2IESA

Crystal structure of aquifex aeolicus lpxc complexed with pyrophosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
267
structure length
267
Chain Sequence
GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of Uridine 5-Diphosphate in the Basic Patch of the Zinc Metalloenzyme Deacetylase LpxC and Implications for Substrate Binding
pubmed doi rcsb
molecule tags Hydrolase
source organism Aquifex aeolicus
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 85
structure length 267
sequence length 267
chains with identical sequence B
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2iesA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2iesA02
2GO4A 5DROA 3NZKA 5DRQA 3PS1A 1XXEA 1YHCA 5DRPA 3UHMA 4U3BA 4FW4A 4FW7A 4MDTA 5DRRA 4FW6A 4ISAA 3U1YA 4U3DA 4J3DA 4FW5A 2J65A 1YH8A 3P3CA 2O3ZA 1P42A 2JT2A 2VESA 4MQYA 2IESA 2GO3A 3P76A 4OKGA 3PS2A 4LCHA 4FW3A 4LCFA 3PS3A 4OZEA 3P3EA 4IS9A 2IERA 4LCGA 3P3GA
chains in the Genus database with same CATH superfamily
2A2CA 3LTOA 3QT6A 1ZM4A 5JEAC 4JI2E 4NXME 2OI2A 2BA0D 4J3DA 1RREA 2ZBKB 2J65A 4DV5I 2CVEA 2UUCI 4DR7I 2CGEA 3PYEA 3B82A 4X64I 2JE6B 3V2UC 4DV2E 4OO1D 2J7KA 2UXBE 5IT9C 1A6FA 3WU3A 3U1YA 1XNQI 4DR6E 4DV4E 5IWAE 2UXCI 1N34E 1YHCA 2EFGA 5DRPA 1PVGA 1OJ4A 3J7AG 1ZM2A 2V2ZA 4HYMA 5FLXC 4Z7CA 1YH8A 4JI5E 2VESA 2JE6A 1N33E 2F1DA 5EKWA 4ED4A 4B3SE 5GMEA 1DARA 1HNWE 4DR2I 4GQUA 2V2QA 3T1YI 5K36E 1HR0E 2NN6C 3M7NG 2A2DA 3ZZTA 1Y4SA 3OTOI 4IFDF 5C0XC 4XTJA 2ZM6E 4DR1E 1N32E 1VI7A 3K1JA 4N3OA 5FLXQ 4PRXA 1USVA 2Z5EA 4JI7I 4LFAE 3ZM7A 1XMQE 4OO1C 4URLA 5A2QQ 2HKJA 2IESA 2PNLA 2O1UA 1UDOA 1RHYA 4OZEA 4LF7I 4JV5I 1D6TA 3ZZUA 1IBLI 3ZKDA 3KRNA 2F4VI 3WU5A 4P52A 4R1FA 4DV1I 4X62I 1HNZI 1R6LA 2PNZB 3T1HI 1PIEA 1XNRI 2UU9E 4FWDA 3J81Q 4WUBA 3P3CA 3LNUA 4DV7E 4JI2I 5JEAD 3PYDA 4NXMI 3ZKBA 4B3ME 2VQEE 3QT5A 3JAMQ 4RPFA 1XMOE 2IOQA 4GKJE 3L7ZB 3J80Q 2PO1B 2BA0G 3HJCA 1Z5CA 4DV2I 