4LPFA

Crystal structure of mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
190
structure length
190
Chain Sequence
SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of the native, substrate- bound and inhibited forms of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase
rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis h37rv
molecule keywords Imidazoleglycerol-phosphate dehydratase
total genus 60
structure length 190
sequence length 190
ec nomenclature ec 4.2.1.19: Imidazoleglycerol-phosphate dehydratase.
pdb deposition date 2013-07-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.40 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 Imidazole glycerol phosphate dehydratase; domain 1 4lpfA01
3.30.230.40 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 Imidazole glycerol phosphate dehydratase; domain 1 4lpfA02
4MU4A 5ELWA 5EL9A 4LPFA 4MU1A 5DNXA 4LOMA 5EKWA 4QNJA 1RHYA 4MU3A 2AE8A 4GQUA 2F1DA 4MU0A 5DNLA 4QNKA
chains in the Genus database with same CATH superfamily
4DR2E 3OTOI 4IZJB 3D4JA 5K36A 4JI5I 2Z5CA 4HACA 1HNZI 1HK7A 4B3ME 1Y4SA 4DR2I 3KRNA 1J5EI 5LMNI 1PKPA 4MU0A 4JI1E 4IFDE 2A2CA 2HFSA 1I94I 4B3MI 4DR4E 4N3OA 4GKKI 4DUZE 4LF9E 5C0XF 4DU7A 2A2DA 2J65A 3M85D 3ZZ0A 4AQYE 4LCGA 4JI6E 4DUZI 4MU1A 4LFCE 3PYFA 1Z0CA 3GONA 5ELWA 4DPTA 3HJCA 1A6FA 2BR2B 1HNWE 4JI6I 5C0XE 2NN6B 3NZKA 1IBKI 1H7SA 5GMDA 1YH8A 5EL9A 1XMOE 4WUCA 4BA1B 1Z0VA 3CWVA 2AE8A 1N32I 3QT8A 2HKJA 4OO1C 4DV4I 2UUCI 4HY1A 4HXZA 2O1VA 5GMEA 4NBQA 2UXDI 2WP8B 2HHHE 2BR2A 2NN6A 3PYDA 4FW7A 5IWAE 4DPWA 4K0KI 1N36I 1R6LA 4MYTA 2UXCI 2F4VE 1UEKA 2HHHI 1S4EA 4OX9E 1H73A 4X66E 4PRXA 4MYUA 4KHPI 2VQEI 2JE6B 1E3HA 2NN6F 4JV5E 2O1TA 2Q2EB 3QT5A 4LFAI 1OYRA 2X7IA 3UHMA 4DR6I 2BV3A 2WP8A 4YHHE 2UU9I 4DR7I 5JEAB 2Z5EA 4BA2B 4FWDA 1D6TA 2OI2A 3U1KA 4DV6I 3WU5A 2V2VA 4DV7E 2JE6A 2JEAB 4LF8E 2O1UA 1IBLE 4JI8I 4YY3E 3M85G 1Z5AA 4DV7I 1Z59A 1N33I 4USKA 5JEAA 1U2RA 1Z0TA 1ELOA 4DV5E 2ZBKB 2ZM6E 4BA2A 4GKJI 2HFUA 4LF5I 4LF7I 3P06A 1OYSA 2PO2B 2C38B 2JEAA 2Z5BB 4DV0I 5K36C 4JG4A 3PS2A 1USUA 4JI4E 4DR3E 4DV1I 1H72C 3JAMC 2IERA 1DARA 1E3PA 1ZM4A 1USVA 4Z7CA 5C0XB 2GS8A 2PO2A 4LFBE 2C38A 2UUAI 