3P3GA

Crystal structure of the escherichia coli lpxc/lpc-009 complex
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
publication title Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 85
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2010-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3p3gA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3p3gA02
2J65A 4FW7A 3PS3A 5DRQA 4OZEA 2JT2A 4FW6A 5DRRA 4MDTA 3U1YA 3UHMA 4U3BA 3P3GA 4LCGA 4ISAA 3P3EA 1YH8A 2VESA 2IERA 3PS2A 1XXEA 1YHCA 4J3DA 3NZKA 3PS1A 4LCFA 2GO4A 4MQYA 4FW4A 4OKGA 2O3ZA 1P42A 2GO3A 4LCHA 5DRPA 4FW3A 4FW5A 4IS9A 5DROA 4U3DA 3P3CA 3P76A 2IESA
chains in the Genus database with same CATH superfamily
4JYAI 4JV5E 1HNZI 4DV3E 2F4VE 4JI2E 4DU8A 4DR4I 4DR6I 1HNXI 4LFBI 3D4JA 3V2UC 1NZ0A 4AM3A 1XMOE 1N0UA 3GONA 3PS1A 4XTJA 4X64I 4FW4A 3J80Q 5LMUE 4FW9A 4DPXA 4X62I 4WUCA 3JAMC 4IFDA 2LJPA 2OI2A 3L7ZB 1IBME 3CDIA 4JI7I 3J7AM 1XMQI 4IFDF 4X66I 1I94E 1N34E 4OX9I 3V5RA 3ZZUA 4K0KE 3P76A 4USMA 2PO0B 2HK2A 4FWGA 4B3SI 4YY3I 2JT2A 1XHKA 5FLXC 2BR2B 3P3EA 1YH8A 3Q6MA 4X65E 4DV4I 1ZXNA 2PO1A 4OO1E 1Z0WA 2J7KA 3CWVA 4LFCI 1UDNA 2NN6E 2CVEA 4DXLA 3WU3A 5K36B 3HULA 1Y6ZA 2O1VA 2HKEA 4M1KA 4DV0E 4HYMA 2BA0G 4B3TE 4FW3A 5C0XC 3T1YI 5BR8I 1XNRI 1RREA 2JEBB 1ZXMA 3OTOE 1FJGI 2X7IA 1Z5AA 4MYTA 4JI4E 4HXZA 4U3BA 4DR5E 1Z0GA 1XXEA 1ELOA 4JG4A 1N33I 1S16A 2JEAB 1U2RA 1Z0BA 4YHHE 2UXDE 2C38B 3T1HE 2Z5CB 1B63A 2UXCE 1H7UA 5LMNE 5A2QC 2ZBKB 1NHIA 2C37A 3QT8A 5DRQA 2PNZA 4JI8E 2R3VA 1HR0E 4OO1A 4OZEA 2GQ0A 5LL6R 4DR1E 2UUAI 4LF7E 3UHMA 4ISAA 4GKJI 4OO1F 1OYRA 5LMUI 4JI6E 2NN6F 2AE8A 4KHPE 5JEAE 1S4EA 4AQYI 2A2DA 2V2QA 2IOQA 5IWAI 2UUCI 4LPFA 4HACB 2ZM6E 4DV6E 1Z5BA 3WU4A 4JI0I 2V2ZA 1NHJA 4BA2A 1PIEA 4DR3E 4URLA 3J80C 4LFAI 2HFSA 2HHHE 4LF6E 4NXNE 4LF8E 2C39A 1IBLE 3PYEA 1IBKE 3PYFA 4DV0I 2UXBI 1QZRA 4IS9A 4IZKB 5DROA 1Z0CA 4DUYE 2VF3A 2Q2EB 4DR7E 2WW4A 2BM0A 1H7SA 3LNUA 3U1YA 5JEAA 1ZM9A 4JI1E 4QNKA 2VESA 5K36D 4DR2E 4Z7YA 5JEAF 5ELWA 4IFDB 2E5LE 3M7ND 4FWDA 1P42A 2UXCI 4MU0A 3J81C 2V34A 2PNLA 1RR9A 2WNRA 2VQEI 4DR1I 4ZVIA 2JE6A 4Z7CA 4NBQA 1OJ4A 5EKWA 4HY1A 1H73A 2PO1B 4LCGA 4KHPI 1UDSA 1J5EE 3NZKA 4FN5A 3HJCA 2AJ4A 4B3ME 1FKAE 1ZM4A 2Z5EA 1XNQI 2X36A 3F0NA 3KRNA 4DU7A 3H4LA 2VQFE 