4YV8A

Crystal structure of cathepsin k bound to the covalent inhibitor lichostatinal
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
213
structure length
213
Chain Sequence
DSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
pubmed doi rcsb
molecule tags Hydrolase/inhibitor
source organism Homo sapiens
molecule keywords Cathepsin K
total genus 65
structure length 213
sequence length 213
ec nomenclature ec 3.4.22.38: Cathepsin K.
pdb deposition date 2015-03-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4yv8A00
1IWDA 1NQCA 1XKGA 3WXGA 4W5CA 2DCBA 2E03A 3BPMA 4QRVA 2YJCA 4FIPA 1SNKA 1JQPA 2R9MA 1U9XA 4YYQA 2YJ8A 1TL9A 5A24A 3OVXA 4QRGA 1YALA 4QH6A 3O0UA 3I06A 2FYEA 1HUCB 1Y08A 2VHSA 4PI3A 4QBBA 1U9VA 2Y6EA 1U9WA 3IUTA 4W4UA 1M6DA 4MSXA 3V6CA 1BGOA 3IHPA 3BCNA 1AU4A 1AYWA 2IBIA 4BQVA 3D6SA 1S4VA 4YYRA 4Q8GA 3V6EA 3KFQA 3CBJA 1QDQA 3HHIA 1X9YA 2AS8A 1F29A 1AU0A 2FRQA 4CDFB 5CVOB 2P0RA 1EWMA 1PBHA 2G8EA 2ARYA 3M99A 3H89A 3CBKA 1ZCMA 3K9MA 3GCBA 2E00A 1DEUA 2ATOA 2XU3A 2XU4A 2AIMA 4N4ZA 3P5VA 1CB5A 4X6HA 2R9CA 1THEA 2Y5BA 3P5UA 1CVZA 2E02A 3HWNA 4YYWA 9PAPA 2HHNA 1AYVA 1CPJA 5JA7A 3OF8A 2DJFB 2C0YA 1QMYA 2FUDA 3KSEA 2CB5A 3E1ZB 1CQDA 1MDWA 4BPVA 2H7JA 1PADA 2G7YA 2YJ2A 2B1MA 4BSQA 2R9NA 1ME4A 3ZUAA 1ITOA 4YV8A 2R9FA 4CZWA 3O1GA 4DMXA 2NQAA 3N3KA 1KHPA 3MORA 1Y4HA 3BC3A 1EWLA 1ZIVA 3U8EA 2P86A 1EWPA 3RVWA 3S3RA 3DF0A 4CDEB 1QXPA 1Q6KA 1DF0A 1AU2A 1VSNA 3H7DA 3PBHA 4XUIA 4PP1A 4K7CA 4YYVA 3MHHA 1CS8A 3LFYA 2F1GA 1K3BB 1PPDA 3P5WA 6PADA 2DCCA 1ICFA 4WA6A 3H6SA 5K16A 2DC9A 3OF9A 4YYSA 1CV8A 1AIMA 4OELA 3PW3A 2DZZA 1NL6A 1ME3A 4BS5A 1F2CA 2F7DA 3QJ3A 1FH0A 2BDLA 4OEMA 3NHEA 2FRAA 3AI8A 4N79A 3PDFA 2P7UA 4CDCB 1SP4B 2IPPB 1QOLA 4AXMA 1O0EA 2AYNA 4DMYA 2DC6A 2PREA 5CHTA 1CJLA 1YT7A 4RY2A 3KWBX 4KLBA 8PCHA 5CHVA 1MIRA 3RVVA 4X6JA 3H8CA 3P5XA 2GHUA 2BDZA 2PADA 2FTDA 5J94A 1KFUL 2GFOA 1PPNA 3WXFA 1TLOA 4P6EA 2WBFX 1PPOA 3KKUA 2HXZA 4N8WA 3PNRA 1KXRA 2R9OA 1U9QX 3F75A 1MHWA 1AYUA 2CIOA 4MZSA 3KW9A 3N3GA 2B1NA 3USVA 1VJVA 3BWKA 1EF7A 4I07A 1GMYA 1YVBA 1A6RA 3MTNA 4CDDB 4AXLA 1KHQA 1NPZA 4P6GA 1PPPA 3WXEA 2FT2A 3S3QA 1GCBA 5PADA 3CH2X 2PBHA 3KX1A 7PCKA 4PP2E 5F02A 4G54A 3QT4A 3LXSA 4I04A 2DC7A 3RVXA 2VHFA 4YVAA 3N4CA 1ATKA 3OVZA 1PE6A 4PADA 4BS6A 2HH5A 5FPWA 4I05A 3K8UA 1PXVA 4ZUXU 1NLJA 3IV2A 3HHAA 5EGWA 2AVWA 3IEJA 1KFXL 4FK5A 1PCIA 2AU1A 3I3TA 2PNSA 2ACTA 2FQ9A 1YK7A 2OULA 1BP4A 3BPFA 1BY8A 1EWOA 4X6IA 1MS6A 5EF4A 1AECA 2G6DA 3F5VA 1NB5A 2JQFR 3HD3A 3IMAA 1YK8A 