4YFXA

Escherichia coli rna polymerase in complex with myxopyronin b
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
229
structure length
229
Chain Sequence
EFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
pubmed doi rcsb
molecule tags Transcription/transcription inhibitor
source organism Escherichia coli o139:h28 (strain e24377a / etec)
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 40
structure length 229
sequence length 229
chains with identical sequence B, G, H
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01000 RNA_pol_A_bac RNA polymerase Rpb3/RpoA insert domain
A PF01193 RNA_pol_L RNA polymerase Rpb3/Rpb11 dimerisation domain
A PF03118 RNA_pol_A_CTD Bacterial RNA polymerase, alpha chain C terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.120.12 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 DNA-directed RNA polymerase, insert domain 4yfxA02
3.30.1360.10 Alpha Beta 2-Layer Sandwich Gyrase A; domain 2 RNA polymerase, RBP11-like subunit 4yfxA01
1I6VA 1TWAC 2NVXC 4C2MC 3S1NC 5C4JC 5C4XK 4A93C 3GTMK 2NVQC 3GTKC 4BBRC 3S1MK 3GTPC 3HOZK 2YU9C 4A3LK 4C3IK 3S16K 1Y1VC 2JA5K 2NVXK 4C2MK 4C3HC 5IYCC 2JA6K 3S1NK 3I4NK 4A93K 3FKIC 2E2HK 1HQMA 3M3YC 4A3EK 2YU9K 4Y52C 4A3CC 3HOYC 4MQ9A 3K7AC 3RZOK 3HOWC 3GTLC 2NVYC 2JA7C 3HKZL 2R92C 3M3YK 4Y52K 4MEYA 1R9TK 5C3EC 4A3DC 3S16C 3H3VL 3HOWK 3WODA 3GTJC 3GTLK 5FJ8K 3S2DC 3S17K 3S1RK 2R93K 1WCMC 5IP9K 3M4OC 4A3MC 1I50K 4AYBL 2R92K 4OIRA 3S14C 3H3VD 4JK1A 1Y1WC 2O5JA 4A3BC 2E2IC 1WCMK 3S1QC 5IP7K 3S17C 2R93C 4AYBD 1BDFA 1ZYRA 5D4DA 4A3FC 2E2JC 1TWCC 3HOUC 4A3BK 4YFKA 4OINA 2WB1L 1TWAK 3EQLA 3DXJA 1SMYA 4KN4A 4LJZA 4OIPA 5C44C 3RZDC 5C4JK 2NVQK 4BBRK 3GTKK 4BXXC 3GTPK 1TWCK 3S15C 3HOUK 2WAQL 4BY7C 1Y1VK 4Q5SA 2VUMC 5IYCK 2JA8C 4C3HK 3RZDK 3FKIK 4X6AC 2BE5A 2CW0A 4A3CK 5M5WK 4A3GC 3HOYK 4OIOA 4XLPA 3K7AK 1K83C 2WAQD 4ZH4A 2VUMK 4QJVA 2NVYK 2JA7K 2A69A 1TWFC 3HOXC 5FLMC 4C3JC 3HKZD 5TMFA 5C3EK 4A3DK 4A3GK 4A3KC 5IYBC 3GTOC 1K83K 3GTJK 