1FKHA

Design, synthesis, and kinetic evaluation of high-affinity fkbp ligands, and the x-ray crystal structures of their complexes with fkbp12
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
107
structure length
107
Chain Sequence
GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
pubmed rcsb
molecule tags Cis-trans isomerase
source organism Homo sapiens
molecule keywords FK506 BINDING PROTEIN
total genus 27
structure length 107
sequence length 107
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 1993-08-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00254 FKBP_C FKBP-type peptidyl-prolyl cis-trans isomerase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.50.40 Alpha Beta Roll Chitinase A; domain 3 Chitinase A; domain 3 1fkhA00
4TNSA 1NSGA 1QZ2A 1ZCNA 3O5LA 2LPVA 2VCDA 4U85A 3JYMA 3TC5A 2XP8A 4DROA 3KABA 4GIVA 4NNRA 1Y0OA 1N1AA 2M1IA 3IK8A 1R9HA 1JNTA 1QPLA 3O5DA 3RFWA 3TCZA 1FKDA 5HW6A 1P5QA 1PINA 3I6CA 4ODPA 2PV1A 1FD9A 1FKGA 4IQ2A 2DG3A 1QPFA 1C9HA 2KGJA 4TW8A 3UI5A 4ODKA 3UI4A 1D7IA 3NI6A 3EY6A 2F4EA 3KAGA 1YATA 2RURA 1FKHA 2DG4A 2F21A 2RUQA 4JFLA 4U84A 3WH0A 2PPOA 2RSEA 1NMWA 1J4IA 3IHZA 3O5OA 4U86A 3GPKA 2D9FA 2M2AA 3B7XA 2L2SA 4DT4A 2XP4A 2KE0A 3PRBA 4GGQA 1D7HA 4QIBA 2MLZA 3MDYB 2PPPA 4ODNA 3JYJA 1W26A 1ROUA 2K8IA 1D7JA 4ODOA 4TYOA 1JVWA 1Q6UA 3KAIA 4W9OA 3NRKA 2MPHA 2JZVA 4G2PA 2KI3A 3H9RB 1JNSA 3O5IA 1FKFA 1J4RA 5B8IC 3O5QA 4MSPA 4TW7A 5HUAA 3IKGA 3O5EA 1FKJA 5D75A 3UQAA 1KT0A 2XP9A 4JFJA 2AWGA 4LAVA 5HT1A 3UQBA 1FKRA 4FN2A 4DRNA 2VN1A 3VAWA 2XP6A 2MLYA 2ZR5A 3O5PA 4DRQA 5HWBA 1A7XA 2F2DA 2KR7A 1FAPA 2ITKA 3O5FA 1FKKA 4DRJA 4O2TA 4QT3A 2ZR4A 4W9QA 2XP7A 2PPNA 5HW8A 2N87A 4ODQA 5DIUA 4DH0A 2Q5AA 3UQIA 1BKFA 2Y78A 5HWCA 3KAHA 4TX0A 2OFNA 4G50A 2DG9A 2MF9A 4JFIA 3O5JA 4JYSA 3O5GA 1EQ3A 4ITZA 3KAFA 3RGCA 3CGNA 4J4OA 1FKIA 2MNTA 3IKDA 4J4NA 2M08A 4LAXA 3UF8A 3O5KA 1BL4A 4LAYA 1TCOC 1HXVA 1D6OA 4DRPA 4MGVA 4C02B 1ZK6A 5HKGA 4DRHA 2PBCA 1NMVA 3O5RA 5GPGA 3O5MA 1U79A 3NTPA 1Q1CA 2LKNA 5DITA 1PBKA 4DRMA 1F40A 1Q6HA 4ODMA 1ROTA 3KCEA 3FAPA 2PV3A 2XP5A 3KACA 4QT2A 2XPBA 3CGMA 1FKTA 5HW7A 4IPXA 3PRDA 4ODRA 4DIPA 4ODLA 2IF4A 2XP3A 1FKBA 5HTGA 2LGOA 2XPAA 1T11A 4R0XA 1F8AB 3TDBA 1KT1A 4TW6A 2KO7A 4N19A 2RUDA 2RQSA 4BF8A 1FJDA 3JXVA 2ZQTA 3PA7A 2RUCA 2ZQSA 1J6YA 4W9PA 2MLXA 1Q6IA 5I98A 1FKSA 2FKEA 3KZ7A 4DZ2A 3OOBA 1J4HA 5J6EA 2ZR6A 4DRKA 3ODKA 2ZQUA 4DRIA 2KFWA 4JFMA 1YW5A 5DIVA 4FAPA 1L1PA 1M5YA 2UZ5A 4JFKA 4LAWA 4DZ3A 2ZQVA 3UI6A 1B6CA 1FKLA 1EYMA 3LUOA 5BXJA 2LJ4A 4IQCA 2FAPA 2PV2A 3KADA
chains in the Genus database with same CATH superfamily
