2O3ZA

X-ray crystal structure of lpxc complexed with 3-heptyloxybenzoate
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
267
structure length
267
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.
pubmed doi rcsb
source organism Aquifex aeolicus
molecule tags Hydrolase
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 91
structure length 267
sequence length 267
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2006-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2o3zA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2o3zA02
2IESA 1P42A 4MQYA 4OKGA 2JT2A 2VESA 2J65A 1XXEA 5DRQA 1YH8A 2GO4A 3P3EA 5DRPA 4MDTA 4FW6A 4IS9A 4FW5A 4OZEA 3P3GA 3U1YA 2GO3A 4J3DA 4FW3A 3UHMA 3P3CA 4U3BA 4LCHA 2O3ZA 4FW7A 5DRRA 3PS3A 3P76A 3NZKA 4U3DA 5DROA 1YHCA 2IERA 4LCGA 3PS1A 4FW4A 4ISAA 4LCFA 3PS2A
chains in the Genus database with same CATH superfamily
5IWAE 5GMDA 4JI8I 4JI3E 4K0KE 5IT9Q 4JI2E 1K47A 4HACA 5DRQA 5EKWA 4MDTA 2PNZA 4JI3I 4K0KI 4DR2E 1IBLI 2PNLA 2O1VA 3UHMA 2BM1A 2J7KA 3V2UC 5JEAE 1USVA 2ZITA 5DRRA 3CDIA 4IFDF 1UDNA 3QT8A 4WUBA 2Z5CA 3KRNA 5JEAC 1XNQE 1HR0I 1Y6ZA 1N33I 5L3JA 3ZZTA 2XEXA 1Z5BA 2JEAB 2C37A 3L7ZA 4MU4A 4JI6I 3M7NG 3LPSA 4DR1I 5C0XD 2UXBI 3L7ZB 3J80C 4DR7E 3Q6MA 2CVEA 3LNUA 1ZM3A 4X62I 4DV7I 2PO2A 4P52A 4URLA 1I94I 4LCGA 4OO1C 1FNMA 4OX9I 3PS1A 2WP8B 3PRYA 2BA0G 4AQYI 2JEAA 4OKGA 4LF9I 5BR8E 3H4LA 2AE8A 5BR8I 2ZM6I 4FW6A 1HK7A 4YY3E 2JE6A 3M85G 1E3HA 1PVGA 1Z0WA 3GCMA 5EL9A 4FWHA 4JYAE 2O1TA 4JI4E 2WW4A 1N0VC 1NHJA 1ZM2A 2HKEA 1VI7A 2UXCI 1A6FA 4QNJA 2VF3A 4B3MI 1D6TA 1Z0CA 3T1YI 2NN6E 4JI7E 3P3EA 2PO1A 3J7AG 2GQ0A 4LFBE 2HK2A 4J3DA 1FKAE 3P3CA 1MG7A 3GMEA 4JI7I 4OO1D 3K1JA 3J81Q 4GKKE 1RHYA 2AJ4A 4DV3E 1H72C 3GLLA 4R1FA 2Q2EB 1VISA 1IBME 1N34I 1MX0A 4X65E 1FJGE 4DU7A 4DPYA 3PS2A 4IFDE 4DR2I 2JT2A 4BA2B 1ZM9A 3K17A 4PRXA 4LFCI 2O1UA 1ZM4A 5LMUI 2UXDE 4IFDB 4DUYI 2F1DA 2E5LE 2BM0A 2PO1B 4YHHE 2UXDI 2Z5CB 3Q1QA 2C38A 4U3DA 2X36A 4NXMI 4B3SE 4X64I 4JI0I 4JYAI 1J5EE 4X64E 3Q6NA 4DR5I 3M6AA 2BA1G 2J65A 2PNZB 3ZKDA 1FWKA 1YH8A 5FWKA 4LF6E 3B82A 1FI4A 2UXBE 4X66E 1MU5A 2LJPA 4UTGA 3P06A 4ZVIA 1S16A 5K36D 2F4VE 4LF7E 3M7ND 2O3ZA 2JE6B 1XMOI 2HK3A 4Z7YA 5GMEA 2NN6A 4LFBI 4LF5I 5DROA 4XTJA 3CDJA 4USKA 2Z5BB 4MU3A 2A2DA 2BR2A 2HFUA 2WP8A 5A2QQ 