1YHCA

Crystal structure of aquifex aeolicus lpxc deacetylase complexed with cacodylate
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
266
structure length
266
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 91
structure length 266
sequence length 266
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2005-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 1yhcA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 1yhcA02
1P42A 1YH8A 2IERA 5DROA 2JT2A 3U1YA 4FW3A 4LCGA 4IS9A 3PS1A 4U3DA 1XXEA 3PS3A 5DRRA 2VESA 2IESA 4LCFA 3P3EA 2GO3A 1YHCA 3P3GA 3UHMA 4J3DA 4FW6A 5DRPA 2O3ZA 4FW4A 2J65A 4OKGA 4OZEA 4MDTA 3PS2A 3P3CA 4LCHA 4U3BA 3P76A 4FW7A 4MQYA 5DRQA 3NZKA 4FW5A 2GO4A 4ISAA
chains in the Genus database with same CATH superfamily
4FN5A 2JT2A 2JE6A 3CDJA 4LF4I 4NXME 1KIJA 4IFDB 5FLXC 1HNXE 2V8PA 1PKPA 4IZKB 2E5LE 4LF6I 2GO3A 4DUYE 4QNKA 1B62A 4MYUA 2UXDI 3M6AA 4MU1A 4OO1D 5DRPA 4JV5E 1XHKA 4YY3E 4KHPI 4JI7E 2E1RA 3WU3A 1S16A 1Y4SA 4MYTA 4X62I 5BR8I 4B3MI 1PVGA 4DR6I 4EMDA 2UXCE 2BA0G 1S4EA 3LTOA 4K0KE 2V34A 2IERA 4PRVA 4DV2I 4DR1E 1N33E 4PRXA 3U1YA 1H7SA 4LF8I 1XMQE 2O1VA 4FWGA 4ZVIA 1RR9A 1ELOA 1ZXNA 1FWKA 4IFDE 2BV3A 2C39A 3J7AM 1IBLI 1HNWE 2PNMA 1IBMI 3PYFA 2JEBA 4OZEA 4MDTA 1J5EI 4YHHI 4JI2I 4X65I 3PRYA 1Z0WA 5JEAE 4U3BA 1XNQI 1MG7A 4B3RE 2VQFE 3WU5A 4LF7E 1B63A 4X64E 3M85G 3H4LA 5JEAC 2PNZB 2UUCE 1XNRE 2PO1A 5K36D 1N34I 5EL9A 4DV6I 5GMDA 5IWAE 1H74A 3B82A 4PU9A 2HHHI 2AE8A 2BM1A 4LFAI 1Y6ZA 4JI6E 4X66I 2NN6A 4MU0A 1NHHA 4DR7E 1N32I 4DV4E 4DPWA 4LFBI 1FJGI 3U1KA 2A2DA 2WP8A 2Z5EA 4DXLA 4DV0E 2Z5CB 4LF5E 4FW4A 2C38A 4DV7I 2JEAB 1Z59A 3ZKBA 4JI1I 2VQEI 3Q6NA 3P3CA 3CWVA 3QT7A 3PYGA 3HJCA 4B3SE 4R1FA 4HXZA 1OYSA 5DROA 4WUCA 5GMEA 4JI3E 5LMUI 2CVEA 4LFCE 1FNMA 1Z5CA 4IZJA 1Z0EA 3T1YE 1NHJA 1Z0VA 2BR2B 4HACA 2PO2B 2UUAI 4LF6E 1UDNA 2WNRB 1I94E 4NXNE 2OI2A 1KTVA 1HNZI 3V5RA 5JEAD 2F4VE 4MU4A 1Z0CA 5C0XA 4X62E 4LPFA 4B3ME 4OO1A 4JI8I 5DRRA 1HR0I 4GKKE 4DUZI 4DV2E 4LF8E 3GMEA 4ED4A 4OX9E 3J7AG 3KRNA 3QT5A 4GKJE 1RHYA 2NPFA 3GCMA 1FWLA 3PS2A 5JEAB 1IBLE 4B3TE 1IBME 4AIDA 2X36A 2LJPA 5LL6R 2PO0B 1OJ4A 3OTOE 2UXBI 1YH8A 4DU7A 1Z5BA 1J5EE 2UUBI 2ZM6I 4YHHE 4X65E 4AM3A 4URLA 3GLLA 1XNQE 3P3EA 1H73A 1UDOA 4DV5I 3T1HI 3H1CA 2V2ZA 4DR4I 