1YH8A

Crystal structure of aquifex aeolicus lpxc deacetylase complexed with palmitate
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
266
structure length
266
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 86
structure length 266
sequence length 266
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2005-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 1yh8A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 1yh8A02
2VESA 2IESA 1P42A 4J3DA 4FW3A 5DRPA 4LCHA 4OKGA 1YH8A 4FW6A 3NZKA 4FW4A 4LCFA 4OZEA 2JT2A 3P3CA 4U3DA 2O3ZA 3P3EA 4MDTA 2J65A 3P76A 4ISAA 4U3BA 5DRRA 4FW7A 4MQYA 3PS1A 2IERA 5DRQA 2GO3A 4IS9A 4LCGA 1XXEA 3PS2A 4FW5A 1YHCA 3U1YA 3PS3A 3UHMA 2GO4A 5DROA 3P3GA
chains in the Genus database with same CATH superfamily
4DV6I 4KHPI 1Z5CA 1RREA 4JI5E 1XMOI 1N34I 4LCFA 4JI1I 2O1UA 3Q6MA 1ELOA 4LF8I 1RR9A 3L7ZB 1Z0GA 5LMNI 2AJ4A 1IBKI 2R42A 3T1YE 4JI8I 2NN6C 2CZ9A 4YHHE 4B3TI 2VQEI 2IOQA 2C38B 2NN6F 5K36E 4MU0A 4PRVA 5L3JA 5K36C 2C39A 4WUCA 3CDIA 2UUBI 5LMUI 1OYSA 4OX9E 2CGEA 1USVA 4DV0E 2UUCE 4JG4A 2HHHE 2IERA 2E5LE 3U1KA 2BA0D 5ELWA 2PNZB 3PS3A 3L7ZA 4JV5E 4DR2E 1UDQA 4KQVA 4MU1A 2JEAB 2F4VE 5C0XB 1OYPA 4JI7I 4DR5E 2O1VA 4PU9A 3LPSA 3J80Q 1EI1A 4DR1I 3H4LA 1N0VC 2BA0G 5DNXA 4BA1B 2O1WA 1XNRI 3GMEA 4MU4A 4NXMI 4DV7I 4K0KI 2GO4A 2PNZA 3K85A 3J7AG 1HNZE 2UU9E 2JE6B 1EA6A 2UXCI 1XMQE 1H73A 2WP8A 2XEXA 3KRNA 3WU4A 1PIEA 1HNWE 5JEAB 1Z5AA 2F1DA 1HK7A 3P3EA 4FW7A 1PKPA 4B3SE 4JI3I 2PO2B 3WU6A 4DR4E 4X64I 1E3PA 4BA1A 4LCGA 1UDOA 4GKKE 3J81C 1BKNA 1OJ4A 3UHMA 1Z0VA 3LNUA 4LPFA 5DROA 4B3RE 4DXLA 1USUA 2GS8A 2Z5BB 3F0NA 5C0XD 3T1HE 1HR0I 1KTVA 1Y5YA 3DD6A 2HK2A 4DV3I 4LFBI 4IZJA 4DPWA 4LF4E 1YH8A 2UXBI 5IWAE 2NN6A 3B82A 1S4EA 1KIJA 4U3BA 4JI0E 3P76A 1R6LA 3OTOI 1MU5A 4LF9E 4MU3A 4IFDB 1U2RA 4M1KA 3PRYA 2WNRB 4DR7I 5C0XC 4I3HA 3B78A 3P3GA 2ZM6I 1H7SA 2VESA 1Z59A 5C0XF 4DV1I 4YY3I 3ZM7A 1XHKA 2BM1A 5DNLA 5JEAD 2PO0A 4DUYE 3GLLA 2UXDE 3T1YI 2R3VA 2PNMA 4IZKB 3HULA 2UUAE 4ED4A 1H72C 2O3ZA 1I94E 1RHYA 1FJGE 3GCMA 2NN6E 1N33E 2V2VA 4DV2E 1A6FA 2WW4A 4BA2A 2CVEA 4OX9I 2IESA 5JEAC 4DV0I 4DPTA 2Q2EB 1FWLA 4JI2E 4LFAE 4FWDA 2BR2B 1MG7A 5JEAF 1N32I 2BA1D 2A2DA 3QT8A 4KHPE 4OZEA 1KVKA 3P3CA 3M85D 4JV5I 4U3DA 2J65A 3JAMC 4DR3I 4DR2I 1HNXE 