4LCHA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-051 complex
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
296
structure length
296
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/antibiotic
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 94
structure length 296
sequence length 296
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4lchA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4lchA02
4J3DA 4U3BA 4MDTA 3UHMA 3NZKA 3P3GA 2O3ZA 3PS2A 3PS1A 1XXEA 2IERA 4FW4A 5DRPA 1YH8A 2VESA 4FW6A 5DROA 2JT2A 2J65A 4ISAA 4LCFA 3U1YA 4LCHA 4OKGA 4FW3A 2IESA 2GO3A 3P3CA 4U3DA 4FW7A 4LCGA 4IS9A 2GO4A 3PS3A 5DRQA 3P76A 5DRRA 1YHCA 3P3EA 4MQYA 4OZEA 1P42A 4FW5A
chains in the Genus database with same CATH superfamily
2C39A 4NXMI 4IZKB 1N36E 3P3GA 2NPFA 4JI5E 3K17A 5BR8E 1K47A 1XXEA 3WU5A 5IT9Q 4ZVIA 4QNJA 4I3HA 1Y4SA 4AQYE 4DU7A 2AJ4A 2C37A 2CVEA 2R42A 3U1KA 4DR6I 4DR6E 1ZM3A 4JI6E 4JI7I 4IFDB 4JI8E 2O1UA 2HKEA 4WUCA 2PNLA 4DPWA 1VISA 1Z0GA 4LF8I 4OO1F 4HY1A 4J3DA 2UUBI 4OO1C 1HK7A 1QZRA 1PKPA 2JT2A 2J65A 2HKJA 3T1HI 5C0XA 1HR0I 1FNMA 3LNUA 4FN5A 4HXZA 1FI4A 4JI7E 2IESA 2NN6E 4JI6I 4GKJE 2NN6A 1N33E 5BR8I 2WW4A 4DV5I 5FWKA 1RR9A 5JEAE 5LMUI 3P3EA 3T1HE 4P7AA 4WUDA 1J5EI 4K0KE 3GMEA 5C0XF 2UUAE 4FWDA 1ZXNA 4B3RI 4DPUA 2UU9E 4ED4A 1E3HA 1N33I 3Q6MA 2IOPA 4NXNE 1N34I 2VQEE 4DV1E 1XMQE 4LOMA 3U1YA 2PO2B 4JI4I 4DV4I 5K36E 5K36D 3QT5A 3P3CA 4FW7A 4JI0E 2F1DA 4NXNI 4HACB 2X36A 4DV2I 4IFDE 2BM1A 2V2VA 4JI3E 4FW5A 1FWKA 4U3BA 3UHMA 4MDTA 3NZKA 1XNQE 1HNXI 4PRVA 4JI8I 3PS2A 3PS1A 2HFUA 2PNZB 1Y6ZA 4AM3A 4OKGA 1XMOE 1NHJA 3LTOA 4JI4E 2PO1B 3B82A 4Z7YA 4LF5E 4UTGA 3L7ZA 4IZJB 1UDSA 2GS8A 2HHHE 4OX9E 3PRYA 2IOQA 4IS9A 4DR1I 4B3SE 3ZZTA 3P76A 5DRRA 4X65E 5K36C 3ZKDA 5DRPA 1B62A 4JG4A 1IBLE 4UT4A 1R6MA 3K85A 1Z0TA 2GQ0A 1XHKA 2LJPA 2O3ZA 1Y60A 4JI0I 5LMUE 1UDOA 1HR0E 2HFSA 2E1RA 4YY3I 4GKJI 4DUYI 1HNZE 4LF7E 5JEAF 4DR3I 2GO4A 4DR2E 5DRQA 2BA1G 2R3VA 4MYTA 4LF8E 4LFBE 4FWHA 1Z5CA 4LF6I 2JEAB 1ZM4A 5LMNI 1USVA 4LPFA 5LMNE 2JEBA 1HNZI 1EA6A 4X62I 4DV4E 4LF9I 3HKMA 2CZ9A 4DR5I 2Z5BB 4QNKA 1OYPA 2GO3A 4N3OA 4U3DA 4BA1B 4B3TI 4DU8A 2ZBKB 3V5RA 1XMOI 4KQVA 1B63A 4USKA 4KHPI 4OO1B 1FKAE 2BR2A 2PO0A 3HJCA 1IBKI 2UU9I 2NN6F 4RPFA 4DUZI 1YH8A 2VESA 