4FW4A

Crystal structure of the lpxc in complex with n-[(1s,2r)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide inhibitor
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
300
structure length
300
Chain Sequence
AMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the LpxC
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Pseudomonas aeruginosa
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 89
structure length 300
sequence length 300
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw4A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw4A02
2O3ZA 4ISAA 3NZKA 4FW6A 4MDTA 4IS9A 4FW7A 4OKGA 1P42A 4U3DA 3PS3A 3P3EA 2GO3A 1XXEA 3UHMA 4OZEA 5DRPA 3U1YA 4LCGA 1YHCA 4FW4A 2IESA 4U3BA 4MQYA 1YH8A 4LCFA 3P76A 3PS1A 2JT2A 2J65A 4FW3A 3P3GA 3PS2A 5DRQA 2GO4A 4J3DA 5DRRA 2IERA 2VESA 5DROA 4LCHA 4FW5A 3P3CA
chains in the Genus database with same CATH superfamily
4OO1D 4FW9A 3NZKA 4ISAA 3KRNA 4IZJB 4DXLA 3HULA 4MU3A 1VI7A 2V2VA 4BA1B 4B3SI 5FLXC 4NXMI 2BA0D 3K1JA 1PKPA 3J81C 1N36E 2Z5BA 3T1HE 4U3BA 2JEBA 4Z7CA 4OX9I 3DD6A 4DV6I 5EKWA 2PO1B 2UU9E 2HKEA 2PO0B 4DV3E 1Y4SA 5JEAA 3Q1QA 2EFGA 4DR3E 2Z5CB 2C39A 1HNZE 1H73A 2PNLA 1RREA 2VQFI 4GKKI 5K36B 2WNRB 4JI7I 5C0XF 1ELOA 2NN6B 3M85D 4BA1A 1ZXMA 1H72C 4DR6I 4LCGA 3J81Q 1N0VC 1I94E 2UUCE 1XNQI 3T1YI 2V2QA 2PO1A 2HHHE 2PO0A 2VESA 2ZBKB 3HKMA 4MDTA 1ZM9A 4LF4I 4IFDB 1XNRE 1Z5AA 2ZITA 2DEJA 4DPTA 5K36A 4AM3A 4X66I 4DV0I 5C0XD 3UHMA 4B3RE 1HNWE 1Z0VA 2CG9A 2NN6A 4KQVA 4X62I 4JI8E 3QT8A 4DR2I 4M1KA 5JEAF 2AJ4A 1IBKE 2R3VA 1FKAE 4MYTA 5LMUI 1KIJA 1S4EA 3ZKDA 4PU9A 2C37B 1EI1A 4DR5E 5BR8I 4IFDA 4MU1A 2WP8B 2CZ9A 4B3TE 1Z59A 4DR4I 1J5EI 2UXBI 4JI5E 3OTOI 5GMDA 3PYDA 4DV1I 2IOQA 2IERA 4AQYI 2PNZB 2UUBI 4DR1I 5IWAI 4JI6E 2J7KA 4XTJA 3JAMC 4OKGA 5K36F 3PRYA 2C37A 1Z0GA 1NHHA 2NN6F 2V8PA 4HACB 2OI2A 2WP8A 3QT6A 3P06A 4DPUA 4AIMA 1N33I 2IESA 4YHHI 3CDJA 5A2QQ 4YY3E 4OO1E 5FWKA 4DV7I 1XMOE 1Z0BA 2O1UA 3P3GA 2A2DA 4MU4A 4DV4E 5K36E 4KHPI 1ZXNA 2NN6E 4I3HA 1IBME 4IFDF 2F4VE 4P7AA 3GMEA 2AE8A 1N36I 5K36D 4LOMA 3JAMQ 3PYFA 4USMA 3T1HI 4HACA 4JI3E 2NN6D 4JI2E 2E1RA 2UU9I 1HR0E 2ZM6I 4DV3I 1NHIA 4UTGA 1WUUA 2GS8A 1N34E 1Z5CA 2WW4A 2UXCE 4GQUA 2BA0G 1HNZI 3WU6A 3WU4A 3J7AM 4IFDE 1H74A 1IBLE 2O1WA 4P52A 5LMNE 1DARA 4NXNE 4FW7A 4IZJA 