2Z5BA 3OTOE 4OO1E 2ZITA 3J81Q 1HNZE 4IFDF 4UTGA 4OZEA 4UT4A 2V34A 4ED4A 1J5EE 2PNZB 2E1RA 3K17A 5LMNE 4GQUA 4AM3A 3F0NA 4Z7YA 2BM0A 4IZJD 4OKGA 1I94E 5C0XA 3PS1A 4GKKE 1BKNA 4P52A 2IOPA 4DU8A 1XMQI 1HR0I 2V8PA 1UDQA 4B3TI 3K1JA 4U3BA 4P7AA 2EFGA 3B82A 4IZJA 2PNZA 4DUYI 5LMUI 2BA0G 1IBKE 4PU9A 1PIEA 2UXBI 4MU4A 4AIDA 2CVEA 3CDJA 2HK3A 4EMDA 4B3RI 4LF4E 5DROA 2X36A 1H7UA 5DRPA 1N32E 2BM1A 4FN5A 4DV4E 2HK2A 2NN6D 2UUCE 4JYAI 5FWKA 4FW3A 2UXDE 4LF4I 4LF6I 3H1CA 2XEXA 4URLA 3K85A 5EKWA 4K0KE 1N36E 2UXCE 5FLXQ 5K36E 4X64I 2O1WA 4FW6A 3PYGA 4X65I 1VI7A 2VQEE 4KHPE 2DEIA 4DR5I 5FLXC 3CDIA 4FWGA 4AIMA 4LFAE 1Z0WA 4BA1A 4DR6E 5DNXA 5JEAC 4JI0I 2UU9E 1XNQE 4DR7E 4LPFA 4LOMA 1KVKA 1UDNA 2JT2A 1OJ4A 4M1KA 3LNUA 3ZKBA 1XNQI 4DV6E 1B63A 5DRQA 4B3SI 2E5LI 5JEAD 3WU4A 4X62I 4JI8E 1UDOA 2PNLA 1ZM3A 1IBMI 1N33E 3PS3A 2UUBI 4PRVA 4LCHA 4NXMI 1MX0A 3LPSA 4IS9A 4GKJE 1FI4A 4LF5E 4LF7E 4FW4A 1XNRI 4KQVA 3T1YI 2CG9A 2BA0D 3V2UC 3B78A 1Y4UA 4DXLA 4DV0E 3B4TA 4IFDB 2V2ZA 4ISAA 4IFDD 4R1FA 4DV1E 1ZM2A 2PNMA 4WUBA 1NHHA 4MDTA 4OO1F 3ZZTA 3HULA 5C0XC 2UUAE 2J7KA 4IFDA 1FJGI 2GO4A 3P76A 1Y60A 4DPUA 4JI7I 5C0XD 1N0VC 4FWHA 2IESA 5L3JA 5BR8E 3LTOA 5DRRA 3WU3A 3T1HI 2IOQA 2VQFI 2PO1B 5BR8I 4ZVIA 2GQ0A 3J81C 4NXNI 3H4LA 1XMQE 1NZ0A 1HR0E 4B3TE 1HNXI 1P42A 4MQYA 1NHIA 4DUYE 4DR1I 4QNJA 1EA6A 2PO0B 5LMUE 3B8HA 2PO1A 4DV2I 3L7ZB 2UXBE 2O3ZA 1FWKA 1YHCA 2NN6C 1OYPA 4B3RE 1RHYA 1N34I 2LJPA 4QNKA 1FNMA 2BA1G 3M6AA 4JI3E 4JYAE 4LF6E 5K36F 2PO0A 3DD6A 3L7ZA 4JI3I 2C39B 4JI1I 1RREA 4DR4I 4DPXA 4X64E 2R3VA 4X65E 4LF9I 4DR5E 3GMEA 1XHKA 3Q1QA 1FWLA 3V5RA 3PYEA 4AQYI 4JI0E 3GLLA 3M7NG 4WUDA 4USMA 1Z5CA 4LFCI 1KIJA 2CZ9A 2C39A 2HKEA 1R6MA 2AJ4A 1HNWI 3ZKDA 3HKMA 1Z0BA 4DV3E 3Q6MA 5DNLA 3J80Q 4B3SE 2E5LE 3PRYA 1XMOI 2V2QA 4X62E 1PVGA 3P3CA 3P3GA 4DV3I 1IBME 2UUBE 3J80C 1FKAE 4NXME 1ZM9A 1UDSA 4OO1B 1H74A 1MU5A 1EI1A 3ZM7A 4OO1D 2CGEA 1KKHA 3QT7A 5IWAI 4MU3A 3T1YE 1XNRE 2F4VI 4IFDC 3QT6A 1KTVA 4OX9I 4X66I 1QZRA 3GCMA 4JV5I 4OO1A 1ZXNA 3P3EA 5A2QQ 4J3DA 5LL6R 4YHHI 2BA1D 1VISA 4FW5A 4U3DA 4I3HA 2NN6E 3Q6NA 1Y5YA 1Z5BA 5IT9Q 5A2QC 4HYMA 2JEBB 1FJGE 1RR9A 1S16A 4JI7E 5IT9C 1Z0EA 4XTJA 4LF8I 2VF3A 2C37B 2DEJA 1IBLI 3U1YA 4YY3I 