4LCHA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-051 complex
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
296
structure length
296
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/antibiotic
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
total genus 94
structure length 296
sequence length 296
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2013-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4lchA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4lchA02
2GO3A 4IS9A 4LCGA 3U1YA 3UHMA 2JT2A 2O3ZA 1YHCA 4MDTA 4OKGA 4U3BA 4FW5A 4LCHA 4J3DA 2VESA 3PS3A 4FW4A 2J65A 3P3EA 4U3DA 3P76A 4OZEA 1XXEA 4ISAA 5DRRA 5DRQA 3P3GA 4FW3A 5DROA 4MQYA 4FW7A 3P3CA 5DRPA 2IESA 1P42A 4LCFA 2IERA 3PS2A 3NZKA 2GO4A 1YH8A 3PS1A 4FW6A
chains in the Genus database with same CATH superfamily
3U1YA 1MG7A 3ZKBA 4DR6I 3ZZ0A 4RPFA 4LF9I 2X36A 4X66E 4OO1E 4FW5A 4LFCI 3GONA 4DUZI 3M6AA 5FWKA 4LPFA 3CWVA 5DRRA 3P3GA 4IZJB 4YY3I 4HY1A 4DV0E 5LMUI 4JI8E 5K36F 4DUYE 5BR8E 2NN6B 2PO2A 4FW9A 3JAMC 2ZM6I 1HK7A 2JE6A 3HJCA 4JI5E 5FLXC 2NN6C 4IFDD 4LF6I 4LFAE 1UEKA 1NZ0A 2HKJA 5LMNI 4BA1A 4PU9A 2CZ9A 4LFBI 5IWAE 1Y4SA 4NXME 2PNZA 4JI3I 1Y4UA 3T1HI 2HFSA 4PRXA 2Z5EA 1Z5AA 2R3VA 4DR7E 2VQEI 1P42A 2BV3A 4IFDF 3PYGA 1VI7A 4LF9E 1Z0VA 4XTJA 3H1CA 5DNXA 3PYFA 3GCMA 4LFCE 4R1FA 2JT2A 4DUZE 4OO1D 2BM0A 1Z0BA 5K36C 2PNLA 4YY3E 5LMUE 4B3MI 4JYAI 4K0KI 2C37A 2BM1A 4FWGA 2ZITA 3J80Q 2ZM6E 4FW3A 4JG4A 4JI4E 4JI2E 1XHKA 3PYEA 2WP8B 4LF6E 4DV5I 4JV5I 1Z5BA 5JEAF 1WUUA 3V2UC 3PS1A 5LMNE 4JI0E 2VQFI 4OO1F 4DPWA 2GQ0A 4LFBE 1ZXNA 2UUCI 1FWKA 1YHCA 3F0NA 4JI3E 2UXBI 1K47A 3T1HE 2PNMA 1FKAE 4NBQA 4HYMA 1H73A 4FW4A 3QT8A 2VQEE 2GS8A 4USKA 1N0UA 1FI4A 4X65I 5C0XA 4MYTA 1N33I 4DV6E 1PKPA 2WNRB 1IBMI 2PO1B 2JEBA 1Y60A 4DV2E 2O1VA 2GO3A 4PRVA 3LNUA 4OX9E 4JI5I 5JEAB 4UT4A 5IT9Q 5JEAC 4DV5E 5C0XE 2CGEA 3Q6NA 1U2RA 1ZM9A 4OO1C 1H7SA 3ZZUA 4DR5I 1Z0CA 3GLLA 2PO0A 3L7ZB 4WUDA 1R6LA 2Z5CB 1D6TA 2UUCE 3DD6A 4P52A 1J5EI 2UXBE 4ED4A 2V2QA 3J80C 4DR7I 1FWLA 1ZM3A 2BR2B 2O1WA 3UHMA 1HR0I 2O3ZA 4MU1A 4URLA 5LL6R 3T1YI 2LJPA 4LCHA 2C38A 5EL9A 1FNMA 4KQVA 2HK2A 4X65E 4WUCA 2IOQA 1N33E 2DEJA 2UUBI 4I3HA 1XMQI 2C39B 1UDSA 1IBME 4B3RI 2V2VA 1OYPA 1IBLI 2A2CA 1B63A 1RREA 4DR1I 4DPTA 4JI2I 4JI4I 2IOPA 