3P3CA

Crystal structure of the aquifex aeolicus lpxc/lpc-009 complex
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
272
structure length
272
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQKLTRDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
pubmed doi rcsb
source organism Aquifex aeolicus
molecule tags Hydrolase
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 86
structure length 272
sequence length 272
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2010-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3p3cA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3p3cA02
2GO4A 3NZKA 4LCFA 3P76A 4LCHA 3UHMA 3PS3A 4OZEA 4FW7A 2VESA 3U1YA 1XXEA 4U3DA 2GO3A 2IESA 3PS1A 2J65A 3P3CA 3PS2A 4FW4A 2O3ZA 4U3BA 1YHCA 4LCGA 4ISAA 1P42A 2IERA 5DRQA 4FW5A 2JT2A 4FW3A 4MDTA 4IS9A 4FW6A 4OKGA 5DRPA 5DROA 4J3DA 1YH8A 4MQYA 3P3GA 3P3EA 5DRRA
chains in the Genus database with same CATH superfamily
2GS8A 4OO1E 2V2ZA 4DR4E 4IFDD 4X65I 2Z5BB 5FLXQ 3QT7A 1Z5CA 4DUZE 4OZEA 4DUYE 2HKEA 4JYAI 4IFDA 1B62A 4IZJB 4IZJA 2GO3A 2XEXA 3U1KA 1BKNA 4DR2E 4U3BA 1N34E 4DR3E 5K36A 4NXME 2C39A 3GLLA 1XNQE 4DV3E 1I94I 4OO1A 2UUAI 2CVEA 2CZ9A 1N0UA 4ZVIA 4I3HA 4M1KA 4HACA 2PNZA 4IFDE 1MG7A 3P76A 1NHJA 5BR8I 4B3SE 2C37B 3QT8A 5K36E 1OYPA 1H74A 1IBLE 4OX9E 2BA1D 3V5RA 4AIDA 3WU5A 1FWLA 2O3ZA 2E5LI 2VQEI 3WU6A 2EFGA 5JEAF 1Y5YA 5GMEA 5DROA 4LFBI 4HACB 1UEKA 4MU1A 3JAMC 4IFDF 1H72C 4LF9I 3M85D 1OYSA 4PRXA 1HNWI 1ZM3A 3L7ZB 4DR6I 4LCFA 4DR3I 5K36F 3L7ZA 4DU8A 3PS3A 1USUA 1IBKI 3ZZUA 3M7NG 1NHIA 1OJ4A 4DUYI 2VQEE 4DR1I 3HKMA 5JEAE 4HYMA 4GQUA 4DR4I 4IZKA 4OKGA 2A2CA 4JI7E 1FI4A 5JEAB 4LFCI 4JI3E 1FWKA 1N33E 3ZM7A 2Z5EA 5IT9C 3JAMQ 5IWAI 3ZZTA 3DD6A 4DV6E 1Z0TA 4OO1D 2JEAA 4BA1A 1N32I 4DV3I 2PNLA 2VESA 1A6FA 4JV5E 5JEAA 3KRNA 4QNKA 1Z0BA 2HHHI 3J80C 4LF4E 2BA0G 3B4TA 4LF7E 4DV4I 4OX9I 2A2DA 4LPFA 1XHKA 4FWDA 4FWHA 4MQYA 1IBMI 4LF8I 3P3EA 4USKA 1MX0A 4LF4I 2VQFI 2C39B 1UDSA 4EMDA 4OO1C 1KIJA 4P7AA 2UUAE 4Z7CA 1ZM4A 1J5EE 2IESA 5DNXA 4K0KE 3P3CA 1XNQI 1XMQI 4AIMA 1H73A 3F0NA 1PVGA 5JEAD 4DXLA 4HY1A 1UDNA 2UXBI 2WP8A 4RPFA 2C38A 4N3OA 1Z0GA 4DV5E 2PO1A 1KKHA 4NBQA 4LF5I 4NXNE 3P3GA 1Y4UA 1Z0CA 4AQYE 1FJGE 3J7AM 4LCHA 4P52A 3UHMA 4DV5I 1XXEA 5LMNE 1N36I 2UU9E 4FW4A 4DR6E 1Z5BA 4B3TE 4MYTA 1I94E 