4TNSA 2VCDA 1JCHB 1IX5A 2XP8A 2G8ZA 1Y0OA 1N1AA 1ZBVA 1QPLA 3ARUA 4ZS6A 1H0GA 1PINA 3I6CA 3WQVA 3CZ8A 3PR9A 4MPKA 2F21A 4DWSA 5JH8A 1J4IA 3O5OA 4QZVB 1EHNA 4DT4A 2XP4A 4IT4A 4WJXA 2KE0A 4ODNA 3JYJA 1NH6A 1ROUA 2DSVA 4W9OA 1JVWA 2B31A 2PI6A 2EULA 3O5IA 3PRAA 4TW7A 2IUZA 3IKGA 3O5EA 1NWRA 4P8WA 3UQBA 4ZPTR 2MLYA 1K9TA 5HWBA 2DT2A 5HW8A 2N87A 5DIUA 1ZL1A 1HKIA 4Z2HA 2MF9A 3O5JA 4WKAA 3KAFA 4J4OA 4LAXA 2A3EA 2M08A 3O5KA 1TCOC 1ZBKA 1ZK6A 2AOSA 3EIPA 3WD0A 1NMVA 5DITA 4MTVA 3KACA 3CGMA 5DO2A 2IF4A 2XP3A 5HTGA 1T11A 1F8AB 4PTMA 3AS2A 3PA7A 1GUVA 4WKHA 2MLXA 5HBFA 3CHFA 3WKZA 2FKEA 4AY1A 1HJVA 3BXWA 2ZR6A 2KFWA 4IT6A 5DIVA 2DSZA 4FAPA 1L1PA 1M5YA 4DZ3A 1FKLA 1W9VA 2LJ4A 3RM4A 2FAPA 2PV2A 1W1YA 1ZCNA 2LPVA 3TC5A 4DROA 3KABA 1GRJA 2M1IA 4S3KA 3RFWA 3TCZA 3B9AA 1FKDA 2PV1A 3AS0A 4P8XA 4IQ2A 2DG3A 1QPFA 4TW8A 1NWTA 1D7IA 4P8VA 3KAGA 1FKHA 4JFLA 1XHGA 4U84A 1HKKA 2PPOA 2A3BA 3ARVA 4W5UA 3WD1A 4U86A 2M2AA 1LL7A 1E9LA 1OWQA 4LGXA 3PRBA 5DF0A 4ODOA 2K8IA 1D7JA 1WNOA 3NRKA 2MPHA 2JZVA 5DEZA 2KI3A 3H9RB 1E6PA 1W1PA 4MSPA 1GPFA 1W9PA 2OLHA 3ALFA 1FKJA 4DWSC 2XP9A 1FKRA 1E15A 4FN2A 2VN1A 3VAWA 2XP6A 2ZR5A 3O5PA 4Z2LA 3ARYA 2F2DA 3O5FA 4MNLA 2XP7A 2PPNA 4ODQA 4DH0A 1BKFA 1NWSA 3ARXA 4MNKA 4TX0A 3AS1A 2OFNA 1ZU8A 3ARWA 3CHCA 3WIJA 4DWSB 4JFIA 4JYSA 1X6NA 3O5GA 1XRVA 1EQ3A 3RGCA 4XAKA 4J4NA 3B9EA 3FY1A 3ARPA 3UF8A 4LAYA 1HXVA 1O6IA 3O5MA 1U79A 3NTPA 1Q1CA 2LKNA 1PBKA 1Q6HA 4UDMA 3KCEA 2XP5A 1GOIA 3CHEA 4QT2A 4Z2KA 1FKBA 4S3JA 2WK2A 2ESCA 4R5EA 2KO7A 2RUDA 1E6RA 2RQSA 4BF8A 1FJDA 2RUCA 4W9PA 5I98A 1W1VA 1FKSA 1OGBA 3OOBA 2O9OA 5J6EA 2WLZA 3ODKA 1YW5A 1LL6A 2UZ5A 4JFKA 1NWUA 3KADA 1HKMA 4NNRA 1D2KA 1R9HA 1JNTA 2A3CA 4Q7NA 1P5QA 4ODPA 3GU0A 1FD9A 1OGGA 1FKGA 3UI4A 1W9UA 3EY6A 3AS3A 3CHDA 2DT0A 2RURA 3WH0A 2RSEA 1NMWA 3IHZA 3RMEA 3WL1A 3WD2A 3B7XA 2DSWA 3WD3A 4GGQA 1W1TA 2MLZA 3G6MA 2DT3A 3KAIA 4MAVA 1LQ0A 1JNSA 4DWSD 4Q22A 5HUAA 3RM9A 5D75A 1EDQA 1KT0A 4JFJA 2AWGA 4Z2JA 5HT1A 3B9DA 4Z2GA 1E6ZA 2KR7A 1FAPA 2ITKA 1FKKA 4O2TA 2ZR4A 3W4RA 2Q5AA 3UQIA 2Y78A 5HWCA 3KAHA 4L3NA 4ZPVR 4G50A 4ITZA 1X6LA 3CGNA 3IKDA 2MNTA 3RM8A 4Z2IA 4WK9A 2FDMA 1SR0A 5HKGA 2PBCA 3GTYX 4ML4A 1JNDA 4DRMA 4ODMA 1ROTA 1SYTA 2PV3A 5GQBA 3AQUA 1FKTA 5HW7A 4ODRA 4MNJA 1KT1A 4N19A 3ARZA 4KR0B 1J6YA 2O92A 2DSUA 2ZQTA 2ZQSA 1Q6IA 1RD6A 4L72B 2YBUA 4ZPWR 1UR8A 2ZQUA 4DRIA 3G6LA 4JFMA 1UR9A 4WIWA 4HBOA 1WB0A 1B6CA 1EYMA 3LUOA 5BXJA 4IQCA 2DPEA 1NSGA 1QZ2A 3O5LA 4U85A 1HJXA 3JYMA 2QF8A 4GIVA 3IK8A 3O5DA 1HJWA 5HW6A 3ARQA 3UI5A 2KGJA 1C9HA 4ODKA 1VF8A 3NI6A 4MNMA 3BMBA 2F4EA 4NZCA 4HBEA 1YATA 5GPRA 2DG4A 2RUQA 3GPKA 2D9FA 4URIA 2L2SA 4HARA 1D7HA 4KQZA 4QIBA 1ZBWA 3MDYB 2PPPA 1W26A 1LJYA 4TYOA 1Q6UA 4G2PA 1E6NA 1FFQA 3ARTA 1FKFA 1J4RA 2ETNA 2P4VA 3CH9A 5B8IC 3O5QA 3ARRA 3OA5A 