4W5BA

Crystal structure analysis of cruzain with fragment 1 (n-(1h-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
215
structure length
215
Chain Sequence
APAAVDWRARGAVTAVKDQGQCGSSWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease.
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Trypanosoma cruzi
molecule keywords Cruzipain
total genus 72
structure length 215
sequence length 215
chains with identical sequence B, C
ec nomenclature ec 3.4.22.51: Cruzipain.
pdb deposition date 2014-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00112 Peptidase_C1 Papain family cysteine protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.10 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cysteine proteinases 4w5bA00
1FH0A 1KHPA 4ZUXU 4QH6A 3P5WA 2FT2A 1ME4A 2XU3A 3O0UA 2DJGB 2AS8A 2CIOA 1TU6A 1PPOA 2NQGA 3DF0A 3P5XA 3N4CA 3HD3A 1CB5A 3PDFA 1MEGA 1SP4B 2NQDB 2R9MA 5CVOB 1EWOA 1TLOA 2AYNA 3RVXA 2VHSA 3RVVA 1ITOA 4QBBA 2XU5A 3AI8A 3CH2X 3IMAA 2AUXA 1M6DA 1MEMA 3QSDA 4YYQA 3N3GA 3LXSA 1STFE 1QDQA 2E02A 2FRAA 5K16A 1MHWA 1BQIA 1POPA 1NLJA 1F2BA 1PBHA 1XKGA 2R9NA 3QJ3A 2YJCA 4PI3A 1ATKA 2OP3A 4OELA 2DCCA 1EWMA 2NQAA 3LFYA 2FUDA 1PXVA 1BP4A 2CB5A 2ARYA 1Q6KA 3CBKA 3OF9A 1F2CA 1YVBA 2AUZA 4YYSA 4YYRA 1Y4HA 5EGWA 1U9QX 1YK8A 1CS8A 1AYUA 3IEJA 3MHHA 3OF8A 1NB3A 3I3TA 2YJBA 2DCAA 4AXLA 2FTDA 4CDCB 4FK5A 1KFXL 1QMYA 1CV8A 3N3KA 4G54A 4FIPA 3H7DA 1AYVA 4P6EA 1TL9A 4I07A 1U9XA 1BGOA 1PE6A 5J94A 3PW3A 1K3BB 4AXMA 2H7JA 1ZCMA 3NHEA 1EF7A 2DC7A 2B1NA 3H6SA 2FRQA 1MS6A 2ATOA 3U8EA 1GMYA 4CDFB 4I05A 3HWNA 2DC9A 2HXZA 4BS6A 2R9CA 3MORA 3BWKA 2PADA 1A6RA 2YJ9A 4QRGA 2AYOA 3H89A 2DJFB 2IBIA 5FPWA 3KWZA 2G8EA 4YYVA 2WBFX 1GECE 2OULA 1MDWA 3K24A 2G6DA 1NQCA 1PCIA 3K8UA 1YT7A 4PP1A 2PREA 1CSBB 4BS5A 2C0YA 2HH5A 3P5UA 3QT4A 2PBHA 4QRVA 1CTEA 1AU0A 2XU1A 3BPFA 4MZSA 3KKUA 3MTNA 3KWBX 3P5VA 2FO5A 1Y08A 2DCDA 5PADA 4DMXA 3E1ZB 1ME3A 1AYWA 2JQFR 4YYWA 3GCBA 1NPZA 2F1GA 2AVWA 1O0EA 3TNXA 2BDZA 2AU1A 2PNSA 4PADA 7PCKA 1U9WA 2GHUA 2E01A 2JQGR 1EWLA 2O6XA 1CVZA 1GLOA 1S4VA 4I04A 4CZWA 3B79A 1KXRA 1AIMA 9PAPA 3KX1A 4N4ZA 3KW9A 2YJ8A 4MZOA 3CBJA 3ERVA 8PCHA 1F29A 1THEA 3WXGA 1SNKA 3CH3X 2IPPB 5JA7A 3ZUAA 4CDDB 2B1MA 5EF4A 1U9VA 2BDLA 3OVZA 1ZIVA 3H8CA 5JH3A 1JQPA 2P86A 4OEMA 4KLBA 4Q8GA 2Y5BA 3K9MA 2Y6EA 1VJVA 1YK7A 4W5CA 3I06A 3O1GA 1YALA 2NQIA 4XUIA 1EWPA 1PPNA 2DC6A 4P6GA 3M99A 1QOLA 1AECA 1AU4A 3IV2A 1PPDA 2OZ2A 1U5IA 3C9EA 3OVXA 2HD5A 3F5VA 1ICFA 3PNRA 4W4UA 4XR7A 1F2AA 3S3QA 3HHAA 3RVWA 4BPVA 2R6NA 