4JI5I 2F4VI 2JEBA 4JI8I 5IWAE 4JI6I 2JEAB 3PRYA 2Z5CB 4JI1I 1HNXI 1XNRI 2NN6F 3PYGA 1Y60A 4KHPE 4LFAE 4FW9A 3T1YE 5FLXC 2UUCI 4WUDA 3H1CA 1QZRA 4YY3I 5C0XE 2ZM6I 1Z0WA 4DPUA 4X66E 3GONA 2V34A 1UDOA 4JI0I 1ZXMA 5C0XD 1VI7A 4DR7I 4HXZA 1WUUA 2JE6A 4MU4A 4FN5A 5JEAC 4JI2I 3GCMA 4FW6A 2WNRA 4J3DA 4JI8E 1FKAE 4JI6E 1N32E 1NHHA 5C0XA 1Y4SA 4DV7I 2BM1A 1N0VC 5C0XF 3ZKBA 4WUCA 2J7KA 3Q6MA 4JI3I 3Q6NA 2IOQA 4DV0I 3B82A 4DV1E 5GMDA 3LPSA 4DPTA 1Z0EA 2BA0D 1DARA 4BA2B 1HNZI 4BA1B 4DR1E 4DV2E 1OYRA 2UUCE 5EKWA 4DR5I 2ZITA 2UXBE 2O1VA 2UXCE 3OTOE 4ED4A 3J81Q 1EI1A 4B3RI 2UXDI 5A2QQ 2F1DA 2GO4A 1Z5AA 3OTOI 2DEJA 1RHYA 4DR2I 2V8PA 2HFUA 4LFCE 4DR7E 4DPXA 4LF8E 3ZKDA 2E5LE 2PNMA 1HNZE 4X65E 1B63A 4PU9A 3B78A 4DV4E 4B3SI 4JI4E 4DV0E 4DPWA 1FNMA 4OO1F 1E3HA 2PO0A 5L3JA 1HR0I 1HNWE 1S16A 2DEIA 1Z0VA 4JV5I 4KQVA 2F4VE 4LF9E 2J65A 2ZBKB 2HK3A 2JEBB 3PYFA 5EL9A 5DNLA 3T1HI 2IERA 4JI4I 5C0XB 2BV3A 4DUZI 5LMUI 3Q1QA 3WU3A 5DRRA 1VISA 5DRPA 5FWKA 1R6MA 4YY3E 2OI2A 4UT4A 5BR8E 2JE6B 2ZM6E 2BR2A 1UDQA 4GKJE 2BM0A 1U2RA 4LOMA 1PIEA 4DV1I 2PO2B 2NN6D 2WNRB 2HFSA 1Y6ZA 1XMQE 4URLA 3PS2A 4USMA 1XMOI 1PKPA 2BR2B 3D4JA 4K0KI 4LCGA 1H7UA 1P42A 4MU0A 4JG4A 2JT2A 4B3TI 2WW4A 4JI2E 5C0XC 5LL6R 3H4LA 3CDIA 3J81C 1K47A 3K1JA 1ZM9A 4YHHI 4DU7A 4JI0E 4Z7YA 2NN6C 1FJGI 4X66I 1IBLI 3QT6A 3V2UC 4NXNI 3PYEA 5LMUE 3CDJA 4LF6I 4YHHE 4PRVA 3P06A 1YHCA 4OO1B 3J80Q 1XMOE 5IT9Q 2WP8B 4LFBE 1Z59A 3K17A 4XTJA 2UXCI 1HR0E 1N36E 2UU9I 3B8HA 3K85A 1NZ0A 2VQFE 2C38B 2PO1B 2V2QA 2O1TA 2R42A 2CGEA 4UTGA 4LF5E 2Z5BA 3M6AA 4LFAI 2VF3A 3T1HE 1HNXE 4JI1E 5K36D 2X36A 2C37A 1YH8A 2NPFA 4AM3A 1R6LA 3M85G 2HK2A 2NN6E 1S4EA 4JI5E 4B3RE 3NZKA 1N34I 4X62E 4X64I 5K36C 4FW7A 1N33I 2GQ0A 3LTOA 3U1YA 4DPYA 2LJPA 2BA1G 2Q2EB 2V2VA 4ISAA 5DRQA 2AJ4A 4MDTA 4IS9A 2NN6A 4MU3A 2O1WA 2R3VA 3WU4A 5ELWA 2HHHE 1KTVA 1XNRE 4X62I 3PYDA 4X64E 4GKKE 2CG9A 5A2QC 1D6TA 1E3PA 4U3DA 2UXDE 3HJCA 3M7ND 3PS1A 1RR9A 1MU5A 4GKKI 2Z5CA 2NN6B 1ELOA 1USVA 4JI7I 5K36B 4LF6E 4DV2I 2HKJA 1ZXNA 3QT5A 2E1RA 3HULA 1IBME 4B3MI 2PO2A 4AQYI 4B3ME 4IFDB 4LF7I 1ZM2A 3GMEA 3LNUA 4KHPI 1KVKA 3T1YI 1IBKE 4WUBA 3ZZ0A 3J7AG 1HK7A 2UUBI 3CWVA 2IOPA 2X7IA 4DV7E 4DV6I 1J5EI 4FWGA 4MYUA 2PNZB 4FW5A 2UUBE 4FW3A 2O1UA 4NXMI 4BA2A 2PO0B 1EA6A 5LMNI 1H7SA 4IZKB 4QNJA 4R1FA 4DR5E 1RREA 4JYAE 2AE8A 4IZJD 4IFDC 4GKJI