1JNEA 3UQAA 2WM0A 1ZB5A 4LAVA 4DRNA 4DRQA 2A3AA 1A7XA 1WAWA 1ITXA 4DRJA 4QT3A 4W9QA 1H0IA 3AROA 1E44A 2DG9A 1LG2A 4WKFA 3WD4A 1FKIA 1BL4A 1D6OA 4DRPA 4MGVA 4C02B 4DRHA 3O5RA 5GPGA 1F40A 2YBTA 3FAPA 1LL4A 1EIBA 2XPBA 2DT1A 4IPXA 3PRDA 2WLYA 4DIPA 4ODLA 2B5UB 2LGOA 2XPAA 4R0XA 3TDBA 4TW6A 3JXVA 2G41A 1KFWA 3ARSA 3B8SA 2F23A 3KZ7A 4DZ2A 1CTNA 1J4HA 1TFVA 2PN0A 4DRKA 3QOKA 4NSBA 3ALGA 1LG1A 1FFRA 4LAWA 3WL0A 2ZQVA 3UI6A 3FXYA 3WQWA 1ZBCA 4P8UA 1HKJA
chains in the Genus database with same CATH topology
4TNSA 2VCDA 1IX5A 2XP8A 2G8ZA 1Y0OA 1N1AA 1ZBVA 1QPLA 3ARUA 4ZS6A 1H0GA 1PINA 3I6CA 3WQVA 3CZ8A 3PR9A 4MPKA 2F21A 4DWSA 5JH8A 1J4IA 3O5OA 4QZVB 1EHNA 4DT4A 2XP4A 4IT4A 4WJXA 2KE0A 4ODNA 3JYJA 1NH6A 1ROUA 2DSVA 4W9OA 1JVWA 2B31A 2PI6A 3O5IA 3PRAA 4TW7A 2IUZA 3IKGA 3O5EA 1NWRA 4P8WA 3UQBA 4ZPTR 2MLYA 1K9TA 5HWBA 2DT2A 5HW8A 2N87A 5DIUA 1ZL1A 1HKIA 4Z2HA 2MF9A 3O5JA 4WKAA 3KAFA 4J4OA 4LAXA 2A3EA 2M08A 3O5KA 1TCOC 1ZBKA 1ZK6A 2AOSA 3WD0A 1NMVA 5DITA 4MTVA 3KACA 3CGMA 5DO2A 2IF4A 2XP3A 5HTGA 1T11A 1F8AB 4PTMA 3AS2A 3PA7A 1GUVA 4WKHA 2MLXA 5HBFA 3CHFA 3WKZA 2FKEA 4AY1A 1HJVA 3BXWA 2ZR6A 2KFWA 4IT6A 5DIVA 2DSZA 4FAPA 1L1PA 1M5YA 4DZ3A 1FKLA 1W9VA 2LJ4A 3RM4A 2FAPA 2PV2A 1W1YA 1ZCNA 2LPVA 3TC5A 4DROA 3KABA 2M1IA 4S3KA 3RFWA 3TCZA 3B9AA 1FKDA 2PV1A 3AS0A 4P8XA 4IQ2A 2DG3A 1QPFA 4TW8A 1NWTA 1D7IA 4P8VA 3KAGA 1FKHA 4JFLA 1XHGA 4U84A 1HKKA 2PPOA 2A3BA 3ARVA 4W5UA 3WD1A 4U86A 2M2AA 1LL7A 1E9LA 1OWQA 4LGXA 3PRBA 5DF0A 4ODOA 2K8IA 1D7JA 1WNOA 3NRKA 2MPHA 2JZVA 5DEZA 2KI3A 3H9RB 1E6PA 1W1PA 4MSPA 1GPFA 1W9PA 2OLHA 3ALFA 1FKJA 4DWSC 2XP9A 1FKRA 1E15A 4FN2A 2VN1A 3VAWA 2XP6A 2ZR5A 3O5PA 4Z2LA 3ARYA 2F2DA 3O5FA 4MNLA 2XP7A 2PPNA 4ODQA 4DH0A 1BKFA 1NWSA 3ARXA 4MNKA 4TX0A 3AS1A 2OFNA 1ZU8A 3ARWA 3CHCA 3WIJA 4DWSB 4JFIA 4JYSA 1X6NA 3O5GA 1XRVA 1EQ3A 3RGCA 4XAKA 4J4NA 3B9EA 3FY1A 3ARPA 3UF8A 4LAYA 1HXVA 1O6IA 3O5MA 1U79A 3NTPA 1Q1CA 2LKNA 1PBKA 1Q6HA 3KCEA 2XP5A 1GOIA 3CHEA 4QT2A 4Z2KA 1FKBA 4S3JA 2WK2A 2ESCA 4R5EA 2KO7A 2RUDA 1E6RA 2RQSA 4BF8A 1FJDA 2RUCA 4W9PA 5I98A 1W1VA 1FKSA 1OGBA 3OOBA 2O9OA 5J6EA 2WLZA 3ODKA 1YW5A 1LL6A 2UZ5A 4JFKA 1NWUA 3KADA 1HKMA 4NNRA 1D2KA 1R9HA 1JNTA 2A3CA 4Q7NA 1P5QA 4ODPA 1FD9A 1OGGA 1FKGA 3UI4A 1W9UA 3EY6A 3AS3A 3CHDA 2DT0A 2RURA 3WH0A 2RSEA 1NMWA 3IHZA 3RMEA 3WL1A 3WD2A 3B7XA 2DSWA 3WD3A 4GGQA 1W1TA 2MLZA 3G6MA 2DT3A 3KAIA 4MAVA 1LQ0A 1JNSA 4DWSD 4Q22A 5HUAA 3RM9A 5D75A 1EDQA 1KT0A 4JFJA 2AWGA 4Z2JA 5HT1A 3B9DA 4Z2GA 1E6ZA 2KR7A 1FAPA 2ITKA 1FKKA 4O2TA 2ZR4A 3W4RA 2Q5AA 3UQIA 2Y78A 5HWCA 3KAHA 4L3NA 4ZPVR 4G50A 4ITZA 1X6LA 3CGNA 3IKDA 2MNTA 3RM8A 4Z2IA 4WK9A 2FDMA 1SR0A 5HKGA 2PBCA 4ML4A 1JNDA 4DRMA 4ODMA 1ROTA 1SYTA 2PV3A 5GQBA 3AQUA 1FKTA 