4FW3A

Crystal structure of the lpxc in complex with n-[(2s)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide inhibitor
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
302
structure length
302
Chain Sequence
b'SNAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Crystal Structure of the LpxC
rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/hydrolase inhibitor
total genus 88
structure length 302
sequence length 302
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw3A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw3A02
4LCHA 5DROA 3P76A 3PS1A 3PS2A 4OZEA 3NZKA 1P42A 4LCGA 4FW6A 4LCFA 4OKGA 2IESA 2IERA 5DRRA 2VESA 3U1YA 4J3DA 2GO4A 3P3CA 2JT2A 1YH8A 3UHMA 1YHCA 4FW7A 4MDTA 1XXEA 2GO3A 2O3ZA 4U3BA 5DRPA 3PS3A 4ISAA 5DRQA 4FW5A 4FW3A 3P3GA 3P3EA 4FW4A 2J65A 4U3DA 4IS9A 4MQYA
chains in the Genus database with same CATH superfamily
5C0XE 4IFDF 1OYSA 4HACA 5IT9C 2NN6C 2WW4A 4DR5E 4FWHA 4PRXA 4YY3E 1B63A 1HNWE 4LF5I 1PVGA 2VESA 2HKJA 2VQFI 4KQVA 1H74A 4FW7A 1KTVA 5IT9Q 3T1HI 3JAMC 4AQYE 4U3BA 1NHIA 1IBME 4X65E 1Z0BA 1U2RA 3P3EA 4MU3A 2CZ9A 5JEAE 1IBLE 4GKKE 4JYAE 4DV4I 3PS2A 4JI2E 3QT8A 3JAMQ 1KIJA 1Z5CA 2IERA 1Y60A 4LOMA 2UUCE 3H4LA 5LMUI 2NN6E 1ZM9A 2F1DA 1N0VC 4DV3I 2IOPA 4DR3I 2BA1D 3T1YE 4P52A 1Z5BA 4DV1E 4DV5I 2HFSA 4OO1B 3HULA 4YHHE 1UDQA 3K1JA 1VI7A 4DR4E 2JE6A 4DR5I 1H73A 1MX0A 1N0UA 3PYEA 2CGEA 4WUDA 1HNWI 1YHCA 1IBKE 3GCMA 5EKWA 1ZM4A 4DPTA 1OJ4A 2Z5CA 2BA0D 4AQYI 4Z7YA 1IBMI 4JI8E 2PNMA 4LF5E 5K36E 1Y4SA 4DU8A 4GKKI 4JYAI 1FI4A 3M7ND 4JI2I 4LF7E 3B82A 2C39B 3F0NA 1WUUA 3T1HE 1ZM3A 1H7UA 4IFDA 3WU5A 4IFDC 4MDTA 4HXZA 4JV5E 4FWGA 3PRYA 1UDOA 4OO1E 2UUCI 1Z0CA 4IZJB 2JEAB 3KRNA 2WNRA 1USVA 4LFBI 4IZJA 4USMA 4JI4E 3T1YI 4IFDD 4BA1A 2JEAA 3P76A 4I3HA 4OZEA 4K0KE 1Y6ZA 4DV1I 2BM0A 4URLA 3M6AA 1ZXMA 4DV3E 4DR3E 4ED4A 4DR4I 2V34A 2R42A 3WU6A 3K85A 1HNZE 4FW9A 1H7SA 3B78A 3B8HA 4DR2E 4DUYE 4B3RE 4X64E 1S16A 4IS9A 3LNUA 4DR1E 3ZZ0A 4DPWA 4MU4A 3OTOE 3J80Q 2HFUA 4LCFA 1RHYA 4JI8I 2O1UA 1OYRA 1Z0EA 4MYUA 4DV6I 3J7AM 2PNLA 4LFCE 3QT5A 4N3OA 3Q6NA 1RR9A 2GQ0A 2BR2B 1VISA 2GS8A 4LF7I 4GKJI 2BR2A 1XNQE 4DPUA 2JEBB 2O1VA 2Q2EB 3M85G 1E3PA 5C0XF 3DD6A 4JV5I 4P7AA 2DEIA 3J7AG 2JEBA 2F4VI 5LL6R 4LFAI 5BR8E 3QT7A 2X36A 2C37A 3NZKA 1Z0WA 4JI4I 2V2QA 