4FW4A

Crystal structure of the lpxc in complex with n-[(1s,2r)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide inhibitor
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
300
structure length
300
Chain Sequence
AMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the LpxC
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Pseudomonas aeruginosa
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 89
structure length 300
sequence length 300
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw4A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw4A02
2J65A 5DRRA 4LCHA 5DRQA 2IESA 3PS2A 4MQYA 4U3DA 3P3CA 3NZKA 2GO3A 4FW3A 5DROA 2O3ZA 3U1YA 4MDTA 4LCGA 4FW6A 3UHMA 1XXEA 1YH8A 1P42A 2JT2A 2VESA 3P3EA 3PS3A 3PS1A 5DRPA 4LCFA 2IERA 4FW4A 4IS9A 4ISAA 1YHCA 3P3GA 3P76A 4FW7A 4OKGA 4OZEA 4FW5A 4J3DA 4U3BA 2GO4A
chains in the Genus database with same CATH superfamily
3JAMC 1H72C 2PNMA 4DR5I 2PO1A 4LFCI 4MQYA 4U3DA 4YHHI 2R3VA 4NXNI 2V2ZA 4X66I 5LMUE 1KKHA 3T1YE 4GKJE 3UHMA 4DV7E 2BA1G 3PYGA 3M6AA 3GMEA 2JE6B 4Z7YA 5EL9A 5ELWA 2PO0B 4NBQA 4AIMA 4LF4E 4FW3A 2O1UA 5K36C 2IOPA 4MU0A 1QZRA 5C0XC 4OO1B 1XXEA 1NZ0A 1H7UA 2PNZB 4X65E 4WUCA 2O1WA 2Z5BB 3QT7A 4DPUA 4R1FA 4BA2A 2Q2EB 4X65I 4I3HA 2PO1B 1MG7A 4AQYE 1N36E 2UXBE 1U2RA 4B3SE 4MDTA 5IT9Q 4MYUA 4P52A 4B3TE 4HACA 2UXDE 2Z5CB 1N36I 3PS1A 2UXBI 4LCFA 2V34A 4B3SI 3J7AM 3ZKDA 4LOMA 2IOQA 1FWKA 3F0NA 1HNXE 2UXDI 2UXCE 2J65A 1ZXMA 4FN5A 4OO1E 4HY1A 4IFDF 1I94E 4DV6I 3ZZTA 1Y5YA 4N3OA 2XEXA 1KIJA 1FNMA 1Z0VA 3CDIA 4DR2E 1HNXI 4DV2E 2UXCI 1IBKE 2X7IA 4IZKA 1Z0WA 4GQUA 2CG9A 4DXLA 1I94I 4DR3I 3PS3A 4DV3E 2IERA 2HFSA 5JEAF 4BA2B 4FW7A 1B63A 4LPFA 1IBKI 3M7ND 4Z7CA 2Z5EA 4DR7E 3B8HA 1NHHA 4DV3I 1N32E 2AE8A 1N33E 4K0KE 1S16A 1PKPA 3M85D 2HFUA 4HACB 1FKAE 4DR7I 2NPFA 4JI7E 3CDJA 1KTVA 1KVKA 4EMDA 1UDSA 3ZKBA 2AJ4A 4DR4E 3PYDA 2UUBE 1Y60A 5L3JA 4K0KI 1N33I 3JAMQ 4X64E 4OZEA 2GS8A 1XMOE 3J80C 4MYTA 4X62E 1EA6A 1FJGI 1UDNA 2UUBI 4WUDA 1XNRE 4JI2I 3ZZ0A 4X64I 3J81C 4LCGA 1Z0TA 4X62I 4RPFA 4IZKB 2PO2A 5K36E 1ZM2A 2HHHE 4M1KA 4JI4E 2VESA 2NN6C 2Z5CA 4DV4E 5C0XE 1XNRI 1H7SA 5K36D 2V8PA 1E3PA 3T1HE 3P76A 5C0XD 5LMUI 3T1YI 2VF3A 4GKJI 4DV7I 2GO4A 3PYFA 2E5LE 4MU3A 2HHHI 4JI4I 3KRNA 4DV4I 1UDOA 4JI1E 2O1VA 1UEKA 5DNXA 2NN6A 5DROA 5FLXC 