5HW7A 4ODRA 4MNJA 1KT1A 4N19A 3ARZA 4KR0B 1J6YA 2O92A 2DSUA 2ZQTA 2ZQSA 1Q6IA 1RD6A 4L72B 2YBUA 4ZPWR 1UR8A 2ZQUA 4DRIA 3G6LA 4JFMA 1UR9A 4WIWA 4HBOA 1WB0A 1B6CA 1EYMA 3LUOA 5BXJA 4IQCA 2DPEA 1NSGA 1QZ2A 3O5LA 4U85A 1HJXA 3JYMA 2QF8A 4GIVA 3IK8A 3O5DA 1HJWA 5HW6A 3ARQA 3UI5A 2KGJA 1C9HA 4ODKA 1VF8A 3NI6A 4MNMA 2F4EA 4NZCA 4HBEA 1YATA 5GPRA 2DG4A 2RUQA 3GPKA 2D9FA 4URIA 2L2SA 4HARA 1D7HA 4KQZA 4QIBA 1ZBWA 3MDYB 2PPPA 1W26A 1LJYA 4TYOA 1Q6UA 4G2PA 1E6NA 1FFQA 3ARTA 1FKFA 1J4RA 3CH9A 5B8IC 3O5QA 3ARRA 3OA5A 1JNEA 3UQAA 2WM0A 1ZB5A 4LAVA 4DRNA 4DRQA 2A3AA 1A7XA 1WAWA 1ITXA 4DRJA 4QT3A 4W9QA 1H0IA 3AROA 2DG9A 1LG2A 4WKFA 3WD4A 1FKIA 1BL4A 1D6OA 4DRPA 4MGVA 4C02B 4DRHA 3O5RA 5GPGA 1F40A 2YBTA 3FAPA 1LL4A 1EIBA 2XPBA 2DT1A 4IPXA 3PRDA 2WLYA 4DIPA 4ODLA 2LGOA 2XPAA 4R0XA 3TDBA 4TW6A 3JXVA 2G41A 1KFWA 3ARSA 3B8SA 3KZ7A 4DZ2A 1CTNA 1J4HA 1TFVA 4DRKA 3QOKA 4NSBA 3ALGA 1LG1A 1FFRA 4LAWA 3WL0A 2ZQVA 3UI6A 3FXYA 3WQWA 1ZBCA 4P8UA 1HKJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TNS A;  1NSG A;  1QZ2 A;  1ZCN A;  3O5L A;  2LPV A;  2VCD A;  4U85 A;  3JYM A;  3TC5 A;  2XP8 A;  4DRO A;  3KAB A;  4GIV A;  4NNR A;  1Y0O A;  1N1A A;  2M1I A;  3IK8 A;  1R9H A;  1JNT A;  1QPL A;  3O5D A;  3RFW A;  3TCZ A;  1FKD A;  5HW6 A;  1P5Q A;  1PIN A;  3I6C A;  4ODP A;  2PV1 A;  1FD9 A;  1FKG A;  4IQ2 A;  2DG3 A;  1QPF A;  1C9H A;  2KGJ A;  4TW8 A;  3UI5 A;  4ODK A;  3UI4 A;  1D7I A;  3NI6 A;  3EY6 A;  2F4E A;  3KAG A;  1YAT A;  2RUR A;  1FKH A;  2DG4 A;  2F21 A;  2RUQ A;  4JFL A;  4U84 A;  3WH0 A;  2PPO A;  2RSE A;  1NMW A;  1J4I A;  3IHZ A;  3O5O A;  4U86 A;  3GPK A;  2D9F A;  2M2A A;  3B7X A;  2L2S A;  4DT4 A;  2XP4 A;  2KE0 A;  3PRB A;  4GGQ A;  1D7H A;  4QIB A;  2MLZ A;  3MDY B;  2PPP A;  4ODN A;  3JYJ A;  1W26 A;  1ROU A;  2K8I A;  1D7J A;  4ODO A;  4TYO A;  1JVW A;  1Q6U A;  3KAI A;  4W9O A;  3NRK A;  2MPH A;  2JZV A;  4G2P A;  2KI3 A;  3H9R B;  1JNS A;  3O5I A;  1FKF A;  1J4R A;  5B8I C;  3O5Q A;  4MSP A;  4TW7 A;  5HUA A;  3IKG A;  3O5E A;  1FKJ A;  5D75 A;  3UQA A;  1KT0 A;  2XP9 A;  4JFJ A;  2AWG A;  4LAV A;  5HT1 A;  3UQB A;  1FKR A;  4FN2 A;  4DRN A;  2VN1 A;  3VAW A;  2XP6 A;  2MLY A;  2ZR5 A;  3O5P A;  4DRQ A;  5HWB A;  1A7X A;  2F2D A;  2KR7 A;  1FAP A;  2ITK A;  3O5F A;  1FKK A;  4DRJ A;  4O2T A;  4QT3 A;  2ZR4 A;  4W9Q A;  2XP7 A;  2PPN A;  5HW8 A;  2N87 A;  4ODQ A;  5DIU A;  4DH0 A;  2Q5A A;  3UQI A;  1BKF A;  2Y78 A;  5HWC A;  3KAH A;  4TX0 A;  2OFN A;  4G50 A;  2DG9 A;  2MF9 A;  4JFI A;  3O5J A;  4JYS A;  3O5G A;  1EQ3 A;  4ITZ A;  3KAF A;  3RGC A;  3CGN A;  4J4O A;  1FKI A;  2MNT A;  3IKD A;  4J4N A;  2M08 A;  4LAX A;  3UF8 A;  3O5K A;  1BL4 