2UXBI 3UHMA 4U3BA 2UUAE 4DR6I 4DV4I 5IWAI 2CZ9A 2O1WA 3B4TA 1N34I 3H1CA 4QNKA 4DPYA 4LFBE 5K36B 2BV3A 2VF3A 3P3EA 4JI5I 3L7ZA 4OO1F 2DEIA 5LMNE 4MU3A 1N33I 1Z0WA 2PO1A 5BR8E 4B3SI 1HNWI 3CDJA 1Z0TA 3Q1QA 4PRVA 4LF8E 4LF9E 1HR0I 3PS1A 4MU1A 2NPFA 4FN5A 1MU5A 2NN6D 4DPWA 4UT4A 3LPSA 2VQFE 1U2RA 4MYUA 1ZXNA 1H74A 2ZM6I 5FWKA 5C0XD 1N36E 4BA2B 4DR1I 4JI1E 4AIMA 2E5LE 5K36A 4YY3I 1N32I 1H72C 1VISA 4LPFA 1FWKA 5LMUE 3J7AM 3ZZ0A 4LFAI 1XMQI 2C39B 2PO2B 2AE8A 2V34A 1QZRA 1FKAE 2GO4A 3QT7A 1WUUA 4LF6E 2HFSA 4LF4E 4DU8A 4IZKB 2HFUA 4ZVIA 3M85G 5DRRA 2DEJA 4DXLA 4FW6A 4BA2A 4DPTA 5L3JA 2BA1D 4GKKE 1J5EI 3PYFA 2V2VA 2UU9I 1S16A 2X7IA 3DD6A 5A2QC 1ZXMA 2C39A 2PO2A 4JYAE 4DR3E 4UTGA 4DV7I 4DUZI 4IFDB 3U1KA 4KHPE 4B3MI 1B63A 3P3GA 2V8PA 4OX9E 1K47A 2VQEI 4MU4A 4IZKA 4DV6E 1XMOI 4GKJI 4IZJB 4YY3E 3M6AA 4DUYE 1MG7A 1IBME 3J81C 1FWLA 1HK7A 5JEAF 1KIJA 4B3RE 2UUAI 1Z0CA 3PS2A 1H7SA 4USKA 4IS9A 4IFDA 2HKEA 1USUA 2O1VA 3HULA 4LFBI 1FNMA 3JAMC 3NZKA 4AM3A 4K0KE 3J80C 4X65E 2XEXA 4IZJA 5LMNI 2WNRB 5BR8I 1J5EE 1XHKA 4LF8I 1R6MA 4LF9I 2GS8A 1E3PA 5K36C 2JT2A 4WUDA 1I94E 1NZ0A 4NXNI 4FWHA 3H4LA 4DUZE 4WUCA 2VQFI 3GLLA 2Z5CB 1N36I 4AQYI 4JI1I 2E5LI 1Z0VA 1N0UA 4LCGA 5LMUI 4AIDA 4JI0E 3WU4A 2HHHE 1NHHA 2PNZA 4IFDE 2WNRA 1FJGE 3M7ND 2NN6F 4FW7A 2PO0B 2O1TA 3GMEA 4LF6I 4FW5A 5C0XF 4LF4I 5JEAE 4HY1A 1Z5BA 1S4EA 2C38B 3P76A 4OKGA 4OO1B 4FW3A 1H73A 4MYTA 1UDQA 4GKKI 1NHJA 4JI3E 4LF5E 4JYAI 4HACB 2IOPA 2PO0A 4DR3I 4YHHE 4JI6E 4FW9A 4I3HA 1Z59A 4NXNE 4KHPI 4OX9I 1Z0EA 4DR5E 3GONA 4U3DA 3HKMA 5GMDA 4DV6I 4DV0E 1P42A 3K85A 4OO1A 1OYPA 4AQYE 2R3VA 3P06A 2GO3A 4DUYI 1EA6A 1IBMI 2R42A 1Y4UA 4Z7YA 1MX0A 2IERA 4B3RI 1RR9A 2JEAB 4HACA 1BKNA 5DROA 2UUBE 5DRQA 4EMDA 4DR4E 2NN6E 4ISAA 4K0KI 3D4JA 1ELOA 5C0XE 4X65I 1IBKE 1H7UA 2C37B 4DV3E 4FWGA 1Y5YA 4LCFA 1OYRA 2JEBB 2JEAA 1I94I 1KTVA 4LOMA 4OO1E 2E1RA 5K36D 4JI4E 3PRYA 1XXEA 1HNXE 4BA1B 4B3TE 4JI8E 4JI0I 2HHHI 4X66E 5JEAB 