4FW7A

Crystal structure of the lpxc in complex with n-[(2s,3r)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]biphenyl-4-carboxamide inhibitor
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
301
structure length
301
Chain Sequence
NAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the LpxC
rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 93
structure length 301
sequence length 301
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw7A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw7A02
3UHMA 4LCGA 4ISAA 2J65A 3P3CA 3PS1A 4OKGA 1P42A 5DRPA 4U3DA 1YH8A 3P76A 3U1YA 1XXEA 3P3GA 4MDTA 2IERA 5DROA 3P3EA 4LCHA 4LCFA 4J3DA 4OZEA 4FW3A 4U3BA 2O3ZA 5DRRA 4FW6A 5DRQA 3PS3A 4FW5A 1YHCA 2VESA 4FW4A 2GO3A 4FW7A 2JT2A 2GO4A 2IESA 3PS2A 4IS9A 3NZKA 4MQYA
chains in the Genus database with same CATH superfamily
4KQVA 3M85G 1S16A 4AIDA 2VQFI 2UUBI 2V8PA 4X65E 4FWHA 2PO1A 2HHHE 3WU4A 2VQEE 1KTVA 2V34A 4LCHA 2Z5CA 3PYGA 4JI7E 2BR2B 2O1VA 5DRRA 4X65I 1HNWI 4FN5A 1NHHA 4JYAE 1N34I 1PKPA 4OO1C 3PYDA 2WW4A 1BKNA 5FLXC 3KRNA 3LPSA 1HK7A 1HNWE 3UHMA 4K0KE 1IBLI 1MX0A 4ISAA 5JEAE 2A2CA 4KHPI 2PO0B 4YHHI 2HFSA 4JI3I 5DRPA 4X62E 1ZXMA 1Y5YA 2BA0D 1USUA 3PRYA 4BA1B 1DARA 1OYRA 3CDIA 4OZEA 4DR7E 4ED4A 2J7KA 5JEAC 4B3TE 2F4VE 4URLA 4DR5I 1OYPA 3DD6A 5K36B 4X66E 5L3JA 1N0VC 4HY1A 1N36E 4LFCE 1KVKA 2PO2B 2IESA 1MG7A 4LF5I 4IZJA 4DV4E 2JE6B 4JI0I 2CGEA 3ZKDA 4DV0E 4LFBE 2JE6A 4DR5E 1N36I 1RHYA 4GKJE 4JG4A 4AM3A 2UXCI 4LF4I 3V2UC 5K36D 1N33I 5ELWA 4J3DA 3M7NG 4DU7A 4JI6E 4FW6A 2UXBI 4LFAE 5LMUI 2UXCE 4WUBA 4AIMA 4QNJA 1USVA 4BA1A 2PO0A 1ZXNA 1Y4SA 4LFAI 2ZM6I 2V2VA 1N32E 1XNQE 2Z5CB 3OTOE 3HKMA 4X66I 1S4EA 2BA1G 4LF9I 4ZVIA 4DR4E 2NN6D 1H7UA 5IT9Q 3QT5A 4IZJD 3P06A 1FJGE 2EFGA 1R6MA 5A2QQ 1HNZE 4DR2I 2R3VA 2Z5BB 4Z7CA 3Q1QA 2JEBA 1ELOA 3B8HA 3Q6NA 4DR1E 2V2ZA 4DV3I 1EA6A 1Y4UA 4R1FA 4U3DA 4FW9A 1E3HA 4JI2I 4DV1E 3J7AM 1RR9A 4DV5E 1UEKA 3H1CA 2HFUA 3U1KA 5BR8I 4LCFA 3J81Q 2C39B 4LF6E 4DPYA 4M1KA 4JI2E 1OJ4A 2BM1A 5K36F 2GS8A 2R42A 4IFDF 4JI7I 1N0UA 2NN6B 1D6TA 3P3CA 4OKGA 1P42A 2C38B 2BV3A 4LF7E 1N34E 1FI4A 5EL9A 4HYMA 4NBQA 2UUAE 1ZM4A 2WP8B 3GONA 2NN6E 2OI2A 4RPFA 4JI3E 1EI1A 1FKAE 4HACB 1UDOA 2VF3A 4DV6E 1Z0TA 1R6LA 2ZITA 2WNRA 5LMNI 4AQYI 2GQ0A 1Z5BA 3T1YI 5GMDA 