A;  4LAY A;  1TCO C;  1HXV A;  1D6O A;  4DRP A;  4MGV A;  4C02 B;  1ZK6 A;  5HKG A;  4DRH A;  2PBC A;  1NMV A;  3O5R A;  5GPG A;  3O5M A;  1U79 A;  3NTP A;  1Q1C A;  2LKN A;  5DIT A;  1PBK A;  4DRM A;  1F40 A;  1Q6H A;  4ODM A;  1ROT A;  3KCE A;  3FAP A;  2PV3 A;  2XP5 A;  3KAC A;  4QT2 A;  2XPB A;  3CGM A;  1FKT A;  5HW7 A;  4IPX A;  3PRD A;  4ODR A;  4DIP A;  4ODL A;  2IF4 A;  2XP3 A;  1FKB A;  5HTG A;  2LGO A;  2XPA A;  1T11 A;  4R0X A;  1F8A B;  3TDB A;  1KT1 A;  4TW6 A;  2KO7 A;  4N19 A;  2RUD A;  2RQS A;  4BF8 A;  1FJD A;  3JXV A;  2ZQT A;  3PA7 A;  2RUC A;  2ZQS A;  1J6Y A;  4W9P A;  2MLX A;  1Q6I A;  5I98 A;  1FKS A;  2FKE A;  3KZ7 A;  4DZ2 A;  3OOB A;  1J4H A;  5J6E A;  2ZR6 A;  4DRK A;  3ODK A;  2ZQU A;  4DRI A;  2KFW A;  4JFM A;  1YW5 A;  5DIV A;  4FAP A;  1L1P A;  1M5Y A;  2UZ5 A;  4JFK A;  4LAW A;  4DZ3 A;  2ZQV A;  3UI6 A;  1B6C A;  1FKL A;  1EYM A;  3LUO A;  5BXJ A;  2LJ4 A;  4IQC A;  2FAP A;  2PV2 A;  3KAD A; 
#chains in the Genus database with same CATH topology
 4TNS A;  2VCD A;  1JCH B;  1IX5 A;  2XP8 A;  2G8Z A;  1Y0O A;  1N1A A;  1ZBV A;  1QPL A;  3ARU A;  4ZS6 A;  1H0G A;  1PIN A;  3I6C A;  3WQV A;  3CZ8 A;  3PR9 A;  4MPK A;  2F21 A;  4DWS A;  5JH8 A;  1J4I A;  3O5O A;  4QZV B;  1EHN A;  4DT4 A;  2XP4 A;  4IT4 A;  4WJX A;  2KE0 A;  4ODN A;  3JYJ A;  1NH6 A;  1ROU A;  2DSV A;  4W9O A;  1JVW A;  2B31 A;  2PI6 A;  2EUL A;  3O5I A;  3PRA A;  4TW7 A;  2IUZ A;  3IKG A;  3O5E A;  1NWR A;  4P8W A;  3UQB A;  4ZPT R;  2MLY A;  1K9T A;  5HWB A;  2DT2 A;  5HW8 A;  2N87 A;  5DIU A;  1ZL1 A;  1HKI A;  4Z2H A;  2MF9 A;  3O5J A;  4WKA A;  3KAF A;  4J4O A;  4LAX A;  2A3E A;  2M08 A;  3O5K A;  1TCO C;  1ZBK A;  1ZK6 A;  2AOS A;  3EIP A;  3WD0 A;  1NMV A;  5DIT A;  4MTV A;  3KAC A;  3CGM A;  5DO2 A;  2IF4 A;  2XP3 A;  5HTG A;  1T11 A;  1F8A B;  4PTM A;  3AS2 A;  3PA7 A;  1GUV A;  4WKH A;  2MLX A;  5HBF A;  3CHF A;  3WKZ A;  2FKE A;  4AY1 A;  1HJV A;  3BXW A;  2ZR6 A;  2KFW A;  4IT6 A;  5DIV A;  2DSZ A;  4FAP A;  1L1P A;  1M5Y A;  4DZ3 A;  1FKL A;  1W9V A;  2LJ4 A;  3RM4 A;  2FAP A;  2PV2 A;  1W1Y A;  1ZCN A;  2LPV A;  3TC5 A;  4DRO A;  3KAB A;  1GRJ A;  2M1I A;  4S3K A;  3RFW A;  3TCZ A;  3B9A A;  1FKD A;  2PV1 A;  3AS0 A;  4P8X A;  4IQ2 A;  2DG3 A;  1QPF A;  4TW8 A;  1NWT A;  1D7I A;  4P8V A;  3KAG A;  1FKH A;  4JFL A;  1XHG A;  4U84 A;  1HKK A;  2PPO A;  2A3B A;  3ARV A;  4W5U A;  3WD1 A;  4U86 A;  2M2A A;  1LL7 A;  1E9L A;  1OWQ A;  4LGX A;  3PRB A;  5DF0 A;  4ODO A;  2K8I A;  1D7J A;  1WNO A;  3NRK A;  2MPH A;  2JZV A;  5DEZ A;  2KI3 A;  3H9R B;  1E6P A;  1W1P A;  4MSP A;  1GPF A;  1W9P A;  2OLH A;  3ALF A;  1FKJ A;  4DWS C;  2XP9 A;  