3P3GA

Crystal structure of the escherichia coli lpxc/lpc-009 complex
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
pubmed doi rcsb
source organism Escherichia coli
total genus 85
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2010-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3p3gA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3p3gA02
3P76A 2IERA 2JT2A 4J3DA 4ISAA 5DRQA 2GO3A 5DRPA 2J65A 2IESA 3P3EA 4FW3A 4LCGA 2GO4A 4MQYA 1P42A 4OZEA 1YHCA 4FW4A 3PS3A 2VESA 4FW7A 3UHMA 5DRRA 3PS2A 4FW6A 4MDTA 4U3DA 4U3BA 4OKGA 5DROA 4LCFA 3P3GA 3P3CA 1XXEA 4FW5A 3NZKA 2O3ZA 4IS9A 3PS1A 3U1YA 1YH8A 4LCHA
chains in the Genus database with same CATH superfamily
3U1KA 2NPFA 4JI3I 2PO0B 4OO1F 4OO1A 4MYTA 3F0NA 3ZZUA 1Z5BA 4LF4I 4LF6I 1Z0TA 2HFSA 3KRNA 2HHHI 1B62A 1IBME 3WU5A 2JE6A 2AJ4A 4LF9E 2WW4A 2O1WA 4MYUA 4OKGA 3P3CA 5FLXC 4MU1A 3NZKA 2PO1B 2UXBI 1N32I 4HACB 4AIDA 2NN6F 3B82A 4PU9A 2VQFI 3T1YI 4IFDB 4OO1D 2NN6A 4PRVA 1WUUA 5JEAF 2JEAB 5JEAA 2UXCI 3V2UC 3JAMQ 4DV7E 2R42A 4AIMA 3K1JA 2HKEA 4IFDC 1NZ0A 1Y4SA 2BA1D 4NXNI 1ZXNA 4YHHE 5K36E 4Z7CA 5C0XE 1HNXI 4DR5I 4JYAE 4LFAE 2HFUA 1UDNA 2PNZA 4FN5A 3J7AG 1UEKA 1N36I 1H7UA 4DR6I 4JV5I 4GKJI 2JEBA 4YY3I 2UU9E 3ZZTA 2UUCI 3T1HE 1H74A 4DV0E 4IZKB 5K36C 1UDOA 3DD6A 4X62I 2UXDI 4JI8I 1FI4A 1FJGI 2VESA 4FW7A 4DUYE 2VQEE 2C38B 4MDTA 1XNRE 2E5LE 4USKA 1N34I 4JI3E 4B3SI 3J7AM 4UT4A 1Z0VA 2C39B 1XNQI 1H73A 4BA2B 4DR2E 2BR2A 1IBLI 5ELWA 4DPXA 5DNLA 4DV5I 1OJ4A 4OO1E 2JEAA 5DRRA 3J80Q 1FWKA 3J81C 2Z5EA 4LF7E 1J5EE 2DEIA 4LCFA 4I3HA 2UXCE 4IS9A 3PYEA 5A2QQ 3M85G 1XMQI 3K85A 4DV3I 1DARA 3HULA 4NXNE 4FW3A 4IZJA 4X66I 4OZEA 5GMDA 3PS3A 4DUZI 1N36E 4QNKA 3WU4A 2Z5CA 3M6AA 4DV4I 4JV5E 3CDIA 4GKJE 4LFBI 3B8HA 1S16A 4B3TE 4NBQA 4DV1E 1I94E 3L7ZB 3U1YA 2ZITA 4IZJD 2HKJA 2C38A 1IBKI 4JI1I 5DRQA 3OTOI 2C37B 1KTVA 3GONA 4MQYA 2BA0G 5IWAI 1PIEA 1ZM2A 3Q6MA 4JI4E 3V5RA 2C39A 1HNZI 2IOPA 2WP8B 2V34A 5LMUE 4GKKI 3H1CA 4DR3I 3LNUA 1OYSA 4FWHA 4FWGA 1H7SA 1A6FA 2O1UA 2F4VE 4DV5E 3HJCA 1N33I 2HK3A 2JT2A 4DR1E 1ZM9A 4BA1A 4B3MI 3LPSA 2V2QA 1XHKA 2J7KA 4JI2E 2PNMA 4DR4I 2V2VA 2WNRB 4JI0I 4AQYE 4B3RI 1HK7A 2R3VA 1KVKA 2NN6D 4LF8E 5K36B 5JEAD 4JI6E 5C0XB 5DNXA 4DPUA 1UDSA 3CDJA 4OX9E 2VF3A 1S4EA 1YH8A 2OI2A 