4LCHA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-051 complex
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
296
structure length
296
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/antibiotic
total genus 94
structure length 296
sequence length 296
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4lchA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4lchA02
3P3CA 4U3BA 4FW3A 5DROA 4MQYA 3P76A 4OKGA 4U3DA 2O3ZA 5DRRA 4LCFA 1YHCA 4FW5A 5DRPA 4IS9A 4FW7A 4MDTA 1P42A 4LCGA 3NZKA 3UHMA 2GO4A 2VESA 3U1YA 5DRQA 1XXEA 4FW4A 4FW6A 3PS1A 2J65A 4LCHA 3P3EA 4J3DA 2GO3A 3P3GA 2IESA 3PS2A 1YH8A 2JT2A 4ISAA 3PS3A 2IERA 4OZEA
chains in the Genus database with same CATH superfamily
4DUZE 2JE6A 4MYTA 5DROA 4DV3E 5IT9Q 1UDNA 3GLLA 3QT5A 4DR4E 2PO2B 1UEKA 4GQUA 4JI6E 1HNWI 4DPWA 2LJPA 4DV2I 1IBMI 4LFBI 3NZKA 1VI7A 4K0KE 2UXDE 1XHKA 4YHHI 4DV5E 4JYAI 2WP8A 1UDQA 2Z5CB 3WU3A 3WU4A 1N36I 1J5EE 3ZM7A 4DV0I 3J81C 4DR7E 2WNRA 2C37B 4X64I 1K47A 1I94I 4JI4I 1EI1A 1FJGI 2O1UA 4IFDE 3Q6NA 1USUA 5IWAI 5LMUI 4DV4E 2BA1D 1ELOA 5C0XC 4IS9A 4LF9I 2HKEA 5LMNE 4FWGA 4IZJA 5K36B 2PO0A 3U1YA 3JAMC 4OX9E 1XMQE 2PNZA 4FW4A 4YY3I 1Z0TA 4IZKB 4JV5E 4X66I 3Q1QA 4JG4A 4DV6E 4ISAA 1OYSA 2JEBB 3H1CA 4DPXA 4LPFA 2UUAI 1IBKE 3PYGA 2Z5BA 2IOPA 5FLXC 1IBLE 4LF4I 2R3VA 4NBQA 4DV1I 4OO1B 2PO2A 3QT7A 4MU4A 4JI3I 4JI7E 3V5RA 4DR2E 4GKJE 2VQEI 2Z5CA 4DU8A 2VQFE 5IT9C 1D6TA 3QT6A 2NN6C 3K1JA 3ZZUA 4JI8I 2ZBKB 2EFGA 2C37A 4EMDA 2ZM6E 4DPTA 3WU5A 4BA2B 4KHPE 3GCMA 2BR2B 3J81Q 1XMOI 4LF7E 4B3TE 4JI1I 2O1WA 3PYEA 3M85G 1Z0BA 4LF8E 1KKHA 4JI2E 3ZKDA 5K36A 1RREA 4ZVIA 4WUDA 1OYPA 2PO1B 2F4VI 2GO3A 3OTOI 3P3GA 4IZKA 2J7KA 1BKNA 3U1KA 2BM0A 4NXNE 3CWVA 1HNXE 1Z5CA 4MU3A 4U3DA 2Z5EA 2O3ZA 1HNZI 4LF6E 4MYUA 5DRPA 5FWKA 1H72C 2V34A 3KRNA 4OO1A 5BR8E 3DD6A 4LFCI 4FN5A 2PO0B 1B63A 5JEAD 4DUZI 2NN6E 2PNZB 3GONA 4DV3I 1U2RA 2O1VA 4DR4I 3T1YE 1E3HA 4DPUA 2UUCE 4JI6I 1XNQI 2WW4A 4K0KI 1XNRE 4BA2A 1QZRA 1J5EI 2BR2A 1Z0VA 4DR7I 2GQ0A 2BA1G 1H74A 2HKJA 4AQYI 5DRQA 1N0VC 2F1DA 2PO1A 1Y60A 4DV4I 1S16A 4URLA 4QNJA 4DUYI 1WUUA 3J80C 3B82A 4U3BA 1N32I 2BM1A 4DR3E 4OX9I 1XMQI 2PNMA 1DARA 1HK7A 1YHCA 2CZ9A 3B78A 4PU9A 3ZZTA 1P42A 4LCGA 4DV7E 5A2QC 5K36F 1Y5YA 4DV6I 4KQVA 2UXCE 1ZM2A 2HHHE 1B62A 2VF3A 1N0UA 1IBKI 1MG7A 4DV2E 2UUBE 3J7AG 1FI4A 1KVKA 2E5LE 4AM3A 3LNUA 4DR6E 4IFDD 4YHHE 3B8HA 4JYAE 3HJCA 4Z7CA 2CG9A 4JI5E 1H7SA 3P76A 4B3SE 5K36C 1Z0GA 3T1HE 4UTGA 4OO1F 5JEAF 3P06A 2C39B 2VQFI 4X64E 3H4LA 4HXZA 5JEAB 3CDJA 5IWAE 2R42A 2HK2A 2ZM6I 4KHPI 1ZM9A 4FW9A 4B3MI 4B3TI 1NZ0A 4LF5E 2V2QA 1NHIA 4X62I 4OO1C 4DR1I 4LF8I 3P3CA 1Z0WA 4MQYA 1ZM3A 5DRRA 1HR0E 2UU9E 1ZM4A 2BV3A 1KIJA 1N33I 2AJ4A 3B4TA 3J80Q 4NXNI 4LF4E 4R1FA 4B3RI 5C0XA 2C38B 1HNXI 4DV1E 4XTJA 1Y4SA 4JI3E 5A2QQ 4LF6I 1S4EA 2A2DA 5C0XD 2JEAA 1KTVA 1Z0CA 1N34E 5K36E 1NHJA 5LL6R 3Q6MA 3J7AM 2OI2A 2NPFA 1UDOA 2VQEE 1FWKA 1EA6A 4I3HA 4JI8E 2C39A 3F0NA 4DPYA 2UUCI 5JEAA 1R6LA 3PYDA 4JI0I 2HFUA 2V8PA 1ZXNA 1PIEA 4GKKI 4IFDB 1MX0A 4FWHA 1XNRI 1FWLA 4LCHA 4JI1E 4OO1E 1Z5BA 2O1TA 3PS2A 5GMEA 4OZEA 4HYMA 4DU7A 4DR5E 3V2UC 3OTOE 2UXDI 4DV5I 2AE8A 3QT8A 4WUCA 2UXBE 2BA0D 2NN6D 3GMEA 1RR9A 4LFAE 2E1RA 1HNZE 1H73A 3M7ND 4RPFA 2C38A 4FW6A 4DR3I 1Z59A 1Z5AA 4QNKA 1Y6ZA 2IESA 1PVGA 4X65E 2IERA 5LMNI 2UXCI 2HHHI 1OYRA 5DNXA 1XNQE 3PRYA 4UT4A 2UUBI 2E5LI 4NXME 4DR6I 4JV5I 3UHMA 5C0XF 4BA1B 5C0XB 3LPSA 1USVA 4JI5I 4IFDA 2J65A 4B3SI 4USKA 1IBLI 3P3EA 3T1HI 1IBME 1HNWE 2ZITA 3ZKBA 4LFBE 1R6MA 2JEAB 1YH8A 3HULA 4P52A 1FKAE 3PS3A 4AQYE 2DEIA 1OJ4A 4JI7I 3CDIA 4DR2I 2X7IA 1N36E 4GKJI 4LCFA 4DV0E 4ED4A 2X36A 4DUYE 4MDTA 1VISA 1I94E 4P7AA 4JI4E 4LF5I 3D4JA 1N32E 2CGEA 3M6AA 4AIDA 1FJGE 5LMUE 4IZJD 3PS1A 1ZXMA 3LTOA 1HR0I 2UU9I 5ELWA 4LF9E 2IOQA 4LF7I 1E3PA 4WUBA 1UDSA 1NHHA 5JEAC 2NN6F 1RHYA 2PNLA 4JI2I 2NN6B 2V2VA 4YY3E 4X66E 4MU0A 5DNLA 4PRVA 2UUAE 1N34I 2GO4A 2VESA 4BA1A 2XEXA 2A2CA 4M1KA 2Q2EB 3L7ZB 2DEJA 4HACB 1Z0EA 4USMA 4PRXA 2JE6B 5C0XE 4LOMA 3HKMA 5BR8I 1A6FA 4FW3A 1FNMA 4OKGA 1H7UA 3K17A 4B3ME 4FW5A 4X62E 2CVEA 3PYFA 5L3JA 4DR1E 3T1YI 4FWDA 2HK3A 4MU1A 4IFDF 2WP8B 2BA0G 1XMOE 4DR5I 5K36D 1N33E 2WNRB 4J3DA 5JEAE 3M7NG 2JT2A 3K85A 4B3RE 4AIMA 2UXBI 2JEBA 3JAMQ 4LFAI 5EL9A 2V2ZA 1PKPA 2F4VE 5EKWA 2NN6A 3M85D 4FW7A 4DXLA 4IFDC 4HY1A 4X65I 4IZJB 1MU5A 5FLXQ 4OO1D 3ZZ0A 1Y4UA 3WU6A 1XXEA 2HFSA 3L7ZA 5GMDA 4JI0E 4HACA 4LFCE 4NXMI 4DV7I 4N3OA 4GKKE 2GS8A 4Z7YA 2Z5BB
chains in the Genus database with same CATH topology