4JI8I 2NPFA 4NXNE 3T1HE 4OO1B 3U1YA 3B82A 4B3ME 4JI0E 2IERA 5DROA 2HK2A 4LF5E 4K0KI 1Z0VA 2ZBKB 4NXNI 2BA1D 3PYFA 4X64I 3ZZ0A 1Z59A 4JI8E 1FWKA 1K47A 2AE8A 4Z7YA 3HJCA 3B4TA 4MU1A 1UDNA 4I3HA 4X62I 1NHJA 2WNRB 1HR0E 2DEIA 1I94I 4OO1E 4JI5I 2UUAI 1UDQA 3WU6A 4DUZI 5K36C 2JEAA 2PNLA 4IFDA 1H73A 4DV4I 2F1DA 2BM0A 1IBMI 4DV7I 4PRVA 1VISA 1XMQI 4DV0I 4LFBI 3F0NA 4PU9A 4OO1A 2JT2A 1U2RA 4IS9A 2Q2EB 4FWDA 1XMQE 4YY3I 4DR6I 4DR7I 4LPFA 4LF4E 4IFDD 1IBME 4DR2E 5K36A 5C0XC 5FWKA 5LMUE 2PNZB 3B78A 3JAMQ 4MYTA 4JI4E 4YY3E 4UTGA 4IZJB 2WP8A 1RREA 1ZM9A 2A2DA 3CWVA 4WUCA 2O3ZA 2E5LE 5FLXQ 3L7ZB 4FW5A 1XNQI 1N32I 1OYSA 4MYUA 1IBKE 4HACA 4OO1F 4FW7A 4DUZE 4DV2E 3QT7A 5K36E 5A2QC 4GKJI 1A6FA 3K1JA 4MQYA 1J5EE 1XNRI 1XMOE 2J65A 2C37A 3J81C 4JI6I 2E1RA 1Y60A 4DR4I 2LJPA 2NN6C 2NN6A 4WUDA 3J80C 3P3EA 1HNXI 2V2QA 4LF8E 3ZM7A 2X36A 4DR3E 3ZKBA 4MU4A 5C0XF 2PO2A 4FWGA 4DV5I 1HNXE 2VQEI 2CVEA 2IOPA 1B63A 4NXMI 1E3PA 5BR8E 1VI7A 5DNLA 4BA2A 2Z5BA 4IFDB 4NXME 4DV6I 2UU9I 3M7ND 3M85D 4IZKB 4DU8A 4FW3A 5IWAI 3PS3A 1XMOI 4GKKI 2VQFE 4QNKA 3K85A 2UUBE 2HHHI 5IWAE 3NZKA 2UU9E 2Z5EA 4OO1D 4GKKE 1Z0GA 4LF8I 4X64E 1KKHA 4JYAI 3WU5A 4B3SI 3D4JA 1HR0I 3P3GA 1I94E 5JEAA 1NHIA 4MDTA 1IBLE 4LOMA 4JI5E 4DUYE 3T1YE 4U3BA 2DEJA 1B62A 5LMNE 5C0XE 3HULA 4B3SE 4IFDE 3ZZUA 2PNMA 2BA0G 4YHHE 4FW4A 4B3MI 1ZM2A 3GLLA 2C38A 3H4LA 5JEAB 5LL6R 4DUYI 4LCGA 1FNMA 4DPTA 3PS1A 2UUCE 1YH8A 4DPUA 4DXLA 4OX9E 4LFCI 2NN6F 2HKJA 1H72C 1FWLA 3J7AG 1Z0CA 4P7AA 4DR6E 5DRQA 5C0XD 2IOQA 4USMA 4OX9I 4JI4I 4KHPE 3T1HI 1PVGA 2UUCI 3LTOA 4MU3A 4LF9E 2GO4A 2O1TA 2UXBE 2X7IA 5JEAD 1PIEA 2JEAB 1FJGI 4DV7E 3P76A 1KIJA 2O1UA 2UXDI 5EKWA 5C0XA 4P52A 4JV5I 2JEBB 3GMEA 3CDJA 1XNRE 1MU5A 2UXDE 4DPXA 5C0XB 2VESA 2PO1B 1Y6ZA 2GO3A 2CG9A 4JI1I 2XEXA 1N33E 4LF6I 1Z0EA 1ZM3A 4HXZA 5JEAF 1XHKA 2E5LI 2BR2A 4MU0A 3QT6A 4IZKA 3L7ZA 5DNXA 3PYEA 2C37B 1QZRA 4BA2B 3Q6MA 4XTJA 4B3RE 3J80Q 1H7SA 2ZM6E 2PNZA 1J5EI 3V5RA 4LF7I 4N3OA 1H74A 3QT8A 1UDSA 1YHCA 3ZZTA 4UT4A 4IFDC 4DV1I 1WUUA 2HK3A 4B3RI 1Z5CA 3PS2A 5IT9C 3K17A 3OTOI 4GQUA 4PRXA 4JV5E 4USKA 1Z5AA 2AJ4A 4DR3I 1Z0WA 1IBKI 1XXEA 2C39A 2HKEA 1HNZI 1NZ0A 4DV2I 4AQYE 4JI1E 4DV3E 3GCMA 3M6AA 2O1WA 4DR1I 4EMDA 3WU3A 4DPWA 1Z0BA 4B3TI 2F4VI 3JAMC 2CZ9A 3LNUA 5GMEA
chains in the Genus database with same CATH topology