3JAMQ 4MQYA 2E1RA 1IBMI 4GQUA 4DV5I 2PO0A 5C0XA 1WUUA 1H73A 2VQEI 4IS9A 5LL6R 4IZJB 4JG4A 3WU6A 2C39A 2DEIA 4HXZA 1XNQI 3M85D 1OYSA 1EA6A 2DEJA 3PYDA 4BA1B 4DUYE 3ZKBA 1USUA 4DU8A 4MU0A 2WNRB 1IBKE 2HFSA 4M1KA 1R6LA 2CZ9A 4JI5I 2JEBA 5C0XC 1XXEA 1Z59A 1S4EA 1OYRA 2R3VA 1NHHA 4DV1I 4ED4A 4LPFA 2CGEA 1Z0EA 4FWGA 4DV4I 4X62E 4DV7E 4DV1E 5FLXQ 1N34E 4AIDA 1QZRA 3WU3A 3OTOI 2F4VI 4QNKA 4X65I 1FJGI 4DR3E 1NZ0A 1KTVA 4DR3I 5ELWA 4ISAA 1UEKA 4OO1A 4EMDA 3LTOA 1UDSA 5C0XF 4DV2E 4OO1B 3HULA 5LMUE 4LFCE 5K36B 4DR4I 2UU9E 4NXNI 4YY3I 2V2QA 3T1HE 4NBQA 3PYFA 2ZM6E 2UUCI 4OO1E 2GS8A 4LCHA 4B3SI 1XNRI 1XNRE 1HNXI 4B3TI 4JI4I 4DR6E 5C0XE 2UUCE 4JI1I 4DR5E 1HNWE 4LF8E 2OI2A 1HNWI 3QT5A 3F0NA 1XMQE 4LF8I 4KQVA 4B3ME 3QT6A 5JEAD 2VQFE 1N32E 1FWLA 3V5RA 2UXCE 1HNZE 1IBKI 1Z5AA 4IZKA 1U2RA 4HYMA 4LF7I 2JEBB 4IFDC 4IZKB 1Z0GA 2A2CA 2V2ZA 2IERA 2O1WA 3J80Q 1OJ4A 1Y5YA 2VQEE 4B3RE 2CG9A 4DPTA 4DV5E 4USMA 1BKNA 2VESA 4IZJA 1KVKA 2X7IA 1IBLE 4JV5I 2NN6F 3P3GA 5JEAF 5JEAB 4FW3A 4DR4E 4FW7A 1NHIA 1H7SA 1Y60A 1OYPA 2BA0D 4DXLA 5K36F 3PS3A 3P76A 1KKHA 1HR0E 1J5EI 2NN6B 4DPUA 4LCFA 4DPXA 1RR9A 5JEAA 5LMNI 3PYEA 4DR1E 2GO4A 3J7AM 4AM3A 5DRPA 4DV4E 1N36I 3D4JA 5LMNE 1I94E 5FLXC 3ZM7A 4IFDD 1UDQA 5DNLA 4WUCA 4DR7I 5IT9C 4LF5E 3DD6A 4DV6I 3NZKA 1Z0BA 4KHPI 4DV2I 2IOPA 2HKJA 4PU9A 4DV6E 4OX9E 1Z0TA 2C39B 1H7UA 1P42A 4DUZE 3HJCA 4AQYE 4FN5A 3HKMA 3U1KA 5IWAI 4NXNE 3B78A 2EFGA 4JI2I 3T1HI 5C0XB 4DUZI 3U1YA 2V2VA 2BA1D 4BA2A 4U3BA 1ELOA 1Y4UA 2Z5BA 4FWDA 4HY1A 1UDOA 1XMQI 2PO0B 5K36E 1RREA 2VQFI 1N32I 4MU1A 4LF4E 1N33E 4LF4I 2V8PA 2BR2B 2IESA 4LOMA 4JI5E 2NN6D 3B8HA 3WU5A 1N0UA 1PKPA 4IZJD 2R42A 3T1YE 4RPFA 4DV0E 4FW5A 5K36A 4DV3I 4HACB 3B4TA 4MYTA 4JI6E 2Z5EA 4DV0I 3OTOE 1N36E 3K85A 4B3RI 4GKKI 4JI8E 1DARA 3H1CA 3J81C 2WNRA 3QT7A 3JAMC 4JV5E 1Y4SA 2BV3A 4AIMA 4BA1A 3CWVA 4PRVA 4MYUA 4LF9E 4Z7CA 4OO1F 2C38B 4N3OA 3WU4A 2E5LI 5K36C 2PO2B 4OZEA 1ZXNA 2ZBKB 1EI1A 5DNXA 4GKJE 4P7AA 2UUBI 2UU9I 4IFDA 1ZXMA 2NPFA 4GKJI 4YHHI 4JI0E 1E3PA 1R6MA 1YHCA 2HHHE 2UUBE 4UT4A 4NXME 1Z5CA 3ZZUA 2UUAI 4JI1E 1HNXE 4B3TE 4LF6I 4DR6I 2UUAE 1PIEA 2V34A 2HHHI 1Z0VA 1HNZI 4X66I 1B63A 4FW9A 3ZZ0A 4WUDA 1H74A 2GO3A 2C37B 4DPWA 4I3HA 5A2QC 4LFAI 1XHKA 4KHPE 1B62A 1XMOE 2IOQA 4LFAE 3PYGA 1KIJA 4FW4A 3GONA 2NN6C 2PNMA
