4FW3A

Crystal structure of the lpxc in complex with n-[(2s)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide inhibitor
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
302
structure length
302
Chain Sequence
SNAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the LpxC
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Pseudomonas aeruginosa
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 88
structure length 302
sequence length 302
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw3A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw3A02
1YH8A 2IESA 4FW4A 2JT2A 4LCGA 4FW5A 2GO4A 3PS3A 4LCFA 3PS2A 4ISAA 3P3GA 3U1YA 4FW3A 1P42A 2O3ZA 4OZEA 2IERA 5DROA 4LCHA 4FW7A 3P3EA 3P3CA 3NZKA 3P76A 1YHCA 2VESA 4MDTA 4U3DA 3PS1A 5DRRA 4FW6A 1XXEA 4MQYA 4U3BA 5DRQA 4IS9A 2J65A 2GO3A 5DRPA 3UHMA 4J3DA 4OKGA
chains in the Genus database with same CATH superfamily
4B3ME 5FWKA 5LMUE 5EKWA 2UUCI 4DPUA 4DR3E 2E1RA 4OO1B 4DUYI 2UXCI 1DARA 1KVKA 1FNMA 4IZKA 1HNWI 1FWKA 2F1DA 2VESA 1UDSA 3PRYA 1H7UA 4YY3E 4U3BA 3T1HI 4DPXA 1FWLA 1R6LA 1H74A 4FW9A 1XNQI 3J81C 3T1YI 4BA2A 3K85A 4LCFA 4JI8I 4X64I 5IWAI 3WU4A 4K0KE 4MU3A 4DV3I 4DV3E 4NBQA 1NHHA 4LF4I 3GLLA 3F0NA 4LF4E 2UU9I 4KHPI 4KHPE 4MU4A 4OO1D 4IZKB 4UTGA 4NXMI 4NXME 4JV5E 4DV2E 3L7ZA 2F4VI 3QT5A 3WU6A 1A6FA 2CVEA 2DEJA 4LF7E 1Z5CA 3J81Q 4QNJA 4GKKE 5K36A 1RREA 2JT2A 2HFUA 5DNLA 4KQVA 4X65I 2VQEE 4DV4E 4BA2B 4LF5I 4PRXA 3H4LA 2IERA 2GQ0A 1Z5AA 2VQFI 1N0UA 1EA6A 2UUBE 1J5EE 5JEAE 1IBLE 2NN6A 2WNRA 4X66I 2PNMA 4X66E 2PO2A 4YHHE 5C0XB 2J65A 3CDIA 4X62I 1FJGI 4ZVIA 1WUUA 3L7ZB 4JI3I 4JI3E 1N33E 3M7ND 2CG9A 5C0XF 4M1KA 1HNXE 3WU5A 4DV6I 1ZM9A 2JE6A 1N32I 5JEAC 2LJPA 3D4JA 1P42A 1IBKI 4IFDA 1UDOA 1IBKE 4DR6E 2BM0A 4JG4A 1FI4A 4HY1A 2JEBA 3CWVA 4DV7I 1Y4SA 4DR5E 1U2RA 3J7AG 5DNXA 1RR9A 3J80C 2NN6B 2WNRB 4LFAI 5DRPA 1QZRA 2PO2B 3LNUA 1NHIA 4JI7E 3ZM7A 3M85D 2PO1A 4DV0I 2V8PA 4DR2I 4DV0E 1MG7A 4FW4A 5GMDA 4PU9A 2NN6F 4EMDA 5C0XD 1XNRE 2O1VA 2HHHE 3P3GA 2UXBE 5JEAF 2V2ZA 2IOQA 2HKEA 4MU0A 4LCHA 2JE6B 1FKAE 4IFDB 1IBME 4LFBI 1XMOI 2JEBB 3B78A 1N34I 1EI1A 4IZJD 2NPFA 3J80Q 2V34A 2GS8A 4JI4I 4AIDA 1YH8A 2BM1A 3PYFA 4LCGA 4P52A 1N36E 2Z5BB 4DV1E 4B3MI 4ISAA 2PO1B 2NN6D 1I94E 5LMUI 4DR3I 3H1CA 1VISA 1KIJA 2PNZA 4I3HA 4GKJE 2OI2A 