3Q6MA 1ZXMA 4B3SE 4JI0I 4BA1B 2J7KA 3J7AG 1Z0TA 4DR5E 5C0XD 3ZKDA 4OZEA 2Z5BB 4ISAA 2BA0G 2F1DA 4IZJA 4P7AA 1J5EE 4MQYA 2NN6A 1A6FA 4WUBA 4DPYA 3B8HA 4AQYE 1HR0E 3M7NG 2JEAB 1OJ4A 2V8PA 2F4VE 5IT9C 4MYUA 1YH8A 1FJGI 3T1YE 4MU4A 1N0VC 4HACB 5GMDA 5K36B 4DV6I 1EA6A 1NHIA 5C0XF 1OYSA 2HFUA 2UUBE 4DV2I 4UTGA 2VESA 1XMQE 4B3RE 4DU7A 4OX9I 4N3OA 2NN6E 1NHJA 1USVA 1IBLE 1PVGA 2V2ZA 4M1KA 4USMA 4FW7A 4DR1E 1BKNA 1NHHA 1B62A 2BA1D 4AIDA 1Y6ZA 3LTOA 4DPUA 1USUA 1PIEA 2EFGA 4NXNI 4IFDB 3CDIA 1XNQI 4KHPI 1H74A 2V34A 3P76A 4JI1I 4LF5E 1RHYA 1UDQA 2BA1G 4IFDC 2O1TA 2UXCI 1I94I 4MU3A 4IZKB 2WP8A 3P3CA 1FJGE 3K17A 2R42A 1HNZI 1Y5YA 4BA2B 3M85D 4DXLA 1IBKE 4Z7YA 2AE8A 2E5LI 2HKEA 3HULA 4IZJD 3V5RA 4GKKI 4DU8A 4OO1B 2NN6D 4DR3I 3QT7A 1XMOI 3LPSA 4YHHI 4B3SI 3M85G 3U1KA 4ZVIA 4B3TI 3H4LA 3ZZTA 4NXNE 4LOMA 2PO1A 3B4TA 4FW6A 2AJ4A 2ZBKB 3QT6A 1XNQE 2CVEA 4IS9A 4LCGA 4AQYI 4MDTA 4KHPE 4JI1E 2F4VI 5JEAA 2NN6F 4FWHA 2UXCE 3PS3A 1N36E 1I94E 3P3EA 4LF4I 3HKMA 1QZRA 1HNXI 2HHHI 3QT5A 2CG9A 1XNRI 2O1UA 1HNZE 1OYRA 3L7ZA 5DRPA 2Z5CA 4LF7E 2PO2B 3ZM7A 2JE6B 2NPFA 2BA0D 4DV1E 2E5LE 4LF8E 2BR2A 5JEAE 4GKKE 4OKGA 4JI7I 4DR3E 1XMOE 1Z0EA 3GMEA 3M7ND 3Q1QA 4YHHE 3B78A 1Z59A 4FWDA 4FN5A 4U3DA 5DNLA 2PNZB 4AM3A 5EKWA 2A2DA 4DPXA 4B3TE 2C39A 1S16A 1KTVA 4GQUA 1Z0GA 4LF5I 2DEIA 1MX0A 4LCFA 4DV7I 2UU9I 2IERA 1HNWI 3J81Q 1N34I 3P06A 2GO4A 4DR4E 1ZM4A 1UDOA 4GKJI 4Z7CA 4X62E 4LF4E 1HNXE 2HHHE 3OTOI 1XNRE 1IBKI 2Z5BA 2C37B 1RR9A 1XXEA 2HK3A 4X64I 2UXDI 4DV4I 5A2QC 4DR6E 2JEAA 1KIJA 4JI7E 5JEAD 1MU5A 5L3JA 1EI1A 1KVKA 4HACA 1ELOA 1H72C 5K36A 1Z5CA 3WU6A 2WW4A 1KKHA 4QNKA 2UUAI 4DV3I 1DARA 4QNJA 4AIMA 2XEXA 4JI6I 3B82A 2E1RA 1Z0WA 4DV7E 2UU9E 1N32I 1HNWE 3WU4A 1N34E 1N36I 5C0XB 4GKJE 1H7UA 3KRNA 3NZKA 5K36E 5C0XC 3OTOE 2JEBB 4J3DA 2OI2A 4DR2I 4LF7I 5GMEA 4IFDA 4DV1I 4LF8I 3J81C 3CDJA 2J65A 3JAMQ 4X64E 2UXDE 4X66I 4DV4E 5FLXQ 5DROA 4IZKA 2IESA 2PO0B 3J7AM 3D4JA 3PS2A 4BA2A 4DV0I 5ELWA 4JI8I 2UUAE 2WNRA 4DV3E 1R6MA 4DUYI 5BR8I 1ZM2A 1UDNA 4IFDE 4JYAE 4B3ME 4K0KE 4U3BA 1VISA 3WU5A 4JI6E 1E3PA 4DR4I 4LFAI 2C38B 2Q2EB 1N32E 5A2QQ 4OO1A 4EMDA 4JV5E 4X62I 4HXZA 5DRQA 1E3HA 4MU0A 5IWAI 2VQFE 4NXMI 3K85A 2VF3A 3PYDA 4DR2E 5K36D 2X7IA 3WU3A 1S4EA 3PRYA 3K1JA
chains in the Genus database with same CATH topology