4IFDD 4IZKA 2C37B 4X62E 1UEKA 1NHHA 2HKEA 4AIMA 1D6TA 4DR5I 2VQFE 2A2CA 2BV3A 4OO1D 3J7AM 1Z0EA 2V2ZA 2BA1G 4AIDA 4FN5A 1IBKE 4MYUA 2C38A 3M6AA 4JI8E 3M85G 4LCHA 4OKGA 5A2QC 4HACB 3V2UC 4IFDC 1K47A 2HFSA 2V8PA 4JYAI 4NXNI 4LF7I 4IFDF 4X65E 4AQYE 3PS1A 1ZM4A 1J5EI 5EKWA 1HNZI 4DR6E 2UU9I 3GONA 5LMUE 1XMQI 3PYEA 2C37A 1B63A 3LTOA 1N0UA 3ZZTA 4OO1F 4UTGA 1HNWI 1N36I 1P42A 3P06A 1XNQE 4B3SI 4DR4I 2X7IA 4DV4I 4GKKI 2CG9A 4FW4A 1Y4SA 2JT2A 1FWKA 4B3RI 2JEBB 2JEAA 2V34A 4HACA 4FW9A 3HKMA 4R1FA 5C0XA 1ZXMA 4JI6E 2GO3A 4JI7E 2O1TA 3ZZUA 4URLA 3D4JA 4DR1E 4HYMA 4QNKA 1XNRE 4USKA 4LF6E 3PYGA 4PRXA 5FLXC 2EFGA 4JI4E 4DV7E 4J3DA 5A2QQ 1Z0TA 4DUZE 1FNMA 4GKJI 4K0KE 1H7UA 3NZKA 2JE6A 4Z7YA 1VI7A 4LFCE 5IT9C 4ISAA 5DRRA 4X66I 1WUUA 2J7KA 2NPFA 4P7AA 5JEAA 4JI5I 1UDSA 4IS9A 4FW5A 4FWGA 5C0XE 1FI4A 1UDNA 2UXDI 1Y6ZA 2PO2A 2DEIA 2ZBKB 2UUAI 3CDJA 4DPYA 2DEJA 5LL6R 1KKHA 1I94I 1FJGI 1Z0WA 1ZM2A 5FLXQ 4OO1B 1N33I 2Z5BA 5GMEA 4DV2I 4FW6A 4DV5E 4YHHI 1IBME 1HR0E 4HY1A 4LFAI 3J81Q 1IBLE 1ZM3A 2HKJA 3QT7A 5JEAE 3OTOE 4IFDA 2WNRA 5DRPA 1VISA 1HNXI 4LOMA 4XTJA 2UUCI 4X62I 4LF5E 3Q6NA 2HHHI 1Z5BA 4B3ME 5K36D 4QNJA 4DR7E 5EL9A 5BR8E 2E5LI 5IT9Q 2ZM6E 4OO1A 3Q1QA 2VQFI 4DV6E 1OYRA 4DV1E 4YY3E 1XMOE 1N34E 4MQYA 4HXZA 3J80C 2E1RA 3PYDA 3ZKDA 1FKAE 2F4VI 4Z7CA 4JI1E 4ZVIA 4LF8E 3WU5A 3B8HA 4N3OA 1E3HA 4FWHA 2GQ0A 4X65I 4AQYI 1H74A 5LMNE 4DR6I 5K36F 3ZZ0A 4IFDE 4B3TE 2VQEE 2BR2A 1XNQI 4OO1E 5DRQA 1N32E 2UUBE 2LJPA 4OO1C 4GQUA 2PO1B 3M7ND 2BM0A 4DR3E 5GMDA 2HFUA 2WP8B 3ZKBA 4MYTA 1PVGA 1R6MA 2OI2A 1Y60A 4JI6I 5FWKA 2VF3A 4DPXA 3JAMQ 2V2QA 4DU7A 2IOPA 4MDTA 3HJCA 3K17A 4LF6I 4JI4I 3K1JA 3M7NG 4DUZI 1QZRA 3T1HI 4AM3A 1S16A 1Z0BA 4JYAE 3H1CA 4NXNE 3V5RA 2HK3A 4LF4I 4LF7E 5IWAI 1J5EE 4IZJB 4LFCI 4NXME 2PO1A 2AE8A 4WUDA 4JI0I 2NN6B 1NHIA 4LF9I 1ZXNA 3PYFA 4X66E 1N36E 4UT4A 4DU8A 5K36B 4WUBA 2UXCE 2Z5CB 1DARA 4DV4E 1XXEA 2JEBA 3PS2A 1YHCA 1Z0CA 1B62A 2Z5EA 4EMDA 4DUYI 4DV5I 2PO0B 1Y4UA 1MX0A 4RPFA 1IBMI 4JI3E 2PNLA 4FW3A 4X64E 4USMA 2X36A 3QT5A 1IBLI 3CWVA 2ZITA 3QT6A 3WU3A 4BA2B 4GKJE 4P52A 4DV3E 5K36A 4NBQA 4LFBE 4JI2I 3U1YA 4LF5I 1NHJA 4B3MI 2UXBE 4DPUA 5BR8I 1ZM9A 3B4TA 2Z5CA 4IZJD 1NZ0A 2C39B 2NN6D
chains in the Genus database with same CATH topology