4FWHA 4YY3I 1Z0WA 4URLA 4DR4E 3HKMA 4IFDD 1Z59A 4WUBA 1OYPA 3V2UC 2VF3A 4J3DA 5A2QC 4JI6E 1PVGA 4USKA 1ZM3A 3ZKDA 4RPFA 4K0KI 1XMQE 4DU7A 1N0VC 1Z5BA 3ZZUA 5FLXC 1Z0CA 3B82A 2PNZB 5C0XA 4JV5I 4DV2I 4AM3A 3ZZ0A 4DV5E 4LF7I 4LF8E 5A2QQ 2E5LE 4LF6E 4GKKI 2IESA 2UUAE 2GO4A 1USVA 1B63A 5L3JA 4IZJA 2VQEI 4DV4I 1H7SA 4DPTA 3U1KA 4LFCE 2Z5CB 2R3VA 4MU1A 2ZM6E 1YHCA 2UUBI 3PYEA 5FLXQ 5DRRA 1J5EI 1K47A 4B3SE 3ZKBA 1IBLI 5K36E 1Z0VA 4DPYA 4YHHI 3M85G 4AQYE 5IT9C 1D6TA 5JEAA 4P7AA 4LF9E 4OX9I 1N33I 4OX9E 1HR0E 4FWGA 1HNXI 4JI2E 1USUA 4DR1E 2R42A 1R6MA 1E3PA 1UDQA 4JI5E 2A2DA 2O3ZA 5K36C 1E3HA 3P3EA 4DR6I 3ZZTA 4IZJB 2HFSA 2HK3A 3GONA 4DR5I 1XHKA 4JYAE 1H73A 5IT9Q 3UHMA 1Y60A 3Q1QA 4JI7I 2HK2A 2C38A 2Z5BA 5JEAB 4XTJA 1XNRI 3PS2A 1B62A 2HHHI 3U1YA 2UXBI 1ZXMA 3GMEA 4ED4A 2UXDE 4U3DA 4DUZE 2O1TA 4USMA 1IBMI 2O1UA 3V5RA 2A2CA 4OO1E 2Z5EA 2AE8A 2GO3A 2IOPA 4DPWA 4OKGA 2BA1D 3QT6A 1HNZE 3PS3A 3PYGA 1N36I 4DV1I 1ELOA 2C38B 1Z0GA 1I94I 2J7KA 2WP8B 4FW3A 3M6AA 1BKNA 5JEAD 4Z7CA 5DROA 2C39A 4OO1C 3P3CA 4GKJI 3P76A 1ZXNA 1Y5YA 2BA0D 4FW6A 2PNLA 4HYMA 4DR4I 1OYSA 4NXNE 4JI6I 3LPSA 1PKPA 3QT7A 2BR2B 2UUCE 3K17A 3HJCA 2PO0A 2Z5CA 4GQUA 4DUYE 1XMQI 2UXCE 4OO1F 1HNWE 4MDTA 4FWDA 4DXLA 2C39B 1KTVA 2CZ9A 1NHJA 3T1HE 1VI7A 3JAMC 4DV5I 1XNQE 2HKJA 3M7NG 3Q6NA 2Q2EB 3J7AM 3LTOA 4LF8I 2E5LI 1Z0EA 3T1YE 1S4EA 2XEXA 4LF6I 1Y4UA 2UUAI 4JI8E 4X64E 1ZM2A 5IWAE 2AJ4A 5ELWA 1PIEA 3DD6A 5C0XE 3P06A 2JEAA 4LFCI 2PO0B 2UU9E 3NZKA 2ZM6I 4B3SI 1MX0A 2F4VE 1OYRA 4QNKA 3B8HA 5GMEA 3JAMQ 4AQYI 1Z0BA 2CGEA 3WU3A 5C0XC 4B3TI 4N3OA 4LF9I 2X36A 4B3TE 2EFGA 4FW5A 1HR0I 4JI2I 4DR1I 5EL9A 3OTOI 4X65E 3OTOE 4LF5E 5BR8I 5BR8E 3QT8A 4JI5I 1UDNA 2NN6E 2VQFE 3GCMA 4WUCA 2JEAB 1XXEA 4IS9A 4JYAI 1HK7A 4X62E 2BA1G 1FJGE 1H72C 4MYTA 2NN6C 1MU5A 4FN5A 2ZBKB 4JI1I 2WP8A 4JI1E 4IFDE 1NZ0A 5K36B 4DV6E 1N32E 4BA1A 1RHYA 2C37A 4AIMA 1ZM4A 2V2QA 3B4TA 2UXDI 5K36F 4LOMA 2BA0G 5LMNI 5LMNE 4R1FA 4HACA 4DV7E 1Y6ZA 3PS1A 4DUZI 4MQYA 3KRNA 5DRQA 1UEKA 4IFDC 5LL6R 2ZITA 4LPFA 4LFAE 4Z7YA 3CDJA 4DU8A 4DR2E 2BR2A 2O1WA 1HNZI 4OO1A 1S16A 3PYDA 2V2VA 2WW4A 4OZEA 2X7IA 4BA1B 2C37B 4FW7A 4MYUA 5K36D 4UT4A 4DR7I 4DR7E 4LFBE 4JI0I 2BV3A 4JI0E 3HULA 3K1JA 1XMOE 1Z0TA 4HXZA 4PRVA 1N34E 4HACB 4IFDF 2DEIA 3Q6MA 4B3RI 1OJ4A 4B3RE 1KKHA 4WUDA 4JI4E 4NXNI
