1YH8A

Crystal structure of aquifex aeolicus lpxc deacetylase complexed with palmitate
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
266
structure length
266
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 86
structure length 266
sequence length 266
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2005-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 1yh8A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 1yh8A02
4FW6A 4OZEA 4FW4A 3PS1A 1XXEA 3PS2A 2IERA 5DRRA 2O3ZA 2JT2A 3P3GA 4OKGA 2IESA 4LCFA 4LCGA 1P42A 1YHCA 4U3DA 5DROA 2J65A 3P76A 4FW7A 5DRQA 4ISAA 3PS3A 4FW3A 4U3BA 2GO4A 3UHMA 5DRPA 4J3DA 4MQYA 4IS9A 4LCHA 2VESA 4FW5A 4MDTA 3NZKA 2GO3A 1YH8A 3P3CA 3U1YA 3P3EA
chains in the Genus database with same CATH superfamily
2EFGA 2UXDE 4NXMI 1S4EA 4BA1A 4JI4I 4AM3A 3GMEA 5LMUE 1IBME 4DV1I 4FWGA 1ZXMA 4ED4A 3Q6NA 3QT7A 4PRVA 4NBQA 1N36E 2PNMA 4MQYA 5C0XC 4IFDF 1IBKI 3PYEA 1YH8A 4X66E 2LJPA 5FLXC 1D6TA 1Z0TA 1OYSA 4OO1F 4X65I 2HHHI 2Q2EB 2UXBE 3Q6MA 4HXZA 3PS2A 1H74A 1Y60A 5JEAB 5IT9Q 4IFDE 4LF8I 3M85G 1RHYA 2V2QA 4FW7A 5JEAA 2VQEI 4JI3I 1ELOA 2Z5BA 2V2ZA 4UTGA 4X64E 4OX9I 4DPXA 1MX0A 4XTJA 4DR3I 4LFCI 4DR2E 3P3CA 1Z0CA 2WNRA 2UXDI 2JEBA 4JI8E 4GKJE 4PRXA 5K36B 1ZM9A 1J5EE 1I94E 1HNXE 2JEAB 4K0KE 2PO0A 4DV3E 3OTOE 4LF9E 5LMUI 2IERA 5K36A 2UU9I 2JEAA 3ZZ0A 3PYDA 4MU3A 1ZM2A 2UXCE 1ZM3A 4LCGA 2NN6B 4DR1E 1MG7A 1N36I 3K1JA 1FNMA 2NN6A 3J80Q 5DRPA 4B3ME 4DR6I 1E3HA 4FW5A 4X66I 4DPUA 2CGEA 3GONA 3M7ND 2UXBI 4DV7I 3PS1A 5GMEA 5C0XF 2R42A 1MU5A 1Y6ZA 2PNZB 1Z0EA 4USKA 4MU1A 4HACB 4IFDD 3P76A 3ZZTA 3JAMC 4X64I 5IWAI 4DR2I 3M7NG 4JI8I 4DV2E 4GKJI 3J81C 1HNXI 4K0KI 1HNWI 4FW6A 4FW4A 1KKHA 3OTOI 4LF9I 5EKWA 2C37B 4DUYE 1Z59A 1HR0E 1Y4UA 4BA2A 2UXCI 3CDIA 4IZJB 1USVA 4BA1B 2E1RA 3H1CA 3K17A 2O1UA 4DR1I 4B3TE 4JI1I 4IZJA 1XNRE 2A2DA 2UUAE 4B3MI 4N3OA 4P7AA 4Z7YA 5DNLA 3P3EA 4LPFA 1H72C 3B82A 1XXEA 1Y4SA 4FWDA 4IZKB 4JI0E 1Z5BA 4I3HA 1KVKA 4IZKA 4PU9A 2HFSA 4LFBE 3ZKDA 2PO1B 4JI7I 1ZM4A 4ISAA 2PO1A 3ZM7A 4DV2I 2Z5EA 5C0XD 1N32E 3NZKA 3U1YA 2CG9A 3Q1QA 1NHIA 4JYAE 4DUYI 1HNZE 4QNKA 3H4LA 2BM1A 1HR0I 1FJGE 1PKPA 5JEAE 4LOMA 1Z5AA 5A2QC 3L7ZA 2UUCE 4B3TI 5ELWA 4KHPE 2BR2A 1XNRI 2BA1D 3PYFA 5DROA 4LF6E 2Z5BB 4FW3A 3PYGA 1RREA 2WNRB 2JEBB 