2GO3A 4IS9A 4LCGA 3U1YA 3UHMA 2JT2A 2O3ZA 1YHCA 4MDTA 4OKGA 4U3BA 4FW5A 4LCHA 4J3DA 2VESA 3PS3A 4FW4A 2J65A 3P3EA 4U3DA 3P76A 4OZEA 1XXEA 4ISAA 5DRRA 5DRQA 3P3GA 4FW3A 5DROA 4MQYA 4FW7A 3P3CA 5DRPA 2IESA 1P42A 4LCFA 2IERA 3PS2A 3NZKA 2GO4A 1YH8A 3PS1A 4FW6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GO3 A;  4IS9 A;  4LCG A;  3U1Y A;  3UHM A;  2JT2 A;  2O3Z A;  1YHC A;  4MDT A;  4OKG A;  4U3B A;  4FW5 A;  4LCH A;  4J3D A;  2VES A;  3PS3 A;  4FW4 A;  2J65 A;  3P3E A;  4U3D A;  3P76 A;  4OZE A;  1XXE A;  4ISA A;  5DRR A;  5DRQ A;  3P3G A;  4FW3 A;  5DRO A;  4MQY A;  4FW7 A;  3P3C A;  5DRP A;  2IES A;  1P42 A;  4LCF A;  2IER A;  3PS2 A;  3NZK A;  2GO4 A;  1YH8 A;  3PS1 A;  4FW6 A; 
#chains in the Genus database with same CATH topology
 3U1Y A;  1MG7 A;  3ZKB A;  4DR6 I;  3ZZ0 A;  4RPF A;  4LF9 I;  2X36 A;  4X66 E;  4OO1 E;  4FW5 A;  4LFC I;  3GON A;  4DUZ I;  3M6A A;  5FWK A;  4LPF A;  3CWV A;  5DRR A;  3P3G A;  4IZJ B;  4YY3 I;  4HY1 A;  4DV0 E;  5LMU I;  4JI8 E;  5K36 F;  4DUY E;  5BR8 E;  2NN6 B;  2PO2 A;  4FW9 A;  3JAM C;  2ZM6 I;  1HK7 A;  2JE6 A;  3HJC A;  4JI5 E;  5FLX C;  2NN6 C;  4IFD D;  4LF6 I;  4LFA E;  1UEK A;  1NZ0 A;  2HKJ A;  5LMN I;  4BA1 A;  4PU9 A;  2CZ9 A;  4LFB I;  5IWA E;  1Y4S A;  4NXM E;  2PNZ A;  4JI3 I;  1Y4U A;  3T1H I;  2HFS A;  4PRX A;  2Z5E A;  1Z5A A;  2R3V A;  4DR7 E;  2VQE I;  1P42 A;  2BV3 A;  4IFD F;  3PYG A;  1VI7 A;  4LF9 E;  1Z0V A;  4XTJ A;  3H1C A;  5DNX A;  3PYF A;  3GCM A;  4LFC E;  4R1F A;  2JT2 A;  4DUZ E;  4OO1 D;  2BM0 A;  1Z0B A;  5K36 C;  2PNL A;  4YY3 E;  5LMU E;  4B3M I;  4JYA I;  4K0K I;  2C37 A;  2BM1 A;  4FWG A;  2ZIT A;  3J80 Q;  2ZM6 E;  4FW3 A;  4JG4 A;  4JI4 E;  4JI2 E;  1XHK A;  3PYE A;  2WP8 B;  4LF6 E;  4DV5 I;  4JV5 I;  1Z5B A;  5JEA F;  1WUU A;  3V2U C;  3PS1 A;  5LMN E;  4JI0 E;  2VQF I;  4OO1 F;  4DPW A;  2GQ0 A;  4LFB E;  1ZXN A;  2UUC I;  1FWK A;  1YHC A;  3F0N A;  4JI3 E;  2UXB I;  1K47 A;  3T1H E;  2PNM A;  1FKA E;  4NBQ A;  4HYM A;  1H73 A;  4FW4 A;  3QT8 A;  2VQE E;  2GS8 A;  4USK A;  1N0U A;  1FI4 A;  4X65 I;  5C0X A;  4MYT A;  1N33 I;  4DV6 E;  1PKP A;  2WNR B;  1IBM I;  2PO1 B;  2JEB A;  1Y60 A;  4DV2 E;  2O1V A;  2GO3 A;  4PRV A;  3LNU A;  4OX9 E;  4JI5 I;  5JEA B;  4UT4 A;  