2GO4A

Crystal structure of aquifex aeolicus lpxc complexed with tu-514
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
266
structure length
266
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 88
structure length 266
sequence length 266
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2006-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2go4A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2go4A02
4MDTA 4FW3A 4FW7A 3U1YA 1XXEA 2GO3A 4J3DA 3PS3A 5DROA 5DRRA 2GO4A 2IESA 1YHCA 3UHMA 2IERA 3P3CA 3PS1A 4U3BA 4IS9A 3P76A 4LCGA 3NZKA 4OZEA 5DRPA 2J65A 2VESA 4LCHA 3P3GA 4MQYA 4LCFA 4FW4A 5DRQA 3P3EA 1P42A 4FW6A 3PS2A 4ISAA 1YH8A 2O3ZA 4U3DA 4FW5A 4OKGA 2JT2A
chains in the Genus database with same CATH superfamily
2PO0A 2PNZB 4ED4A 1S4EA 1Z0CA 4YY3E 1FKAE 3H1CA 2BA0D 1N36I 3V5RA 1PKPA 2E5LI 2ZBKB 2JEBB 4DV0I 1XNRI 4DV4E 1XMQI 2XEXA 5K36D 3M85D 4LCFA 5DRQA 4YHHI 4MU3A 4IZJB 3ZZTA 1KVKA 1E3PA 4DV3E 4RPFA 4LFBE 2WW4A 1VI7A 2NN6D 1OJ4A 4JI6E 4KHPI 4B3SI 4DPUA 4IFDC 2GO4A 1BKNA 3UHMA 3M7ND 2F1DA 1EI1A 4DPTA 4IFDB 3PYFA 4URLA 3NZKA 3P3EA 4DR5E 1HR0I 1Z0EA 2V34A 4U3DA 2BA1G 3J7AG 2HFSA 1Z5BA 1FJGI 4X64I 2GO3A 5FWKA 4DR3E 5IWAI 4DV1E 4WUCA 2HK2A 2DEIA 2Z5BB 3PS1A 1MG7A 3WU6A 4JV5E 4LF8E 5K36B 1VISA 1Z0TA 4I3HA 2J7KA 1N32E 4QNJA 3M85G 4MQYA 4JI5I 2JE6B 2LJPA 2ZM6E 4BA1A 1DARA 1UDSA 4FWGA 2NN6B 3OTOI 4FW5A 1H72C 1NZ0A 2JT2A 4MDTA 4DR4E 4DV6E 2HHHI 4OO1D 5C0XD 4X66I 1FWLA 5DROA 2UXCI 1FWKA 4B3ME 1N33E 4JI4E 2JEAB 4DUZI 4LF5E 4LCHA 3L7ZA 3T1YI 4JI0E 4LFAE 1ELOA 4DPWA 5LMUE 4ISAA 4DR7E 4DV5I 3LPSA 4PU9A 1UDQA 1J5EE 2HK3A 4HACA 4DR1I 4LPFA 5BR8I 3JAMQ 1XNQI 1OYSA 2PO2A 4AIMA 4U3BA 1UDOA 4DV2I 1HNWE 1B63A 5DNXA 4DR6E 1USVA 5IT9Q 1IBLI 3P3GA 5JEAC 2UXBI 2O1TA 2X36A 2WNRB 4LF4I 3J7AM 2O1WA 5JEAB 4X62I 4OO1B 5C0XB 4NXNI 4DR2E 4JI7E 2C38A 4DUYE 4LF9I 1MU5A 1ZM9A 4LF6E 2AJ4A 3H4LA 2UU9E 4J3DA 2EFGA 3WU5A 4BA2B 4JYAE 4DU7A 4EMDA 1S16A 4JI2I 2Z5CB 4IS9A 3DD6A 2CG9A 1IBKE 2PO0B 1H73A 2A2DA 2V2VA 4Z7CA 4JI8I 4JI1I 2UUAI 3GONA 4OX9I 4IZKA 1N36E 4GKJI 3K85A 2IOQA 4MU1A 1Z59A 5EKWA 4DV3I 4LFCI 3KRNA 1ZM3A 2E5LE 4MU0A 4DV0E 1PVGA 1YHCA 3PYEA 1XMQE 4YHHE 1EA6A 3PYGA 3HJCA 2VQFI 4IFDF 1UEKA 2NPFA 4FW9A 2VESA 3P06A 3T1HI 4R1FA 4FW6A 1KIJA 2BR2A 4B3SE 1Z0WA 3U1KA 1N34I 5FLXQ 4UT4A 2AE8A 5K36C 2BA0G 1U2RA 4PRXA 4B3TI 4LF7E 1HR0E 2C37A 2WP8A 2C39A 4K0KE 1NHJA 4USMA 3M6AA 1N0UA 3V2UC 2CVEA 2NN6C 5FLXC 2R3VA 1FJGE 2UUCI 4X64E 5IWAE 2R42A 1I94I 1ZXMA 4MYUA 3QT7A 4JI3E 1FI4A 5LMNI 3HULA 2UUBE 2HKEA 3PS3A 3M7NG 1HNZI 4BA1B 1H74A 1H7UA 3LNUA 2ZITA 3OTOE 2PNMA 2VF3A 1Y5YA 5EL9A 4LF5I 4X66E 2O3ZA 1XMOI 2F4VI 1OYPA 2GQ0A 4GKKI 2UXCE 4X65I 5LMUI 2PNLA 3J81Q 4DXLA 4DUZE 4ZVIA 2CZ9A 1J5EI 4DPYA 3L7ZB 1B62A 2IERA 3T1YE 4MYTA 4IFDE 4HY1A 4LCGA 1USUA 4OZEA 4DV5E 1PIEA 4FW4A 4HACB 3J81C 4DV7I 4NXME 4DR1E 4NBQA 2GS8A 4OO1C 5C0XC 3K17A 3JAMC 4B3RI 5BR8E 3K1JA 2HKJA 3GMEA 1HNXI 4DPXA 1KKHA 3B82A 5JEAF 2PO2B 1XNQE 4FW3A 2PO1A 2VQEI 4DV2E 1Z5CA 5IT9C 4AM3A 4AIDA 1IBMI 2DEJA 3QT5A 1HK7A 3D4JA 1IBLE 4FWDA 5K36E 2UXBE 2E1RA 2PNZA 4YY3I 3ZZUA 4LF4E 1N0VC 4X62E 2C38B 2UXDE 4NXNE 2PO1B 4DU8A 4AQYE 4LF9E 2NN6E 3LTOA 2JEBA 1Y6ZA 4LOMA 4DV4I 4WUBA 2BA1D 1RHYA 1Y4SA 4JI2E 3U1YA 1XXEA 4IZJA 1A6FA 3B78A 3GLLA 4FWHA 3PYDA 1ZXNA 3QT6A 4AQYI 2OI2A 4LFBI 2IESA 4UTGA 1XNRE 2BV3A 4HXZA 1Z0GA 4JI6I 4JI8E 4Z7YA 4M1KA 2UUAE 4JI1E 4IZKB 4QNKA 4OX9E 5GMDA 4GKJE 3GCMA 4IFDA 4LFCE 4KHPE 2V8PA 4PRVA 1NHHA 4FW7A 4DR5I 4P52A 2VQFE 1FNMA 2HFUA 4FN5A 3P3CA 1XHKA 3T1HE 4DR3I 1D6TA 4DV1I 2BR2B 5K36F 1ZM4A 4JV5I 4LF7I 2Z5BA 4LF8I 5K36A 4K0KI 5JEAE 4OO1E 1N32I 5C0XE 1MX0A 1N34E 2V2ZA 1QZRA 4OKGA 3PRYA 2JE6A 3J80Q 2NN6F 2ZM6I 4B3TE 2CGEA 2C37B 1RREA 2C39B 2WP8B 2IOPA 2NN6A 4JI3I 1OYRA 5DRRA 4P7AA 2UUBI 5GMEA 4DR4I 4JI5E 4DV6I 2UUCE 3J80C 2Z5EA 3ZKDA 4B3MI 1I94E 5ELWA 1Y4UA 5LMNE 1N33I 4GQUA 1K47A 4JI4I 3Q1QA 3WU3A 1R6MA 2HHHE 2JEAA 1YH8A 1RR9A 4LFAI 4JI0I 1HNZE 4HYMA 5JEAD 1E3HA 5L3JA 4DR7I 3CDJA 1Z0BA 1Z0VA 3F0NA 2Q2EB 1UDNA 1WUUA 1Z5AA 5DNLA 4MU4A 3QT8A 3Q6MA 5DRPA 2J65A 1XMOE 2F4VE 4GKKE 4X65E 1Y60A 1P42A 1HNWI 4DR6I 1R6LA 4IZJD 4NXMI 4OO1F 1KTVA 2WNRA 4WUDA 3ZM7A 5C0XF 5A2QQ 2A2CA 2O1UA 1H7SA 5JEAA 1NHIA 4OO1A 3ZZ0A 5C0XA 4DR2I 4JI7I 4N3OA 3CWVA 4DUYI 4LF6I 4DV7E 3ZKBA 2BM0A 2UU9I 2X7IA 3WU4A 4B3RE 3P76A 4JYAI 4BA2A 1HNXE 2V2QA 5LL6R 5A2QC 4IFDD 3Q6NA 2Z5CA 4USKA 3CDIA 2VQEE 3PS2A 1ZM2A 2BM1A 4JG4A 2UXDI 2O1VA 1IBKI 4XTJA 1IBME 3HKMA 4KQVA 3B4TA 3B8HA
chains in the Genus database with same CATH topology
