3NZKA

Structure of lpxc from yersinia enterocolitica complexed with chir090 inhibitor
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
298
structure length
298
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTIDFNHPAIDSSTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090 .
pubmed doi rcsb
molecule tags Hydrolase
source organism Yersinia enterocolitica
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 94
structure length 298
sequence length 298
chains with identical sequence B
ec nomenclature ec 3.5.1.33: N-acetylglucosamine deacetylase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3nzkA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3nzkA02
3PS1A 3P76A 5DROA 4FW7A 4LCHA 3NZKA 2JT2A 4LCFA 4FW5A 4OKGA 3UHMA 3P3GA 2GO3A 4J3DA 4ISAA 2IERA 5DRRA 4U3BA 3U1YA 1YHCA 4FW4A 2IESA 1YH8A 5DRPA 4IS9A 2O3ZA 4MDTA 2J65A 1P42A 5DRQA 3PS3A 1XXEA 3PS2A 3P3EA 4MQYA 4FW3A 4FW6A 3P3CA 4OZEA 4U3DA 2GO4A 2VESA 4LCGA
chains in the Genus database with same CATH superfamily
3PYGA 4FWDA 5LL6R 4YHHI 4JI2I 1KKHA 2JEAB 4DV5I 2BA1G 3ZZ0A 1FI4A 1Y6ZA 4OO1F 4B3SE 4LF6E 2UXDE 3ZKBA 4U3BA 4B3MI 1FWKA 2JE6A 4DV0E 4IFDE 4LF7I 2BR2B 4LPFA 5DNLA 1XMOI 4LF5I 5IT9C 4WUDA 5FLXQ 1XXEA 1H7SA 4DR2E 3J80C 4DV1I 3L7ZA 5JEAC 4DR3I 2UXBE 4LF9E 1PKPA 5LMNI 5C0XC 1FWLA 4UTGA 5K36C 1HNWE 5BR8E 3M6AA 2JT2A 1HR0I 2GO3A 4DV6E 2E1RA 4JI7E 3WU4A 3Q6MA 3JAMQ 1Y60A 4NXMI 2WNRA 1S4EA 4FW4A 1YH8A 2R3VA 5FWKA 4LF8I 1H7UA 4JI1I 2DEIA 4AQYE 1PVGA 1D6TA 4YY3I 4DUYE 4PU9A 1XNRE 1A6FA 4B3TI 4M1KA 1XMQI 2PO1A 1B62A 3PS1A 4AM3A 4MYTA 2NN6F 4X66I 4OO1B 3NZKA 2HFUA 3P3GA 1RREA 4JI5I 1OYRA 5DRRA 2JEAA 5JEAD 4WUCA 4IFDB 2NPFA 2E5LE 2WW4A 4ED4A 3HULA 4DPWA 1ZM9A 2BR2A 4K0KE 4FW9A 2NN6C 2Z5BB 3GONA 3P3CA 4JG4A 4I3HA 5IT9Q 1N0VC 4BA2B 1RR9A 2PO2B 4DU7A 4GKKE 1NZ0A 4LFCI 1N33E 1Y4SA 2R42A 3V2UC 3OTOI 2A2CA 3J7AM 4JYAI 3ZZUA 4DUZE 4Z7CA 2UXCE 2V8PA 4PRXA 2HFSA 3WU3A 1E3HA 