2JQGR 2OP3A 3IOQA 3OISA 1F2BA 2O6XA 2NQDB 3B79A 3CH3X 5CVNB 2AUXA 3H8BA 2YJ9A 2DC8A 2DCAA 1NB3A 1PIPA 2DZYA 2R6NA 1MEMA 3BOWA 2NQGA 3K24A 4XR7A 5JH3A 4MZOA 3KWZA 1MEGA 3TNXA 3QSDA 2E01A 2OZ2A 1U5IA 1CSBB 2HD5A 4W5BA 2XU1A 2DJGB 4HWYA 1AU3A 1BQIA 1F2AA 1POPA 4YYUA 4FJCA 4QRXA 5CVMA 2G8JA 3MHSA 1CTEA 1GECE 2XU5A 2DCDA 2AYOA 1TU6A 3ERVA 1GLOA 4Q8HA 2FO5A 2NQIA 2YJBA 2AUZA 1STFE 3C9EA
chains in the Genus database with same CATH superfamily
1IWDA 1NQCA 1XKGA 3WXGA 3BBAA 4W5CA 2DCBA 2E03A 3BPMA 4QRVA 4REZA 2YJCA 4FIPA 2Z84A 1SNKA 1JQPA 2R9MA 1U9XA 4YYQA 2YJ8A 1TL9A 5A24A 3OVXA 4QRGA 1YALA 4QH6A 3O0UA 3MP2A 3I06A 3MJ5A 4A5UA 2FYEA 1HUCB 1Y08A 2VHSA 4PI3A 4QBBA 1U9VA 2Y6EA 1U9WA 3IUTA 4W4UA 1M6DA 4MSXA 3V6CA 1BGOA 3IHPA 2J7QC 3BCNA 4D8IA 3PHXA 1AU4A 1AYWA 2IBIA 4BQVA 3D6SA 4BOPA 3O65A 1S4VA 2BTWA 3PT2A 4YYRA 4Q8GA 5EZSA 3V6EA 3KFQA 3CBJA 1QDQA 3HHIA 1X9YA 2AS8A 1F29A 1AU0A 1DKIA 2FRQA 4XZXA 4CDFB 5CVOB 2P0RA 1EWMA 4IP3A 1PBHA 2G8EA 5EZQA 2ARYA 3M99A 3H89A 3CBKA 1ZCMA 3W31A 4OVZA 3K9MA 3GCBA 4M0WA 2E00A 1DEUA 2ATOA 2XU3A 2XU4A 3TMPA 2AIMA 4N4ZA 4RF0A 3P5VA 1CB5A 4X6HA 2R9CA 1THEA 2Y5BA 3P5UA 1CVZA 2E02A 3HWNA 3W30A 3B21A 4YYWA 9PAPA 2HHNA 1AYVA 1CPJA 5JA7A 3OF8A 2DJFB 4P16A 2C0YA 1QMYA 3PRMA 2FUDA 3KSEA 2CB5A 3E1ZB 1CQDA 1MDWA 4BPVA 3E9SA 2H7JA 1PADA 2G7YA 2YJ2A 2B1MA 4BSQA 2R9NA 1ME4A 3ZUAA 1ITOA 4YV8A 2R9FA 4CZWA 3O1GA 4DMXA 2NQAA 3N3KA 1KHPA 3MORA 1Y4HA 3BC3A 1EWLA 1ZIVA 3U8EA 3PHUA 2P86A 1EWPA 3RVWA 3S3RA 3DF0A 4CDEB 1QXPA 1Q6KA 1DF0A 1AU2A 1VSNA 3H7DA 3PBHA 4XUIA 4PP1A 4K7CA 4YYVA 3MHHA 1CS8A 3LFYA 2F1GA 1K3BB 1PPDA 3P5WA 6PADA 2DCCA 1ICFA 4WA6A 3H6SA 5K16A 2DC9A 3OF9A 4YYSA 1CV8A 4R3DA 1AIMA 4BOQA 4MI7A 4OELA 3PW3A 2DZZA 1NL6A 1ME3A 4BS5A 1F2CA 2FE8A 2F7DA 3C0RA 3QJ3A 1FH0A 2UZJA 2BDLA 4OEMA 3NHEA 2FRAA 3AI8A 4N79A 3PDFA 2P7UA 4CDCB 4HXDB 4OW0A 1SP4B 2IPPB 1QOLA 4AXMA 1O0EA 2AYNA 4DMYA 2DC6A 2PREA 2BU3A 5CHTA 1CJLA 2HWKA 1YT7A 5JZEA 4RY2A 3KWBX 4KLBA 8PCHA 1PVJA 5CHVA 1MIRA 3RVVA 4ZTBA 4X6JA 1UKFA 3H8CA 3P5XA 4BOZA 2GHUA 2BDZA 2PADA 2FTDA 5J94A 1KFUL 2GFOA 1PPNA 3MTVA 3WXFA 3PRPA 1TLOA 4P6EA 2WBFX 1PPOA 3KKUA 2HXZA 4N8WA 3PNRA 4MM3B 1KXRA 2R9OA 1U9QX 3F75A 1MHWA 1AYUA 2CIOA 4MZSA 3KW9A 3N3GA 2B1NA 3USVA 1VJVA 3BB7A 3BWKA 4IUMA 1EF7A 4I07A 2JTCA 5E6JA 1GMYA 1YVBA 4RF1A 1A6RA 3MTNA 4CDDB 4AXLA 2BTWB 1KHQA 3RNVA 1NPZA 4P6GA 1PPPA 3WXEA 2FT2A 3S3QA 1GCBA 5PADA 3CH2X 2PBHA 3KX1A 7PCKA 4PP2E 5F02A 4G54A 3QT4A 3PSEA 4BOSA 3LXSA 4I04A 2DC7A 4OVZB 3RVXA 2VHFA 4YVAA 3N4CA 