4N8WA 1HUCB 3F75A 2FQ9A 6PADA 2ACTA 3BOWA 2DZZA 2R9OA 1X9YA 5CHTA 2YJ2A 2FYEA 3HHIA 4X6IA 3MHSA 3KFQA 5CVNB 4Q8HA 1NB5A 3S3RA 4HWYA 4X6JA 3BPMA 4N79A 2AIMA 3IHPA 1IWDA 1DF0A 1NL6A 1QXPA 4MSXA 4BSQA 4RY2A 4X6HA 1PIPA 1PPPA 4PP2E 3PBHA 2DCBA 1KHQA 5CHVA 2VHFA 2DZYA 2E00A 4WA6A 1KFUL 3WXEA 2HHNA 4YV8A 2E03A 3KSEA 4BQVA 3V6EA 1AU2A 4K7CA 4QRXA 2G8JA 1CQDA 3IOQA 3OISA 4FJCA 1MIRA 3BCNA 2P0RA 1VSNA 4YVAA 2DC8A 3V6CA 2F7DA 1PADA 3WXFA 4CDEB 4YYUA 5F02A 3D6SA 3IUTA 1AU3A 2G7YA 2P7UA 1GCBA 5A24A 1CPJA 4DMYA 2R9FA 5CVMA 2XU4A 1DEUA 2GFOA 1CJLA 3USVA 4W5BA 1BY8A 3H8BA 3BC3A
chains in the Genus database with same CATH superfamily
1FH0A 4MI7A 1KHPA 4ZUXU 4QH6A 3P5WA 2FT2A 1ME4A 2XU3A 3O0UA 2DJGB 2AS8A 2CIOA 4XZXA 5KO3A 1TU6A 3RNVA 1PPOA 2NQGA 3DF0A 3P5XA 3N4CA 3HD3A 1CB5A 3PDFA 1MEGA 1SP4B 2NQDB 2R9MA 3ZNHA 4OW0A 5CVOB 1EWOA 1TLOA 2AYNA 3RVXA 2VHSA 3RVVA 1ITOA 4QBBA 2XU5A 3AI8A 3CH2X 3IMAA 2AUXA 1M6DA 1MEMA 3QSDA 4YYQA 3N3GA 3LXSA 4M0WA 4ZTBA 1STFE 1QDQA 2E02A 2FRAA 5K16A 1MHWA 1BQIA 1POPA 1NLJA 3PSEA 5EZSA 1F2BA 5JZEA 1PBHA 1UKFA 3B21A 1XKGA 2R9NA 3QJ3A 4P16A 2YJCA 4PI3A 1ATKA 2OP3A 4OELA 2DCCA 1EWMA 2NQAA 3LFYA 2FUDA 4D8EA 1PXVA 1BP4A 2CB5A 2ARYA 4BOZA 1Q6KA 3CBKA 4BOUA 3OF9A 1F2CA 1YVBA 4BOSA 2AUZA 4YYSA 4YYRA 1Y4HA 1YZBA 4BOQA 5EGWA 1U9QX 4MM3B 1DKIA 1YK8A 3TMPA 2JTCA 1CS8A 1AYUA 3IEJA 3BB7A 3MHHA 4IUMA 3OF8A 4BOPA 1NB3A 3I3TA 2YJBA 2DCAA 4AXLA 2FTDA 4CDCB 4FK5A 1KFXL 1QMYA 1CV8A 3N3KA 4G54A 4FIPA 4RKXA 3H7DA 1AYVA 4P6EA 1TL9A 4I07A 4OVZA 1U9XA 2FE8A 1BGOA 1PE6A 5J94A 3PW3A 1K3BB 4AXMA 3PHXA 2H7JA 1ZCMA 3NHEA 1EF7A 2DC7A 2B1NA 3H6SA 4REZA 2FRQA 3PRMA 1MS6A 2JRIA 3PHWA 5E6JA 4RNAA 2ATOA 3U8EA 1GMYA 4CDFB 4I05A 3HWNA 2DC9A 2HXZA 4BS6A 2R9CA 3MORA 3BWKA 2PADA 1A6RA 2YJ9A 5EZQA 4QRGA 3PHUA 2AYOA 3H89A 2DJFB 2HWKA 2IBIA 5FPWA 3KWZA 2G8EA 4YYVA 2WBFX 1GECE 4RF0A 2BU3A 2OULA 1MDWA 3K24A 2UZJA 2G6DA 3W31A 1NQCA 1PCIA 3K8UA 1YT7A 4PP1A 2PREA 1CSBB 4BS5A 2C0YA 2HH5A 3P5UA 3QT4A 4WURA 2PBHA 4QRVA 1CTEA 1AU0A 3OQCA 2XU1A 3BPFA 4MZSA 4IP3A 3KKUA 3MTNA 3KWBX 3P5VA 3PT2A 2FO5A 1Y08A 2DCDA 5PADA 4DMXA 3E1ZB 1ME3A 1AYWA 2JQFR 4YYWA 3GCBA 1PVJA 1NPZA 4PT5A 2F1GA 2AVWA 1O0EA 3TNXA 3W30A 2BDZA 2AU1A 2PNSA 4PADA 7PCKA 4GUAA 1U9WA 2GHUA 2E01A 4OVZB 4D8IA 2JQGR 1EWLA 2O6XA 1CVZA 1GLOA 1S4VA 4I04A 4CZWA 3B79A 1KXRA 4HXDB 1AIMA 9PAPA 3KX1A 4N4ZA 3KW9A 2YJ8A 4MZOA 2DOSA 3CBJA 2J7QC 3ERVA 3BBAA 8PCHA 1F29A 1THEA 3WXGA 1SNKA 3TRKA 3CH3X 2J7QA 2IPPB 5JA7A 3ZUAA 4CDDB 2B1MA 5EF4A 1U9VA 2BDLA 4RF1A 3OVZA 1ZIVA 3H8CA 5JH3A 