4LPFA

Crystal structure of mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
190
structure length
190
Chain Sequence
SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of the native, substrate- bound and inhibited forms of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase
rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis h37rv
molecule keywords Imidazoleglycerol-phosphate dehydratase
total genus 60
structure length 190
sequence length 190
ec nomenclature ec 4.2.1.19: Imidazoleglycerol-phosphate dehydratase.
pdb deposition date 2013-07-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.40 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 Imidazole glycerol phosphate dehydratase; domain 1 4lpfA01
3.30.230.40 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 Imidazole glycerol phosphate dehydratase; domain 1 4lpfA02
2F1DA 5DNXA 4QNKA 4GQUA 4MU1A 4LPFA 4MU3A 4QNJA 1RHYA 5EKWA 5DNLA 5ELWA 5EL9A 2AE8A 4MU0A 4MU4A 4LOMA
chains in the Genus database with same CATH superfamily
1XXEA 1RREA 3QT8A 1UDQA 4KHPE 4ED4A 3ZKDA 1P42A 1UEKA 4KHPI 3U1YA 1OJ4A 2VESA 3B82A 1KIJA 4OO1E 2AJ4A 1PKPA 2C39A 1N32E 1R6MA 1NHJA 2NN6B 4NBQA 2Q2EB 3CDIA 3HKMA 3J80C 4JI0I 3P3GA 4R1FA 2BA0G 3U1KA 3J80Q 2BA1D 4MU4A 1RR9A 2HHHE 4BA1A 4KQVA 5EL9A 2HHHI 5C0XB 4LFBE 5DROA 1ZXMA 3PS1A 3H1CA 4LFBI 2NN6E 2BR2A 1YH8A 4USMA 2CGEA 3P76A 5FWKA 2V2QA 1MX0A 4HXZA 5FLXC 5ELWA 2PO1A 4LF6E 2GO3A 3CDJA 4PU9A 1EI1A 4LF9I 1D6TA 4HY1A 4DV1E 5C0XE 2ZITA 1NHHA 1USVA 2BV3A 1KKHA 1XNQE 2CVEA 2NN6C 4QNJA 3PYFA 3OTOI 2UXBE 4IZJB 1Z0EA 2PO2B 3WU6A 4OO1D 4DXLA 2UUAE 3K1JA 4USKA 2X36A 4GKKE 2JE6A 4YY3E 2UUAI 5JEAB 4DR6E 4GKKI 2PNLA 4YY3I 5C0XC 4JI5E 4URLA 2XEXA 4B3SE 4DR6I 1N0VC 1E3HA 4B3SI 2NN6F 2X7IA 4PRXA 3Q6NA 3ZZ0A 4FN5A 1H72C 5A2QC 2BA1G 2WW4A 4FW6A 5K36F 4GQUA 2CG9A 2V2ZA 2R3VA 4ZVIA 1S4EA 4MYTA 2LJPA 2HK3A 4JYAE 4LF5E 2PNZA 4MQYA 5C0XF 5LMNE 4JYAI 2OI2A 4MYUA 4I3HA 1Z0WA 2BM0A 4DV7E 3L7ZA 4DPTA 5LMNI 2NN6A 4DV7I 3V2UC 2Z5BA 1WUUA 3CWVA 4LCHA 5GMEA 4DPYA 2HFSA 4ISAA 2VQFE 2J65A 1FWLA 2VQFI 4DU7A 2F1DA 1QZRA 1H73A 4JI4I 1Z0BA 5JEAC 5IWAI 4DPWA 5C0XA 2A2CA 4JI0E 4FW5A 1EA6A 4XTJA 4DPXA 4FW4A 4EMDA 