5A2QC 4K0KI 4JI0I 1I94I 4MU1A 2LJPA 1USUA 1XXEA 3J81C 3Q1QA 4NXME 5DRPA 3CWVA 4LFBE 2O1WA 5JEAF 5FLXC 4LF9E 2J65A 3PYDA 4DR7E 1HNZI 4LF6E 4Z7CA 5A2QQ 4JI1E 4BA2B 5DROA 4DR2I 4X62I 4DUYI 4B3RI 2OI2A 3LTOA 4PU9A 4X64I 4BA2A 4DR1I 2JE6B 4DV0E 3J81Q 4DR6E 4OKGA 2BV3A 1FKAE 4QNJA 3OTOI 2PO0A 4DV7I 4J3DA 1KKHA 2JT2A 1MU5A 3LPSA 2Z5CB 4R1FA 4UTGA 4LFCI 1EA6A 4DXLA 3PYFA 5IWAI 4LPFA 4JI3I 1XNQI 2ZM6E 4DV6E 5FWKA 1P42A 5BR8I 4IFDB 4JI6I 2O1TA 4JI7I 4LF8E 1HNXE 2PNZB 4GKJE 5GMEA 3PYGA 2PO2B 2UXDE 2XEXA 4AIDA 1ELOA 1HR0E 2PNZA 4FWDA 4XTJA 2V2VA 2WNRB 2PO2A 2F4VE 2BA0G 4LFAE 4FW4A 4BA1B 4NXMI 2CVEA 2UU9I 1ZM2A 2CG9A 5K36F 3CDJA 1KVKA 3D4JA 4JG4A 4LF9I 4DR7I 4FW6A 5C0XB 4JI1I 4JI0E 4LF6I 3M7NG 1UDNA 2A2CA 2EFGA 4HYMA 1I94E 5DRRA 4WUBA 5C0XA 2VQEE 1N34E 5C0XC 3GONA 3HJCA 4USKA 4DV0I 4DR6I 4B3TI 1MG7A 3V5RA 4OO1F 5DNXA 4LF4E 4NXNE 4JI5I 5LMNI 1N33E 2HK2A 4RPFA 4DUZI 4FW5A 1NHHA 4X62E 1NHJA 2HK3A 5C0XD 4MQYA 1N32E 4IFDE 2X7IA 4AM3A 2E5LE 2V8PA 1Z0GA 2Z5BA 5JEAB 3GLLA 3ZZUA 4DV7E 2ZM6I 4PRVA 3GMEA 5JEAA 3WU3A 2PO1B 5JEAC 3U1YA 3V2UC 1Y4UA 1HK7A 2PO1A 5IWAE 1XMOI 3B4TA 3H1CA 4LF8I 1HNXI 1UDSA 2HKEA 4JI3E 3PS3A 4X66E 1Z0VA 1Y5YA 2C38B 2UXDI 3ZKBA 3ZM7A 1A6FA 5JEAD 1HR0I 4OX9E 2WP8A 4LCHA 2NN6A 2C37B 1R6LA 2C38A 5ELWA 2E1RA 4JI6E 1Z59A 4QNKA 4JI7E 3QT6A 2IESA 1UEKA 4NBQA 2UXBI 1H72C 1RREA 3P3CA 1FJGE 2NN6D 1YH8A 4FN5A 1J5EE 2VQEI 1D6TA 1OYPA 2AE8A 1N34I 4DPYA 1N36I 4B3MI 1XMQE 5GMDA 2UU9E 2HHHE 1Z0TA 2NPFA 4IZKB 4LF4I 3K17A 4NXNI 2DEJA 1N33I 4GQUA 2R3VA 4IZKA 4MYTA 1EI1A 1S4EA 2PO0B 3ZZTA 1N32I 4B3TE 5K36B 2E5LI 4DV2E 2NN6F 5FLXQ 4KHPI 4JI5E 5LMNE 5K36A 2Z5EA 5K36C 4DUZE 4M1KA 1BKNA 2ZITA 2BA1G 4B3SE 2AJ4A 1PKPA 2BM1A 1E3HA 1PIEA 4X66I 2UXCI 2UUBE 3L7ZB 5K36D 4OX9I 4OO1A 4WUCA 4OO1C 1QZRA 5EL9A 3L7ZA 1XHKA 4HY1A 1XNRE 1XMOE 4YY3I 3ZKDA 2J7KA 2GO4A 2UUAE 3UHMA 4UT4A 2GO3A 4OO1D 1FJGI 2VF3A 3P3GA 2A2DA 1J5EI 4X65I 5L3JA 1XMQI 3PS1A 2HHHI 1FWKA 2UXBE 1K47A 4LCGA 1IBLI 2VQFE 1B62A 3HKMA 3CDIA 1FWLA 1R6MA 1N36E 2C39A 4B3ME 2ZBKB 2O3ZA 4DV2I 1DARA 4DV4E 5DNLA 1NZ0A 3Q6MA 2V2ZA 2Z5BB 4B3SI 2IOQA 3P06A 4YHHI 4DU7A 5LMUE 4KHPE 2UUBI 4IZJD 3U1KA 1FNMA 4ZVIA 3J80C 1XNRI 1Z5AA 4DPXA 4MU0A 4DV5E 2UUAI 4AIMA 3WU4A 1IBKI 2WP8B 4ISAA 5DRQA 2NN6B 4HACB 4FW3A 2UXCE 4EMDA 4U3DA 1ZXNA 3M85D
