3P3GA

Crystal structure of the escherichia coli lpxc/lpc-009 complex
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 85
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2010-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3p3gA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3p3gA02
3P3EA 3UHMA 4U3DA 2IESA 3PS2A 4LCGA 4U3BA 3PS1A 3PS3A 2GO3A 1XXEA 4J3DA 4MDTA 1YH8A 4FW4A 3U1YA 2VESA 4OKGA 2GO4A 4FW6A 4LCFA 4MQYA 2JT2A 5DRRA 5DRPA 4ISAA 5DROA 3NZKA 2IERA 4FW7A 5DRQA 4FW3A 4FW5A 2O3ZA 4OZEA 1P42A 2J65A 3P3GA 3P76A 4LCHA 4IS9A 3P3CA 1YHCA
chains in the Genus database with same CATH superfamily
4LF7E 2VQFE 5C0XF 4K0KI 4ED4A 5DNXA 4DPWA 4DV2E 4FW9A 2HK3A 1ZM2A 4DXLA 2C38A 4WUBA 3ZZ0A 1I94I 5K36D 1PKPA 1IBKI 2UU9I 2C39A 1XHKA 1D6TA 5JEAB 2HK2A 3HJCA 3LNUA 4R1FA 2PO0A 4LCHA 2UXBE 4N3OA 1FWKA 4JI2I 1N0VC 4JI6I 4IFDC 4DPXA 4DV0E 4JG4A 3PRYA 4MYTA 3P06A 1Z5BA 2NN6B 1NHIA 3K1JA 5C0XA 2BA0D 3K85A 4YY3I 4DR5E 4JI4I 1Y60A 2VESA 3ZZUA 4X64I 1H72C 5DRRA 4JI1I 4DV5E 1ZM9A 4QNKA 4OX9E 4X62I 4FW5A 4BA1A 1K47A 2GQ0A 4BA2B 4LF5E 4GKJI 1FJGI 4IFDB 4FWGA 2PO2B 4LF6I 1Y5YA 3OTOE 4DPYA 3PS3A 3M85D 4JI3E 5LMNE 2DEJA 4AQYE 1KIJA 1YH8A 4FW4A 2R42A 3L7ZA 3QT8A 1XNRE 3Q1QA 5FWKA 4WUCA 2E5LI 1ZM4A 1XMQE 1ZXMA 2ZM6E 2WP8B 4DUZI 2NN6D 4MYUA 2AE8A 1Y4UA 4JV5E 4NXNE 4DV4E 4B3TI 3M7ND 2PNZA 4UT4A 3ZKBA 3P3CA 1QZRA 1XMOI 2VQEE 1MG7A 4IZKB 4LCGA 4YHHI 3CDIA 4LFCI 4JI7E 1S4EA 3WU5A 1N32E 4DR7I 4DV3I 2HHHI 1A6FA 5FLXQ 4IZJD 3DD6A 1N34I 4X65E 3Q6MA 4PRXA 1EA6A 2Z5BB 2E1RA 2IOQA 3CDJA 4K0KE 3M85G 3GCMA 2UXDI 5GMDA 4IFDA 2R3VA 4JI8E 5LL6R 4IS9A 2UXDE 5C0XE 3QT7A 3P3EA 4DR7E 4AM3A 1Y4SA 4LOMA 1J5EI 5JEAD 2BM1A 3J81Q 2UUAI 2JEAA 1WUUA 3B4TA 1HR0E 2HHHE 4DPUA 3T1HI 1KVKA 1VI7A 4GKKI 3L7ZB 5L3JA 2JEBA 2VQEI 4IZJB 1HNZE 4DV6I 2X7IA 5JEAC 4OO1F 2PO2A 2ZBKB 2C37A 4DU8A 5JEAE 1E3HA 2A2DA 1HNZI 1XMQI 2WW4A 3B82A 4IZKA 1Z0EA 1FJGE 1DARA 2BR2B 2BA0G 2NN6F 4GKKE 4B3SE 4DUYE 5BR8I 4JI3I 2C38B 2O3ZA 4DV7E 3P3GA 1J5EE 4MU4A 4DR2E 4LFBE 4JI1E 4MDTA 1H7SA 4DUYI 1YHCA 1B63A 5K36F 5JEAA 1UDNA 2A2CA 4JI4E 4Z7YA 4JI8I 1RR9A 1UDQA 1N33I 1R6MA 2UXCI 4DV5I 4Z7CA 4MU0A 2J7KA 3D4JA 1H7UA 4PRVA 4JI2E 1RHYA 1Z0VA 4X65I 4DV6E 1RREA 2BR2A 4USKA 3NZKA 4IFDD 1IBMI 2NN6E 