4IFDB 4N3OA 5K36B 4MU0A 5DRQA 4AIDA 3QT7A 1ZM4A 2DEJA 3PYGA 2AE8A 5IT9C 2JEBB 1Z5CA 1FKAE 5JEAF 2C37B 2WP8B 4FWHA 1Z5AA 1IBKE 1OYPA 3NZKA 1IBKI 1J5EE 1U2RA 4JG4A 3LNUA 2V2VA 2DEIA 1J5EI 3WU5A 5K36E 4B3RE 4IZJA 1IBLE 4JI7E 3M85D 4LF9E 2PO2A 5FLXQ 1ELOA 4B3RI 1MU5A 1VI7A 4DR1E 1IBLI 4JI7I 4FW3A 3M7NG 1FWKA 3ZM7A 4DR3E 4HACA 4DR1I 1NHIA 4BA2A 4Z7CA 3PS2A 4DR3I 5JEAA 4LOMA 4M1KA 1RHYA 1HNWE 3OTOE 3WU3A 3JAMC 4LFAE 3ZZTA 1HNWI 1YHCA 4BA1B 1ZM2A 4LFAI 4IFDC 4DV0E 4NXNI 5K36C 4PRVA 4DUZE 4AQYE 5BR8E 2Z5CB 1B63A 4DPUA 4DV0I 4DUZI 4AQYI 2BM1A 5BR8I 2JEAB 4DR4E 2BR2B 1Z0CA 4LCFA 4DR4I 1Z0TA 1PVGA 4DV4E 4JI6E 5LL6R 3QT5A 2O1UA 4HYMA 4LPFA 3K85A 4DV4I 1HNXE 4JI6I 1Z0GA 2EFGA 3GCMA 2BA0D 1HNXI 4FWGA 1ZM3A 1E3PA 4IFDF 4OZEA 4QNKA 3B4TA 4P52A 5A2QQ 3WU4A 2HK2A 4X65E 4DUYE 4DV2E 2NN6D 4LCGA 4X65I 4Z7YA 4DUYI 4DR5E 1S16A 5JEAE 2O3ZA 4DV2I 3T1YE 4DR5I 3T1HI 2HFUA 3T1YI 3D4JA 4WUCA 1HK7A 3H4LA 2O1WA 3PS3A 4FW7A 3DD6A 4FWDA 3J81C 2C38B 1OYSA 1Y6ZA 3J7AM 1R6LA 4JI8E 5K36A 3M85G 5C0XD 4LF7E 4OO1B 4JI8I 1DARA 4JI4E 3HJCA 1Z59A 4IS9A 3M6AA 4UTGA 3F0NA 2CZ9A 1ZXNA 3UHMA 3KRNA 5IWAE 4LF7I 2PO0B 2JEBA 4DR7E 4P7AA 3P06A 4X62E 2UUBE 2F4VE 1FI4A 4DR7I 3QT6A 3GMEA 4B3MI 3PYDA 4X62I 2UUBI 4JI2E 2F4VI 3B8HA 2WP8A 4JI2I 1Y60A 1N0UA 1USUA 1UDNA 4IZKB 1XNRE 3Q1QA 2WNRB 1Z0VA 2HKJA 4DV5E 1XNRI 2PNZB 1Y4UA 2IOQA 1XMOE 2E5LE 4DV5I 4WUBA 1XMOI 3L7ZB 2E5LI 3HULA 4X64E 5IT9Q 4JI1E 1N32I 1H7UA 3K17A 1NZ0A 2O1TA 2Z5BB 2O1VA 4X64I 4UT4A 4JI1I 2HKEA 4U3BA 4IZJD 4NXME 4LF8E 2UU9E 4NXMI 4LF8I 5GMDA 2UU9I 4IFDE 4JV5E 4X66E 4OKGA 4JV5I 1H74A 5JEAD 4X66I 2C39B 4RPFA 4OX9E 2Z5CA 4OO1C 3GLLA 2JEAA 2R42A 4OX9I 1KVKA 4DV3E 2IOPA 1Y4SA 1Y5YA 1FJGE 5DRPA 2IERA 4DV3I 5DNLA 1XMQE 1VISA 2UUCE 1FJGI 1XMQI 2UUCI 2A2DA 2V8PA 2PNMA 4NXNE 5DNXA 3JAMQ 1PIEA 3Q6MA 4LF6I 1H7SA 1Z5BA 1N36E 4LFCE 4DV1I 4OO1F 4WUDA 5L3JA 2V34A 4LFCI 2NPFA 1N36I 2UXCE 2E1RA 1B62A 5LMUE 2Z5EA 4YHHE 1XNQI 2J7KA 4AIMA 4K0KE 2UXCI 5LMUI 2PO1B 4YHHI 4K0KI 3GONA 1KTVA 2UXBI 2IESA 4JI3E 2C38A 1MG7A 4GKJE 2GO4A 4HACB 3LTOA 4J3DA 4JI3I 4BA2B 2ZM6E 4GKJI 4DV6E 2VQEE 4U3DA 1FNMA 2GS8A 3B78A 2JT2A 2ZM6I 1ZM9A 3P3CA 4MDTA 2VQEI 4DV6I 4B3TE 4OO1A 5EKWA 4DR2E 3PYEA 2UXDE 3T1HE 