4DV2I 4LFCE 1H72C 3QT8A 3H4LA 1R6LA 1Y60A 5IT9Q 3P3EA 5C0XC 3ZM7A 4JI7I 1NHJA 5LL6R 4Z7YA 4LFBE 1USVA 4MU0A 1PKPA 1Z5CA 4X65I 2UUBE 1XMOE 2PO0A 2C37A 4U3BA 1NHHA 5DROA 4NXMI 1USUA 2CZ9A 1D6TA 3PYGA 3P06A 2O3ZA 1IBKE 3JAMC 4KHPI 5EKWA 2ZBKB 3GMEA 5IWAE 2IERA 4JI5I 4LF4E 4LF6E 1E3HA 1HR0I 2V2ZA 2IESA 2HHHE 2GO4A 1P42A 5LMNI 2PO1A 3M7NG 1Z5AA 4HACA 4IFDF 4AM3A 4DU8A 1ZXMA 4DR3E 4IFDA 1R6MA 1ZM3A 2Q2EB 2UXBE 1N32E 4LF5I 4OO1B 2VQFE 3WU3A 3T1YE 3LTOA 5GMEA 4ZVIA 4XTJA 4UTGA 1MU5A 4LF9I 4KQVA 2WNRA 1N0VC 1FKAE 3HKMA 4DU7A 4FW9A 4OO1C 2GO3A 4JG4A 4IFDD 2BM1A 2NN6E 5K36F 4DR7I 4JI0E 4MU3A 5JEAE 3PYFA 5K36A 4DV7I 1HNXE 4N3OA 4DR5E 4GQUA 4FW4A 1Z0GA 5EL9A 1B63A 4DV6I 4K0KI 1EI1A 4DR6E 2X36A 4U3DA 4YHHI 4IZKA 1K47A 4YY3E 3P3GA 2DEJA 2UUCE 4ED4A 4JYAI 4LFAI 4URLA 2NN6C 5FLXQ 5JEAC 3QT6A 2BM0A 4X62E 4JI7E 2UUAI 2UXDE 5DRPA 2UU9I 3QT5A 4JI8E 1FJGE 3T1HI 4X65E 2GS8A 2O1TA 1ZM4A 2Z5BB 4WUCA 3J80C 4DV0I 2JEBB 4LOMA 3ZZ0A 1VISA 1ELOA 1Z59A 4M1KA 2ZM6I 2BA1G 4BA2A 2PO2B 1N34E 4FW6A 4B3SE 5A2QC 2V8PA 1XNQE 4DUYI 2VQEI 3M85D 1XNRI 2E5LI 4DPWA 1HNWI 1IBLE 1VI7A 5LMNE 2X7IA 1U2RA 5FWKA 4DR2I 4P52A 3D4JA 1MG7A 4LF5E 1FNMA 1PVGA 1Z0CA 1Z0WA 3QT7A 2BR2B 3WU6A 4IFDE 1N0UA 1XMQE 4LF7I 1J5EI 4DV3E 1BKNA 4DR7E 4ISAA 3B78A 4P7AA 4X66E 2BA0D 3K17A 2IOQA 4HXZA 4DUZE 4DV6E 4K0KE 4USMA 4DV4E 4HYMA 3L7ZA 4DPTA 3PS2A 5BR8I 4RPFA 4DPYA 4WUBA 4IZJB 1XXEA 1RHYA 4X64I 3J81Q 2Z5BA 1Y4UA 2A2DA 2UUAE 2HK2A 3CWVA 4MU4A 4JI1E 3OTOE 4LCHA 2Z5CB 2WP8A 4B3TI 2PO2A 4DV1I 3Q1QA 1I94I 4DXLA 4EMDA 1OYRA 1HNZE 2ZM6E 5L3JA 4GKKE 4LPFA 2E1RA 2EFGA 4JI4I 3GCMA 3Q6NA 1HNWE 2PNLA 1IBMI 4FW5A 1EA6A 5LMUI 4FWDA 4R1FA 1N33E 3PRYA 4B3ME 5IT9C 2CG9A 2JE6B 4PRXA 2AE8A 4J3DA 1Z0BA 1OYPA 2F4VI 4DR4E 4B3RE 5C0XF 4DR1I 5C0XA 1YHCA 2LJPA 2CGEA 2NN6B 3UHMA 5JEAB 4JI2I 3PYDA 3B4TA 1RR9A 1KKHA 4BA1B 1QZRA 1RREA 1Z0EA 4AQYI 3ZKBA 4DV2E 2F1DA 1NHIA 2XEXA 4LF8I 3P76A 2GQ0A 4JI6I 5K36D 5C0XD 4QNJA 4OX9I 2J65A 3M7ND 4LCGA 4LFCI 2PNZB 5BR8E 2O1VA 3ZKDA 2A2CA 4WUDA 1MX0A 4X64E 4NXME 3GLLA 1E3PA 1Y5YA 2BV3A 2CVEA 1Y6ZA 1KIJA 4KHPE 4HY1A 2UUBI 1XMOI 3PS1A 1FWLA 4JI5E 1HR0E 1UDQA
chains in the Genus database with same CATH topology