chains in the Genus database with same CATH topology
2IESA 1P42A 4MQYA 4OKGA 2JT2A 2VESA 2J65A 1XXEA 5DRQA 1YH8A 2GO4A 3P3EA 5DRPA 4MDTA 4FW6A 4IS9A 4FW5A 4OZEA 3P3GA 3U1YA 2GO3A 4J3DA 4FW3A 3UHMA 3P3CA 4U3BA 4LCHA 2O3ZA 4FW7A 5DRRA 3PS3A 3P76A 3NZKA 4U3DA 5DROA 1YHCA 2IERA 4LCGA 3PS1A 4FW4A 4ISAA 4LCFA 3PS2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IES A;  1P42 A;  4MQY A;  4OKG A;  2JT2 A;  2VES A;  2J65 A;  1XXE A;  5DRQ A;  1YH8 A;  2GO4 A;  3P3E A;  5DRP A;  4MDT A;  4FW6 A;  4IS9 A;  4FW5 A;  4OZE A;  3P3G A;  3U1Y A;  2GO3 A;  4J3D A;  4FW3 A;  3UHM A;  3P3C A;  4U3B A;  4LCH A;  2O3Z A;  4FW7 A;  5DRR A;  3PS3 A;  3P76 A;  3NZK A;  4U3D A;  5DRO A;  1YHC A;  2IER A;  4LCG A;  3PS1 A;  4FW4 A;  4ISA A;  4LCF A;  3PS2 A; 
#chains in the Genus database with same CATH topology
 5IWA E;  5GMD A;  4JI8 I;  4JI3 E;  4K0K E;  5IT9 Q;  4JI2 E;  1K47 A;  4HAC A;  5DRQ A;  5EKW A;  4MDT A;  2PNZ A;  4JI3 I;  4K0K I;  4DR2 E;  1IBL I;  2PNL A;  2O1V A;  3UHM A;  2BM1 A;  2J7K A;  3V2U C;  5JEA E;  1USV A;  2ZIT A;  5DRR A;  3CDI A;  4IFD F;  1UDN A;  3QT8 A;  4WUB A;  2Z5C A;  3KRN A;  5JEA C;  1XNQ E;  1HR0 I;  1Y6Z A;  1N33 I;  5L3J A;  3ZZT A;  2XEX A;  1Z5B A;  2JEA B;  2C37 A;  3L7Z A;  4MU4 A;  4JI6 I;  3M7N G;  3LPS A;  4DR1 I;  5C0X D;  2UXB I;  3L7Z B;  3J80 C;  4DR7 E;  3Q6M A;  2CVE A;  3LNU A;  1ZM3 A;  4X62 I;  4DV7 I;  2PO2 A;  4P52 A;  4URL A;  1I94 I;  4LCG A;  4OO1 C;  1FNM A;  4OX9 I;  3PS1 A;  2WP8 B;  3PRY A;  2BA0 G;  4AQY I;  2JEA A;  4OKG A;  4LF9 I;  5BR8 E;  3H4L A;  2AE8 A;  5BR8 I;  2ZM6 I;  4FW6 A;  1HK7 A;  4YY3 E;  2JE6 A;  3M85 G;  1E3H A;  1PVG A;  1Z0W A;  3GCM A;  5EL9 A;  4FWH A;  4JYA E;  2O1T A;  4JI4 E;  2WW4 A;  1N0V C;  1NHJ A;  1ZM2 A;  2HKE A;  1VI7 A;  2UXC I;  1A6F A;  4QNJ A;  2VF3 A;  4B3M I;  1D6T A;  1Z0C A;  3T1Y I;  2NN6 E;  4JI7 E;  3P3E A;  2PO1 A;  3J7A G;  2GQ0 A;  4LFB E;  2HK2 A;  4J3D A;  1FKA E;  3P3C A;  1MG7 A;  3GME A;  4JI7 I;  4OO1 D;  3K1J A;  3J81 Q;  4GKK E;  1RHY A;  2AJ4 A;  4DV3 E;  1H72 C;  3GLL A;  4R1F A;  2Q2E B;  1VIS A;  1IBM E;  1N34 I;  1MX0 A;  4X65 E;  1FJG E;  4DU7 A;  4DPY A;  3PS2 A;  4IFD E;  4DR2 I;  2JT2 A;  4BA2 B;  1ZM9 A;  3K17 A;  4PRX A;  4LFC I;  2O1U A;  1ZM4 A;  5LMU I;  2UXD E;  4IFD