4ED4A 2E5LI 4DV0E 2F1DA 4JG4A 1NHIA 3Q1QA 1IBLE 2JEBA 4JI1I 1BKNA 2BA0D 4B3RE 2BR2A 4LF4I 4ISAA 3K17A 3Q6NA 2HK2A 2UU9E 4LFAE 4PRVA 3CWVA 2PNLA 1HK7A 3ZM7A 5K36A 3QT5A 1R6LA 1IBLI 5C0XA 1Z5AA 3PS2A 4B3RI 4B3ME 3WU6A 3LTOA 1ZM4A 2HKJA 4LFAI 4BA1A 4LFBE 2PO2B 3HULA 3OTOE 2CVEA 1UDQA 1PIEA 2LJPA 4P7AA 4DPTA 4B3MI 1Z5BA 3V2UC 2BM0A 4AQYI 2OI2A 1H73A 4LFBI 4DPYA 4U3BA 4B3TI 1A6FA 1Z0CA 2JEAA 4IZJD 1IBME 1USUA 5GMEA 2BV3A 2NN6B 2ZM6E 3LNUA 4LF6E 4QNKA 1VISA 1Y6ZA 2R42A 3K85A 4MU1A 4NXME 4FW6A 2UUAE 1Z5CA 1XHKA 1R6MA 1YH8A 4JI3E 1XMQE 5A2QC 1N0VC 4LF7E 2JEBB 1RREA 1PVGA 4ZVIA 5FWKA 2ZM6I 4LF6I 2BR2B 1N34E 4NXMI 1XNQE 2UUAI 4DR2I 5K36B 4DV2I 1ZXNA 4DR6E 4IFDC 4OO1F 4JI3I 2F4VE 1XMQI 4LF7I 1VI7A 3GONA 1HNWE 5C0XB 1OYSA 3M7NG 3HJCA 1N34I 1HR0E 1XNQI 1ZM3A 1FI4A 4BA1B 4DR6I 4WUBA 4IZJA 3P06A 1HNWI 1WUUA 4IFDA 5GMDA 5JEAC 3M85G 3J80Q 1N32I 1HR0I 2GQ0A 1Y4SA 2NN6E 2J7KA 3WU4A 4JI6E 2HKEA 3B4TA 4JI7I 2NN6D 2JEAB 4JYAE 3LPSA 3J81Q 4DR4I 4OX9E 1MX0A 1OYPA 5LL6R 4AM3A 5JEAA 2ZBKB 3U1KA 5IWAE 3GLLA 2VQFE 1XMOI 4JI6I 4UT4A 2DEJA 2JT2A 4OX9I 2A2DA 1EI1A 1Y4UA 3QT6A 4IS9A 5IWAI 3P3GA 2C39A 1E3HA 4XTJA 4DR1E 2C37B 5DRRA 4FWGA 3PRYA 5FLXQ 2BA1D 1RR9A 5DRQA 2UUCE 4DPWA 3T1HI 1FWLA 1S4EA 2V2VA 4UTGA 4IZJB 1B62A 4DR1I 5K36F 1USVA 2WW4A 1OYRA 4DU7A 3DD6A 5C0XF 4IFDB 1DARA 3P3EA 2UUCI 1NHJA 2A2CA 5BR8E 4FW5A 4DV0I 4AIDA 4PRXA 2BA0G 2DEIA 2IESA 3GCMA 3P3CA 3WU5A 4USMA 2GO3A 5JEAB 1ELOA 5BR8I 3B78A 3U1YA 2UU9I 3PYEA 3HKMA 1H74A 4FWHA 2VQEE 3K1JA 4FW9A 2WNRA 4KHPE 2C39B 4OKGA 4QNJA 3WU3A 4YY3E 1ZM9A 2CGEA 3OTOI 1RHYA 2VQEI 2O1TA 4LF5E 4IFDE 3NZKA 1Z0EA 4KHPI 3Q6MA 3D4JA 5A2QQ 4YY3I 4IFDD 4HYMA 4FWDA 4JI8E 3ZZUA 3J7AG 3L7ZA 5IT9C 4DV5E 4LF5I 2C38A 4DV6E 4HXZA 1IBMI 4PU9A 5DRPA 4FW4A 3QT8A 3H1CA 4JI0E 4GKKE 5JEAE 4JI8I 2V2QA 1D6TA 4USKA 2WP8A 4DV5I 5JEAD 2C37A 4URLA 4MU4A 4DR3E 4OO1D 4LF8E 5LMNE 1K47A 1OJ4A 4JI0I 2ZITA 4GKKI 2O3ZA 4DU8A 1Z0BA 3B82A 2CZ9A 1N0UA 4KQVA 2F4VI 4JV5E 1MU5A 2JE6A 4LF8I 5LMNI 2WNRB 4LF9E 4OO1C 1Z59A 1J5EE 1HNZE 2PO0A 4J3DA 2EFGA 4JV5I 5EKWA 2BM1A 4DUYE 4LCHA 4DPXA 2X36A 4LF9I 4JI5E 2HK3A 1J5EI 3H4LA 4DUZE 1HNZI 4DV1E 4OO1A 3L7ZB 4DUYI 2PNZA 1P42A 1Z0GA 4JYAI 1FJGE 2E1RA 2C38B 2Z5BA 4DR5E 3V5RA 4JI5I 5DNLA 4LFCE 4JI2E 2NN6F 4YHHE 4DUZI 1YHCA 4NXNE 4X66E 2VQFI 4DV1I 2WP8B