4JI5I 1OYSA 2EFGA 5FLXC 4DV3E 2F4VI 1Z0CA 4JI7I 4LFCE 3P76A 2ZITA 1FNMA 4LFAI 1HNXI 2Z5EA 4AIMA 1HNXE 4U3DA 4WUDA 1MU5A 4HXZA 4HY1A 3J80Q 4GQUA 4U3BA 2HFUA 2F4VE 1XXEA 3V2UC 3WU6A 4JI5E 3J7AG 3U1YA 2JEBB 2UXCE 4OKGA 1U2RA 1ZXNA 2OI2A 2BM0A 1N33E 1NHJA 2PO0B 2HFSA 2BA1G 4FW3A 2JE6B 4LF7I 2GS8A 2BV3A 2X36A 4DR2I 2HKEA 3QT6A 4LF8I 1OYPA 4B3MI 4B3RE 5K36A 1HNWI 1S16A 4LPFA 2CG9A 3T1YE 1PIEA 5C0XB 5GMEA 3M6AA 4X66I 4EMDA 1OYRA 2VF3A 3LTOA 4DU7A 5K36E 4HACB 3GMEA 3H1CA 4DR1I 2WNRB 5BR8E 2PO1B 4NXMI 4ISAA 4DV0I 2NN6C 4P52A 3K17A 1R6LA 4OO1A 2UUBE 3T1HE 2PNZB 4AQYI 4JI0E 5K36C 2V2QA 1FI4A 3PS1A 4LF6E 2UUAE 1I94E 2Z5BA 2V2VA 4FW6A 4X66E 2Z5CA 2DEIA 5IT9Q 3HKMA 5DROA 3T1YI 2V8PA 2CVEA 2V34A 2PO1A 5A2QQ 1P42A 5LMUE 1H73A 2O1VA 2UUCE 1EI1A 4X64E 1BKNA 5LMUI 4FN5A 2IESA 1Z0WA 4IFDF 5K36B 3PYFA 4FWHA 1N36E 4OO1B 1N32I 2GO4A 4LCFA 4YHHE 5DNLA 2JE6A 1N34E 1XMOE 4M1KA 4IZJA 4PU9A 2IERA 3CWVA 1IBKE 2UU9E 2UUBI 4DR3E 4KQVA 2BA1D 2J65A 4DV4I 3LPSA 1XNQE 3ZZTA 1IBME 5IWAI 1Z5CA 2ZM6I 3PS2A 4NXNI 1IBLI 4BA2A 3J7AM 4ZVIA 2PNMA 2LJPA 3U1KA 2Q2EB 4DUZE 3QT5A 2XEXA 1ZM3A 3V5RA 5EKWA 2E5LE 5C0XD 4LF4E 4FWDA 1PVGA 5LMNI 3PYDA 1ELOA 2PNLA 3OTOI 4DR6E 1HNWE 4DV7I 4B3RI 4GKJE 4LF5I 2V2ZA 3UHMA 1FWLA 1NHHA 2WNRA 2Z5CB 1UEKA 4MU3A 1HK7A 4IFDE 4X62E 3PYGA 5A2QC 3ZKDA 3JAMC 4JYAI 4DR4I 2JT2A 3M7NG 4KHPE 3J81C 1Z0TA 1IBLE 1FKAE 4DPTA 4JI6E 4YY3E 3F0NA 4DR5I 5DRQA 5IWAE 5EL9A 2CZ9A 2WP8A 1E3PA 1XNQI 2HKJA 5IT9C 1VISA 4LFAE 2IOPA 3KRNA 1NZ0A 4DR3I 1Z59A 1HR0I 1UDOA 3B8HA 2UXBI 2O1TA 4LF9E 3WU3A 4HYMA 4USMA 4OO1E 4RPFA 2NPFA 1UDSA 1OJ4A 4MQYA 2UUCI 1N36I 4JYAE 1N0UA 2F1DA 2JEAB 4I3HA 3J80C 3B78A 4OZEA 4DV1E 3ZM7A 4DV2I 2VQFI 4LFBI 3H4LA 3JAMQ 3GLLA 4BA1B 1Z5AA 2O1WA 4DR6I 4LF9I 4XTJA 2C37B 1MX0A 4J3DA 4AIDA 4B3SI 1Z0GA 4QNJA 1KKHA 1Z0BA 2NN6A 3Q6NA 1USVA 3GONA 5DRPA 4HACA 4JI0I 4B3TE 4JV5I 4OO1D 2AJ4A 4KHPI 4NXME 4MU1A 3HULA 2C39B 5JEAF 4DR4E 4OO1C 4P7AA 1XNRI 1KTVA 4UTGA 2GO3A 4NBQA 4DR1E 3WU4A 4B3ME 1Y6ZA 4LF8E 2O1UA 1H74A 4FW7A 1USUA 2CGEA 5C0XC 1B62A 3PYEA 4LF4I 4DV1I 5ELWA 4URLA 4OX9I
chains in the Genus database with same CATH topology
