4LCHA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-051 complex
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
296
structure length
296
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/antibiotic
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 94
structure length 296
sequence length 296
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4lchA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4lchA02
2J65A 4MDTA 3P3EA 4LCGA 4FW5A 1XXEA 4MQYA 2IERA 4OKGA 3NZKA 2GO4A 3P76A 3U1YA 4FW3A 4FW4A 4U3DA 4IS9A 4ISAA 3PS1A 2GO3A 2IESA 2O3ZA 4LCHA 5DRQA 1YHCA 5DROA 5DRRA 3PS3A 3P3GA 3PS2A 1P42A 4FW6A 4FW7A 3UHMA 2VESA 1YH8A 4LCFA 3P3CA 2JT2A 4J3DA 5DRPA 4U3BA 4OZEA
chains in the Genus database with same CATH superfamily
4Z7CA 5FLXC 5LMNE 4DV1E 3ZM7A 2E5LE 4DV0I 2UUCI 2C38B 4JI0I 1NHHA 1HNZI 4JI2I 3WU4A 1DARA 5A2QC 4LF8I 3PYGA 1USUA 3KRNA 4LCHA 1N33I 5C0XB 2ZM6I 2BM0A 5DRRA 1ELOA 1S4EA 2PNMA 2UXCE 2NN6A 4IZJA 4QNJA 1HR0I 4IZKB 4LCFA 3P3CA 4JI5E 4OX9E 2O1VA 4U3BA 4DV4E 4DPYA 4NXNE 5K36B 1RREA 3PYDA 3M7ND 2C39A 3B4TA 4JV5I 4DV6E 3T1YI 4DV7I 1KKHA 4DXLA 1UDOA 4MU4A 2BM1A 3F0NA 1FJGI 3QT6A 5BR8E 2C37B 2PO0B 4FWHA 1B62A 2EFGA 3ZKBA 2F1DA 4B3SE 5K36E 2WW4A 4X62E 2ZBKB 1P42A 1XNQE 1Z0CA 2VQFE 4B3RE 2BA0D 3WU6A 5JEAD 5JEAA 4DU8A 5K36D 5GMEA 4UT4A 1USVA 1HNXI 4LF9I 1ZXMA 1Z5BA 1Z0BA 2BV3A 3H4LA 2V2ZA 2Z5CA 1N32E 3HULA 4IFDA 1A6FA 4FW4A 1N36E 4JI1E 2JEBA 2WNRB 5IT9C 2Z5BA 4R1FA 4JI8E 2PO1A 1OYPA 2DEIA 4HYMA 2E5LI 1HNWI 4OO1F 4DV5I 1FKAE 3Q6NA 4LF4I 4MDTA 4BA1B 4LF7E 4FW5A 1Y6ZA 2BA1G 4B3TE 1XNRI 4JI4E 2HHHE 1Y4UA 1MX0A 4AQYI 2J7KA 2HFSA 1H73A 1UDQA 2UUAE 2UUBE 1Z59A 4DUYE 1RR9A 3PS2A 2IOPA 2ZITA 4LF5E 4P7AA 1UDNA 1UEKA 4DV6I 3T1YE 4OO1B 4X66I 4IZJD 4KHPE 1ZM4A 1IBLE 4HACB 3ZZ0A 3CWVA 5JEAF 5BR8I 4X65E 3Q1QA 4JYAE 1Z0WA 2NPFA 4NXMI 2Z5CB 4FW3A 2V8PA 4DR5E 4DPXA 4X62I 2DEJA 2VQFI 3K17A 3JAMC 2A2DA 1YHCA 4EMDA 4XTJA 4M1KA 4DR2I 1D6TA 4GQUA 4IFDC 2JEAA 4FW9A 2JE6B 2UU9E 5K36C 1N36I 4BA1A 2UXBE 4DR1I 1VI7A 3J80C 5IWAE 1QZRA 2JEAB 2C39B 1XMQI 3PS1A 1R6LA 3J81Q 3GLLA 4JG4A 1HK7A 3PRYA 1XMOI 4JI6E 1NZ0A 2GQ0A 2CGEA 2LJPA 4YHHE 3PYEA 1FWKA 4DUZE 4OO1C 3J80Q 4JI0E 4DR7I 1Z0GA 4IZJB 2UXDE 5C0XE 2F4VE 4LF6I 2HKJA 5ELWA 4PRVA 4WUBA 1KIJA 1J5EE 2PNLA 