1PKPA 2NN6D 3QT5A 1ZM2A 5DNLA 1Z0VA 3Q6NA 4MU3A 4DR3I 2HHHI 4LF6I 4NXME 5C0XA 1Z0EA 1UDOA 4DV1I 1IBKI 5C0XF 5K36C 1YHCA 2Z5BA 4J3DA 2GO4A 4DV2E 4DPYA 4MQYA 2IOPA 3CDJA 3M85G 2O3ZA 5GMDA 3GLLA 3PRYA 1H74A 2GS8A 2BA1G 1N32E 4IZJD 4B3RI 4DUYI 4DV7I 4DV6I 4FW5A 4JV5I 4JI3E 1HNWE 3B78A 2C37B 4LF9E 2PNZB 4DV3I 2IESA 3PYGA 4OO1B 2F4VI 4JI2I 1EI1A 2BM1A 3DD6A 2NN6B 3Q1QA 1WUUA 5DRRA 4DR2I 1XMOI 1HNZE 3ZM7A 1KTVA 4DR4E 2E5LI 4LCFA 4LFBE 4UTGA 4WUDA 4P52A 1IBMI 4X64E 3ZZ0A 1I94I 1N34I 4X62E 4K0KI 2NN6C 4JI7E 4R1FA 4LF4E 1XMQE 4FWHA 4X66E 4IZJB 1DARA 4BA2B 4OX9E 4BA1A 2CG9A 3B4TA 3P06A 4X65I 3GMEA 1N0VC 1PVGA 2O1WA 4MDTA 2C39B 3LPSA 4B3SE 4YY3E 4DV5E 4IFDD 1UEKA 2EFGA 1Y4UA 4P7AA 4DV4E 5IT9Q 4LFCE 2VQFI 2PNMA 2DEIA 4B3TI 1VISA 4MU1A 3ZZTA 4EMDA 1D6TA 1Z5CA 4U3DA 2O1TA 2BA0D 2WP8A 3OTOI 4JI4I 2DEJA 5BR8E 1XNRE 5JEAB 4DR5I 4LOMA 4MU4A 1FJGE 4ED4A 5A2QQ 4PRXA 4JI5E 1EA6A 4YHHI 5C0XE 1N36E 1N32I 4UT4A 4N3OA 1Y4SA 1N33E 2UXDI 1HK7A 4MYUA 3T1HI 4LCHA 3M85D 4LF5E 4LF9I 2WNRB 5LMNI 1K47A 4IZKA 4JI8I 2UU9E 2PO2A 1HR0I 5FWKA 4LF7I 5L3JA 3PS3A 1FNMA 4DPTA 4JI6I 4GKKE 2UUAE 4IFDC 2HFUA 4GKJE 1E3PA 1UDQA 1FWLA 2ZM6I 1KKHA 4AQYE 4GQUA 3QT7A 4LF4I 1BKNA 1Z59A 1MX0A 4OO1D 3B8HA 1NHHA 3L7ZA 5IWAE 3P3CA 2UUCE 1FI4A 4PU9A 5C0XB 4DV5I 4JI0E 2PO0A 4NXNI 4LF8I 3K85A 2Z5BB 3ZKBA 4WUBA 3ZKDA 1IBLI 1FWKA 5K36E 4LFAE 2BR2A 4USKA 4AIMA 1OYPA 2V2VA 5K36A 1R6LA 3K1JA 2UXBE 4DPUA 5K36F 2E1RA 3B82A 4DUZE 4DR7I 3JAMQ 3J81Q 2UUBE 2JEBA 1USUA 2HK3A 4JI1I 3T1YE 4JI5I 4JYAE 1USVA 5IT9C 2BV3A 1N36I 3PS2A 1MU5A 1KIJA 4DR6E 1HNXE 3M7NG 4LF5I 5FLXQ 1RHYA 1B62A 2JEAA 4DV7E 2A2CA 3M6AA 5DRPA 2UU9I 4OO1C 2CZ9A 4DPWA 3U1KA 5JEAD 1H72C 2C38A 4BA1B 2Z5CA 2J65A 4GKKI 2VQEE 1OYSA 3K17A 2NN6A 2ZITA 1J5EI 4B3MI 3H1CA 1Y5YA 2O1UA 2XEXA 3LTOA 1Z0TA 1ZM3A 2V8PA 3WU6A 1MG7A 4AIDA 2GO3A 5GMEA 1XNQE 2WP8B 4IFDE 1A6FA 4HACA 1Y60A 3PYDA 4QNJA 4FW7A 4NXMI 4IZJA 1VI7A 4FW6A 4PRVA 1KVKA 2F1DA 3P3GA 4KQVA 4DV2I 2IERA 3GCMA 5DNXA 4RPFA 4DV1E 1R6MA 4I3HA 4OKGA 3HKMA 2HKJA 3QT6A 2R42A 4DUZI 4JI3I 1HNWI 2CGEA 3J7AG 2BA1D 2PO2B 2NPFA 5C0XD 2UUBI 4B3RE 2JE6B 5JEAC 5EL9A 1E3HA 3WU5A
chains in the Genus database with same CATH topology