1FKR A;  1E15 A;  4FN2 A;  2VN1 A;  3VAW A;  2XP6 A;  2ZR5 A;  3O5P A;  4Z2L A;  3ARY A;  2F2D A;  3O5F A;  4MNL A;  2XP7 A;  2PPN A;  4ODQ A;  4DH0 A;  1BKF A;  1NWS A;  3ARX A;  4MNK A;  4TX0 A;  3AS1 A;  2OFN A;  1ZU8 A;  3ARW A;  3CHC A;  3WIJ A;  4DWS B;  4JFI A;  4JYS A;  1X6N A;  3O5G A;  1XRV A;  1EQ3 A;  3RGC A;  4XAK A;  4J4N A;  3B9E A;  3FY1 A;  3ARP A;  3UF8 A;  4LAY A;  1HXV A;  1O6I A;  3O5M A;  1U79 A;  3NTP A;  1Q1C A;  2LKN A;  1PBK A;  1Q6H A;  4UDM A;  3KCE A;  2XP5 A;  1GOI A;  3CHE A;  4QT2 A;  4Z2K A;  1FKB A;  4S3J A;  2WK2 A;  2ESC A;  4R5E A;  2KO7 A;  2RUD A;  1E6R A;  2RQS A;  4BF8 A;  1FJD A;  2RUC A;  4W9P A;  5I98 A;  1W1V A;  1FKS A;  1OGB A;  3OOB A;  2O9O A;  5J6E A;  2WLZ A;  3ODK A;  1YW5 A;  1LL6 A;  2UZ5 A;  4JFK A;  1NWU A;  3KAD A;  1HKM A;  4NNR A;  1D2K A;  1R9H A;  1JNT A;  2A3C A;  4Q7N A;  1P5Q A;  4ODP A;  3GU0 A;  1FD9 A;  1OGG A;  1FKG A;  3UI4 A;  1W9U A;  3EY6 A;  3AS3 A;  3CHD A;  2DT0 A;  2RUR A;  3WH0 A;  2RSE A;  1NMW A;  3IHZ A;  3RME A;  3WL1 A;  3WD2 A;  3B7X A;  2DSW A;  3WD3 A;  4GGQ A;  1W1T A;  2MLZ A;  3G6M A;  2DT3 A;  3KAI A;  4MAV A;  1LQ0 A;  1JNS A;  4DWS D;  4Q22 A;  5HUA A;  3RM9 A;  5D75 A;  1EDQ A;  1KT0 A;  4JFJ A;  2AWG A;  4Z2J A;  5HT1 A;  3B9D A;  4Z2G A;  1E6Z A;  2KR7 A;  1FAP A;  2ITK A;  1FKK A;  4O2T A;  2ZR4 A;  3W4R A;  2Q5A A;  3UQI A;  2Y78 A;  5HWC A;  3KAH A;  4L3N A;  4ZPV R;  4G50 A;  4ITZ A;  1X6L A;  3CGN A;  3IKD A;  2MNT A;  3RM8 A;  4Z2I A;  4WK9 A;  2FDM A;  1SR0 A;  5HKG A;  2PBC A;  3GTY X;  4ML4 A;  1JND A;  4DRM A;  4ODM A;  1ROT A;  1SYT A;  2PV3 A;  5GQB A;  3AQU A;  1FKT A;  5HW7 A;  4ODR A;  4MNJ A;  1KT1 A;  4N19 A;  3ARZ A;  4KR0 B;  1J6Y A;  2O92 A;  2DSU A;  2ZQT A;  2ZQS A;  1Q6I A;  1RD6 A;  4L72 B;  2YBU A;  4ZPW R;  1UR8 A;  2ZQU A;  4DRI A;  3G6L A;  4JFM A;  1UR9 A;  4WIW A;  4HBO A;  1WB0 A;  1B6C A;  1EYM A;  3LUO A;  5BXJ A;  4IQC A;  2DPE A;  1NSG A;  1QZ2 A;  3O5L A;  4U85 A;  1HJX A;  3JYM A;  2QF8 A;  4GIV A;  3IK8 A;  3O5D A;  1HJW A;  5HW6 A;  3ARQ A;  3UI5 A;  2KGJ A;  1C9H A;  4ODK A;  1VF8 A;  3NI6 A;  4MNM A;  3BMB A;  2F4E A;  4NZC A;  4HBE A;  1YAT A;  5GPR A;  2DG4 A;  2RUQ A;  3GPK A;  2D9F A;  4URI A;  2L2S A;  4HAR A;  1D7H A;  4KQZ A;  4QIB A;  1ZBW A;  3MDY B;  2PPP A;  1W26 A;  1LJY A;  4TYO A;  1Q6U A;  4G2P A;  1E6N A;  1FFQ A;  3ART A;  1FKF A;  1J4R A;  2ETN A;  2P4V A;  3CH9 A;  5B8I C;  3O5Q A;  3ARR A;  3OA5 A;  1JNE A;  3UQA A;  2WM0 A;  1ZB5 A;  4LAV A;  4DRN A;  4DRQ A;  2A3A A;  1A7X A;  1WAW A;  1ITX A;  4DRJ A;  4QT3 A;  4W9Q A;  1H0I A;  3ARO A;  1E44 A;  2DG9 A;  1LG2 A;  4WKF A;  3WD4 A;  1FKI