3P3EA 3UHMA 4U3DA 2IESA 3PS2A 4LCGA 4U3BA 3PS1A 3PS3A 2GO3A 1XXEA 4J3DA 4MDTA 1YH8A 4FW4A 3U1YA 2VESA 4OKGA 2GO4A 4FW6A 4LCFA 4MQYA 2JT2A 5DRRA 5DRPA 4ISAA 5DROA 3NZKA 2IERA 4FW7A 5DRQA 4FW3A 4FW5A 2O3ZA 4OZEA 1P42A 2J65A 3P3GA 3P76A 4LCHA 4IS9A 3P3CA 1YHCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P3E A;  3UHM A;  4U3D A;  2IES A;  3PS2 A;  4LCG A;  4U3B A;  3PS1 A;  3PS3 A;  2GO3 A;  1XXE A;  4J3D A;  4MDT A;  1YH8 A;  4FW4 A;  3U1Y A;  2VES A;  4OKG A;  2GO4 A;  4FW6 A;  4LCF A;  4MQY A;  2JT2 A;  5DRR A;  5DRP A;  4ISA A;  5DRO A;  3NZK A;  2IER A;  4FW7 A;  5DRQ A;  4FW3 A;  4FW5 A;  2O3Z A;  4OZE A;  1P42 A;  2J65 A;  3P3G A;  3P76 A;  4LCH A;  4IS9 A;  3P3C A;  1YHC A; 
#chains in the Genus database with same CATH topology
 4LF7 E;  2VQF E;  5C0X F;  4K0K I;  4ED4 A;  5DNX A;  4DPW A;  4DV2 E;  4FW9 A;  2HK3 A;  1ZM2 A;  4DXL A;  2C38 A;  4WUB A;  3ZZ0 A;  1I94 I;  5K36 D;  1PKP A;  1IBK I;  2UU9 I;  2C39 A;  1XHK A;  1D6T A;  5JEA B;  2HK2 A;  3HJC A;  3LNU A;  4R1F A;  2PO0 A;  4LCH A;  2UXB E;  4N3O A;  1FWK A;  4JI2 I;  1N0V C;  4JI6 I;  4IFD C;  4DPX A;  4DV0 E;  4JG4 A;  3PRY A;  4MYT A;  3P06 A;  1Z5B A;  2NN6 B;  1NHI A;  3K1J A;  5C0X A;  2BA0 D;  3K85 A;  4YY3 I;  4DR5 E;  4JI4 I;  1Y60 A;  2VES A;  3ZZU A;  4X64 I;  1H72 C;  5DRR A;  4JI1 I;  4DV5 E;  1ZM9 A;  4QNK A;  4OX9 E;  4X62 I;  4FW5 A;  4BA1 A;  1K47 A;  2GQ0 A;  4BA2 B;  4LF5 E;  4GKJ I;  1FJG I;  4IFD B;  4FWG A;  2PO2 B;  4LF6 I;  1Y5Y A;  3OTO E;  4DPY A;  3PS3 A;  3M85 D;  4JI3 E;  5LMN E;  2DEJ A;  4AQY E;  1KIJ A;  1YH8 A;  4FW4 A;  2R42 A;  3L7Z A;  3QT8 A;  1XNR E;  3Q1Q A;  5FWK A;  4WUC A;  2E5L I;  1ZM4 A;  1XMQ E;  1ZXM A;  2ZM6 E;  2WP8 B;  4DUZ I;  2NN6 D;  4MYU A;  2AE8 A;  1Y4U A;  4JV5 E;  4NXN E;  4DV4 E;  4B3T I;  3M7N D;  2PNZ A;  4UT4 A;  3ZKB A;  3P3C A;  1QZR A;  1XMO I;  2VQE E;  1MG7 A;  4IZK B;  4LCG A;  4YHH I;  3CDI A;  4LFC I;  4JI7 E;  1S4E A;  3WU5 A;  1N32 E;  4DR7 I;  4DV3 I;  2HHH I;  1A6F A;  5FLX Q;  4IZJ D;  3DD6 A;  1N34 I;  4X65 E;  3Q6M A;  4PRX A;  1EA6 A;  2Z5B B;  2E1R A;  2IOQ A;  3CDJ A;  4K0K E;  3M85 G;  3GCM A;  2UXD I;  5GMD A;  4IFD A;  2R3V A;  4JI8 E;  5LL6 R;  4IS9 A;  2UXD E;  5C0X E;  3QT7 A;  3P3E A;  4DR7 E;  4AM3 A;  1Y4S A;  4LOM A;  1J5E I;  5JEA D;  2BM1 A;  3J81 Q;  2UUA I;  2JEA