4B3TI 3ZKBA 5DRRA 4JI5I 4LF4E 1K47A 4DR2I 1UDSA 2UXDI 2PO0A 3PRYA 1OYRA 2GQ0A 4LF4I 4IFDD 5K36D 1HNZE 3P3EA 1BKNA 1I94E 1HNZI 1IBME 3J7AG 3V5RA 1I94I 3J81Q 2JE6B 4IFDA 1HR0E 1N33E 4DU8A 4MU3A 4IZKA 1IBMI 2WNRA 1HR0I 1N34E 3M7ND 1N33I 2VF3A 1A6FA 4MU1A 1N34I 4LF5I 3LPSA 4FW9A 3ZZUA 4B3ME 1XHKA 4AM3A 2ZBKB 1UDOA 2C37A
chains in the Genus database with same CATH topology
2F1DA 5DNXA 4QNKA 4GQUA 4MU1A 4LPFA 4MU3A 4QNJA 1RHYA 5EKWA 5DNLA 5ELWA 5EL9A 2AE8A 4MU0A 4MU4A 4LOMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F1D A;  5DNX A;  4QNK A;  4GQU A;  4MU1 A;  4LPF A;  4MU3 A;  4QNJ A;  1RHY A;  5EKW A;  5DNL A;  5ELW A;  5EL9 A;  2AE8 A;  4MU0 A;  4MU4 A;  4LOM A; 
#chains in the Genus database with same CATH topology
 1XXE A;  1RRE A;  3QT8 A;  1UDQ A;  4KHP E;  4ED4 A;  3ZKD A;  1P42 A;  1UEK A;  4KHP I;  3U1Y A;  1OJ4 A;  2VES A;  3B82 A;  1KIJ A;  4OO1 E;  2AJ4 A;  1PKP A;  2C39 A;  1N32 E;  1R6M A;  1NHJ A;  2NN6 B;  4NBQ A;  2Q2E B;  3CDI A;  3HKM A;  3J80 C;  4JI0 I;  3P3G A;  4R1F A;  2BA0 G;  3U1K A;  3J80 Q;  2BA1 D;  4MU4 A;  1RR9 A;  2HHH E;  4BA1 A;  4KQV A;  5EL9 A;  2HHH I;  5C0X B;  4LFB E;  5DRO A;  1ZXM A;  3PS1 A;  3H1C A;  4LFB I;  2NN6 E;  2BR2 A;  1YH8 A;  4USM A;  2CGE A;  3P76 A;  5FWK A;  2V2Q A;  1MX0 A;  4HXZ A;  5FLX C;  5ELW A;  2PO1 A;  4LF6 E;  2GO3 A;  3CDJ A;  4PU9 A;  1EI1 A;  4LF9 I;  1D6T A;  4HY1 A;  4DV1 E;  5C0X E;  2ZIT A;  1NHH A;  1USV A;  2BV3 A;  1KKH A;  1XNQ E;  2CVE A;  2NN6 C;  4QNJ A;  3PYF A;  3OTO I;  2UXB E;  4IZJ B;  1Z0E A;  2PO2 B;  3WU6 A;  4OO1 D;  4DXL A;  2UUA E;  3K1J A;  4USK A;  2X36 A;  4GKK E;  2JE6 A;  4YY3 E;  2UUA I;  5JEA B;  4DR6 E;  4GKK I;  2PNL A;  4YY3 I;  5C0X C;  4JI5 E;  4URL A;  2XEX A;  4B3S E;  4DR6 I;  1N0V C;  1E3H A;  4B3S I;  2NN6 F;  2X7I A;  4PRX A;  3Q6N A;  3ZZ0 A;  4FN5 A;  1H72 C;  5A2Q C;  2BA1 G;  2WW4 A;  4FW6 A;  5K36 F;  4GQU A;  2CG9 A;  2V2Z A;  2R3V A;  4ZVI A;  1S4E A;  4MYT A;  2LJP A;  2HK3 A;  4JYA E;  4LF5 E;  2PNZ A;  4MQY A;  5C0X F;  5LMN E;  4JYA I;  2OI2 A;  4MYU A;  4I3H A;  1Z0W A;  2BM0 A;  4DV7 E;  3L7Z A;  4DPT A;  5LMN I;  2NN6 A;  4DV7 I;  3V2U C;  2Z5B