4LCGA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-050 complex
Total Genus 93
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
296
structure length
296
Chain Sequence
b'MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/antibiotic
total genus 93
structure length 296
sequence length 296
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4lcgA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4lcgA02
4FW5A 4OZEA 4FW3A 5DRRA 5DROA 2GO4A 2GO3A 4LCFA 2IERA 3U1YA 3PS3A 4U3DA 2VESA 4IS9A 1XXEA 4MQYA 4OKGA 4FW4A 5DRPA 3NZKA 4J3DA 3P3EA 2J65A 4MDTA 4LCHA 3UHMA 3P76A 4LCGA 1YH8A 2JT2A 5DRQA 4U3BA 3PS2A 4FW7A 3P3GA 4FW6A 2IESA 3P3CA 3PS1A 4ISAA 1YHCA 1P42A 2O3ZA
chains in the Genus database with same CATH superfamily
4WUCA 1ZM2A 4YHHE 3J81Q 4LF9I 1Y6ZA 1OYRA 5IT9C 3B82A 1NHIA 4AIMA 2C38B 4X65E 2PNZA 4PU9A 1ZM3A 5C0XC 2ZM6E 4GKKI 1FI4A 1Z5AA 1N32E 3B8HA 4BA2B 4GQUA 1E3HA 4USKA 4JI8E 3T1YI 2UXBI 4OO1A 4WUBA 4B3SE 1RHYA 3PS2A 3Q6NA 4LF6E 4LF5E 4JI0I 4OO1F 4YY3I 2IOQA 1EI1A 4DV4I 1PKPA 2BA1G 2GO3A 1IBLE 1VI7A 2Z5BB 2JEBA 3HKMA 4IZJB 4IS9A 3WU5A 4URLA 2IOPA 2WP8A 5EL9A 1S16A 1VISA 4JI7E 5BR8I 4B3TE 1B62A 3P76A 2XEXA 4FWHA 4AQYI 5DRQA 4AM3A 4LF4I 4UTGA 2UU9E 1Z5BA 2UUBE 2O1TA 1P42A 2HKJA 4DU8A 4UT4A 2E1RA 3M85D 1HNZE 4DUYE 5FLXQ 3ZZTA 1NHHA 3WU6A 4LF7E 2BA0G 1H74A 2UXDE 3LTOA 2HFUA 5LMNI 1H73A 1KTVA 4DR7E 2X7IA 4LF4E 1OJ4A 4MU1A 4M1KA 2AE8A 2F4VI 4MYTA 1FNMA 1HNWI 1QZRA 2GQ0A 4ISAA 2C37A 2WNRA 1N33E 1H7SA 2BR2A 4BA1A 4MU4A 2NN6A 4DR1I 3V5RA 3J81C 1UDQA 3PYGA 1XNRE 3L7ZA 2UXCE 2NN6F 4JV5E 4KHPI 4P52A 4IFDC 4QNKA 4DV6E 2UUAE 4JI3E 2AJ4A 4DR4E 2PO2A 1I94I 1KVKA 3DD6A 3LPSA 1Z0GA 3J7AG 3J80Q 4B3ME 4FW5A 4LFBI 1A6FA 3KRNA 3M6AA 2GO4A 4JI5I 4LFCE 2O1WA 4DR6E 3U1KA 4JI1E 4GKJE 1RR9A 1OYSA 4IZJD 1HNXE 1N0VC 4USMA 2UUCE 4X65I 4NXNE 1HR0E 1S4EA 4PRVA 2ZM6I 1YH8A 4DPUA 2VQEE 1N32I 1FWLA 4JI2E 3P3GA 2PO0B 4JI8I 1YHCA 4R1FA 5K36C 2C38A 3QT6A 4MU3A 5C0XB 4B3SI 2NPFA 1Z5CA 4BA2A 1DARA 1IBKE 4LF6I 1RREA 4LF5I 5FLXC 2Z5EA 4LF8I 2V34A 2CZ9A 1FWKA 1IBLI 4LFAE 1FKAE 2J65A 2Z5CB 3UHMA 1KIJA 2BV3A 2BA0D 3ZZUA 4DUZI 1Y60A 5JEAC 1USVA 4DV2E 4FW6A 4FN5A 2J7KA 2Z5BA 4ED4A 4JI7I 4B3TI 5EKWA 1Z0CA 4DR3I 4LF8E 2EFGA 2UU9I 1N0UA 2UUBI 4FWGA 5LMUE 3OTOE 3ZKDA 1EA6A 