3QT6A 2NN6C 2AJ4A 4I3HA 2BA0D 4KQVA 2VF3A 2C37B 4NXMI 2BA1G 1N34E 1DARA 4DV6E 4BA1B 4BA2A 2HHHE 4DUYI 5K36A 2R42A 5DNXA 5FWKA 4JV5I 2JE6B 2F1DA 1NHIA 4YY3I 1RREA 1KVKA 4AIMA 4DV3I 1N0VC 4J3DA 1E3HA 2UXCI 1N36E 4DR1I 4RPFA 1XMQI 3LPSA 4JI4E 1KKHA 1USVA 2ZBKB 3L7ZA 4FWDA 1NZ0A 3NZKA 1EI1A 3M85D 1P42A 4USKA 4LF9E 1Z5AA 4DR5I 3M7NG 2NN6F 4GQUA 3CDIA 4Z7CA 2Z5BA 2ZITA 4FWHA 4HY1A 4P52A 4USMA 3K17A 3JAMQ 2C39B 2J65A 1IBKE 5LMNI 1FKAE 2V2VA 2VQFI 2JEBB 5C0XC 1XMOI 2V2QA 1VISA 4UTGA 4JI0I 4OO1C 3P76A 2BM0A 1ZM3A 4MQYA 5DRQA 4FW6A 3GONA 2DEIA 4IFDA 1XNRI 1OYRA 4FW3A 4DU8A 2O1WA 4IZKA 4IFDF 3JAMC 2CG9A 4DV1I 3ZZUA 1R6MA 1Y4UA 2NN6D 1BKNA 1E3PA 4DR3I 2HK3A 1ZXMA 4LF4E 1ZM4A 4JI8E 1HR0E 4JI6I 2PO1B 1PIEA 2HK2A 4AQYI 4DR7I 4DV4I 3ZZ0A 5ELWA 2IOQA 2IOPA 4DR2I 2UXDE 1R6LA 4ISAA 4MU3A 4JG4A 4KHPE 2NN6B 3LNUA 5BR8E 4DR6E 4LF5I 5C0XF 3Q6MA 4OO1F 4DPYA 3DD6A 3UHMA 2O1UA 2WP8B 4FW9A 2Q2EB 4IZJD 4OKGA 2WW4A 4DV5E 3WU4A 2A2CA 3ZM7A 5A2QQ 5K36C 4DR4E 2C38B 1UEKA 4JYAI 4LFCI 4N3OA 3HULA 3HKMA 2GO4A 3T1YI 3QT8A 2HFSA 5IT9Q 4JI2E 1N0UA 4WUDA 2PNZA 4XTJA 1WUUA 1XXEA 2X7IA 3ZKDA 4JI5I 1H72C 2NN6E 1I94I 2UU9I 4NXNI 1YHCA 5A2QC 5C0XD 4IZJB 2J7KA 2PNLA 1QZRA 4NBQA 2F4VI 4HACB 4DV3E 3B78A 5IT9C 4FW5A 1VI7A 4FW7A 5L3JA 4GKKI 1HNXI 1Z0TA 2HKEA 2E5LI 4OX9I 1FI4A 2CZ9A 3K85A 4GKJI 4LFAE 3PS3A 5C0XB 5EKWA 5K36F 2Z5CA 3P06A 1USUA 3B8HA 4X66E 4OO1B 1H7UA 4B3TI 4DR5E 4JI7I 1N32E 2JEAA 3OTOI 2BA1D 4LFBE 1FJGE 4K0KI 4IFDC 1N33I 4UT4A 1Z0GA 5LMNE 4DV7E 2VQEE 1XMOE 2DEJA 4JI1E 4JI0E 3D4JA 4IS9A 1HNWI 4U3DA 1Y5YA 2BR2A 2VESA 4QNJA 3Q1QA 2PO2A 4M1KA 4LOMA 5C0XE 4OO1E 5LMUE 3J80Q 3PYDA 2WNRA 4DV1E 1Z0BA 4DR3E 4B3RI 4LCHA 2EFGA 3V2UC 4LF7I 3B4TA 4X64I 2HKJA 4Z7YA 2UUAE 3M7ND 1MU5A 4AQYE 4BA2B 2UUCI 1HNZE 3PS1A 4DR2E 2GS8A 1N36I 3J80C 5K36B 2IESA 4DPUA 5IWAI 1A6FA 4JI4I 2GQ0A 1U2RA 1MX0A 5JEAA 2O3ZA 2CGEA 4DPTA 4DUZE 1EA6A 4LF9I 5JEAF 2PO0A 1UDQA 2HFUA 4HYMA 1UDSA 2O1TA 3PYEA 3L7ZB 4JYAE 4LCGA 3J81Q 4DV0I 1IBKI 3F0NA 4LCFA 2UXBE 1ZM2A 4WUBA 2ZM6E 2UUBE 4IFDD 3K1JA 5K36E 3ZZTA 2R3VA 2Z5BB 3P3GA 5FLXQ 4JI5E 1K47A 4DPXA 1HK7A 2C37A 4B3SI 1OYPA 1D6TA 1ZM9A 2UU9E 4BA1A 3T1HE 4JI3I 2XEXA 3WU6A 3J81C 1Y60A 4P7AA 5DNLA
chains in the Genus database with same CATH topology