2VESA 2IESA 1P42A 4J3DA 4FW3A 5DRPA 4LCHA 4OKGA 1YH8A 4FW6A 3NZKA 4FW4A 4LCFA 4OZEA 2JT2A 3P3CA 4U3DA 2O3ZA 3P3EA 4MDTA 2J65A 3P76A 4ISAA 4U3BA 5DRRA 4FW7A 4MQYA 3PS1A 2IERA 5DRQA 2GO3A 4IS9A 4LCGA 1XXEA 3PS2A 4FW5A 1YHCA 3U1YA 3PS3A 3UHMA 2GO4A 5DROA 3P3GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VES A;  2IES A;  1P42 A;  4J3D A;  4FW3 A;  5DRP A;  4LCH A;  4OKG A;  1YH8 A;  4FW6 A;  3NZK A;  4FW4 A;  4LCF A;  4OZE A;  2JT2 A;  3P3C A;  4U3D A;  2O3Z A;  3P3E A;  4MDT A;  2J65 A;  3P76 A;  4ISA A;  4U3B A;  5DRR A;  4FW7 A;  4MQY A;  3PS1 A;  2IER A;  5DRQ A;  2GO3 A;  4IS9 A;  4LCG A;  1XXE A;  3PS2 A;  4FW5 A;  1YHC A;  3U1Y A;  3PS3 A;  3UHM A;  2GO4 A;  5DRO A;  3P3G A; 
#chains in the Genus database with same CATH topology
 4DV6 I;  4KHP I;  1Z5C A;  1RRE A;  4JI5 E;  1XMO I;  1N34 I;  4LCF A;  4JI1 I;  2O1U A;  3Q6M A;  1ELO A;  4LF8 I;  1RR9 A;  3L7Z B;  1Z0G A;  5LMN I;  2AJ4 A;  1IBK I;  2R42 A;  3T1Y E;  4JI8 I;  2NN6 C;  2CZ9 A;  4YHH E;  4B3T I;  2VQE I;  2IOQ A;  2C38 B;  2NN6 F;  5K36 E;  4MU0 A;  4PRV A;  5L3J A;  5K36 C;  2C39 A;  4WUC A;  3CDI A;  2UUB I;  5LMU I;  1OYS A;  4OX9 E;  2CGE A;  1USV A;  4DV0 E;  2UUC E;  4JG4 A;  2HHH E;  2IER A;  2E5L E;  3U1K A;  2BA0 D;  5ELW A;  2PNZ B;  3PS3 A;  3L7Z A;  4JV5 E;  4DR2 E;  1UDQ A;  4KQV A;  4MU1 A;  2JEA B;  2F4V E;  5C0X B;  1OYP A;  4JI7 I;  4DR5 E;  2O1V A;  4PU9 A;  3LPS A;  3J80 Q;  1EI1 A;  4DR1 I;  3H4L A;  1N0V C;  2BA0 G;  5DNX A;  4BA1 B;  2O1W A;  1XNR I;  3GME A;  4MU4 A;  4NXM I;  4DV7 I;  4K0K I;  2GO4 A;  2PNZ A;  3K85 A;  3J7A G;  1HNZ E;  2UU9 E;  2JE6 B;  1EA6 A;  2UXC I;  1XMQ E;  1H73 A;  2WP8 A;  2XEX A;  3KRN A;  3WU4 A;  1PIE A;  1HNW E;  5JEA B;  1Z5A A;  2F1D A;  1HK7 A;  3P3E A;  4FW7 A;  1PKP A;  4B3S E;  4JI3 I;  2PO2 B;  3WU6 A;  4DR4 E;  4X64 I;  1E3P A;  4BA1 A;  4LCG A;  1UDO A;  4GKK E;  3J81 C;  1BKN A;  1OJ4 A;  3UHM A;  1Z0V A;  3LNU A;  4LPF A;  5DRO A;  4B3R E;  4DXL A;  1USU A;  2GS8 A;  2Z5B B;  3F0N A;  5C0X D;  3T1H E;  1HR0 I;  1KTV A;  1Y5Y A;  3DD6 A;  2HK2 A;  4DV3 I;  4LFB I;  4IZJ A;  4DPW A;  4LF4 E;  1YH8 A;  2UXB I;  5IWA E;  2NN6 A;  3B82 A;  1S4E A;  1KIJ A;  4U3B A;  4JI0 E;  3P76 A;  1R6L A;  3OTO I;  1MU5 A;  4LF9 E;  4MU3 A;  4IFD B;  1U2R