chains in the Genus database with same CATH topology
4LCHA 5DROA 3P76A 3PS1A 3PS2A 4OZEA 3NZKA 1P42A 4LCGA 4FW6A 4LCFA 4OKGA 2IESA 2IERA 5DRRA 2VESA 3U1YA 4J3DA 2GO4A 3P3CA 2JT2A 1YH8A 3UHMA 1YHCA 4FW7A 4MDTA 1XXEA 2GO3A 2O3ZA 4U3BA 5DRPA 3PS3A 4ISAA 5DRQA 4FW5A 4FW3A 3P3GA 3P3EA 4FW4A 2J65A 4U3DA 4IS9A 4MQYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LCH A;  5DRO A;  3P76 A;  3PS1 A;  3PS2 A;  4OZE A;  3NZK A;  1P42 A;  4LCG A;  4FW6 A;  4LCF A;  4OKG A;  2IES A;  2IER A;  5DRR A;  2VES A;  3U1Y A;  4J3D A;  2GO4 A;  3P3C A;  2JT2 A;  1YH8 A;  3UHM A;  1YHC A;  4FW7 A;  4MDT A;  1XXE A;  2GO3 A;  2O3Z A;  4U3B A;  5DRP A;  3PS3 A;  4ISA A;  5DRQ A;  4FW5 A;  4FW3 A;  3P3G A;  3P3E A;  4FW4 A;  2J65 A;  4U3D A;  4IS9 A;  4MQY A; 
#chains in the Genus database with same CATH topology
 5C0X E;  4IFD F;  1OYS A;  4HAC A;  5IT9 C;  2NN6 C;  2WW4 A;  4DR5 E;  4FWH A;  4PRX A;  4YY3 E;  1B63 A;  1HNW E;  4LF5 I;  1PVG A;  2VES A;  2HKJ A;  2VQF I;  4KQV A;  1H74 A;  4FW7 A;  1KTV A;  5IT9 Q;  3T1H I;  3JAM C;  4AQY E;  4U3B A;  1NHI A;  1IBM E;  4X65 E;  1Z0B A;  1U2R A;  3P3E A;  4MU3 A;  2CZ9 A;  5JEA E;  1IBL E;  4GKK E;  4JYA E;  4DV4 I;  3PS2 A;  4JI2 E;  3QT8 A;  3JAM Q;  1KIJ A;  1Z5C A;  2IER A;  1Y60 A;  4LOM A;  2UUC E;  3H4L A;  5LMU I;  2NN6 E;  1ZM9 A;  2F1D A;  1N0V C;  4DV3 I;  2IOP A;  4DR3 I;  2BA1 D;  3T1Y E;  4P52 A;  1Z5B A;  4DV1 E;  4DV5 I;  2HFS A;  4OO1 B;  3HUL A;  4YHH E;  1UDQ A;  3K1J A;  1VI7 A;  4DR4 E;  2JE6 A;  4DR5 I;  1H73 A;  1MX0 A;  1N0U A;  3PYE A;  2CGE A;  4WUD A;  1HNW I;  1YHC A;  1IBK E;  3GCM A;  5EKW A;  1ZM4 A;  4DPT A;  1OJ4 A;  2Z5C A;  2BA0 D;  4AQY I;  4Z7Y A;  1IBM I;  4JI8 E;  2PNM A;  4LF5 E;  5K36 E;  1Y4S A;  4DU8 A;  4GKK I;  4JYA I;  1FI4 A;  3M7N D;  4JI2 I;  4LF7 E;  3B82 A;  2C39 B;  3F0N A;  1WUU A;  3T1H E;  1ZM3 A;  1H7U A;  4IFD A;  3WU5 A;  4IFD C;  4MDT A;  4HXZ A;  4JV5 E;  4FWG A;  3PRY A;  1UDO A;  4OO1 E;  2UUC I;  1Z0C A;  4IZJ B;  2JEA B;  3KRN A;  2WNR A;  1USV A;  4LFB I;  4IZJ A;  4USM A;  4JI4 E;  3T1Y I;  4IFD D;  4BA1 A;  2JEA A;  3P76 A;  4I3H A;  4OZE A;  4K0K E;  1Y6Z A;  4DV1 I;  2BM0 A;  4URL A;  3M6A A;  1ZXM A;  4DV3 E;  4DR3 E;  4ED4 A;  4DR4 I;  2V34 A;  2R42 A;  3WU6 A;  3K85 A;  1HNZ E;  4FW9 