1ATKA 4WURA 3OVZA 1PE6A 4PADA 4BS6A 2HH5A 5FPWA 4I05A 3K8UA 1PXVA 4ZUXU 1NLJA 2JRIA 3IV2A 3HHAA 5EGWA 2AVWA 3IEJA 1KFXL 4FK5A 1PCIA 2AU1A 3I3TA 4RNAA 2PNSA 2ACTA 2FQ9A 1YK7A 3BY4A 2OULA 1BP4A 3BPFA 4PT5A 1BY8A 1EWOA 4X6IA 1MS6A 5EF4A 1AECA 2G6DA 3F5VA 1NB5A 2JQFR 2J7QA 3HD3A 3IMAA 3OQCA 1YK8A 2JQGR 2OP3A 3IOQA 3OISA 1F2BA 2O6XA 2NQDB 3B79A 3CH3X 3ZNHA 5CVNB 2AUXA 3H8BA 5KO3A 2YJ9A 2DC8A 2DCAA 1NB3A 2AGAA 1PIPA 2DZYA 2R6NA 1MEMA 4RKXA 3BOWA 4GUAA 4D8EA 2NQGA 3K24A 4XR7A 5JH3A 3IFUA 4MZOA 3KWZA 1MEGA 3TNXA 3QSDA 2E01A 2OZ2A 1U5IA 1CSBB 2HD5A 4W5BA 2XU1A 2DJGB 4HWYA 1AU3A 1BQIA 1F2AA 1POPA 4YYUA 4FJCA 4QRXA 5CVMA 4BOUA 2G8JA 3MHSA 1CTEA 4D8BA 1GECE 2XU5A 2DCDA 2AYOA 3PHWA 1TU6A 3ERVA 1GLOA 4Q8HA 3TRKA 2FO5A 2NQIA 2YJBA 1YZBA 2DOSA 2AUZA 1STFE 3C9EA
chains in the Genus database with same CATH topology
1IWDA 1NQCA 1XKGA 3LTWA 3WXGA 4W5CA 2DCBA 2E03A 3BPMA 4QRVA 2YJCA 4B55A 4FIPA 1SNKA 1JQPA 2R9MA 1U9XA 4YYQA 2YJ8A 1TL9A 5A24A 3OVXA 4QRGA 1YALA 4QH6A 3O0UA 3I06A 2FYEA 1HUCB 1Y08A 2VHSA 4PI3A 4QBBA 1U9VA 2Y6EA 1U9WA 3IUTA 4W4UA 1M6DA 4MSXA 3V6CA 1BGOA 3IHPA 3BCNA 1AU4A 1AYWA 2IBIA 4BQVA 3D6SA 1S4VA 4YYRA 4Q8GA 3V6EA 3KFQA 3CBJA 1QDQA 3HHIA 1X9YA 2AS8A 1F29A 1AU0A 2FRQA 4CDFB 5CVOB 2P0RA 1EWMA 1PBHA 2G8EA 2ARYA 3M99A 3H89A 3CBKA 1ZCMA 2VFCA 3K9MA 3GCBA 2E00A 1DEUA 2ATOA 2XU3A 2XU4A 2AIMA 4N4ZA 3P5VA 1CB5A 4X6HA 2R9CA 1THEA 2Y5BA 3P5UA 1CVZA 2E02A 3HWNA 4YYWA 9PAPA 2HHNA 1AYVA 1CPJA 5JA7A 3OF8A 2DJFB 2C0YA 1QMYA 2FUDA 4BGFA 3KSEA 2CB5A 3E1ZB 1CQDA 1MDWA 4BPVA 2H7JA 1PADA 2G7YA 2YJ2A 2B1MA 4BSQA 2R9NA 1ME4A 3D9WA 3ZUAA 1ITOA 4YV8A 2R9FA 4CZWA 3O1GA 4DMXA 2NQAA 3N3KA 1KHPA 3MORA 1Y4HA 3BC3A 1EWLA 1ZIVA 3U8EA 2P86A 1EWPA 3RVWA 3S3RA 3DF0A 4CDEB 1QXPA 1Q6KA 1DF0A 1AU2A 1VSNA 3H7DA 3PBHA 1E2TA 4XUIA 4PP1A 4K7CA 4YYVA 3MHHA 1CS8A 3LFYA 2F1GA 1K3BB 1PPDA 3P5WA 6PADA 2DCCA 1ICFA 4WA6A 3H6SA 5K16A 2DC9A 3OF9A 4YYSA 1CV8A 1AIMA 4OELA 3PW3A 2DZZA 1NL6A 1ME3A 4BS5A 1F2CA 2F7DA 3QJ3A 1FH0A 2BDLA 4OEMA 3NHEA 2FRAA 3AI8A 4N79A 3PDFA 2P7UA 4CDCB 1SP4B 2IPPB 1QOLA 4AXMA 1O0EA 2AYNA 4DMYA 4NV7A 2DC6A 4NV8A 4C5PA 2PREA 5CHTA 1CJLA 1YT7A 4RY2A 3KWBX 4KLBA 8PCHA 5CHVA 1MIRA 3RVVA 4X6JA 3H8CA 3P5XA 2GHUA 2BDZA 2PADA 2FTDA 5J94A 1KFUL 2GFOA 1PPNA 3WXFA 1TLOA 4P6EA 2WBFX 1PPOA 3KKUA 2HXZA 4N8WA 3PNRA 1KXRA 2R9OA 1U9QX 3F75A 1MHWA 1AYUA 2CIOA 4MZSA 3KW9A 3N3GA 2B1NA 3USVA 1VJVA 3BWKA 2VFBA 1EF7A 4I07A 1W5RA 1GMYA 1YVBA 1A6RA 3MTNA 4CDDB 4AXLA 1KHQA 1NPZA 4P6GA 1PPPA 3WXEA 2FT2A 3S3QA 1GCBA 