4FW7A

Crystal structure of the lpxc in complex with n-[(2s,3r)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]biphenyl-4-carboxamide inhibitor
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
301
structure length
301
Chain Sequence
NAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the LpxC
rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 93
structure length 301
sequence length 301
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw7A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw7A02
3P76A 4FW3A 4LCFA 3U1YA 3NZKA 4FW5A 1XXEA 2GO4A 2IERA 3P3GA 3PS3A 4U3BA 4ISAA 4LCHA 4FW7A 3PS1A 3UHMA 2O3ZA 4MDTA 3PS2A 1YHCA 5DRRA 2JT2A 5DRPA 1YH8A 4OZEA 4J3DA 2IESA 4IS9A 5DRQA 5DROA 3P3EA 4MQYA 3P3CA 4LCGA 1P42A 2J65A 2VESA 4U3DA 4FW4A 4OKGA 2GO3A 4FW6A
chains in the Genus database with same CATH superfamily
4LFBE 3B78A 3NZKA 3PS3A 4DV3E 2UXCE 4YY3E 2PO0B 1USVA 2AE8A 4WUBA 3UHMA 4DR1I 1IBKI 1H72C 2PNZA 4IFDB 1EI1A 2ZBKB 5L3JA 4DR7E 5K36F 5DRQA 2V2ZA 3LTOA 5DROA 2JEAA 4QNKA 1UDSA 4UT4A 1ZM3A 1H74A 1ZM2A 5FWKA 1B62A 4JYAI 3J81Q 4DPTA 4ISAA 4KQVA 1NHJA 3CDIA 1HNXE 1XNRE 4JYAE 1OYSA 3DD6A 4LF7E 2F4VI 2CVEA 2VQFI 5LMUE 1KIJA 5K36E 1N0UA 4DV4I 4B3SE 2Q2EB 5GMEA 1N33E 2Z5BB 4LF6E 4DR4I 4LCGA 3M85G 4BA1A 4FW9A 3J80C 1PVGA 3QT8A 3GCMA 4DV1E 4HACB 4DV2I 1QZRA 4LF8I 4FW5A 2HKEA 5IWAE 4RPFA 4JI2E 2V2VA 4AQYI 4JI3I 2WW4A 1FWLA 1NHHA 4HY1A 2PO2B 5C0XE 4B3MI 2XEXA 4KHPE 3ZZUA 2JE6B 3P3CA 3Q6NA 4JI5E 4U3DA 2C38A 4WUCA 4OX9E 2F1DA 1EA6A 1FJGE 2UXDI 4X66I 4ZVIA 3U1YA 1Y6ZA 3M7ND 1Z0TA 4LCHA 2NN6D 2NN6C 4X66E 2C39A 2HK2A 4MDTA 4JI6I 2NN6E 4IZJD 2O1WA 1ZXMA 2C37A 1Y4SA 4FN5A 2VQFE 4LF9I 1Z0CA 3LNUA 5JEAF 1Z5CA 4FW4A 3F0NA 4DV3I 4GKKE 5C0XA 1HK7A 3P76A 4NXNE 1VISA 1XXEA 2X36A 2PO1A 4DR4E 5C0XD 4DPUA 5C0XC 2DEIA 3HULA 4R1FA 3PYGA 4PU9A 1IBLI 4DV1I 5C0XF 5LL6R 1U2RA 1HNXI 4DV6I 4JI2I 4LF5I 1XMQE 2UU9I 4NXME 1XNRI 2BA0D 1E3HA 2VESA 3ZM7A 1Z0WA 4KHPI 4JV5I 2NN6A 1KVKA 4B3SI 4LCFA 4DU7A 4GKJI 3KRNA 5LMUI 4N3OA 1NZ0A 3ZZTA 1NHIA 3JAMQ 3T1YE 4JI8E 5K36C 2ZITA 1IBMI 3L7ZA 5C0XB 1UEKA 2HKJA 2UUAE 4FWGA 4JI8I 2HHHI 2UXBE 4FWDA 1N32I 4JI6E 3GONA 4X64E 3P3EA 4EMDA 2J7KA 4DV2E 3T1HE 3QT7A 1H7UA 5IWAI 4DV5E 4BA1B 2IOPA 2V34A 1I94E 4B3ME 4K0KI 1H7SA 1Z59A 1Y5YA 4JG4A 3T1HI 2GO4A 