A;  2YJ8 A;  4XUI A;  5EZS A;  3RVV A;  4YYQ A;  2FQ9 A;  4MZS A;  3N3K A;  1GLO A;  1HUC B;  1QMY A;  4PI3 A;  1NPZ A;  4W4U A;  4WA6 A;  4A5U A;  3B21 A;  4FIP A;  4K7C A;  3IUT A;  2AS8 A;  4RY2 A;  3IHP A;  4XR7 A;  1ICF A;  2DCA A;  3K24 A;  3PBH A;  2OP3 A;  3O0U A;  1NL6 A;  1KXR A;  1F2B A;  1PIP A;  3BY4 A;  3NHE A;  5JA7 A;  3DF0 A;  4P6E A;  2R9F A;  1KHQ A;  1PCI A;  2PNS A;  3U8E A;  1CVZ A;  2XU1 A;  3V6E A;  3KX1 A;  3O65 A;  2DJF B;  4BOZ A;  3C0R A;  2VHF A;  2NQI A;  4MI7 A;  3MJ5 A;  1S4V A;  2YJ2 A;  1AU3 A;  2HH5 A;  2R9C A;  1EWP A;  2IBI A;  1YK8 A;  3IEJ A;  1GMY A;  2BTW B;  3S3R A;  3MTV A;  3RVX A;  7PCK A;  2AIM A;  4IUM A;  1Y4H A;  4W5B A;  2DC9 A;  1ZIV A;  3HHA A;  2PBH A;  5EGW A;  4CDE B;  2UZJ A;  3BBA A;  2DJG B;  3HWN A;  1CV8 A;  3RNV A;  2R9N A;  3N3G A;  2FRQ A;  4BOP A;  1A6R A;  2PAD A;  3BOW A;  3BPM A;  3OF8 A;  5A24 A;  4I07 A;  3CBJ A;  4CDF B;  2Z84 A;  3LFY A;  5FPW A;  3PSE A;  4D8I A;  2C0Y A;  2BTW A;  1MEM A;  1PPD A;  4M0W A;  3PDF A;  2J7Q A;  3LXS A;  2OZ2 A;  4X6J A;  1U5I A;  1EF7 A;  3V6C A;  2JTC A;  1YK7 A;  3PW3 A;  1THE A;  3W31 A;  1BY8 A;  3BCN A;  3PRP A;  4YYU A;  2F1G A;  4FJC A;  4P16 A;  3MOR A;  1ME3 A;  5CVN B;  1DKI A;  1ITO A;  2AGA A;  3W30 A;  1GEC E;  1TL9 A;  4RKX A;  2ATO A;  2NQA A;  2AYN A;  2R9O A;  1PPN A;  2R6N A;  1KHP A;  1QOL A;  5CVO B;  1IWD A;  1TLO A;  1JQP A;  4QRG A;  4I05 A;  1AU4 A;  3E9S A;  4N8W A;  2AVW A;  1SP4 B;  2FTD A;  2FT2 A;  4AXL A;  3I3T A;  1CTE A;  2G7Y A;  3H8C A;  1NB5 A;  2JQF R;  1FH0 A;  5PAD A; 
#chains in the Genus database with same CATH homology
 1PAD A;  2NQG A;  2DZZ A;  4QRX A;  1F29 A;  2HHN A;  1AU2 A;  2P7U A;  3S3Q A;  1X9Y A;  4YYR A;  1Y08 A;  1F2A A;  1CS8 A;  3MHH A;  4YYS A;  3HD3 A;  1NB3 A;  5JH3 A;  1MEG A;  1MIR A;  2Y6E A;  3IMA A;  2XU5 A;  1CQD A;  1GCB A;  1AYV A;  1ME4 A;  2DCD A;  3IV2 A;  5K16 A;  3QSD A;  3H89 A;  4Q8G A;  3TNX A;  2YJC A;  2H7J A;  1NQC A;  2Y5B A;  2BSZ A;  4BPV A;  1POP A;  4OEL A;  2HXZ A;  2R9M A;  4HWY A;  4OEM A;  1PPP A;  4KLB A;  1W6F A;  2AU1 A;  3PNR A;  5EF4 A;  2CIO A;  4DMX A;  2G8E A;  1MHW A;  1CJL A;  3KWB X;  2DC8 A;  2G6D A;  4B55 A;  3C9E A;  1KFU L;  4NV7 A;  2PRE A;  2FYE A;  3I06 A;  1EWL A;  4BGF A;  1M6D A;  4I04 A;  3HHI A;  2E00 A;  1MS6 A;  1F2C A;  4N79 A;  4YYV A;  1DEU A;  1DF0 A;  3O1G A;  9PAP A;  3RVW A;  5CHT A;  1CPJ A;  3P5U A;  4X6I A;  2OUL A;  2YJ9 A;  1CSB B;  1U9Q X;  2DCC A;  3N4C A;  4CDC B;  4MZO A;  2DC7 A;  1PPO A;  3QJ3 A;  1NLJ A;  3KKU A;  1U9V A;  1O0E A;  2CB5 A;  1PBH A;  2ARY A;  5F02 A;  2P86 A;  4YVA A;  2F7D A;  1YVB A;  3MHS A;  3H7D A;  1Q6K A;  2FO5 