3P76A 2IERA 2JT2A 4J3DA 4ISAA 5DRQA 2GO3A 5DRPA 2J65A 2IESA 3P3EA 4FW3A 4LCGA 2GO4A 4MQYA 1P42A 4OZEA 1YHCA 4FW4A 3PS3A 2VESA 4FW7A 3UHMA 5DRRA 3PS2A 4FW6A 4MDTA 4U3DA 4U3BA 4OKGA 5DROA 4LCFA 3P3GA 3P3CA 1XXEA 4FW5A 3NZKA 2O3ZA 4IS9A 3PS1A 3U1YA 1YH8A 4LCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P76 A;  2IER A;  2JT2 A;  4J3D A;  4ISA A;  5DRQ A;  2GO3 A;  5DRP A;  2J65 A;  2IES A;  3P3E A;  4FW3 A;  4LCG A;  2GO4 A;  4MQY A;  1P42 A;  4OZE A;  1YHC A;  4FW4 A;  3PS3 A;  2VES A;  4FW7 A;  3UHM A;  5DRR A;  3PS2 A;  4FW6 A;  4MDT A;  4U3D A;  4U3B A;  4OKG A;  5DRO A;  4LCF A;  3P3G A;  3P3C A;  1XXE A;  4FW5 A;  3NZK A;  2O3Z A;  4IS9 A;  3PS1 A;  3U1Y A;  1YH8 A;  4LCH A; 
#chains in the Genus database with same CATH topology
 3U1K A;  2NPF A;  4JI3 I;  2PO0 B;  4OO1 F;  4OO1 A;  4MYT A;  3F0N A;  3ZZU A;  1Z5B A;  4LF4 I;  4LF6 I;  1Z0T A;  2HFS A;  3KRN A;  2HHH I;  1B62 A;  1IBM E;  3WU5 A;  2JE6 A;  2AJ4 A;  4LF9 E;  2WW4 A;  2O1W A;  4MYU A;  4OKG A;  3P3C A;  5FLX C;  4MU1 A;  3NZK A;  2PO1 B;  2UXB I;  1N32 I;  4HAC B;  4AID A;  2NN6 F;  3B82 A;  4PU9 A;  2VQF I;  3T1Y I;  4IFD B;  4OO1 D;  2NN6 A;  4PRV A;  1WUU A;  5JEA F;  2JEA B;  5JEA A;  2UXC I;  3V2U C;  3JAM Q;  4DV7 E;  2R42 A;  4AIM A;  3K1J A;  2HKE A;  4IFD C;  1NZ0 A;  1Y4S A;  2BA1 D;  4NXN I;  1ZXN A;  4YHH E;  5K36 E;  4Z7C A;  5C0X E;  1HNX I;  4DR5 I;  4JYA E;  4LFA E;  2HFU A;  1UDN A;  2PNZ A;  4FN5 A;  3J7A G;  1UEK A;  1N36 I;  1H7U A;  4DR6 I;  4JV5 I;  4GKJ I;  2JEB A;  4YY3 I;  2UU9 E;  3ZZT A;  2UUC I;  3T1H E;  1H74 A;  4DV0 E;  4IZK B;  5K36 C;  1UDO A;  3DD6 A;  4X62 I;  2UXD I;  4JI8 I;  1FI4 A;  1FJG I;  2VES A;  4FW7 A;  4DUY E;  2VQE E;  2C38 B;  4MDT A;  1XNR E;  2E5L E;  4USK A;  1N34 I;  4JI3 E;  4B3S I;  3J7A M;  4UT4 A;  1Z0V A;  2C39 B;  1XNQ I;  1H73 A;  4BA2 B;  4DR2 E;  2BR2 A;  1IBL I;  5ELW A;  4DPX A;  5DNL A;  4DV5 I;  1OJ4 A;  4OO1 E;  2JEA A;  5DRR A;  3J80 Q;  1FWK A;  3J81 C;  2Z5E A;  4LF7 E;  1J5E E;  2DEI A;  4LCF A;  4I3H A;  2UXC E;  4IS9 A;  3PYE A;  5A2Q Q;  3M85 G;  1XMQ I;  3K85 A;  4DV3 I;  1DAR A;  3HUL A;  4NXN E;  4FW3 A;  4IZJ A;  4X66 I;  4OZE A;  5GMD A;  3PS3 A;  4DUZ I;  1N36 E;  4QNK A;  3WU4 A;  2Z5C A;  3M6A A;  4DV4 I;  4JV5 E;  3CDI A;  4GKJ E;  4LFB I;  3B8H A;  