2C37A 1FJGI 1OYSA 3V5RA 2UXDE 4JG4A 5DNLA 2JEBA 2BR2B 1Y6ZA 1KVKA 5IT9Q 5ELWA 2BM1A 1Z0GA 2HK2A 1Y60A 4BA1A 4DV5E 2UUCE 4JI3I 4DR7E 4FW4A 1KKHA 2BM0A 2GQ0A 2ZITA 5JEAA 4X64E 4LF5I 4QNJA 5DNXA 4DPUA 4JI6I 4YHHI 2O3ZA 2BR2A 4DU7A 3M85D 4MQYA 4USMA 5LL6R 2WP8B 4DR5I 1XNQE 3GCMA 3PS3A 2UXCE 1EI1A 3K17A 4DV0I 1UDNA 1ZM3A 4LFCI 4IFDD 2NN6B 3F0NA 4PU9A 3B8HA 2Z5BB 5C0XB 1UDSA 1FI4A 3Q6MA 4DR2E 2UUBI 1ZM9A 4IZJD 3T1YE 4DR4I 4P7AA 4M1KA 4HXZA 1Z5AA 2WP8A 2HK3A 4DPXA 2Z5CA 3OTOE 5EL9A 1IBKI 3CDIA 4DV3I 3B78A 2NN6A 1UEKA 1B62A 2X36A 3PYGA 2Z5BA 4JI7E 5C0XA 2BA1G 4MDTA 4JI4I 1E3HA 2AJ4A 3Q6NA 3QT8A 4LF7E 4JV5E 1HNXI 3WU6A 2PNMA 2LJPA 2C38A 4MU0A 1IBLE 1NHIA 4KQVA 4LCHA 4JI8I 4B3TI 1PKPA 4X66I 2F4VE 4DV1E 2Q2EB 4X62E 4LFCE 4IFDC 5K36F 1HNZE 2UXDI 2CG9A 3CWVA 3T1HE 1N0VC 2WW4A 4NBQA 1Z0BA 1XNRE
chains in the Genus database with same CATH topology
2GO4A 5DROA 3NZKA 5DRQA 3PS1A 1XXEA 1YHCA 5DRPA 3UHMA 4U3BA 4FW4A 4FW7A 4MDTA 5DRRA 4FW6A 4ISAA 3U1YA 4U3DA 4J3DA 4FW5A 2J65A 1YH8A 3P3CA 2O3ZA 1P42A 2JT2A 2VESA 4MQYA 2IESA 2GO3A 3P76A 4OKGA 3PS2A 4LCHA 4FW3A 4LCFA 3PS3A 4OZEA 3P3EA 4IS9A 2IERA 4LCGA 3P3GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GO4 A;  5DRO A;  3NZK A;  5DRQ A;  3PS1 A;  1XXE A;  1YHC A;  5DRP A;  3UHM A;  4U3B A;  4FW4 A;  4FW7 A;  4MDT A;  5DRR A;  4FW6 A;  4ISA A;  3U1Y A;  4U3D A;  4J3D A;  4FW5 A;  2J65 A;  1YH8 A;  3P3C A;  2O3Z A;  1P42 A;  2JT2 A;  2VES A;  4MQY A;  2IES A;  2GO3 A;  3P76 A;  4OKG A;  3PS2 A;  4LCH A;  4FW3 A;  4LCF A;  3PS3 A;  4OZE A;  3P3E A;  4IS9 A;  2IER A;  4LCG A;  3P3G A; 
#chains in the Genus database with same CATH topology