1HNZI 4DUYI 4DUZE 2JE6B 2A2DA 4J3DA 4LF7I 2UXDI 2PNZB 3ZKBA 2ZITA 1HK7A 4DR7I 2V2VA 4FW7A 4DR3E 1H72C 4X62E 4P7AA 4JYAE 4FW3A 3J80C 3T1HE 1N33I 3PS3A 4OO1C 4FW9A 4EMDA 4DV3I 4RPFA 2JEAB 4DPXA 2HK3A 3P3EA 1UDSA 3PYFA 4DU7A 1XNRI 4DR5E 2UXCI 4JV5I 4LPFA 2WP8B 4DV7E 4DV6I 2UUAI 3H4LA 4JI3I 4K0KE 4X64E 3P06A 4DV5I 4DR4I 4IFDE 2HFSA 2E5LE 4IFDB 4DV3E 1FJGI 4OX9E 5C0XD 4B3RE 3CDIA 4B3MI 2BM0A 4JI4E 1WUUA 1UDNA 2V8PA 4DV0E 1XHKA 3K1JA 4I3HA 4HYMA 3NZKA 4LFCI 4Z7YA 1NHJA 4NBQA 4LCHA 4HACA 4JG4A 4PRXA 4DV5E 1N34E 4DR6I 4JI1I 1Y4SA 4U3BA 4GKJI 3JAMC 3H1CA 1HNXI 1FJGE 2IESA 3P3CA 2HHHE 2C39B 2UUCI 2PNMA 5A2QQ 4NXNI 1HR0I 2CG9A 1PIEA 2VQEI 1E3PA 4MU0A 4JI2I 3J7AM 1MX0A 1XNQE 4LOMA 5GMDA 5IWAI 4ZVIA 4U3DA 4BA1B 1ZXMA 2VESA 2PO1B 1Z0TA 2GS8A 2OI2A 1IBKI 4IZKB 2PO0A 2VF3A 3L7ZB 5K36B 1R6MA 2NN6C 2JT2A 3Q6MA 4LFAI 3M7NG 1J5EE 2O3ZA 5C0XE 2PO2B 5C0XF 5IWAE 2HKEA 2Q2EB 4DV2I 5DROA 4KQVA 2IERA 2X36A 4NXME 1XMQI 5JEAE 1XXEA 5DNXA 3ZZ0A 5JEAB 5DRPA 1B63A 2CGEA 5LMUI 3OTOI 3JAMQ 1H7UA 5DNLA 2HK2A 1U2RA 2O1VA 3ZM7A 3V2UC 4IZJA 1NZ0A 1XMQE 1N36E 3CDJA 5DRRA 4DR2E 2JE6A 1XMOE 1Z0VA 4X62I 4JYAI 5ELWA 4IFDD 4DV1E 4HY1A 3QT8A 3T1HI 4FWDA 4X66E 3K17A 1PVGA 2R3VA 3QT5A 4LF9E 3D4JA 1Z59A 2ZBKB 4OO1E 4DR5I 4OZEA 5LL6R 3HJCA 3K85A 2DEJA 4OO1B 4GKKE 4N3OA 2JEAA 4DV7I 1UEKA 2WW4A 5A2QC 4LCFA 4K0KI 4X64I 2BM1A 5FWKA 3T1YE 3CWVA 2UXBE 4JI6I 1ZM4A 4FW4A 2E5LI 4XTJA 3WU4A 4OX9I 2NN6D 4B3RI 2JEBB 4JI4I 4JI0E 4YY3E 4DV0I 2DEIA 4DV4E 4IFDA 3GCMA 5K36D 1ZM9A 3GMEA 5IT9Q 1OYPA 3B78A 1N34I 4DPWA 2R42A 4JI6E 1R6LA 4IFDF 1K47A 2F1DA 2HHHI 2LJPA 5BR8E 4DXLA 3M7ND 1Y4UA 4OKGA 4AQYE 1ELOA 1MG7A 3GONA 3HULA 2VQFI 2C39A 3QT7A 1XNQI 1D6TA 5JEAD 4AIDA 1KKHA 1IBMI 1Y5YA 1UDOA 3PS1A 4MDTA 2V2ZA 2PNLA 4DPTA 5LMNE 2PO1A 3Q1QA 1Z0EA 3PRYA 4IZKA 3WU3A 1J5EI 3GLLA 2C37B 2NN6E 2WNRB 4QNJA 2VQFE 2BR2B 5K36A 4DPYA 3PYEA 4MQYA 2A2CA 4WUDA 2F4VE 2NN6B 1USUA 1IBME 1HNWE 3M85G 5K36E 4NXMI 5K36F 1ZXNA 1Z0WA 5C0XA 3F0NA 4DR1E 4HACB 2CVEA 5L3JA 4HXZA 4KHPE 5JEAA 2O1UA 4OO1D 3U1YA 4YHHI 2Z5CA 1N36I 1I94E 5JEAF 4DR2I 3PYDA 1XMOI 3LNUA 4MYUA 2BA1D 1MU5A 1Z0BA 3B4TA 4LCGA 4LFBE 4Z7CA 1BKNA 4DV1I 4JI5E 2V2QA 4X66I 5GMEA
chains in the Genus database with same CATH topology