1N34I 1R6MA 5JEAB 3J7AM 1H74A 1RHYA 1N0UA 4DPTA 4DV1I 4IFDB 4LFCI 4RPFA 1N0VC 4MU1A 3PS3A 1MG7A 1IBKE 4DR4E 1IBLI 4FW7A 4DPUA 4FWDA 4DV0E 4GKJE 3K1JA 3JAMQ 4DR5I 1PKPA 4WUDA 2NN6E 4OX9I 4DV3E 4DV2E 1N33E 1VISA 1IBME 4UTGA 4DV4I 4JI3E 3U1YA 2PO2A 5L3JA 2O1UA 4U3DA 4NBQA 4ISAA 2CVEA 2PNZA 4IZKA 3PYFA 5LMUI 4MYUA 1FI4A 1HNXE 2V2VA 5K36A 3GCMA 4DR1E 4AM3A 5DRPA 5IWAI 2HK3A 4LPFA 2NN6D 1N32I 4B3SI 4IFDF 2J65A 1UDSA 1Y4SA 3QT8A 3DD6A 1Z0EA 2HKEA 4OKGA 2GO4A 4IFDE 5JEAE 1E3PA 3P06A 1FNMA 4B3RI 4DUZI 5DRQA 3J7AG 1OYRA 2UXDI 2HFUA 4LFAE 3HKMA 4GKKE 2BA0G 2F4VI 4B3TI 4DR6I 1ZM3A 1I94I 3OTOE 4LFBI 4OO1D 1PVGA 4DR3E 4AQYE 4B3MI 4YY3E 5A2QQ 4P52A 4OO1A 4OO1E 2BR2A 4DU7A 2X7IA 2UUBI 1H7SA 4DR4I 4USMA 3WU3A 4PRXA 2WP8A 5K36F 2IESA 2C38A 2VQEI 1HNZE 4K0KI 4GKJI 4JI7I 2PO0A 3LNUA 2BR2B 3B78A 1EA6A 4WUCA 4JYAI 2ZM6E 2HHHI 1IBMI 4JI3I 4OZEA 4AIMA 4MU0A 2Q2EB 3ZZTA 1Z5AA 1K47A 1U2RA 3T1HI 3CDJA 2BA1D 4LF8E 2JEBB 4X66E 3P76A 5LMNI 4IFDD 4JI5I 2VF3A 4JV5E 2O3ZA 5EKWA 5LL6R 2O1WA 3P3GA 4JI2E 1FJGE 2WNRA 2Z5BB 1YH8A 4I3HA 4MU3A 5DROA 4DV7E 4AIDA 3WU5A 1KTVA 4X64I 4NXME 4DR2E 3L7ZA 4FN5A 1FWLA 4MQYA 1XXEA 4JI6I 4QNKA 2OI2A 4LF9E 2UU9I 2UXBI 2AE8A 1WUUA 3LTOA 2PNZB 2R42A 1KVKA 2V34A 2PO2B 2HK2A 1Z5CA 1OJ4A 3CDIA 3LPSA 4JI8I 5EL9A 1XNQI 5C0XA 3M7NG 1NHIA 3H1CA 2IERA 3D4JA 1HNWE 2VQEE 4DR7E 4LF4E 4K0KE 4JI7E 2NN6B 5C0XC 4DV5E 2O1TA 4DPWA 3HJCA 4JI1I 3T1HE 2UUAI 1IBKI 2A2CA 4LF5I 1N34E 3P3EA 5DNXA 3L7ZB 2X36A 3V5RA 5FWKA 1Z0TA 2C37A 4KHPI 1BKNA 4DUYI 4LF7I 4IS9A 3ZZUA 2PO1B 1XNRE 4JI4I 3QT5A 4DV3I 2NN6C 2UUCE 1H72C 4MYTA 4USKA 1EI1A 2XEXA 4N3OA 2E1RA 4X64E 1ZM2A 4ZVIA 3UHMA 5LMUE 2JT2A 4X65I 4HY1A 2IOQA 4ED4A 4HXZA 4PU9A 4URLA 4DV2I 2UXCI 2NN6F 2Z5EA 1Y60A 3B82A 1HR0E 2AJ4A 2GS8A 3J81C 3M85G 3K85A 1H7UA 5C0XF 2JE6A 1XHKA 4NXNI 1ZXNA 4BA2B 2R3VA 2GO3A 3GMEA 4KQVA 5IT9Q 5DNLA 1E3HA 5FLXQ 1S16A 1Z0VA 4DR6E 5GMDA 5JEAC 4FW6A 1XMQE 3V2UC 2WP8B 2VESA 4BA2A 4FWGA 3M6AA 1ZM9A 3B8HA 1MU5A 2CZ9A 4GKKI 2V2QA 4LCGA 3ZKDA 3M85D 3NZKA 1XMOE 3GONA 4LOMA 4DR3I 1B63A 4YHHI 4B3ME 4LF6E 4LFAI 1PIEA 4YY3I 1Y5YA 3Q6MA 3U1KA 1I94E 5C0XD 3OTOI 2CG9A 3QT7A 4LFBE 4HACA 4LFCE 1NHJA 4J3DA 1OYSA 1J5EI 4Z7YA
chains in the Genus database with same CATH topology
