4PI3A

Crystal structure analysis of cruzain bound to vinyl sulfone analog of wrr-483 (wrr-666)
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Trypanosoma cruzi
molecule keywords Cruzipain
total genus 69
structure length 215
sequence length 215
chains with identical sequence B
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2014-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4pi3A00
4X6IA 4DMYA 4MZSA 1THEA 2DJFB 3IV2A 2R9CA 4W5CA 1U9XA 2HD5A 4OEMA 5EGWA 3CH3X 5FPWA 1YALA 3BPMA 1FH0A 3F5VA 2E00A 2H7JA 3WXFA 1NB5A 1X9YA 1ZIVA 3V6EA 2BDLA 2YJ9A 4Q8HA 2YJCA 1GLOA 1O0EA 2DCDA 1AYUA 2G8JA 2FUDA 1GECE 2R9OA 4YYVA 1F2CA 2P0RA 2DCBA 3P5WA 1MDWA 1Y4HA 1AU4A 1PE6A 1CPJA 4FK5A 3H7DA 2P7UA 3O0UA 2FT2A 3N4CA 1BY8A 2Y6EA 4BS6A 4PP2E 4PI3A 3HD3A 3F75A 2AUXA 1MEGA 3KX1A 1SNKA 2DC6A 1AU2A 2XU1A 3S3QA 1VSNA 4CDCB 4I07A 1AU3A 2IPPB 4QH6A 2AS8A 5PADA 1EWOA 1STFE 2PBHA 3U8EA 2YJ2A 4BQVA 3IEJA 3KW9A 2ACTA 4QRXA 4W4UA 3BWKA 1AU0A 2AVWA 4CDFB 1NLJA 3P5UA 1PXVA 3HHAA 1KFUL 3PW3A 5EF4A 1NB3A 4XUIA 2XU5A 4Q8GA 2CB5A 1MHWA 1EWPA 2AYNA 4QBBA 2BDZA 2XU4A 1XKGA 3ZUAA 3OF9A 3H89A 1CB5A 1BGOA 2FO5A 4YYSA 1AECA 2ATOA 4CDEB 5CHVA 3N3GA 1GMYA 1MEMA 1KHQA 2VHFA 2YJBA 4P6EA 3CBJA 5JH3A 2FQ9A 2HHNA 1EWMA 1QDQA 3IUTA 1NPZA 3C9EA 1BP4A 4FIPA 1ICFA 1F29A 2F1GA 4OELA 1QMYA 3B79A 5J94A 1F2AA 1U9VA 3WXEA 2OULA 3KSEA 2CIOA 4ZUXU 2DC7A 5A24A 5CVNB 1KHPA 3I3TA 2Y5BA 3KFQA 2PREA 4W5BA 2NQDB 1QOLA 2DZZA 4YYUA 2DCCA 3GCBA 2F7DA 2G6DA 4KLBA 4DMXA 3MHHA 9PAPA 1YK8A 8PCHA 4K7CA 2PADA 3H8BA 3K24A 2E02A 1EWLA 1S4VA 2DJGB 2NQAA 2E03A 1ME3A 4CDDB 4RY2A 1VJVA 1HUCB 1QXPA 3RVXA 1PPOA 2FRQA 1A6RA 2E01A 2HH5A 4YYQA 1KFXL 2VHSA 1ATKA 1NL6A 3LXSA 2DC8A 5K16A 3D6SA 2GHUA 1YT7A 4AXMA 4N79A 5CVOB 1PPPA 4YV8A 1MIRA 3OISA 2AYOA 3QSDA 3OF8A 2R6NA 4HWYA 3H6SA 2NQGA 3ERVA 4XR7A 3HHIA 1CQDA 3N3KA 2IBIA 4I04A 3KWBX 3IOQA 1PBHA 4AXLA 3USVA 7PCKA 4N8WA 4P6GA 1EF7A 2AUZA 2DC9A 3E1ZB 1KXRA 4X6HA 3P5VA 4BS5A 3DF0A 1U5IA 3BCNA 3PDFA 4WA6A 3S3RA 3K8UA 2R9FA 1PPDA 3MTNA 2OZ2A 1PADA 3WXGA 2FRAA 1SP4B 1U9QX 1NQCA 1K3BB 2ARYA 1IWDA 3BOWA 1Q6KA 2B1MA 2HXZA 4MZOA 1PPNA 3CBKA 1F2BA 3LFYA 3PNRA 1DEUA 3KWZA 2JQFR 3I06A 2FTDA 2WBFX 3KKUA 4QRVA 1TU6A 1CJLA 4X6JA 2B1NA 2JQGR 1CV8A 5CHTA 3O1GA 3BC3A 3HWNA 3IMAA 2PNSA 1M6DA 2C0YA 1JQPA 1TL9A 2DZYA 2P86A 4G54A 4BPVA 5CVMA 1AIMA 4I05A 4PADA 4QRGA 4YYRA 1CTEA 2OP3A 1ZCMA 3RVWA 4YVAA 3RVVA 3P5XA 3QT4A 1POPA 3QJ3A 3V6CA 1CVZA 1GCBA 1YVBA 3IHPA 4FJCA 5F02A 1DF0A 2FYEA 3PBHA 3CH2X 4PP1A 1PCIA 6PADA 1Y08A 1ITOA 1PIPA 2AU1A 4MSXA 2G8EA 2R9MA 3OVXA 1MS6A 2DCAA 1TLOA 2XU3A 1AYVA 2AIMA 2G7YA 3H8CA 2O6XA 2GFOA 3MHSA 5JA7A 1ME4A 4N4ZA 3BPFA 1AYWA 4CZWA 2R9NA 3TNXA 2YJ8A 1YK7A 3OVZA 3AI8A 4BSQA 1CSBB 1CS8A 3M99A 2NQIA 3NHEA 3MORA 1U9WA 3K9MA 1BQIA 4YYWA