4B3TE 4DV5I 1OJ4A 5LMNI 1N36E 4OO1A 4AIMA 4K0KE 3ZKBA 3U1KA 1Z0BA 4MU4A 4LFBI 2WP8B 2JE6A 3K1JA 1Z5AA 2AJ4A 3B4TA 4JI0I 1K47A 4MQYA 3D4JA 4OO1C 5K36B 2V2QA 2VQEI 1Y4UA 1MG7A 5JEAD 4DV0E 2EFGA 2UU9E 2C39B 2V8PA 4LF9E 2R42A 2NPFA 4DV7I 4NXMI 3PS1A 2X7IA 1KKHA 3PS2A 3LPSA 2C37B 5DRRA 4IFDE 4DR6I 3B8HA 4GKKI 3PYDA 4USKA 3PYEA 2BM0A 1PKPA 2IESA 4MU3A 4ED4A 2F4VE 5BR8I 3WU3A 3WU5A 4DUZI 4OO1E 5K36A 3JAMC 5ELWA 5BR8E 5EL9A 1USUA 4AM3A 4LFCE 2O1VA 4GQUA 2BM1A 2PNLA 1YH8A 2UUCE 4MU0A 4P7AA 1FWKA 4DR3E 4JV5E 5A2QC 4URLA 4JI3E 1N36I 2PO0A 4DUYI 4JI4I 4YHHE 1MU5A 4X65I 2PNZB 4IFDA 2A2CA 4IZKB 3QT5A 1RR9A 3H1CA 4X62E 1IBME 5JEAA 2O1TA 4JI5I 4JI0E 4IZKA 1D6TA 3GLLA 4U3BA 2HFUA 4LF6I 1KTVA 2IOQA 2BR2B 2UXBI 3PRYA 3K17A 2BA1D 5EKWA 2UUBE 4FWHA 4Z7YA 2GS8A 4IS9A 2LJPA 2DEJA 2O1UA 4LF7I 5DNXA 1BKNA 4YY3I 2UXCI 1UDOA 3V5RA 4OO1D 4DR6E 4OKGA 4DV4E 4LOMA 1WUUA 2NN6B 2E1RA 2WNRA 1HR0I 5JEAB 3P3GA 4OO1F 5IT9Q 4LPFA 4DR7I 4USMA 4HXZA 4DPWA 3M85D 2CG9A 1VI7A 4NXNI 5DNLA 4PRXA 2WNRB 2Z5BA 2C38B 1P42A 4B3RE 2VF3A 3L7ZB 4DV0I 1UDNA 4DR3I 4LFAI 4DV6E 3V2UC 1J5EI 4JI4E 4Z7CA 4LF5E 3WU4A 3ZZ0A 4M1KA 2JEAB 1J5EE 2CGEA 1N33I 2O3ZA 4I3HA 1HNWI 1YHCA 4OX9I 1FJGI 2UXDE 2JT2A 2PO2A 3CDJA 1FI4A 4JI1I 3M6AA 4PRVA 4DUZE 1A6FA 4DPYA 2JEBB 1H73A 4JI7E 3Q1QA 4LF8E 3M7NG 2HHHE 4NBQA 1R6MA 1FNMA 2HK3A 4IFDF 1S16A 1HNZI 1DARA 1Z5BA 3WU6A 3J7AM 2BA0G 4DR2I 1N34E 2A2DA 4DR5I 4DUYE 4FW7A 2PO1B 2Z5CA 1HR0E 1XMOI 2HFSA 4OZEA 4J3DA 4YHHI 4BA2B 4UTGA 4WUDA 2E5LI 1XNQE 1MX0A 4B3TI 3CWVA 4BA2A 3ZKDA 4IZJA 3T1YI 4QNJA 2E5LE 1XNQI 2GO3A 1IBLE 1FKAE 4FW6A 5IT9C 2R3VA 2UUBI 4LF4I 2BR2A 4XTJA 4LFAE 2VQEE 2BA1G 4B3RI 2Z5EA 5K36D 1ZM9A 3PYFA 4LF4E 3GMEA 5DRPA 1I94I 3J81C 4P52A 3J7AG 1OYPA 1RHYA 4DV7E 1B63A 1ZM4A 4IZJB 1RREA 4MU1A 4DPXA 1ZXNA 2CZ9A 2PNMA 1Y60A 2UUAI 1R6LA 4JI1E 1XHKA 3OTOI 4DR1E 1IBKE 1E3PA 2IERA 5FLXC 4HACA 4JI7I 3HKMA 1XMQI 1S4EA 3OTOE 1Z0EA 2WP8A 5A2QQ 5GMDA 4LFCI 1ELOA 5LMNE 1Z0GA 1Z0VA 1PIEA 1UDQA 3HJCA 1OYRA 4GKJE 2J65A 4DXLA 4OO1B 3P06A 3Q6MA 4HYMA 1N0VC 2UUCI 5FLXQ 4FW3A 1HNWE 3J80Q 5JEAC 2OI2A 2JEBA 4IFDD 4MYTA 4IFDC 2ZM6I 4X62I 1N32E 4X64I 4X65E 3QT6A 1HNZE 5JEAE 2ZM6E 2BV3A 4DU8A 3B82A 4MYUA 3K85A 4AQYE 4AIDA 4DR2E 1N34I 4DR5E 2Z5CB 2GQ0A 3H4LA 2NN6F 1XMOE
chains in the Genus database with same CATH topology