A;  4M1K A;  3PRY A;  2WNR B;  4DR7 I;  5C0X C;  4I3H A;  3B78 A;  3P3G A;  2ZM6 I;  1H7S A;  2VES A;  1Z59 A;  5C0X F;  4DV1 I;  4YY3 I;  3ZM7 A;  1XHK A;  2BM1 A;  5DNL A;  5JEA D;  2PO0 A;  4DUY E;  3GLL A;  2UXD E;  3T1Y I;  2R3V A;  2PNM A;  4IZK B;  3HUL A;  2UUA E;  4ED4 A;  1H72 C;  2O3Z A;  1I94 E;  1RHY A;  1FJG E;  3GCM A;  2NN6 E;  1N33 E;  2V2V A;  4DV2 E;  1A6F A;  2WW4 A;  4BA2 A;  2CVE A;  4OX9 I;  2IES A;  5JEA C;  4DV0 I;  4DPT A;  2Q2E B;  1FWL A;  4JI2 E;  4LFA E;  4FWD A;  2BR2 B;  1MG7 A;  5JEA F;  1N32 I;  2BA1 D;  2A2D A;  3QT8 A;  4KHP E;  4OZE A;  1KVK A;  3P3C A;  3M85 D;  4JV5 I;  4U3D A;  2J65 A;  3JAM C;  4DR3 I;  4DR2 I;  1HNX E;  4IFD D;  4IZK A;  2C37 B;  4X62 E;  1UEK A;  1NHH A;  2HKE A;  4AIM A;  1D6T A;  4DR5 I;  2VQF E;  2A2C A;  2BV3 A;  4OO1 D;  3J7A M;  1Z0E A;  2V2Z A;  2BA1 G;  4AID A;  4FN5 A;  1IBK E;  4MYU A;  2C38 A;  3M6A A;  4JI8 E;  3M85 G;  4LCH A;  4OKG A;  5A2Q C;  4HAC B;  3V2U C;  4IFD C;  1K47 A;  2HFS A;  2V8P A;  4JYA I;  4NXN I;  4LF7 I;  4IFD F;  4X65 E;  4AQY E;  3PS1 A;  1ZM4 A;  1J5E I;  5EKW A;  1HNZ I;  4DR6 E;  2UU9 I;  3GON A;  5LMU E;  1XMQ I;  3PYE A;  2C37 A;  1B63 A;  3LTO A;  1N0U A;  3ZZT A;  4OO1 F;  4UTG A;  1HNW I;  1N36 I;  1P42 A;  3P06 A;  1XNQ E;  4B3S I;  4DR4 I;  2X7I A;  4DV4 I;  4GKK I;  2CG9 A;  4FW4 A;  1Y4S A;  2JT2 A;  1FWK A;  4B3R I;  2JEB B;  2JEA A;  2V34 A;  4HAC A;  4FW9 A;  3HKM A;  4R1F A;  5C0X A;  1ZXM A;  4JI6 E;  2GO3 A;  4JI7 E;  2O1T A;  3ZZU A;  4URL A;  3D4J A;  4DR1 E;  4HYM A;  4QNK A;  1XNR E;  4USK A;  4LF6 E;  3PYG A;  4PRX A;  5FLX C;  2EFG A;  4JI4 E;  4DV7 E;  4J3D A;  5A2Q Q;  1Z0T A;  4DUZ E;  1FNM A;  4GKJ I;  4K0K E;  1H7U A;  3NZK A;  2JE6 A;  4Z7Y A;  1VI7 A;  4LFC E;  5IT9 C;  4ISA A;  5DRR A;  4X66 I;  1WUU A;  2J7K A;  2NPF A;  4P7A A;  5JEA A;  4JI5 I;  1UDS A;  4IS9 A;  4FW5 A;  4FWG A;  5C0X E;  1FI4 A;  1UDN A;  2UXD I;  1Y6Z A;  2PO2 A;  2DEI A;  2ZBK B;  2UUA I;  3CDJ A;  4DPY A;  2DEJ A;  5LL6 R;  1KKH A;  1I94 I;  1FJG I;  1Z0W A;  1ZM2 A;  5FLX Q;  4OO1 B;  1N33 I;  2Z5B A;  5GME A;  4DV2 I;  4FW6 A;  4DV5 E;  4YHH I;  1IBM E;  1HR0 E;  4HY1 A;  4LFA I;  3J81 Q;  1IBL E;  1ZM3 A;  2HKJ A;  3QT7 A;  5JEA E;  3OTO E;  