5IT9 Q;  5JEA C;  4DV5 E;  5C0X E;  2CGE A;  3Q6N A;  1U2R A;  1ZM9 A;  4OO1 C;  1H7S A;  3ZZU A;  4DR5 I;  1Z0C A;  3GLL A;  2PO0 A;  3L7Z B;  4WUD A;  1R6L A;  2Z5C B;  1D6T A;  2UUC E;  3DD6 A;  4P52 A;  1J5E I;  2UXB E;  4ED4 A;  2V2Q A;  3J80 C;  4DR7 I;  1FWL A;  1ZM3 A;  2BR2 B;  2O1W A;  3UHM A;  1HR0 I;  2O3Z A;  4MU1 A;  4URL A;  5LL6 R;  3T1Y I;  2LJP A;  4LCH A;  2C38 A;  5EL9 A;  1FNM A;  4KQV A;  2HK2 A;  4X65 E;  4WUC A;  2IOQ A;  1N33 E;  2DEJ A;  2UUB I;  4I3H A;  1XMQ I;  2C39 B;  1UDS A;  1IBM E;  4B3R I;  2V2V A;  1OYP A;  1IBL I;  2A2C A;  1B63 A;  1RRE A;  4DR1 I;  4DPT A;  4JI2 I;  4JI4 I;  2IOP A;  3Q6M A;  1ZXM A;  4B3S E;  4JI0 I;  4BA1 B;  2J7K A;  3J7A G;  1Z0T A;  4DR5 E;  5C0X D;  3ZKD A;  4OZE A;  2Z5B B;  4ISA A;  2BA0 G;  2F1D A;  4IZJ A;  4P7A A;  1J5E E;  4MQY A;  2NN6 A;  1A6F A;  4WUB A;  4DPY A;  3B8H A;  4AQY E;  1HR0 E;  3M7N G;  2JEA B;  1OJ4 A;  2V8P A;  2F4V E;  5IT9 C;  4MYU A;  1YH8 A;  1FJG I;  3T1Y E;  4MU4 A;  1N0V C;  4HAC B;  5GMD A;  5K36 B;  4DV6 I;  1EA6 A;  1NHI A;  5C0X F;  1OYS A;  2HFU A;  2UUB E;  4DV2 I;  4UTG A;  2VES A;  1XMQ E;  4B3R E;  4DU7 A;  4OX9 I;  4N3O A;  2NN6 E;  1NHJ A;  1USV A;  1IBL E;  1PVG A;  2V2Z A;  4M1K A;  4USM A;  4FW7 A;  4DR1 E;  1BKN A;  1NHH A;  1B62 A;  2BA1 D;  4AID A;  1Y6Z A;  3LTO A;  4DPU A;  1USU A;  1PIE A;  2EFG A;  4NXN I;  4IFD B;  3CDI A;  1XNQ I;  4KHP I;  1H74 A;  2V34 A;  3P76 A;  4JI1 I;  4LF5 E;  1RHY A;  1UDQ A;  2BA1 G;  4IFD C;  2O1T A;  2UXC I;  1I94 I;  4MU3 A;  4IZK B;  2WP8 A;  3P3C A;  1FJG E;  3K17 A;  2R42 A;  1HNZ I;  1Y5Y A;  4BA2 B;  3M85 D;  4DXL A;  1IBK E;  4Z7Y A;  2AE8 A;  2E5L I;  2HKE A;  3HUL A;  4IZJ D;  3V5R A;  4GKK I;  4DU8 A;  4OO1 B;  2NN6 D;  4DR3 I;  3QT7 A;  1XMO I;  3LPS A;  4YHH I;  4B3S I;  3M85 G;  3U1K A;  4ZVI A;  4B3T I;  3H4L A;  3ZZT A;  4NXN E;  4LOM A;  2PO1 A;  3B4T A;  4FW6 A;  2AJ4 A;  2ZBK B;  3QT6 A;  1XNQ E;  2CVE A;  4IS9 A;  4LCG A;  4AQY I;  4MDT A;  4KHP E;  4JI1 E;  2F4V I;  5JEA A;  2NN6 F;  4FWH A;  2UXC E;  3PS3 A;  1N36 E;  1I94 E;  3P3E A;  4LF4 I;  3HKM A;  1QZR A;  1HNX I;  2HHH I;  3QT5 A;  2CG9 A;  1XNR I;  2O1U A;  1HNZ E;  1OYR A;  3L7Z A;  5DRP A;  2Z5C A;  4LF7 E;  2PO2 B;  3ZM7 A;  2JE6 