3P76A 4FW3A 4LCFA 3U1YA 3NZKA 4FW5A 1XXEA 2GO4A 2IERA 3P3GA 3PS3A 4U3BA 4ISAA 4LCHA 4FW7A 3PS1A 3UHMA 2O3ZA 4MDTA 3PS2A 1YHCA 5DRRA 2JT2A 5DRPA 1YH8A 4OZEA 4J3DA 2IESA 4IS9A 5DRQA 5DROA 3P3EA 4MQYA 3P3CA 4LCGA 1P42A 2J65A 2VESA 4U3DA 4FW4A 4OKGA 2GO3A 4FW6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P76 A;  4FW3 A;  4LCF A;  3U1Y A;  3NZK A;  4FW5 A;  1XXE A;  2GO4 A;  2IER A;  3P3G A;  3PS3 A;  4U3B A;  4ISA A;  4LCH A;  4FW7 A;  3PS1 A;  3UHM A;  2O3Z A;  4MDT A;  3PS2 A;  1YHC A;  5DRR A;  2JT2 A;  5DRP A;  1YH8 A;  4OZE A;  4J3D A;  2IES A;  4IS9 A;  5DRQ A;  5DRO A;  3P3E A;  4MQY A;  3P3C A;  4LCG A;  1P42 A;  2J65 A;  2VES A;  4U3D A;  4FW4 A;  4OKG A;  2GO3 A;  4FW6 A; 
#chains in the Genus database with same CATH topology
 4LFB E;  3B78 A;  3NZK A;  3PS3 A;  4DV3 E;  2UXC E;  4YY3 E;  2PO0 B;  1USV A;  2AE8 A;  4WUB A;  3UHM A;  4DR1 I;  1IBK I;  1H72 C;  2PNZ A;  4IFD B;  1EI1 A;  2ZBK B;  5L3J A;  4DR7 E;  5K36 F;  5DRQ A;  2V2Z A;  3LTO A;  5DRO A;  2JEA A;  4QNK A;  1UDS A;  4UT4 A;  1ZM3 A;  1H74 A;  1ZM2 A;  5FWK A;  1B62 A;  4JYA I;  3J81 Q;  4DPT A;  4ISA A;  4KQV A;  1NHJ A;  3CDI A;  1HNX E;  1XNR E;  4JYA E;  1OYS A;  3DD6 A;  4LF7 E;  2F4V I;  2CVE A;  2VQF I;  5LMU E;  1KIJ A;  5K36 E;  1N0U A;  4DV4 I;  4B3S E;  2Q2E B;  5GME A;  1N33 E;  2Z5B B;  4LF6 E;  4DR4 I;  4LCG A;  3M85 G;  4BA1 A;  4FW9 A;  3J80 C;  1PVG A;  3QT8 A;  3GCM A;  4DV1 E;  4HAC B;  4DV2 I;  1QZR A;  4LF8 I;  4FW5 A;  2HKE A;  5IWA E;  4RPF A;  4JI2 E;  2V2V A;  4AQY I;  4JI3 I;  2WW4 A;  1FWL A;  1NHH A;  4HY1 A;  2PO2 B;  5C0X E;  4B3M I;  2XEX A;  4KHP E;  3ZZU A;  2JE6 B;  3P3C A;  3Q6N A;  4JI5 E;  4U3D A;  2C38 A;  4WUC A;  4OX9 E;  2F1D A;  1EA6 A;  1FJG E;  2UXD I;  4X66 I;  4ZVI A;  3U1Y A;  1Y6Z A;  3M7N D;  1Z0T A;  4LCH A;  2NN6 D;  2NN6 C;  4X66 E;  2C39 A;  2HK2 A;  4MDT A;  4JI6 I;  2NN6 E;  4IZJ D;  2O1W A;  1ZXM A;  2C37 A;  1Y4S A;  4FN5 A;  2VQF E;  4LF9 I;  1Z0C A;  3LNU A;  5JEA F;  1Z5C A;  4FW4 A;  3F0N A;  4DV3 I;  4GKK E;  5C0X A;  1HK7 A;  3P76 A;  4NXN E;  1VIS A;  1XXE A;  2X36 A;  2PO1 A;  4DR4 E;  5C0X D;  4DPU A;  5C0X C;  2DEI A;  3HUL A;  4R1F A;  3PYG A;  4PU9 A;  1IBL I;  4DV1 I;  5C0X F;  5LL6 R;  1U2R A;  