2J65A 4MDTA 3P3EA 4LCGA 4FW5A 1XXEA 4MQYA 2IERA 4OKGA 3NZKA 2GO4A 3P76A 3U1YA 4FW3A 4FW4A 4U3DA 4IS9A 4ISAA 3PS1A 2GO3A 2IESA 2O3ZA 4LCHA 5DRQA 1YHCA 5DROA 5DRRA 3PS3A 3P3GA 3PS2A 1P42A 4FW6A 4FW7A 3UHMA 2VESA 1YH8A 4LCFA 3P3CA 2JT2A 4J3DA 5DRPA 4U3BA 4OZEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J65 A;  4MDT A;  3P3E A;  4LCG A;  4FW5 A;  1XXE A;  4MQY A;  2IER A;  4OKG A;  3NZK A;  2GO4 A;  3P76 A;  3U1Y A;  4FW3 A;  4FW4 A;  4U3D A;  4IS9 A;  4ISA A;  3PS1 A;  2GO3 A;  2IES A;  2O3Z A;  4LCH A;  5DRQ A;  1YHC A;  5DRO A;  5DRR A;  3PS3 A;  3P3G A;  3PS2 A;  1P42 A;  4FW6 A;  4FW7 A;  3UHM A;  2VES A;  1YH8 A;  4LCF A;  3P3C A;  2JT2 A;  4J3D A;  5DRP A;  4U3B A;  4OZE A; 
#chains in the Genus database with same CATH topology
 4Z7C A;  5FLX C;  5LMN E;  4DV1 E;  3ZM7 A;  2E5L E;  4DV0 I;  2UUC I;  2C38 B;  4JI0 I;  1NHH A;  1HNZ I;  4JI2 I;  3WU4 A;  1DAR A;  5A2Q C;  4LF8 I;  3PYG A;  1USU A;  3KRN A;  4LCH A;  1N33 I;  5C0X B;  2ZM6 I;  2BM0 A;  5DRR A;  1ELO A;  1S4E A;  2PNM A;  2UXC E;  2NN6 A;  4IZJ A;  4QNJ A;  1HR0 I;  4IZK B;  4LCF A;  3P3C A;  4JI5 E;  4OX9 E;  2O1V A;  4U3B A;  4DV4 E;  4DPY A;  4NXN E;  5K36 B;  1RRE A;  3PYD A;  3M7N D;  2C39 A;  3B4T A;  4JV5 I;  4DV6 E;  3T1Y I;  4DV7 I;  1KKH A;  4DXL A;  1UDO A;  4MU4 A;  2BM1 A;  3F0N A;  1FJG I;  3QT6 A;  5BR8 E;  2C37 B;  2PO0 B;  4FWH A;  1B62 A;  2EFG A;  3ZKB A;  2F1D A;  4B3S E;  5K36 E;  2WW4 A;  4X62 E;  2ZBK B;  1P42 A;  1XNQ E;  1Z0C A;  2VQF E;  4B3R E;  2BA0 D;  3WU6 A;  5JEA D;  5JEA A;  4DU8 A;  5K36 D;  5GME A;  4UT4 A;  1USV A;  1HNX I;  4LF9 I;  1ZXM A;  1Z5B A;  1Z0B A;  2BV3 A;  3H4L A;  2V2Z A;  2Z5C A;  1N32 E;  3HUL A;  4IFD A;  1A6F A;  4FW4 A;  1N36 E;  4JI1 E;  2JEB A;  2WNR B;  5IT9 C;  2Z5B A;  4R1F A;  4JI8 E;  2PO1 A;  1OYP A;  2DEI A;  4HYM A;  2E5L I;  1HNW I;  4OO1 F;  4DV5 I;  1FKA E;  3Q6N A;  4LF4 I;  4MDT A;  4BA1 B;  4LF7 E;  4FW5 A;  1Y6Z A;  2BA1 G;  4B3T E;  1XNR I;  4JI4 E;  2HHH E;  1Y4U A;  1MX0 A;  4AQY I;  2J7K A;  2HFS A;  1H73 A;  1UDQ A;  2UUA E;  2UUB E;  1Z59 A;  4DUY E;  1RR9 A;  3PS2 A;  2IOP A;  2ZIT A;  4LF5 E;  4P7A A;  1UDN A;  1UEK A;  4DV6 I;  3T1Y E;  4OO1 B;  4X66 I;  4IZJ D;  4KHP E;  1ZM4 A;  1IBL E;  4HAC B;  3ZZ0 A;  3CWV A;  5JEA F;  