3P3CA 4U3BA 4FW3A 5DROA 4MQYA 3P76A 4OKGA 4U3DA 2O3ZA 5DRRA 4LCFA 1YHCA 4FW5A 5DRPA 4IS9A 4FW7A 4MDTA 1P42A 4LCGA 3NZKA 3UHMA 2GO4A 2VESA 3U1YA 5DRQA 1XXEA 4FW4A 4FW6A 3PS1A 2J65A 4LCHA 3P3EA 4J3DA 2GO3A 3P3GA 2IESA 3PS2A 1YH8A 2JT2A 4ISAA 3PS3A 2IERA 4OZEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P3C A;  4U3B A;  4FW3 A;  5DRO A;  4MQY A;  3P76 A;  4OKG A;  4U3D A;  2O3Z A;  5DRR A;  4LCF A;  1YHC A;  4FW5 A;  5DRP A;  4IS9 A;  4FW7 A;  4MDT A;  1P42 A;  4LCG A;  3NZK A;  3UHM A;  2GO4 A;  2VES A;  3U1Y A;  5DRQ A;  1XXE A;  4FW4 A;  4FW6 A;  3PS1 A;  2J65 A;  4LCH A;  3P3E A;  4J3D A;  2GO3 A;  3P3G A;  2IES A;  3PS2 A;  1YH8 A;  2JT2 A;  4ISA A;  3PS3 A;  2IER A;  4OZE A; 
#chains in the Genus database with same CATH topology
 4DUZ E;  2JE6 A;  4MYT A;  5DRO A;  4DV3 E;  5IT9 Q;  1UDN A;  3GLL A;  3QT5 A;  4DR4 E;  2PO2 B;  1UEK A;  4GQU A;  4JI6 E;  1HNW I;  4DPW A;  2LJP A;  4DV2 I;  1IBM I;  4LFB I;  3NZK A;  1VI7 A;  4K0K E;  2UXD E;  1XHK A;  4YHH I;  4DV5 E;  4JYA I;  2WP8 A;  1UDQ A;  2Z5C B;  3WU3 A;  3WU4 A;  1N36 I;  1J5E E;  3ZM7 A;  4DV0 I;  3J81 C;  4DR7 E;  2WNR A;  2C37 B;  4X64 I;  1K47 A;  1I94 I;  4JI4 I;  1EI1 A;  1FJG I;  2O1U A;  4IFD E;  3Q6N A;  1USU A;  5IWA I;  5LMU I;  4DV4 E;  2BA1 D;  1ELO A;  5C0X C;  4IS9 A;  4LF9 I;  2HKE A;  5LMN E;  4FWG A;  4IZJ A;  5K36 B;  2PO0 A;  3U1Y A;  3JAM C;  4OX9 E;  1XMQ E;  2PNZ A;  4FW4 A;  4YY3 I;  1Z0T A;  4IZK B;  4JV5 E;  4X66 I;  3Q1Q A;  4JG4 A;  4DV6 E;  4ISA A;  1OYS A;  2JEB B;  3H1C A;  4DPX A;  4LPF A;  2UUA I;  1IBK E;  3PYG A;  2Z5B A;  2IOP A;  5FLX C;  1IBL E;  4LF4 I;  2R3V A;  4NBQ A;  4DV1 I;  4OO1 B;  2PO2 A;  3QT7 A;  4MU4 A;  4JI3 I;  4JI7 E;  3V5R A;  4DR2 E;  4GKJ E;  2VQE I;  2Z5C A;  4DU8 A;  2VQF E;  5IT9 C;  1D6T A;  3QT6 A;  2NN6 C;  3K1J A;  3ZZU A;  4JI8 I;  2ZBK B;  2EFG A;  2C37 A;  4EMD A;  2ZM6 E;  4DPT A;  3WU5 A;  4BA2 B;  4KHP E;  3GCM A;  2BR2 B;  3J81 Q;  1XMO I;  4LF7 E;  4B3T E;  4JI1 I;  2O1W A;  3PYE A;  3M85 G;  1Z0B A;  4LF8 E;  1KKH A;  4JI2 E;  3ZKD A;  5K36 A;  1RRE A;  4ZVI A;  4WUD A;  1OYP A;  2PO1 B;  2F4V I;  2GO3 A;  3OTO I;  3P3G A;  4IZK A;  2J7K A;  1BKN A;  3U1K A;  2BM0 A;  4NXN E;  3CWV A;  1HNX E;  1Z5C A;  4MU3 A;  4U3D A;  2Z5E A;  2O3Z A;  1HNZ I;  4LF6 E;  