A;  1BL4 A;  1D6O A;  4DRP A;  4MGV A;  4C02 B;  4DRH A;  3O5R A;  5GPG A;  1F40 A;  2YBT A;  3FAP A;  1LL4 A;  1EIB A;  2XPB A;  2DT1 A;  4IPX A;  3PRD A;  2WLY A;  4DIP A;  4ODL A;  2B5U B;  2LGO A;  2XPA A;  4R0X A;  3TDB A;  4TW6 A;  3JXV A;  2G41 A;  1KFW A;  3ARS A;  3B8S A;  2F23 A;  3KZ7 A;  4DZ2 A;  1CTN A;  1J4H A;  1TFV A;  2PN0 A;  4DRK A;  3QOK A;  4NSB A;  3ALG A;  1LG1 A;  1FFR A;  4LAW A;  3WL0 A;  2ZQV A;  3UI6 A;  3FXY A;  3WQW A;  1ZBC A;  4P8U A;  1HKJ A; 
#chains in the Genus database with same CATH homology
 4TNS A;  2VCD A;  1IX5 A;  2XP8 A;  2G8Z A;  1Y0O A;  1N1A A;  1ZBV A;  1QPL A;  3ARU A;  4ZS6 A;  1H0G A;  1PIN A;  3I6C A;  3WQV A;  3CZ8 A;  3PR9 A;  4MPK A;  2F21 A;  4DWS A;  5JH8 A;  1J4I A;  3O5O A;  4QZV B;  1EHN A;  4DT4 A;  2XP4 A;  4IT4 A;  4WJX A;  2KE0 A;  4ODN A;  3JYJ A;  1NH6 A;  1ROU A;  2DSV A;  4W9O A;  1JVW A;  2B31 A;  2PI6 A;  3O5I A;  3PRA A;  4TW7 A;  2IUZ A;  3IKG A;  3O5E A;  1NWR A;  4P8W A;  3UQB A;  4ZPT R;  2MLY A;  1K9T A;  5HWB A;  2DT2 A;  5HW8 A;  2N87 A;  5DIU A;  1ZL1 A;  1HKI A;  4Z2H A;  2MF9 A;  3O5J A;  4WKA A;  3KAF A;  4J4O A;  4LAX A;  2A3E A;  2M08 A;  3O5K A;  1TCO C;  1ZBK A;  1ZK6 A;  2AOS A;  3WD0 A;  1NMV A;  5DIT A;  4MTV A;  3KAC A;  3CGM A;  5DO2 A;  2IF4 A;  2XP3 A;  5HTG A;  1T11 A;  1F8A B;  4PTM A;  3AS2 A;  3PA7 A;  1GUV A;  4WKH A;  2MLX A;  5HBF A;  3CHF A;  3WKZ A;  2FKE A;  4AY1 A;  1HJV A;  3BXW A;  2ZR6 A;  2KFW A;  4IT6 A;  5DIV A;  2DSZ A;  4FAP A;  1L1P A;  1M5Y A;  4DZ3 A;  1FKL A;  1W9V A;  2LJ4 A;  3RM4 A;  2FAP A;  2PV2 A;  1W1Y A;  1ZCN A;  2LPV A;  3TC5 A;  4DRO A;  3KAB A;  2M1I A;  4S3K A;  3RFW A;  3TCZ A;  3B9A A;  1FKD A;  2PV1 A;  3AS0 A;  4P8X A;  4IQ2 A;  2DG3 A;  1QPF A;  4TW8 A;  1NWT A;  1D7I A;  4P8V A;  3KAG A;  1FKH A;  4JFL A;  1XHG A;  4U84 A;  1HKK A;  2PPO A;  2A3B A;  3ARV A;  4W5U A;  3WD1 A;  4U86 A;  2M2A A;  1LL7 A;  1E9L A;  1OWQ A;  4LGX A;  3PRB A;  5DF0 A;  4ODO A;  2K8I A;  1D7J A;  1WNO A;  3NRK A;  2MPH A;  2JZV A;  5DEZ A;  2KI3 A;  3H9R B;  1E6P A;  1W1P A;  4MSP A;  1GPF A;  1W9P A;  2OLH A;  3ALF A;  1FKJ A;  4DWS C;  2XP9 A;  1FKR A;  1E15 A;  4FN2 A;  2VN1 A;  3VAW A;  2XP6 A;  2ZR5 A;  3O5P A;  4Z2L A;  3ARY A;  2F2D A;  3O5F A;  4MNL A;  2XP7 A;  2PPN A;  4ODQ A;  4DH0 A;  1BKF A;  1NWS A;  3ARX A;  4MNK A;  4TX0 A;  3AS1 A;  2OFN A;  1ZU8 A;  3ARW A;  3CHC A;  3WIJ A;  4DWS B;  4JFI A;  4JYS A;  1X6N A;  3O5G A;  1XRV A;  1EQ3 A;  3RGC A;  4XAK A;  4J4N A;  3B9E A;  3FY1 A;  3ARP A;  3UF8 A;  4LAY A;  1HXV A;  1O6I A;  3O5M A;  1U79 A;  3NTP A;  1Q1C A;  2LKN A;  1PBK A;  1Q6H A;  3KCE A;  2XP5 A;  1GOI A;  