2VESA

Crystal structure of lpxc from pseudomonas aeruginosa complexed with the potent bb-78485 inhibitor
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
294
structure length
294
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Pseudomonas aeruginosa
publication title Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
pubmed doi rcsb
molecule keywords UDP-3-O-acyl-N-acetylglucosamine deacetylase
total genus 88
structure length 294
sequence length 294
chains with identical sequence B, C
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2007-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 2vesA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 2vesA02
1XXEA 1P42A 2IERA 5DRQA 4FW3A 2JT2A 2J65A 3PS2A 4MQYA 4OKGA 2VESA 4FW4A 4LCFA 3NZKA 4MDTA 1YHCA 4ISAA 5DRPA 2GO3A 2IESA 4FW6A 3U1YA 2GO4A 4FW7A 4LCHA 4IS9A 4U3BA 3UHMA 3P3GA 3P3EA 3PS1A 2O3ZA 3PS3A 4LCGA 1YH8A 3P3CA 3P76A 4OZEA 5DRRA 4U3DA 4J3DA 5DROA 4FW5A
chains in the Genus database with same CATH superfamily
2BR2A 1I94I 2C39B 3KRNA 2OI2A 5C0XE 4X65E 4JI2E 4OO1C 4AQYI 4LCFA 4MYUA 1N33E 4EMDA 1H72C 5K36F 3D4JA 4DR3E 1FNMA 2LJPA 2BV3A 4DPTA 1FJGI 4OO1B 4KQVA 4DV1E 4DV3E 4DR7I 2PO2B 2CGEA 2BA1D 4JI7I 1A6FA 1MX0A 2NN6A 4PRVA 1UDSA 5JEAD 2IERA 2A2CA 3M85G 1ZM3A 5ELWA 4YY3E 4JI3E 1Y4UA 1KKHA 4B3SE 2PO1A 4IFDC 1RREA 2JE6A 2WNRA 4OX9E 3JAMC 1N0UA 2BA0G 4JG4A 1H7SA 5DRRA 4IFDB 1ZXMA 1HNXI 4NXNI 4DPWA 4I3HA 2BA0D 4DV2I 4X62E 1HR0E 4LF7I 3L7ZB 2JEBA 1HNZI 4DU7A 3OTOI 4JI1I 1NHHA 4MDTA 4X64E 4X66I 3ZZTA 2IESA 3U1YA 2VQFI 1IBKI 2C38B 2GO4A 4M1KA 5BR8I 1XMOE 4UT4A 4HACB 4GKKE 5JEAF 3M7ND 4DR5E 2UXDI 4FW5A 4LF5E 2C37B 2Q2EB 3WU5A 2PO2A 1U2RA 2HFUA 2R42A 2J65A 4DV6E 3PRYA 2IOPA 5JEAE 4ED4A 4X65I 2UUAE 4JI2I 2GO3A 1N33I 2O1UA 1NZ0A 4DR3I 2O1TA 2PNMA 5K36D 2PNZA 4LPFA 1ELOA 4USMA 5C0XC 4LF6E 3P76A 4LOMA 4DV1I 4DV3I 4MU0A 4MU4A 5C0XB 3T1YE 4IZJA 1P42A 2UU9E 4YY3I 4JI3I 2PO0B 