5BR8 I;  4X65 E;  3Q1Q A;  4JYA E;  1Z0W A;  2NPF A;  4NXM I;  2Z5C B;  4FW3 A;  2V8P A;  4DR5 E;  4DPX A;  4X62 I;  2DEJ A;  2VQF I;  3K17 A;  3JAM C;  2A2D A;  1YHC A;  4EMD A;  4XTJ A;  4M1K A;  4DR2 I;  1D6T A;  4GQU A;  4IFD C;  2JEA A;  4FW9 A;  2JE6 B;  2UU9 E;  5K36 C;  1N36 I;  4BA1 A;  2UXB E;  4DR1 I;  1VI7 A;  3J80 C;  5IWA E;  1QZR A;  2JEA B;  2C39 B;  1XMQ I;  3PS1 A;  1R6L A;  3J81 Q;  3GLL A;  4JG4 A;  1HK7 A;  3PRY A;  1XMO I;  4JI6 E;  1NZ0 A;  2GQ0 A;  2CGE A;  2LJP A;  4YHH E;  3PYE A;  1FWK A;  4DUZ E;  4OO1 C;  3J80 Q;  4JI0 E;  4DR7 I;  1Z0G A;  4IZJ B;  2UXD E;  5C0X E;  2F4V E;  4LF6 I;  2HKJ A;  5ELW A;  4PRV A;  4WUB A;  1KIJ A;  1J5E E;  2PNL A;  1N34 I;  1R6M A;  5JEA B;  3J7A M;  1H74 A;  1RHY A;  1N0U A;  4DPT A;  4DV1 I;  4IFD B;  4LFC I;  4RPF A;  1N0V C;  4MU1 A;  3PS3 A;  1MG7 A;  1IBK E;  4DR4 E;  1IBL I;  4FW7 A;  4DPU A;  4FWD A;  4DV0 E;  4GKJ E;  3K1J A;  3JAM Q;  4DR5 I;  1PKP A;  4WUD A;  2NN6 E;  4OX9 I;  4DV3 E;  4DV2 E;  1N33 E;  1VIS A;  1IBM E;  4UTG A;  4DV4 I;  4JI3 E;  3U1Y A;  2PO2 A;  5L3J A;  2O1U A;  4U3D A;  4NBQ A;  4ISA A;  2CVE A;  2PNZ A;  4IZK A;  3PYF A;  5LMU I;  4MYU A;  1FI4 A;  1HNX E;  2V2V A;  5K36 A;  3GCM A;  4DR1 E;  4AM3 A;  5DRP A;  5IWA I;  2HK3 A;  4LPF A;  2NN6 D;  1N32 I;  4B3S I;  4IFD F;  2J65 A;  1UDS A;  1Y4S A;  3QT8 A;  3DD6 A;  1Z0E A;  2HKE A;  4OKG A;  2GO4 A;  4IFD E;  5JEA E;  1E3P A;  3P06 A;  1FNM A;  4B3R I;  4DUZ I;  5DRQ A;  3J7A G;  1OYR A;  2UXD I;  2HFU A;  4LFA E;  3HKM A;  4GKK E;  2BA0 G;  2F4V I;  4B3T I;  4DR6 I;  1ZM3 A;  1I94 I;  3OTO E;  4LFB I;  4OO1 D;  1PVG A;  4DR3 E;  4AQY E;  4B3M I;  4YY3 E;  5A2Q Q;  4P52 A;  4OO1 A;  4OO1 E;  2BR2 A;  4DU7 A;  2X7I A;  2UUB I;  1H7S A;  4DR4 I;  4USM A;  3WU3 A;  4PRX A;  2WP8 A;  5K36 F;  2IES A;  2C38 A;  2VQE I;  1HNZ E;  4K0K I;  4GKJ I;  4JI7 I;  2PO0 A;  3LNU A;  2BR2 B;  3B78 A;  1EA6 A;  4WUC A;  4JYA I;  2ZM6 E;  2HHH I;  1IBM I;  4JI3 I;  4OZE A;  4AIM A;  4MU0 A;  2Q2E B;  3ZZT A;  1Z5A A;  1K47 A;  1U2R A;  3T1H I;  3CDJ A;  2BA1 D;  4LF8 E;  2JEB B;  4X66 E;  3P76 A;  5LMN I;  4IFD D;  4JI5 I;  2VF3 A;  4JV5 E;  2O3Z A;  5EKW A;  5LL6 R;  2O1W A;  3P3G A;  4JI2 E;  1FJG E;  2WNR A;  