A;  1WUU A;  3CWV A;  4LCH A;  5GME A;  4DPY A;  2HFS A;  4ISA A;  2VQF E;  2J65 A;  1FWL A;  2VQF I;  4DU7 A;  2F1D A;  1QZR A;  1H73 A;  4JI4 I;  1Z0B A;  5JEA C;  5IWA I;  4DPW A;  5C0X A;  2A2C A;  4JI0 E;  4FW5 A;  1EA6 A;  4XTJ A;  4DPX A;  4FW4 A;  4EMD A;  4IFD B;  4N3O A;  5K36 B;  4MU0 A;  5DRQ A;  4AID A;  3QT7 A;  1ZM4 A;  2DEJ A;  3PYG A;  2AE8 A;  5IT9 C;  2JEB B;  1Z5C A;  1FKA E;  5JEA F;  2C37 B;  2WP8 B;  4FWH A;  1Z5A A;  1IBK E;  1OYP A;  3NZK A;  1IBK I;  1J5E E;  1U2R A;  4JG4 A;  3LNU A;  2V2V A;  2DEI A;  1J5E I;  3WU5 A;  5K36 E;  4B3R E;  4IZJ A;  1IBL E;  4JI7 E;  3M85 D;  4LF9 E;  2PO2 A;  5FLX Q;  1ELO A;  4B3R I;  1MU5 A;  1VI7 A;  4DR1 E;  1IBL I;  4JI7 I;  4FW3 A;  3M7N G;  1FWK A;  3ZM7 A;  4DR3 E;  4HAC A;  4DR1 I;  1NHI A;  4BA2 A;  4Z7C A;  3PS2 A;  4DR3 I;  5JEA A;  4LOM A;  4M1K A;  1RHY A;  1HNW E;  3OTO E;  3WU3 A;  3JAM C;  4LFA E;  3ZZT A;  1HNW I;  1YHC A;  4BA1 B;  1ZM2 A;  4LFA I;  4IFD C;  4DV0 E;  4NXN I;  5K36 C;  4PRV A;  4DUZ E;  4AQY E;  5BR8 E;  2Z5C B;  1B63 A;  4DPU A;  4DV0 I;  4DUZ I;  4AQY I;  2BM1 A;  5BR8 I;  2JEA B;  4DR4 E;  2BR2 B;  1Z0C A;  4LCF A;  4DR4 I;  1Z0T A;  1PVG A;  4DV4 E;  4JI6 E;  5LL6 R;  3QT5 A;  2O1U A;  4HYM A;  4LPF A;  3K85 A;  4DV4 I;  1HNX E;  4JI6 I;  1Z0G A;  2EFG A;  3GCM A;  2BA0 D;  1HNX I;  4FWG A;  1ZM3 A;  1E3P A;  4IFD F;  4OZE A;  4QNK A;  3B4T A;  4P52 A;  5A2Q Q;  3WU4 A;  2HK2 A;  4X65 E;  4DUY E;  4DV2 E;  2NN6 D;  4LCG A;  4X65 I;  4Z7Y A;  4DUY I;  4DR5 E;  1S16 A;  5JEA E;  2O3Z A;  4DV2 I;  3T1Y E;  4DR5 I;  3T1H I;  2HFU A;  3T1Y I;  3D4J A;  4WUC A;  1HK7 A;  3H4L A;  2O1W A;  3PS3 A;  4FW7 A;  3DD6 A;  4FWD A;  3J81 C;  2C38 B;  1OYS A;  1Y6Z A;  3J7A M;  1R6L A;  4JI8 E;  5K36 A;  3M85 G;  5C0X D;  4LF7 E;  4OO1 B;  4JI8 I;  1DAR A;  4JI4 E;  3HJC A;  1Z59 A;  4IS9 A;  3M6A A;  4UTG A;  3F0N A;  2CZ9 A;  1ZXN A;  3UHM A;  3KRN A;  5IWA E;  4LF7 I;  2PO0 B;  2JEB A;  4DR7 E;  4P7A A;  3P06 A;  4X62 E;  2UUB E;  2F4V E;  1FI4 A;  4DR7 I;  3QT6 A;  3GME A;  4B3M I;  3PYD A;  4X62 I;  2UUB I;  4JI2 E;  2F4V I;  3B8H A;  2WP8 A;  4JI2 I;  1Y60 A;  1N0U A;  1USU A;  1UDN A;  