5PADA 3CH2X 2PBHA 3KX1A 7PCKA 4PP2E 5F02A 4G54A 3QT4A 3LXSA 4I04A 2DC7A 1W6FA 3RVXA 2VHFA 4YVAA 3N4CA 1ATKA 3OVZA 1PE6A 4PADA 4BS6A 2HH5A 5FPWA 4I05A 3K8UA 1GX3A 1PXVA 4ZUXU 1NLJA 3IV2A 3HHAA 5EGWA 2AVWA 3IEJA 1KFXL 4FK5A 1PCIA 2AU1A 4GUZA 3I3TA 2PNSA 2ACTA 2FQ9A 1YK7A 2OULA 1BP4A 3BPFA 1BY8A 1EWOA 1W4TA 1MS6A 4X6IA 5EF4A 1AECA 2G6DA 3F5VA 1NB5A 2JQFR 3HD3A 3IMAA 1YK8A 2JQGR 2OP3A 3IOQA 3OISA 1F2BA 2O6XA 2NQDB 3B79A 3CH3X 5CVNB 2AUXA 3H8BA 2YJ9A 2DC8A 2DCAA 1NB3A 1PIPA 2DZYA 2R6NA 1MEMA 3BOWA 2NQGA 3K24A 4XR7A 5JH3A 4MZOA 3KWZA 1MEGA 3TNXA 3QSDA 2BSZA 2E01A 2OZ2A 1U5IA 1CSBB 2HD5A 4W5BA 2XU1A 2DJGB 4HWYA 1AU3A 1BQIA 1F2AA 1POPA 4YYUA 4FJCA 4QRXA 5CVMA 2G8JA 3MHSA 1CTEA 1GECE 2XU5A 2DCDA 2AYOA 1TU6A 3ERVA 1GLOA 4Q8HA 2FO5A 2NQIA 2YJBA 2AUZA 1STFE 3C9EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IWD A;  1NQC A;  1XKG A;  3WXG A;  4W5C A;  2DCB A;  2E03 A;  3BPM A;  4QRV A;  2YJC A;  4FIP A;  1SNK A;  1JQP A;  2R9M A;  1U9X A;  4YYQ A;  2YJ8 A;  1TL9 A;  5A24 A;  3OVX A;  4QRG A;  1YAL A;  4QH6 A;  3O0U A;  3I06 A;  2FYE A;  1HUC B;  1Y08 A;  2VHS A;  4PI3 A;  4QBB A;  1U9V A;  2Y6E A;  1U9W A;  3IUT A;  4W4U A;  1M6D A;  4MSX A;  3V6C A;  1BGO A;  3IHP A;  3BCN A;  1AU4 A;  1AYW A;  2IBI A;  4BQV A;  3D6S A;  1S4V A;  4YYR A;  4Q8G A;  3V6E A;  3KFQ A;  3CBJ A;  1QDQ A;  3HHI A;  1X9Y A;  2AS8 A;  1F29 A;  1AU0 A;  2FRQ A;  4CDF B;  5CVO B;  2P0R A;  1EWM A;  1PBH A;  2G8E A;  2ARY A;  3M99 A;  3H89 A;  3CBK A;  1ZCM A;  3K9M A;  3GCB A;  2E00 A;  1DEU A;  2ATO A;  2XU3 A;  2XU4 A;  2AIM A;  4N4Z A;  3P5V A;  1CB5 A;  4X6H A;  2R9C A;  1THE A;  2Y5B A;  3P5U A;  1CVZ A;  2E02 A;  3HWN A;  4YYW A;  9PAP A;  2HHN A;  1AYV A;  1CPJ A;  5JA7 A;  3OF8 A;  2DJF B;  2C0Y A;  1QMY A;  2FUD A;  3KSE A;  2CB5 A;  3E1Z B;  1CQD A;  1MDW A;  4BPV A;  2H7J A;  1PAD A;  2G7Y A;  2YJ2 A;  2B1M A;  4BSQ A;  2R9N A;  1ME4 A;  3ZUA A;  1ITO A;  4YV8 A;  2R9F A;  4CZW A;  3O1G A;  4DMX A;  2NQA A;  3N3K A;  1KHP A;  3MOR A;  1Y4H A;  3BC3 A;  1EWL A;  1ZIV A;  3U8E A;  2P86 A;  1EWP A;  3RVW A;  3S3R A;  3DF0 A;  4CDE B;  1QXP A;  1Q6K A;  1DF0 A;  1AU2 A;  1VSN A;  3H7D A;  3PBH A;  4XUI A;  4PP1 A;  4K7C A;  4YYV A;  3MHH A;  1CS8 A;  3LFY A;  2F1G A;  1K3B B;  1PPD A;  3P5W A;  6PAD A;  2DCC A;  1ICF A;  4WA6 A;  3H6S A;  5K16 A;  2DC9 A;  3OF9 A;  4YYS A;  1CV8 A;  1AIM A;  4OEL A;  3PW3 A;  2DZZ A;  1NL6 A;  1ME3 A;  4BS5 A;  1F2C A;  2F7D A;  3QJ3 A;  1FH0 A;  2BDL