chains in the Genus database with same CATH superfamily
4X6IA 4DMYA 4MZSA 1THEA 2DJFB 3IV2A 2R9CA 4W5CA 1U9XA 2HD5A 3TRKA 4OEMA 5EGWA 3CH3X 5FPWA 1YALA 3BPMA 1FH0A 3F5VA 2E00A 2H7JA 3WXFA 1NB5A 1X9YA 1ZIVA 3V6EA 2BDLA 2YJ9A 4Q8HA 2YJCA 1GLOA 1O0EA 2DCDA 3PHWA 1AYUA 2G8JA 2FUDA 1GECE 2R9OA 3PRMA 4YYVA 1F2CA 2P0RA 2DCBA 3P5WA 1MDWA 1Y4HA 1AU4A 1PE6A 1CPJA 4FK5A 1UKFA 5E6JA 3H7DA 2P7UA 3O0UA 2FT2A 3N4CA 1BY8A 2Y6EA 3W30A 4BS6A 4PP2E 4PI3A 3HD3A 3F75A 2AUXA 1MEGA 3KX1A 1SNKA 2DC6A 1AU2A 4A5UA 4D8BA 2XU1A 4RKXA 3S3QA 2FE8A 1VSNA 4CDCB 4I07A 1AU3A 2IPPB 4R3DA 5EZSA 4QH6A 2AS8A 5PADA 4P16A 1EWOA 1STFE 3PRPA 2PBHA 3U8EA 2YJ2A 4BQVA 3IEJA 3KW9A 3PT2A 2ACTA 4QRXA 4W4UA 2J7QC 3BWKA 3PHUA 1AU0A 2AVWA 4CDFB 1NLJA 3P5UA 1PXVA 3HHAA 1KFUL 3PW3A 5EF4A 1NB3A 4XUIA 2XU5A 4Q8GA 4RF0A 2CB5A 1MHWA 4WURA 1EWPA 2AYNA 4OVZA 4REZA 4QBBA 2BDZA 2XU4A 1XKGA 3ZUAA 3OF9A 4OVZB 3H89A 1CB5A 1BGOA 2FO5A 4YYSA 1AECA 2ATOA 4CDEB 5CHVA 3N3GA 1GMYA 5EZQA 1MEMA 1KHQA 2VHFA 2YJBA 4P6EA 3TMPA 3CBJA 5JH3A 2FQ9A 2HHNA 1EWMA 1QDQA 3IUTA 1NPZA 3C9EA 1BP4A 3PHXA 4FIPA 1ICFA 1F29A 2F1GA 4OELA 1QMYA 3B79A 4BOZA 5J94A 1F2AA 4RNAA 3C0RA 1U9VA 3WXEA 2OULA 4IP3A 3KSEA 2BTWA 2CIOA 1DKIA 4D8IA 3MP2A 4ZUXU 2DC7A 5A24A 5KO3A 5CVNB 1KHPA 3I3TA 2Y5BA 3KFQA 2PREA 2BTWB 4W5BA 2NQDB 1QOLA 2DZZA 4YYUA 2AGAA 2DCCA 3MTVA 3GCBA 2F7DA 4BOPA 2G6DA 4KLBA 4DMXA 4XZXA 3MHHA 9PAPA 2UZJA 1YK8A 8PCHA 4K7CA 2PADA 4OW0A 3H8BA 3K24A 2E02A 1EWLA 1S4VA 2DJGB 2NQAA 2E03A 1ME3A 4CDDB 4RY2A 1VJVA 1HUCB 4PT5A 1QXPA 3RVXA 1PPOA 2FRQA 1A6RA 2E01A 2HH5A 3B21A 4YYQA 1KFXL 2VHSA 5JZEA 1ATKA 1NL6A 2J7QA 2HWKA 3LXSA 2DC8A 5K16A 3D6SA 2GHUA 1YT7A 4AXMA 4N79A 5CVOB 1PPPA 4YV8A 1MIRA 3OISA 2AYOA 3QSDA 4ZTBA 3OF8A 2BU3A 2R6NA 4HWYA 3H6SA 2NQGA 3ERVA 4XR7A 3HHIA 1CQDA 3N3KA 2IBIA 4I04A 3KWBX 3IOQA 3ZNHA 3IFUA 1PBHA 4AXLA 3USVA 7PCKA 4N8WA 1YZBA 4P6GA 4D8EA 3BBAA 1EF7A 2AUZA 2DOSA 2DC9A 3E1ZB 1PVJA 1KXRA 3OQCA 4X6HA 3P5VA 4BS5A 3DF0A 1U5IA 3BCNA 3PDFA 4WA6A 3S3RA 3MJ5A 3K8UA 2R9FA 1PPDA 3BB7A 3MTNA 2OZ2A 1PADA 4MI7A 3WXGA 2FRAA 1SP4B 1U9QX 1NQCA 2JRIA 1K3BB 2ARYA 1IWDA 3BOWA 1Q6KA 2B1MA 2HXZA 4MZOA 1PPNA 3CBKA 1F2BA 3LFYA 3PNRA 1DEUA 3KWZA 2JQFR 3I06A 3BY4A 4MM3B 2FTDA 