3WU6A 3J7AM 4RPFA 3T1HE 2NPFA 1ZXMA 3ZZUA 2WW4A 3J7AG 2VQFE 4DV5I 2ZM6I 3M7ND 5JEAF 1XXEA 2WNRB 2JEBA 3JAMQ 4NXNE 4IZKB 4DPYA 4JI2E 4FW9A 1K47A 1Y6ZA 1HNXE 2C37A 1MG7A 5K36B 2Z5CB 2GO3A 4HACB 4DR1E 4JI2I 2F1DA 4JI4I 1Z0GA 5JEAE 4DR3I 2VESA 5K36D 4LCFA 4DV2E 2R42A 2WNRA 1B62A 1N0UA 1NHJA 4JI5E 4IZKA 1WUUA 1N34E 4LFBI
chains in the Genus database with same CATH topology
4MU4A 5ELWA 5EL9A 4LPFA 4MU1A 5DNXA 4LOMA 5EKWA 4QNJA 1RHYA 4MU3A 2AE8A 4GQUA 2F1DA 4MU0A 5DNLA 4QNKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MU4 A;  5ELW A;  5EL9 A;  4LPF A;  4MU1 A;  5DNX A;  4LOM A;  5EKW A;  4QNJ A;  1RHY A;  4MU3 A;  2AE8 A;  4GQU A;  2F1D A;  4MU0 A;  5DNL A;  4QNK A; 
#chains in the Genus database with same CATH topology
 4DR2 E;  3OTO I;  4IZJ B;  3D4J A;  5K36 A;  4JI5 I;  2Z5C A;  4HAC A;  1HNZ I;  1HK7 A;  4B3M E;  1Y4S A;  4DR2 I;  3KRN A;  1J5E I;  5LMN I;  1PKP A;  4MU0 A;  4JI1 E;  4IFD E;  2A2C A;  2HFS A;  1I94 I;  4B3M I;  4DR4 E;  4N3O A;  4GKK I;  4DUZ E;  4LF9 E;  5C0X F;  4DU7 A;  2A2D A;  2J65 A;  3M85 D;  3ZZ0 A;  4AQY E;  4LCG A;  4JI6 E;  4DUZ I;  4MU1 A;  4LFC E;  3PYF A;  1Z0C A;  3GON A;  5ELW A;  4DPT A;  3HJC A;  1A6F A;  2BR2 B;  1HNW E;  4JI6 I;  5C0X E;  2NN6 B;  3NZK A;  1IBK I;  1H7S A;  5GMD A;  1YH8 A;  5EL9 A;  1XMO E;  4WUC A;  4BA1 B;  1Z0V A;  3CWV A;  2AE8 A;  1N32 I;  3QT8 A;  2HKJ A;  4OO1 C;  4DV4 I;  2UUC I;  4HY1 A;  4HXZ A;  2O1V A;  5GME A;  4NBQ A;  2UXD I;  2WP8 B;  2HHH E;  2BR2 A;  2NN6 A;  3PYD A;  4FW7 A;  5IWA E;  4DPW A;  4K0K I;  1N36 I;  1R6L A;  4MYT A;  2UXC I;  2F4V E;  1UEK A;  2HHH I;  1S4E A;  4OX9 E;  1H73 A;  4X66 E;  4PRX A;  4MYU A;  4KHP I;  2VQE I;  2JE6 B;  1E3H A;  2NN6 F;  4JV5 E;  2O1T A;  2Q2E B;  3QT5 A;  4LFA I;  1OYR A;  2X7I A;  3UHM A;  4DR6 I;  2BV3 A;  2WP8 A;  4YHH E;  2UU9 I;  4DR7 I;  5JEA B;  2Z5E A;  4BA2 B;  4FWD A;  1D6T A;  2OI2 A;  3U1K A;  4DV6 I;  3WU5 A;  2V2V A;  4DV7 E;  2JE6 A;  2JEA B;  4LF8 E;  2O1U A;  1IBL E;  4JI8 I;  4YY3 E;  3M85 G;  1Z5A A;  4DV7 I;  1Z59 A;  1N33 I;  4USK A;  5JEA A;  1U2R A;  1Z0T A;  1ELO A;  4DV5 E;  2ZBK B;  2ZM6 E;  4BA2 A;  4GKJ I;  2HFU A;  4LF5 I;  4LF7 I;  3P06 A;  1OYS A;  2PO2 B;  2C38 B;  2JEA A;  2Z5B B;  4DV0 I;  5K36 C;  4JG4 A;  3PS2 A;  1USU A;  4JI4 E;  4DR3 E;  4DV1 I;  1H72 C;  3JAM C;  2IER A;  1DAR A;  1E3P A;  1ZM4 A;  1USV A;  4Z7C A;  5C0X B;  2GS8 A;  2PO2 A;  4LFB E;  2C38 A;  2UUA I;  2Z5B A;  3OTO E;  4OO1 E;  2ZIT A;  3J81 Q;  1HNZ E;  4IFD F;  4UTG A;  4OZE A;  4UT4 A;  2V34 A;  4ED4 A;  1J5E E;  2PNZ B;  2E1R A;  3K17 A;  5LMN E;  4GQU A;  4AM3 A;  3F0N A;  4Z7Y A;  2BM0 A;  4IZJ D;  4OKG A;  1I94 E;  5C0X A;  3PS1 A;  4GKK E;  1BKN A;  4P52 A;  2IOP A;  4DU8 A;  1XMQ I;  1HR0 I;  2V8P A;  1UDQ A;  4B3T I;  3K1J A;  4U3B A;  4P7A A;  2EFG A;  3B82 A;  4IZJ A;  2PNZ A;  4DUY I;  5LMU I;  2BA0 G;  1IBK E;  4PU9 A;  1PIE A;  2UXB I;  4MU4 A;  4AID A;  2CVE A;  3CDJ A;  2HK3 A;  4EMD A;  4B3R I;  4LF4 E;  5DRO A;  2X36 A;  1H7U A;  5DRP A;  1N32 E;  2BM1 A;  4FN5 A;  4DV4 E;  2HK2 A;  2NN6 D;  2UUC E;  4JYA I;  5FWK A;  4FW3 A;  2UXD E;  4LF4 I;  4LF6 I;  3H1C A;  2XEX A;  4URL A;  3K85 A;  5EKW A;  4K0K E;  1N36 E;  2UXC E;  5FLX Q;  5K36 E;  4X64 I;  2O1W A;  4FW6 A;  3PYG A;  4X65 I;  1VI7 A;  2VQE E;  4KHP E;  2DEI A;  4DR5 I;  5FLX C;  3CDI A;  4FWG A;  4AIM A;  4LFA E;  1Z0W A;  4BA1 A;  4DR6 E;  5DNX A;  5JEA C;  4JI0 I;  2UU9 E;  1XNQ E;  4DR7 E;  4LPF A;  4LOM A;  1KVK A;  1UDN A;  2JT2 A;  1OJ4 A;  4M1K A;  3LNU A;  3ZKB A;  1XNQ I;  4DV6 E;  1B63 A;  5DRQ A;  4B3S I;  2E5L I;  5JEA D;  3WU4 A;  4X62 I;  4JI8 E;  1UDO A;  2PNL A;  1ZM3 A;  1IBM I;  1N33 E;  3PS3 A;  2UUB I;  4PRV A;  4LCH A;  4NXM I;  1MX0 A;  3LPS A;  4IS9 A;  4GKJ E;  1FI4 A;  4LF5 E;  4LF7 E;  4FW4 A;  1XNR I;  4KQV A;  3T1Y I;  2CG9 A;  2BA0 D;  3V2U C;  3B78 A;  1Y4U A;  4DXL A;  4DV0 E;  3B4T A;  4IFD B;  2V2Z A;  4ISA A;  4IFD D;  4R1F A;  4DV1 E;  1ZM2 A;  2PNM A;  4WUB A;  1NHH A;  4MDT A;  4OO1 F;  3ZZT A;  3HUL A;  5C0X C;  2UUA E;  2J7K A;  4IFD A;  1FJG I;  2GO4 A;  3P76 A;  1Y60 A;  4DPU A;  4JI7 I;  5C0X D;  1N0V C;  4FWH A;  2IES A;  5L3J A;  5BR8 E;  3LTO A;  5DRR A;  3WU3 A;  3T1H I;  2IOQ A;  2VQF I;  2PO1 B;  5BR8 I;  4ZVI A;  2GQ0 A;  3J81 C;  4NXN I;  3H4L A;  1XMQ E;  1NZ0 A;  1HR0 E;  4B3T E;  