 2A2C A;  3LTO A;  3QT6 A;  1ZM4 A;  5JEA C;  4JI2 E;  4NXM E;  2OI2 A;  2BA0 D;  4J3D A;  1RRE A;  2ZBK B;  2J65 A;  4DV5 I;  2CVE A;  2UUC I;  4DR7 I;  2CGE A;  3PYE A;  3B82 A;  4X64 I;  2JE6 B;  3V2U C;  4DV2 E;  4OO1 D;  2J7K A;  2UXB E;  5IT9 C;  1A6F A;  3WU3 A;  3U1Y A;  1XNQ I;  4DR6 E;  4DV4 E;  5IWA E;  2UXC I;  1N34 E;  1YHC A;  2EFG A;  5DRP A;  1PVG A;  1OJ4 A;  3J7A G;  1ZM2 A;  2V2Z A;  4HYM A;  5FLX C;  4Z7C A;  1YH8 A;  4JI5 E;  2VES A;  2JE6 A;  1N33 E;  2F1D A;  5EKW A;  4ED4 A;  4B3S E;  5GME A;  1DAR A;  1HNW E;  4DR2 I;  4GQU A;  2V2Q A;  3T1Y I;  5K36 E;  1HR0 E;  2NN6 C;  3M7N G;  2A2D A;  3ZZT A;  1Y4S A;  3OTO I;  4IFD F;  5C0X C;  4XTJ A;  2ZM6 E;  4DR1 E;  1N32 E;  1VI7 A;  3K1J A;  4N3O A;  5FLX Q;  4PRX A;  1USV A;  2Z5E A;  4JI7 I;  4LFA E;  3ZM7 A;  1XMQ E;  4OO1 C;  4URL A;  5A2Q Q;  2HKJ A;  2IES A;  2PNL A;  2O1U A;  1UDO A;  1RHY A;  4OZE A;  4LF7 I;  4JV5 I;  1D6T A;  3ZZU A;  1IBL I;  3ZKD A;  3KRN A;  2F4V I;  3WU5 A;  4P52 A;  4R1F A;  4DV1 I;  4X62 I;  1HNZ I;  1R6L A;  2PNZ B;  3T1H I;  1PIE A;  1XNR I;  2UU9 E;  4FWD A;  3J81 Q;  4WUB A;  3P3C A;  3LNU A;  4DV7 E;  4JI2 I;  5JEA D;  3PYD A;  4NXM I;  3ZKB A;  4B3M E;  2VQE E;  3QT5 A;  3JAM Q;  4RPF A;  1XMO E;  2IOQ A;  4GKJ E;  3L7Z B;  3J80 Q;  2PO1 B;  2BA0 G;  3HJC A;  1Z5C A;  4DV2 I;  2UXB I;  3UHM A;  4U3B A;  2UUA E;  4DR6 I;  4DV4 I;  5IWA I;  2CZ9 A;  2O1W A;  3B4T A;  1N34 I;  3H1C A;  4QNK A;  4DPY A;  4LFB E;  5K36 B;  2BV3 A;  2VF3 A;  3P3E A;  4JI5 I;  3L7Z A;  4OO1 F;  2DEI A;  5LMN E;  4MU3 A;  1N33 I;  1Z0W A;  2PO1 A;  5BR8 E;  4B3S I;  1HNW I;  3CDJ A;  1Z0T A;  3Q1Q A;  4PRV A;  4LF8 E;  4LF9 E;  1HR0 I;  3PS1 A;  4MU1 A;  2NPF A;  4FN5 A;  1MU5 A;  2NN6 D;  4DPW A;  4UT4 A;  3LPS A;  2VQF E;  1U2R A;  4MYU A;  1ZXN A;  1H74 A;  2ZM6 I;  5FWK A;  5C0X D;  1N36 E;  4BA2 B;  4DR1 I;  4JI1 E;  4AIM A;  2E5L E;  5K36 A;  4YY3 I;  1N32 I;  1H72 C;  1VIS A;  4LPF A;  1FWK A;  5LMU E;  3J7A M;  3ZZ0 A;  4LFA I;  1XMQ I;  2C39 B;  2PO2 B;  2AE8 A;  2V34 A;  1QZR A;  1FKA E;  2GO4 A;  3QT7 A;  1WUU A;  4LF6 E;  2HFS A;  4LF4 E;  4DU8 A;  4IZK B;  2HFU A;  4ZVI A;  3M85 G;  