2WBFX 3KKUA 4QRVA 1TU6A 1CJLA 3RNVA 4X6JA 2B1NA 2JQGR 1CV8A 4HXDB 5CHTA 3E9SA 3O1GA 3BC3A 3HWNA 4RF1A 4M0WA 4BOQA 3IMAA 2PNSA 1M6DA 2C0YA 1JQPA 1TL9A 2DZYA 2P86A 4G54A 4BPVA 5CVMA 1AIMA 4I05A 4PADA 4QRGA 4YYRA 1CTEA 2OP3A 1ZCMA 3RVWA 4YVAA 2Z84A 3RVVA 3P5XA 3QT4A 1POPA 3QJ3A 3V6CA 1CVZA 1GCBA 1YVBA 3IHPA 4FJCA 5F02A 1DF0A 2FYEA 3PBHA 3CH2X 4PP1A 1PCIA 6PADA 1Y08A 3O65A 1ITOA 1PIPA 2AU1A 2G8EA 2R9MA 3OVXA 4MSXA 1MS6A 2DCAA 1TLOA 2XU3A 1AYVA 3W31A 2AIMA 2G7YA 3H8CA 2O6XA 4BOUA 2GFOA 3MHSA 5JA7A 1ME4A 4N4ZA 3BPFA 1AYWA 4CZWA 2R9NA 3TNXA 2YJ8A 1YK7A 3OVZA 3AI8A 4BSQA 4BOSA 1CSBB 4IUMA 3PSEA 1CS8A 3M99A 4GUAA 2NQIA 3NHEA 2JTCA 3MORA 1U9WA 3K9MA 1BQIA 4YYWA
chains in the Genus database with same CATH topology
4X6IA 4DMYA 3LTWA 4MZSA 1THEA 2DJFB 3IV2A 2R9CA 4W5CA 1U9XA 2HD5A 4OEMA 5EGWA 3CH3X 5FPWA 1YALA 3BPMA 1FH0A 3F5VA 2E00A 2H7JA 3WXFA 1NB5A 1X9YA 1ZIVA 3V6EA 2BDLA 2YJ9A 4Q8HA 2YJCA 1GLOA 1O0EA 2DCDA 1AYUA 2G8JA 2FUDA 1GECE 2R9OA 4BGFA 4YYVA 1F2CA 2P0RA 2DCBA 3P5WA 1MDWA 1Y4HA 1AU4A 1PE6A 1CPJA 4FK5A 1W5RA 3H7DA 2P7UA 3O0UA 2FT2A 3N4CA 1BY8A 2Y6EA 4BS6A 4PP2E 4PI3A 3HD3A 3F75A 2AUXA 1MEGA 3KX1A 1SNKA 2DC6A 1AU2A 2XU1A 3S3QA 1VSNA 4CDCB 4I07A 1AU3A 2IPPB 4QH6A 2AS8A 4NV8A 5PADA 1EWOA 1STFE 2PBHA 3U8EA 2YJ2A 4BQVA 3IEJA 3KW9A 2ACTA 4QRXA 4W4UA 3BWKA 1AU0A 2AVWA 4CDFB 1NLJA 3P5UA 1PXVA 3HHAA 1KFUL 3PW3A 5EF4A 1NB3A 4XUIA 2XU5A 4Q8GA 2CB5A 1MHWA 1EWPA 2AYNA 4QBBA 2BDZA 2XU4A 1XKGA 3ZUAA 3OF9A 3H89A 1CB5A 1BGOA 2FO5A 4YYSA 1AECA 2ATOA 4CDEB 5CHVA 3N3GA 1GMYA 1MEMA 1KHQA 2VHFA 2YJBA 4P6EA 3CBJA 5JH3A 2VFBA 2FQ9A 4B55A 2HHNA 4GUZA 1EWMA 1QDQA 3IUTA 1NPZA 3C9EA 1BP4A 4FIPA 1ICFA 1F29A 2F1GA 4OELA 1QMYA 3B79A 5J94A 1F2AA 1U9VA 3WXEA 2OULA 3KSEA 2CIOA 4ZUXU 2DC7A 5A24A 5CVNB 1KHPA 3I3TA 2Y5BA 3KFQA 2PREA 4W5BA 2NQDB 1QOLA 2DZZA 4YYUA 2DCCA 3GCBA 2F7DA 2G6DA 4KLBA 4DMXA 3MHHA 9PAPA 4NV7A 1YK8A 8PCHA 4K7CA 2PADA 3H8BA 3K24A 2E02A 1EWLA 1S4VA 2DJGB 2NQAA 2E03A 1ME3A 4CDDB 4RY2A 1VJVA 1HUCB 1QXPA 3RVXA 1PPOA 2FRQA 1A6RA 2E01A 2HH5A 4YYQA 1KFXL 2VHSA 1ATKA 1NL6A 3LXSA 2DC8A 5K16A 3D6SA 2GHUA 1YT7A 4AXMA 4N79A 5CVOB 1PPPA 4YV8A 1MIRA 3OISA 2AYOA 3QSDA 3D9WA 3OF8A 2R6NA 4HWYA 3H6SA 2NQGA 3ERVA 4XR7A 3HHIA 1CQDA 3N3KA 2IBIA 4I04A 3KWBX 3IOQA 1PBHA 4AXLA 3USVA 7PCKA 4N8WA 4P6GA 1EF7A 2VFCA 2AUZA 2DC9A 3E1ZB 1KXRA 4X6HA 1GX3A 3P5VA 4BS5A 3DF0A 1U5IA 3BCNA 3PDFA 4WA6A 3S3RA 3K8UA 2R9FA 1PPDA 3MTNA 2OZ2A 1PADA 3WXGA 2FRAA 2BSZA 1SP4B 1U9QX 1NQCA 1K3BB 2ARYA 1IWDA 3BOWA 