1TWHC 3S2DK 4GZYA 5M5YK 4YFXA 1TWFK 3M4OK 4A3MK 1TWGC 4G7HA 2B63C 3S14K 2A6HA 1Y1WK 4BY1C 4KMUA 2PA8L 2PPBA 4YG2A 2E2IK 3S1QK 5TMCA 3CQZC 4OIQA 4A3FK 2E2JK 2B63K 3GTQC 2R7ZC 4QIWL 4BY1K 2WB1D 2PA8D 1XPPA 5C44K 3CQZK 2PMZL 4BXXK 5C4XC 5IYDC 5M3MK 3S15K 4YFNA 4A3IC 4LK0A 1SFOC 3S1MC 4BY7K 1IW7A 3H0GC 1YNJA 4QIWD 4C3IC 4QJVB 2JA8K 1I3QC 4LLGA 4X6AK 2JA5C 2JA6C 4G7OA 4KN7A 2PMZD 4MEXA 3I4NC 2E2HC 5IYDK 3PO2C 4A3IK 1SFOK 5M3FK 4BBSC 2A68A 4A3EC 4G7ZA 3H0GK 4LK1A 1I3QK 1YNNA 3RZOC 2NVTC 3HOXK 5FLMK 4C3JK 3PO2K 3I4MC 4A3KK 5IYBK 3GTOK 3HOVC 4BBSK 4XSZA 1TWHK 1R9TC 1I6HC 2Y0SL 1TWGK 2NVTK 3S1RC 5IP9C 3S2HC 3I4MK 1I50C 3PO3C 3HOVK 4XSXA 1I6HK 4XLNA 4A3JC 3GTGC 5M5XK 2Y0SD 4Y7NC 3S2HK 5IP7C 3PO3K 3GTMC 3GTQK 2R7ZK 2A6EA 3HOZC 4A3JK 4A3LC 4Q4ZA 3GTGK 2O5IA 4Y7NK 4NOIA
chains in the Genus database with same CATH superfamily
1TWAC 5C4JC 4A93C 1G51A 4BBRC 3S1MK 4P5BA 1XZQA 4C3IK 4KAWX 1Y1VC 2JA5K 1Y1WA 4A93K 2E2HK 2ZUFA 1O26A 4A3EK 1X31C 1F7UA 2B63A 1UV7A 4MQ9A 3L4JA 2NVYC 2R92C 3IPJA 5C3EC 3H3VL 1BJTA 3QX3A 1I50K 2R92K 5JVGS 3H3VD 1EI6A 1F93A 1SFOA 4G0UA 3H0GA 1INNA 1F9NA 3S17C 2R93C 1AB4A 5IP7K 4GTEA 1I3QA 1ZYRA 1TWFA 1IBAA 5IOQA 4OINA 3GTOA 3EQLA 1TWHA 3DXJA 4KN4A 4OIPA 3GIRA 3S17K 2R93K 3GTKK 1TWGA 3GTPK 1YCLA 4KATA 1DD5A 1YX2A 4Q5SA 2VUMC 5IYCK 2JA8C 4AH6A 2CFAA 4A3CK 3K7AK 3GTQA 5TJ3A 2R7ZA 3AD9C 2VUMK 4O2DA 4C3JC 3HKZD 4GTBA 5M5YK 5L46A 4A3MK 2B63C 3L4KA 2A6HA 1WOPA 1Y1WK 2GAHC 2YU9A 4BY1C 3FOFA 3S1QK 4YG2A 3TFIA 4OIQA 2B63K 5DM6S 4BY1K 2WB1D 1R9TA 4P9SA 1XPPA 2L3UA 2PMZL 5C4XC 5IYDC 1SFOC 1L0WA 3H0GC 2RH6A 1I3QC 4X6AK 1XXBA 2EBBA 4KM8A 5IYDK 4KN7A 2PMZD 4WF9S 4M1XA 4G0WA 1WCMA 1SFOK 3H0GK 1I3QK 1O2AA 4WFNS 2NVTC 3HOXK 2ZFZA 1TWAA 3AH5A 3FHZA 3GTOK 3HOVC 1TWHK 1VH2A 1WQGA 2Y0SL 1TWGK 2NVTK 1Y1VA 5E68A 3G4CA 3HOVK 2GAGC 2W7VA 3A8KA 2Y0SD 4Y7NC 2FQTA 1BGWA 2NVYA 4J3NA 3GTQK 2R7ZK 2A6EA 3HOZC 4Y7NK 2NVXC 4C2MC 3HOZK 2YU9C 4WCES 4GFQA 4C2MK 2NVXK 1O28A 3I4NK 3FKIC 1JVIA 2R93A 3M3YC 2YU9K 3HOYC 1IQ0A 3HOWC 4IOCS 1DCHA 