1S16 A;  4B3T E;  4NBQ A;  4DV1 E;  1I94 E;  3L7Z B;  3U1Y A;  2ZIT A;  4IZJ D;  2HKJ A;  2C38 A;  1IBK I;  4JI1 I;  5DRQ A;  3OTO I;  2C37 B;  1KTV A;  3GON A;  4MQY A;  2BA0 G;  5IWA I;  1PIE A;  1ZM2 A;  3Q6M A;  4JI4 E;  3V5R A;  2C39 A;  1HNZ I;  2IOP A;  2WP8 B;  2V34 A;  5LMU E;  4GKK I;  3H1C A;  4DR3 I;  3LNU A;  1OYS A;  4FWH A;  4FWG A;  1H7S A;  1A6F A;  2O1U A;  2F4V E;  4DV5 E;  3HJC A;  1N33 I;  2HK3 A;  2JT2 A;  4DR1 E;  1ZM9 A;  4BA1 A;  4B3M I;  3LPS A;  2V2Q A;  1XHK A;  2J7K A;  4JI2 E;  2PNM A;  4DR4 I;  2V2V A;  2WNR B;  4JI0 I;  4AQY E;  4B3R I;  1HK7 A;  2R3V A;  1KVK A;  2NN6 D;  4LF8 E;  5K36 B;  5JEA D;  4JI6 E;  5C0X B;  5DNX A;  4DPU A;  1UDS A;  3CDJ A;  4OX9 E;  2VF3 A;  1S4E A;  1YH8 A;  2OI2 A;  4DV2 I;  4LFC E;  1H72 C;  3QT8 A;  3H4L A;  1R6L A;  1Y60 A;  5IT9 Q;  3P3E A;  5C0X C;  3ZM7 A;  4JI7 I;  1NHJ A;  5LL6 R;  4Z7Y A;  4LFB E;  1USV A;  4MU0 A;  1PKP A;  1Z5C A;  4X65 I;  2UUB E;  1XMO E;  2PO0 A;  2C37 A;  4U3B A;  1NHH A;  5DRO A;  4NXM I;  1USU A;  2CZ9 A;  1D6T A;  3PYG A;  3P06 A;  2O3Z A;  1IBK E;  3JAM C;  4KHP I;  5EKW A;  2ZBK B;  3GME A;  5IWA E;  2IER A;  4JI5 I;  4LF4 E;  4LF6 E;  1E3H A;  1HR0 I;  2V2Z A;  2IES A;  2HHH E;  2GO4 A;  1P42 A;  5LMN I;  2PO1 A;  3M7N G;  1Z5A A;  4HAC A;  4IFD F;  4AM3 A;  4DU8 A;  1ZXM A;  4DR3 E;  4IFD A;  1R6M A;  1ZM3 A;  2Q2E B;  2UXB E;  1N32 E;  4LF5 I;  4OO1 B;  2VQF E;  3WU3 A;  3T1Y E;  3LTO A;  5GME A;  4ZVI A;  4XTJ A;  4UTG A;  1MU5 A;  4LF9 I;  4KQV A;  2WNR A;  1N0V C;  1FKA E;  3HKM A;  4DU7 A;  4FW9 A;  4OO1 C;  2GO3 A;  4JG4 A;  4IFD D;  2BM1 A;  2NN6 E;  5K36 F;  4DR7 I;  4JI0 E;  4MU3 A;  5JEA E;  3PYF A;  5K36 A;  4DV7 I;  1HNX E;  4N3O A;  4DR5 E;  4GQU A;  4FW4 A;  1Z0G A;  5EL9 A;  1B63 A;  4DV6 I;  4K0K I;  1EI1 A;  4DR6 E;  2X36 A;  4U3D A;  4YHH I;  4IZK A;  1K47 A;  4YY3 E;  3P3G A;  2DEJ A;  2UUC E;  4ED4 A;  4JYA I;  4LFA I;  4URL A;  2NN6 C;  5FLX Q;  5JEA C;  3QT6 A;  2BM0 A;  4X62 E;  4JI7 E;  2UUA I;  2UXD E;  5DRP A;  2UU9 I;  3QT5 A;  4JI8 E;  1FJG E;  3T1H I;  4X65 E;  2GS8 A;  2O1T A;  1ZM4 A;  2Z5B B;  4WUC A;  3J80 C;  4DV0 I;  2JEB B;  4LOM A;  3ZZ0 A;  1VIS A;  1ELO A;  1Z59 A;  4M1K A;  2ZM6 I;  2BA1 