1HNX I;  4DV6 I;  4JI2 I;  4LF5 I;  1XMQ E;  2UU9 I;  4NXM E;  1XNR I;  2BA0 D;  1E3H A;  2VES A;  3ZM7 A;  1Z0W A;  4KHP I;  4JV5 I;  2NN6 A;  1KVK A;  4B3S I;  4LCF A;  4DU7 A;  4GKJ I;  3KRN A;  5LMU I;  4N3O A;  1NZ0 A;  3ZZT A;  1NHI A;  3JAM Q;  3T1Y E;  4JI8 E;  5K36 C;  2ZIT A;  1IBM I;  3L7Z A;  5C0X B;  1UEK A;  2HKJ A;  2UUA E;  4FWG A;  4JI8 I;  2HHH I;  2UXB E;  4FWD A;  1N32 I;  4JI6 E;  3GON A;  4X64 E;  3P3E A;  4EMD A;  2J7K A;  4DV2 E;  3T1H E;  3QT7 A;  1H7U A;  5IWA I;  4DV5 E;  4BA1 B;  2IOP A;  2V34 A;  1I94 E;  4B3M E;  4K0K I;  1H7S A;  1Z59 A;  1Y5Y A;  4JG4 A;  3T1H I;  2GO4 A;  4B3T E;  4DV5 I;  1OJ4 A;  5LMN I;  1N36 E;  4OO1 A;  4AIM A;  4K0K E;  3ZKB A;  3U1K A;  1Z0B A;  4MU4 A;  4LFB I;  2WP8 B;  2JE6 A;  3K1J A;  1Z5A A;  2AJ4 A;  3B4T A;  4JI0 I;  1K47 A;  4MQY A;  3D4J A;  4OO1 C;  5K36 B;  2V2Q A;  2VQE I;  1Y4U A;  1MG7 A;  5JEA D;  4DV0 E;  2EFG A;  2UU9 E;  2C39 B;  2V8P A;  4LF9 E;  2R42 A;  2NPF A;  4DV7 I;  4NXM I;  3PS1 A;  2X7I A;  1KKH A;  3PS2 A;  3LPS A;  2C37 B;  5DRR A;  4IFD E;  4DR6 I;  3B8H A;  4GKK I;  3PYD A;  4USK A;  3PYE A;  2BM0 A;  1PKP A;  2IES A;  4MU3 A;  4ED4 A;  2F4V E;  5BR8 I;  3WU3 A;  3WU5 A;  4DUZ I;  4OO1 E;  5K36 A;  3JAM C;  5ELW A;  5BR8 E;  5EL9 A;  1USU A;  4AM3 A;  4LFC E;  2O1V A;  4GQU A;  2BM1 A;  2PNL A;  1YH8 A;  2UUC E;  4MU0 A;  4P7A A;  1FWK A;  4DR3 E;  4JV5 E;  5A2Q C;  4URL A;  4JI3 E;  1N36 I;  2PO0 A;  4DUY I;  4JI4 I;  4YHH E;  1MU5 A;  4X65 I;  2PNZ B;  4IFD A;  2A2C A;  4IZK B;  3QT5 A;  1RR9 A;  3H1C A;  4X62 E;  1IBM E;  5JEA A;  2O1T A;  4JI5 I;  4JI0 E;  4IZK A;  1D6T A;  3GLL A;  4U3B A;  2HFU A;  4LF6 I;  1KTV A;  2IOQ A;  2BR2 B;  2UXB I;  3PRY A;  3K17 A;  2BA1 D;  5EKW A;  2UUB E;  4FWH A;  4Z7Y A;  2GS8 A;  4IS9 A;  2LJP A;  2DEJ A;  2O1U A;  4LF7 I;  5DNX A;  1BKN A;  4YY3 I;  2UXC I;  1UDO A;  3V5R A;  4OO1 D;  4DR6 E;  4OKG A;  4DV4 E;  4LOM A;  1WUU A;  2NN6 B;  2E1R A;  2WNR A;  1HR0 I;  5JEA B;  3P3G A;  4OO1 F;  5IT9 Q;  4LPF A;  4DR7 I;  4USM A;  4HXZ A;  4DPW A;  3M85 D;  2CG9 A;  1VI7 A;  4NXN I;  5DNL A;  4PRX A;  2WNR B;  2Z5B A;  2C38 B;  1P42 A;  4B3R E;  2VF3 A;  3L7Z B;  4DV0 I;  1UDN A;  4DR3 I;  4LFA I;  4DV6 E;  3V2U C;  1J5E I;  4JI4 E;  