4MQYA 3T1YI 1J5EE 2A2DA 2ZITA 4XTJA 1IBKE 1OYPA 4GQUA 4DPYA 1ZM3A 2AJ4A 4JI4E 1FKAE 1Y4UA 1WUUA 4JI6E 1N32I 2CG9A 2UUBI 4OKGA 4LFAI 4JV5I 3PYFA 4DR1E 3QT8A 4DV3E 4DR4E 4OX9E 3LPSA 4DV2I 1I94E 2UUCE 4OO1A 1UDOA 1S16A 1KTVA 1MU5A 2F4VE 1ZM4A 4B3RI 4IFDA 5GMDA 4NBQA 4KQVA 4DPXA 3M7ND 3WU6A 4U3DA 5A2QC 4PRVA 4DR7E 3WU5A 2BM0A 2C37B 1Z0BA 4B3SI 2C39B 1UDQA 2Z5BA 2GQ0A 3PYDA 4FW7A 5C0XE 4OO1E 4HXZA 4X64E 2V34A 2PNLA 5JEAF 2BM1A 4BA2A 2J7KA 5K36E 5C0XF 2PO2A 5ELWA 3CDJA 4DV0I 1VI7A 4N3OA 4DR6E 4WUBA 4USMA 5K36F 1XHKA 1ELOA 3Q1QA 2VQFE 2UUAE 4DR2I 2J65A 2UU9I 4LF9I 3HKMA 3PRYA 4Z7YA 4MU3A 5BR8I 1HNWI 4QNJA 3QT5A 1DARA 4DV6I 4YHHE 4LCHA 4GKJI 4JI2E 4P52A 2C38B 1NHHA 3U1YA 4DR5E 1KVKA 4DUYI 4LF5E 1H74A 5L3JA 3QT7A 3T1HE 1MX0A 4FW6A 2IOPA 2VF3A 2JEBB 4DR3E 5DNXA 2NN6E 4IZJB 5LMNE 3J81C 3P76A 4BA1B 5JEAB 4HYMA 5C0XB 4DV7E 3GLLA 2C37A 2IERA 1QZRA 1HR0E 3U1KA 2C39A 2PNMA 5K36B 4NXME 3K1JA 4MDTA 1R6LA 3PS3A 4K0KI 4LF8E 1Z0WA 4USKA 3M7NG 1FJGE 1N34E 1R6MA 5EKWA 2GO4A 4B3TE 4NXNE 1Y5YA 1E3PA 1Z0CA 1OJ4A 2O1WA 4LFBE 1N33I 1HNZE 4X62E 3GMEA 3F0NA 3J80Q 1IBME 1NHJA 4JI5E 4DV4I 1FNMA 4LF4E 4DUZI 2UXCI 3GCMA 2C38A 5GMEA 2PNZB 4MU0A 1U2RA 1P42A 4QNKA 3PS2A 1J5EI 1BKNA 4IFDD 1IBKI 1K47A 1UDNA 2VQEI 2HKEA 2PO0B 2OI2A 4LCGA 3LNUA 4JI4I 4JI6I 3PYEA 1XNQE 1IBLI 2V2QA 4IZKB 4DR1I 2NN6B 4DV3I 4LCFA 5FLXC 4OX9I 4DR4I 4LOMA 2JEBA 5IWAI 4ISAA 4JI0E 4IZJA 4X65I 5LMUE 2ZM6E 4BA1A 2XEXA 5JEAA 5C0XA 2F4VI 2IESA 1ZXNA 5K36A 3J7AG 4MU1A 2ZBKB 1MG7A 2HKJA 1Z5AA 4AIMA 5DROA 5JEAE 1N36E 3M85G 2HHHE 4LF6I 2UXDI 1Z0VA 4EMDA 2Q2EB 4JI3E 4MU4A 4AIDA 2UUAI 4RPFA 4JI8E 2O3ZA 2CGEA 1VISA 2PNZA 2UXBI 4B3RE 2Z5EA 4KHPE 5EL9A 1Z5CA 2AE8A 2CVEA 1ZXMA 2GS8A 4P7AA 2PO0A 1HNXE 3D4JA 4JI7I 4DV5E 3K17A 4DR5I 4IZKA 2NN6A 2Z5CB 3ZKDA 1EA6A 4IS9A 3H1CA 4B3ME 1PIEA 4AQYI 3T1HI 4IFDF 2DEJA 4LF7E 1XNRI 1XMOE 2UU9E 2X7IA 4FW3A 3LTOA 4FN5A 4OO1C 4DV1E 3CWVA 4DV7I 4FWHA 4FW5A 1EI1A 4GKJE 