3CHE A;  4QT2 A;  4Z2K A;  1FKB A;  4S3J A;  2WK2 A;  2ESC A;  4R5E A;  2KO7 A;  2RUD A;  1E6R A;  2RQS A;  4BF8 A;  1FJD A;  2RUC A;  4W9P A;  5I98 A;  1W1V A;  1FKS A;  1OGB A;  3OOB A;  2O9O A;  5J6E A;  2WLZ A;  3ODK A;  1YW5 A;  1LL6 A;  2UZ5 A;  4JFK A;  1NWU A;  3KAD A;  1HKM A;  4NNR A;  1D2K A;  1R9H A;  1JNT A;  2A3C A;  4Q7N A;  1P5Q A;  4ODP A;  1FD9 A;  1OGG A;  1FKG A;  3UI4 A;  1W9U A;  3EY6 A;  3AS3 A;  3CHD A;  2DT0 A;  2RUR A;  3WH0 A;  2RSE A;  1NMW A;  3IHZ A;  3RME A;  3WL1 A;  3WD2 A;  3B7X A;  2DSW A;  3WD3 A;  4GGQ A;  1W1T A;  2MLZ A;  3G6M A;  2DT3 A;  3KAI A;  4MAV A;  1LQ0 A;  1JNS A;  4DWS D;  4Q22 A;  5HUA A;  3RM9 A;  5D75 A;  1EDQ A;  1KT0 A;  4JFJ A;  2AWG A;  4Z2J A;  5HT1 A;  3B9D A;  4Z2G A;  1E6Z A;  2KR7 A;  1FAP A;  2ITK A;  1FKK A;  4O2T A;  2ZR4 A;  3W4R A;  2Q5A A;  3UQI A;  2Y78 A;  5HWC A;  3KAH A;  4L3N A;  4ZPV R;  4G50 A;  4ITZ A;  1X6L A;  3CGN A;  3IKD A;  2MNT A;  3RM8 A;  4Z2I A;  4WK9 A;  2FDM A;  1SR0 A;  5HKG A;  2PBC A;  4ML4 A;  1JND A;  4DRM A;  4ODM A;  1ROT A;  1SYT A;  2PV3 A;  5GQB A;  3AQU A;  1FKT A;  5HW7 A;  4ODR A;  4MNJ A;  1KT1 A;  4N19 A;  3ARZ A;  4KR0 B;  1J6Y A;  2O92 A;  2DSU A;  2ZQT A;  2ZQS A;  1Q6I A;  1RD6 A;  4L72 B;  2YBU A;  4ZPW R;  1UR8 A;  2ZQU A;  4DRI A;  3G6L A;  4JFM A;  1UR9 A;  4WIW A;  4HBO A;  1WB0 A;  1B6C A;  1EYM A;  3LUO A;  5BXJ A;  4IQC A;  2DPE A;  1NSG A;  1QZ2 A;  3O5L A;  4U85 A;  1HJX A;  3JYM A;  2QF8 A;  4GIV A;  3IK8 A;  3O5D A;  1HJW A;  5HW6 A;  3ARQ A;  3UI5 A;  2KGJ A;  1C9H A;  4ODK A;  1VF8 A;  3NI6 A;  4MNM A;  2F4E A;  4NZC A;  4HBE A;  1YAT A;  5GPR A;  2DG4 A;  2RUQ A;  3GPK A;  2D9F A;  4URI A;  2L2S A;  4HAR A;  1D7H A;  4KQZ A;  4QIB A;  1ZBW A;  3MDY B;  2PPP A;  1W26 A;  1LJY A;  4TYO A;  1Q6U A;  4G2P A;  1E6N A;  1FFQ A;  3ART A;  1FKF A;  1J4R A;  3CH9 A;  5B8I C;  3O5Q A;  3ARR A;  3OA5 A;  1JNE A;  3UQA A;  2WM0 A;  1ZB5 A;  4LAV A;  4DRN A;  4DRQ A;  2A3A A;  1A7X A;  1WAW A;  1ITX A;  4DRJ A;  4QT3 A;  4W9Q A;  1H0I A;  3ARO A;  2DG9 A;  1LG2 A;  4WKF A;  3WD4 A;  1FKI A;  1BL4 A;  1D6O A;  4DRP A;  4MGV A;  4C02 B;  4DRH A;  3O5R A;  5GPG A;  1F40 A;  2YBT A;  3FAP A;  1LL4 A;  1EIB A;  2XPB A;  2DT1 A;  4IPX A;  3PRD A;  2WLY A;  4DIP A;  4ODL A;  2LGO A;  2XPA A;  4R0X A;  3TDB A;  4TW6 A;  3JXV A;  2G41 A;  1KFW A;  3ARS A;  3B8S A;  3KZ7 A;  4DZ2 A;  1CTN A;  1J4H A;  1TFV A;  4DRK A;  3QOK A;  4NSB A;  3ALG A;  1LG1 A;  1FFR A;  4LAW A;  3WL0 A;  2ZQV A;  3UI6 A;  3FXY A;  3WQW A;  1ZBC A;  4P8U A;  1HKJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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