3F0NA 4YY3I 5K36E 3V2UC 1NZ0A 2PO0B 2AJ4A 3ZKBA 1EI1A 4JI0I 2ZITA 4DPTA 1IBMI 4B3SE 1R6LA 4DUZE 2BA1G 4LFBI 3QT6A 2NN6E 1P42A 2GQ0A 1N0UA 3PRYA 4HYMA 3U1KA 2WW4A 4OO1B 4IFDA 4DV6E 1FKAE 1N32I 2Z5CA 4FN5A 1XMQE 1S16A 3WU5A 1OYPA 3LTOA 4GQUA 4OO1A 4DR5E 4JV5E 4JYAI 2C39B 1Z0VA 2UUBE 2HK3A 1NHJA 1B62A 2WP8A 4DU7A 3WU4A 1FJGI 2PO2B 3D4JA 2C39A 2DEIA 4AIDA 5BR8E 2UUCI 4RPFA 5JEAC 5JEAD 3T1YE 1OJ4A 2PO2A 4KHPI 3B8HA 4LCFA 1Z5CA 4LF6I 4U3DA 2J65A 2V2VA 1QZRA 5DRQA 3P06A 1FWLA 5IT9C 3PS3A 3ZZUA 4P52A 4DPYA 3B4TA 4LCHA 2C38A 2VF3A 2HKEA 5K36C 5K36D 1N33E 3V5RA 3DD6A 2VQFE 4DV5E 1J5EI 1I94I 4DV3I 2BA0D 4BA2B 4JI5E 1UDQA 4DUZI 4DR4E 1R6MA 4X62E 4JI2E 4DV1E 1B63A 2ZM6E 4DPWA 2NN6C 2NN6D 1PVGA 4ZVIA 4DU8A 5LMNE 4USMA 4DV6I 4DV4E 3K85A 3UHMA 5FLXQ 1XNQE 1E3PA 4DR5I 1KTVA 4JV5I 2CVEA 2UUBI 3J80C 2F1DA 2BA0G 4JI6E 4X65E 5C0XA 4FWHA 5FWKA 2OI2A 3J7AG 2ZBKB 4DR7E 5L3JA 1VI7A 1YHCA 2HK2A 1IBLE 2O1TA 4URLA 3GLLA 2V34A 5JEAF 4JI3E 1H73A 3HKMA 2R3VA 1N34E 1NHHA 4DR3E 4M1KA 1XHKA 2VQFI 1XMOE 4WUCA 4AQYE 4NXNE 2O1VA 2JE6A 4JI5I 5GMDA 1A6FA 5EL9A 2J7KA 4B3RE 4X62I 3L7ZB 4JI2I 4DR4I 4IZJD 4OKGA 3LNUA 2UU9E 2BR2B 2ZM6I 2XEXA 5K36F 3M6AA 2NPFA 1UDOA 3HJCA 1Z0BA 1OYRA 4MU4A 5LMNI 3HULA 3LPSA 4DV4I 2UUAI 3M85D 1XNQI 4YHHE 4JG4A 4IS9A 4DV0E 2NN6F 4DR6E 4JI6I 2A2CA 1Z0GA 1K47A 4OZEA 4DV7E 4LFCE 2HFUA 5DNXA 4DR7I 2GS8A 5DRRA 1ZXNA 2E5LE 4Z7CA 2JT2A 2HKJA 4WUBA 1N0VC 4GKKE 2IOPA 3JAMQ 1IBLI 4WUDA 3GCMA 1PIEA 4IFDB 4OO1E 4MU0A 4U3BA 2Z5CB 1RR9A 1N34I 5IWAE 3J81Q 3T1HE 4LF4E 1KIJA 1XMOI 4MDTA 4AQYI 2GO3A 3QT8A 4NXNI 2WP8B 4LFAE 1HNZI 1HNWE 2DEJA 1UDSA 1U2RA 4B3RI 1FWKA 2BV3A 1FI4A 2O3ZA 2IOQA 4LF7E 5LL6R 4DXLA 1EA6A 4FW9A 1H7SA 2X36A 4JI1E 4YHHI 2F4VE 2C38B 2CZ9A 4HY1A 4DV0I 4LF5E 4UT4A 2VESA 2PNLA 4QNJA 1UEKA 1BKNA 1Y5YA 4MYTA 2E5LI 4NXME 4GKKI 3WU3A 3WU6A 4B3SI 4KQVA 3P3GA 4JI4E 3J7AM 4MYUA 4IFDC 2PNZA 4EMDA 1Z0WA 3CDJA 1DARA 3QT5A 4HACA 4JI7E 4OO1C 4OO1D 2V8PA 3T1HI 4LF4I 1HK7A 5C0XE 1XMQI 4LFAI 5C0XB 1IBKE 3B78A 3CWVA 1WUUA 4R1FA 2HHHE 5A2QQ 5BR8I 3KRNA 4LF7I 2C37A 3T1YI 1VISA 2IESA 2AE8A 1UDNA 4AIMA 2F4VI 2BM0A 4LF8E 4LF5I 2GO4A 2VQEE 2O1WA 4J3DA 4YY3E 4OX9E 2X7IA 1USUA 1N33I 2JE6B 4DV5I 1H7UA
chains in the Genus database with same CATH topology