2J65A 4FW7A 3PS3A 5DRQA 4OZEA 2JT2A 4FW6A 5DRRA 4MDTA 3U1YA 3UHMA 4U3BA 3P3GA 4LCGA 4ISAA 3P3EA 1YH8A 2VESA 2IERA 3PS2A 1XXEA 1YHCA 4J3DA 3NZKA 3PS1A 4LCFA 2GO4A 4MQYA 4FW4A 4OKGA 2O3ZA 1P42A 2GO3A 4LCHA 5DRPA 4FW3A 4FW5A 4IS9A 5DROA 4U3DA 3P3CA 3P76A 2IESA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J65 A;  4FW7 A;  3PS3 A;  5DRQ A;  4OZE A;  2JT2 A;  4FW6 A;  5DRR A;  4MDT A;  3U1Y A;  3UHM A;  4U3B A;  3P3G A;  4LCG A;  4ISA A;  3P3E A;  1YH8 A;  2VES A;  2IER A;  3PS2 A;  1XXE A;  1YHC A;  4J3D A;  3NZK A;  3PS1 A;  4LCF A;  2GO4 A;  4MQY A;  4FW4 A;  4OKG A;  2O3Z A;  1P42 A;  2GO3 A;  4LCH A;  5DRP A;  4FW3 A;  4FW5 A;  4IS9 A;  5DRO A;  4U3D A;  3P3C A;  3P76 A;  2IES A; 
#chains in the Genus database with same CATH topology
 4JYA I;  4JV5 E;  1HNZ I;  4DV3 E;  2F4V E;  4JI2 E;  4DU8 A;  4DR4 I;  4DR6 I;  1HNX I;  4LFB I;  3D4J A;  3V2U C;  1NZ0 A;  4AM3 A;  1XMO E;  1N0U A;  3GON A;  3PS1 A;  4XTJ A;  4X64 I;  4FW4 A;  3J80 Q;  5LMU E;  4FW9 A;  4DPX A;  4X62 I;  4WUC A;  3JAM C;  4IFD A;  2LJP A;  2OI2 A;  3L7Z B;  1IBM E;  3CDI A;  4JI7 I;  3J7A M;  1XMQ I;  4IFD F;  4X66 I;  1I94 E;  1N34 E;  4OX9 I;  3V5R A;  3ZZU A;  4K0K E;  3P76 A;  4USM A;  2PO0 B;  2HK2 A;  4FWG A;  4B3S I;  4YY3 I;  2JT2 A;  1XHK A;  5FLX C;  2BR2 B;  3P3E A;  1YH8 A;  3Q6M A;  4X65 E;  4DV4 I;  1ZXN A;  2PO1 A;  4OO1 E;  1Z0W A;  2J7K A;  3CWV A;  4LFC I;  1UDN A;  2NN6 E;  2CVE A;  4DXL A;  3WU3 A;  5K36 B;  3HUL A;  1Y6Z A;  2O1V A;  2HKE A;  4M1K A;  4DV0 E;  4HYM A;  2BA0 G;  4B3T E;  4FW3 A;  5C0X C;  3T1Y I;  5BR8 I;  1XNR I;  1RRE A;  2JEB B;  1ZXM A;  3OTO E;  1FJG I;  2X7I A;  1Z5A A;  4MYT A;  4JI4 E;  4HXZ A;  4U3B A;  4DR5 E;  1Z0G A;  1XXE A;  1ELO A;  4JG4 A;  1N33 I;  1S16 A;  2JEA B;  1U2R A;  1Z0B A;  4YHH E;  2UXD E;  2C38 B;  3T1H E;  2Z5C B;  1B63 A;  2UXC E;  1H7U A;  5LMN E;  5A2Q C;  2ZBK B;  1NHI A;  2C37 A;  3QT8 A;  5DRQ A;  2PNZ A;  4JI8 E;  2R3V A;  1HR0 E;  4OO1 A;  4OZE A;  2GQ0 A;  5LL6 R;  4DR1 E;  2UUA I;  4LF7 E;  3UHM A;  4ISA A;  4GKJ I;  4OO1 F;  1OYR A;  5LMU I;  4JI6 E;  2NN6 F;  2AE8 A;  4KHP E;  5JEA E;  1S4E A;  4AQY I;  2A2D A;  2V2Q A;  2IOQ A;  5IWA I;  2UUC I;  4LPF A;  4HAC B;  2ZM6 E;  4DV6 E;  1Z5B A;  3WU4 A;  4JI0 I;  2V2Z A;  1NHJ A;  4BA2 A;  1PIE A;  4DR3 