A;  1H7S A;  3B78 A;  3B8H A;  4DR2 E;  4DUY E;  4B3R E;  4X64 E;  1S16 A;  4IS9 A;  3LNU A;  4DR1 E;  3ZZ0 A;  4DPW A;  4MU4 A;  3OTO E;  3J80 Q;  2HFU A;  4LCF A;  1RHY A;  4JI8 I;  2O1U A;  1OYR A;  1Z0E A;  4MYU A;  4DV6 I;  3J7A M;  2PNL A;  4LFC E;  3QT5 A;  4N3O A;  3Q6N A;  1RR9 A;  2GQ0 A;  2BR2 B;  1VIS A;  2GS8 A;  4LF7 I;  4GKJ I;  2BR2 A;  1XNQ E;  4DPU A;  2JEB B;  2O1V A;  2Q2E B;  3M85 G;  1E3P A;  5C0X F;  3DD6 A;  4JV5 I;  4P7A A;  2DEI A;  3J7A G;  2JEB A;  2F4V I;  5LL6 R;  4LFA I;  5BR8 E;  3QT7 A;  2X36 A;  2C37 A;  3NZK A;  1Z0W A;  4JI4 I;  2V2Q A;  5A2Q C;  4K0K I;  4JI0 I;  1I94 I;  4MU1 A;  2LJP A;  1USU A;  1XXE A;  3J81 C;  3Q1Q A;  4NXM E;  5DRP A;  3CWV A;  4LFB E;  2O1W A;  5JEA F;  5FLX C;  4LF9 E;  2J65 A;  3PYD A;  4DR7 E;  1HNZ I;  4LF6 E;  4Z7C A;  5A2Q Q;  4JI1 E;  4BA2 B;  5DRO A;  4DR2 I;  4X62 I;  4DUY I;  4B3R I;  2OI2 A;  3LTO A;  4PU9 A;  4X64 I;  4BA2 A;  4DR1 I;  2JE6 B;  4DV0 E;  3J81 Q;  4DR6 E;  4OKG A;  2BV3 A;  1FKA E;  4QNJ A;  3OTO I;  2PO0 A;  4DV7 I;  4J3D A;  1KKH A;  2JT2 A;  1MU5 A;  3LPS A;  2Z5C B;  4R1F A;  4UTG A;  4LFC I;  1EA6 A;  4DXL A;  3PYF A;  5IWA I;  4LPF A;  4JI3 I;  1XNQ I;  2ZM6 E;  4DV6 E;  5FWK A;  1P42 A;  5BR8 I;  4IFD B;  4JI6 I;  2O1T A;  4JI7 I;  4LF8 E;  1HNX E;  2PNZ B;  4GKJ E;  5GME A;  3PYG A;  2PO2 B;  2UXD E;  2XEX A;  4AID A;  1ELO A;  1HR0 E;  2PNZ A;  4FWD A;  4XTJ A;  2V2V A;  2WNR B;  2PO2 A;  2F4V E;  2BA0 G;  4LFA E;  4FW4 A;  4BA1 B;  4NXM I;  2CVE A;  2UU9 I;  1ZM2 A;  2CG9 A;  5K36 F;  3CDJ A;  1KVK A;  3D4J A;  4JG4 A;  4LF9 I;  4DR7 I;  4FW6 A;  5C0X B;  4JI1 I;  4JI0 E;  4LF6 I;  3M7N G;  1UDN A;  2A2C A;  2EFG A;  4HYM A;  1I94 E;  5DRR A;  4WUB A;  5C0X A;  2VQE E;  1N34 E;  5C0X C;  3GON A;  3HJC A;  4USK A;  4DV0 I;  4DR6 I;  4B3T I;  1MG7 A;  3V5R A;  4OO1 F;  5DNX A;  4LF4 E;  4NXN E;  4JI5 I;  5LMN I;  1N33 E;  2HK2 A;  4RPF A;  4DUZ I;  4FW5 A;  1NHH A;  4X62 E;  1NHJ A;  2HK3 A;  5C0X D;  4MQY A;  1N32 E;  4IFD E;  2X7I A;  4AM3 A;  2E5L E;  2V8P A;  1Z0G A;  2Z5B A;  5JEA B;  3GLL A;  3ZZU A;  4DV7 E;  2ZM6 I;  4PRV A;  3GME A;  5JEA A;  3WU3 A;  2PO1 B;  5JEA C;  3U1Y A;  3V2U C;  1Y4U A;  1HK7 A;  2PO1 A;  5IWA E;  1XMO I;  3B4T A;  3H1C A;  4LF8 I;  1HNX