4FW6A 4OZEA 4FW4A 3PS1A 1XXEA 3PS2A 2IERA 5DRRA 2O3ZA 2JT2A 3P3GA 4OKGA 2IESA 4LCFA 4LCGA 1P42A 1YHCA 4U3DA 5DROA 2J65A 3P76A 4FW7A 5DRQA 4ISAA 3PS3A 4FW3A 4U3BA 2GO4A 3UHMA 5DRPA 4J3DA 4MQYA 4IS9A 4LCHA 2VESA 4FW5A 4MDTA 3NZKA 2GO3A 1YH8A 3P3CA 3U1YA 3P3EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FW6 A;  4OZE A;  4FW4 A;  3PS1 A;  1XXE A;  3PS2 A;  2IER A;  5DRR A;  2O3Z A;  2JT2 A;  3P3G A;  4OKG A;  2IES A;  4LCF A;  4LCG A;  1P42 A;  1YHC A;  4U3D A;  5DRO A;  2J65 A;  3P76 A;  4FW7 A;  5DRQ A;  4ISA A;  3PS3 A;  4FW3 A;  4U3B A;  2GO4 A;  3UHM A;  5DRP A;  4J3D A;  4MQY A;  4IS9 A;  4LCH A;  2VES A;  4FW5 A;  4MDT A;  3NZK A;  2GO3 A;  1YH8 A;  3P3C A;  3U1Y A;  3P3E A; 
#chains in the Genus database with same CATH topology
 2EFG A;  2UXD E;  4NXM I;  1S4E A;  4BA1 A;  4JI4 I;  4AM3 A;  3GME A;  5LMU E;  1IBM E;  4DV1 I;  4FWG A;  1ZXM A;  4ED4 A;  3Q6N A;  3QT7 A;  4PRV A;  4NBQ A;  1N36 E;  2PNM A;  4MQY A;  5C0X C;  4IFD F;  1IBK I;  3PYE A;  1YH8 A;  4X66 E;  2LJP A;  5FLX C;  1D6T A;  1Z0T A;  1OYS A;  4OO1 F;  4X65 I;  2HHH I;  2Q2E B;  2UXB E;  3Q6M A;  4HXZ A;  3PS2 A;  1H74 A;  1Y60 A;  5JEA B;  5IT9 Q;  4IFD E;  4LF8 I;  3M85 G;  1RHY A;  2V2Q A;  4FW7 A;  5JEA A;  2VQE I;  4JI3 I;  1ELO A;  2Z5B A;  2V2Z A;  4UTG A;  4X64 E;  4OX9 I;  4DPX A;  1MX0 A;  4XTJ A;  4DR3 I;  4LFC I;  4DR2 E;  3P3C A;  1Z0C A;  2WNR A;  2UXD I;  2JEB A;  4JI8 E;  4GKJ E;  4PRX A;  5K36 B;  1ZM9 A;  1J5E E;  1I94 E;  1HNX E;  2JEA B;  4K0K E;  2PO0 A;  4DV3 E;  3OTO E;  4LF9 E;  5LMU I;  2IER A;  5K36 A;  2UU9 I;  2JEA A;  3ZZ0 A;  3PYD A;  4MU3 A;  1ZM2 A;  2UXC E;  1ZM3 A;  4LCG A;  2NN6 B;  4DR1 E;  1MG7 A;  1N36 I;  3K1J A;  1FNM A;  2NN6 A;  3J80 Q;  5DRP A;  4B3M E;  4DR6 I;  1E3H A;  4FW5 A;  4X66 I;  4DPU A;  2CGE A;  3GON A;  3M7N D;  2UXB I;  4DV7 I;  3PS1 A;  5GME A;  5C0X F;  2R42 A;  1MU5 A;  1Y6Z A;  2PNZ B;  1Z0E A;  4USK A;  4MU1 A;  4HAC B;  4IFD D;  3P76 A;  3ZZT A;  3JAM C;  4X64 I;  5IWA I;  4DR2 I;  3M7N G;  4JI8 I;  4DV2 E;  4GKJ I;  3J81 C;  1HNX I;  4K0K I;  1HNW I;  4FW6 A;  4FW4 A;  1KKH A;  3OTO I;  4LF9 I;  5EKW A;  2C37 B;  4DUY E;  1Z59 A;  1HR0 E;  1Y4U A;  4BA2 A;  2UXC I;  3CDI A;  4IZJ B;  1USV A;  4BA1 B;  2E1R A;  3H1C A;  3K17 A;  2O1U