3H4LA 4URLA 4X66I 4LFBI 4DV3I 4DR7E 2BA0D 1Z5BA 3H1CA 4DV0I 4IZKA 3Q6NA 3JAMC 3K1JA 2C37B 2CGEA 5IWAI 1PIEA 4JI3I 3M85G 1I94I 4YHHI 1Z0EA 4PRXA 2V34A 2Z5BA 4X65I 4IFDD 4DXLA 4DUYE 4LF7I 4B3TE 1MX0A 2IERA 4BA1A 5C0XB 1KTVA 1Z0WA 4ISAA 1Z5AA 1UDNA 2CG9A 4FW3A 4AQYI 4XTJA 4B3MI 4OO1E 2V2ZA 3M6AA 5EKWA 2UXDE 4DV6I 3ZM7A 5DNLA 1N32I 4BA2B 1BKNA 1H7UA 4B3RE 1N36I 4PU9A 5LL6R 2F4VI 3B4TA 1FJGI 4DV7E 4FW9A 3V2UC 2PO2A 2JE6B 1H72C 4NXME 3JAMQ 1WUUA 2DEJA 1Y4UA 3PYDA 5JEAB 1I94E 4LCHA 3KRNA 5IWAE 1N0VC 3GONA 1HNWE 3B8HA 1D6TA 2J7KA 3QT7A 4JV5E 3PYEA 4R1FA 1YHCA 4Z7CA 4DV3E 1A6FA 5K36B 1H74A 2VQFE 1XNRE 2V2QA 2WP8B 4HACA 2PO1A 2UUCE 3CDIA 2X7IA 5DROA 2EFGA 5C0XE 3CDJA 4LFCI 1Z0BA 1E3PA 4LF4I 4X66E 3GCMA 2VQEI 2A2DA 1U2RA 2UXCE 1Y5YA 2ZM6E 4DR7I 4NBQA 3LPSA 2UUAI 1OJ4A 3M7ND 3HULA 2Z5CA 4YHHE 3M7NG 4IZJD 4DPYA 4DV2E 4LFAI 1XNRI 3DD6A 1N32E 4JV5I 1IBLI 5EL9A 3J7AM 1OYSA 2E5LE 3ZZ0A 3M85D 2VF3A 3Q1QA 3OTOE 3GLLA 1KVKA 3WU4A 3OTOI 4DR3E 4OO1A 4DV6E 4AIMA 4MYUA 2PNMA 1PVGA 5C0XD 5ELWA 4LF5I 1UDQA 4LCGA 2Z5CB 4YY3E 1XNQI 3PS3A 1Z0VA 2BA0G 1H73A 3CWVA 1ZXMA 4DV7I 1XMQI 1S4EA 2NN6B 2C38A 4MU1A 1N34E 1IBMI 4LFAE 5GMDA 2ZM6I 2UUBE 4FW6A 4M1KA 1S16A 2HHHI 4OX9I 4DR5E 1USUA 3J81Q 4P52A 1Z0CA 3PYGA 4FWGA 2JEBB 4MU3A 2JEAA 2UUCI 2HK2A 2O1VA 5JEAD 2PO0B 2BR2B 1P42A 2C38B 4DR4E 4MU0A 1N0UA 1FJGE 2UXBE 5FLXC 5FLXQ 3F0NA 2BV3A 2UXCI 1MU5A 1VI7A 1J5EE 2O1TA 5DNXA 1KIJA 4K0KI 4DV0E 4LCFA 3PYFA 5L3JA 1RHYA 4OO1D 4USMA 3WU6A 1EI1A 4GQUA 4LF9E 4JI5I 4MQYA 2E5LI 4X62E 1RREA 5GMEA 2VQFI 4AIDA 4DPXA 3L7ZB 4IZJA 2C39B 5A2QC 4DPTA 1H7SA 2NN6C 2DEIA 2OI2A 2UXDI 1FWLA 4HYMA 3WU3A 2UXBI 3J80Q 2HK3A 4DR4I 4LFCE 1NHHA 3J7AG 3QT6A 4DV1I 4GKKE 2AE8A 4IFDC 4IFDA 5K36F 3J81C 1DARA 1OYRA 4DUZE 4B3SI 2WNRA 4DR1E 3B78A 4BA2A 4WUBA 4JYAE 4JI2E 2Q2EB 1UEKA 4DV5E 2Z5EA 4DR2I 2JE6A 2NN6D 4X64I 2BM0A 4GKKI 3QT8A 3ZKBA 2XEXA 5IT9C 5JEAC 3D4JA 4EMDA 2PNZA 5JEAA 2A2CA 1KKHA 1IBKE 1MG7A 4OZEA 2WNRB 3P06A 3J80C 2BA1D 2O1WA 2F4VE 1NZ0A 4JI1I 1IBME 1ELOA 4JI1E 2V8PA 4LF6E 3T1YI 4MU4A 1R6LA 2ZITA 1ZM2A 1Z59A 4IFDF 5K36A 4X64E 1ZM9A 1NHIA 5A2QQ 3ZZUA 1HNWI 3T1YE 4LF4E 2WP8A 4B3ME 4KHPE 4JI2I 1HNXE 5C0XC 4JYAI 4FW4A
chains in the Genus database with same CATH topology