1JQPA 2P86A 4OEMA 4KLBA 4Q8GA 2Y5BA 3K9MA 2Y6EA 1VJVA 1YK7A 4W5CA 3I06A 3O1GA 1YALA 2NQIA 3O65A 4XUIA 1EWPA 1PPNA 2DC6A 4P6GA 3M99A 1QOLA 1AECA 1AU4A 3IV2A 1PPDA 2OZ2A 1U5IA 3C9EA 3OVXA 2HD5A 4R3DA 3F5VA 1ICFA 3PNRA 4W4UA 4XR7A 3BY4A 1F2AA 3S3QA 3HHAA 3RVWA 4BPVA 3MTVA 2R6NA 4N8WA 1HUCB 3F75A 3PRPA 2FQ9A 6PADA 2ACTA 3BOWA 2DZZA 2R9OA 1X9YA 5CHTA 2YJ2A 2FYEA 3C0RA 3HHIA 4X6IA 3MP2A 3MHSA 3KFQA 3IFUA 5CVNB 4Q8HA 3S3RA 1NB5A 4HWYA 4X6JA 3MJ5A 3BPMA 4N79A 2AIMA 3IHPA 1IWDA 1DF0A 1NL6A 1QXPA 4MSXA 4BSQA 4RY2A 4X6HA 1PIPA 1PPPA 4PP2E 3PBHA 4A5UA 3E9SA 2DCBA 1KHQA 2BTWB 5CHVA 2VHFA 2DZYA 2E00A 4WA6A 1KFUL 3WXEA 2HHNA 4YV8A 2E03A 3KSEA 4BQVA 3V6EA 1AU2A 4K7CA 4QRXA 2G8JA 1CQDA 3IOQA 2BTWA 4D8BA 3OISA 4FJCA 1MIRA 3BCNA 2P0RA 1VSNA 4YVAA 2DC8A 3V6CA 2F7DA 1PADA 3WXFA 4CDEB 4YYUA 5F02A 3D6SA 3IUTA 1AU3A 2G7YA 2P7UA 1GCBA 5A24A 1CPJA 4DMYA 2R9FA 5CVMA 2XU4A 1DEUA 2GFOA 2Z84A 1CJLA 3USVA 2AGAA 4W5BA 1BY8A 3H8BA 3BC3A
chains in the Genus database with same CATH topology
1FH0A 1KHPA 4ZUXU 4QH6A 3P5WA 2FT2A 1ME4A 2XU3A 3O0UA 2DJGB 2AS8A 2CIOA 1TU6A 1PPOA 2NQGA 3DF0A 3P5XA 3N4CA 3HD3A 1CB5A 3PDFA 1MEGA 1SP4B 2NQDB 2R9MA 5CVOB 1EWOA 1TLOA 2AYNA 3RVXA 2VHSA 3RVVA 1ITOA 4QBBA 2XU5A 3AI8A 3CH2X 3IMAA 2AUXA 1M6DA 1MEMA 3QSDA 4B55A 4YYQA 3N3GA 3LXSA 1STFE 1QDQA 2E02A 2FRAA 5K16A 1MHWA 1BQIA 1POPA 1NLJA 1F2BA 1PBHA 1GX3A 1XKGA 2R9NA 3QJ3A 2YJCA 4PI3A 1ATKA 2OP3A 4OELA 2DCCA 1EWMA 2NQAA 3LFYA 2FUDA 1PXVA 1BP4A 2CB5A 2ARYA 1Q6KA 3CBKA 3OF9A 1F2CA 1YVBA 2AUZA 4YYSA 4YYRA 1Y4HA 5EGWA 1U9QX 1YK8A 2VFBA 1CS8A 1AYUA 3IEJA 3MHHA 3OF8A 1NB3A 3I3TA 2YJBA 2DCAA 4AXLA 2FTDA 4CDCB 4FK5A 1KFXL 1QMYA 1CV8A 4NV8A 3N3KA 4G54A 4FIPA 3H7DA 1AYVA 4P6EA 1TL9A 4I07A 1E2TA 1U9XA 1BGOA 1PE6A 5J94A 2BSZA 3PW3A 1K3BB 4AXMA 4GUZA 2H7JA 1ZCMA 3NHEA 1EF7A 2DC7A 2B1NA 3H6SA 2FRQA 1MS6A 2ATOA 3U8EA 3D9WA 1GMYA 4CDFB 4I05A 3HWNA 2DC9A 2HXZA 4BS6A 2R9CA 3MORA 3BWKA 2PADA 1A6RA 2YJ9A 4QRGA 2AYOA 3H89A 2DJFB 2IBIA 5FPWA 3KWZA 2G8EA 4YYVA 2WBFX 1GECE 2OULA 4BGFA 1MDWA 3K24A 2G6DA 1NQCA 1PCIA 3K8UA 1YT7A 4PP1A 2PREA 1CSBB 4BS5A 2C0YA 2HH5A 3P5UA 3QT4A 2PBHA 4QRVA 1CTEA 1AU0A 2XU1A 3BPFA 4MZSA 3KKUA 3MTNA 3KWBX 3P5VA 2FO5A 1Y08A 2DCDA 5PADA 4DMXA 3E1ZB 1ME3A 1AYWA 2JQFR 4YYWA 3GCBA 1NPZA 2F1GA 2AVWA 1O0EA 3TNXA 2BDZA 2AU1A 2PNSA 4PADA 7PCKA 1U9WA 2GHUA 2E01A 2JQGR 1W4TA 1EWLA 2O6XA 1CVZA 1GLOA 1S4VA 4I04A 4CZWA 3B79A 1KXRA 1AIMA 9PAPA 2VFCA 3KX1A 4N4ZA 3KW9A 2YJ8A 4MZOA 3CBJA 3ERVA 8PCHA 1F29A 1THEA 3WXGA 1SNKA 3CH3X 2IPPB 1W5RA 5JA7A 3ZUAA 4CDDB 