4MDTA 4FW3A 4FW7A 3U1YA 1XXEA 2GO3A 4J3DA 3PS3A 5DROA 5DRRA 2GO4A 2IESA 1YHCA 3UHMA 2IERA 3P3CA 3PS1A 4U3BA 4IS9A 3P76A 4LCGA 3NZKA 4OZEA 5DRPA 2J65A 2VESA 4LCHA 3P3GA 4MQYA 4LCFA 4FW4A 5DRQA 3P3EA 1P42A 4FW6A 3PS2A 4ISAA 1YH8A 2O3ZA 4U3DA 4FW5A 4OKGA 2JT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MDT A;  4FW3 A;  4FW7 A;  3U1Y A;  1XXE A;  2GO3 A;  4J3D A;  3PS3 A;  5DRO A;  5DRR A;  2GO4 A;  2IES A;  1YHC A;  3UHM A;  2IER A;  3P3C A;  3PS1 A;  4U3B A;  4IS9 A;  3P76 A;  4LCG A;  3NZK A;  4OZE A;  5DRP A;  2J65 A;  2VES A;  4LCH A;  3P3G A;  4MQY A;  4LCF A;  4FW4 A;  5DRQ A;  3P3E A;  1P42 A;  4FW6 A;  3PS2 A;  4ISA A;  1YH8 A;  2O3Z A;  4U3D A;  4FW5 A;  4OKG A;  2JT2 A; 
#chains in the Genus database with same CATH topology
 2PO0 A;  2PNZ B;  4ED4 A;  1S4E A;  1Z0C A;  4YY3 E;  1FKA E;  3H1C A;  2BA0 D;  1N36 I;  3V5R A;  1PKP A;  2E5L I;  2ZBK B;  2JEB B;  4DV0 I;  1XNR I;  4DV4 E;  1XMQ I;  2XEX A;  5K36 D;  3M85 D;  4LCF A;  5DRQ A;  4YHH I;  4MU3 A;  4IZJ B;  3ZZT A;  1KVK A;  1E3P A;  4DV3 E;  4RPF A;  4LFB E;  2WW4 A;  1VI7 A;  2NN6 D;  1OJ4 A;  4JI6 E;  4KHP I;  4B3S I;  4DPU A;  4IFD C;  2GO4 A;  1BKN A;  3UHM A;  3M7N D;  2F1D A;  1EI1 A;  4DPT A;  4IFD B;  3PYF A;  4URL A;  3NZK A;  3P3E A;  4DR5 E;  1HR0 I;  1Z0E A;  2V34 A;  4U3D A;  2BA1 G;  3J7A G;  2HFS A;  1Z5B A;  1FJG I;  4X64 I;  2GO3 A;  5FWK A;  4DR3 E;  5IWA I;  4DV1 E;  4WUC A;  2HK2 A;  2DEI A;  2Z5B B;  3PS1 A;  1MG7 A;  3WU6 A;  4JV5 E;  4LF8 E;  5K36 B;  1VIS A;  1Z0T A;  4I3H A;  2J7K A;  1N32 E;  4QNJ A;  3M85 G;  4MQY A;  4JI5 I;  2JE6 B;  2LJP A;  2ZM6 E;  4BA1 A;  1DAR A;  1UDS A;  4FWG A;  2NN6 B;  3OTO I;  4FW5 A;  1H72 C;  1NZ0 A;  2JT2 A;  4MDT A;  4DR4 E;  4DV6 E;  2HHH I;  4OO1 D;  5C0X D;  4X66 I;  1FWL A;  5DRO A;  2UXC I;  1FWK A;  4B3M E;  1N33 E;  4JI4 E;  2JEA B;  4DUZ I;  4LF5 E;  4LCH A;  3L7Z A;  3T1Y I;  4JI0 E;  4LFA E;  1ELO A;  4DPW A;  5LMU E;  4ISA A;  4DR7 E;  4DV5 I;  3LPS A;  4PU9 A;  1UDQ A;  1J5E E;  2HK3 A;  4HAC A;  4DR1 I;  4LPF A;  5BR8 I;  3JAM Q;  1XNQ I;  1OYS A;  2PO2 A;  4AIM A;  4U3B A;  1UDO A;  4DV2 I;  1HNW E;  1B63 A;  5DNX A;  4DR6 E;  1USV A;  5IT9 Q;  1IBL I;  3P3G A;  5JEA C;  2UXB I;  2O1T A;  2X36 A;  2WNR B;  4LF4 I;  3J7A M;  2O1W A;  5JEA