1Q6KA 2B1MA 2HXZA 4MZOA 1PPNA 3CBKA 1F2BA 3LFYA 3PNRA 1DEUA 3KWZA 2JQFR 3I06A 2FTDA 2WBFX 3KKUA 4QRVA 1TU6A 1CJLA 4X6JA 2B1NA 2JQGR 1CV8A 5CHTA 1E2TA 3O1GA 1W4TA 3BC3A 3HWNA 3IMAA 2PNSA 1M6DA 2C0YA 1JQPA 1TL9A 2DZYA 2P86A 4G54A 4BPVA 5CVMA 1AIMA 4I05A 4PADA 4QRGA 4YYRA 1CTEA 2OP3A 4C5PA 1ZCMA 3RVWA 4YVAA 3RVVA 3P5XA 3QT4A 1POPA 3QJ3A 3V6CA 1CVZA 1GCBA 1YVBA 3IHPA 4FJCA 5F02A 1DF0A 2FYEA 3PBHA 3CH2X 4PP1A 1PCIA 6PADA 1Y08A 1ITOA 1PIPA 2AU1A 4MSXA 2G8EA 2R9MA 3OVXA 1MS6A 2DCAA 1TLOA 2XU3A 1AYVA 2AIMA 2G7YA 3H8CA 2O6XA 2GFOA 3MHSA 5JA7A 1ME4A 4N4ZA 3BPFA 1AYWA 4CZWA 2R9NA 3TNXA 2YJ8A 1YK7A 3OVZA 3AI8A 4BSQA 1CSBB 1CS8A 1W6FA 3M99A 2NQIA 3NHEA 3MORA 1U9WA 3K9MA 1BQIA 4YYWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X6I A;  4DMY A;  4MZS A;  1THE A;  2DJF B;  3IV2 A;  2R9C A;  4W5C A;  1U9X A;  2HD5 A;  4OEM A;  5EGW A;  3CH3 X;  5FPW A;  1YAL A;  3BPM A;  1FH0 A;  3F5V A;  2E00 A;  2H7J A;  3WXF A;  1NB5 A;  1X9Y A;  1ZIV A;  3V6E A;  2BDL A;  2YJ9 A;  4Q8H A;  2YJC A;  1GLO A;  1O0E A;  2DCD A;  1AYU A;  2G8J A;  2FUD A;  1GEC E;  2R9O A;  4YYV A;  1F2C A;  2P0R A;  2DCB A;  3P5W A;  1MDW A;  1Y4H A;  1AU4 A;  1PE6 A;  1CPJ A;  4FK5 A;  3H7D A;  2P7U A;  3O0U A;  2FT2 A;  3N4C A;  1BY8 A;  2Y6E A;  4BS6 A;  4PP2 E;  4PI3 A;  3HD3 A;  3F75 A;  2AUX A;  1MEG A;  3KX1 A;  1SNK A;  2DC6 A;  1AU2 A;  2XU1 A;  3S3Q A;  1VSN A;  4CDC B;  4I07 A;  1AU3 A;  2IPP B;  4QH6 A;  2AS8 A;  5PAD A;  1EWO A;  1STF E;  2PBH A;  3U8E A;  2YJ2 A;  4BQV A;  3IEJ A;  3KW9 A;  2ACT A;  4QRX A;  4W4U A;  3BWK A;  1AU0 A;  2AVW A;  4CDF B;  1NLJ A;  3P5U A;  1PXV A;  3HHA A;  1KFU L;  3PW3 A;  5EF4 A;  1NB3 A;  4XUI A;  2XU5 A;  4Q8G A;  2CB5 A;  1MHW A;  1EWP A;  2AYN A;  4QBB A;  2BDZ A;  2XU4 A;  1XKG A;  3ZUA A;  3OF9 A;  3H89 A;  1CB5 A;  1BGO A;  2FO5 A;  4YYS A;  1AEC A;  2ATO A;  4CDE B;  5CHV A;  3N3G A;  1GMY A;  1MEM A;  1KHQ A;  2VHF A;  2YJB A;  4P6E A;  3CBJ A;  5JH3 A;  2FQ9 A;  2HHN A;  1EWM A;  1QDQ A;  3IUT A;  1NPZ A;  3C9E A;  1BP4 A;  4FIP A;  1ICF A;  1F29 A;  2F1G A;  4OEL A;  1QMY A;  3B79 A;  5J94 A;  1F2A A;  1U9V A;  3WXE A;  2OUL A;  3KSE A;  2CIO A;  4ZUX U;  2DC7 A;  5A24 A;  5CVN B;  1KHP A;  3I3T A;  2Y5B A;  3KFQ A;  2PRE A;  4W5B A;  2NQD B;  1QOL A;  2DZZ A;  4YYU A;  2DCC A;  3GCB A;  2F7D A;  2G6D A;  4KLB A;  4DMX A;  3MHH A;  9PAP A;  1YK8 A;  8PCH A;  4K7C A;  2PAD A;  3H8B A;  3K24 A;  2E02 A;  1EWL A;  1S4V A;  2DJG B;  