chains in the Genus database with same CATH topology
2J65A 5DRRA 4LCHA 5DRQA 2IESA 3PS2A 4MQYA 4U3DA 3P3CA 3NZKA 2GO3A 4FW3A 5DROA 2O3ZA 3U1YA 4MDTA 4LCGA 4FW6A 3UHMA 1XXEA 1YH8A 1P42A 2JT2A 2VESA 3P3EA 3PS3A 3PS1A 5DRPA 4LCFA 2IERA 4FW4A 4IS9A 4ISAA 1YHCA 3P3GA 3P76A 4FW7A 4OKGA 4OZEA 4FW5A 4J3DA 4U3BA 2GO4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J65 A;  5DRR A;  4LCH A;  5DRQ A;  2IES A;  3PS2 A;  4MQY A;  4U3D A;  3P3C A;  3NZK A;  2GO3 A;  4FW3 A;  5DRO A;  2O3Z A;  3U1Y A;  4MDT A;  4LCG A;  4FW6 A;  3UHM A;  1XXE A;  1YH8 A;  1P42 A;  2JT2 A;  2VES A;  3P3E A;  3PS3 A;  3PS1 A;  5DRP A;  4LCF A;  2IER A;  4FW4 A;  4IS9 A;  4ISA A;  1YHC A;  3P3G A;  3P76 A;  4FW7 A;  4OKG A;  4OZE A;  4FW5 A;  4J3D A;  4U3B A;  2GO4 A; 
#chains in the Genus database with same CATH topology
 3JAM C;  1H72 C;  2PNM A;  4DR5 I;  2PO1 A;  4LFC I;  4MQY A;  4U3D A;  4YHH I;  2R3V A;  4NXN I;  2V2Z A;  4X66 I;  5LMU E;  1KKH A;  3T1Y E;  4GKJ E;  3UHM A;  4DV7 E;  2BA1 G;  3PYG A;  3M6A A;  3GME A;  2JE6 B;  4Z7Y A;  5EL9 A;  5ELW A;  2PO0 B;  4NBQ A;  4AIM A;  4LF4 E;  4FW3 A;  2O1U A;  5K36 C;  2IOP A;  4MU0 A;  1QZR A;  5C0X C;  4OO1 B;  1XXE A;  1NZ0 A;  1H7U A;  2PNZ B;  4X65 E;  4WUC A;  2O1W A;  2Z5B B;  3QT7 A;  4DPU A;  4R1F A;  4BA2 A;  2Q2E B;  4X65 I;  4I3H A;  2PO1 B;  1MG7 A;  4AQY E;  1N36 E;  2UXB E;  1U2R A;  4B3S E;  4MDT A;  5IT9 Q;  4MYU A;  4P52 A;  4B3T E;  4HAC A;  2UXD E;  2Z5C B;  1N36 I;  3PS1 A;  2UXB I;  4LCF A;  2V34 A;  4B3S I;  3J7A M;  3ZKD A;  4LOM A;  2IOQ A;  1FWK A;  3F0N A;  1HNX E;  2UXD I;  2UXC E;  2J65 A;  1ZXM A;  4FN5 A;  4OO1 E;  4HY1 A;  4IFD F;  1I94 E;  4DV6 I;  3ZZT A;  1Y5Y A;  4N3O A;  2XEX A;  1KIJ A;  1FNM A;  1Z0V A;  3CDI A;  4DR2 E;  1HNX I;  4DV2 E;  2UXC I;  1IBK E;  2X7I A;  4IZK A;  1Z0W A;  4GQU A;  2CG9 A;  4DXL A;  1I94 I;  4DR3 I;  3PS3 A;  4DV3 E;  2IER A;  2HFS A;  5JEA F;  4BA2 B;  4FW7 A;  1B63 A;  4LPF A;  1IBK I;  3M7N D;  4Z7C A;  2Z5E A;  4DR7 E;  3B8H A;  1NHH A;  4DV3 I;  1N32 E;  2AE8 A;  1N33 E;  4K0K E;  1S16 A;  1PKP A;  3M85 D;  2HFU A;  4HAC B;  1FKA E;  4DR7 I;  2NPF A;  4JI7 E;  3CDJ A;  1KTV A;  1KVK A;  4EMD A;  1UDS A;  3ZKB A;  2AJ4 A;  4DR4 E;  3PYD A;  2UUB E;  1Y60 A;  5L3J A;  4K0K I;  1N33 