G;  4BA2 A;  2PO2 B;  1N34 E;  4FW6 A;  4B3S E;  5A2Q C;  2V8P A;  1XNQ E;  4DUY I;  2VQE I;  3M85 D;  1XNR I;  2E5L I;  4DPW A;  1HNW I;  1IBL E;  1VI7 A;  5LMN E;  2X7I A;  1U2R A;  5FWK A;  4DR2 I;  4P52 A;  3D4J A;  1MG7 A;  4LF5 E;  1FNM A;  1PVG A;  1Z0C A;  1Z0W A;  3QT7 A;  2BR2 B;  3WU6 A;  4IFD E;  1N0U A;  1XMQ E;  4LF7 I;  1J5E I;  4DV3 E;  1BKN A;  4DR7 E;  4ISA A;  3B78 A;  4P7A A;  4X66 E;  2BA0 D;  3K17 A;  2IOQ A;  4HXZ A;  4DUZ E;  4DV6 E;  4K0K E;  4USM A;  4DV4 E;  4HYM A;  3L7Z A;  4DPT A;  3PS2 A;  5BR8 I;  4RPF A;  4DPY A;  4WUB A;  4IZJ B;  1XXE A;  1RHY A;  4X64 I;  3J81 Q;  2Z5B A;  1Y4U A;  2A2D A;  2UUA E;  2HK2 A;  3CWV A;  4MU4 A;  4JI1 E;  3OTO E;  4LCH A;  2Z5C B;  2WP8 A;  4B3T I;  2PO2 A;  4DV1 I;  3Q1Q A;  1I94 I;  4DXL A;  4EMD A;  1OYR A;  1HNZ E;  2ZM6 E;  5L3J A;  4GKK E;  4LPF A;  2E1R A;  2EFG A;  4JI4 I;  3GCM A;  3Q6N A;  1HNW E;  2PNL A;  1IBM I;  4FW5 A;  1EA6 A;  5LMU I;  4FWD A;  4R1F A;  1N33 E;  3PRY A;  4B3M E;  5IT9 C;  2CG9 A;  2JE6 B;  4PRX A;  2AE8 A;  4J3D A;  1Z0B A;  1OYP A;  2F4V I;  4DR4 E;  4B3R E;  5C0X F;  4DR1 I;  5C0X A;  1YHC A;  2LJP A;  2CGE A;  2NN6 B;  3UHM A;  5JEA B;  4JI2 I;  3PYD A;  3B4T A;  1RR9 A;  1KKH A;  4BA1 B;  1QZR A;  1RRE A;  1Z0E A;  4AQY I;  3ZKB A;  4DV2 E;  2F1D A;  1NHI A;  2XEX A;  4LF8 I;  3P76 A;  2GQ0 A;  4JI6 I;  5K36 D;  5C0X D;  4QNJ A;  4OX9 I;  2J65 A;  3M7N D;  4LCG A;  4LFC I;  2PNZ B;  5BR8 E;  2O1V A;  3ZKD A;  2A2C A;  4WUD A;  1MX0 A;  4X64 E;  4NXM E;  3GLL A;  1E3P A;  1Y5Y A;  2BV3 A;  2CVE A;  1Y6Z A;  1KIJ A;  4KHP E;  4HY1 A;  2UUB I;  1XMO I;  3PS1 A;  1FWL A;  4JI5 E;  1HR0 E;  1UDQ A; 
#chains in the Genus database with same CATH homology
 3P76 A;  2IER A;  2JT2 A;  4J3D A;  4ISA A;  5DRQ A;  2GO3 A;  5DRP A;  2J65 A;  2IES A;  3P3E A;  4FW3 A;  4LCG A;  2GO4 A;  4MQY A;  1P42 A;  4OZE A;  1YHC A;  4FW4 A;  3PS3 A;  2VES A;  4FW7 A;  3UHM A;  5DRR A;  3PS2 A;  4FW6 A;  4MDT A;  4U3D A;  4U3B A;  4OKG A;  5DRO A;  4LCF A;  3P3G A;  3P3C A;  1XXE A;  4FW5 A;  3NZK A;  2O3Z A;  4IS9 A;  3PS1 A;  3U1Y A;  1YH8 A;  4LCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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