1P42A 1YH8A 2IERA 5DROA 2JT2A 3U1YA 4FW3A 4LCGA 4IS9A 3PS1A 4U3DA 1XXEA 3PS3A 5DRRA 2VESA 2IESA 4LCFA 3P3EA 2GO3A 1YHCA 3P3GA 3UHMA 4J3DA 4FW6A 5DRPA 2O3ZA 4FW4A 2J65A 4OKGA 4OZEA 4MDTA 3PS2A 3P3CA 4LCHA 4U3BA 3P76A 4FW7A 4MQYA 5DRQA 3NZKA 4FW5A 2GO4A 4ISAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P42 A;  1YH8 A;  2IER A;  5DRO A;  2JT2 A;  3U1Y A;  4FW3 A;  4LCG A;  4IS9 A;  3PS1 A;  4U3D A;  1XXE A;  3PS3 A;  5DRR A;  2VES A;  2IES A;  4LCF A;  3P3E A;  2GO3 A;  1YHC A;  3P3G A;  3UHM A;  4J3D A;  4FW6 A;  5DRP A;  2O3Z A;  4FW4 A;  2J65 A;  4OKG A;  4OZE A;  4MDT A;  3PS2 A;  3P3C A;  4LCH A;  4U3B A;  3P76 A;  4FW7 A;  4MQY A;  5DRQ A;  3NZK A;  4FW5 A;  2GO4 A;  4ISA A; 
#chains in the Genus database with same CATH topology
 4FN5 A;  2JT2 A;  2JE6 A;  3CDJ A;  4LF4 I;  4NXM E;  1KIJ A;  4IFD B;  5FLX C;  1HNX E;  2V8P A;  1PKP A;  4IZK B;  2E5L E;  4LF6 I;  2GO3 A;  4DUY E;  4QNK A;  1B62 A;  4MYU A;  2UXD I;  3M6A A;  4MU1 A;  4OO1 D;  5DRP A;  4JV5 E;  1XHK A;  4YY3 E;  4KHP I;  4JI7 E;  2E1R A;  3WU3 A;  1S16 A;  1Y4S A;  4MYT A;  4X62 I;  5BR8 I;  4B3M I;  1PVG A;  4DR6 I;  4EMD A;  2UXC E;  2BA0 G;  1S4E A;  3LTO A;  4K0K E;  2V34 A;  2IER A;  4PRV A;  4DV2 I;  4DR1 E;  1N33 E;  4PRX A;  3U1Y A;  1H7S A;  4LF8 I;  1XMQ E;  2O1V A;  4FWG A;  4ZVI A;  1RR9 A;  1ELO A;  1ZXN A;  1FWK A;  4IFD E;  2BV3 A;  2C39 A;  3J7A M;  1IBL I;  1HNW E;  2PNM A;  1IBM I;  3PYF A;  2JEB A;  4OZE A;  4MDT A;  1J5E I;  4YHH I;  4JI2 I;  4X65 I;  3PRY A;  1Z0W A;  5JEA E;  4U3B A;  1XNQ I;  1MG7 A;  4B3R E;  2VQF E;  3WU5 A;  4LF7 E;  1B63 A;  4X64 E;  3M85 G;  3H4L A;  5JEA C;  2PNZ B;  2UUC E;  1XNR E;  2PO1 A;  5K36 D;  1N34 I;  5EL9 A;  4DV6 I;  5GMD A;  5IWA E;  1H74 A;  3B82 A;  4PU9 A;  2HHH I;  2AE8 A;  2BM1 A;  4LFA I;  1Y6Z A;  4JI6 E;  4X66 I;  2NN6 A;  4MU0 A;  1NHH A;  4DR7 E;  1N32 I;  4DV4 E;  4DPW A;  4LFB I;  1FJG I;  3U1K A;  2A2D A;  2WP8 A;  2Z5E A;  4DXL A;  4DV0 E;  2Z5C B;  4LF5 E;  4FW4 A;  2C38 A;  4DV7 I;  2JEA B;  1Z59 A;  3ZKB A;  4JI1 I;  2VQE I;  3Q6N A;  3P3C A;  3CWV A;  3QT7 A;  3PYG A;  3HJC A;  4B3S E;  4R1F A;  4HXZ A;  1OYS A;  5DRO A;  4WUC A;  5GME A;  4JI3 E;  5LMU I;  2CVE A;  4LFC E;  1FNM A;  1Z5C A;  4IZJ A;  1Z0E A;  3T1Y E;  1NHJ A;  1Z0V A;  2BR2 B;  4HAC A;  2PO2 B;  2UUA I;  4LF6 E;  1UDN A;  2WNR B;  1I94 E;  4NXN E;  2OI2 A;  1KTV A;  1HNZ I;  3V5R A;  5JEA D;  2F4V E;  4MU4 A;  1Z0C A;  5C0X A;  4X62 E;  4LPF A;  4B3M E;  4OO1 A;  4JI8 I;  5DRR A;  1HR0 I;  4GKK E;  4DUZ I;  4DV2 E;  4LF8 E;  3GME A;  4ED4 A;  4OX9 E;  3J7A G;  3KRN A;  3QT5 A;  4GKJ E;  1RHY A;  2NPF A;  3GCM A;  1FWL A;  3PS2 A;  5JEA B;  1IBL E;  4B3T E;  1IBM E;  4AID A;  2X36 A;  2LJP A;  5LL6 R;  2PO0 B;  1OJ4 A;  3OTO E;  2UXB I;  1YH8 A;  4DU7 A;  1Z5B A;  1J5E E;  2UUB I;  2ZM6 I;  4YHH E;  4X65 E;  4AM3 A;  4URL A;  3GLL A;  1XNQ E;  3P3E A;  1H73 A;  1UDO A;  4DV5 I;  3T1H I;  3H1C A;  2V2Z A;  4DR4 I;  3QT6 A;  2NN6 C;  2AJ4 A;  4I3H A;  2BA0 D;  4KQV A;  2VF3 A;  2C37 B;  4NXM I;  2BA1 G;  1N34 E;  1DAR A;  4DV6 E;  4BA1 B;  4BA2 A;  2HHH E;  4DUY I;  5K36 A;  2R42 A;  5DNX A;  5FWK A;  4JV5 I;  2JE6 B;  2F1D A;  1NHI A;  4YY3 I;  1RRE A;  1KVK A;  4AIM A;  4DV3 I;  1N0V C;  4J3D A;  1E3H A;  2UXC I;  1N36 E;  4DR1 I;  4RPF A;  1XMQ I;  3LPS A;  4JI4 E;  1KKH A;  1USV A;  2ZBK B;  3L7Z A;  4FWD A;  1NZ0 A;  3NZK A;  1EI1 A;  3M85 D;  1P42 A;  4USK A;  4LF9 E;  1Z5A A;  4DR5 I;  3M7N G;  2NN6 F;  4GQU A;  3CDI A;  4Z7C A;  2Z5B A;  2ZIT A;  4FWH A;  4HY1 A;  4P52 A;  4USM A;  3K17 A;  3JAM Q;  2C39 B;  2J65 A;  1IBK E;  5LMN I;  1FKA E;  2V2V A;  2VQF I;  2JEB B;  5C0X C;  1XMO I;  2V2Q A;  1VIS A;  4UTG A;  4JI0 I;  4OO1 C;  3P76 A;  2BM0 A;  1ZM3 A;  4MQY A;  5DRQ A;  4FW6 A;  3GON A;  2DEI A;  4IFD A;  1XNR I;  1OYR A;  4FW3 A;  4DU8 A;  2O1W A;  4IZK A;  4IFD F;  3JAM C;  2CG9 A;  4DV1 I;  3ZZU A;  1R6M A;  1Y4U A;  2NN6 D;  1BKN A;  1E3P A;  4DR3 I;  2HK3 A;  1ZXM A;  4LF4 E;  1ZM4 A;  4JI8 E;  1HR0 E;  4JI6 I;  2PO1 B;  1PIE A;  2HK2 A;  4AQY I;  4DR7 I;  4DV4 I;  3ZZ0 A;  5ELW A;  2IOQ A;  2IOP A;  4DR2 I;  2UXD E;  1R6L A;  4ISA A;  4MU3 A;  4JG4 A;  4KHP E;  2NN6 B;  3LNU A;  5BR8 E;  4DR6 E;  4LF5 I;  5C0X F;  3Q6M A;  4OO1 F;  4DPY A;  3DD6 A;  3UHM A;  2O1U A;  2WP8 B;  4FW9 A;  2Q2E B;  4IZJ D;  4OKG A;  2WW4 A;  4DV5 E;  3WU4 A;  2A2C A;  3ZM7 A;  5A2Q Q;  5K36 C;  4DR4 E;  2C38 B;  1UEK A;  4JYA I;  4LFC I;  4N3O A;  3HUL A;  3HKM A;  2GO4 A;  3T1Y I;  3QT8 A;  2HFS A;  