2LJPA 4HY1A 4DPUA 3M85D 4DXLA 4IFDC 5A2QQ 2E5LI 2BV3A 2F1DA 4DU8A 4UT4A 1FJGI 2V2ZA 1H73A 1N34I 1Z59A 1USUA 3P3EA 4JI1E 1H72C 3ZM7A 3P06A 4NXNI 1HK7A 4YY3E 2WP8B 4LFBI 3K85A 2VESA 4GKKI 1UDSA 1HNZI 1XMQE 3B78A 3CDIA 4ZVIA 4X62I 2BA0G 1IBMI 4DPTA 2BA1D 3HJCA 4HACB 4FWGA 4IZJD 4X66E 4LF4I 3ZZTA 2EFGA 1OYSA 4OO1D 2O1UA 5C0XD 1NHIA 3B8HA 1Z5BA 5K36D 4MYUA 2Z5CA 2IOQA 3B4TA 3H4LA 1USVA 1XNQI 4URLA 1ZM2A 3B82A 2X36A 3V5RA 1N0UA 4JI0I 5LMUI 2O1TA 2ZM6I 2JE6B 2UUCI 1I94I 4LFCE 3OTOE 5DRPA 4DV4E 3J81Q 4JYAE 3L7ZB 1RHYA 3QT6A 3KRNA 4DR7I 2HK3A 3T1YE 2VQEE 1Z0EA 3JAMC 1N36I 2HHHI 4X64I 4JI3I 2WP8A 1IBLE 2WNRB 3UHMA 2BA0D 4J3DA 4DR6I 4R1FA 2NN6D 5IWAE 4JI8I 2UUBE 4LFAE 1N32E 4JV5E 4X65E 1Z0GA 2VQFI 1YHCA 4HACA 4DV2E 2HK2A 5DRQA 1UEKA 1B63A 2PO1B 4KHPI 3Q6NA 1KIJA 2CZ9A 3DD6A 1Z0TA 4OZEA 2V2VA 1HNXI 2O1VA
chains in the Genus database with same CATH topology
3PS1A 3P76A 5DROA 4FW7A 4LCHA 3NZKA 2JT2A 4LCFA 4FW5A 4OKGA 3UHMA 3P3GA 2GO3A 4J3DA 4ISAA 2IERA 5DRRA 4U3BA 3U1YA 1YHCA 4FW4A 2IESA 1YH8A 5DRPA 4IS9A 2O3ZA 4MDTA 2J65A 1P42A 5DRQA 3PS3A 1XXEA 3PS2A 3P3EA 4MQYA 4FW3A 4FW6A 3P3CA 4OZEA 4U3DA 2GO4A 2VESA 4LCGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PS1 A;  3P76 A;  5DRO A;  4FW7 A;  4LCH A;  3NZK A;  2JT2 A;  4LCF A;  4FW5 A;  4OKG A;  3UHM A;  3P3G A;  2GO3 A;  4J3D A;  4ISA A;  2IER A;  5DRR A;  4U3B A;  3U1Y A;  1YHC A;  4FW4 A;  2IES A;  1YH8 A;  5DRP A;  4IS9 A;  2O3Z A;  4MDT A;  2J65 A;  1P42 A;  5DRQ A;  3PS3 A;  1XXE A;  3PS2 A;  3P3E A;  4MQY A;  4FW3 A;  4FW6 A;  3P3C A;  4OZE A;  4U3D A;  2GO4 A;  2VES A;  4LCG A; 
#chains in the Genus database with same CATH topology