4FW5A 4OZEA 4FW3A 5DRRA 5DROA 2GO4A 2GO3A 4LCFA 2IERA 3U1YA 3PS3A 4U3DA 2VESA 4IS9A 1XXEA 4MQYA 4OKGA 4FW4A 5DRPA 3NZKA 4J3DA 3P3EA 2J65A 4MDTA 4LCHA 3UHMA 3P76A 4LCGA 1YH8A 2JT2A 5DRQA 4U3BA 3PS2A 4FW7A 3P3GA 4FW6A 2IESA 3P3CA 3PS1A 4ISAA 1YHCA 1P42A 2O3ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FW5 A;  4OZE A;  4FW3 A;  5DRR A;  5DRO A;  2GO4 A;  2GO3 A;  4LCF A;  2IER A;  3U1Y A;  3PS3 A;  4U3D A;  2VES A;  4IS9 A;  1XXE A;  4MQY A;  4OKG A;  4FW4 A;  5DRP A;  3NZK A;  4J3D A;  3P3E A;  2J65 A;  4MDT A;  4LCH A;  3UHM A;  3P76 A;  4LCG A;  1YH8 A;  2JT2 A;  5DRQ A;  4U3B A;  3PS2 A;  4FW7 A;  3P3G A;  4FW6 A;  2IES A;  3P3C A;  3PS1 A;  4ISA A;  1YHC A;  1P42 A;  2O3Z A; 
#chains in the Genus database with same CATH topology
 4WUC A;  1ZM2 A;  4YHH E;  3J81 Q;  4LF9 I;  1Y6Z A;  1OYR A;  5IT9 C;  3B82 A;  1NHI A;  4AIM A;  2C38 B;  4X65 E;  2PNZ A;  4PU9 A;  1ZM3 A;  5C0X C;  2ZM6 E;  4GKK I;  1FI4 A;  1Z5A A;  1N32 E;  3B8H A;  4BA2 B;  4GQU A;  1E3H A;  4USK A;  4JI8 E;  3T1Y I;  2UXB I;  4OO1 A;  4WUB A;  4B3S E;  1RHY A;  3PS2 A;  3Q6N A;  4LF6 E;  4LF5 E;  4JI0 I;  4OO1 F;  4YY3 I;  2IOQ A;  1EI1 A;  4DV4 I;  1PKP A;  2BA1 G;  2GO3 A;  1IBL E;  1VI7 A;  2Z5B B;  2JEB A;  3HKM A;  4IZJ B;  4IS9 A;  3WU5 A;  4URL A;  2IOP A;  2WP8 A;  5EL9 A;  1S16 A;  1VIS A;  4JI7 E;  5BR8 I;  4B3T E;  1B62 A;  3P76 A;  2XEX A;  4FWH A;  4AQY I;  5DRQ A;  4AM3 A;  4LF4 I;  4UTG A;  2UU9 E;  1Z5B A;  2UUB E;  2O1T A;  1P42 A;  2HKJ A;  4DU8 A;  4UT4 A;  2E1R A;  3M85 D;  1HNZ E;  4DUY E;  5FLX Q;  3ZZT A;  1NHH A;  3WU6 A;  4LF7 E;  2BA0 G;  1H74 A;  2UXD E;  3LTO A;  2HFU A;  5LMN I;  1H73 A;  1KTV A;  4DR7 E;  2X7I A;  4LF4 E;  1OJ4 A;  4MU1 A;  4M1K A;  2AE8 A;  2F4V I;  4MYT A;  1FNM A;  1HNW I;  1QZR A;  2GQ0 A;  4ISA A;  2C37 A;  2WNR A;  1N33 E;  1H7S A;  2BR2 A;  4BA1 A;  4MU4 A;  2NN6 A;  4DR1 I;  3V5R A;  3J81 C;  1UDQ A;  3PYG A;  1XNR E;  3L7Z A;  2UXC E;  2NN6 F;  4JV5 E;  4KHP I;  4P52 A;  4IFD C;  4QNK A;  4DV6 E;  2UUA E;  4JI3 E;  2AJ4 A;  4DR4 E;  2PO2 A;  1I94 I;  1KVK A;  3DD6 A;  3LPS A;  1Z0G A;  3J7A G;  3J80 Q;  4B3M E;  4FW5 A;  4LFB I;  1A6F A;  3KRN A;  3M6A A;  2GO4 A;  4JI5 I;  4LFC E;  2O1W A;  4DR6 E;  3U1K A;  4JI1 E;  4GKJ E;  1RR9 A;  1OYS A;  4IZJ D;  1HNX E;  1N0V C;  4USM A;  2UUC E;  4X65 I;  4NXN E;  1HR0 E;  1S4E A;  4PRV A;  2ZM6 I;  1YH8 A;  4DPU A;  2VQE E;  1N32 I;  1FWL A;  4JI2 E;  3P3G A;  2PO0 B;  4JI8 I;  1YHC A;  4R1F A;  5K36 C;  2C38 A;  3QT6 A;  4MU3 A;  5C0X B;  4B3S I;  2NPF A;  1Z5C A;  4BA2 A;  1DAR A;  1IBK E;  4LF6 I;  1RRE A;  4LF5 I;  5FLX C;  2Z5E A;  4LF8 I;  2V34 A;  2CZ9 A;  1FWK A;  1IBL I;  4LFA E;  1FKA E;  2J65 A;  2Z5C B;  3UHM A;  1KIJ A;  2BV3 A;  2BA0 D;  3ZZU A;  4DUZ I;  1Y60 A;  5JEA C;  1USV A;  4DV2 E;  4FW6 A;  4FN5 A;  2J7K A;  2Z5B A;  4ED4 A;  4JI7 I;  4B3T I;  5EKW A;  1Z0C A;  4DR3 I;  4LF8 E;  2EFG A;  2UU9 I;  1N0U A;  2UUB I;  4FWG A;  5LMU E;  3OTO E;  3ZKD A;  1EA6 A;  1HNZ I;  4DUY I;  4DUZ E;  2JE6 B;  2A2D A;  4J3D A;  4LF7 I;  2UXD I;  2PNZ B;  3ZKB A;  2ZIT A;  1HK7 A;  4DR7 I;  2V2V A;  4FW7 A;  4DR3 E;  1H72 C;  4X62 E;  4P7A A;  4JYA E;  4FW3 A;  3J80 C;  3T1H E;  1N33 I;  3PS3 A;  4OO1 C;  4FW9 A;  4EMD A;  4DV3 I;  4RPF A;  2JEA B;  4DPX A;  2HK3 A;  3P3E A;  1UDS A;  3PYF A;  4DU7 A;  1XNR I;  4DR5 E;  2UXC I;  4JV5 I;  4LPF A;  2WP8 B;  4DV7 E;  4DV6 I;  2UUA I;  3H4L A;  4JI3 I;  4K0K E;  4X64 E;  3P06 A;  4DV5 I;  4DR4 I;  4IFD E;  2HFS A;  2E5L E;  4IFD B;  4DV3 E;  1FJG I;  4OX9 E;  5C0X D;  4B3R E;  3CDI A;  4B3M I;  2BM0 A;  4JI4 E;  1WUU A;  1UDN A;  2V8P A;  4DV0 E;  1XHK A;  3K1J A;  4I3H A;  4HYM A;  3NZK A;  4LFC I;  4Z7Y A;  1NHJ A;  4NBQ A;  4LCH A;  4HAC A;  4JG4 A;  4PRX A;  4DV5 E;  1N34 E;  4DR6 I;  4JI1 I;  1Y4S A;  4U3B A;  4GKJ I;  3JAM C;  3H1C A;  1HNX I;  1FJG E;  2IES A;  3P3C A;  2HHH E;  2C39 B;  2UUC I;  2PNM A;  5A2Q Q;  4NXN I;  1HR0 I;  2CG9 A;  1PIE A;  2VQE I;  1E3P A;  4MU0 A;  4JI2 I;  3J7A M;  1MX0 A;  1XNQ E;  4LOM A;  5GMD A;  5IWA I;  4ZVI A;  4U3D A;  4BA1 B;  1ZXM A;  2VES A;  2PO1 B;  1Z0T A;  2GS8 A;  2OI2 A;  1IBK I;  4IZK B;  2PO0 A;  2VF3 A;  3L7Z B;  5K36 B;  1R6M A;  2NN6 C;  2JT2 A;  3Q6M A;  4LFA I;  3M7N G;  1J5E E;  2O3Z A;  5C0X E;  2PO2 B;  5C0X F;  5IWA E;  2HKE A;  2Q2E B;  4DV2 I;  5DRO A;  4KQV A;  2IER A;  2X36 A;  4NXM E;  1XMQ I;  5JEA E;  1XXE A;  5DNX A;  3ZZ0 A;  5JEA B;  5DRP A;  1B63 A;  2CGE A;  5LMU I;  3OTO I;  3JAM Q;  1H7U A;  5DNL A;  2HK2 A;  1U2R