2B1MA 5EF4A 1U9VA 2BDLA 3OVZA 1ZIVA 3H8CA 5JH3A 1JQPA 2P86A 4OEMA 4KLBA 4Q8GA 2Y5BA 3K9MA 2Y6EA 1VJVA 1YK7A 4W5CA 3I06A 3O1GA 1YALA 2NQIA 4XUIA 1EWPA 1PPNA 2DC6A 4P6GA 3M99A 1QOLA 1AECA 1AU4A 3IV2A 1PPDA 2OZ2A 1U5IA 3C9EA 3OVXA 2HD5A 3F5VA 1ICFA 3PNRA 4W4UA 4XR7A 1F2AA 3S3QA 3HHAA 3RVWA 4BPVA 2R6NA 4N8WA 1HUCB 3F75A 3LTWA 2FQ9A 6PADA 2ACTA 3BOWA 2DZZA 2R9OA 1X9YA 5CHTA 2YJ2A 2FYEA 3HHIA 4X6IA 3MHSA 3KFQA 5CVNB 4Q8HA 1NB5A 3S3RA 4HWYA 4X6JA 3BPMA 4N79A 2AIMA 3IHPA 1IWDA 1DF0A 1NL6A 1QXPA 4MSXA 4BSQA 4RY2A 4X6HA 1PIPA 1PPPA 4PP2E 3PBHA 2DCBA 1W6FA 1KHQA 5CHVA 2VHFA 2DZYA 2E00A 4WA6A 1KFUL 3WXEA 2HHNA 4YV8A 2E03A 4C5PA 3KSEA 4BQVA 3V6EA 1AU2A 4K7CA 4QRXA 2G8JA 1CQDA 3IOQA 3OISA 4FJCA 1MIRA 3BCNA 2P0RA 1VSNA 4YVAA 2DC8A 3V6CA 2F7DA 1PADA 3WXFA 4NV7A 4CDEB 4YYUA 5F02A 3D6SA 3IUTA 1AU3A 2G7YA 2P7UA 1GCBA 5A24A 1CPJA 4DMYA 2R9FA 5CVMA 2XU4A 1DEUA 2GFOA 1CJLA 3USVA 4W5BA 1BY8A 3H8BA 3BC3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FH0 A;  1KHP A;  4ZUX U;  4QH6 A;  3P5W A;  2FT2 A;  1ME4 A;  2XU3 A;  3O0U A;  2DJG B;  2AS8 A;  2CIO A;  1TU6 A;  1PPO A;  2NQG A;  3DF0 A;  3P5X A;  3N4C A;  3HD3 A;  1CB5 A;  3PDF A;  1MEG A;  1SP4 B;  2NQD B;  2R9M A;  5CVO B;  1EWO A;  1TLO A;  2AYN A;  3RVX A;  2VHS A;  3RVV A;  1ITO A;  4QBB A;  2XU5 A;  3AI8 A;  3CH2 X;  3IMA A;  2AUX A;  1M6D A;  1MEM A;  3QSD A;  4YYQ A;  3N3G A;  3LXS A;  1STF E;  1QDQ A;  2E02 A;  2FRA A;  5K16 A;  1MHW A;  1BQI A;  1POP A;  1NLJ A;  1F2B A;  1PBH A;  1XKG A;  2R9N A;  3QJ3 A;  2YJC A;  4PI3 A;  1ATK A;  2OP3 A;  4OEL A;  2DCC A;  1EWM A;  2NQA A;  3LFY A;  2FUD A;  1PXV A;  1BP4 A;  2CB5 A;  2ARY A;  1Q6K A;  3CBK A;  3OF9 A;  1F2C A;  1YVB A;  2AUZ A;  4YYS A;  4YYR A;  1Y4H A;  5EGW A;  1U9Q X;  1YK8 A;  1CS8 A;  1AYU A;  3IEJ A;  3MHH A;  3OF8 A;  1NB3 A;  3I3T A;  2YJB A;  2DCA A;  4AXL A;  2FTD A;  4CDC B;  4FK5 A;  1KFX L;  1QMY A;  1CV8 A;  3N3K A;  4G54 A;  4FIP A;  3H7D A;  1AYV A;  4P6E A;  1TL9 A;  4I07 A;  1U9X A;  1BGO A;  1PE6 A;  5J94 A;  3PW3 A;  1K3B B;  4AXM A;  2H7J A;  1ZCM A;  3NHE A;  1EF7 A;  2DC7 A;  2B1N A;  3H6S A;  2FRQ A;  1MS6 A;  2ATO A;  3U8E A;  1GMY A;  4CDF B;  4I05 A;  3HWN A;  2DC9 A;  2HXZ A;  4BS6 A;  2R9C A;  3MOR A;  3BWK A;  2PAD A;  1A6R A;  2YJ9 A;  4QRG A;  2AYO A;  3H89 A;  2DJF B;  2IBI A;  5FPW A;  3KWZ A;  2G8E A;  4YYV A;  2WBF X;  1GEC E;  2OUL A;  1MDW A;  3K24 A;  2G6D A;  1NQC A;  1PCI A;  3K8U A;  1YT7 A;  4PP1 A;  2PRE A;  1CSB B;  4BS5 A;  2C0Y A;  2HH5 A;  