B;  4X62 I;  4OO1 B;  5C0X B;  4NXN I;  4DR2 E;  4JI7 E;  2C38 A;  4DUY E;  4LF9 I;  1MU5 A;  1ZM9 A;  4LF6 E;  2AJ4 A;  3H4L A;  2UU9 E;  4J3D A;  2EFG A;  3WU5 A;  4BA2 B;  4JYA E;  4DU7 A;  4EMD A;  1S16 A;  4JI2 I;  2Z5C B;  4IS9 A;  3DD6 A;  2CG9 A;  1IBK E;  2PO0 B;  1H73 A;  2A2D A;  2V2V A;  4Z7C A;  4JI8 I;  4JI1 I;  2UUA I;  3GON A;  4OX9 I;  4IZK A;  1N36 E;  4GKJ I;  3K85 A;  2IOQ A;  4MU1 A;  1Z59 A;  5EKW A;  4DV3 I;  4LFC I;  3KRN A;  1ZM3 A;  2E5L E;  4MU0 A;  4DV0 E;  1PVG A;  1YHC A;  3PYE A;  1XMQ E;  4YHH E;  1EA6 A;  3PYG A;  3HJC A;  2VQF I;  4IFD F;  1UEK A;  2NPF A;  4FW9 A;  2VES A;  3P06 A;  3T1H I;  4R1F A;  4FW6 A;  1KIJ A;  2BR2 A;  4B3S E;  1Z0W A;  3U1K A;  1N34 I;  5FLX Q;  4UT4 A;  2AE8 A;  5K36 C;  2BA0 G;  1U2R A;  4PRX A;  4B3T I;  4LF7 E;  1HR0 E;  2C37 A;  2WP8 A;  2C39 A;  4K0K E;  1NHJ A;  4USM A;  3M6A A;  1N0U A;  3V2U C;  2CVE A;  2NN6 C;  5FLX C;  2R3V A;  1FJG E;  2UUC I;  4X64 E;  5IWA E;  2R42 A;  1I94 I;  1ZXM A;  4MYU A;  3QT7 A;  4JI3 E;  1FI4 A;  5LMN I;  3HUL A;  2UUB E;  2HKE A;  3PS3 A;  3M7N G;  1HNZ I;  4BA1 B;  1H74 A;  1H7U A;  3LNU A;  2ZIT A;  3OTO E;  2PNM A;  2VF3 A;  1Y5Y A;  5EL9 A;  4LF5 I;  4X66 E;  2O3Z A;  1XMO I;  2F4V I;  1OYP A;  2GQ0 A;  4GKK I;  2UXC E;  4X65 I;  5LMU I;  2PNL A;  3J81 Q;  4DXL A;  4DUZ E;  4ZVI A;  2CZ9 A;  1J5E I;  4DPY A;  3L7Z B;  1B62 A;  2IER A;  3T1Y E;  4MYT A;  4IFD E;  4HY1 A;  4LCG A;  1USU A;  4OZE A;  4DV5 E;  1PIE A;  4FW4 A;  4HAC B;  3J81 C;  4DV7 I;  4NXM E;  4DR1 E;  4NBQ A;  2GS8 A;  4OO1 C;  5C0X C;  3K17 A;  3JAM C;  4B3R I;  5BR8 E;  3K1J A;  2HKJ A;  3GME A;  1HNX I;  4DPX A;  1KKH A;  3B82 A;  5JEA F;  2PO2 B;  1XNQ E;  4FW3 A;  2PO1 A;  2VQE I;  4DV2 E;  1Z5C A;  5IT9 C;  4AM3 A;  4AID A;  1IBM I;  2DEJ A;  3QT5 A;  1HK7 A;  3D4J A;  1IBL E;  4FWD A;  5K36 E;  2UXB E;  2E1R A;  2PNZ A;  4YY3 I;  3ZZU A;  4LF4 E;  1N0V C;  4X62 E;  2C38 B;  2UXD E;  4NXN E;  2PO1 B;  4DU8 A;  4AQY E;  4LF9 E;  2NN6 E;  3LTO A;  2JEB A;  1Y6Z A;  4LOM A;  4DV4 I;  4WUB A;  2BA1 D;  1RHY A;  1Y4S A;  4JI2 E;  3U1Y A;  1XXE A;  4IZJ A;  1A6F A;  3B78 A;  3GLL A;  4FWH A;  3PYD A;  1ZXN A;  3QT6 A;  4AQY I;  2OI2 A;  4LFB I;  2IES A;  4UTG A;  1XNR