A;  2O1V A;  3ZM7 A;  3V2U C;  4IZJ A;  1NZ0 A;  1XMQ E;  1N36 E;  3CDJ A;  5DRR A;  4DR2 E;  2JE6 A;  1XMO E;  1Z0V A;  4X62 I;  4JYA I;  5ELW A;  4IFD D;  4DV1 E;  4HY1 A;  3QT8 A;  3T1H I;  4FWD A;  4X66 E;  3K17 A;  1PVG A;  2R3V A;  3QT5 A;  4LF9 E;  3D4J A;  1Z59 A;  2ZBK B;  4OO1 E;  4DR5 I;  4OZE A;  5LL6 R;  3HJC A;  3K85 A;  2DEJ A;  4OO1 B;  4GKK E;  4N3O A;  2JEA A;  4DV7 I;  1UEK A;  2WW4 A;  5A2Q C;  4LCF A;  4K0K I;  4X64 I;  2BM1 A;  5FWK A;  3T1Y E;  3CWV A;  2UXB E;  4JI6 I;  1ZM4 A;  4FW4 A;  2E5L I;  4XTJ A;  3WU4 A;  4OX9 I;  2NN6 D;  4B3R I;  2JEB B;  4JI4 I;  4JI0 E;  4YY3 E;  4DV0 I;  2DEI A;  4DV4 E;  4IFD A;  3GCM A;  5K36 D;  1ZM9 A;  3GME A;  5IT9 Q;  1OYP A;  3B78 A;  1N34 I;  4DPW A;  2R42 A;  4JI6 E;  1R6L A;  4IFD F;  1K47 A;  2F1D A;  2HHH I;  2LJP A;  5BR8 E;  4DXL A;  3M7N D;  1Y4U A;  4OKG A;  4AQY E;  1ELO A;  1MG7 A;  3GON A;  3HUL A;  2VQF I;  2C39 A;  3QT7 A;  1XNQ I;  1D6T A;  5JEA D;  4AID A;  1KKH A;  1IBM I;  1Y5Y A;  1UDO A;  3PS1 A;  4MDT A;  2V2Z A;  2PNL A;  4DPT A;  5LMN E;  2PO1 A;  3Q1Q A;  1Z0E A;  3PRY A;  4IZK A;  3WU3 A;  1J5E I;  3GLL A;  2C37 B;  2NN6 E;  2WNR B;  4QNJ A;  2VQF E;  2BR2 B;  5K36 A;  4DPY A;  3PYE A;  4MQY A;  2A2C A;  4WUD A;  2F4V E;  2NN6 B;  1USU A;  1IBM E;  1HNW E;  3M85 G;  5K36 E;  4NXM I;  5K36 F;  1ZXN A;  1Z0W A;  5C0X A;  3F0N A;  4DR1 E;  4HAC B;  2CVE A;  5L3J A;  4HXZ A;  4KHP E;  5JEA A;  2O1U A;  4OO1 D;  3U1Y A;  4YHH I;  2Z5C A;  1N36 I;  1I94 E;  5JEA F;  4DR2 I;  3PYD A;  1XMO I;  3LNU A;  4MYU A;  2BA1 D;  1MU5 A;  1Z0B A;  3B4T A;  4LCG A;  4LFB E;  4Z7C A;  1BKN A;  4DV1 I;  4JI5 E;  2V2Q A;  4X66 I;  5GME A; 
#chains in the Genus database with same CATH homology
 4FW5 A;  4OZE A;  4FW3 A;  5DRR A;  5DRO A;  2GO4 A;  2GO3 A;  4LCF A;  2IER A;  3U1Y A;  3PS3 A;  4U3D A;  2VES A;  4IS9 A;  1XXE A;  4MQY A;  4OKG A;  4FW4 A;  5DRP A;  3NZK A;  4J3D A;  3P3E A;  2J65 A;  4MDT A;  4LCH A;  3UHM A;  3P76 A;  4LCG A;  1YH8 A;  2JT2 A;  5DRQ A;  4U3B A;  3PS2 A;  4FW7 A;  3P3G A;  4FW6 A;  2IES A;  3P3C A;  3PS1 A;  4ISA A;  1YHC A;  1P42 A;  2O3Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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