A;  4OEM A;  3NHE A;  2FRA A;  3AI8 A;  4N79 A;  3PDF A;  2P7U A;  4CDC B;  1SP4 B;  2IPP B;  1QOL A;  4AXM A;  1O0E A;  2AYN A;  4DMY A;  2DC6 A;  2PRE A;  5CHT A;  1CJL A;  1YT7 A;  4RY2 A;  3KWB X;  4KLB A;  8PCH A;  5CHV A;  1MIR A;  3RVV A;  4X6J A;  3H8C A;  3P5X A;  2GHU A;  2BDZ A;  2PAD A;  2FTD A;  5J94 A;  1KFU L;  2GFO A;  1PPN A;  3WXF A;  1TLO A;  4P6E A;  2WBF X;  1PPO A;  3KKU A;  2HXZ A;  4N8W A;  3PNR A;  1KXR A;  2R9O A;  1U9Q X;  3F75 A;  1MHW A;  1AYU A;  2CIO A;  4MZS A;  3KW9 A;  3N3G A;  2B1N A;  3USV A;  1VJV A;  3BWK A;  1EF7 A;  4I07 A;  1GMY A;  1YVB A;  1A6R A;  3MTN A;  4CDD B;  4AXL A;  1KHQ A;  1NPZ A;  4P6G A;  1PPP A;  3WXE A;  2FT2 A;  3S3Q A;  1GCB A;  5PAD A;  3CH2 X;  2PBH A;  3KX1 A;  7PCK A;  4PP2 E;  5F02 A;  4G54 A;  3QT4 A;  3LXS A;  4I04 A;  2DC7 A;  3RVX A;  2VHF A;  4YVA A;  3N4C A;  1ATK A;  3OVZ A;  1PE6 A;  4PAD A;  4BS6 A;  2HH5 A;  5FPW A;  4I05 A;  3K8U A;  1PXV A;  4ZUX U;  1NLJ A;  3IV2 A;  3HHA A;  5EGW A;  2AVW A;  3IEJ A;  1KFX L;  4FK5 A;  1PCI A;  2AU1 A;  3I3T A;  2PNS A;  2ACT A;  2FQ9 A;  1YK7 A;  2OUL A;  1BP4 A;  3BPF A;  1BY8 A;  1EWO A;  4X6I A;  1MS6 A;  5EF4 A;  1AEC A;  2G6D A;  3F5V A;  1NB5 A;  2JQF R;  3HD3 A;  3IMA A;  1YK8 A;  2JQG R;  2OP3 A;  3IOQ A;  3OIS A;  1F2B A;  2O6X A;  2NQD B;  3B79 A;  3CH3 X;  5CVN B;  2AUX A;  3H8B A;  2YJ9 A;  2DC8 A;  2DCA A;  1NB3 A;  1PIP A;  2DZY A;  2R6N A;  1MEM A;  3BOW A;  2NQG A;  3K24 A;  4XR7 A;  5JH3 A;  4MZO A;  3KWZ A;  1MEG A;  3TNX A;  3QSD A;  2E01 A;  2OZ2 A;  1U5I A;  1CSB B;  2HD5 A;  4W5B A;  2XU1 A;  2DJG B;  4HWY A;  1AU3 A;  1BQI A;  1F2A A;  1POP A;  4YYU A;  4FJC A;  4QRX A;  5CVM A;  2G8J A;  3MHS A;  1CTE A;  1GEC E;  2XU5 A;  2DCD A;  2AYO A;  1TU6 A;  3ERV A;  1GLO A;  4Q8H A;  2FO5 A;  2NQI A;  2YJB A;  2AUZ A;  1STF E;  3C9E A; 
#chains in the Genus database with same CATH topology
 1IWD A;  1NQC A;  1XKG A;  3WXG A;  3BBA A;  4W5C A;  2DCB A;  2E03 A;  3BPM A;  4QRV A;  4REZ A;  2YJC A;  4FIP A;  2Z84 A;  1SNK A;  1JQP A;  2R9M A;  1U9X A;  4YYQ A;  2YJ8 A;  1TL9 A;  5A24 A;  3OVX A;  4QRG A;  1YAL A;  4QH6 A;  3O0U A;  3MP2 A;  3I06 A;  3MJ5 A;  4A5U A;  2FYE A;  1HUC B;  1Y08 A;  2VHS A;  4PI3 A;  4QBB A;  1U9V A;  2Y6E A;  1U9W A;  3IUT A;  4W4U A;  1M6D A;  4MSX A;  3V6C A;  1BGO A;  3IHP A;  2J7Q C;  3BCN A;  4D8I A;  3PHX A;  1AU4 A;  1AYW A;  2IBI A;  4BQV A;  3D6S A;  4BOP A;  3O65 A;  1S4V A;  2BTW A;  3PT2 A;  4YYR