5DRR A;  2DEJ A;  4DXL A;  4FW6 A;  4BA2 A;  4DPT A;  5L3J A;  2BA1 D;  4GKK E;  1J5E I;  3PYF A;  2V2V A;  2UU9 I;  1S16 A;  2X7I A;  3DD6 A;  5A2Q C;  1ZXM A;  2C39 A;  2PO2 A;  4JYA E;  4DR3 E;  4UTG A;  4DV7 I;  4DUZ I;  4IFD B;  3U1K A;  4KHP E;  4B3M I;  1B63 A;  3P3G A;  2V8P A;  4OX9 E;  1K47 A;  2VQE I;  4MU4 A;  4IZK A;  4DV6 E;  1XMO I;  4GKJ I;  4IZJ B;  4YY3 E;  3M6A A;  4DUY E;  1MG7 A;  1IBM E;  3J81 C;  1FWL A;  1HK7 A;  5JEA F;  1KIJ A;  4B3R E;  2UUA I;  1Z0C A;  3PS2 A;  1H7S A;  4USK A;  4IS9 A;  4IFD A;  2HKE A;  1USU A;  2O1V A;  3HUL A;  4LFB I;  1FNM A;  3JAM C;  3NZK A;  4AM3 A;  4K0K E;  3J80 C;  4X65 E;  2XEX A;  4IZJ A;  5LMN I;  2WNR B;  5BR8 I;  1J5E E;  1XHK A;  4LF8 I;  1R6M A;  4LF9 I;  2GS8 A;  1E3P A;  5K36 C;  2JT2 A;  4WUD A;  1I94 E;  1NZ0 A;  4NXN I;  4FWH A;  3H4L A;  4DUZ E;  4WUC A;  2VQF I;  3GLL A;  2Z5C B;  1N36 I;  4AQY I;  4JI1 I;  2E5L I;  1Z0V A;  1N0U A;  4LCG A;  5LMU I;  4AID A;  4JI0 E;  3WU4 A;  2HHH E;  1NHH A;  2PNZ A;  4IFD E;  2WNR A;  1FJG E;  3M7N D;  2NN6 F;  4FW7 A;  2PO0 B;  2O1T A;  3GME A;  4LF6 I;  4FW5 A;  5C0X F;  4LF4 I;  5JEA E;  4HY1 A;  1Z5B A;  1S4E A;  2C38 B;  3P76 A;  4OKG A;  4OO1 B;  4FW3 A;  1H73 A;  4MYT A;  1UDQ A;  4GKK I;  1NHJ A;  4JI3 E;  4LF5 E;  4JYA I;  4HAC B;  2IOP A;  2PO0 A;  4DR3 I;  4YHH E;  4JI6 E;  4FW9 A;  4I3H A;  1Z59 A;  4NXN E;  4KHP I;  4OX9 I;  1Z0E A;  4DR5 E;  3GON A;  4U3D A;  3HKM A;  5GMD A;  4DV6 I;  4DV0 E;  1P42 A;  3K85 A;  4OO1 A;  1OYP A;  4AQY E;  2R3V A;  3P06 A;  2GO3 A;  4DUY I;  1EA6 A;  1IBM I;  2R42 A;  1Y4U A;  4Z7Y A;  1MX0 A;  2IER A;  4B3R I;  1RR9 A;  2JEA B;  4HAC A;  1BKN A;  5DRO A;  2UUB E;  5DRQ A;  4EMD A;  4DR4 E;  2NN6 E;  4ISA A;  4K0K I;  3D4J A;  1ELO A;  5C0X E;  4X65 I;  1IBK E;  1H7U A;  2C37 B;  4DV3 E;  4FWG A;  1Y5Y A;  4LCF A;  1OYR A;  2JEB B;  2JEA A;  1I94 I;  1KTV A;  4LOM A;  