A;  4DR1 I;  4B3T E;  4JI1 I;  4IZJ A;  1XNR E;  2A2D A;  2UUA E;  4B3M I;  4N3O A;  4P7A A;  4Z7Y A;  5DNL A;  3P3E A;  4LPF A;  1H72 C;  3B82 A;  1XXE A;  1Y4S A;  4FWD A;  4IZK B;  4JI0 E;  1Z5B A;  4I3H A;  1KVK A;  4IZK A;  4PU9 A;  2HFS A;  4LFB E;  3ZKD A;  2PO1 B;  4JI7 I;  1ZM4 A;  4ISA A;  2PO1 A;  3ZM7 A;  4DV2 I;  2Z5E A;  5C0X D;  1N32 E;  3NZK A;  3U1Y A;  2CG9 A;  3Q1Q A;  1NHI A;  4JYA E;  4DUY I;  1HNZ E;  4QNK A;  3H4L A;  2BM1 A;  1HR0 I;  1FJG E;  1PKP A;  5JEA E;  4LOM A;  1Z5A A;  5A2Q C;  3L7Z A;  2UUC E;  4B3T I;  5ELW A;  4KHP E;  2BR2 A;  1XNR I;  2BA1 D;  3PYF A;  5DRO A;  4LF6 E;  2Z5B B;  4FW3 A;  3PYG A;  1RRE A;  2WNR B;  2JEB B;  3F0N A;  4YY3 I;  5K36 E;  3V2U C;  1NZ0 A;  2PO0 B;  2AJ4 A;  3ZKB A;  1EI1 A;  4JI0 I;  2ZIT A;  4DPT A;  1IBM I;  4B3S E;  1R6L A;  4DUZ E;  2BA1 G;  4LFB I;  3QT6 A;  2NN6 E;  1P42 A;  2GQ0 A;  1N0U A;  3PRY A;  4HYM A;  3U1K A;  2WW4 A;  4OO1 B;  4IFD A;  4DV6 E;  1FKA E;  1N32 I;  2Z5C A;  4FN5 A;  1XMQ E;  1S16 A;  3WU5 A;  1OYP A;  3LTO A;  4GQU A;  4OO1 A;  4DR5 E;  4JV5 E;  4JYA I;  2C39 B;  1Z0V A;  2UUB E;  2HK3 A;  1NHJ A;  1B62 A;  2WP8 A;  4DU7 A;  3WU4 A;  1FJG I;  2PO2 B;  3D4J A;  2C39 A;  2DEI A;  4AID A;  5BR8 E;  2UUC I;  4RPF A;  5JEA C;  5JEA D;  3T1Y E;  1OJ4 A;  2PO2 A;  4KHP I;  3B8H A;  4LCF A;  1Z5C A;  4LF6 I;  4U3D A;  2J65 A;  2V2V A;  1QZR A;  5DRQ A;  3P06 A;  1FWL A;  5IT9 C;  3PS3 A;  3ZZU A;  4P52 A;  4DPY A;  3B4T A;  4LCH A;  2C38 A;  2VF3 A;  2HKE A;  5K36 C;  5K36 D;  1N33 E;  3V5R A;  3DD6 A;  2VQF E;  4DV5 E;  1J5E I;  1I94 I;  4DV3 I;  2BA0 D;  4BA2 B;  4JI5 E;  1UDQ A;  4DUZ I;  4DR4 E;  1R6M A;  4X62 E;  4JI2 E;  4DV1 E;  1B63 A;  2ZM6 E;  4DPW A;  2NN6 C;  2NN6 D;  1PVG A;  4ZVI A;  4DU8 A;  5LMN E;  4USM A;  4DV6 I;  4DV4 E;  3K85 A;  3UHM A;  5FLX Q;  1XNQ E;  1E3P A;  4DR5 I;  1KTV A;  4JV5 I;  2CVE A;  2UUB I;  3J80 C;  2F1D A;  2BA0 G;  4JI6 E;  4X65 E;  5C0X A;  4FWH A;  5FWK A;  2OI2 A;  3J7A G;  2ZBK B;  4DR7 E;  5L3J A;  1VI7 A;  1YHC A;  2HK2 A;  1IBL E;  2O1T A;  4URL A;  3GLL A;  2V34 A;  5JEA F;  4JI3 E;  1H73 A;  3HKM A;  2R3V A;  1N34 E;  1NHH A;  4DR3 E;  4M1K A;  1XHK A;  2VQF I;  1XMO E;  4WUC A;  4AQY E;  4NXN E;  2O1V A;  