A;  4Q8G A;  5EZS A;  3V6E A;  3KFQ A;  3CBJ A;  1QDQ A;  3HHI A;  1X9Y A;  2AS8 A;  1F29 A;  1AU0 A;  1DKI A;  2FRQ A;  4XZX A;  4CDF B;  5CVO B;  2P0R A;  1EWM A;  4IP3 A;  1PBH A;  2G8E A;  5EZQ A;  2ARY A;  3M99 A;  3H89 A;  3CBK A;  1ZCM A;  3W31 A;  4OVZ A;  3K9M A;  3GCB A;  4M0W A;  2E00 A;  1DEU A;  2ATO A;  2XU3 A;  2XU4 A;  3TMP A;  2AIM A;  4N4Z A;  4RF0 A;  3P5V A;  1CB5 A;  4X6H A;  2R9C A;  1THE A;  2Y5B A;  3P5U A;  1CVZ A;  2E02 A;  3HWN A;  3W30 A;  3B21 A;  4YYW A;  9PAP A;  2HHN A;  1AYV A;  1CPJ A;  5JA7 A;  3OF8 A;  2DJF B;  4P16 A;  2C0Y A;  1QMY A;  3PRM A;  2FUD A;  3KSE A;  2CB5 A;  3E1Z B;  1CQD A;  1MDW A;  4BPV A;  3E9S A;  2H7J A;  1PAD A;  2G7Y A;  2YJ2 A;  2B1M A;  4BSQ A;  2R9N A;  1ME4 A;  3ZUA A;  1ITO A;  4YV8 A;  2R9F A;  4CZW A;  3O1G A;  4DMX A;  2NQA A;  3N3K A;  1KHP A;  3MOR A;  1Y4H A;  3BC3 A;  1EWL A;  1ZIV A;  3U8E A;  3PHU A;  2P86 A;  1EWP A;  3RVW A;  3S3R A;  3DF0 A;  4CDE B;  1QXP A;  1Q6K A;  1DF0 A;  1AU2 A;  1VSN A;  3H7D A;  3PBH A;  4XUI A;  4PP1 A;  4K7C A;  4YYV A;  3MHH A;  1CS8 A;  3LFY A;  2F1G A;  1K3B B;  1PPD A;  3P5W A;  6PAD A;  2DCC A;  1ICF A;  4WA6 A;  3H6S A;  5K16 A;  2DC9 A;  3OF9 A;  4YYS A;  1CV8 A;  4R3D A;  1AIM A;  4BOQ A;  4MI7 A;  4OEL A;  3PW3 A;  2DZZ A;  1NL6 A;  1ME3 A;  4BS5 A;  1F2C A;  2FE8 A;  2F7D A;  3C0R A;  3QJ3 A;  1FH0 A;  2UZJ A;  2BDL A;  4OEM A;  3NHE A;  2FRA A;  3AI8 A;  4N79 A;  3PDF A;  2P7U A;  4CDC B;  4HXD B;  4OW0 A;  1SP4 B;  2IPP B;  1QOL A;  4AXM A;  1O0E A;  2AYN A;  4DMY A;  2DC6 A;  2PRE A;  2BU3 A;  5CHT A;  1CJL A;  2HWK A;  1YT7 A;  5JZE A;  4RY2 A;  3KWB X;  4KLB A;  8PCH A;  1PVJ A;  5CHV A;  1MIR A;  3RVV A;  4ZTB A;  4X6J A;  1UKF A;  3H8C A;  3P5X A;  4BOZ A;  2GHU A;  2BDZ A;  2PAD A;  2FTD A;  5J94 A;  1KFU L;  2GFO A;  1PPN A;  3MTV A;  3WXF A;  3PRP A;  1TLO A;  4P6E A;  2WBF X;  1PPO A;  3KKU A;  2HXZ A;  4N8W A;  3PNR A;  4MM3 B;  1KXR A;  2R9O A;  1U9Q X;  3F75 A;  1MHW A;  1AYU A;  2CIO A;  4MZS A;  3KW9 A;  3N3G A;  2B1N A;  3USV A;  1VJV A;  3BB7 A;  3BWK A;  4IUM A;  1EF7 A;  4I07 A;  2JTC A;  5E6J A;  1GMY A;  1YVB A;  4RF1 A;  1A6R A;  3MTN A;  4CDD B;  4AXL A;  2BTW B;  1KHQ A;  3RNV A;  1NPZ A;  4P6G A;  1PPP A;  3WXE A;  2FT2 A;  3S3Q A;  1GCB A;  5PAD A;  3CH2 X;  2PBH A;  3KX1 A;  7PCK A;  4PP2 E;  5F02 A;  4G54 A;  3QT4 A;  3PSE A;  4BOS A;  3LXS A;  4I04 A;  2DC7 A;  4OVZ B;  3RVX A;  2VHF A;  4YVA A;  3N4C A;  1ATK A;  4WUR