A;  4C5P A;  4G54 A;  2AUX A;  3K9M A;  3USV A;  3KSE A;  3E1Z B;  2VFB A;  1PXV A;  3QT4 A;  1XKG A;  1U9W A;  3AI8 A;  1AYW A;  2P0R A;  3M99 A;  4QBB A;  1ZCM A;  4NV8 A;  3P5W A;  3ZUA A;  1BGO A;  2DZY A;  3KWZ A;  4YV8 A;  3H8B A;  1QXP A;  3BC3 A;  3H6S A;  1AU0 A;  1CB5 A;  2BDL A;  3KFQ A;  3BPF A;  2DC6 A;  1STF E;  1QDQ A;  1MDW A;  4BS5 A;  1ATK A;  4PP1 A;  4P6G A;  3F75 A;  2B1M A;  2IPP B;  2FRA A;  3D6S A;  2GHU A;  3LTW A;  3OVZ A;  1EWM A;  4ZUX U;  4BQV A;  2NQD B;  1BQI A;  4YYW A;  1SNK A;  5CVM A;  2AUZ A;  2E03 A;  2E02 A;  1U9X A;  4BSQ A;  2XU4 A;  1YAL A;  3WXE A;  4FK5 A;  2GFO A;  4BS6 A;  3BWK A;  1AYU A;  5CHV A;  3D9W A;  2O6X A;  1YT7 A;  4PP2 E;  3MTN A;  3P5X A;  3F5V A;  2FUD A;  1VSN A;  2B1N A;  3OVX A;  6PAD A;  2WBF X;  3GCB A;  1AEC A;  5J94 A;  4Q8H A;  3OF9 A;  3CH2 X;  2G8J A;  8PCH A;  4DMY A;  2E01 A;  4AXM A;  2YJB A;  3K8U A;  3CH3 X;  2AYO A;  1BP4 A;  3IOQ A;  4W5C A;  2DCB A;  3CBK A;  1KFX L;  4QH6 A;  4X6H A;  1PE6 A;  4GUZ A;  2JQG R;  4CDD B;  3WXG A;  4MSX A;  1VJV A;  4N4Z A;  3WXF A;  1TU6 A;  3ERV A;  2HD5 A;  1K3B B;  2ACT A;  3B79 A;  3OIS A;  1W4T A;  1AIM A;  3P5V A;  4QRV A;  2VFC A;  2XU3 A;  1EWO A;  3KW9 A;  4CZW A;  4PAD A;  2BDZ A;  2VHS A;  2YJ8 A;  4XUI A;  3RVV A;  4YYQ A;  2FQ9 A;  4MZS A;  3N3K A;  1GLO A;  1HUC B;  1QMY A;  4PI3 A;  1NPZ A;  4W4U A;  4WA6 A;  4FIP A;  4K7C A;  3IUT A;  2AS8 A;  4RY2 A;  3IHP A;  4XR7 A;  1ICF A;  2DCA A;  3K24 A;  3PBH A;  2OP3 A;  3O0U A;  1NL6 A;  1KXR A;  1F2B A;  1PIP A;  3NHE A;  5JA7 A;  3DF0 A;  4P6E A;  2R9F A;  1KHQ A;  1PCI A;  2PNS A;  3U8E A;  1CVZ A;  2XU1 A;  3V6E A;  3KX1 A;  2DJF B;  2VHF A;  2NQI A;  1S4V A;  2YJ2 A;  1AU3 A;  2HH5 A;  2R9C A;  1EWP A;  2IBI A;  1YK8 A;  3IEJ A;  1GMY A;  3S3R A;  3RVX A;  7PCK A;  2AIM A;  1Y4H A;  4W5B A;  2DC9 A;  1ZIV A;  3HHA A;  2PBH A;  5EGW A;  4CDE B;  2DJG B;  3HWN A;  1CV8 A;  2R9N A;  3N3G A;  2FRQ A;  1E2T A;  1A6R A;  2PAD A;  3BOW A;  3BPM A;  3OF8 A;  5A24 A;  4I07 A;  3CBJ A;  4CDF B;  3LFY A;  5FPW A;  1W5R A;  2C0Y A;  1MEM A;  1PPD A;  3PDF A;  3LXS A;  4X6J A;  2OZ2 A;  1U5I A;  1EF7 A;  3V6C A;  1YK7 A;  3PW3 A;  1THE A;  1BY8 A;  3BCN A;  4YYU A;  2F1G A;  4FJC A;  3MOR A;  1ME3 A;  5CVN B;  1ITO A;  1GEC E;  1TL9 A;  2ATO A;  2NQA A;  2AYN A;  2R9O A;  1PPN A;  2R6N A;  1KHP A;  1QOL A;  5CVO B;  1IWD A;  1TLO A;  1JQP A;  4QRG A;  4I05 A;  1AU4 A;  4N8W A;  2AVW A;  1SP4 B;  2FTD A;  2FT2 A;  4AXL A;  3I3T A;  1CTE A;  2G7Y A;  3H8C A;  1NB5 A;  1GX3 A;  2JQF R;  1FH0 A;  5PAD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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