3P5U A;  3QT4 A;  2PBH A;  4QRV A;  1CTE A;  1AU0 A;  2XU1 A;  3BPF A;  4MZS A;  3KKU A;  3MTN A;  3KWB X;  3P5V A;  2FO5 A;  1Y08 A;  2DCD A;  5PAD A;  4DMX A;  3E1Z B;  1ME3 A;  1AYW A;  2JQF R;  4YYW A;  3GCB A;  1NPZ A;  2F1G A;  2AVW A;  1O0E A;  3TNX A;  2BDZ A;  2AU1 A;  2PNS A;  4PAD A;  7PCK A;  1U9W A;  2GHU A;  2E01 A;  2JQG R;  1EWL A;  2O6X A;  1CVZ A;  1GLO A;  1S4V A;  4I04 A;  4CZW A;  3B79 A;  1KXR A;  1AIM A;  9PAP A;  3KX1 A;  4N4Z A;  3KW9 A;  2YJ8 A;  4MZO A;  3CBJ A;  3ERV A;  8PCH A;  1F29 A;  1THE A;  3WXG A;  1SNK A;  3CH3 X;  2IPP B;  5JA7 A;  3ZUA A;  4CDD B;  2B1M A;  5EF4 A;  1U9V A;  2BDL A;  3OVZ A;  1ZIV A;  3H8C A;  5JH3 A;  1JQP A;  2P86 A;  4OEM A;  4KLB A;  4Q8G A;  2Y5B A;  3K9M A;  2Y6E A;  1VJV A;  1YK7 A;  4W5C A;  3I06 A;  3O1G A;  1YAL A;  2NQI A;  4XUI A;  1EWP A;  1PPN A;  2DC6 A;  4P6G A;  3M99 A;  1QOL A;  1AEC A;  1AU4 A;  3IV2 A;  1PPD A;  2OZ2 A;  1U5I A;  3C9E A;  3OVX A;  2HD5 A;  3F5V A;  1ICF A;  3PNR A;  4W4U A;  4XR7 A;  1F2A A;  3S3Q A;  3HHA A;  3RVW A;  4BPV A;  2R6N A;  4N8W A;  1HUC B;  3F75 A;  2FQ9 A;  6PAD A;  2ACT A;  3BOW A;  2DZZ A;  2R9O A;  1X9Y A;  5CHT A;  2YJ2 A;  2FYE A;  3HHI A;  4X6I A;  3MHS A;  3KFQ A;  5CVN B;  4Q8H A;  1NB5 A;  3S3R A;  4HWY A;  4X6J A;  3BPM A;  4N79 A;  2AIM A;  3IHP A;  1IWD A;  1DF0 A;  1NL6 A;  1QXP A;  4MSX A;  4BSQ A;  4RY2 A;  4X6H A;  1PIP A;  1PPP A;  4PP2 E;  3PBH A;  2DCB A;  1KHQ A;  5CHV A;  2VHF A;  2DZY A;  2E00 A;  4WA6 A;  1KFU L;  3WXE A;  2HHN A;  4YV8 A;  2E03 A;  3KSE A;  4BQV A;  3V6E A;  1AU2 A;  4K7C A;  4QRX A;  2G8J A;  1CQD A;  3IOQ A;  3OIS A;  4FJC A;  1MIR A;  3BCN A;  2P0R A;  1VSN A;  4YVA A;  2DC8 A;  3V6C A;  2F7D A;  1PAD A;  3WXF A;  4CDE B;  4YYU A;  5F02 A;  3D6S A;  3IUT A;  1AU3 A;  2G7Y A;  2P7U A;  1GCB A;  5A24 A;  1CPJ A;  4DMY A;  2R9F A;  5CVM A;  2XU4 A;  1DEU A;  2GFO A;  1CJL A;  3USV A;  4W5B A;  1BY8 A;  3H8B A;  3BC3 A; 
#chains in the Genus database with same CATH topology
 1FH0 A;  4MI7 A;  1KHP A;  4ZUX U;  4QH6 A;  3P5W A;  2FT2 A;  1ME4 A;  2XU3 A;  3O0U A;  2DJG B;  2AS8 A;  2CIO A;  4XZX A;  5KO3 A;  1TU6 A;  3RNV A;  1PPO A;  2NQG A;  3DF0 A;  3P5X A;  3N4C A;  3HD3 A;  1CB5 A;  3PDF A;  1MEG A;  1SP4 B;  2NQD B;  2R9M A;  3ZNH A;  4OW0 A;  5CVO B;  1EWO A;  1TLO A;  2AYN A;  3RVX A;  2VHS A;  3RVV A;  1ITO A;  4QBB A;  2XU5 A;  3AI8 A;  3CH2 X;  3IMA A;  2AUX A;  1M6D A;  1MEM A;  3QSD A;  4YYQ A;  3N3G A;  3LXS A;  4M0W A;  4ZTB A;  