4MYU A;  5DRP A;  5FWK A;  1H72 C;  2V34 A;  3KRN A;  4OO1 A;  5BR8 E;  3DD6 A;  4LFC I;  4FN5 A;  2PO0 B;  1B63 A;  5JEA D;  4DUZ I;  2NN6 E;  2PNZ B;  3GON A;  4DV3 I;  1U2R A;  2O1V A;  4DR4 I;  3T1Y E;  1E3H A;  4DPU A;  2UUC E;  4JI6 I;  1XNQ I;  2WW4 A;  4K0K I;  1XNR E;  4BA2 A;  1QZR A;  1J5E I;  2BR2 A;  1Z0V A;  4DR7 I;  2GQ0 A;  2BA1 G;  1H74 A;  2HKJ A;  4AQY I;  5DRQ A;  1N0V C;  2F1D A;  2PO1 A;  1Y60 A;  4DV4 I;  1S16 A;  4URL A;  4QNJ A;  4DUY I;  1WUU A;  3J80 C;  3B82 A;  4U3B A;  1N32 I;  2BM1 A;  4DR3 E;  4OX9 I;  1XMQ I;  2PNM A;  1DAR A;  1HK7 A;  1YHC A;  2CZ9 A;  3B78 A;  4PU9 A;  3ZZT A;  1P42 A;  4LCG A;  4DV7 E;  5A2Q C;  5K36 F;  1Y5Y A;  4DV6 I;  4KQV A;  2UXC E;  1ZM2 A;  2HHH E;  1B62 A;  2VF3 A;  1N0U A;  1IBK I;  1MG7 A;  4DV2 E;  2UUB E;  3J7A G;  1FI4 A;  1KVK A;  2E5L E;  4AM3 A;  3LNU A;  4DR6 E;  4IFD D;  4YHH E;  3B8H A;  4JYA E;  3HJC A;  4Z7C A;  2CG9 A;  4JI5 E;  1H7S A;  3P76 A;  4B3S E;  5K36 C;  1Z0G A;  3T1H E;  4UTG A;  4OO1 F;  5JEA F;  3P06 A;  2C39 B;  2VQF I;  4X64 E;  3H4L A;  4HXZ A;  5JEA B;  3CDJ A;  5IWA E;  2R42 A;  2HK2 A;  2ZM6 I;  4KHP I;  1ZM9 A;  4FW9 A;  4B3M I;  4B3T I;  1NZ0 A;  4LF5 E;  2V2Q A;  1NHI A;  4X62 I;  4OO1 C;  4DR1 I;  4LF8 I;  3P3C A;  1Z0W A;  4MQY A;  1ZM3 A;  5DRR A;  1HR0 E;  2UU9 E;  1ZM4 A;  2BV3 A;  1KIJ A;  1N33 I;  2AJ4 A;  3B4T A;  3J80 Q;  4NXN I;  4LF4 E;  4R1F A;  4B3R I;  5C0X A;  2C38 B;  1HNX I;  4DV1 E;  4XTJ A;  1Y4S A;  4JI3 E;  5A2Q Q;  4LF6 I;  1S4E A;  2A2D A;  5C0X D;  2JEA A;  1KTV A;  1Z0C A;  1N34 E;  5K36 E;  1NHJ A;  5LL6 R;  3Q6M A;  3J7A M;  2OI2 A;  2NPF A;  1UDO A;  2VQE E;  1FWK A;  1EA6 A;  4I3H A;  4JI8 E;  2C39 A;  3F0N A;  4DPY A;  2UUC I;  5JEA A;  1R6L A;  3PYD A;  4JI0 I;  2HFU A;  2V8P A;  1ZXN A;  1PIE A;  4GKK I;  4IFD B;  1MX0 A;  4FWH A;  1XNR I;  1FWL A;  4LCH A;  4JI1 E;  4OO1 E;  1Z5B A;  2O1T A;  3PS2 A;  5GME A;  4OZE A;  4HYM A;  4DU7 A;  4DR5 E;  3V2U C;  3OTO E;  2UXD I;  4DV5 I;  2AE8 A;  3QT8 A;  4WUC A;  2UXB E;  2BA0 D;  2NN6 D;  3GME A;  1RR9 A;  4LFA E;  2E1R A;  1HNZ E;  1H73 A;  3M7N D;  4RPF A;  2C38 A;  4FW6 A;  4DR3 I;  1Z59 A;  1Z5A A;  4QNK A;  1Y6Z A;  2IES A;  1PVG A;  4X65 E;  2IER A;  