E;  2BV3 A;  4HXZ A;  1Z0G A;  4JI6 I;  4JI8 E;  4Z7Y A;  4M1K A;  2UUA E;  4JI1 E;  4IZK B;  4QNK A;  4OX9 E;  5GMD A;  4GKJ E;  3GCM A;  4IFD A;  4LFC E;  4KHP E;  2V8P A;  4PRV A;  1NHH A;  4FW7 A;  4DR5 I;  4P52 A;  2VQF E;  1FNM A;  2HFU A;  4FN5 A;  3P3C A;  1XHK A;  3T1H E;  4DR3 I;  1D6T A;  4DV1 I;  2BR2 B;  5K36 F;  1ZM4 A;  4JV5 I;  4LF7 I;  2Z5B A;  4LF8 I;  5K36 A;  4K0K I;  5JEA E;  4OO1 E;  1N32 I;  5C0X E;  1MX0 A;  1N34 E;  2V2Z A;  1QZR A;  4OKG A;  3PRY A;  2JE6 A;  3J80 Q;  2NN6 F;  2ZM6 I;  4B3T E;  2CGE A;  2C37 B;  1RRE A;  2C39 B;  2WP8 B;  2IOP A;  2NN6 A;  4JI3 I;  1OYR A;  5DRR A;  4P7A A;  2UUB I;  5GME A;  4DR4 I;  4JI5 E;  4DV6 I;  2UUC E;  3J80 C;  2Z5E A;  3ZKD A;  4B3M I;  1I94 E;  5ELW A;  1Y4U A;  5LMN E;  1N33 I;  4GQU A;  1K47 A;  4JI4 I;  3Q1Q A;  3WU3 A;  1R6M A;  2HHH E;  2JEA A;  1YH8 A;  1RR9 A;  4LFA I;  4JI0 I;  1HNZ E;  4HYM A;  5JEA D;  1E3H A;  5L3J A;  4DR7 I;  3CDJ A;  1Z0B A;  1Z0V A;  3F0N A;  2Q2E B;  1UDN A;  1WUU A;  1Z5A A;  5DNL A;  4MU4 A;  3QT8 A;  3Q6M A;  5DRP A;  2J65 A;  1XMO E;  2F4V E;  4GKK E;  4X65 E;  1Y60 A;  1P42 A;  1HNW I;  4DR6 I;  1R6L A;  4IZJ D;  4NXM I;  4OO1 F;  1KTV A;  2WNR A;  4WUD A;  3ZM7 A;  5C0X F;  5A2Q Q;  2A2C A;  2O1U A;  1H7S A;  5JEA A;  1NHI A;  4OO1 A;  3ZZ0 A;  5C0X A;  4DR2 I;  4JI7 I;  4N3O A;  3CWV A;  4DUY I;  4LF6 I;  4DV7 E;  3ZKB A;  2BM0 A;  2UU9 I;  2X7I A;  3WU4 A;  4B3R E;  3P76 A;  4JYA I;  4BA2 A;  1HNX E;  2V2Q A;  5LL6 R;  5A2Q C;  4IFD D;  3Q6N A;  2Z5C A;  4USK A;  3CDI A;  2VQE E;  3PS2 A;  1ZM2 A;  2BM1 A;  4JG4 A;  2UXD I;  2O1V A;  1IBK I;  4XTJ A;  1IBM E;  3HKM A;  4KQV A;  3B4T A;  3B8H A; 
#chains in the Genus database with same CATH homology
 4MDT A;  4FW3 A;  4FW7 A;  3U1Y A;  1XXE A;  2GO3 A;  4J3D A;  3PS3 A;  5DRO A;  5DRR A;  2GO4 A;  2IES A;  1YHC A;  3UHM A;  2IER A;  3P3C A;  3PS1 A;  4U3B A;  4IS9 A;  3P76 A;  4LCG A;  3NZK A;  4OZE A;  5DRP A;  2J65 A;  2VES A;  4LCH A;  3P3G A;  4MQY A;  4LCF A;  4FW4 A;  5DRQ A;  3P3E A;  1P42 A;  4FW6 A;  3PS2 A;  4ISA A;  1YH8 A;  2O3Z A;  4U3D A;  4FW5 A;  4OKG A;  2JT2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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