I;  3JAM Q;  4X64 E;  4OZE A;  2GS8 A;  1XMO E;  3J80 C;  4MYT A;  4X62 E;  1EA6 A;  1FJG I;  1UDN A;  2UUB I;  4WUD A;  1XNR E;  4JI2 I;  3ZZ0 A;  4X64 I;  3J81 C;  4LCG A;  1Z0T A;  4X62 I;  4RPF A;  4IZK B;  2PO2 A;  5K36 E;  1ZM2 A;  2HHH E;  4M1K A;  4JI4 E;  2VES A;  2NN6 C;  2Z5C A;  4DV4 E;  5C0X E;  1XNR I;  1H7S A;  5K36 D;  2V8P A;  1E3P A;  3T1H E;  3P76 A;  5C0X D;  5LMU I;  3T1Y I;  2VF3 A;  4GKJ I;  4DV7 I;  2GO4 A;  3PYF A;  2E5L E;  4MU3 A;  2HHH I;  4JI4 I;  3KRN A;  4DV4 I;  1UDO A;  4JI1 E;  2O1V A;  1UEK A;  5DNX A;  2NN6 A;  5DRO A;  5FLX C;  4ED4 A;  2E5L I;  4DV0 E;  2F1D A;  4JG4 A;  1NHI A;  3Q1Q A;  1IBL E;  2JEB A;  4JI1 I;  1BKN A;  2BA0 D;  4B3R E;  2BR2 A;  4LF4 I;  4ISA A;  3K17 A;  3Q6N A;  2HK2 A;  2UU9 E;  4LFA E;  4PRV A;  3CWV A;  2PNL A;  1HK7 A;  3ZM7 A;  5K36 A;  3QT5 A;  1R6L A;  1IBL I;  5C0X A;  1Z5A A;  3PS2 A;  4B3R I;  4B3M E;  3WU6 A;  3LTO A;  1ZM4 A;  2HKJ A;  4LFA I;  4BA1 A;  4LFB E;  2PO2 B;  3HUL A;  3OTO E;  2CVE A;  1UDQ A;  1PIE A;  2LJP A;  4P7A A;  4DPT A;  4B3M I;  1Z5B A;  3V2U C;  2BM0 A;  4AQY I;  2OI2 A;  1H73 A;  4LFB I;  4DPY A;  4U3B A;  4B3T I;  1A6F A;  1Z0C A;  2JEA A;  4IZJ D;  1IBM E;  1USU A;  5GME A;  2BV3 A;  2NN6 B;  2ZM6 E;  3LNU A;  4LF6 E;  4QNK A;  1VIS A;  1Y6Z A;  2R42 A;  3K85 A;  4MU1 A;  4NXM E;  4FW6 A;  2UUA E;  1Z5C A;  1XHK A;  1R6M A;  1YH8 A;  4JI3 E;  1XMQ E;  5A2Q C;  1N0V C;  4LF7 E;  2JEB B;  1RRE A;  1PVG A;  4ZVI A;  5FWK A;  2ZM6 I;  4LF6 I;  2BR2 B;  1N34 E;  4NXM I;  1XNQ E;  2UUA I;  4DR2 I;  5K36 B;  4DV2 I;  1ZXN A;  4DR6 E;  4IFD C;  4OO1 F;  4JI3 I;  2F4V E;  1XMQ I;  4LF7 I;  1VI7 A;  3GON A;  1HNW E;  5C0X B;  1OYS A;  3M7N G;  3HJC A;  1N34 I;  1HR0 E;  1XNQ I;  1ZM3 A;  1FI4 A;  4BA1 B;  4DR6 I;  4WUB A;  4IZJ A;  3P06 A;  1HNW I;  1WUU A;  4IFD A;  5GMD A;  5JEA C;  3M85 G;  3J80 Q;  1N32 I;  1HR0 I;  2GQ0 A;  1Y4S A;  2NN6 E;  2J7K A;  3WU4 A;  4JI6 E;  2HKE A;  3B4T A;  4JI7 I;  2NN6 D;  2JEA B;  4JYA E;  3LPS A;  3J81 Q;  4DR4 I;  4OX9 E;  1MX0 A;  1OYP A;  5LL6 R;  4AM3 A;  5JEA A;  2ZBK B;  3U1K A;  5IWA E;  3GLL A;  2VQF E;  1XMO I;  4JI6 I;  4UT4 A;  2DEJ A;  2JT2 A;  4OX9 I;  2A2D A;  1EI1 A;  1Y4U A;  3QT6 A;  4IS9 A;  5IWA I;  3P3G A;  2C39 A;  1E3H A;  