A;  3OVZ A;  1PE6 A;  4PAD A;  4BS6 A;  2HH5 A;  5FPW A;  4I05 A;  3K8U A;  1PXV A;  4ZUX U;  1NLJ A;  2JRI A;  3IV2 A;  3HHA A;  5EGW A;  2AVW A;  3IEJ A;  1KFX L;  4FK5 A;  1PCI A;  2AU1 A;  3I3T A;  4RNA A;  2PNS A;  2ACT A;  2FQ9 A;  1YK7 A;  3BY4 A;  2OUL A;  1BP4 A;  3BPF A;  4PT5 A;  1BY8 A;  1EWO A;  4X6I A;  1MS6 A;  5EF4 A;  1AEC A;  2G6D A;  3F5V A;  1NB5 A;  2JQF R;  2J7Q A;  3HD3 A;  3IMA A;  3OQC A;  1YK8 A;  2JQG R;  2OP3 A;  3IOQ A;  3OIS A;  1F2B A;  2O6X A;  2NQD B;  3B79 A;  3CH3 X;  3ZNH A;  5CVN B;  2AUX A;  3H8B A;  5KO3 A;  2YJ9 A;  2DC8 A;  2DCA A;  1NB3 A;  2AGA A;  1PIP A;  2DZY A;  2R6N A;  1MEM A;  4RKX A;  3BOW A;  4GUA A;  4D8E A;  2NQG A;  3K24 A;  4XR7 A;  5JH3 A;  3IFU A;  4MZO A;  3KWZ A;  1MEG A;  3TNX A;  3QSD A;  2E01 A;  2OZ2 A;  1U5I A;  1CSB B;  2HD5 A;  4W5B A;  2XU1 A;  2DJG B;  4HWY A;  1AU3 A;  1BQI A;  1F2A A;  1POP A;  4YYU A;  4FJC A;  4QRX A;  5CVM A;  4BOU A;  2G8J A;  3MHS A;  1CTE A;  4D8B A;  1GEC E;  2XU5 A;  2DCD A;  2AYO A;  3PHW A;  1TU6 A;  3ERV A;  1GLO A;  4Q8H A;  3TRK A;  2FO5 A;  2NQI A;  2YJB A;  1YZB A;  2DOS A;  2AUZ A;  1STF E;  3C9E A; 
#chains in the Genus database with same CATH homology
 1IWD A;  1NQC A;  1XKG A;  3LTW A;  3WXG A;  4W5C A;  2DCB A;  2E03 A;  3BPM A;  4QRV A;  2YJC A;  4B55 A;  4FIP A;  1SNK A;  1JQP A;  2R9M A;  1U9X A;  4YYQ A;  2YJ8 A;  1TL9 A;  5A24 A;  3OVX A;  4QRG A;  1YAL A;  4QH6 A;  3O0U A;  3I06 A;  2FYE A;  1HUC B;  1Y08 A;  2VHS A;  4PI3 A;  4QBB A;  1U9V A;  2Y6E A;  1U9W A;  3IUT A;  4W4U A;  1M6D A;  4MSX A;  3V6C A;  1BGO A;  3IHP A;  3BCN A;  1AU4 A;  1AYW A;  2IBI A;  4BQV A;  3D6S A;  1S4V A;  4YYR A;  4Q8G A;  3V6E A;  3KFQ A;  3CBJ A;  1QDQ A;  3HHI A;  1X9Y A;  2AS8 A;  1F29 A;  1AU0 A;  2FRQ A;  4CDF B;  5CVO B;  2P0R A;  1EWM A;  1PBH A;  2G8E A;  2ARY A;  3M99 A;  3H89 A;  3CBK A;  1ZCM A;  2VFC A;  3K9M A;  3GCB A;  2E00 A;  1DEU A;  2ATO A;  2XU3 A;  2XU4 A;  2AIM A;  4N4Z A;  3P5V A;  1CB5 A;  4X6H A;  2R9C A;  1THE A;  2Y5B A;  3P5U A;  1CVZ A;  2E02 A;  3HWN A;  4YYW A;  9PAP A;  2HHN A;  1AYV A;  1CPJ A;  5JA7 A;  3OF8 A;  2DJF B;  2C0Y A;  1QMY A;  2FUD A;  4BGF A;  3KSE A;  2CB5 A;  3E1Z B;  1CQD A;  1MDW A;  4BPV A;  2H7J A;  1PAD A;  2G7Y A;  2YJ2 A;  2B1M A;  4BSQ A;  2R9N A;  1ME4 A;  3D9W A;  3ZUA A;  1ITO A;  4YV8 A;  2R9F A;  4CZW A;  3O1G A;  4DMX A;  2NQA A;  3N3K A;  1KHP A;  3MOR A;  1Y4H A;  3BC3 A;  1EWL A;  1ZIV A;  3U8E A;  2P86 