chains in the Genus database with same CATH topology
2GO4A 3NZKA 4LCFA 3P76A 4LCHA 3UHMA 3PS3A 4OZEA 4FW7A 2VESA 3U1YA 1XXEA 4U3DA 2GO3A 2IESA 3PS1A 2J65A 3P3CA 3PS2A 4FW4A 2O3ZA 4U3BA 1YHCA 4LCGA 4ISAA 1P42A 2IERA 5DRQA 4FW5A 2JT2A 4FW3A 4MDTA 4IS9A 4FW6A 4OKGA 5DRPA 5DROA 4J3DA 1YH8A 4MQYA 3P3GA 3P3EA 5DRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GO4 A;  3NZK A;  4LCF A;  3P76 A;  4LCH A;  3UHM A;  3PS3 A;  4OZE A;  4FW7 A;  2VES A;  3U1Y A;  1XXE A;  4U3D A;  2GO3 A;  2IES A;  3PS1 A;  2J65 A;  3P3C A;  3PS2 A;  4FW4 A;  2O3Z A;  4U3B A;  1YHC A;  4LCG A;  4ISA A;  1P42 A;  2IER A;  5DRQ A;  4FW5 A;  2JT2 A;  4FW3 A;  4MDT A;  4IS9 A;  4FW6 A;  4OKG A;  5DRP A;  5DRO A;  4J3D A;  1YH8 A;  4MQY A;  3P3G A;  3P3E A;  5DRR A; 
#chains in the Genus database with same CATH topology
 2GS8 A;  4OO1 E;  2V2Z A;  4DR4 E;  4IFD D;  4X65 I;  2Z5B B;  5FLX Q;  3QT7 A;  1Z5C A;  4DUZ E;  4OZE A;  4DUY E;  2HKE A;  4JYA I;  4IFD A;  1B62 A;  4IZJ B;  4IZJ A;  2GO3 A;  2XEX A;  3U1K A;  1BKN A;  4DR2 E;  4U3B A;  1N34 E;  4DR3 E;  5K36 A;  4NXM E;  2C39 A;  3GLL A;  1XNQ E;  4DV3 E;  1I94 I;  4OO1 A;  2UUA I;  2CVE A;  2CZ9 A;  1N0U A;  4ZVI A;  4I3H A;  4M1K A;  4HAC A;  2PNZ A;  4IFD E;  1MG7 A;  3P76 A;  1NHJ A;  5BR8 I;  4B3S E;  2C37 B;  3QT8 A;  5K36 E;  1OYP A;  1H74 A;  1IBL E;  4OX9 E;  2BA1 D;  3V5R A;  4AID A;  3WU5 A;  1FWL A;  2O3Z A;  2E5L I;  2VQE I;  3WU6 A;  2EFG A;  5JEA F;  1Y5Y A;  5GME A;  5DRO A;  4LFB I;  4HAC B;  1UEK A;  4MU1 A;  3JAM C;  4IFD F;  1H72 C;  4LF9 I;  3M85 D;  1OYS A;  4PRX A;  1HNW I;  1ZM3 A;  3L7Z B;  4DR6 I;  4LCF A;  4DR3 I;  5K36 F;  3L7Z A;  4DU8 A;  3PS3 A;  1USU A;  1IBK I;  3ZZU A;  3M7N G;  1NHI A;  1OJ4 A;  4DUY I;  2VQE E;  4DR1 I;  3HKM A;  5JEA E;  4HYM A;  4GQU A;  4DR4 I;  4IZK A;  4OKG A;  2A2C A;  4JI7 E;  1FI4 A;  5JEA B;  4LFC I;  4JI3 E;  1FWK A;  1N33 E;  3ZM7 A;  2Z5E A;  5IT9 C;  3JAM Q;  5IWA I;  3ZZT A;  3DD6 A;  4DV6 E;  1Z0T A;  4OO1 D;  2JEA A;  4BA1 A;  1N32 I;  4DV3 I;  2PNL A;  2VES A;  1A6F A;  4JV5 E;  5JEA A;  3KRN A;  4QNK A;  1Z0B A;  2HHH I;  3J80 C;  4LF4 E;  2BA0 G;  3B4T A;  4LF7 E;  4DV4 I;  4OX9 I;  2A2D A;  4LPF A;  1XHK A;  4FWD A;  4FWH A;  4MQY A;  1IBM I;  4LF8 I;  3P3E A;  