4XTJ A;  4DR1 E;  2C37 B;  5DRR A;  4FWG A;  3PRY A;  5FLX Q;  2BA1 D;  1RR9 A;  5DRQ A;  2UUC E;  4DPW A;  3T1H I;  1FWL A;  1S4E A;  2V2V A;  4UTG A;  4IZJ B;  1B62 A;  4DR1 I;  5K36 F;  1USV A;  2WW4 A;  1OYR A;  4DU7 A;  3DD6 A;  5C0X F;  4IFD B;  1DAR A;  3P3E A;  2UUC I;  1NHJ A;  2A2C A;  5BR8 E;  4FW5 A;  4DV0 I;  4AID A;  4PRX A;  2BA0 G;  2DEI A;  2IES A;  3GCM A;  3P3C A;  3WU5 A;  4USM A;  2GO3 A;  5JEA B;  1ELO A;  5BR8 I;  3B78 A;  3U1Y A;  2UU9 I;  3PYE A;  3HKM A;  1H74 A;  4FWH A;  2VQE E;  3K1J A;  4FW9 A;  2WNR A;  4KHP E;  2C39 B;  4OKG A;  4QNJ A;  3WU3 A;  4YY3 E;  1ZM9 A;  2CGE A;  3OTO I;  1RHY A;  2VQE I;  2O1T A;  4LF5 E;  4IFD E;  3NZK A;  1Z0E A;  4KHP I;  3Q6M A;  3D4J A;  5A2Q Q;  4YY3 I;  4IFD D;  4HYM A;  4FWD A;  4JI8 E;  3ZZU A;  3J7A G;  3L7Z A;  5IT9 C;  4DV5 E;  4LF5 I;  2C38 A;  4DV6 E;  4HXZ A;  1IBM I;  4PU9 A;  5DRP A;  4FW4 A;  3QT8 A;  3H1C A;  4JI0 E;  4GKK E;  5JEA E;  4JI8 I;  2V2Q A;  1D6T A;  4USK A;  2WP8 A;  4DV5 I;  5JEA D;  2C37 A;  4URL A;  4MU4 A;  4DR3 E;  4OO1 D;  4LF8 E;  5LMN E;  1K47 A;  1OJ4 A;  4JI0 I;  2ZIT A;  4GKK I;  2O3Z A;  4DU8 A;  1Z0B A;  3B82 A;  2CZ9 A;  1N0U A;  4KQV A;  2F4V I;  4JV5 E;  1MU5 A;  2JE6 A;  4LF8 I;  5LMN I;  2WNR B;  4LF9 E;  4OO1 C;  1Z59 A;  1J5E E;  1HNZ E;  2PO0 A;  4J3D A;  2EFG A;  4JV5 I;  5EKW A;  2BM1 A;  4DUY E;  4LCH A;  4DPX A;  2X36 A;  4LF9 I;  4JI5 E;  2HK3 A;  1J5E I;  3H4L A;  4DUZ E;  1HNZ I;  4DV1 E;  4OO1 A;  3L7Z B;  4DUY I;  2PNZ A;  1P42 A;  1Z0G A;  4JYA I;  1FJG E;  2E1R A;  2C38 B;  2Z5B A;  4DR5 E;  3V5R A;  4JI5 I;  5DNL A;  4LFC E;  4JI2 E;  2NN6 F;  4YHH E;  4DUZ I;  1YHC A;  4NXN E;  4X66 E;  2VQF I;  4DV1 I;  2WP8 B; 
#chains in the Genus database with same CATH homology
 2J65 A;  5DRR A;  4LCH A;  5DRQ A;  2IES A;  3PS2 A;  4MQY A;  4U3D A;  3P3C A;  3NZK A;  2GO3 A;  4FW3 A;  5DRO A;  2O3Z A;  3U1Y A;  4MDT A;  4LCG A;  4FW6 A;  3UHM A;  1XXE A;  1YH8 A;  1P42 A;  2JT2 A;  2VES A;  3P3E A;  3PS3 A;  3PS1 A;  5DRP A;  4LCF A;  2IER A;  4FW4 A;  4IS9 A;  4ISA A;  1YHC A;  3P3G A;  3P76 A;  4FW7 A;  4OKG A;  4OZE A;  4FW5 A;  4J3D A;  4U3B A;  2GO4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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