4OO1 E;  2E1R A;  5K36 D;  4JI4 E;  3PRY A;  1XXE A;  1HNX E;  4BA1 B;  4B3T E;  4JI8 E;  4JI0 I;  2HHH I;  4X66 E;  5JEA B;  2C37 A;  1FJG I;  1OYS A;  3V5R A;  2UXD E;  4JG4 A;  5DNL A;  2JEB A;  2BR2 B;  1Y6Z A;  1KVK A;  5IT9 Q;  5ELW A;  2BM1 A;  1Z0G A;  2HK2 A;  1Y60 A;  4BA1 A;  4DV5 E;  2UUC E;  4JI3 I;  4DR7 E;  4FW4 A;  1KKH A;  2BM0 A;  2GQ0 A;  2ZIT A;  5JEA A;  4X64 E;  4LF5 I;  4QNJ A;  5DNX A;  4DPU A;  4JI6 I;  4YHH I;  2O3Z A;  2BR2 A;  4DU7 A;  3M85 D;  4MQY A;  4USM A;  5LL6 R;  2WP8 B;  4DR5 I;  1XNQ E;  3GCM A;  3PS3 A;  2UXC E;  1EI1 A;  3K17 A;  4DV0 I;  1UDN A;  1ZM3 A;  4LFC I;  4IFD D;  2NN6 B;  3F0N A;  4PU9 A;  3B8H A;  2Z5B B;  5C0X B;  1UDS A;  1FI4 A;  3Q6M A;  4DR2 E;  2UUB I;  1ZM9 A;  4IZJ D;  3T1Y E;  4DR4 I;  4P7A A;  4M1K A;  4HXZ A;  1Z5A A;  2WP8 A;  2HK3 A;  4DPX A;  2Z5C A;  3OTO E;  5EL9 A;  1IBK I;  3CDI A;  4DV3 I;  3B78 A;  2NN6 A;  1UEK A;  1B62 A;  2X36 A;  3PYG A;  2Z5B A;  4JI7 E;  5C0X A;  2BA1 G;  4MDT A;  4JI4 I;  1E3H A;  2AJ4 A;  3Q6N A;  3QT8 A;  4LF7 E;  4JV5 E;  1HNX I;  3WU6 A;  2PNM A;  2LJP A;  2C38 A;  4MU0 A;  1IBL E;  1NHI A;  4KQV A;  4LCH A;  4JI8 I;  4B3T I;  1PKP A;  4X66 I;  2F4V E;  4DV1 E;  2Q2E B;  4X62 E;  4LFC E;  4IFD C;  5K36 F;  1HNZ E;  2UXD I;  2CG9 A;  3CWV A;  3T1H E;  1N0V C;  2WW4 A;  4NBQ A;  1Z0B A;  1XNR E; 
#chains in the Genus database with same CATH homology
 2GO4 A;  5DRO A;  3NZK A;  5DRQ A;  3PS1 A;  1XXE A;  1YHC A;  5DRP A;  3UHM A;  4U3B A;  4FW4 A;  4FW7 A;  4MDT A;  5DRR A;  4FW6 A;  4ISA A;  3U1Y A;  4U3D A;  4J3D A;  4FW5 A;  2J65 A;  1YH8 A;  3P3C A;  2O3Z A;  1P42 A;  2JT2 A;  2VES A;  4MQY A;  2IES A;  2GO3 A;  3P76 A;  4OKG A;  3PS2 A;  4LCH A;  4FW3 A;  4LCF A;  3PS3 A;  4OZE A;  3P3E A;  4IS9 A;  2IER A;  4LCG A;  3P3G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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