B;  2NPF A;  2BA0 D;  4DV1 E;  2E5L E;  4LF8 E;  2BR2 A;  5JEA E;  4GKK E;  4OKG A;  4JI7 I;  4DR3 E;  1XMO E;  1Z0E A;  3GME A;  3M7N D;  3Q1Q A;  4YHH E;  3B78 A;  1Z59 A;  4FWD A;  4FN5 A;  4U3D A;  5DNL A;  2PNZ B;  4AM3 A;  5EKW A;  2A2D A;  4DPX A;  4B3T E;  2C39 A;  1S16 A;  1KTV A;  4GQU A;  1Z0G A;  4LF5 I;  2DEI A;  1MX0 A;  4LCF A;  4DV7 I;  2UU9 I;  2IER A;  1HNW I;  3J81 Q;  1N34 I;  3P06 A;  2GO4 A;  4DR4 E;  1ZM4 A;  1UDO A;  4GKJ I;  4Z7C A;  4X62 E;  4LF4 E;  1HNX E;  2HHH E;  3OTO I;  1XNR E;  1IBK I;  2Z5B A;  2C37 B;  1RR9 A;  1XXE A;  2HK3 A;  4X64 I;  2UXD I;  4DV4 I;  5A2Q C;  4DR6 E;  2JEA A;  1KIJ A;  4JI7 E;  5JEA D;  1MU5 A;  5L3J A;  1EI1 A;  1KVK A;  4HAC A;  1ELO A;  1H72 C;  5K36 A;  1Z5C A;  3WU6 A;  2WW4 A;  1KKH A;  4QNK A;  2UUA I;  4DV3 I;  1DAR A;  4QNJ A;  4AIM A;  2XEX A;  4JI6 I;  3B82 A;  2E1R A;  1Z0W A;  4DV7 E;  2UU9 E;  1N32 I;  1HNW E;  3WU4 A;  1N34 E;  1N36 I;  5C0X B;  4GKJ E;  1H7U A;  3KRN A;  3NZK A;  5K36 E;  5C0X C;  3OTO E;  2JEB B;  4J3D A;  2OI2 A;  4DR2 I;  4LF7 I;  5GME A;  4IFD A;  4DV1 I;  4LF8 I;  3J81 C;  3CDJ A;  2J65 A;  3JAM Q;  4X64 E;  2UXD E;  4X66 I;  4DV4 E;  5FLX Q;  5DRO A;  4IZK A;  2IES A;  2PO0 B;  3J7A M;  3D4J A;  3PS2 A;  4BA2 A;  4DV0 I;  5ELW A;  4JI8 I;  2UUA E;  2WNR A;  4DV3 E;  1R6M A;  4DUY I;  5BR8 I;  1ZM2 A;  1UDN A;  4IFD E;  4JYA E;  4B3M E;  4K0K E;  4U3B A;  1VIS A;  3WU5 A;  4JI6 E;  1E3P A;  4DR4 I;  4LFA I;  2C38 B;  2Q2E B;  1N32 E;  5A2Q Q;  4OO1 A;  4EMD A;  4JV5 E;  4X62 I;  4HXZ A;  5DRQ A;  1E3H A;  4MU0 A;  5IWA I;  2VQF E;  4NXM I;  3K85 A;  2VF3 A;  3PYD A;  4DR2 E;  5K36 D;  2X7I A;  3WU3 A;  1S4E A;  3PRY A;  3K1J A; 
#chains in the Genus database with same CATH homology
 2GO3 A;  4IS9 A;  4LCG A;  3U1Y A;  3UHM A;  2JT2 A;  2O3Z A;  1YHC A;  4MDT A;  4OKG A;  4U3B A;  4FW5 A;  4LCH A;  4J3D A;  2VES A;  3PS3 A;  4FW4 A;  2J65 A;  3P3E A;  4U3D A;  3P76 A;  4OZE A;  1XXE A;  4ISA A;  5DRR A;  5DRQ A;  3P3G A;  4FW3 A;  5DRO A;  4MQY A;  4FW7 A;  3P3C A;  5DRP A;  2IES A;  1P42 A;  4LCF A;  2IER A;  3PS2 A;  3NZK A;  2GO4 A;  1YH8 A;  3PS1 A;  4FW6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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