 3PYG A;  4FWD A;  5LL6 R;  4YHH I;  4JI2 I;  1KKH A;  2JEA B;  4DV5 I;  2BA1 G;  3ZZ0 A;  1FI4 A;  1Y6Z A;  4OO1 F;  4B3S E;  4LF6 E;  2UXD E;  3ZKB A;  4U3B A;  4B3M I;  1FWK A;  2JE6 A;  4DV0 E;  4IFD E;  4LF7 I;  2BR2 B;  4LPF A;  5DNL A;  1XMO I;  4LF5 I;  5IT9 C;  4WUD A;  5FLX Q;  1XXE A;  1H7S A;  4DR2 E;  3J80 C;  4DV1 I;  3L7Z A;  5JEA C;  4DR3 I;  2UXB E;  4LF9 E;  1PKP A;  5LMN I;  5C0X C;  1FWL A;  4UTG A;  5K36 C;  1HNW E;  5BR8 E;  3M6A A;  2JT2 A;  1HR0 I;  2GO3 A;  4DV6 E;  2E1R A;  4JI7 E;  3WU4 A;  3Q6M A;  3JAM Q;  1Y60 A;  4NXM I;  2WNR A;  1S4E A;  4FW4 A;  1YH8 A;  2R3V A;  5FWK A;  4LF8 I;  1H7U A;  4JI1 I;  2DEI A;  4AQY E;  1PVG A;  1D6T A;  4YY3 I;  4DUY E;  4PU9 A;  1XNR E;  1A6F A;  4B3T I;  4M1K A;  1XMQ I;  2PO1 A;  1B62 A;  3PS1 A;  4AM3 A;  4MYT A;  2NN6 F;  4X66 I;  4OO1 B;  3NZK A;  2HFU A;  3P3G A;  1RRE A;  4JI5 I;  1OYR A;  5DRR A;  2JEA A;  5JEA D;  4WUC A;  4IFD B;  2NPF A;  2E5L E;  2WW4 A;  4ED4 A;  3HUL A;  4DPW A;  1ZM9 A;  2BR2 A;  4K0K E;  4FW9 A;  2NN6 C;  2Z5B B;  3GON A;  3P3C A;  4JG4 A;  4I3H A;  5IT9 Q;  1N0V C;  4BA2 B;  1RR9 A;  2PO2 B;  4DU7 A;  4GKK E;  1NZ0 A;  4LFC I;  1N33 E;  1Y4S A;  2R42 A;  3V2U C;  3OTO I;  2A2C A;  3J7A M;  4JYA I;  3ZZU A;  4DUZ E;  4Z7C A;  2UXC E;  2V8P A;  4PRX A;  2HFS A;  3WU3 A;  1E3H A;  4MQY A;  3T1Y I;  1J5E E;  2A2D A;  2ZIT A;  4XTJ A;  1IBK E;  1OYP A;  4GQU A;  4DPY A;  1ZM3 A;  2AJ4 A;  4JI4 E;  1FKA E;  1Y4U A;  1WUU A;  4JI6 E;  1N32 I;  2CG9 A;  2UUB I;  4OKG A;  4LFA I;  4JV5 I;  3PYF A;  4DR1 E;  3QT8 A;  4DV3 E;  4DR4 E;  4OX9 E;  3LPS A;  4DV2 I;  1I94 E;  2UUC E;  4OO1 A;  1UDO A;  1S16 A;  1KTV A;  1MU5 A;  2F4V E;  1ZM4 A;  4B3R I;  4IFD A;  5GMD A;  4NBQ A;  4KQV A;  4DPX A;  3M7N D;  3WU6 A;  4U3D A;  5A2Q C;  4PRV A;  4DR7 E;  3WU5 A;  2BM0 A;  2C37 B;  1Z0B A;  4B3S I;  2C39 B;  1UDQ A;  2Z5B A;  2GQ0 A;  3PYD A;  4FW7 A;  5C0X E;  4OO1 E;  4HXZ A;  4X64 E;  2V34 A;  2PNL A;  5JEA F;  2BM1 A;  4BA2 A;  2J7K A;  5K36 E;  5C0X F;  2PO2 A;  5ELW A;  3CDJ A;  4DV0 I;  1VI7 A;  4N3O A;  4DR6 E;  4WUB A;  4USM A;  5K36 F;  1XHK A;  1ELO A;  3Q1Q A;  2VQF E;  2UUA E;  4DR2 