chains in the Genus database with same CATH topology
1YH8A 2IESA 4FW4A 2JT2A 4LCGA 4FW5A 2GO4A 3PS3A 4LCFA 3PS2A 4ISAA 3P3GA 3U1YA 4FW3A 1P42A 2O3ZA 4OZEA 2IERA 5DROA 4LCHA 4FW7A 3P3EA 3P3CA 3NZKA 3P76A 1YHCA 2VESA 4MDTA 4U3DA 3PS1A 5DRRA 4FW6A 1XXEA 4MQYA 4U3BA 5DRQA 4IS9A 2J65A 2GO3A 5DRPA 3UHMA 4J3DA 4OKGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YH8 A;  2IES A;  4FW4 A;  2JT2 A;  4LCG A;  4FW5 A;  2GO4 A;  3PS3 A;  4LCF A;  3PS2 A;  4ISA A;  3P3G A;  3U1Y A;  4FW3 A;  1P42 A;  2O3Z A;  4OZE A;  2IER A;  5DRO A;  4LCH A;  4FW7 A;  3P3E A;  3P3C A;  3NZK A;  3P76 A;  1YHC A;  2VES A;  4MDT A;  4U3D A;  3PS1 A;  5DRR A;  4FW6 A;  1XXE A;  4MQY A;  4U3B A;  5DRQ A;  4IS9 A;  2J65 A;  2GO3 A;  5DRP A;  3UHM A;  4J3D A;  4OKG A; 
#chains in the Genus database with same CATH topology
 4B3M E;  5FWK A;  5LMU E;  5EKW A;  2UUC I;  4DPU A;  4DR3 E;  2E1R A;  4OO1 B;  4DUY I;  2UXC I;  1DAR A;  1KVK A;  1FNM A;  4IZK A;  1HNW I;  1FWK A;  2F1D A;  2VES A;  1UDS A;  3PRY A;  1H7U A;  4YY3 E;  4U3B A;  3T1H I;  4DPX A;  1FWL A;  1R6L A;  1H74 A;  4FW9 A;  1XNQ I;  3J81 C;  3T1Y I;  4BA2 A;  3K85 A;  4LCF A;  4JI8 I;  4X64 I;  5IWA I;  3WU4 A;  4K0K E;  4MU3 A;  4DV3 I;  4DV3 E;  4NBQ A;  1NHH A;  4LF4 I;  3GLL A;  3F0N A;  4LF4 E;  2UU9 I;  4KHP I;  4KHP E;  4MU4 A;  4OO1 D;  4IZK B;  4UTG A;  4NXM I;  4NXM E;  4JV5 E;  4DV2 E;  3L7Z A;  2F4V I;  3QT5 A;  3WU6 A;  1A6F A;  2CVE A;  2DEJ A;  4LF7 E;  1Z5C A;  3J81 Q;  4QNJ A;  4GKK E;  5K36 A;  1RRE A;  2JT2 A;  2HFU A;  5DNL A;  4KQV A;  4X65 I;  2VQE E;  4DV4 E;  4BA2 B;  4LF5 I;  4PRX A;  3H4L A;  2IER A;  2GQ0 A;  1Z5A A;  2VQF I;  1N0U A;  1EA6 A;  2UUB E;  1J5E E;  5JEA E;  1IBL E;  2NN6 A;  2WNR A;  4X66 I;  2PNM A;  4X66 E;  2PO2 A;  4YHH E;  5C0X B;  2J65 A;  3CDI A;  4X62 I;  1FJG I;  4ZVI A;  1WUU A;  3L7Z B;  4JI3 I;  4JI3 E;  1N33 E;  3M7N D;  2CG9 A;  5C0X F;  4M1K A;  1HNX E;  3WU5 A;  4DV6 I;  1ZM9 A;  2JE6 A;  1N32 I;  5JEA C;  2LJP A;  3D4J A;  1P42 A;  1IBK I;  4IFD A;  1UDO A;  1IBK E;  4DR6 E;  2BM0 A;  4JG4 A;  1FI4 A;  4HY1 A;  2JEB A;  3CWV A;  4DV7 I;  1Y4S A;  4DR5 E;  1U2R A;  3J7A G;  5DNX A;  1RR9 A;  3J80 C;  2NN6 B;  2WNR B;  4LFA I;  5DRP A;  1QZR A;  2PO2 B;  3LNU A;  1NHI A;  4JI7 E;  3ZM7 