4IZK B;  1XNR E;  3Q1Q A;  2WNR B;  1Z0V A;  2HKJ A;  4DV5 E;  1XNR I;  2PNZ B;  1Y4U A;  2IOQ A;  1XMO E;  2E5L E;  4DV5 I;  4WUB A;  1XMO I;  3L7Z B;  2E5L I;  3HUL A;  4X64 E;  5IT9 Q;  4JI1 E;  1N32 I;  1H7U A;  3K17 A;  1NZ0 A;  2O1T A;  2Z5B B;  2O1V A;  4X64 I;  4UT4 A;  4JI1 I;  2HKE A;  4U3B A;  4IZJ D;  4NXM E;  4LF8 E;  2UU9 E;  4NXM I;  4LF8 I;  5GMD A;  2UU9 I;  4IFD E;  4JV5 E;  4X66 E;  4OKG A;  4JV5 I;  1H74 A;  5JEA D;  4X66 I;  2C39 B;  4RPF A;  4OX9 E;  2Z5C A;  4OO1 C;  3GLL A;  2JEA A;  2R42 A;  4OX9 I;  1KVK A;  4DV3 E;  2IOP A;  1Y4S A;  1Y5Y A;  1FJG E;  5DRP A;  2IER A;  4DV3 I;  5DNL A;  1XMQ E;  1VIS A;  2UUC E;  1FJG I;  1XMQ I;  2UUC I;  2A2D A;  2V8P A;  2PNM A;  4NXN E;  5DNX A;  3JAM Q;  1PIE A;  3Q6M A;  4LF6 I;  1H7S A;  1Z5B A;  1N36 E;  4LFC E;  4DV1 I;  4OO1 F;  4WUD A;  5L3J A;  2V34 A;  4LFC I;  2NPF A;  1N36 I;  2UXC E;  2E1R A;  1B62 A;  5LMU E;  2Z5E A;  4YHH E;  1XNQ I;  2J7K A;  4AIM A;  4K0K E;  2UXC I;  5LMU I;  2PO1 B;  4YHH I;  4K0K I;  3GON A;  1KTV A;  2UXB I;  2IES A;  4JI3 E;  2C38 A;  1MG7 A;  4GKJ E;  2GO4 A;  4HAC B;  3LTO A;  4J3D A;  4JI3 I;  4BA2 B;  2ZM6 E;  4GKJ I;  4DV6 E;  2VQE E;  4U3D A;  1FNM A;  2GS8 A;  3B78 A;  2JT2 A;  2ZM6 I;  1ZM9 A;  3P3C A;  4MDT A;  2VQE I;  4DV6 I;  4B3T E;  4OO1 A;  5EKW A;  4DR2 E;  3PYE A;  2UXD E;  3T1H E;  4B3T I;  3ZKB A;  5DRR A;  4JI5 I;  4LF4 E;  1K47 A;  4DR2 I;  1UDS A;  2UXD I;  2PO0 A;  3PRY A;  1OYR A;  2GQ0 A;  4LF4 I;  4IFD D;  5K36 D;  1HNZ E;  3P3E A;  1BKN A;  1I94 E;  1HNZ I;  1IBM E;  3J7A G;  3V5R A;  1I94 I;  3J81 Q;  2JE6 B;  4IFD A;  1HR0 E;  1N33 E;  4DU8 A;  4MU3 A;  4IZK A;  1IBM I;  2WNR A;  1HR0 I;  1N34 E;  3M7N D;  1N33 I;  2VF3 A;  1A6F A;  4MU1 A;  1N34 I;  4LF5 I;  3LPS A;  4FW9 A;  3ZZU A;  4B3M E;  1XHK A;  4AM3 A;  2ZBK B;  1UDO A;  2C37 A; 
#chains in the Genus database with same CATH homology
 2F1D A;  5DNX A;  4QNK A;  4GQU A;  4MU1 A;  4LPF A;  4MU3 A;  4QNJ A;  1RHY A;  5EKW A;  5DNL A;  5ELW A;  5EL9 A;  2AE8 A;  4MU0 A;  4MU4 A;  4LOM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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