4IFD A;  2WNR A;  5DRP A;  1VIS A;  1HNX I;  4LOM A;  4XTJ A;  2UUC I;  4X62 I;  4LF5 E;  3Q6N A;  2HHH I;  1Z5B A;  4B3M E;  5K36 D;  4QNJ A;  4DR7 E;  5EL9 A;  5BR8 E;  2E5L I;  5IT9 Q;  2ZM6 E;  4OO1 A;  3Q1Q A;  2VQF I;  4DV6 E;  1OYR A;  4DV1 E;  4YY3 E;  1XMO E;  1N34 E;  4MQY A;  4HXZ A;  3J80 C;  2E1R A;  3PYD A;  3ZKD A;  1FKA E;  2F4V I;  4Z7C A;  4JI1 E;  4ZVI A;  4LF8 E;  3WU5 A;  3B8H A;  4N3O A;  1E3H A;  4FWH A;  2GQ0 A;  4X65 I;  4AQY I;  1H74 A;  5LMN E;  4DR6 I;  5K36 F;  3ZZ0 A;  4IFD E;  4B3T E;  2VQE E;  2BR2 A;  1XNQ I;  4OO1 E;  5DRQ A;  1N32 E;  2UUB E;  2LJP A;  4OO1 C;  4GQU A;  2PO1 B;  3M7N D;  2BM0 A;  4DR3 E;  5GMD A;  2HFU A;  2WP8 B;  3ZKB A;  4MYT A;  1PVG A;  1R6M A;  2OI2 A;  1Y60 A;  4JI6 I;  5FWK A;  2VF3 A;  4DPX A;  3JAM Q;  2V2Q A;  4DU7 A;  2IOP A;  4MDT A;  3HJC A;  3K17 A;  4LF6 I;  4JI4 I;  3K1J A;  3M7N G;  4DUZ I;  1QZR A;  3T1H I;  4AM3 A;  1S16 A;  1Z0B A;  4JYA E;  3H1C A;  4NXN E;  3V5R A;  2HK3 A;  4LF4 I;  4LF7 E;  5IWA I;  1J5E E;  4IZJ B;  4LFC I;  4NXM E;  2PO1 A;  2AE8 A;  4WUD A;  4JI0 I;  2NN6 B;  1NHI A;  4LF9 I;  1ZXN A;  3PYF A;  4X66 E;  1N36 E;  4UT4 A;  4DU8 A;  5K36 B;  4WUB A;  2UXC E;  2Z5C B;  1DAR A;  4DV4 E;  1XXE A;  2JEB A;  3PS2 A;  1YHC A;  1Z0C A;  1B62 A;  2Z5E A;  4EMD A;  4DUY I;  4DV5 I;  2PO0 B;  1Y4U A;  1MX0 A;  4RPF A;  1IBM I;  4JI3 E;  2PNL A;  4FW3 A;  4X64 E;  4USM A;  2X36 A;  3QT5 A;  1IBL I;  3CWV A;  2ZIT A;  3QT6 A;  3WU3 A;  4BA2 B;  4GKJ E;  4P52 A;  4DV3 E;  5K36 A;  4NBQ A;  4LFB E;  4JI2 I;  3U1Y A;  4LF5 I;  1NHJ A;  4B3M I;  2UXB E;  4DPU A;  5BR8 I;  1ZM9 A;  3B4T A;  2Z5C A;  4IZJ D;  1NZ0 A;  2C39 B;  2NN6 D; 
#chains in the Genus database with same CATH homology
 2VES A;  2IES A;  1P42 A;  4J3D A;  4FW3 A;  5DRP A;  4LCH A;  4OKG A;  1YH8 A;  4FW6 A;  3NZK A;  4FW4 A;  4LCF A;  4OZE A;  2JT2 A;  3P3C A;  4U3D A;  2O3Z A;  3P3E A;  4MDT A;  2J65 A;  3P76 A;  4ISA A;  4U3B A;  5DRR A;  4FW7 A;  4MQY A;  3PS1 A;  2IER A;  5DRQ A;  2GO3 A;  4IS9 A;  4LCG A;  1XXE A;  3PS2 A;  4FW5 A;  1YHC A;  3U1Y A;  3PS3 A;  3UHM A;  2GO4 A;  5DRO A;  3P3G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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