2JA7C 3M3YK 2GSNA 1R9TK 5DM7S 4A3DC 3HOWK 1PJ5A 2GSOA 4WJ4A 2ZJPS 3S2DC 3S1RK 3T01A 2VUMA 1WCMC 5IP9K 3M4OC 3OEPA 4JK1A 1WCMK 1J6WA 1J6XA 3Q3QA 4A3FC 1TWCC 4YFKA 1TWAK 5C4JK 4LJZA 1KQ4A 5HL7S 3TFHA 4BBRK 4BXXC 4IOAS 1TWCK 2WAQL 4BY7C 1Y1VK 1O27A 3TTGA 1PJ6A 4A3GC 5HL8A 2WAQD 2NVYK 3GTGA 2A69A 1ZXOA 5FLMC 5C3EK 4A3GK 5IYBC 3OPFA 4GZYA 2KWAA 3T02A 1XZQB 1DCPA 1BS2A 4PABA 2XCQA 1V5VA 4PAAA 3A8IA 3LPXA 3GTLA 2KXYA 2ZUEA 2JA8K 2JA6C 3OREA 4BBSC 4G7ZA 1YNNA 3RZOC 4KB4A 4LQYA 4C3JK 2NVXA 4IO9S 4BBSK 4XSZA 2V6TA 1B4BA 4G0VA 3PO3C 3FKIA 3LAPA 3GTGC 1ZQ1C 2CFAB 4C45A 3PO3K 2JA7A 1WQFA 3GTGK 4A3LC 4Q4ZA 2O5IA 4BLBA 3S16C 1I6VA 3CAGA 3N0CA 4KARA 4BLAA 5C4XK 5M5XK 2NVQC 3AQPA 3MMLB 3N0BA 4KMDA 4WFBS 3V4GA 4A3LK 1JQWA 3S16K 4C3HC 1EFWA 5JFEA 3PIPS 2JH3A 1TWCA 3GTLC 2KPUA 1WORA 1B4AA 1XZPA 4MEYA 3GTJC 3GTLK 4GTDA 4AYBL 3AD7C 3TFJA 4OIRA 3S14C 2FQOA 2O5JA 4A3BC 2E2IC 2GSUA 3AQOA 4AYBD 2E2JC 3HOUC 3BUEA 4A3BK 3GSIA 5JVOA 5C44C 3VA7A 3S15C 3HXAA 3HOUK 1J98A 2ZJQS 3FKIK 2BE5A 2CW0A 1XXAA 3HOYK 4XLPA 1USOA 1K83C 4QJVA 2JA7K 4DDQA 1O29A 5TMFA 1FEUA 1VLOA 4A3DK 4A3KC 1K83K 3GTMA 3S2DK 4YFXA 3M4OK 1EH1A 2JA6A 1HI9A 2D6FC 2PPBA 5TMCA 4A3FK 4BKWA 4QIWL 1IL2A 4GTCA 5EGHA 3LAJA 4BXXK 5M3MK 4YFNA 4A3IC 4LK0A 3S1MC 4BY7K 4QIWD 4QJVB 4C3IC 4WJ3M 4LLGA 3JSTA 2JA5C 1J6VA 2E2HC 3PO2C 3GEIA 4A3IK 5M3FK 3NUHA 1EQRA 4A3EC 4LK1A 1O2FB 4RMFA 4KASA 5FLMK 4GTAA 2L5NA 3PO2K 3I4MC 5IYBK 4LOWA 3I4MK 1I50C 4ILDA 1VJEA 4XLNA 4WILA 5IP7C 3GTMC 1DCOA 4NOIA 3GTJA 3S1NC 2V6SA 3DLLS 2P5MA 3GTMK 3GTKC 3GEEA 3GTPC 3BP8C 5HQHA 1USMA 1XXCA 2JA6K 1F7VA 2V6UA 5IYCC 3S1NK 3S0XA 2E2IA 1HQMA 1O2BA 4Y52C 4A3CC 3K7AC 3RZOK 5IOTA 1WIHA 3HKZL 3PIOS 4Y52K 3CQZA 4GTLA 3WODA 5FJ8K 3N3YA 1WOOA 4KMAA 4A3MC 1GE9A 4FZBA 1VGXA 1JOEA 1Y1WC 3T00A 1K83A 5JVHS 4XCHA 3S1QC 1BDFA 5D4DA 5CJ9A 1WSRA 3SZYA 2WB1L 3ADAC 1SMYA 2PHCB 3RZDC 3ERED 2P8TA 2NVQK 4KM9A 3GEHA 4LR2A 4C3HK 3FOEA 3RZDK 4X6AC 4KB2A 5M5WK 4OIOA 3CF5S 4ZH4A 4GTFA 5IOSA 1TWFC 1O24A 3GDZA 3AD8C 3HOXC 1EK8A 3GTOC 3GTJK 1TWHC 