1STF E;  1QDQ A;  2E02 A;  2FRA A;  5K16 A;  1MHW A;  1BQI A;  1POP A;  1NLJ A;  3PSE A;  5EZS A;  1F2B A;  5JZE A;  1PBH A;  1UKF A;  3B21 A;  1XKG A;  2R9N A;  3QJ3 A;  4P16 A;  2YJC A;  4PI3 A;  1ATK A;  2OP3 A;  4OEL A;  2DCC A;  1EWM A;  2NQA A;  3LFY A;  2FUD A;  4D8E A;  1PXV A;  1BP4 A;  2CB5 A;  2ARY A;  4BOZ A;  1Q6K A;  3CBK A;  4BOU A;  3OF9 A;  1F2C A;  1YVB A;  4BOS A;  2AUZ A;  4YYS A;  4YYR A;  1Y4H A;  1YZB A;  4BOQ A;  5EGW A;  1U9Q X;  4MM3 B;  1DKI A;  1YK8 A;  3TMP A;  2JTC A;  1CS8 A;  1AYU A;  3IEJ A;  3BB7 A;  3MHH A;  4IUM A;  3OF8 A;  4BOP A;  1NB3 A;  3I3T A;  2YJB A;  2DCA A;  4AXL A;  2FTD A;  4CDC B;  4FK5 A;  1KFX L;  1QMY A;  1CV8 A;  3N3K A;  4G54 A;  4FIP A;  4RKX A;  3H7D A;  1AYV A;  4P6E A;  1TL9 A;  4I07 A;  4OVZ A;  1U9X A;  2FE8 A;  1BGO A;  1PE6 A;  5J94 A;  3PW3 A;  1K3B B;  4AXM A;  3PHX A;  2H7J A;  1ZCM A;  3NHE A;  1EF7 A;  2DC7 A;  2B1N A;  3H6S A;  4REZ A;  2FRQ A;  3PRM A;  1MS6 A;  2JRI A;  3PHW A;  5E6J A;  4RNA A;  2ATO A;  3U8E A;  1GMY A;  4CDF B;  4I05 A;  3HWN A;  2DC9 A;  2HXZ A;  4BS6 A;  2R9C A;  3MOR A;  3BWK A;  2PAD A;  1A6R A;  2YJ9 A;  5EZQ A;  4QRG A;  3PHU A;  2AYO A;  3H89 A;  2DJF B;  2HWK A;  2IBI A;  5FPW A;  3KWZ A;  2G8E A;  4YYV A;  2WBF X;  1GEC E;  4RF0 A;  2BU3 A;  2OUL A;  1MDW A;  3K24 A;  2UZJ A;  2G6D A;  3W31 A;  1NQC A;  1PCI A;  3K8U A;  1YT7 A;  4PP1 A;  2PRE A;  1CSB B;  4BS5 A;  2C0Y A;  2HH5 A;  3P5U A;  3QT4 A;  4WUR A;  2PBH A;  4QRV A;  1CTE A;  1AU0 A;  3OQC A;  2XU1 A;  3BPF A;  4MZS A;  4IP3 A;  3KKU A;  3MTN A;  3KWB X;  3P5V A;  3PT2 A;  2FO5 A;  1Y08 A;  2DCD A;  5PAD A;  4DMX A;  3E1Z B;  1ME3 A;  1AYW A;  2JQF R;  4YYW A;  3GCB A;  1PVJ A;  1NPZ A;  4PT5 A;  2F1G A;  2AVW A;  1O0E A;  3TNX A;  3W30 A;  2BDZ A;  2AU1 A;  2PNS A;  4PAD A;  7PCK A;  4GUA A;  1U9W A;  2GHU A;  2E01 A;  4OVZ B;  4D8I A;  2JQG R;  1EWL A;  2O6X A;  1CVZ A;  1GLO A;  1S4V A;  4I04 A;  4CZW A;  3B79 A;  1KXR A;  4HXD B;  1AIM A;  9PAP A;  3KX1 A;  4N4Z A;  3KW9 A;  2YJ8 A;  4MZO A;  2DOS A;  3CBJ A;  2J7Q C;  3ERV A;  3BBA A;  8PCH A;  1F29 A;  1THE A;  3WXG A;  1SNK A;  3TRK A;  3CH3 X;  2J7Q A;  2IPP B;  5JA7 A;  3ZUA A;  4CDD B;  2B1M A;  5EF4 A;  1U9V A;  2BDL A;  4RF1 A;  3OVZ A;  1ZIV A;  3H8C A;  5JH3 A;  1JQP A;  2P86 A;  4OEM A;  4KLB A;  4Q8G A;  2Y5B A;  3K9M A;  2Y6E A;  1VJV A;  1YK7 A;  4W5C A;  3I06 A;  3O1G A;  1YAL A;  2NQI A;  3O65 A;  4XUI A;  1EWP A;  1PPN A;  2DC6 A;  4P6G A;  3M99 A;  1QOL