4J3DA 4U3BA 4MDTA 3UHMA 3NZKA 3P3GA 2O3ZA 3PS2A 3PS1A 1XXEA 2IERA 4FW4A 5DRPA 1YH8A 2VESA 4FW6A 5DROA 2JT2A 2J65A 4ISAA 4LCFA 3U1YA 4LCHA 4OKGA 4FW3A 2IESA 2GO3A 3P3CA 4U3DA 4FW7A 4LCGA 4IS9A 2GO4A 3PS3A 5DRQA 3P76A 5DRRA 1YHCA 3P3EA 4MQYA 4OZEA 1P42A 4FW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J3D A;  4U3B A;  4MDT A;  3UHM A;  3NZK A;  3P3G A;  2O3Z A;  3PS2 A;  3PS1 A;  1XXE A;  2IER A;  4FW4 A;  5DRP A;  1YH8 A;  2VES A;  4FW6 A;  5DRO A;  2JT2 A;  2J65 A;  4ISA A;  4LCF A;  3U1Y A;  4LCH A;  4OKG A;  4FW3 A;  2IES A;  2GO3 A;  3P3C A;  4U3D A;  4FW7 A;  4LCG A;  4IS9 A;  2GO4 A;  3PS3 A;  5DRQ A;  3P76 A;  5DRR A;  1YHC A;  3P3E A;  4MQY A;  4OZE A;  1P42 A;  4FW5 A; 
#chains in the Genus database with same CATH topology
 2C39 A;  4NXM I;  4IZK B;  1N36 E;  3P3G A;  2NPF A;  4JI5 E;  3K17 A;  5BR8 E;  1K47 A;  1XXE A;  3WU5 A;  5IT9 Q;  4ZVI A;  4QNJ A;  4I3H A;  1Y4S A;  4AQY E;  4DU7 A;  2AJ4 A;  2C37 A;  2CVE A;  2R42 A;  3U1K A;  4DR6 I;  4DR6 E;  1ZM3 A;  4JI6 E;  4JI7 I;  4IFD B;  4JI8 E;  2O1U A;  2HKE A;  4WUC A;  2PNL A;  4DPW A;  1VIS A;  1Z0G A;  4LF8 I;  4OO1 F;  4HY1 A;  4J3D A;  2UUB I;  4OO1 C;  1HK7 A;  1QZR A;  1PKP A;  2JT2 A;  2J65 A;  2HKJ A;  3T1H I;  5C0X A;  1HR0 I;  1FNM A;  3LNU A;  4FN5 A;  4HXZ A;  1FI4 A;  4JI7 E;  2IES A;  2NN6 E;  4JI6 I;  4GKJ E;  2NN6 A;  1N33 E;  5BR8 I;  2WW4 A;  4DV5 I;  5FWK A;  1RR9 A;  5JEA E;  5LMU I;  3P3E A;  3T1H E;  4P7A A;  4WUD A;  1J5E I;  4K0K E;  3GME A;  5C0X F;  2UUA E;  4FWD A;  1ZXN A;  4B3R I;  4DPU A;  2UU9 E;  4ED4 A;  1E3H A;  1N33 I;  3Q6M A;  2IOP A;  4NXN E;  1N34 I;  2VQE E;  4DV1 E;  1XMQ E;  4LOM A;  3U1Y A;  2PO2 B;  4JI4 I;  4DV4 I;  5K36 E;  5K36 D;  3QT5 A;  3P3C A;  4FW7 A;  4JI0 E;  2F1D A;  4NXN I;  4HAC B;  2X36 A;  4DV2 I;  4IFD E;  2BM1 A;  2V2V A;  4JI3 E;  4FW5 A;  1FWK A;  4U3B A;  3UHM A;  4MDT A;  3NZK A;  1XNQ E;  1HNX I;  4PRV A;  4JI8 I;  3PS2 A;  3PS1 A;  2HFU A;  2PNZ B;  1Y6Z A;  4AM3 A;  4OKG A;  1XMO E;  1NHJ A;  3LTO A;  4JI4 E;  2PO1 B;  3B82 A;  4Z7Y A;  4LF5 E;  4UTG A;  3L7Z A;  4IZJ B;  1UDS A;  2GS8 A;  2HHH E;  4OX9 E;  3PRY A;  2IOQ A;  4IS9 A;  4DR1 I;  4B3S E;  3ZZT A;  3P76 A;  5DRR A;  4X65 E;  5K36 C;  3ZKD A;  5DRP A;  1B62 A;  4JG4 A;  1IBL E;  