A;  3M85 D;  2PO1 A;  4DV0 I;  2V8P A;  4DR2 I;  4DV0 E;  1MG7 A;  4FW4 A;  5GMD A;  4PU9 A;  2NN6 F;  4EMD A;  5C0X D;  1XNR E;  2O1V A;  2HHH E;  3P3G A;  2UXB E;  5JEA F;  2V2Z A;  2IOQ A;  2HKE A;  4MU0 A;  4LCH A;  2JE6 B;  1FKA E;  4IFD B;  1IBM E;  4LFB I;  1XMO I;  2JEB B;  3B78 A;  1N34 I;  1EI1 A;  4IZJ D;  2NPF A;  3J80 Q;  2V34 A;  2GS8 A;  4JI4 I;  4AID A;  1YH8 A;  2BM1 A;  3PYF A;  4LCG A;  4P52 A;  1N36 E;  2Z5B B;  4DV1 E;  4B3M I;  4ISA A;  2PO1 B;  2NN6 D;  1I94 E;  5LMU I;  4DR3 I;  3H1C A;  1VIS A;  1KIJ A;  2PNZ A;  4I3H A;  4GKJ E;  2OI2 A;  4FWH A;  4YY3 I;  1Z0W A;  4URL A;  4DR4 E;  3HKM A;  4IFD D;  1Z59 A;  4WUB A;  1OYP A;  3V2U C;  2VF3 A;  4J3D A;  5A2Q C;  4JI6 E;  1PVG A;  4USK A;  1ZM3 A;  3ZKD A;  4RPF A;  4K0K I;  1XMQ E;  4DU7 A;  1N0V C;  1Z5B A;  3ZZU A;  5FLX C;  1Z0C A;  3B82 A;  2PNZ B;  5C0X A;  4JV5 I;  4DV2 I;  4AM3 A;  3ZZ0 A;  4DV5 E;  4LF7 I;  4LF8 E;  5A2Q Q;  2E5L E;  4LF6 E;  4GKK I;  2IES A;  2UUA E;  2GO4 A;  1USV A;  1B63 A;  5L3J A;  4IZJ A;  2VQE I;  4DV4 I;  1H7S A;  4DPT A;  3U1K A;  4LFC E;  2Z5C B;  2R3V A;  4MU1 A;  2ZM6 E;  1YHC A;  2UUB I;  3PYE A;  5FLX Q;  5DRR A;  1J5E I;  1K47 A;  4B3S E;  3ZKB A;  1IBL I;  5K36 E;  1Z0V A;  4DPY A;  4YHH I;  3M85 G;  4AQY E;  5IT9 C;  1D6T A;  5JEA A;  4P7A A;  4LF9 E;  4OX9 I;  1N33 I;  4OX9 E;  1HR0 E;  4FWG A;  1HNX I;  4JI2 E;  1USU A;  4DR1 E;  2R42 A;  1R6M A;  1E3P A;  1UDQ A;  4JI5 E;  2A2D A;  2O3Z A;  5K36 C;  1E3H A;  3P3E A;  4DR6 I;  3ZZT A;  4IZJ B;  2HFS A;  2HK3 A;  3GON A;  4DR5 I;  1XHK A;  4JYA E;  1H73 A;  5IT9 Q;  3UHM A;  1Y60 A;  3Q1Q A;  4JI7 I;  2HK2 A;  2C38 A;  2Z5B A;  5JEA B;  4XTJ A;  1XNR I;  3PS2 A;  1B62 A;  2HHH I;  3U1Y A;  2UXB I;  1ZXM A;  3GME A;  4ED4 A;  2UXD E;  4U3D A;  4DUZ E;  2O1T A;  4USM A;  1IBM I;  2O1U A;  3V5R A;  2A2C A;  4OO1 E;  2Z5E A;  2AE8 A;  2GO3 A;  2IOP A;  4DPW A;  4OKG A;  2BA1 D;  3QT6 A;  1HNZ E;  3PS3 A;  3PYG A;  1N36 I;  4DV1 I;  1ELO A;  2C38 B;  1Z0G A;  1I94 I;  2J7K A;  2WP8 B;  4FW3 A;  3M6A A;  1BKN A;  5JEA D;  4Z7C A;  5DRO A;  2C39 A;  4OO1 C;  3P3C A;  4GKJ I;  3P76 A;  1ZXN A;  1Y5Y A;  2BA0 D;  4FW6 A;  2PNL A;  4HYM A;  4DR4 I;  1OYS A;  4NXN E;  4JI6 I;  3LPS A;  1PKP A;  3QT7 A;  2BR2 B;  