A;  1AEC A;  1AU4 A;  3IV2 A;  1PPD A;  2OZ2 A;  1U5I A;  3C9E A;  3OVX A;  2HD5 A;  4R3D A;  3F5V A;  1ICF A;  3PNR A;  4W4U A;  4XR7 A;  3BY4 A;  1F2A A;  3S3Q A;  3HHA A;  3RVW A;  4BPV A;  3MTV A;  2R6N A;  4N8W A;  1HUC B;  3F75 A;  3PRP A;  2FQ9 A;  6PAD A;  2ACT A;  3BOW A;  2DZZ A;  2R9O A;  1X9Y A;  5CHT A;  2YJ2 A;  2FYE A;  3C0R A;  3HHI A;  4X6I A;  3MP2 A;  3MHS A;  3KFQ A;  3IFU A;  5CVN B;  4Q8H A;  3S3R A;  1NB5 A;  4HWY A;  4X6J A;  3MJ5 A;  3BPM A;  4N79 A;  2AIM A;  3IHP A;  1IWD A;  1DF0 A;  1NL6 A;  1QXP A;  4MSX A;  4BSQ A;  4RY2 A;  4X6H A;  1PIP A;  1PPP A;  4PP2 E;  3PBH A;  4A5U A;  3E9S A;  2DCB A;  1KHQ A;  2BTW B;  5CHV A;  2VHF A;  2DZY A;  2E00 A;  4WA6 A;  1KFU L;  3WXE A;  2HHN A;  4YV8 A;  2E03 A;  3KSE A;  4BQV A;  3V6E A;  1AU2 A;  4K7C A;  4QRX A;  2G8J A;  1CQD A;  3IOQ A;  2BTW A;  4D8B A;  3OIS A;  4FJC A;  1MIR A;  3BCN A;  2P0R A;  1VSN A;  4YVA A;  2DC8 A;  3V6C A;  2F7D A;  1PAD A;  3WXF A;  4CDE B;  4YYU A;  5F02 A;  3D6S A;  3IUT A;  1AU3 A;  2G7Y A;  2P7U A;  1GCB A;  5A24 A;  1CPJ A;  4DMY A;  2R9F A;  5CVM A;  2XU4 A;  1DEU A;  2GFO A;  2Z84 A;  1CJL A;  3USV A;  2AGA A;  4W5B A;  1BY8 A;  3H8B A;  3BC3 A; 
#chains in the Genus database with same CATH homology
 1FH0 A;  1KHP A;  4ZUX U;  4QH6 A;  3P5W A;  2FT2 A;  1ME4 A;  2XU3 A;  3O0U A;  2DJG B;  2AS8 A;  2CIO A;  1TU6 A;  1PPO A;  2NQG A;  3DF0 A;  3P5X A;  3N4C A;  3HD3 A;  1CB5 A;  3PDF A;  1MEG A;  1SP4 B;  2NQD B;  2R9M A;  5CVO B;  1EWO A;  1TLO A;  2AYN A;  3RVX A;  2VHS A;  3RVV A;  1ITO A;  4QBB A;  2XU5 A;  3AI8 A;  3CH2 X;  3IMA A;  2AUX A;  1M6D A;  1MEM A;  3QSD A;  4B55 A;  4YYQ A;  3N3G A;  3LXS A;  1STF E;  1QDQ A;  2E02 A;  2FRA A;  5K16 A;  1MHW A;  1BQI A;  1POP A;  1NLJ A;  1F2B A;  1PBH A;  1GX3 A;  1XKG A;  2R9N A;  3QJ3 A;  2YJC A;  4PI3 A;  1ATK A;  2OP3 A;  4OEL A;  2DCC A;  1EWM A;  2NQA A;  3LFY A;  2FUD A;  1PXV A;  1BP4 A;  2CB5 A;  2ARY A;  1Q6K A;  3CBK A;  3OF9 A;  1F2C A;  1YVB A;  2AUZ A;  4YYS A;  4YYR A;  1Y4H A;  5EGW A;  1U9Q X;  1YK8 A;  2VFB A;  1CS8 A;  1AYU A;  3IEJ A;  3MHH A;  3OF8 A;  1NB3 A;  3I3T A;  2YJB A;  2DCA A;  4AXL A;  2FTD A;  4CDC B;  4FK5 A;  1KFX L;  1QMY A;  1CV8 A;  4NV8 A;  3N3K A;  4G54 A;  4FIP A;  3H7D A;  1AYV A;  4P6E A;  1TL9 A;  4I07 A;  1E2T A;  1U9X A;  1BGO A;  1PE6 A;  5J94 A;  2BSZ A;  3PW3 A;  1K3B B;  4AXM A;  4GUZ A;  2H7J A;  1ZCM A;  3NHE A;  1EF7 A;  2DC7 A;  2B1N A;  3H6S A;  2FRQ A;  1MS6 A;  2ATO A;  3U8E