1HNX I;  1P42 A;  4MQY A;  1NHI A;  4DUY E;  4DR1 I;  4QNJ A;  1EA6 A;  2PO0 B;  5LMU E;  3B8H A;  2PO1 A;  4DV2 I;  3L7Z B;  2UXB E;  2O3Z A;  1FWK A;  1YHC A;  2NN6 C;  1OYP A;  4B3R E;  1RHY A;  1N34 I;  2LJP A;  4QNK A;  1FNM A;  2BA1 G;  3M6A A;  4JI3 E;  4JYA E;  4LF6 E;  5K36 F;  2PO0 A;  3DD6 A;  3L7Z A;  4JI3 I;  2C39 B;  4JI1 I;  1RRE A;  4DR4 I;  4DPX A;  4X64 E;  2R3V A;  4X65 E;  4LF9 I;  4DR5 E;  3GME A;  1XHK A;  3Q1Q A;  1FWL A;  3V5R A;  3PYE A;  4AQY I;  4JI0 E;  3GLL A;  3M7N G;  4WUD A;  4USM A;  1Z5C A;  4LFC I;  1KIJ A;  2CZ9 A;  2C39 A;  2HKE A;  1R6M A;  2AJ4 A;  1HNW I;  3ZKD A;  3HKM A;  1Z0B A;  4DV3 E;  3Q6M A;  5DNL A;  3J80 Q;  4B3S E;  2E5L E;  3PRY A;  1XMO I;  2V2Q A;  4X62 E;  1PVG A;  3P3C A;  3P3G A;  4DV3 I;  1IBM E;  2UUB E;  3J80 C;  1FKA E;  4NXM E;  1ZM9 A;  1UDS A;  4OO1 B;  1H74 A;  1MU5 A;  1EI1 A;  3ZM7 A;  4OO1 D;  2CGE A;  1KKH A;  3QT7 A;  5IWA I;  4MU3 A;  3T1Y E;  1XNR E;  2F4V I;  4IFD C;  3QT6 A;  1KTV A;  4OX9 I;  4X66 I;  1QZR A;  3GCM A;  4JV5 I;  4OO1 A;  1ZXN A;  3P3E A;  5A2Q Q;  4J3D A;  5LL6 R;  4YHH I;  2BA1 D;  1VIS A;  4FW5 A;  4U3D A;  4I3H A;  2NN6 E;  3Q6N A;  1Y5Y A;  1Z5B A;  5IT9 Q;  5A2Q C;  4HYM A;  2JEB B;  1FJG E;  1RR9 A;  1S16 A;  4JI7 E;  5IT9 C;  1Z0E A;  4XTJ A;  4LF8 I;  2VF3 A;  2C37 B;  2DEJ A;  1IBL I;  3U1Y A;  4YY3 I;  3WU6 A;  3J7A M;  4RPF A;  3T1H E;  2NPF A;  1ZXM A;  3ZZU A;  2WW4 A;  3J7A G;  2VQF E;  4DV5 I;  2ZM6 I;  3M7N D;  5JEA F;  1XXE A;  2WNR B;  2JEB A;  3JAM Q;  4NXN E;  4IZK B;  4DPY A;  4JI2 E;  4FW9 A;  1K47 A;  1Y6Z A;  1HNX E;  2C37 A;  1MG7 A;  5K36 B;  2Z5C B;  2GO3 A;  4HAC B;  4DR1 E;  4JI2 I;  2F1D A;  4JI4 I;  1Z0G A;  5JEA E;  4DR3 I;  2VES A;  5K36 D;  4LCF A;  4DV2 E;  2R42 A;  2WNR A;  1B62 A;  1N0U A;  1NHJ A;  4JI5 E;  4IZK A;  1WUU A;  1N34 E;  4LFB I; 
#chains in the Genus database with same CATH homology
 4MU4 A;  5ELW A;  5EL9 A;  4LPF A;  4MU1 A;  5DNX A;  4LOM A;  5EKW A;  4QNJ A;  1RHY A;  4MU3 A;  2AE8 A;  4GQU A;  2F1D A;  4MU0 A;  5DNL A;  4QNK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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