3UHMA 4LCGA 4ISAA 2J65A 3P3CA 3PS1A 4OKGA 1P42A 5DRPA 4U3DA 1YH8A 3P76A 3U1YA 1XXEA 3P3GA 4MDTA 2IERA 5DROA 3P3EA 4LCHA 4LCFA 4J3DA 4OZEA 4FW3A 4U3BA 2O3ZA 5DRRA 4FW6A 5DRQA 3PS3A 4FW5A 1YHCA 2VESA 4FW4A 2GO3A 4FW7A 2JT2A 2GO4A 2IESA 3PS2A 4IS9A 3NZKA 4MQYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UHM A;  4LCG A;  4ISA A;  2J65 A;  3P3C A;  3PS1 A;  4OKG A;  1P42 A;  5DRP A;  4U3D A;  1YH8 A;  3P76 A;  3U1Y A;  1XXE A;  3P3G A;  4MDT A;  2IER A;  5DRO A;  3P3E A;  4LCH A;  4LCF A;  4J3D A;  4OZE A;  4FW3 A;  4U3B A;  2O3Z A;  5DRR A;  4FW6 A;  5DRQ A;  3PS3 A;  4FW5 A;  1YHC A;  2VES A;  4FW4 A;  2GO3 A;  4FW7 A;  2JT2 A;  2GO4 A;  2IES A;  3PS2 A;  4IS9 A;  3NZK A;  4MQY A; 
#chains in the Genus database with same CATH topology
 4KQV A;  3M85 G;  1S16 A;  4AID A;  2VQF I;  2UUB I;  2V8P A;  4X65 E;  4FWH A;  2PO1 A;  2HHH E;  3WU4 A;  2VQE E;  1KTV A;  2V34 A;  4LCH A;  2Z5C A;  3PYG A;  4JI7 E;  2BR2 B;  2O1V A;  5DRR A;  4X65 I;  1HNW I;  4FN5 A;  1NHH A;  4JYA E;  1N34 I;  1PKP A;  4OO1 C;  3PYD A;  2WW4 A;  1BKN A;  5FLX C;  3KRN A;  3LPS A;  1HK7 A;  1HNW E;  3UHM A;  4K0K E;  1IBL I;  1MX0 A;  4ISA A;  5JEA E;  2A2C A;  4KHP I;  2PO0 B;  4YHH I;  2HFS A;  4JI3 I;  5DRP A;  4X62 E;  1ZXM A;  1Y5Y A;  2BA0 D;  1USU A;  3PRY A;  4BA1 B;  1DAR A;  1OYR A;  3CDI A;  4OZE A;  4DR7 E;  4ED4 A;  2J7K A;  5JEA C;  4B3T E;  2F4V E;  4URL A;  4DR5 I;  1OYP A;  3DD6 A;  5K36 B;  4X66 E;  5L3J A;  1N0V C;  4HY1 A;  1N36 E;  4LFC E;  1KVK A;  2PO2 B;  2IES A;  1MG7 A;  4LF5 I;  4IZJ A;  4DV4 E;  2JE6 B;  4JI0 I;  2CGE A;  3ZKD A;  4DV0 E;  4LFB E;  2JE6 A;  4DR5 E;  1N36 I;  1RHY A;  4GKJ E;  4JG4 A;  4AM3 A;  2UXC I;  4LF4 I;  3V2U C;  5K36 D;  1N33 I;  5ELW A;  4J3D A;  3M7N G;  4DU7 A;  4JI6 E;  4FW6 A;  2UXB I;  4LFA E;  5LMU I;  2UXC E;  4WUB A;  4AIM A;  4QNJ A;  1USV A;  4BA1 A;  2PO0 A;  1ZXN A;  1Y4S A;  4LFA I;  2ZM6 I;  2V2V A;  1N32 E;  1XNQ E;  2Z5C B;  3OTO E;  3HKM A;  4X66 I;  1S4E A;  2BA1 G;  4LF9 I;  4ZVI A;  4DR4 E;  2NN6 D;  1H7U A;  5IT9 Q;  3QT5 A;  4IZJ D;  3P06 A;  1FJG E;  2EFG A;  1R6M A;  5A2Q Q;  1HNZ E;  4DR2 I;  2R3V A;  2Z5B B;  4Z7C A;  3Q1Q A;  2JEB A;  1ELO A;  3B8H A;  3Q6N A;  4DR1 E;  2V2Z A;  4DV3 I;  