2WP8B 2EFGA 3HULA 4B3SI 1IBLE 4LF8E 1Y5YA 2XEXA 1HNWE 4AIDA 3P3GA 1S4EA 2Z5BB 4FWGA 5K36B 1WUUA 3PS3A 3PYGA 4JI6E 2X7IA 3CWVA 3M6AA 2BM0A 1B62A 3HKMA 2E5LE 2F1DA 4WUDA 4X62I 1HR0I 4HYMA 3PYEA 4OKGA 2C37A 4UTGA 4X64I 2NN6F 3QT6A 4MU1A 1KIJA 3QT5A 4IS9A 4LCHA 1B63A 5IT9Q 4NBQA 4HXZA 4DV5E 1XMOI 2AE8A 3K1JA 1OYPA 1FWKA 1OYRA 4BA2A 4GKKI 5K36E 4DR5I 1XHKA 2V2VA 4LF5I 1XXEA 5DRQA 4JI8E 5DNXA 4P52A 4DV6I 3Q6MA 1VI7A 2UUAI 2JEAA 2HKJA 3WU4A 4DV4E 4LF9E 4FWHA 4MYTA 1Z0GA 1EA6A 4QNKA 4U3BA 4DR1E 4B3ME 1H74A 3P3EA 4IZKB 3PS1A 4IZJD 4KHPE 3M85D 4LF6I 3Q1QA 1RR9A 1J5EE 5JEAC 5A2QQ 4DPXA 4Z7CA 1N32E 4BA1B 1Z0VA 3LTOA 1XMQE 4WUCA 5JEAB 5FLXQ 3T1YI 2V34A 3J7AG 2HK2A 1USVA 2UU9I 2O1VA 5IT9C 2O1WA 3J81Q 1D6TA 2V2QA 1Z0TA 3K17A 3B78A 4OO1F 1UDNA 3WU3A 2C39A 1IBLI 4LF8I 4YHHE 3F0NA 3T1HE 1HNWI 2ZM6E 2CZ9A 1FWLA 4JI6I 1N34E 1Z0BA 1E3PA 4ZVIA 4B3TE 4URLA 4K0KE 3H4LA 1I94E 1Z5BA 4MU3A 1Z5AA 1BKNA 4OO1A 1IBME 3J7AM 2V2ZA 4GKJE 1OJ4A 2BM1A 3NZKA 4DUZE 5LMUE 3ZKBA 2NN6D 4B3RE 1ZXNA 2BR2B 4DXLA 4WUBA 4DV5I 4FWDA 2VF3A 4U3DA 2F4VE 1R6LA 2R3VA 3LPSA 3J81C 3GMEA 1EI1A 4BA1A 3PS2A 4IFDA 4DR6E 4JI8I 2IOQA 4JI5E 1H73A 4N3OA 5K36C 3HJCA 4AIMA 1XNQE 4DV4I 4LF9I 3B82A 4DR1I 4B3MI 2NN6B 3L7ZA 3U1KA 5L3JA 4OX9I 2CG9A 3ZM7A 4KHPI 1H7UA 1J5EI 1E3HA 4FN5A 1OYSA 2C38A 4QNJA 1Y60A 2VQEE 1N32I 1K47A 3DD6A 1XMQI 4JV5E 2PO1B 2Z5CB 2E1RA 3WU6A 2JE6B 4HACA 2WNRB 1Z59A 4DU8A 4NXME 4X66E 4LFAE 1FKAE 5DRPA 2X36A 1DARA 2HHHE 4FW7A 4YHHI 3T1HI 3J80Q 2ZM6I 4OO1D 3B8HA 4DV0E 1Z0WA 2ZITA 1N34I 4OZEA 1FI4A 5GMDA 2NN6E 2JEBB 4JYAE 4P7AA 4B3TI 5DROA 4K0KI 1PVGA 2PNLA 1IBMI 4LFBE 3B4TA 3QT7A 4GKJI 2BA1G 4FW4A 2Z5EA 5C0XA 2J7KA 4DR2E 5FWKA 4DUZI 5LMUI 3UHMA 2GS8A 2WW4A 4B3RI 1YH8A 3P3CA 2PO0A 4DR4E 2WP8A 4IFDD 1N36E 3GONA 2F4VI 2Z5BA 4DV7E 5K36A 1MG7A 4LF4E 1Z0EA 2UXBE 4USKA 4XTJA 5DNLA 3ZZ0A 2AJ4A 3CDJA 4MQYA 5LL6R 2PNZB 4DR6I 4LFCE 2Z5CA 2VESA 1UEKA 4JI5I 3J80C 4R1FA 4JI0E 1XNQI 