2UUC E;  3K17 A;  3HJC A;  2PO0 A;  2Z5C A;  4GQU A;  4DUY E;  1XMQ I;  2UXC E;  4OO1 F;  1HNW E;  4MDT A;  4FWD A;  4DXL A;  2C39 B;  1KTV A;  2CZ9 A;  1NHJ A;  3T1H E;  1VI7 A;  3JAM C;  4DV5 I;  1XNQ E;  2HKJ A;  3M7N G;  3Q6N A;  2Q2E B;  3J7A M;  3LTO A;  4LF8 I;  2E5L I;  1Z0E A;  3T1Y E;  1S4E A;  2XEX A;  4LF6 I;  1Y4U A;  2UUA I;  4JI8 E;  4X64 E;  1ZM2 A;  5IWA E;  2AJ4 A;  5ELW A;  1PIE A;  3DD6 A;  5C0X E;  3P06 A;  2JEA A;  4LFC I;  2PO0 B;  2UU9 E;  3NZK A;  2ZM6 I;  4B3S I;  1MX0 A;  2F4V E;  1OYR A;  4QNK A;  3B8H A;  5GME A;  3JAM Q;  4AQY I;  1Z0B A;  2CGE A;  3WU3 A;  5C0X C;  4B3T I;  4N3O A;  4LF9 I;  2X36 A;  4B3T E;  2EFG A;  4FW5 A;  1HR0 I;  4JI2 I;  4DR1 I;  5EL9 A;  3OTO I;  4X65 E;  3OTO E;  4LF5 E;  5BR8 I;  5BR8 E;  3QT8 A;  4JI5 I;  1UDN A;  2NN6 E;  2VQF E;  3GCM A;  4WUC A;  2JEA B;  1XXE A;  4IS9 A;  4JYA I;  1HK7 A;  4X62 E;  2BA1 G;  1FJG E;  1H72 C;  4MYT A;  2NN6 C;  1MU5 A;  4FN5 A;  2ZBK B;  4JI1 I;  2WP8 A;  4JI1 E;  4IFD E;  1NZ0 A;  5K36 B;  4DV6 E;  1N32 E;  4BA1 A;  1RHY A;  2C37 A;  4AIM A;  1ZM4 A;  2V2Q A;  3B4T A;  2UXD I;  5K36 F;  4LOM A;  2BA0 G;  5LMN I;  5LMN E;  4R1F A;  4HAC A;  4DV7 E;  1Y6Z A;  3PS1 A;  4DUZ I;  4MQY A;  3KRN A;  5DRQ A;  1UEK A;  4IFD C;  5LL6 R;  2ZIT A;  4LPF A;  4LFA E;  4Z7Y A;  3CDJ A;  4DU8 A;  4DR2 E;  2BR2 A;  2O1W A;  1HNZ I;  4OO1 A;  1S16 A;  3PYD A;  2V2V A;  2WW4 A;  4OZE A;  2X7I A;  4BA1 B;  2C37 B;  4FW7 A;  4MYU A;  5K36 D;  4UT4 A;  4DR7 I;  4DR7 E;  4LFB E;  4JI0 I;  2BV3 A;  4JI0 E;  3HUL A;  3K1J A;  1XMO E;  1Z0T A;  4HXZ A;  4PRV A;  1N34 E;  4HAC B;  4IFD F;  2DEI A;  3Q6M A;  4B3R I;  1OJ4 A;  4B3R E;  1KKH A;  4WUD A;  4JI4 E;  4NXN I; 
#chains in the Genus database with same CATH homology
 1YH8 A;  2IES A;  4FW4 A;  2JT2 A;  4LCG A;  4FW5 A;  2GO4 A;  3PS3 A;  4LCF A;  3PS2 A;  4ISA A;  3P3G A;  3U1Y A;  4FW3 A;  1P42 A;  2O3Z A;  4OZE A;  2IER A;  5DRO A;  4LCH A;  4FW7 A;  3P3E A;  3P3C A;  3NZK A;  3P76 A;  1YHC A;  2VES A;  4MDT A;  4U3D A;  3PS1 A;  5DRR A;  4FW6 A;  1XXE A;  4MQY A;  4U3B A;  5DRQ A;  4IS9 A;  2J65 A;  2GO3 A;  5DRP A;  3UHM A;  4J3D A;  4OKG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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