5IT9 Q;  4JI2 E;  1N0U A;  4WUD A;  2PNZ A;  4XTJ A;  1WUU A;  1XXE A;  2X7I A;  3ZKD A;  4JI5 I;  1H72 C;  2NN6 E;  1I94 I;  2UU9 I;  4NXN I;  1YHC A;  5A2Q C;  5C0X D;  4IZJ B;  2J7K A;  2PNL A;  1QZR A;  4NBQ A;  2F4V I;  4HAC B;  4DV3 E;  3B78 A;  5IT9 C;  4FW5 A;  1VI7 A;  4FW7 A;  5L3J A;  4GKK I;  1HNX I;  1Z0T A;  2HKE A;  2E5L I;  4OX9 I;  1FI4 A;  2CZ9 A;  3K85 A;  4GKJ I;  4LFA E;  3PS3 A;  5C0X B;  5EKW A;  5K36 F;  2Z5C A;  3P06 A;  1USU A;  3B8H A;  4X66 E;  4OO1 B;  1H7U A;  4B3T I;  4DR5 E;  4JI7 I;  1N32 E;  2JEA A;  3OTO I;  2BA1 D;  4LFB E;  1FJG E;  4K0K I;  4IFD C;  1N33 I;  4UT4 A;  1Z0G A;  5LMN E;  4DV7 E;  2VQE E;  1XMO E;  2DEJ A;  4JI1 E;  4JI0 E;  3D4J A;  4IS9 A;  1HNW I;  4U3D A;  1Y5Y A;  2BR2 A;  2VES A;  4QNJ A;  3Q1Q A;  2PO2 A;  4M1K A;  4LOM A;  5C0X E;  4OO1 E;  5LMU E;  3J80 Q;  3PYD A;  2WNR A;  4DV1 E;  1Z0B A;  4DR3 E;  4B3R I;  4LCH A;  2EFG A;  3V2U C;  4LF7 I;  3B4T A;  4X64 I;  2HKJ A;  4Z7Y A;  2UUA E;  3M7N D;  1MU5 A;  4AQY E;  4BA2 B;  2UUC I;  1HNZ E;  3PS1 A;  4DR2 E;  2GS8 A;  1N36 I;  3J80 C;  5K36 B;  2IES A;  4DPU A;  5IWA I;  1A6F A;  4JI4 I;  2GQ0 A;  1U2R A;  1MX0 A;  5JEA A;  2O3Z A;  2CGE A;  4DPT A;  4DUZ E;  1EA6 A;  4LF9 I;  5JEA F;  2PO0 A;  1UDQ A;  2HFU A;  4HYM A;  1UDS A;  2O1T A;  3PYE A;  3L7Z B;  4JYA E;  4LCG A;  3J81 Q;  4DV0 I;  1IBK I;  3F0N A;  4LCF A;  2UXB E;  1ZM2 A;  4WUB A;  2ZM6 E;  2UUB E;  4IFD D;  3K1J A;  5K36 E;  3ZZT A;  2R3V A;  2Z5B B;  3P3G A;  5FLX Q;  4JI5 E;  1K47 A;  4DPX A;  1HK7 A;  2C37 A;  4B3S I;  1OYP A;  1D6T A;  1ZM9 A;  2UU9 E;  4BA1 A;  3T1H E;  4JI3 I;  2XEX A;  3WU6 A;  3J81 C;  1Y60 A;  4P7A A;  5DNL A; 
#chains in the Genus database with same CATH homology
 1P42 A;  1YH8 A;  2IER A;  5DRO A;  2JT2 A;  3U1Y A;  4FW3 A;  4LCG A;  4IS9 A;  3PS1 A;  4U3D A;  1XXE A;  3PS3 A;  5DRR A;  2VES A;  2IES A;  4LCF A;  3P3E A;  2GO3 A;  1YHC A;  3P3G A;  3UHM A;  4J3D A;  4FW6 A;  5DRP A;  2O3Z A;  4FW4 A;  2J65 A;  4OKG A;  4OZE A;  4MDT A;  3PS2 A;  3P3C A;  4LCH A;  4U3B A;  3P76 A;  4FW7 A;  4MQY A;  5DRQ A;  3NZK A;  4FW5 A;  2GO4 A;  4ISA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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