4GQUA 2UUCE 1UDOA 1R6MA 3GCMA 5IWAE 4DUYE 2UUBE 1PKPA 2O3ZA 1Z0CA 4IZJB 5LMNE 2UXCE 4JI4E 4RPFA 1XNRE 2HK3A 4OO1E 3K85A 1KVKA 2VQEI 2A2DA 5EKWA 4JV5I 1NHJA 4HY1A 3GLLA 2E5LI 1UDQA 4NXMI 4AQYE 3ZKDA 4LFAI 1QZRA 3M7NG 1USUA 2HKEA 1ZM9A 2HHHI 3ZZUA 4FW9A 4DPYA 1FJGE 1Z5CA 5A2QC 4DV0I 4IFDF 4DR7E 5GMEA 2ZBKB 4JI7E 4J3DA 1HK7A 5FLXC 1Y6ZA 5C0XD 4IZKA 2HFSA 4JYAI 1S16A 4IFDE 3PYFA 2GQ0A 4FW3A 2JT2A 4LFBI 5EL9A 2NN6C 3PYDA 4ISAA 1Y4SA 2DEJA 4Z7YA 5JEAA 4DR2I 2V8PA 4PRXA 3V5RA 4BA2B 1N0VC 4DPUA 1NHIA 4DR4I 3QT8A 4AM3A 1N36I 4PU9A 1MU5A 1HNXE 2DEIA 4NXNE 4DV7I 4LF4I 2JEAB 2UXBI 2CVEA 4DV2E 4LF7E 1PIEA 1VISA 1HNZE 3OTOE 4JI1E 4LFCI 1YHCA 3V2UC 2VQFE 1IBKE 4FW6A 1KTVA 2NPFA 4JI0I 3LNUA 5BR8E 3H1CA 2UUCI 4LCGA 5IWAI 4DUYI 2UUBI 3CDIA 3Q6NA 3JAMQ 5LMNI 2UXCI 4JI4I 1RHYA 5C0XF 1ZM2A 1XNRI 3P06A 2UXDE 1ZM4A
chains in the Genus database with same CATH topology
1XXEA 1P42A 2IERA 5DRQA 4FW3A 2JT2A 2J65A 3PS2A 4MQYA 4OKGA 2VESA 4FW4A 4LCFA 3NZKA 4MDTA 1YHCA 4ISAA 5DRPA 2GO3A 2IESA 4FW6A 3U1YA 2GO4A 4FW7A 4LCHA 4IS9A 4U3BA 3UHMA 3P3GA 3P3EA 3PS1A 2O3ZA 3PS3A 4LCGA 1YH8A 3P3CA 3P76A 4OZEA 5DRRA 4U3DA 4J3DA 5DROA 4FW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XXE A;  1P42 A;  2IER A;  5DRQ A;  4FW3 A;  2JT2 A;  2J65 A;  3PS2 A;  4MQY A;  4OKG A;  2VES A;  4FW4 A;  4LCF A;  3NZK A;  4MDT A;  1YHC A;  4ISA A;  5DRP A;  2GO3 A;  2IES A;  4FW6 A;  3U1Y A;  2GO4 A;  4FW7 A;  4LCH A;  4IS9 A;  4U3B A;  3UHM A;  3P3G A;  3P3E A;  3PS1 A;  2O3Z A;  3PS3 A;  4LCG A;  1YH8 A;  3P3C A;  3P76 A;  4OZE A;  5DRR A;  4U3D A;  4J3D A;  5DRO A;  4FW5 A; 
#chains in the Genus database with same CATH topology