4U3DA 4DPWA 3V5RA 4DV2E 2JEAB 3PS3A 4IFDD 1N32E 4GKJE 1KVKA 4BA2B 4NBQA 2UUCI 4MQYA 4QNKA 4JI1E 1MX0A 1U2RA 3M85G 1Z0EA 5DRQA 2IOPA 2UXDI 2BA1D 1XHKA 4LCHA 5DROA 1XNRI 5C0XE 4LFCE 2Z5CA 4Z7YA 4LPFA 1UDOA 3J7AG 2VF3A 1QZRA 3ZKBA 4B3RI 1HNWI 4DUZE 4PRVA 4LF9E 4DV5E 1Z0TA 4JV5I 1N0UA 2JEAA 2WNRA 1ZM3A 4JI8I 4JYAE 3U1YA 4OO1C 4X65E 1YH8A 4LF8E 1BKNA 1FJGI 5LL6R 2JT2A 1IBKI 3PS2A 1UEKA 5L3JA 3Q6NA 2UUAE 4J3DA 1XNQE 2GQ0A 2NN6C 1MU5A 2C38B 5GMEA 4DR5I 3ZZ0A 3CDIA 3LPSA 4RPFA 4IS9A 4LFBE 1P42A 4B3TI 1Z5BA 1MG7A 3M7ND 1FWKA 2JE6B 1HNXE 2GO3A 4DUYE 2V2ZA 1PVGA 4OZEA 3ZZUA 5A2QC 1K47A 5JEAE 4ZVIA 4X64E 4LF6I 2X36A 4JI0I 1A6FA 2BM0A 3ZZTA 4IFDC 3PS1A 4LF5E 1KKHA 2CGEA 2CVEA 4URLA 4B3ME 4MU0A 1S16A 4JI6I 1XMQE 1PIEA 5JEAD 4FW5A 3V2UC 2VQEE 2HKJA 1UDSA 3H4LA 2C38A 1EA6A 4DR7E 4IZJD 4JI4E 2Z5EA 4QNJA 5BR8E 4N3OA 2NPFA 3K17A 4YY3I 2E5LE 2HK2A 2UXBE 1XMOI 2BR2B 1RHYA 3OTOE 1HK7A 1VISA 1H7SA 5C0XC 4WUBA 1IBMI 2F4VI 2O3ZA 1E3HA 1USVA 4FW6A 4FWGA 2PNZA 5ELWA 5IWAE 4IZKB 3U1KA 4R1FA 1FWLA 1R6MA 4LF7E 4JI2I 3Q6MA 2Z5BB 1Y6ZA 4EMDA 1HR0I 4DPXA 2JEBB 4HXZA 4LFAE 1Z0WA 1N34I 2DEIA 4YHHE 3L7ZB 2F1DA 4DR3I 4DV7E 5LMNI 3HJCA 4NXNI 4DV2I 4DU7A 4K0KE 4KHPE 3B4TA 4DPYA 1ZM4A 1N32I 3LTOA 4GKJI 3B82A 1XXEA 4IZKA 5JEAC 4B3SE 2PO2B 4NXME 1ZM2A 4JI1I 1I94I 3K85A 4MYUA 4LCFA 2ZM6E 2HHHI 5DNLA 3L7ZA 3B8HA 4OX9E 4DV6E 1R6LA 4LFCI 1H7UA 4OO1B 3PYEA 4DUZI 4LF9I 4DV5I 2VQFE 4GKKE 1Z0CA 3P3EA 3WU3A 2BA1G 4JYAI 1Y4UA 2O1VA 4JI7E 1RR9A 3CWVA 4X65I 5FLXQ 3GONA 4LF8I 2PO2A 4UT4A 3H1CA 4BA2A 2UUAI 4DR6E 1Y5YA 1B63A 1OYSA 4FW3A 3WU5A 3B78A 5K36C 4DU8A 3T1YE 3F0NA 4OO1A 2UXDE 3P3CA 4LFBI 2HK3A 1HNXI 4DUYI 2X7IA 4LF4E 4HY1A 4FWDA 4JI5I 4PRXA 4X64I 4JV5E 4X66E 4DV0E 4ED4A 4FW4A 4AIDA 4LF5I 4X62E 3M7NG 4B3MI 3P76A 4FN5A 4FWHA 1XMQI 2HFUA 2VQEI 3D4JA 1FJGE 4DR2E 4JG4A 2HFSA 3J80C 1D6TA 4DR7I 5DRRA 3M6AA 4JI4I 4HYMA 5C0XB 1Y60A 2V34A 5LMUE 2A2CA 2E5LI 1FI4A 2Q2EB 2JE6A 1OJ4A 5DRPA 5IT9C 4DR4E 2BM1A 3LNUA 3ZM7A 1UDNA 5DNXA 1J5EE 3PYGA 1B62A 2XEXA 5EL9A 4LF6E 4JI0E 4DV4I 2GO4A 4USKA 4OO1F 4DV1E 1E3PA 1UDQA 3QT5A 3GLLA 4AQYE 3J80Q 2UUBE 1OYPA 4LF7I 4DR1E 2PNMA 2R42A 5C0XA 2LJPA 4LFAI 4JI3I 3QT7A 4WUDA 2O1TA 1YHCA 1OYRA 1NHJA 2UXCI 1N33E 1USUA 4WUCA 2BV3A 5IT9Q 5JEAB 2J65A 1IBLI 2BR2A 1FNMA 2C39B 3GCMA 1NZ0A 4K0KI 1KTVA