2JE6 A;  4JI5 I;  5GMD A;  1A6F A;  5EL9 A;  2J7K A;  4B3R E;  4X62 I;  3L7Z B;  4JI2 I;  4DR4 I;  4IZJ D;  4OKG A;  3LNU A;  2UU9 E;  2BR2 B;  2ZM6 I;  2XEX A;  5K36 F;  3M6A A;  2NPF A;  1UDO A;  3HJC A;  1Z0B A;  1OYR A;  4MU4 A;  5LMN I;  3HUL A;  3LPS A;  4DV4 I;  2UUA I;  3M85 D;  1XNQ I;  4YHH E;  4JG4 A;  4IS9 A;  4DV0 E;  2NN6 F;  4DR6 E;  4JI6 I;  2A2C A;  1Z0G A;  1K47 A;  4OZE A;  4DV7 E;  4LFC E;  2HFU A;  5DNX A;  4DR7 I;  2GS8 A;  5DRR A;  1ZXN A;  2E5L E;  4Z7C A;  2JT2 A;  2HKJ A;  4WUB A;  1N0V C;  4GKK E;  2IOP A;  3JAM Q;  1IBL I;  4WUD A;  3GCM A;  1PIE A;  4IFD B;  4OO1 E;  4MU0 A;  4U3B A;  2Z5C B;  1RR9 A;  1N34 I;  5IWA E;  3J81 Q;  3T1H E;  4LF4 E;  1KIJ A;  1XMO I;  4MDT A;  4AQY I;  2GO3 A;  3QT8 A;  4NXN I;  2WP8 B;  4LFA E;  1HNZ I;  1HNW E;  2DEJ A;  1UDS A;  1U2R A;  4B3R I;  1FWK A;  2BV3 A;  1FI4 A;  2O3Z A;  2IOQ A;  4LF7 E;  5LL6 R;  4DXL A;  1EA6 A;  4FW9 A;  1H7S A;  2X36 A;  4JI1 E;  4YHH I;  2F4V E;  2C38 B;  2CZ9 A;  4HY1 A;  4DV0 I;  4LF5 E;  4UT4 A;  2VES A;  2PNL A;  4QNJ A;  1UEK A;  1BKN A;  1Y5Y A;  4MYT A;  2E5L I;  4NXM E;  4GKK I;  3WU3 A;  3WU6 A;  4B3S I;  4KQV A;  3P3G A;  4JI4 E;  3J7A M;  4MYU A;  4IFD C;  2PNZ A;  4EMD A;  1Z0W A;  3CDJ A;  1DAR A;  3QT5 A;  4HAC A;  4JI7 E;  4OO1 C;  4OO1 D;  2V8P A;  3T1H I;  4LF4 I;  1HK7 A;  5C0X E;  1XMQ I;  4LFA I;  5C0X B;  1IBK E;  3B78 A;  3CWV A;  1WUU A;  4R1F A;  2HHH E;  5A2Q Q;  5BR8 I;  3KRN A;  4LF7 I;  2C37 A;  3T1Y I;  1VIS A;  2IES A;  2AE8 A;  1UDN A;  4AIM A;  2F4V I;  2BM0 A;  4LF8 E;  4LF5 I;  2GO4 A;  2VQE E;  2O1W A;  4J3D A;  4YY3 E;  4OX9 E;  2X7I A;  1USU A;  1N33 I;  2JE6 B;  4DV5 I;  1H7U A; 
#chains in the Genus database with same CATH homology
 4FW6 A;  4OZE A;  4FW4 A;  3PS1 A;  1XXE A;  3PS2 A;  2IER A;  5DRR A;  2O3Z A;  2JT2 A;  3P3G A;  4OKG A;  2IES A;  4LCF A;  4LCG A;  1P42 A;  1YHC A;  4U3D A;  5DRO A;  2J65 A;  3P76 A;  4FW7 A;  5DRQ A;  4ISA A;  3PS3 A;  4FW3 A;  4U3B A;  2GO4 A;  3UHM A;  5DRP A;  4J3D A;  4MQY A;  4IS9 A;  4LCH A;  2VES A;  4FW5 A;  4MDT A;  3NZK A;  2GO3 A;  1YH8 A;  3P3C A;  3U1Y A;  3P3E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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