 2BR2 A;  1I94 I;  2C39 B;  3KRN A;  2OI2 A;  5C0X E;  4X65 E;  4JI2 E;  4OO1 C;  4AQY I;  4LCF A;  4MYU A;  1N33 E;  4EMD A;  1H72 C;  5K36 F;  3D4J A;  4DR3 E;  1FNM A;  2LJP A;  2BV3 A;  4DPT A;  1FJG I;  4OO1 B;  4KQV A;  4DV1 E;  4DV3 E;  4DR7 I;  2PO2 B;  2CGE A;  2BA1 D;  4JI7 I;  1A6F A;  1MX0 A;  2NN6 A;  4PRV A;  1UDS A;  5JEA D;  2IER A;  2A2C A;  3M85 G;  1ZM3 A;  5ELW A;  4YY3 E;  4JI3 E;  1Y4U A;  1KKH A;  4B3S E;  2PO1 A;  4IFD C;  1RRE A;  2JE6 A;  2WNR A;  4OX9 E;  3JAM C;  1N0U A;  2BA0 G;  4JG4 A;  1H7S A;  5DRR A;  4IFD B;  1ZXM A;  1HNX I;  4NXN I;  4DPW A;  4I3H A;  2BA0 D;  4DV2 I;  4X62 E;  1HR0 E;  4LF7 I;  3L7Z B;  2JEB A;  1HNZ I;  4DU7 A;  3OTO I;  4JI1 I;  1NHH A;  4MDT A;  4X64 E;  4X66 I;  3ZZT A;  2IES A;  3U1Y A;  2VQF I;  1IBK I;  2C38 B;  2GO4 A;  4M1K A;  5BR8 I;  1XMO E;  4UT4 A;  4HAC B;  4GKK E;  5JEA F;  3M7N D;  4DR5 E;  2UXD I;  4FW5 A;  4LF5 E;  2C37 B;  2Q2E B;  3WU5 A;  2PO2 A;  1U2R A;  2HFU A;  2R42 A;  2J65 A;  4DV6 E;  3PRY A;  2IOP A;  5JEA E;  4ED4 A;  4X65 I;  2UUA E;  4JI2 I;  2GO3 A;  1N33 I;  2O1U A;  1NZ0 A;  4DR3 I;  2O1T A;  2PNM A;  5K36 D;  2PNZ A;  4LPF A;  1ELO A;  4USM A;  5C0X C;  4LF6 E;  3P76 A;  4LOM A;  4DV1 I;  4DV3 I;  4MU0 A;  4MU4 A;  5C0X B;  3T1Y E;  4IZJ A;  1P42 A;  2UU9 E;  4YY3 I;  4JI3 I;  2PO0 B;  2WP8 B;  2EFG A;  3HUL A;  4B3S I;  1IBL E;  4LF8 E;  1Y5Y A;  2XEX A;  1HNW E;  4AID A;  3P3G A;  1S4E A;  2Z5B B;  4FWG A;  5K36 B;  1WUU A;  3PS3 A;  3PYG A;  4JI6 E;  2X7I A;  3CWV A;  3M6A A;  2BM0 A;  1B62 A;  3HKM A;  2E5L E;  2F1D A;  4WUD A;  4X62 I;  1HR0 I;  4HYM A;  3PYE A;  4OKG A;  2C37 A;  4UTG A;  4X64 I;  2NN6 F;  3QT6 A;  4MU1 A;  1KIJ A;  3QT5 A;  4IS9 A;  4LCH A;  1B63 A;  5IT9 Q;  4NBQ A;  4HXZ A;  4DV5 E;  1XMO I;  2AE8 A;  3K1J A;  1OYP A;  1FWK A;  1OYR A;  4BA2 A;  4GKK I;  5K36 E;  4DR5 I;  1XHK A;  2V2V A;  4LF5 I;  1XXE A;  5DRQ A;  4JI8 E;  5DNX A;  4P52 A;  4DV6 I;  3Q6M A;  1VI7 A;  2UUA I;  2JEA A;  2HKJ A;  3WU4 A;  4DV4 E;  4LF9 E;  4FWH A;  4MYT A;  1Z0G A;  1EA6 A;  4QNK A;  4U3B A;  4DR1 E;  4B3M E;  1H74 A;  3P3E A;  4IZK B;  3PS1 A;  4IZJ D;  4KHP E;  3M85 D;  4LF6 