4UT4 A;  1R6M A;  3K85 A;  1Z0T A;  2GQ0 A;  1XHK A;  2LJP A;  2O3Z A;  1Y60 A;  4JI0 I;  5LMU E;  1UDO A;  1HR0 E;  2HFS A;  2E1R A;  4YY3 I;  4GKJ I;  4DUY I;  1HNZ E;  4LF7 E;  5JEA F;  4DR3 I;  2GO4 A;  4DR2 E;  5DRQ A;  2BA1 G;  2R3V A;  4MYT A;  4LF8 E;  4LFB E;  4FWH A;  1Z5C A;  4LF6 I;  2JEA B;  1ZM4 A;  5LMN I;  1USV A;  4LPF A;  5LMN E;  2JEB A;  1HNZ I;  1EA6 A;  4X62 I;  4DV4 E;  4LF9 I;  3HKM A;  2CZ9 A;  4DR5 I;  2Z5B B;  4QNK A;  1OYP A;  2GO3 A;  4N3O A;  4U3D A;  4BA1 B;  4B3T I;  4DU8 A;  2ZBK B;  3V5R A;  1XMO I;  4KQV A;  1B63 A;  4USK A;  4KHP I;  4OO1 B;  1FKA E;  2BR2 A;  2PO0 A;  3HJC A;  1IBK I;  2UU9 I;  2NN6 F;  4RPF A;  4DUZ I;  1YH8 A;  2VES A;  3H4L A;  4URL A;  4X66 I;  4LFB I;  4DV3 I;  4DR7 E;  2BA0 D;  1Z5B A;  3H1C A;  4DV0 I;  4IZK A;  3Q6N A;  3JAM C;  3K1J A;  2C37 B;  2CGE A;  5IWA I;  1PIE A;  4JI3 I;  3M85 G;  1I94 I;  4YHH I;  1Z0E A;  4PRX A;  2V34 A;  2Z5B A;  4X65 I;  4IFD D;  4DXL A;  4DUY E;  4LF7 I;  4B3T E;  1MX0 A;  2IER A;  4BA1 A;  5C0X B;  1KTV A;  1Z0W A;  4ISA A;  1Z5A A;  1UDN A;  2CG9 A;  4FW3 A;  4AQY I;  4XTJ A;  4B3M I;  4OO1 E;  2V2Z A;  3M6A A;  5EKW A;  2UXD E;  4DV6 I;  3ZM7 A;  5DNL A;  1N32 I;  4BA2 B;  1BKN A;  1H7U A;  4B3R E;  1N36 I;  4PU9 A;  5LL6 R;  2F4V I;  3B4T A;  1FJG I;  4DV7 E;  4FW9 A;  3V2U C;  2PO2 A;  2JE6 B;  1H72 C;  4NXM E;  3JAM Q;  1WUU A;  2DEJ A;  1Y4U A;  3PYD A;  5JEA B;  1I94 E;  4LCH A;  3KRN A;  5IWA E;  1N0V C;  3GON A;  1HNW E;  3B8H A;  1D6T A;  2J7K A;  3QT7 A;  4JV5 E;  3PYE A;  4R1F A;  1YHC A;  4Z7C A;  4DV3 E;  1A6F A;  5K36 B;  1H74 A;  2VQF E;  1XNR E;  2V2Q A;  2WP8 B;  4HAC A;  2PO1 A;  2UUC E;  3CDI A;  2X7I A;  5DRO A;  2EFG A;  5C0X E;  3CDJ A;  4LFC I;  1Z0B A;  1E3P A;  4LF4 I;  4X66 E;  3GCM A;  2VQE I;  2A2D A;  1U2R A;  2UXC E;  1Y5Y A;  2ZM6 E;  4DR7 I;  4NBQ A;  3LPS A;  2UUA I;  1OJ4 A;  3M7N D;  3HUL A;  2Z5C A;  4YHH E;  3M7N G;  4IZJ D;  4DPY A;  4DV2 E;  4LFA I;  1XNR I;  3DD6 A;  1N32 E;  4JV5 I;  1IBL I;  5EL9 A;  3J7A M;  1OYS A;  2E5L E;  3ZZ0 A;  3M85 D;  2VF3 A;  3Q1Q A;  3OTO E;  3GLL A;  1KVK A;  3WU4 A;  3OTO I;  4DR3 E;  4OO1 A;  4DV6 E;  4AIM A;  4MYU A;  2PNM A;  1PVG A;  5C0X D;  5ELW A;  4LF5 I;  1UDQ A;  