2NQA A;  2E03 A;  1ME3 A;  4CDD B;  4RY2 A;  1VJV A;  1HUC B;  1QXP A;  3RVX A;  1PPO A;  2FRQ A;  1A6R A;  2E01 A;  2HH5 A;  4YYQ A;  1KFX L;  2VHS A;  1ATK A;  1NL6 A;  3LXS A;  2DC8 A;  5K16 A;  3D6S A;  2GHU A;  1YT7 A;  4AXM A;  4N79 A;  5CVO B;  1PPP A;  4YV8 A;  1MIR A;  3OIS A;  2AYO A;  3QSD A;  3OF8 A;  2R6N A;  4HWY A;  3H6S A;  2NQG A;  3ERV A;  4XR7 A;  3HHI A;  1CQD A;  3N3K A;  2IBI A;  4I04 A;  3KWB X;  3IOQ A;  1PBH A;  4AXL A;  3USV A;  7PCK A;  4N8W A;  4P6G A;  1EF7 A;  2AUZ A;  2DC9 A;  3E1Z B;  1KXR A;  4X6H A;  3P5V A;  4BS5 A;  3DF0 A;  1U5I A;  3BCN A;  3PDF A;  4WA6 A;  3S3R A;  3K8U A;  2R9F A;  1PPD A;  3MTN A;  2OZ2 A;  1PAD A;  3WXG A;  2FRA A;  1SP4 B;  1U9Q X;  1NQC A;  1K3B B;  2ARY A;  1IWD A;  3BOW A;  1Q6K A;  2B1M A;  2HXZ A;  4MZO A;  1PPN A;  3CBK A;  1F2B A;  3LFY A;  3PNR A;  1DEU A;  3KWZ A;  2JQF R;  3I06 A;  2FTD A;  2WBF X;  3KKU A;  4QRV A;  1TU6 A;  1CJL A;  4X6J A;  2B1N A;  2JQG R;  1CV8 A;  5CHT A;  3O1G A;  3BC3 A;  3HWN A;  3IMA A;  2PNS A;  1M6D A;  2C0Y A;  1JQP A;  1TL9 A;  2DZY A;  2P86 A;  4G54 A;  4BPV A;  5CVM A;  1AIM A;  4I05 A;  4PAD A;  4QRG A;  4YYR A;  1CTE A;  2OP3 A;  1ZCM A;  3RVW A;  4YVA A;  3RVV A;  3P5X A;  3QT4 A;  1POP A;  3QJ3 A;  3V6C A;  1CVZ A;  1GCB A;  1YVB A;  3IHP A;  4FJC A;  5F02 A;  1DF0 A;  2FYE A;  3PBH A;  3CH2 X;  4PP1 A;  1PCI A;  6PAD A;  1Y08 A;  1ITO A;  1PIP A;  2AU1 A;  4MSX A;  2G8E A;  2R9M A;  3OVX A;  1MS6 A;  2DCA A;  1TLO A;  2XU3 A;  1AYV A;  2AIM A;  2G7Y A;  3H8C A;  2O6X A;  2GFO A;  3MHS A;  5JA7 A;  1ME4 A;  4N4Z A;  3BPF A;  1AYW A;  4CZW A;  2R9N A;  3TNX A;  2YJ8 A;  1YK7 A;  3OVZ A;  3AI8 A;  4BSQ A;  1CSB B;  1CS8 A;  3M99 A;  2NQI A;  3NHE A;  3MOR A;  1U9W A;  3K9M A;  1BQI A;  4YYW A; 
#chains in the Genus database with same CATH topology
 4X6I A;  4DMY A;  4MZS A;  1THE A;  2DJF B;  3IV2 A;  2R9C A;  4W5C A;  1U9X A;  2HD5 A;  3TRK A;  4OEM A;  5EGW A;  3CH3 X;  5FPW A;  1YAL A;  3BPM A;  1FH0 A;  3F5V A;  2E00 A;  2H7J A;  3WXF A;  1NB5 A;  1X9Y A;  1ZIV A;  3V6E A;  2BDL A;  2YJ9 A;  4Q8H A;  2YJC A;  1GLO A;  1O0E A;  2DCD A;  3PHW A;  1AYU A;  2G8J A;  2FUD A;  1GEC E;  2R9O A;  3PRM A;  4YYV A;  1F2C A;  2P0R A;  2DCB A;  3P5W A;  1MDW A;  1Y4H A;  1AU4 A;  1PE6 A;  1CPJ A;  4FK5 A;  1UKF A;  5E6J A;  3H7D A;  2P7U A;  3O0U A;  2FT2 A;  3N4C A;  1BY8 A;  2Y6E A;  3W30 A;  4BS6 A;  4PP2 E;  4PI3 A;  3HD3 A;  3F75 A;  2AUX A;  