I;  1UDS A;  2HKE A;  4JI3 E;  3PS3 A;  4X66 E;  1Z0V A;  1Y5Y A;  2C38 B;  2UXD I;  3ZKB A;  3ZM7 A;  1A6F A;  5JEA D;  1HR0 I;  4OX9 E;  2WP8 A;  4LCH A;  2NN6 A;  2C37 B;  1R6L A;  2C38 A;  5ELW A;  2E1R A;  4JI6 E;  1Z59 A;  4QNK A;  4JI7 E;  3QT6 A;  2IES A;  1UEK A;  4NBQ A;  2UXB I;  1H72 C;  1RRE A;  3P3C A;  1FJG E;  2NN6 D;  1YH8 A;  4FN5 A;  1J5E E;  2VQE I;  1D6T A;  1OYP A;  2AE8 A;  1N34 I;  4DPY A;  1N36 I;  4B3M I;  1XMQ E;  5GMD A;  2UU9 E;  2HHH E;  1Z0T A;  2NPF A;  4IZK B;  4LF4 I;  3K17 A;  4NXN I;  2DEJ A;  1N33 I;  4GQU A;  2R3V A;  4IZK A;  4MYT A;  1EI1 A;  1S4E A;  2PO0 B;  3ZZT A;  1N32 I;  4B3T E;  5K36 B;  2E5L I;  4DV2 E;  2NN6 F;  5FLX Q;  4KHP I;  4JI5 E;  5LMN E;  5K36 A;  2Z5E A;  5K36 C;  4DUZ E;  4M1K A;  1BKN A;  2ZIT A;  2BA1 G;  4B3S E;  2AJ4 A;  1PKP A;  2BM1 A;  1E3H A;  1PIE A;  4X66 I;  2UXC I;  2UUB E;  3L7Z B;  5K36 D;  4OX9 I;  4OO1 A;  4WUC A;  4OO1 C;  1QZR A;  5EL9 A;  3L7Z A;  1XHK A;  4HY1 A;  1XNR E;  1XMO E;  4YY3 I;  3ZKD A;  2J7K A;  2GO4 A;  2UUA E;  3UHM A;  4UT4 A;  2GO3 A;  4OO1 D;  1FJG I;  2VF3 A;  3P3G A;  2A2D A;  1J5E I;  4X65 I;  5L3J A;  1XMQ I;  3PS1 A;  2HHH I;  1FWK A;  2UXB E;  1K47 A;  4LCG A;  1IBL I;  2VQF E;  1B62 A;  3HKM A;  3CDI A;  1FWL A;  1R6M A;  1N36 E;  2C39 A;  4B3M E;  2ZBK B;  2O3Z A;  4DV2 I;  1DAR A;  4DV4 E;  5DNL A;  1NZ0 A;  3Q6M A;  2V2Z A;  2Z5B B;  4B3S I;  2IOQ A;  3P06 A;  4YHH I;  4DU7 A;  5LMU E;  4KHP E;  2UUB I;  4IZJ D;  3U1K A;  1FNM A;  4ZVI A;  3J80 C;  1XNR I;  1Z5A A;  4DPX A;  4MU0 A;  4DV5 E;  2UUA I;  4AIM A;  3WU4 A;  1IBK I;  2WP8 B;  4ISA A;  5DRQ A;  2NN6 B;  4HAC B;  4FW3 A;  2UXC E;  4EMD A;  4U3D A;  1ZXN A;  3M85 D; 
#chains in the Genus database with same CATH homology
 4LCH A;  5DRO A;  3P76 A;  3PS1 A;  3PS2 A;  4OZE A;  3NZK A;  1P42 A;  4LCG A;  4FW6 A;  4LCF A;  4OKG A;  2IES A;  2IER A;  5DRR A;  2VES A;  3U1Y A;  4J3D A;  2GO4 A;  3P3C A;  2JT2 A;  1YH8 A;  3UHM A;  1YHC A;  4FW7 A;  4MDT A;  1XXE A;  2GO3 A;  2O3Z A;  4U3B A;  5DRP A;  3PS3 A;  4ISA A;  5DRQ A;  4FW5 A;  4FW3 A;  3P3G A;  3P3E A;  4FW4 A;  2J65 A;  4U3D A;  4IS9 A;  4MQY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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