chains in the Genus database with same CATH topology
2O3ZA 4ISAA 3NZKA 4FW6A 4MDTA 4IS9A 4FW7A 4OKGA 1P42A 4U3DA 3PS3A 3P3EA 2GO3A 1XXEA 3UHMA 4OZEA 5DRPA 3U1YA 4LCGA 1YHCA 4FW4A 2IESA 4U3BA 4MQYA 1YH8A 4LCFA 3P76A 3PS1A 2JT2A 2J65A 4FW3A 3P3GA 3PS2A 5DRQA 2GO4A 4J3DA 5DRRA 2IERA 2VESA 5DROA 4LCHA 4FW5A 3P3CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O3Z A;  4ISA A;  3NZK A;  4FW6 A;  4MDT A;  4IS9 A;  4FW7 A;  4OKG A;  1P42 A;  4U3D A;  3PS3 A;  3P3E A;  2GO3 A;  1XXE A;  3UHM A;  4OZE A;  5DRP A;  3U1Y A;  4LCG A;  1YHC A;  4FW4 A;  2IES A;  4U3B A;  4MQY A;  1YH8 A;  4LCF A;  3P76 A;  3PS1 A;  2JT2 A;  2J65 A;  4FW3 A;  3P3G A;  3PS2 A;  5DRQ A;  2GO4 A;  4J3D A;  5DRR A;  2IER A;  2VES A;  5DRO A;  4LCH A;  4FW5 A;  3P3C A; 
#chains in the Genus database with same CATH topology
 4OO1 D;  4FW9 A;  3NZK A;  4ISA A;  3KRN A;  4IZJ B;  4DXL A;  3HUL A;  4MU3 A;  1VI7 A;  2V2V A;  4BA1 B;  4B3S I;  5FLX C;  4NXM I;  2BA0 D;  3K1J A;  1PKP A;  3J81 C;  1N36 E;  2Z5B A;  3T1H E;  4U3B A;  2JEB A;  4Z7C A;  4OX9 I;  3DD6 A;  4DV6 I;  5EKW A;  2PO1 B;  2UU9 E;  2HKE A;  2PO0 B;  4DV3 E;  1Y4S A;  5JEA A;  3Q1Q A;  2EFG A;  4DR3 E;  2Z5C B;  2C39 A;  1HNZ E;  1H73 A;  2PNL A;  1RRE A;  2VQF I;  4GKK I;  5K36 B;  2WNR B;  4JI7 I;  5C0X F;  1ELO A;  2NN6 B;  3M85 D;  4BA1 A;  1ZXM A;  1H72 C;  4DR6 I;  4LCG A;  3J81 Q;  1N0V C;  1I94 E;  2UUC E;  1XNQ I;  3T1Y I;  2V2Q A;  2PO1 A;  2HHH E;  2PO0 A;  2VES A;  2ZBK B;  3HKM A;  4MDT A;  1ZM9 A;  4LF4 I;  4IFD B;  1XNR E;  1Z5A A;  2ZIT A;  2DEJ A;  4DPT A;  5K36 A;  4AM3 A;  4X66 I;  4DV0 I;  5C0X D;  3UHM A;  4B3R E;  1HNW E;  1Z0V A;  2CG9 A;  2NN6 A;  4KQV A;  4X62 I;  4JI8 E;  3QT8 A;  4DR2 I;  4M1K A;  5JEA F;  2AJ4 A;  1IBK E;  2R3V A;  1FKA E;  4MYT A;  5LMU I;  1KIJ A;  1S4E A;  3ZKD A;  4PU9 A;  2C37 B;  1EI1 A;  4DR5 E;  5BR8 I;  4IFD A;  4MU1 A;  2WP8 B;  2CZ9 A;  4B3T E;  1Z59 A;  4DR4 I;  1J5E I;  2UXB I;  4JI5 E;  3OTO I;  5GMD A;  3PYD A;  4DV1 I;  2IOQ A;  2IER A;  4AQY I;  2PNZ B;  2UUB I;  4DR1 I;  5IWA I;  4JI6 E;  2J7K A;  4XTJ A;  3JAM C;  4OKG A;  5K36 F;  3PRY A;  2C37 A;  1Z0G A;  1NHH A;  2NN6 F;  2V8P A;  4HAC B;  2OI2 A;  2WP8 A;  3QT6 A;  3P06 A;  4DPU A;  4AIM A;  1N33 I;  2IES A;  4YHH I;  3CDJ A;  5A2Q Q;  4YY3 E;  4OO1 E;  5FWK A;  4DV7 I;  1XMO E;  1Z0B A;  2O1U A;  3P3G A;  2A2D A;  4MU4 A;  4DV4 E;  5K36 E;  4KHP I;  1ZXN A;  2NN6 E;  4I3H A;  1IBM E;  4IFD F;  2F4V E;  4P7A A;  3GME A;  2AE8 A;  1N36 I;  5K36 D;  4LOM A;  3JAM Q;  3PYF A;  4USM A;  3T1H I;  4HAC A;  4JI3 E;  2NN6 D;  4JI2 E;  2E1R A;  2UU9 I;  1HR0 E;  2ZM6 I;  4DV3 I;  1NHI A;  4UTG A;  1WUU A;  2GS8 A;  1N34 E;  1Z5C A;  2WW4 A;  2UXC E;  4GQU A;  2BA0 G;  1HNZ I;  3WU6 A;  3WU4 A;  3J7A M;  4IFD E;  1H74 A;  1IBL E;  2O1W A;  4P52 A;  5LMN E;  1DAR A;  4NXN E;  4FW7 A;  4IZJ A;  4U3D A;  4DPW A;  3V5R A;  4DV2 E;  2JEA B;  3PS3 A;  4IFD D;  1N32 E;  4GKJ E;  1KVK A;  4BA2 B;  4NBQ A;  2UUC I;  4MQY A;  4QNK A;  4JI1 E;  1MX0 A;  1U2R A;  3M85 G;  1Z0E A;  5DRQ A;  2IOP A;  2UXD I;  2BA1 D;  1XHK A;  4LCH A;  5DRO A;  1XNR I;  5C0X E;  4LFC E;  2Z5C A;  4Z7Y A;  4LPF A;  1UDO A;  3J7A G;  2VF3 A;  1QZR A;  3ZKB A;  4B3R I;  1HNW I;  4DUZ E;  4PRV A;  4LF9 E;  4DV5 E;  1Z0T A;  4JV5 I;  1N0U A;  2JEA A;  2WNR A;  1ZM3 A;  4JI8 I;  4JYA E;  3U1Y A;  4OO1 C;  4X65 E;  1YH8 A;  4LF8 E;  1BKN A;  1FJG I;  5LL6 R;  2JT2 A;  1IBK I;  3PS2 A;  1UEK A;  5L3J A;  3Q6N A;  2UUA E;  4J3D A;  1XNQ E;  2GQ0 A;  2NN6 C;  1MU5 A;  2C38 B;  5GME A;  4DR5 I;  3ZZ0 A;  3CDI A;  3LPS A;  4RPF A;  4IS9 A;  4LFB E;  1P42 A;  4B3T I;  1Z5B A;  1MG7 A;  3M7N D;  1FWK A;  2JE6 B;  1HNX E;  2GO3 A;  4DUY E;  2V2Z A;  1PVG A;  4OZE A;  3ZZU A;  5A2Q C;  1K47 A;  5JEA E;  4ZVI A;  4X64 E;  4LF6 I;  2X36 A;  4JI0 I;  1A6F A;  2BM0 A;  3ZZT A;  4IFD C;  3PS1 A;  4LF5 E;  1KKH A;  2CGE A;  2CVE A;  4URL A;  4B3M E;  4MU0 A;  1S16 A;  4JI6 I;  1XMQ E;  1PIE A;  5JEA D;  4FW5 A;  3V2U C;  2VQE E;  2HKJ A;  1UDS A;  3H4L A;  2C38 A;  1EA6 A;  4DR7 E;  4IZJ D;  4JI4 E;  2Z5E A;  4QNJ A;  5BR8 E;  4N3O A;  2NPF A;  3K17 A;  4YY3 I;  2E5L E;  2HK2 A;  2UXB E;  1XMO I;  2BR2 B;  1RHY A;  3OTO E;  1HK7 A;  1VIS A;  1H7S A;  5C0X C;  4WUB A;  1IBM I;  2F4V I;  2O3Z A;  1E3H A;  1USV A;  4FW6 A;  4FWG A;  2PNZ A;  5ELW A;  5IWA E;  4IZK B;  3U1K A;  4R1F A;  1FWL A;  1R6M A;  4LF7 E;  4JI2 I;  3Q6M A;  2Z5B B;  1Y6Z A;  4EMD A;  1HR0 I;  4DPX A;  2JEB B;  4HXZ A;  4LFA E;  1Z0W A;  1N34 I;  2DEI A;  4YHH E;  3L7Z B;  2F1D A;  