4USK A;  1MX0 A;  4LF4 I;  2VQF I;  2C39 B;  1UDS A;  4EMD A;  4OO1 C;  1KIJ A;  4P7A A;  2UUA E;  4Z7C A;  1ZM4 A;  1J5E E;  2IES A;  5DNX A;  4K0K E;  3P3C A;  1XNQ I;  1XMQ I;  4AIM A;  1H73 A;  3F0N A;  1PVG A;  5JEA D;  4DXL A;  4HY1 A;  1UDN A;  2UXB I;  2WP8 A;  4RPF A;  2C38 A;  4N3O A;  1Z0G A;  4DV5 E;  2PO1 A;  1KKH A;  4NBQ A;  4LF5 I;  4NXN E;  3P3G A;  1Y4U A;  1Z0C A;  4AQY E;  1FJG E;  3J7A M;  4LCH A;  4P52 A;  3UHM A;  4DV5 I;  1XXE A;  5LMN E;  1N36 I;  2UU9 E;  4FW4 A;  4DR6 E;  1Z5B A;  4B3T E;  4MYT A;  1I94 E;  4JI5 I;  2F4V I;  2JEB A;  4JI8 I;  5IWA E;  4JI6 I;  2JEA B;  3PRY A;  2Z5C B;  4JI1 I;  1HNX I;  1XNR I;  2NN6 F;  3PYG A;  1Y60 A;  4KHP E;  4LFA E;  4FW9 A;  3T1Y E;  5FLX C;  2UUC I;  4WUD A;  3H1C A;  1QZR A;  4YY3 I;  5C0X E;  2ZM6 I;  1Z0W A;  4DPU A;  4X66 E;  3GON A;  2V34 A;  1UDO A;  4JI0 I;  1ZXM A;  5C0X D;  1VI7 A;  4DR7 I;  4HXZ A;  1WUU A;  2JE6 A;  4MU4 A;  4FN5 A;  5JEA C;  4JI2 I;  3GCM A;  4FW6 A;  2WNR A;  4J3D A;  4JI8 E;  1FKA E;  4JI6 E;  1N32 E;  1NHH A;  5C0X A;  1Y4S A;  4DV7 I;  2BM1 A;  1N0V C;  5C0X F;  3ZKB A;  4WUC A;  2J7K A;  3Q6M A;  4JI3 I;  3Q6N A;  2IOQ A;  4DV0 I;  3B82 A;  4DV1 E;  5GMD A;  3LPS A;  4DPT A;  1Z0E A;  2BA0 D;  1DAR A;  4BA2 B;  1HNZ I;  4BA1 B;  4DR1 E;  4DV2 E;  1OYR A;  2UUC E;  5EKW A;  4DR5 I;  2ZIT A;  2UXB E;  2O1V A;  2UXC E;  3OTO E;  4ED4 A;  3J81 Q;  1EI1 A;  4B3R I;  2UXD I;  5A2Q Q;  2F1D A;  2GO4 A;  1Z5A A;  3OTO I;  2DEJ A;  1RHY A;  4DR2 I;  2V8P A;  2HFU A;  4LFC E;  4DR7 E;  4DPX A;  4LF8 E;  3ZKD A;  2E5L E;  2PNM A;  1HNZ E;  4X65 E;  1B63 A;  4PU9 A;  3B78 A;  4DV4 E;  4B3S I;  4JI4 E;  4DV0 E;  4DPW A;  1FNM A;  4OO1 F;  1E3H A;  2PO0 A;  5L3J A;  1HR0 I;  1HNW E;  1S16 A;  2DEI A;  1Z0V A;  4JV5 I;  4KQV A;  2F4V E;  4LF9 E;  2J65 A;  2ZBK B;  2HK3 A;  2JEB B;  3PYF A;  5EL9 A;  5DNL A;  3T1H I;  2IER A;  4JI4 I;  5C0X B;  2BV3 A;  4DUZ I;  5LMU I;  3Q1Q A;  3WU3 A;  5DRR A;  1VIS A;  5DRP A;  5FWK A;  1R6M A;  4YY3 E;  2OI2 A;  4UT4 A;  5BR8 E;  2JE6 B;  2ZM6 E;  2BR2 A;  1UDQ A;  4GKJ E;  2BM0 A;  1U2R A;  4LOM A;  1PIE A;  4DV1 I;  2PO2 B;  2NN6 D;  2WNR B;  2HFS A;  1Y6Z A;  1XMQ E;  4URL A;  3PS2 A;  4USM A;  1XMO I;  1PKP A;  2BR2 B;  3D4J A;  4K0K I;  4LCG A;  