A;  1WUU A;  3B4T A;  1HR0 E;  2HHH E;  4DPU A;  3T1H I;  1KVK A;  1VI7 A;  4GKK I;  3L7Z B;  5L3J A;  2JEB A;  2VQE I;  4IZJ B;  1HNZ E;  4DV6 I;  2X7I A;  5JEA C;  4OO1 F;  2PO2 A;  2ZBK B;  2C37 A;  4DU8 A;  5JEA E;  1E3H A;  2A2D A;  1HNZ I;  1XMQ I;  2WW4 A;  3B82 A;  4IZK A;  1Z0E A;  1FJG E;  1DAR A;  2BR2 B;  2BA0 G;  2NN6 F;  4GKK E;  4B3S E;  4DUY E;  5BR8 I;  4JI3 I;  2C38 B;  2O3Z A;  4DV7 E;  3P3G A;  1J5E E;  4MU4 A;  4DR2 E;  4LFB E;  4JI1 E;  4MDT A;  1H7S A;  4DUY I;  1YHC A;  1B63 A;  5K36 F;  5JEA A;  1UDN A;  2A2C A;  4JI4 E;  4Z7Y A;  4JI8 I;  1RR9 A;  1UDQ A;  1N33 I;  1R6M A;  2UXC I;  4DV5 I;  4Z7C A;  4MU0 A;  2J7K A;  3D4J A;  1H7U A;  4PRV A;  4JI2 E;  1RHY A;  1Z0V A;  4X65 I;  4DV6 E;  1RRE A;  2BR2 A;  4USK A;  3NZK A;  4IFD D;  1IBM I;  2NN6 E;  4JI5 I;  1OYS A;  2EFG A;  5FLX C;  4DV3 E;  2F4V I;  1Z0C A;  4JI7 I;  4LFC E;  3P76 A;  2ZIT A;  1FNM A;  4LFA I;  1HNX I;  2Z5E A;  4AIM A;  1HNX E;  4U3D A;  4WUD A;  1MU5 A;  4HXZ A;  4HY1 A;  3J80 Q;  4GQU A;  4U3B A;  2HFU A;  2F4V E;  1XXE A;  3V2U C;  3WU6 A;  4JI5 E;  3J7A G;  3U1Y A;  2JEB B;  2UXC E;  4OKG A;  1U2R A;  1ZXN A;  2OI2 A;  2BM0 A;  1N33 E;  1NHJ A;  2PO0 B;  2HFS A;  2BA1 G;  4FW3 A;  2JE6 B;  4LF7 I;  2GS8 A;  2BV3 A;  2X36 A;  4DR2 I;  2HKE A;  3QT6 A;  4LF8 I;  1OYP A;  4B3M I;  4B3R E;  5K36 A;  1HNW I;  1S16 A;  4LPF A;  2CG9 A;  3T1Y E;  1PIE A;  5C0X B;  5GME A;  3M6A A;  4X66 I;  4EMD A;  1OYR A;  2VF3 A;  3LTO A;  4DU7 A;  5K36 E;  4HAC B;  3GME A;  3H1C A;  4DR1 I;  2WNR B;  5BR8 E;  2PO1 B;  4NXM I;  4ISA A;  4DV0 I;  2NN6 C;  4P52 A;  3K17 A;  1R6L A;  4OO1 A;  2UUB E;  3T1H E;  2PNZ B;  4AQY I;  4JI0 E;  5K36 C;  2V2Q A;  1FI4 A;  3PS1 A;  4LF6 E;  2UUA E;  1I94 E;  2Z5B A;  2V2V A;  4FW6 A;  4X66 E;  2Z5C A;  2DEI A;  5IT9 Q;  3HKM A;  5DRO A;  3T1Y I;  2V8P A;  2CVE A;  2V34 A;  2PO1 A;  5A2Q Q;  1P42 A;  5LMU E;  1H73 A;  2O1V A;  2UUC E;  1EI1 A;  4X64 E;  1BKN A;  5LMU I;  4FN5 A;  2IES A;  1Z0W A;  4IFD F;  5K36 B;  3PYF A;  4FWH A;  1N36 E;  4OO1 B;  1N32 I;  2GO4 A;  4LCF A;  4YHH E;  5DNL A;  2JE6 A;  1N34 E;  1XMO E;  4M1K A;  4IZJ A;  4PU9 A;  2IER A;  3CWV A;  1IBK E;  2UU9 E;  2UUB I;  4DR3 E;  