B;  4DUY I;  2F1D A;  2E5L E;  2BM0 A;  2PO1 B;  4YHH E;  2UXD I;  2Z5C B;  3Q1Q A;  2C38 A;  4U3D A;  2X36 A;  4NXM I;  4B3S E;  4X64 I;  4JI0 I;  4JYA I;  1J5E E;  4X64 E;  3Q6N A;  4DR5 I;  3M6A A;  2BA1 G;  2J65 A;  2PNZ B;  3ZKD A;  1FWK A;  1YH8 A;  5FWK A;  4LF6 E;  3B82 A;  1FI4 A;  2UXB E;  4X66 E;  1MU5 A;  2LJP A;  4UTG A;  3P06 A;  4ZVI A;  1S16 A;  5K36 D;  2F4V E;  4LF7 E;  3M7N D;  2O3Z A;  2JE6 B;  1XMO I;  2HK3 A;  4Z7Y A;  5GME A;  2NN6 A;  4LFB I;  4LF5 I;  5DRO A;  4XTJ A;  3CDJ A;  4USK A;  2Z5B B;  4MU3 A;  2A2D A;  2BR2 A;  2HFU A;  2WP8 A;  5A2Q Q;  3JAM Q;  4MQY A;  2E1R A;  1IBM I;  4GQU A;  4DV5 I;  2PO0 A;  5C0X A;  1WUU A;  1H73 A;  2VQE I;  4IS9 A;  5LL6 R;  4IZJ B;  4JG4 A;  3WU6 A;  2C39 A;  2DEI A;  4HXZ A;  1XNQ I;  3M85 D;  1OYS A;  1EA6 A;  2DEJ A;  3PYD A;  4BA1 B;  4DUY E;  3ZKB A;  1USU A;  4DU8 A;  4MU0 A;  2WNR B;  1IBK E;  2HFS A;  4M1K A;  1R6L A;  2CZ9 A;  4JI5 I;  2JEB A;  5C0X C;  1XXE A;  1Z59 A;  1S4E A;  1OYR A;  2R3V A;  1NHH A;  4DV1 I;  4ED4 A;  4LPF A;  2CGE A;  1Z0E A;  4FWG A;  4DV4 I;  4X62 E;  4DV7 E;  4DV1 E;  5FLX Q;  1N34 E;  4AID A;  1QZR A;  3WU3 A;  3OTO I;  2F4V I;  4QNK A;  4X65 I;  1FJG I;  4DR3 E;  1NZ0 A;  1KTV A;  4DR3 I;  5ELW A;  4ISA A;  1UEK A;  4OO1 A;  4EMD A;  3LTO A;  1UDS A;  5C0X F;  4DV2 E;  4OO1 B;  3HUL A;  5LMU E;  4LFC E;  5K36 B;  4DR4 I;  2UU9 E;  4NXN I;  4YY3 I;  2V2Q A;  3T1H E;  4NBQ A;  3PYF A;  2ZM6 E;  2UUC I;  4OO1 E;  2GS8 A;  4LCH A;  4B3S I;  1XNR I;  1XNR E;  1HNX I;  4B3T I;  4JI4 I;  4DR6 E;  5C0X E;  2UUC E;  4JI1 I;  4DR5 E;  1HNW E;  4LF8 E;  2OI2 A;  1HNW I;  3QT5 A;  3F0N A;  1XMQ E;  4LF8 I;  4KQV A;  4B3M E;  3QT6 A;  5JEA D;  2VQF E;  1N32 E;  1FWL A;  3V5R A;  2UXC E;  1HNZ E;  1IBK I;  1Z5A A;  4IZK A;  1U2R A;  4HYM A;  4LF7 I;  2JEB B;  4IFD C;  4IZK B;  1Z0G A;  2A2C A;  2V2Z A;  2IER A;  2O1W A;  3J80 Q;  1OJ4 A;  1Y5Y A;  2VQE E;  4B3R E;  2CG9 A;  4DPT A;  4DV5 E;  4USM A;  1BKN A;  2VES A;  4IZJ A;  1KVK A;  2X7I A;  1IBL E;  4JV5 I;  2NN6 F;  3P3G A;  5JEA F;  5JEA B;  4FW3 A;  4DR4 E;  4FW7 A;  1NHI A;  1H7S A;  1Y60 A;  1OYP A;  2BA0 D;  4DXL A;  5K36 F;  3PS3 A;  3P76 A;  1KKH A;  1HR0 E;  1J5E I;  2NN6 B;  4DPU A;  4LCF A;  4DPX A;  1RR9 A;  5JEA