1MEG A;  3KX1 A;  1SNK A;  2DC6 A;  1AU2 A;  4A5U A;  4D8B A;  2XU1 A;  4RKX A;  3S3Q A;  2FE8 A;  1VSN A;  4CDC B;  4I07 A;  1AU3 A;  2IPP B;  4R3D A;  5EZS A;  4QH6 A;  2AS8 A;  5PAD A;  4P16 A;  1EWO A;  1STF E;  3PRP A;  2PBH A;  3U8E A;  2YJ2 A;  4BQV A;  3IEJ A;  3KW9 A;  3PT2 A;  2ACT A;  4QRX A;  4W4U A;  2J7Q C;  3BWK A;  3PHU A;  1AU0 A;  2AVW A;  4CDF B;  1NLJ A;  3P5U A;  1PXV A;  3HHA A;  1KFU L;  3PW3 A;  5EF4 A;  1NB3 A;  4XUI A;  2XU5 A;  4Q8G A;  4RF0 A;  2CB5 A;  1MHW A;  4WUR A;  1EWP A;  2AYN A;  4OVZ A;  4REZ A;  4QBB A;  2BDZ A;  2XU4 A;  1XKG A;  3ZUA A;  3OF9 A;  4OVZ B;  3H89 A;  1CB5 A;  1BGO A;  2FO5 A;  4YYS A;  1AEC A;  2ATO A;  4CDE B;  5CHV A;  3N3G A;  1GMY A;  5EZQ A;  1MEM A;  1KHQ A;  2VHF A;  2YJB A;  4P6E A;  3TMP A;  3CBJ A;  5JH3 A;  2FQ9 A;  2HHN A;  1EWM A;  1QDQ A;  3IUT A;  1NPZ A;  3C9E A;  1BP4 A;  3PHX A;  4FIP A;  1ICF A;  1F29 A;  2F1G A;  4OEL A;  1QMY A;  3B79 A;  4BOZ A;  5J94 A;  1F2A A;  4RNA A;  3C0R A;  1U9V A;  3WXE A;  2OUL A;  4IP3 A;  3KSE A;  2BTW A;  2CIO A;  1DKI A;  4D8I A;  3MP2 A;  4ZUX U;  2DC7 A;  5A24 A;  5KO3 A;  5CVN B;  1KHP A;  3I3T A;  2Y5B A;  3KFQ A;  2PRE A;  2BTW B;  4W5B A;  2NQD B;  1QOL A;  2DZZ A;  4YYU A;  2AGA A;  2DCC A;  3MTV A;  3GCB A;  2F7D A;  4BOP A;  2G6D A;  4KLB A;  4DMX A;  4XZX A;  3MHH A;  9PAP A;  2UZJ A;  1YK8 A;  8PCH A;  4K7C A;  2PAD A;  4OW0 A;  3H8B A;  3K24 A;  2E02 A;  1EWL A;  1S4V A;  2DJG B;  2NQA A;  2E03 A;  1ME3 A;  4CDD B;  4RY2 A;  1VJV A;  1HUC B;  4PT5 A;  1QXP A;  3RVX A;  1PPO A;  2FRQ A;  1A6R A;  2E01 A;  2HH5 A;  3B21 A;  4YYQ A;  1KFX L;  2VHS A;  5JZE A;  1ATK A;  1NL6 A;  2J7Q A;  2HWK A;  3LXS A;  2DC8 A;  5K16 A;  3D6S A;  2GHU A;  1YT7 A;  4AXM A;  4N79 A;  5CVO B;  1PPP A;  4YV8 A;  1MIR A;  3OIS A;  2AYO A;  3QSD A;  4ZTB A;  3OF8 A;  2BU3 A;  2R6N A;  4HWY A;  3H6S A;  2NQG A;  3ERV A;  4XR7 A;  3HHI A;  1CQD A;  3N3K A;  2IBI A;  4I04 A;  3KWB X;  3IOQ A;  3ZNH A;  3IFU A;  1PBH A;  4AXL A;  3USV A;  7PCK A;  4N8W A;  1YZB A;  4P6G A;  4D8E A;  3BBA A;  1EF7 A;  2AUZ A;  2DOS A;  2DC9 A;  3E1Z B;  1PVJ A;  1KXR A;  3OQC A;  4X6H A;  3P5V A;  4BS5 A;  3DF0 A;  1U5I A;  3BCN A;  3PDF A;  4WA6 A;  3S3R A;  3MJ5 A;  3K8U A;  2R9F A;  1PPD A;  3BB7 A;  3MTN A;  2OZ2 A;  1PAD A;  4MI7 A;  3WXG A;  2FRA A;  1SP4 B;  1U9Q X;  1NQC A;  2JRI A;  1K3B B;  2ARY A;  1IWD A;  3BOW A;  1Q6K A;  2B1M A;  2HXZ A;  4MZO A;  1PPN A;  