1EA6 A;  1Y4U A;  4R1F A;  4U3D A;  4FW9 A;  1E3H A;  4JI2 I;  4DV1 E;  3J7A M;  1RR9 A;  4DV5 E;  1UEK A;  3H1C A;  2HFU A;  3U1K A;  5BR8 I;  4LCF A;  3J81 Q;  2C39 B;  4LF6 E;  4DPY A;  4M1K A;  4JI2 E;  1OJ4 A;  2BM1 A;  5K36 F;  2GS8 A;  2R42 A;  4IFD F;  4JI7 I;  1N0U A;  2NN6 B;  1D6T A;  3P3C A;  4OKG A;  1P42 A;  2C38 B;  2BV3 A;  4LF7 E;  1N34 E;  1FI4 A;  5EL9 A;  4HYM A;  4NBQ A;  2UUA E;  1ZM4 A;  2WP8 B;  3GON A;  2NN6 E;  2OI2 A;  4RPF A;  4JI3 E;  1EI1 A;  1FKA E;  4HAC B;  1UDO A;  2VF3 A;  4DV6 E;  1Z0T A;  1R6L A;  2ZIT A;  2WNR A;  5LMN I;  4AQY I;  2GQ0 A;  1Z5B A;  3T1Y I;  5GMD A;  4JI8 I;  2NPF A;  4NXN E;  3T1H E;  4OO1 B;  3U1Y A;  3B82 A;  4B3M E;  4JI0 E;  2IER A;  5DRO A;  2HK2 A;  4LF5 E;  4K0K I;  1Z0V A;  2ZBK B;  4NXN I;  2BA1 D;  3PYF A;  4X64 I;  3ZZ0 A;  1Z59 A;  4JI8 E;  1FWK A;  1K47 A;  2AE8 A;  4Z7Y A;  3HJC A;  3B4T A;  4MU1 A;  1UDN A;  4I3H A;  4X62 I;  1NHJ A;  2WNR B;  1HR0 E;  2DEI A;  1I94 I;  4OO1 E;  4JI5 I;  2UUA I;  1UDQ A;  3WU6 A;  4DUZ I;  5K36 C;  2JEA A;  2PNL A;  4IFD A;  1H73 A;  4DV4 I;  2F1D A;  2BM0 A;  1IBM I;  4DV7 I;  4PRV A;  1VIS A;  1XMQ I;  4DV0 I;  4LFB I;  3F0N A;  4PU9 A;  4OO1 A;  2JT2 A;  1U2R A;  4IS9 A;  2Q2E B;  4FWD A;  1XMQ E;  4YY3 I;  4DR6 I;  4DR7 I;  4LPF A;  4LF4 E;  4IFD D;  1IBM E;  4DR2 E;  5K36 A;  5C0X C;  5FWK A;  5LMU E;  2PNZ B;  3B78 A;  3JAM Q;  4MYT A;  4JI4 E;  4YY3 E;  4UTG A;  4IZJ B;  2WP8 A;  1RRE A;  1ZM9 A;  2A2D A;  3CWV A;  4WUC A;  2O3Z A;  2E5L E;  5FLX Q;  3L7Z B;  4FW5 A;  1XNQ I;  1N32 I;  1OYS A;  4MYU A;  1IBK E;  4HAC A;  4OO1 F;  4FW7 A;  4DUZ E;  4DV2 E;  3QT7 A;  5K36 E;  5A2Q C;  4GKJ I;  1A6F A;  3K1J A;  4MQY A;  1J5E E;  1XNR I;  1XMO E;  2J65 A;  2C37 A;  3J81 C;  4JI6 I;  2E1R A;  1Y60 A;  4DR4 I;  2LJP A;  2NN6 C;  2NN6 A;  4WUD A;  3J80 C;  3P3E A;  1HNX I;  2V2Q A;  4LF8 E;  3ZM7 A;  2X36 A;  4DR3 E;  3ZKB A;  4MU4 A;  5C0X F;  2PO2 A;  4FWG A;  4DV5 I;  1HNX E;  2VQE I;  2CVE A;  2IOP A;  1B63 A;  4NXM I;  1E3P A;  5BR8 E;  1VI7 A;  5DNL A;  4BA2 A;  2Z5B A;  4IFD B;  4NXM E;  4DV6 I;  2UU9 I;  3M7N D;  3M85 D;  4IZK B;  4DU8 A;  4FW3 A;  5IWA I;  3PS3 A;  1XMO I;  4GKK I;  2VQF E;  4QNK A;  3K85 A;  2UUB E;  2HHH I;  5IWA E;  3NZK A;  