4DR3 I;  4DV7 E;  5LMN I;  3HJC A;  4NXN I;  4DV2 I;  4DU7 A;  4K0K E;  4KHP E;  3B4T A;  4DPY A;  1ZM4 A;  1N32 I;  3LTO A;  4GKJ I;  3B82 A;  1XXE A;  4IZK A;  5JEA C;  4B3S E;  2PO2 B;  4NXM E;  1ZM2 A;  4JI1 I;  1I94 I;  3K85 A;  4MYU A;  4LCF A;  2ZM6 E;  2HHH I;  5DNL A;  3L7Z A;  3B8H A;  4OX9 E;  4DV6 E;  1R6L A;  4LFC I;  1H7U A;  4OO1 B;  3PYE A;  4DUZ I;  4LF9 I;  4DV5 I;  2VQF E;  4GKK E;  1Z0C A;  3P3E A;  3WU3 A;  2BA1 G;  4JYA I;  1Y4U A;  2O1V A;  4JI7 E;  1RR9 A;  3CWV A;  4X65 I;  5FLX Q;  3GON A;  4LF8 I;  2PO2 A;  4UT4 A;  3H1C A;  4BA2 A;  2UUA I;  4DR6 E;  1Y5Y A;  1B63 A;  1OYS A;  4FW3 A;  3WU5 A;  3B78 A;  5K36 C;  4DU8 A;  3T1Y E;  3F0N A;  4OO1 A;  2UXD E;  3P3C A;  4LFB I;  2HK3 A;  1HNX I;  4DUY I;  2X7I A;  4LF4 E;  4HY1 A;  4FWD A;  4JI5 I;  4PRX A;  4X64 I;  4JV5 E;  4X66 E;  4DV0 E;  4ED4 A;  4FW4 A;  4AID A;  4LF5 I;  4X62 E;  3M7N G;  4B3M I;  3P76 A;  4FN5 A;  4FWH A;  1XMQ I;  2HFU A;  2VQE I;  3D4J A;  1FJG E;  4DR2 E;  4JG4 A;  2HFS A;  3J80 C;  1D6T A;  4DR7 I;  5DRR A;  3M6A A;  4JI4 I;  4HYM A;  5C0X B;  1Y60 A;  2V34 A;  5LMU E;  2A2C A;  2E5L I;  1FI4 A;  2Q2E B;  2JE6 A;  1OJ4 A;  5DRP A;  5IT9 C;  4DR4 E;  2BM1 A;  3LNU A;  3ZM7 A;  1UDN A;  5DNX A;  1J5E E;  3PYG A;  1B62 A;  2XEX A;  5EL9 A;  4LF6 E;  4JI0 E;  4DV4 I;  2GO4 A;  4USK A;  4OO1 F;  4DV1 E;  1E3P A;  1UDQ A;  3QT5 A;  3GLL A;  4AQY E;  3J80 Q;  2UUB E;  1OYP A;  4LF7 I;  4DR1 E;  2PNM A;  2R42 A;  5C0X A;  2LJP A;  4LFA I;  4JI3 I;  3QT7 A;  4WUD A;  2O1T A;  1YHC A;  1OYR A;  1NHJ A;  2UXC I;  1N33 E;  1USU A;  4WUC A;  2BV3 A;  5IT9 Q;  5JEA B;  2J65 A;  1IBL I;  2BR2 A;  1FNM A;  2C39 B;  3GCM A;  1NZ0 A;  4K0K I;  1KTV A; 
#chains in the Genus database with same CATH homology
 2O3Z A;  4ISA A;  3NZK A;  4FW6 A;  4MDT A;  4IS9 A;  4FW7 A;  4OKG A;  1P42 A;  4U3D A;  3PS3 A;  3P3E A;  2GO3 A;  1XXE A;  3UHM A;  4OZE A;  5DRP A;  3U1Y A;  4LCG A;  1YHC A;  4FW4 A;  2IES A;  4U3B A;  4MQY A;  1YH8 A;  4LCF A;  3P76 A;  3PS1 A;  2JT2 A;  2J65 A;  4FW3 A;  3P3G A;  3PS2 A;  5DRQ A;  2GO4 A;  4J3D A;  5DRR A;  2IER A;  2VES A;  5DRO A;  4LCH A;  4FW5 A;  3P3C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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