A;  5LMN I;  3PYE A;  4DR1 E;  2GO4 A;  3J7A M;  4AM3 A;  5DRP A;  4DV4 E;  1N36 I;  3D4J A;  5LMN E;  1I94 E;  5FLX C;  3ZM7 A;  4IFD D;  1UDQ A;  5DNL A;  4WUC A;  4DR7 I;  5IT9 C;  4LF5 E;  3DD6 A;  4DV6 I;  3NZK A;  1Z0B A;  4KHP I;  4DV2 I;  2IOP A;  2HKJ A;  4PU9 A;  4DV6 E;  4OX9 E;  1Z0T A;  2C39 B;  1H7U A;  1P42 A;  4DUZ E;  3HJC A;  4AQY E;  4FN5 A;  3HKM A;  3U1K A;  5IWA I;  4NXN E;  3B78 A;  2EFG A;  4JI2 I;  3T1H I;  5C0X B;  4DUZ I;  3U1Y A;  2V2V A;  2BA1 D;  4BA2 A;  4U3B A;  1ELO A;  1Y4U A;  2Z5B A;  4FWD A;  4HY1 A;  1UDO A;  1XMQ I;  2PO0 B;  5K36 E;  1RRE A;  2VQF I;  1N32 I;  4MU1 A;  4LF4 E;  1N33 E;  4LF4 I;  2V8P A;  2BR2 B;  2IES A;  4LOM A;  4JI5 E;  2NN6 D;  3B8H A;  3WU5 A;  1N0U A;  1PKP A;  4IZJ D;  2R42 A;  3T1Y E;  4RPF A;  4DV0 E;  4FW5 A;  5K36 A;  4DV3 I;  4HAC B;  3B4T A;  4MYT A;  4JI6 E;  2Z5E A;  4DV0 I;  3OTO E;  1N36 E;  3K85 A;  4B3R I;  4GKK I;  4JI8 E;  1DAR A;  3H1C A;  3J81 C;  2WNR A;  3QT7 A;  3JAM C;  4JV5 E;  1Y4S A;  2BV3 A;  4AIM A;  4BA1 A;  3CWV A;  4PRV A;  4MYU A;  4LF9 E;  4Z7C A;  4OO1 F;  2C38 B;  4N3O A;  3WU4 A;  2E5L I;  5K36 C;  2PO2 B;  4OZE A;  1ZXN A;  2ZBK B;  1EI1 A;  5DNX A;  4GKJ E;  4P7A A;  2UUB I;  2UU9 I;  4IFD A;  1ZXM A;  2NPF A;  4GKJ I;  4YHH I;  4JI0 E;  1E3P A;  1R6M A;  1YHC A;  2HHH E;  2UUB E;  4UT4 A;  4NXM E;  1Z5C A;  3ZZU A;  2UUA I;  4JI1 E;  1HNX E;  4B3T E;  4LF6 I;  4DR6 I;  2UUA E;  1PIE A;  2V34 A;  2HHH I;  1Z0V A;  1HNZ I;  4X66 I;  1B63 A;  4FW9 A;  3ZZ0 A;  4WUD A;  1H74 A;  2GO3 A;  2C37 B;  4DPW A;  4I3H A;  5A2Q C;  4LFA I;  1XHK A;  4KHP E;  1B62 A;  1XMO E;  2IOQ A;  4LFA E;  3PYG A;  1KIJ A;  4FW4 A;  3GON A;  2NN6 C;  2PNM A; 
#chains in the Genus database with same CATH homology
 2IES A;  1P42 A;  4MQY A;  4OKG A;  2JT2 A;  2VES A;  2J65 A;  1XXE A;  5DRQ A;  1YH8 A;  2GO4 A;  3P3E A;  5DRP A;  4MDT A;  4FW6 A;  4IS9 A;  4FW5 A;  4OZE A;  3P3G A;  3U1Y A;  2GO3 A;  4J3D A;  4FW3 A;  3UHM A;  3P3C A;  4U3B A;  4LCH A;  2O3Z A;  4FW7 A;  5DRR A;  3PS3 A;  3P76 A;  3NZK A;  4U3D A;  5DRO A;  1YHC A;  2IER A;  4LCG A;  3PS1 A;  4FW4 A;  4ISA A;  4LCF A;  3PS2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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