1H7U A;  1P42 A;  4MU0 A;  4JG4 A;  2JT2 A;  4B3T I;  2WW4 A;  4JI2 E;  5C0X C;  5LL6 R;  3H4L A;  3CDI A;  3J81 C;  1K47 A;  3K1J A;  1ZM9 A;  4YHH I;  4DU7 A;  4JI0 E;  4Z7Y A;  2NN6 C;  1FJG I;  4X66 I;  1IBL I;  3QT6 A;  3V2U C;  4NXN I;  3PYE A;  5LMU E;  3CDJ A;  4LF6 I;  4YHH E;  4PRV A;  3P06 A;  1YHC A;  4OO1 B;  3J80 Q;  1XMO E;  5IT9 Q;  2WP8 B;  4LFB E;  1Z59 A;  3K17 A;  4XTJ A;  2UXC I;  1HR0 E;  1N36 E;  2UU9 I;  3B8H A;  3K85 A;  1NZ0 A;  2VQF E;  2C38 B;  2PO1 B;  2V2Q A;  2O1T A;  2R42 A;  2CGE A;  4UTG A;  4LF5 E;  2Z5B A;  3M6A A;  4LFA I;  2VF3 A;  3T1H E;  1HNX E;  4JI1 E;  5K36 D;  2X36 A;  2C37 A;  1YH8 A;  2NPF A;  4AM3 A;  1R6L A;  3M85 G;  2HK2 A;  2NN6 E;  1S4E A;  4JI5 E;  4B3R E;  3NZK A;  1N34 I;  4X62 E;  4X64 I;  5K36 C;  4FW7 A;  1N33 I;  2GQ0 A;  3LTO A;  3U1Y A;  4DPY A;  2LJP A;  2BA1 G;  2Q2E B;  2V2V A;  4ISA A;  5DRQ A;  2AJ4 A;  4MDT A;  4IS9 A;  2NN6 A;  4MU3 A;  2O1W A;  2R3V A;  3WU4 A;  5ELW A;  2HHH E;  1KTV A;  1XNR E;  4X62 I;  3PYD A;  4X64 E;  4GKK E;  2CG9 A;  5A2Q C;  1D6T A;  1E3P A;  4U3D A;  2UXD E;  3HJC A;  3M7N D;  3PS1 A;  1RR9 A;  1MU5 A;  4GKK I;  2Z5C A;  2NN6 B;  1ELO A;  1USV A;  4JI7 I;  5K36 B;  4LF6 E;  4DV2 I;  2HKJ A;  1ZXN A;  3QT5 A;  2E1R A;  3HUL A;  1IBM E;  4B3M I;  2PO2 A;  4AQY I;  4B3M E;  4IFD B;  4LF7 I;  1ZM2 A;  3GME A;  3LNU A;  4KHP I;  1KVK A;  3T1Y I;  1IBK E;  4WUB A;  3ZZ0 A;  3J7A G;  1HK7 A;  2UUB I;  3CWV A;  2IOP A;  2X7I A;  4DV7 E;  4DV6 I;  1J5E I;  4FWG A;  4MYU A;  2PNZ B;  4FW5 A;  2UUB E;  4FW3 A;  2O1U A;  4NXM I;  4BA2 A;  2PO0 B;  1EA6 A;  5LMN I;  1H7S A;  4IZK B;  4QNJ A;  4R1F A;  4DR5 E;  1RRE A;  4JYA E;  2AE8 A;  4IZJ D;  4IFD C;  4GKJ I; 
#chains in the Genus database with same CATH homology
 2GO4 A;  3NZK A;  4LCF A;  3P76 A;  4LCH A;  3UHM A;  3PS3 A;  4OZE A;  4FW7 A;  2VES A;  3U1Y A;  1XXE A;  4U3D A;  2GO3 A;  2IES A;  3PS1 A;  2J65 A;  3P3C A;  3PS2 A;  4FW4 A;  2O3Z A;  4U3B A;  1YHC A;  4LCG A;  4ISA A;  1P42 A;  2IER A;  5DRQ A;  4FW5 A;  2JT2 A;  4FW3 A;  4MDT A;  4IS9 A;  4FW6 A;  4OKG A;  5DRP A;  5DRO A;  4J3D A;  1YH8 A;  4MQY A;  3P3G A;  3P3E A;  5DRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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