4Z7C A;  4LF5 E;  3WU4 A;  3ZZ0 A;  4M1K A;  2JEA B;  1J5E E;  2CGE A;  1N33 I;  2O3Z A;  4I3H A;  1HNW I;  1YHC A;  4OX9 I;  1FJG I;  2UXD E;  2JT2 A;  2PO2 A;  3CDJ A;  1FI4 A;  4JI1 I;  3M6A A;  4PRV A;  4DUZ E;  1A6F A;  4DPY A;  2JEB B;  1H73 A;  4JI7 E;  3Q1Q A;  4LF8 E;  3M7N G;  2HHH E;  4NBQ A;  1R6M A;  1FNM A;  2HK3 A;  4IFD F;  1S16 A;  1HNZ I;  1DAR A;  1Z5B A;  3WU6 A;  3J7A M;  2BA0 G;  4DR2 I;  1N34 E;  2A2D A;  4DR5 I;  4DUY E;  4FW7 A;  2PO1 B;  2Z5C A;  1HR0 E;  1XMO I;  2HFS A;  4OZE A;  4J3D A;  4YHH I;  4BA2 B;  4UTG A;  4WUD A;  2E5L I;  1XNQ E;  1MX0 A;  4B3T I;  3CWV A;  4BA2 A;  3ZKD A;  4IZJ A;  3T1Y I;  4QNJ A;  2E5L E;  1XNQ I;  2GO3 A;  1IBL E;  1FKA E;  4FW6 A;  5IT9 C;  2R3V A;  2UUB I;  4LF4 I;  2BR2 A;  4XTJ A;  4LFA E;  2VQE E;  2BA1 G;  4B3R I;  2Z5E A;  5K36 D;  1ZM9 A;  3PYF A;  4LF4 E;  3GME A;  5DRP A;  1I94 I;  3J81 C;  4P52 A;  3J7A G;  1OYP A;  1RHY A;  4DV7 E;  1B63 A;  1ZM4 A;  4IZJ B;  1RRE A;  4MU1 A;  4DPX A;  1ZXN A;  2CZ9 A;  2PNM A;  1Y60 A;  2UUA I;  1R6L A;  4JI1 E;  1XHK A;  3OTO I;  4DR1 E;  1IBK E;  1E3P A;  2IER A;  5FLX C;  4HAC A;  4JI7 I;  3HKM A;  1XMQ I;  1S4E A;  3OTO E;  1Z0E A;  2WP8 A;  5A2Q Q;  5GMD A;  4LFC I;  1ELO A;  5LMN E;  1Z0G A;  1Z0V A;  1PIE A;  1UDQ A;  3HJC A;  1OYR A;  4GKJ E;  2J65 A;  4DXL A;  4OO1 B;  3P06 A;  3Q6M A;  4HYM A;  1N0V C;  2UUC I;  5FLX Q;  4FW3 A;  1HNW E;  3J80 Q;  5JEA C;  2OI2 A;  2JEB A;  4IFD D;  4MYT A;  4IFD C;  2ZM6 I;  4X62 I;  1N32 E;  4X64 I;  4X65 E;  3QT6 A;  1HNZ E;  5JEA E;  2ZM6 E;  2BV3 A;  4DU8 A;  3B82 A;  4MYU A;  3K85 A;  4AQY E;  4AID A;  4DR2 E;  1N34 I;  4DR5 E;  2Z5C B;  2GQ0 A;  3H4L A;  2NN6 F;  1XMO E; 
#chains in the Genus database with same CATH homology
 3P76 A;  4FW3 A;  4LCF A;  3U1Y A;  3NZK A;  4FW5 A;  1XXE A;  2GO4 A;  2IER A;  3P3G A;  3PS3 A;  4U3B A;  4ISA A;  4LCH A;  4FW7 A;  3PS1 A;  3UHM A;  2O3Z A;  4MDT A;  3PS2 A;  1YHC A;  5DRR A;  2JT2 A;  5DRP A;  1YH8 A;  4OZE A;  4J3D A;  2IES A;  4IS9 A;  5DRQ A;  5DRO A;  3P3E A;  4MQY A;  3P3C A;  4LCG A;  1P42 A;  2J65 A;  2VES A;  4U3D A;  4FW4 A;  4OKG A;  2GO3 A;  4FW6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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