2Z5B B;  1YH8 A;  4I3H A;  4MU3 A;  5DRO A;  4DV7 E;  4AID A;  3WU5 A;  1KTV A;  4X64 I;  4NXM E;  4DR2 E;  3L7Z A;  4FN5 A;  1FWL A;  4MQY A;  1XXE A;  4JI6 I;  4QNK A;  2OI2 A;  4LF9 E;  2UU9 I;  2UXB I;  2AE8 A;  1WUU A;  3LTO A;  2PNZ B;  2R42 A;  1KVK A;  2V34 A;  2PO2 B;  2HK2 A;  1Z5C A;  1OJ4 A;  3CDI A;  3LPS A;  4JI8 I;  5EL9 A;  1XNQ I;  5C0X A;  3M7N G;  1NHI A;  3H1C A;  2IER A;  3D4J A;  1HNW E;  2VQE E;  4DR7 E;  4LF4 E;  4K0K E;  4JI7 E;  2NN6 B;  5C0X C;  4DV5 E;  2O1T A;  4DPW A;  3HJC A;  4JI1 I;  3T1H E;  2UUA I;  1IBK I;  2A2C A;  4LF5 I;  1N34 E;  3P3E A;  5DNX A;  3L7Z B;  2X36 A;  3V5R A;  5FWK A;  1Z0T A;  2C37 A;  4KHP I;  1BKN A;  4DUY I;  4LF7 I;  4IS9 A;  3ZZU A;  2PO1 B;  1XNR E;  4JI4 I;  3QT5 A;  4DV3 I;  2NN6 C;  2UUC E;  1H72 C;  4MYT A;  4USK A;  1EI1 A;  2XEX A;  4N3O A;  2E1R A;  4X64 E;  1ZM2 A;  4ZVI A;  3UHM A;  5LMU E;  2JT2 A;  4X65 I;  4HY1 A;  2IOQ A;  4ED4 A;  4HXZ A;  4PU9 A;  4URL A;  4DV2 I;  2UXC I;  2NN6 F;  2Z5E A;  1Y60 A;  3B82 A;  1HR0 E;  2AJ4 A;  2GS8 A;  3J81 C;  3M85 G;  3K85 A;  1H7U A;  5C0X F;  2JE6 A;  1XHK A;  4NXN I;  1ZXN A;  4BA2 B;  2R3V A;  2GO3 A;  3GME A;  4KQV A;  5IT9 Q;  5DNL A;  1E3H A;  5FLX Q;  1S16 A;  1Z0V A;  4DR6 E;  5GMD A;  5JEA C;  4FW6 A;  1XMQ E;  3V2U C;  2WP8 B;  2VES A;  4BA2 A;  4FWG A;  3M6A A;  1ZM9 A;  3B8H A;  1MU5 A;  2CZ9 A;  4GKK I;  2V2Q A;  4LCG A;  3ZKD A;  3M85 D;  3NZK A;  1XMO E;  3GON A;  4LOM A;  4DR3 I;  1B63 A;  4YHH I;  4B3M E;  4LF6 E;  4LFA I;  1PIE A;  4YY3 I;  1Y5Y A;  3Q6M A;  3U1K A;  1I94 E;  5C0X D;  3OTO I;  2CG9 A;  3QT7 A;  4LFB E;  4HAC A;  4LFC E;  1NHJ A;  4J3D A;  1OYS A;  1J5E I;  4Z7Y A; 
#chains in the Genus database with same CATH homology
 2J65 A;  4MDT A;  3P3E A;  4LCG A;  4FW5 A;  1XXE A;  4MQY A;  2IER A;  4OKG A;  3NZK A;  2GO4 A;  3P76 A;  3U1Y A;  4FW3 A;  4FW4 A;  4U3D A;  4IS9 A;  4ISA A;  3PS1 A;  2GO3 A;  2IES A;  2O3Z A;  4LCH A;  5DRQ A;  1YHC A;  5DRO A;  5DRR A;  3PS3 A;  3P3G A;  3PS2 A;  1P42 A;  4FW6 A;  4FW7 A;  3UHM A;  2VES A;  1YH8 A;  4LCF A;  3P3C A;  2JT2 A;  4J3D A;  5DRP A;  4U3B A;  4OZE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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