5LMN I;  2UXC I;  2HHH I;  1OYR A;  5DNX A;  1XNQ E;  3PRY A;  4UT4 A;  2UUB I;  2E5L I;  4NXM E;  4DR6 I;  4JV5 I;  3UHM A;  5C0X F;  4BA1 B;  5C0X B;  3LPS A;  1USV A;  4JI5 I;  4IFD A;  2J65 A;  4B3S I;  4USK A;  1IBL I;  3P3E A;  3T1H I;  1IBM E;  1HNW E;  2ZIT A;  3ZKB A;  4LFB E;  1R6M A;  2JEA B;  1YH8 A;  3HUL A;  4P52 A;  1FKA E;  3PS3 A;  4AQY E;  2DEI A;  1OJ4 A;  4JI7 I;  3CDI A;  4DR2 I;  2X7I A;  1N36 E;  4GKJ I;  4LCF A;  4DV0 E;  4ED4 A;  2X36 A;  4DUY E;  4MDT A;  1VIS A;  1I94 E;  4P7A A;  4JI4 E;  4LF5 I;  3D4J A;  1N32 E;  2CGE A;  3M6A A;  4AID A;  1FJG E;  5LMU E;  4IZJ D;  3PS1 A;  1ZXM A;  3LTO A;  1HR0 I;  2UU9 I;  5ELW A;  4LF9 E;  2IOQ A;  4LF7 I;  1E3P A;  4WUB A;  1UDS A;  1NHH A;  5JEA C;  2NN6 F;  1RHY A;  2PNL A;  4JI2 I;  2NN6 B;  2V2V A;  4YY3 E;  4X66 E;  4MU0 A;  5DNL A;  4PRV A;  2UUA E;  1N34 I;  2GO4 A;  2VES A;  4BA1 A;  2XEX A;  2A2C A;  4M1K A;  2Q2E B;  3L7Z B;  2DEJ A;  4HAC B;  1Z0E A;  4USM A;  4PRX A;  2JE6 B;  5C0X E;  4LOM A;  3HKM A;  5BR8 I;  1A6F A;  4FW3 A;  1FNM A;  4OKG A;  1H7U A;  3K17 A;  4B3M E;  4FW5 A;  4X62 E;  2CVE A;  3PYF A;  5L3J A;  4DR1 E;  3T1Y I;  4FWD A;  2HK3 A;  4MU1 A;  4IFD F;  2WP8 B;  2BA0 G;  1XMO E;  4DR5 I;  5K36 D;  1N33 E;  2WNR B;  4J3D A;  5JEA E;  3M7N G;  2JT2 A;  3K85 A;  4B3R E;  4AIM A;  2UXB I;  2JEB A;  3JAM Q;  4LFA I;  5EL9 A;  2V2Z A;  1PKP A;  2F4V E;  5EKW A;  2NN6 A;  3M85 D;  4FW7 A;  4DXL A;  4IFD C;  4HY1 A;  4X65 I;  4IZJ B;  1MU5 A;  5FLX Q;  4OO1 D;  3ZZ0 A;  1Y4U A;  3WU6 A;  1XXE A;  2HFS A;  3L7Z A;  5GMD A;  4JI0 E;  4HAC A;  4LFC E;  4NXM I;  4DV7 I;  4N3O A;  4GKK E;  2GS8 A;  4Z7Y A;  2Z5B B; 
#chains in the Genus database with same CATH homology
 3P3C A;  4U3B A;  4FW3 A;  5DRO A;  4MQY A;  3P76 A;  4OKG A;  4U3D A;  2O3Z A;  5DRR A;  4LCF A;  1YHC A;  4FW5 A;  5DRP A;  4IS9 A;  4FW7 A;  4MDT A;  1P42 A;  4LCG A;  3NZK A;  3UHM A;  2GO4 A;  2VES A;  3U1Y A;  5DRQ A;  1XXE A;  4FW4 A;  4FW6 A;  3PS1 A;  2J65 A;  4LCH A;  3P3E A;  4J3D A;  2GO3 A;  3P3G A;  2IES A;  3PS2 A;  1YH8 A;  2JT2 A;  4ISA A;  3PS3 A;  2IER A;  4OZE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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