3CBK A;  1F2B A;  3LFY A;  3PNR A;  1DEU A;  3KWZ A;  2JQF R;  3I06 A;  3BY4 A;  4MM3 B;  2FTD A;  2WBF X;  3KKU A;  4QRV A;  1TU6 A;  1CJL A;  3RNV A;  4X6J A;  2B1N A;  2JQG R;  1CV8 A;  4HXD B;  5CHT A;  3E9S A;  3O1G A;  3BC3 A;  3HWN A;  4RF1 A;  4M0W A;  4BOQ A;  3IMA A;  2PNS A;  1M6D A;  2C0Y A;  1JQP A;  1TL9 A;  2DZY A;  2P86 A;  4G54 A;  4BPV A;  5CVM A;  1AIM A;  4I05 A;  4PAD A;  4QRG A;  4YYR A;  1CTE A;  2OP3 A;  1ZCM A;  3RVW A;  4YVA A;  2Z84 A;  3RVV A;  3P5X A;  3QT4 A;  1POP A;  3QJ3 A;  3V6C A;  1CVZ A;  1GCB A;  1YVB A;  3IHP A;  4FJC A;  5F02 A;  1DF0 A;  2FYE A;  3PBH A;  3CH2 X;  4PP1 A;  1PCI A;  6PAD A;  1Y08 A;  3O65 A;  1ITO A;  1PIP A;  2AU1 A;  2G8E A;  2R9M A;  3OVX A;  4MSX A;  1MS6 A;  2DCA A;  1TLO A;  2XU3 A;  1AYV A;  3W31 A;  2AIM A;  2G7Y A;  3H8C A;  2O6X A;  4BOU A;  2GFO A;  3MHS A;  5JA7 A;  1ME4 A;  4N4Z A;  3BPF A;  1AYW A;  4CZW A;  2R9N A;  3TNX A;  2YJ8 A;  1YK7 A;  3OVZ A;  3AI8 A;  4BSQ A;  4BOS A;  1CSB B;  4IUM A;  3PSE A;  1CS8 A;  3M99 A;  4GUA A;  2NQI A;  3NHE A;  2JTC A;  3MOR A;  1U9W A;  3K9M A;  1BQI A;  4YYW A; 
#chains in the Genus database with same CATH homology
 4X6I A;  4DMY A;  3LTW A;  4MZS A;  1THE A;  2DJF B;  3IV2 A;  2R9C A;  4W5C A;  1U9X A;  2HD5 A;  4OEM A;  5EGW A;  3CH3 X;  5FPW A;  1YAL A;  3BPM A;  1FH0 A;  3F5V A;  2E00 A;  2H7J A;  3WXF A;  1NB5 A;  1X9Y A;  1ZIV A;  3V6E A;  2BDL A;  2YJ9 A;  4Q8H A;  2YJC A;  1GLO A;  1O0E A;  2DCD A;  1AYU A;  2G8J A;  2FUD A;  1GEC E;  2R9O A;  4BGF A;  4YYV A;  1F2C A;  2P0R A;  2DCB A;  3P5W A;  1MDW A;  1Y4H A;  1AU4 A;  1PE6 A;  1CPJ A;  4FK5 A;  1W5R A;  3H7D A;  2P7U A;  3O0U A;  2FT2 A;  3N4C A;  1BY8 A;  2Y6E A;  4BS6 A;  4PP2 E;  4PI3 A;  3HD3 A;  3F75 A;  2AUX A;  1MEG A;  3KX1 A;  1SNK A;  2DC6 A;  1AU2 A;  2XU1 A;  3S3Q A;  1VSN A;  4CDC B;  4I07 A;  1AU3 A;  2IPP B;  4QH6 A;  2AS8 A;  4NV8 A;  5PAD A;  1EWO A;  1STF E;  2PBH A;  3U8E A;  2YJ2 A;  4BQV A;  3IEJ A;  3KW9 A;  2ACT A;  4QRX A;  4W4U A;  3BWK A;  1AU0 A;  2AVW A;  4CDF B;  1NLJ A;  3P5U A;  1PXV A;  3HHA A;  1KFU L;  3PW3 A;  5EF4 A;  1NB3 A;  4XUI A;  2XU5 A;  4Q8G A;  2CB5 A;  1MHW A;  1EWP A;  2AYN A;  4QBB A;  2BDZ A;  2XU4 A;  1XKG A;  3ZUA A;  3OF9 A;  3H89 A;  1CB5 A;  1BGO A;  2FO5 A;  4YYS A;  1AEC A;  2ATO A;  4CDE B;  5CHV A;  3N3G A;  1GMY A;  1MEM A;  1KHQ A;  2VHF A;  2YJB A;  4P6E A;  3CBJ A;  5JH3 A;  2VFB A;  2FQ9 A;  4B55 A;  2HHN A;  