4KQV A;  2BA1 D;  2J65 A;  4DV4 I;  3LPS A;  1XNQ E;  3ZZT A;  1IBM E;  5IWA I;  1Z5C A;  2ZM6 I;  3PS2 A;  4NXN I;  1IBL I;  4BA2 A;  3J7A M;  4ZVI A;  2PNM A;  2LJP A;  3U1K A;  2Q2E B;  4DUZ E;  3QT5 A;  2XEX A;  1ZM3 A;  3V5R A;  5EKW A;  2E5L E;  5C0X D;  4LF4 E;  4FWD A;  1PVG A;  5LMN I;  3PYD A;  1ELO A;  2PNL A;  3OTO I;  4DR6 E;  1HNW E;  4DV7 I;  4B3R I;  4GKJ E;  4LF5 I;  2V2Z A;  3UHM A;  1FWL A;  1NHH A;  2WNR A;  2Z5C B;  1UEK A;  4MU3 A;  1HK7 A;  4IFD E;  4X62 E;  3PYG A;  5A2Q C;  3ZKD A;  3JAM C;  4JYA I;  4DR4 I;  2JT2 A;  3M7N G;  4KHP E;  3J81 C;  1Z0T A;  1IBL E;  1FKA E;  4DPT A;  4JI6 E;  4YY3 E;  3F0N A;  4DR5 I;  5DRQ A;  5IWA E;  5EL9 A;  2CZ9 A;  2WP8 A;  1E3P A;  1XNQ I;  2HKJ A;  5IT9 C;  1VIS A;  4LFA E;  2IOP A;  3KRN A;  1NZ0 A;  4DR3 I;  1Z59 A;  1HR0 I;  1UDO A;  3B8H A;  2UXB I;  2O1T A;  4LF9 E;  3WU3 A;  4HYM A;  4USM A;  4OO1 E;  4RPF A;  2NPF A;  1UDS A;  1OJ4 A;  4MQY A;  2UUC I;  1N36 I;  4JYA E;  1N0U A;  2F1D A;  2JEA B;  4I3H A;  3J80 C;  3B78 A;  4OZE A;  4DV1 E;  3ZM7 A;  4DV2 I;  2VQF I;  4LFB I;  3H4L A;  3JAM Q;  3GLL A;  4BA1 B;  1Z5A A;  2O1W A;  4DR6 I;  4LF9 I;  4XTJ A;  2C37 B;  1MX0 A;  4J3D A;  4AID A;  4B3S I;  1Z0G A;  4QNJ A;  1KKH A;  1Z0B A;  2NN6 A;  3Q6N A;  1USV A;  3GON A;  5DRP A;  4HAC A;  4JI0 I;  4B3T E;  4JV5 I;  4OO1 D;  2AJ4 A;  4KHP I;  4NXM E;  4MU1 A;  3HUL A;  2C39 B;  5JEA F;  4DR4 E;  4OO1 C;  4P7A A;  1XNR I;  1KTV A;  4UTG A;  2GO3 A;  4NBQ A;  4DR1 E;  3WU4 A;  4B3M E;  1Y6Z A;  4LF8 E;  2O1U A;  1H74 A;  4FW7 A;  1USU A;  2CGE A;  5C0X C;  1B62 A;  3PYE A;  4LF4 I;  4DV1 I;  5ELW A;  4URL A;  4OX9 I; 
#chains in the Genus database with same CATH homology
 3P3E A;  3UHM A;  4U3D A;  2IES A;  3PS2 A;  4LCG A;  4U3B A;  3PS1 A;  3PS3 A;  2GO3 A;  1XXE A;  4J3D A;  4MDT A;  1YH8 A;  4FW4 A;  3U1Y A;  2VES A;  4OKG A;  2GO4 A;  4FW6 A;  4LCF A;  4MQY A;  2JT2 A;  5DRR A;  5DRP A;  4ISA A;  5DRO A;  3NZK A;  2IER A;  4FW7 A;  5DRQ A;  4FW3 A;  4FW5 A;  2O3Z A;  4OZE A;  1P42 A;  2J65 A;  3P3G A;  3P76 A;  4LCH A;  4IS9 A;  3P3C A;  1YHC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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