E;  4URL A;  3J80 C;  4LFA I;  2HFS A;  2HHH E;  4LF6 E;  4NXN E;  4LF8 E;  2C39 A;  1IBL E;  3PYE A;  1IBK E;  3PYF A;  4DV0 I;  2UXB I;  1QZR A;  4IS9 A;  4IZK B;  5DRO A;  1Z0C A;  4DUY E;  2VF3 A;  2Q2E B;  4DR7 E;  2WW4 A;  2BM0 A;  1H7S A;  3LNU A;  3U1Y A;  5JEA A;  1ZM9 A;  4JI1 E;  4QNK A;  2VES A;  5K36 D;  4DR2 E;  4Z7Y A;  5JEA F;  5ELW A;  4IFD B;  2E5L E;  3M7N D;  4FWD A;  1P42 A;  2UXC I;  4MU0 A;  3J81 C;  2V34 A;  2PNL A;  1RR9 A;  2WNR A;  2VQE I;  4DR1 I;  4ZVI A;  2JE6 A;  4Z7C A;  4NBQ A;  1OJ4 A;  5EKW A;  4HY1 A;  1H73 A;  2PO1 B;  4LCG A;  4KHP I;  1UDS A;  1J5E E;  3NZK A;  4FN5 A;  3HJC A;  2AJ4 A;  4B3M E;  1FKA E;  1ZM4 A;  2Z5E A;  1XNQ I;  2X36 A;  3F0N A;  3KRN A;  4DU7 A;  3H4L A;  2VQF E;  1PKP A;  2NN6 D;  3QT5 A;  1ZM2 A;  5DNL A;  1Z0V A;  3Q6N A;  4MU3 A;  4DR3 I;  2HHH I;  4LF6 I;  4NXM E;  5C0X A;  1Z0E A;  1UDO A;  4DV1 I;  1IBK I;  5C0X F;  5K36 C;  1YHC A;  2Z5B A;  4J3D A;  2GO4 A;  4DV2 E;  4DPY A;  4MQY A;  2IOP A;  3CDJ A;  3M85 G;  2O3Z A;  5GMD A;  3GLL A;  3PRY A;  1H74 A;  2GS8 A;  2BA1 G;  1N32 E;  4IZJ D;  4B3R I;  4DUY I;  4DV7 I;  4DV6 I;  4FW5 A;  4JV5 I;  4JI3 E;  1HNW E;  3B78 A;  2C37 B;  4LF9 E;  2PNZ B;  4DV3 I;  2IES A;  3PYG A;  4OO1 B;  2F4V I;  4JI2 I;  1EI1 A;  2BM1 A;  3DD6 A;  2NN6 B;  3Q1Q A;  1WUU A;  5DRR A;  4DR2 I;  1XMO I;  1HNZ E;  3ZM7 A;  1KTV A;  4DR4 E;  2E5L I;  4LCF A;  4LFB E;  4UTG A;  4WUD A;  4P52 A;  1IBM I;  4X64 E;  3ZZ0 A;  1I94 I;  1N34 I;  4X62 E;  4K0K I;  2NN6 C;  4JI7 E;  4R1F A;  4LF4 E;  1XMQ E;  4FWH A;  4X66 E;  4IZJ B;  1DAR A;  4BA2 B;  4OX9 E;  4BA1 A;  2CG9 A;  3B4T A;  3P06 A;  4X65 I;  3GME A;  1N0V C;  1PVG A;  2O1W A;  4MDT A;  2C39 B;  3LPS A;  4B3S E;  4YY3 E;  4DV5 E;  4IFD D;  1UEK A;  2EFG A;  1Y4U A;  4P7A A;  4DV4 E;  5IT9 Q;  4LFC E;  2VQF I;  2PNM A;  2DEI A;  4B3T I;  1VIS A;  4MU1 A;  3ZZT A;  4EMD A;  1D6T A;  1Z5C A;  4U3D A;  2O1T A;  2BA0 D;  2WP8 A;  3OTO I;  4JI4 I;  2DEJ A;  5BR8 E;  1XNR E;  5JEA B;  4DR5 I;  4LOM A;  4MU4 A;  1FJG E;  4ED4 A;  5A2Q Q;  4PRX A;  4JI5 E;  1EA6 A;  4YHH I;  5C0X E;  1N36 E;  1N32 I;  4UT4 A;  4N3O A;  1Y4S A;  1N33 E;  2UXD I;  1HK7 A;  4MYU A;  3T1H I;  4LCH A;  3M85 D;  4LF5 