I;  3Q1Q A;  1RR9 A;  1J5E E;  5JEA C;  5A2Q Q;  4DPX A;  4Z7C A;  1N32 E;  4BA1 B;  1Z0V A;  3LTO A;  1XMQ E;  4WUC A;  5JEA B;  5FLX Q;  3T1Y I;  2V34 A;  3J7A G;  2HK2 A;  1USV A;  2UU9 I;  2O1V A;  5IT9 C;  2O1W A;  3J81 Q;  1D6T A;  2V2Q A;  1Z0T A;  3K17 A;  3B78 A;  4OO1 F;  1UDN A;  3WU3 A;  2C39 A;  1IBL I;  4LF8 I;  4YHH E;  3F0N A;  3T1H E;  1HNW I;  2ZM6 E;  2CZ9 A;  1FWL A;  4JI6 I;  1N34 E;  1Z0B A;  1E3P A;  4ZVI A;  4B3T E;  4URL A;  4K0K E;  3H4L A;  1I94 E;  1Z5B A;  4MU3 A;  1Z5A A;  1BKN A;  4OO1 A;  1IBM E;  3J7A M;  2V2Z A;  4GKJ E;  1OJ4 A;  2BM1 A;  3NZK A;  4DUZ E;  5LMU E;  3ZKB A;  2NN6 D;  4B3R E;  1ZXN A;  2BR2 B;  4DXL A;  4WUB A;  4DV5 I;  4FWD A;  2VF3 A;  4U3D A;  2F4V E;  1R6L A;  2R3V A;  3LPS A;  3J81 C;  3GME A;  1EI1 A;  4BA1 A;  3PS2 A;  4IFD A;  4DR6 E;  4JI8 I;  2IOQ A;  4JI5 E;  1H73 A;  4N3O A;  5K36 C;  3HJC A;  4AIM A;  1XNQ E;  4DV4 I;  4LF9 I;  3B82 A;  4DR1 I;  4B3M I;  2NN6 B;  3L7Z A;  3U1K A;  5L3J A;  4OX9 I;  2CG9 A;  3ZM7 A;  4KHP I;  1H7U A;  1J5E I;  1E3H A;  4FN5 A;  1OYS A;  2C38 A;  4QNJ A;  1Y60 A;  2VQE E;  1N32 I;  1K47 A;  3DD6 A;  1XMQ I;  4JV5 E;  2PO1 B;  2Z5C B;  2E1R A;  3WU6 A;  2JE6 B;  4HAC A;  2WNR B;  1Z59 A;  4DU8 A;  4NXM E;  4X66 E;  4LFA E;  1FKA E;  5DRP A;  2X36 A;  1DAR A;  2HHH E;  4FW7 A;  4YHH I;  3T1H I;  3J80 Q;  2ZM6 I;  4OO1 D;  3B8H A;  4DV0 E;  1Z0W A;  2ZIT A;  1N34 I;  4OZE A;  1FI4 A;  5GMD A;  2NN6 E;  2JEB B;  4JYA E;  4P7A A;  4B3T I;  5DRO A;  4K0K I;  1PVG A;  2PNL A;  1IBM I;  4LFB E;  3B4T A;  3QT7 A;  4GKJ I;  2BA1 G;  4FW4 A;  2Z5E A;  5C0X A;  2J7K A;  4DR2 E;  5FWK A;  4DUZ I;  5LMU I;  3UHM A;  2GS8 A;  2WW4 A;  4B3R I;  1YH8 A;  3P3C A;  2PO0 A;  4DR4 E;  2WP8 A;  4IFD D;  1N36 E;  3GON A;  2F4V I;  2Z5B A;  4DV7 E;  5K36 A;  1MG7 A;  4LF4 E;  1Z0E A;  2UXB E;  4USK A;  4XTJ A;  5DNL A;  3ZZ0 A;  2AJ4 A;  3CDJ A;  4MQY A;  