4LCG A;  2Z5C B;  4YY3 E;  1XNQ I;  3PS3 A;  1Z0V A;  2BA0 G;  1H73 A;  3CWV A;  1ZXM A;  4DV7 I;  1XMQ I;  1S4E A;  2NN6 B;  2C38 A;  4MU1 A;  1N34 E;  1IBM I;  4LFA E;  5GMD A;  2ZM6 I;  2UUB E;  4FW6 A;  4M1K A;  1S16 A;  2HHH I;  4OX9 I;  4DR5 E;  1USU A;  3J81 Q;  4P52 A;  1Z0C A;  3PYG A;  4FWG A;  2JEB B;  4MU3 A;  2JEA A;  2UUC I;  2HK2 A;  2O1V A;  5JEA D;  2PO0 B;  2BR2 B;  1P42 A;  2C38 B;  4DR4 E;  4MU0 A;  1N0U A;  1FJG E;  2UXB E;  5FLX C;  5FLX Q;  3F0N A;  2BV3 A;  2UXC I;  1MU5 A;  1VI7 A;  1J5E E;  2O1T A;  5DNX A;  1KIJ A;  4K0K I;  4DV0 E;  4LCF A;  3PYF A;  5L3J A;  1RHY A;  4OO1 D;  4USM A;  3WU6 A;  1EI1 A;  4GQU A;  4LF9 E;  4JI5 I;  4MQY A;  2E5L I;  4X62 E;  1RRE A;  5GME A;  2VQF I;  4AID A;  4DPX A;  3L7Z B;  4IZJ A;  2C39 B;  5A2Q C;  4DPT A;  1H7S A;  2NN6 C;  2DEI A;  2OI2 A;  2UXD I;  1FWL A;  4HYM A;  3WU3 A;  2UXB I;  3J80 Q;  2HK3 A;  4DR4 I;  4LFC E;  1NHH A;  3J7A G;  3QT6 A;  4DV1 I;  4GKK E;  2AE8 A;  4IFD C;  4IFD A;  5K36 F;  3J81 C;  1DAR A;  1OYR A;  4DUZ E;  4B3S I;  2WNR A;  4DR1 E;  3B78 A;  4BA2 A;  4WUB A;  4JYA E;  4JI2 E;  2Q2E B;  1UEK A;  4DV5 E;  2Z5E A;  4DR2 I;  2JE6 A;  2NN6 D;  4X64 I;  2BM0 A;  4GKK I;  3QT8 A;  3ZKB A;  2XEX A;  5IT9 C;  5JEA C;  3D4J A;  4EMD A;  2PNZ A;  5JEA A;  2A2C A;  1KKH A;  1IBK E;  1MG7 A;  4OZE A;  2WNR B;  3P06 A;  3J80 C;  2BA1 D;  2O1W A;  2F4V E;  1NZ0 A;  4JI1 I;  1IBM E;  1ELO A;  4JI1 E;  2V8P A;  4LF6 E;  3T1Y I;  4MU4 A;  1R6L A;  2ZIT A;  1ZM2 A;  1Z59 A;  4IFD F;  5K36 A;  4X64 E;  1ZM9 A;  1NHI A;  5A2Q Q;  3ZZU A;  1HNW I;  3T1Y E;  4LF4 E;  2WP8 A;  4B3M E;  4KHP E;  4JI2 I;  1HNX E;  5C0X C;  4JYA I;  4FW4 A; 
#chains in the Genus database with same CATH homology
 4J3D A;  4U3B A;  4MDT A;  3UHM A;  3NZK A;  3P3G A;  2O3Z A;  3PS2 A;  3PS1 A;  1XXE A;  2IER A;  4FW4 A;  5DRP A;  1YH8 A;  2VES A;  4FW6 A;  5DRO A;  2JT2 A;  2J65 A;  4ISA A;  4LCF A;  3U1Y A;  4LCH A;  4OKG A;  4FW3 A;  2IES A;  2GO3 A;  3P3C A;  4U3D A;  4FW7 A;  4LCG A;  4IS9 A;  2GO4 A;  3PS3 A;  5DRQ A;  3P76 A;  5DRR A;  1YHC A;  3P3E A;  4MQY A;  4OZE A;  1P42 A;  4FW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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