E;  4LF9 I;  2WNR B;  5LMN I;  1K47 A;  4IZK A;  4JI8 I;  2UU9 E;  2PO2 A;  1HR0 I;  5FWK A;  4LF7 I;  5L3J A;  3PS3 A;  1FNM A;  4DPT A;  4JI6 I;  4GKK E;  2UUA E;  4IFD C;  2HFU A;  4GKJ E;  1E3P A;  1UDQ A;  1FWL A;  2ZM6 I;  1KKH A;  4AQY E;  4GQU A;  3QT7 A;  4LF4 I;  1BKN A;  1Z59 A;  1MX0 A;  4OO1 D;  3B8H A;  1NHH A;  3L7Z A;  5IWA E;  3P3C A;  2UUC E;  1FI4 A;  4PU9 A;  5C0X B;  4DV5 I;  4JI0 E;  2PO0 A;  4NXN I;  4LF8 I;  3K85 A;  2Z5B B;  3ZKB A;  4WUB A;  3ZKD A;  1IBL I;  1FWK A;  5K36 E;  4LFA E;  2BR2 A;  4USK A;  4AIM A;  1OYP A;  2V2V A;  5K36 A;  1R6L A;  3K1J A;  2UXB E;  4DPU A;  5K36 F;  2E1R A;  3B82 A;  4DUZ E;  4DR7 I;  3JAM Q;  3J81 Q;  2UUB E;  2JEB A;  1USU A;  2HK3 A;  4JI1 I;  3T1Y E;  4JI5 I;  4JYA E;  1USV A;  5IT9 C;  2BV3 A;  1N36 I;  3PS2 A;  1MU5 A;  1KIJ A;  4DR6 E;  1HNX E;  3M7N G;  4LF5 I;  5FLX Q;  1RHY A;  1B62 A;  2JEA A;  4DV7 E;  2A2C A;  3M6A A;  5DRP A;  2UU9 I;  4OO1 C;  2CZ9 A;  4DPW A;  3U1K A;  5JEA D;  1H72 C;  2C38 A;  4BA1 B;  2Z5C A;  2J65 A;  4GKK I;  2VQE E;  1OYS A;  3K17 A;  2NN6 A;  2ZIT A;  1J5E I;  4B3M I;  3H1C A;  1Y5Y A;  2O1U A;  2XEX A;  3LTO A;  1Z0T A;  1ZM3 A;  2V8P A;  3WU6 A;  1MG7 A;  4AID A;  2GO3 A;  5GME A;  1XNQ E;  2WP8 B;  4IFD E;  1A6F A;  4HAC A;  1Y60 A;  3PYD A;  4QNJ A;  4FW7 A;  4NXM I;  4IZJ A;  1VI7 A;  4FW6 A;  4PRV A;  1KVK A;  2F1D A;  3P3G A;  4KQV A;  4DV2 I;  2IER A;  3GCM A;  5DNX A;  4RPF A;  4DV1 E;  1R6M A;  4I3H A;  4OKG A;  3HKM A;  2HKJ A;  3QT6 A;  2R42 A;  4DUZ I;  4JI3 I;  1HNW I;  2CGE A;  3J7A G;  2BA1 D;  2PO2 B;  2NPF A;  5C0X D;  2UUB I;  4B3R E;  2JE6 B;  5JEA C;  5EL9 A;  1E3H A;  3WU5 A; 
#chains in the Genus database with same CATH homology
 2J65 A;  4FW7 A;  3PS3 A;  5DRQ A;  4OZE A;  2JT2 A;  4FW6 A;  5DRR A;  4MDT A;  3U1Y A;  3UHM A;  4U3B A;  3P3G A;  4LCG A;  4ISA A;  3P3E A;  1YH8 A;  2VES A;  2IER A;  3PS2 A;  1XXE A;  1YHC A;  4J3D A;  3NZK A;  3PS1 A;  4LCF A;  2GO4 A;  4MQY A;  4FW4 A;  4OKG A;  2O3Z A;  1P42 A;  2GO3 A;  4LCH A;  5DRP A;  4FW3 A;  4FW5 A;  4IS9 A;  5DRO A;  4U3D A;  3P3C A;  3P76 A;  2IES A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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