A;  3D9W A;  1GMY A;  4CDF B;  4I05 A;  3HWN A;  2DC9 A;  2HXZ A;  4BS6 A;  2R9C A;  3MOR A;  3BWK A;  2PAD A;  1A6R A;  2YJ9 A;  4QRG A;  2AYO A;  3H89 A;  2DJF B;  2IBI A;  5FPW A;  3KWZ A;  2G8E A;  4YYV A;  2WBF X;  1GEC E;  2OUL A;  4BGF A;  1MDW A;  3K24 A;  2G6D A;  1NQC A;  1PCI A;  3K8U A;  1YT7 A;  4PP1 A;  2PRE A;  1CSB B;  4BS5 A;  2C0Y A;  2HH5 A;  3P5U A;  3QT4 A;  2PBH A;  4QRV A;  1CTE A;  1AU0 A;  2XU1 A;  3BPF A;  4MZS A;  3KKU A;  3MTN A;  3KWB X;  3P5V A;  2FO5 A;  1Y08 A;  2DCD A;  5PAD A;  4DMX A;  3E1Z B;  1ME3 A;  1AYW A;  2JQF R;  4YYW A;  3GCB A;  1NPZ A;  2F1G A;  2AVW A;  1O0E A;  3TNX A;  2BDZ A;  2AU1 A;  2PNS A;  4PAD A;  7PCK A;  1U9W A;  2GHU A;  2E01 A;  2JQG R;  1W4T A;  1EWL A;  2O6X A;  1CVZ A;  1GLO A;  1S4V A;  4I04 A;  4CZW A;  3B79 A;  1KXR A;  1AIM A;  9PAP A;  2VFC A;  3KX1 A;  4N4Z A;  3KW9 A;  2YJ8 A;  4MZO A;  3CBJ A;  3ERV A;  8PCH A;  1F29 A;  1THE A;  3WXG A;  1SNK A;  3CH3 X;  2IPP B;  1W5R A;  5JA7 A;  3ZUA A;  4CDD B;  2B1M A;  5EF4 A;  1U9V A;  2BDL A;  3OVZ A;  1ZIV A;  3H8C A;  5JH3 A;  1JQP A;  2P86 A;  4OEM A;  4KLB A;  4Q8G A;  2Y5B A;  3K9M A;  2Y6E A;  1VJV A;  1YK7 A;  4W5C A;  3I06 A;  3O1G A;  1YAL A;  2NQI A;  4XUI A;  1EWP A;  1PPN A;  2DC6 A;  4P6G A;  3M99 A;  1QOL A;  1AEC A;  1AU4 A;  3IV2 A;  1PPD A;  2OZ2 A;  1U5I A;  3C9E A;  3OVX A;  2HD5 A;  3F5V A;  1ICF A;  3PNR A;  4W4U A;  4XR7 A;  1F2A A;  3S3Q A;  3HHA A;  3RVW A;  4BPV A;  2R6N A;  4N8W A;  1HUC B;  3F75 A;  3LTW A;  2FQ9 A;  6PAD A;  2ACT A;  3BOW A;  2DZZ A;  2R9O A;  1X9Y A;  5CHT A;  2YJ2 A;  2FYE A;  3HHI A;  4X6I A;  3MHS A;  3KFQ A;  5CVN B;  4Q8H A;  1NB5 A;  3S3R A;  4HWY A;  4X6J A;  3BPM A;  4N79 A;  2AIM A;  3IHP A;  1IWD A;  1DF0 A;  1NL6 A;  1QXP A;  4MSX A;  4BSQ A;  4RY2 A;  4X6H A;  1PIP A;  1PPP A;  4PP2 E;  3PBH A;  2DCB A;  1W6F A;  1KHQ A;  5CHV A;  2VHF A;  2DZY A;  2E00 A;  4WA6 A;  1KFU L;  3WXE A;  2HHN A;  4YV8 A;  2E03 A;  4C5P A;  3KSE A;  4BQV A;  3V6E A;  1AU2 A;  4K7C A;  4QRX A;  2G8J A;  1CQD A;  3IOQ A;  3OIS A;  4FJC A;  1MIR A;  3BCN A;  2P0R A;  1VSN A;  4YVA A;  2DC8 A;  3V6C A;  2F7D A;  1PAD A;  3WXF A;  4NV7 A;  4CDE B;  4YYU A;  5F02 A;  3D6S A;  3IUT A;  1AU3 A;  2G7Y A;  2P7U A;  1GCB A;  5A24 A;  1CPJ A;  4DMY A;  2R9F A;  5CVM A;  2XU4 A;  1DEU A;  2GFO A;  1CJL A;  3USV A;  4W5B A;  1BY8 A;  3H8B A;  3BC3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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