A;  1EWP A;  3RVW A;  3S3R A;  3DF0 A;  4CDE B;  1QXP A;  1Q6K A;  1DF0 A;  1AU2 A;  1VSN A;  3H7D A;  3PBH A;  1E2T A;  4XUI A;  4PP1 A;  4K7C A;  4YYV A;  3MHH A;  1CS8 A;  3LFY A;  2F1G A;  1K3B B;  1PPD A;  3P5W A;  6PAD A;  2DCC A;  1ICF A;  4WA6 A;  3H6S A;  5K16 A;  2DC9 A;  3OF9 A;  4YYS A;  1CV8 A;  1AIM A;  4OEL A;  3PW3 A;  2DZZ A;  1NL6 A;  1ME3 A;  4BS5 A;  1F2C A;  2F7D A;  3QJ3 A;  1FH0 A;  2BDL A;  4OEM A;  3NHE A;  2FRA A;  3AI8 A;  4N79 A;  3PDF A;  2P7U A;  4CDC B;  1SP4 B;  2IPP B;  1QOL A;  4AXM A;  1O0E A;  2AYN A;  4DMY A;  4NV7 A;  2DC6 A;  4NV8 A;  4C5P A;  2PRE A;  5CHT A;  1CJL A;  1YT7 A;  4RY2 A;  3KWB X;  4KLB A;  8PCH A;  5CHV A;  1MIR A;  3RVV A;  4X6J A;  3H8C A;  3P5X A;  2GHU A;  2BDZ A;  2PAD A;  2FTD A;  5J94 A;  1KFU L;  2GFO A;  1PPN A;  3WXF A;  1TLO A;  4P6E A;  2WBF X;  1PPO A;  3KKU A;  2HXZ A;  4N8W A;  3PNR A;  1KXR A;  2R9O A;  1U9Q X;  3F75 A;  1MHW A;  1AYU A;  2CIO A;  4MZS A;  3KW9 A;  3N3G A;  2B1N A;  3USV A;  1VJV A;  3BWK A;  2VFB A;  1EF7 A;  4I07 A;  1W5R A;  1GMY A;  1YVB A;  1A6R A;  3MTN A;  4CDD B;  4AXL A;  1KHQ A;  1NPZ A;  4P6G A;  1PPP A;  3WXE A;  2FT2 A;  3S3Q A;  1GCB A;  5PAD A;  3CH2 X;  2PBH A;  3KX1 A;  7PCK A;  4PP2 E;  5F02 A;  4G54 A;  3QT4 A;  3LXS A;  4I04 A;  2DC7 A;  1W6F A;  3RVX A;  2VHF A;  4YVA A;  3N4C A;  1ATK A;  3OVZ A;  1PE6 A;  4PAD A;  4BS6 A;  2HH5 A;  5FPW A;  4I05 A;  3K8U A;  1GX3 A;  1PXV A;  4ZUX U;  1NLJ A;  3IV2 A;  3HHA A;  5EGW A;  2AVW A;  3IEJ A;  1KFX L;  4FK5 A;  1PCI A;  2AU1 A;  4GUZ A;  3I3T A;  2PNS A;  2ACT A;  2FQ9 A;  1YK7 A;  2OUL A;  1BP4 A;  3BPF A;  1BY8 A;  1EWO A;  1W4T A;  1MS6 A;  4X6I A;  5EF4 A;  1AEC A;  2G6D A;  3F5V A;  1NB5 A;  2JQF R;  3HD3 A;  3IMA A;  1YK8 A;  2JQG R;  2OP3 A;  3IOQ A;  3OIS A;  1F2B A;  2O6X A;  2NQD B;  3B79 A;  3CH3 X;  5CVN B;  2AUX A;  3H8B A;  2YJ9 A;  2DC8 A;  2DCA A;  1NB3 A;  1PIP A;  2DZY A;  2R6N A;  1MEM A;  3BOW A;  2NQG A;  3K24 A;  4XR7 A;  5JH3 A;  4MZO A;  3KWZ A;  1MEG A;  3TNX A;  3QSD A;  2BSZ A;  2E01 A;  2OZ2 A;  1U5I A;  1CSB B;  2HD5 A;  4W5B A;  2XU1 A;  2DJG B;  4HWY A;  1AU3 A;  1BQI A;  1F2A A;  1POP A;  4YYU A;  4FJC A;  4QRX A;  5CVM A;  2G8J A;  3MHS A;  1CTE A;  1GEC E;  2XU5 A;  2DCD A;  2AYO A;  1TU6 A;  3ERV A;  1GLO A;  4Q8H A;  2FO5 A;  2NQI A;  2YJB A;  2AUZ A;  1STF E;  3C9E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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