5LL6 R;  2PNZ B;  4DR6 I;  4LFC E;  2Z5C A;  2VES A;  1UEK A;  4JI5 I;  3J80 C;  4R1F A;  4JI0 E;  1XNQ I;  4GQU A;  2UUC E;  1UDO A;  1R6M A;  3GCM A;  5IWA E;  4DUY E;  2UUB E;  1PKP A;  2O3Z A;  1Z0C A;  4IZJ B;  5LMN E;  2UXC E;  4JI4 E;  4RPF A;  1XNR E;  2HK3 A;  4OO1 E;  3K85 A;  1KVK A;  2VQE I;  2A2D A;  5EKW A;  4JV5 I;  1NHJ A;  4HY1 A;  3GLL A;  2E5L I;  1UDQ A;  4NXM I;  4AQY E;  3ZKD A;  4LFA I;  1QZR A;  3M7N G;  1USU A;  2HKE A;  1ZM9 A;  2HHH I;  3ZZU A;  4FW9 A;  4DPY A;  1FJG E;  1Z5C A;  5A2Q C;  4DV0 I;  4IFD F;  4DR7 E;  5GME A;  2ZBK B;  4JI7 E;  4J3D A;  1HK7 A;  5FLX C;  1Y6Z A;  5C0X D;  4IZK A;  2HFS A;  4JYA I;  1S16 A;  4IFD E;  3PYF A;  2GQ0 A;  4FW3 A;  2JT2 A;  4LFB I;  5EL9 A;  2NN6 C;  3PYD A;  4ISA A;  1Y4S A;  2DEJ A;  4Z7Y A;  5JEA A;  4DR2 I;  2V8P A;  4PRX A;  3V5R A;  4BA2 B;  1N0V C;  4DPU A;  1NHI A;  4DR4 I;  3QT8 A;  4AM3 A;  1N36 I;  4PU9 A;  1MU5 A;  1HNX E;  2DEI A;  4NXN E;  4DV7 I;  4LF4 I;  2JEA B;  2UXB I;  2CVE A;  4DV2 E;  4LF7 E;  1PIE A;  1VIS A;  1HNZ E;  3OTO E;  4JI1 E;  4LFC I;  1YHC A;  3V2U C;  2VQF E;  1IBK E;  4FW6 A;  1KTV A;  2NPF A;  4JI0 I;  3LNU A;  5BR8 E;  3H1C A;  2UUC I;  4LCG A;  5IWA I;  4DUY I;  2UUB I;  3CDI A;  3Q6N A;  3JAM Q;  5LMN I;  2UXC I;  4JI4 I;  1RHY A;  5C0X F;  1ZM2 A;  1XNR I;  3P06 A;  2UXD E;  1ZM4 A; 
#chains in the Genus database with same CATH homology
 1XXE A;  1P42 A;  2IER A;  5DRQ A;  4FW3 A;  2JT2 A;  2J65 A;  3PS2 A;  4MQY A;  4OKG A;  2VES A;  4FW4 A;  4LCF A;  3NZK A;  4MDT A;  1YHC A;  4ISA A;  5DRP A;  2GO3 A;  2IES A;  4FW6 A;  3U1Y A;  2GO4 A;  4FW7 A;  4LCH A;  4IS9 A;  4U3B A;  3UHM A;  3P3G A;  3P3E A;  3PS1 A;  2O3Z A;  3PS3 A;  4LCG A;  1YH8 A;  3P3C A;  3P76 A;  4OZE A;  5DRR A;  4U3D A;  4J3D A;  5DRO A;  4FW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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