2UU9 E;  2Z5E A;  4OO1 D;  4GKK E;  1Z0G A;  4LF8 I;  4X64 E;  1KKH A;  4JYA I;  3WU5 A;  4B3S I;  3D4J A;  1HR0 I;  3P3G A;  1I94 E;  5JEA A;  1NHI A;  4MDT A;  1IBL E;  4LOM A;  4JI5 E;  4DUY E;  3T1Y E;  4U3B A;  2DEJ A;  1B62 A;  5LMN E;  5C0X E;  3HUL A;  4B3S E;  4IFD E;  3ZZU A;  2PNM A;  2BA0 G;  4YHH E;  4FW4 A;  4B3M I;  1ZM2 A;  3GLL A;  2C38 A;  3H4L A;  5JEA B;  5LL6 R;  4DUY I;  4LCG A;  1FNM A;  4DPT A;  3PS1 A;  2UUC E;  1YH8 A;  4DPU A;  4DXL A;  4OX9 E;  4LFC I;  2NN6 F;  2HKJ A;  1H72 C;  1FWL A;  3J7A G;  1Z0C A;  4P7A A;  4DR6 E;  5DRQ A;  5C0X D;  2IOQ A;  4USM A;  4OX9 I;  4JI4 I;  4KHP E;  3T1H I;  1PVG A;  2UUC I;  3LTO A;  4MU3 A;  4LF9 E;  2GO4 A;  2O1T A;  2UXB E;  2X7I A;  5JEA D;  1PIE A;  2JEA B;  1FJG I;  4DV7 E;  3P76 A;  1KIJ A;  2O1U A;  2UXD I;  5EKW A;  5C0X A;  4P52 A;  4JV5 I;  2JEB B;  3GME A;  3CDJ A;  1XNR E;  1MU5 A;  2UXD E;  4DPX A;  5C0X B;  2VES A;  2PO1 B;  1Y6Z A;  2GO3 A;  2CG9 A;  4JI1 I;  2XEX A;  1N33 E;  4LF6 I;  1Z0E A;  1ZM3 A;  4HXZ A;  5JEA F;  1XHK A;  2E5L I;  2BR2 A;  4MU0 A;  3QT6 A;  4IZK A;  3L7Z A;  5DNX A;  3PYE A;  2C37 B;  1QZR A;  4BA2 B;  3Q6M A;  4XTJ A;  4B3R E;  3J80 Q;  1H7S A;  2ZM6 E;  2PNZ A;  1J5E I;  3V5R A;  4LF7 I;  4N3O A;  1H74 A;  3QT8 A;  1UDS A;  1YHC A;  3ZZT A;  4UT4 A;  4IFD C;  4DV1 I;  1WUU A;  2HK3 A;  4B3R I;  1Z5C A;  3PS2 A;  5IT9 C;  3K17 A;  3OTO I;  4GQU A;  4PRX A;  4JV5 E;  4USK A;  1Z5A A;  2AJ4 A;  4DR3 I;  1Z0W A;  1IBK I;  1XXE A;  2C39 A;  2HKE A;  1HNZ I;  1NZ0 A;  4DV2 I;  4AQY E;  4JI1 E;  4DV3 E;  3GCM A;  3M6A A;  2O1W A;  4DR1 I;  4EMD A;  3WU3 A;  4DPW A;  1Z0B A;  4B3T I;  2F4V I;  3JAM C;  2CZ9 A;  3LNU A;  5GME A; 
#chains in the Genus database with same CATH homology
 3UHM A;  4LCG A;  4ISA A;  2J65 A;  3P3C A;  3PS1 A;  4OKG A;  1P42 A;  5DRP A;  4U3D A;  1YH8 A;  3P76 A;  3U1Y A;  1XXE A;  3P3G A;  4MDT A;  2IER A;  5DRO A;  3P3E A;  4LCH A;  4LCF A;  4J3D A;  4OZE A;  4FW3 A;  4U3B A;  2O3Z A;  5DRR A;  4FW6 A;  5DRQ A;  3PS3 A;  4FW5 A;  1YHC A;  2VES A;  4FW4 A;  2GO3 A;  4FW7 A;  2JT2 A;  2GO4 A;  2IES A;  3PS2 A;  4IS9 A;  3NZK A;  4MQY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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