I;  2J65 A;  2UU9 I;  4LF9 I;  3HKM A;  3PRY A;  4Z7Y A;  4MU3 A;  5BR8 I;  1HNW I;  4QNJ A;  3QT5 A;  1DAR A;  4DV6 I;  4YHH E;  4LCH A;  4GKJ I;  4JI2 E;  4P52 A;  2C38 B;  1NHH A;  3U1Y A;  4DR5 E;  1KVK A;  4DUY I;  4LF5 E;  1H74 A;  5L3J A;  3QT7 A;  3T1H E;  1MX0 A;  4FW6 A;  2IOP A;  2VF3 A;  2JEB B;  4DR3 E;  5DNX A;  2NN6 E;  4IZJ B;  5LMN E;  3J81 C;  3P76 A;  4BA1 B;  5JEA B;  4HYM A;  5C0X B;  4DV7 E;  3GLL A;  2C37 A;  2IER A;  1QZR A;  1HR0 E;  3U1K A;  2C39 A;  2PNM A;  5K36 B;  4NXM E;  3K1J A;  4MDT A;  1R6L A;  3PS3 A;  4K0K I;  4LF8 E;  1Z0W A;  4USK A;  3M7N G;  1FJG E;  1N34 E;  1R6M A;  5EKW A;  2GO4 A;  4B3T E;  4NXN E;  1Y5Y A;  1E3P A;  1Z0C A;  1OJ4 A;  2O1W A;  4LFB E;  1N33 I;  1HNZ E;  4X62 E;  3GME A;  3F0N A;  3J80 Q;  1IBM E;  1NHJ A;  4JI5 E;  4DV4 I;  1FNM A;  4LF4 E;  4DUZ I;  2UXC I;  3GCM A;  2C38 A;  5GME A;  2PNZ B;  4MU0 A;  1U2R A;  1P42 A;  4QNK A;  3PS2 A;  1J5E I;  1BKN A;  4IFD D;  1IBK I;  1K47 A;  1UDN A;  2VQE I;  2HKE A;  2PO0 B;  2OI2 A;  4LCG A;  3LNU A;  4JI4 I;  4JI6 I;  3PYE A;  1XNQ E;  1IBL I;  2V2Q A;  4IZK B;  4DR1 I;  2NN6 B;  4DV3 I;  4LCF A;  5FLX C;  4OX9 I;  4DR4 I;  4LOM A;  2JEB A;  5IWA I;  4ISA A;  4JI0 E;  4IZJ A;  4X65 I;  5LMU E;  2ZM6 E;  4BA1 A;  2XEX A;  5JEA A;  5C0X A;  2F4V I;  2IES A;  1ZXN A;  5K36 A;  3J7A G;  4MU1 A;  2ZBK B;  1MG7 A;  2HKJ A;  1Z5A A;  4AIM A;  5DRO A;  5JEA E;  1N36 E;  3M85 G;  2HHH E;  4LF6 I;  2UXD I;  1Z0V A;  4EMD A;  2Q2E B;  4JI3 E;  4MU4 A;  4AID A;  2UUA I;  4RPF A;  4JI8 E;  2O3Z A;  2CGE A;  1VIS A;  2PNZ A;  2UXB I;  4B3R E;  2Z5E A;  4KHP E;  5EL9 A;  1Z5C A;  2AE8 A;  2CVE A;  1ZXM A;  2GS8 A;  4P7A A;  2PO0 A;  1HNX E;  3D4J A;  4JI7 I;  4DV5 E;  3K17 A;  4DR5 I;  4IZK A;  2NN6 A;  2Z5C B;  3ZKD A;  1EA6 A;  4IS9 A;  3H1C A;  4B3M E;  1PIE A;  4AQY I;  3T1H I;  4IFD F;  2DEJ A;  4LF7 E;  1XNR I;  1XMO E;  2UU9 E;  