4GUZ A;  1EWM A;  1QDQ A;  3IUT A;  1NPZ A;  3C9E A;  1BP4 A;  4FIP A;  1ICF A;  1F29 A;  2F1G A;  4OEL A;  1QMY A;  3B79 A;  5J94 A;  1F2A A;  1U9V A;  3WXE A;  2OUL A;  3KSE A;  2CIO A;  4ZUX U;  2DC7 A;  5A24 A;  5CVN B;  1KHP A;  3I3T A;  2Y5B A;  3KFQ A;  2PRE A;  4W5B A;  2NQD B;  1QOL A;  2DZZ A;  4YYU A;  2DCC A;  3GCB A;  2F7D A;  2G6D A;  4KLB A;  4DMX A;  3MHH A;  9PAP A;  4NV7 A;  1YK8 A;  8PCH A;  4K7C A;  2PAD A;  3H8B A;  3K24 A;  2E02 A;  1EWL A;  1S4V A;  2DJG B;  2NQA A;  2E03 A;  1ME3 A;  4CDD B;  4RY2 A;  1VJV A;  1HUC B;  1QXP A;  3RVX A;  1PPO A;  2FRQ A;  1A6R A;  2E01 A;  2HH5 A;  4YYQ A;  1KFX L;  2VHS A;  1ATK A;  1NL6 A;  3LXS A;  2DC8 A;  5K16 A;  3D6S A;  2GHU A;  1YT7 A;  4AXM A;  4N79 A;  5CVO B;  1PPP A;  4YV8 A;  1MIR A;  3OIS A;  2AYO A;  3QSD A;  3D9W A;  3OF8 A;  2R6N A;  4HWY A;  3H6S A;  2NQG A;  3ERV A;  4XR7 A;  3HHI A;  1CQD A;  3N3K A;  2IBI A;  4I04 A;  3KWB X;  3IOQ A;  1PBH A;  4AXL A;  3USV A;  7PCK A;  4N8W A;  4P6G A;  1EF7 A;  2VFC A;  2AUZ A;  2DC9 A;  3E1Z B;  1KXR A;  4X6H A;  1GX3 A;  3P5V A;  4BS5 A;  3DF0 A;  1U5I A;  3BCN A;  3PDF A;  4WA6 A;  3S3R A;  3K8U A;  2R9F A;  1PPD A;  3MTN A;  2OZ2 A;  1PAD A;  3WXG A;  2FRA A;  2BSZ A;  1SP4 B;  1U9Q X;  1NQC A;  1K3B B;  2ARY A;  1IWD A;  3BOW A;  1Q6K A;  2B1M A;  2HXZ A;  4MZO A;  1PPN A;  3CBK A;  1F2B A;  3LFY A;  3PNR A;  1DEU A;  3KWZ A;  2JQF R;  3I06 A;  2FTD A;  2WBF X;  3KKU A;  4QRV A;  1TU6 A;  1CJL A;  4X6J A;  2B1N A;  2JQG R;  1CV8 A;  5CHT A;  1E2T A;  3O1G A;  1W4T A;  3BC3 A;  3HWN A;  3IMA A;  2PNS A;  1M6D A;  2C0Y A;  1JQP A;  1TL9 A;  2DZY A;  2P86 A;  4G54 A;  4BPV A;  5CVM A;  1AIM A;  4I05 A;  4PAD A;  4QRG A;  4YYR A;  1CTE A;  2OP3 A;  4C5P A;  1ZCM A;  3RVW A;  4YVA A;  3RVV A;  3P5X A;  3QT4 A;  1POP A;  3QJ3 A;  3V6C A;  1CVZ A;  1GCB A;  1YVB A;  3IHP A;  4FJC A;  5F02 A;  1DF0 A;  2FYE A;  3PBH A;  3CH2 X;  4PP1 A;  1PCI A;  6PAD A;  1Y08 A;  1ITO A;  1PIP A;  2AU1 A;  4MSX A;  2G8E A;  2R9M A;  3OVX A;  1MS6 A;  2DCA A;  1TLO A;  2XU3 A;  1AYV A;  2AIM A;  2G7Y A;  3H8C A;  2O6X A;  2GFO A;  3MHS A;  5JA7 A;  1ME4 A;  4N4Z A;  3BPF A;  1AYW A;  4CZW A;  2R9N A;  3TNX A;  2YJ8 A;  1YK7 A;  3OVZ A;  3AI8 A;  4BSQ A;  1CSB B;  1CS8 A;  1W6F A;  3M99 A;  2NQI A;  3NHE A;  3MOR A;  1U9W A;  3K9M A;  1BQI A;  4YYW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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