2X7I A;  4FW3 A;  3LTO A;  4FN5 A;  4OO1 C;  4DV1 E;  3CWV A;  4DV7 I;  4FWH A;  4FW5 A;  1EI1 A;  4GKJ E;  2LJP A;  4HY1 A;  4DPU A;  3M85 D;  4DXL A;  4IFD C;  5A2Q Q;  2E5L I;  2BV3 A;  2F1D A;  4DU8 A;  4UT4 A;  1FJG I;  2V2Z A;  1H73 A;  1N34 I;  1Z59 A;  1USU A;  3P3E A;  4JI1 E;  1H72 C;  3ZM7 A;  3P06 A;  4NXN I;  1HK7 A;  4YY3 E;  2WP8 B;  4LFB I;  3K85 A;  2VES A;  4GKK I;  1UDS A;  1HNZ I;  1XMQ E;  3B78 A;  3CDI A;  4ZVI A;  4X62 I;  2BA0 G;  1IBM I;  4DPT A;  2BA1 D;  3HJC A;  4HAC B;  4FWG A;  4IZJ D;  4X66 E;  4LF4 I;  3ZZT A;  2EFG A;  1OYS A;  4OO1 D;  2O1U A;  5C0X D;  1NHI A;  3B8H A;  1Z5B A;  5K36 D;  4MYU A;  2Z5C A;  2IOQ A;  3B4T A;  3H4L A;  1USV A;  1XNQ I;  4URL A;  1ZM2 A;  3B82 A;  2X36 A;  3V5R A;  1N0U A;  4JI0 I;  5LMU I;  2O1T A;  2ZM6 I;  2JE6 B;  2UUC I;  1I94 I;  4LFC E;  3OTO E;  5DRP A;  4DV4 E;  3J81 Q;  4JYA E;  3L7Z B;  1RHY A;  3QT6 A;  3KRN A;  4DR7 I;  2HK3 A;  3T1Y E;  2VQE E;  1Z0E A;  3JAM C;  1N36 I;  2HHH I;  4X64 I;  4JI3 I;  2WP8 A;  1IBL E;  2WNR B;  3UHM A;  2BA0 D;  4J3D A;  4DR6 I;  4R1F A;  2NN6 D;  5IWA E;  4JI8 I;  2UUB E;  4LFA E;  1N32 E;  4JV5 E;  4X65 E;  1Z0G A;  2VQF I;  1YHC A;  4HAC A;  4DV2 E;  2HK2 A;  5DRQ A;  1UEK A;  1B63 A;  2PO1 B;  4KHP I;  3Q6N A;  1KIJ A;  2CZ9 A;  3DD6 A;  1Z0T A;  4OZE A;  2V2V A;  1HNX I;  2O1V A; 
#chains in the Genus database with same CATH homology
 3PS1 A;  3P76 A;  5DRO A;  4FW7 A;  4LCH A;  3NZK A;  2JT2 A;  4LCF A;  4FW5 A;  4OKG A;  3UHM A;  3P3G A;  2GO3 A;  4J3D A;  4ISA A;  2IER A;  5DRR A;  4U3B A;  3U1Y A;  1YHC A;  4FW4 A;  2IES A;  1YH8 A;  5DRP A;  4IS9 A;  2O3Z A;  4MDT A;  2J65 A;  1P42 A;  5DRQ A;  3PS3 A;  1XXE A;  3PS2 A;  3P3E A;  4MQY A;  4FW3 A;  4FW6 A;  3P3C A;  4OZE A;  4U3D A;  2GO4 A;  2VES A;  4LCG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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