2KQ1A 1TWFK 1TWGC 4G7HA 4KC6A 1WQHA 2JA5A 3S14K 2RGRA 2E2HA 2XCOA 2PA8L 4KMUA 2E2IK 1WOSA 3CQZC 2E2JK 3GTQC 2R7ZC 2PA8D 5C44K 4P5AA 1C0AA 1XZPB 3CQZK 3S15K 1I50A 2R92A 3LYWA 1ZVUA 1IW7A 1YNJA 3G4AA 4GT9A 4FM9A 4G7OA 4MEXA 3I4NC 4WFAS 2A68A 4KDDA 5CHPA 1IS1A 1PJ7A 4A3KK 3GTKA 1WSVA 1RU0A 4KMHA 3GTPA 1R9TC 1I6HC 1O25A 5IORA 3A8JA 3S1RC 5IP9C 3S2HC 2XCRB 4XSXA 1I6HK 4A3JC 1ZBSA 1IE0A 2ZJRS 1VRQC 1ISEA 3S2HK 5EGEA 2Y3PA 3BP3A 4U67S 3SZZA 4A3JK
chains in the Genus database with same CATH topology
1I6VA 1TWAC 2NVXC 4C2MC 3S1NC 5C4JC 5C4XK 4A93C 3GTMK 2NVQC 3GTKC 4BBRC 3S1MK 3GTPC 3HOZK 2YU9C 4A3LK 4C3IK 3S16K 1Y1VC 2JA5K 2NVXK 4C2MK 4C3HC 5IYCC 2JA6K 3S1NK 3I4NK 4A93K 3FKIC 2E2HK 1HQMA 3M3YC 4A3EK 2YU9K 4Y52C 4A3CC 3HOYC 4MQ9A 3K7AC 3RZOK 3HOWC 3GTLC 2NVYC 2JA7C 3HKZL 2R92C 3M3YK 4Y52K 4MEYA 1R9TK 5C3EC 4A3DC 3S16C 3H3VL 3HOWK 3WODA 3GTJC 3GTLK 5FJ8K 3S2DC 3S17K 3S1RK 2R93K 1WCMC 5IP9K 3M4OC 4A3MC 1I50K 4AYBL 2R92K 4OIRA 3S14C 3H3VD 4JK1A 1Y1WC 2O5JA 4A3BC 2E2IC 1WCMK 3S1QC 5IP7K 3S17C 2R93C 4AYBD 1BDFA 1ZYRA 5D4DA 4A3FC 2E2JC 1TWCC 3HOUC 4A3BK 4YFKA 4OINA 2WB1L 1TWAK 3EQLA 3DXJA 1SMYA 4KN4A 4LJZA 4OIPA 5C44C 3RZDC 5C4JK 2NVQK 4BBRK 3GTKK 4BXXC 3GTPK 1TWCK 3S15C 3HOUK 2WAQL 4BY7C 1Y1VK 4Q5SA 2VUMC 5IYCK 2JA8C 4C3HK 3RZDK 3FKIK 4X6AC 2BE5A 2CW0A 4A3CK 5M5WK 4A3GC 3HOYK 4OIOA 4XLPA 3K7AK 1K83C 2WAQD 4ZH4A 2VUMK 4QJVA 2NVYK 2JA7K 2A69A 1TWFC 3HOXC 5FLMC 4C3JC 3HKZD 5TMFA 5C3EK 4A3DK 4A3GK 4A3KC 5IYBC 3GTOC 1K83K 3GTJK 1TWHC 3S2DK 4GZYA 5M5YK 4YFXA 1TWFK 3M4OK 4A3MK 1TWGC 4G7HA 2B63C 3S14K 2A6HA 1Y1WK 4BY1C 4KMUA 2PA8L 2PPBA 4YG2A 2E2IK 3S1QK 5TMCA 3CQZC 4OIQA 4A3FK 2E2JK 2B63K 3GTQC 2R7ZC 4QIWL 4BY1K 2WB1D 2PA8D 1XPPA 5C44K 3CQZK 2PMZL 4BXXK 5C4XC 5IYDC 5M3MK 3S15K 4YFNA 4A3IC 4LK0A 1SFOC 3S1MC 4BY7K 1IW7A 3H0GC 1YNJA 4QIWD 4C3IC 4QJVB 2JA8K 1I3QC 4LLGA 4X6AK 2JA5C 2JA6C 4G7OA 4KN7A 2PMZD 4MEXA 3I4NC 2E2HC 5IYDK 3PO2C 4A3IK 1SFOK 5M3FK 4BBSC 2A68A 4A3EC 4G7ZA 3H0GK 4LK1A 1I3QK 1YNNA 3RZOC 2NVTC 3HOXK 5FLMK 4C3JK 3PO2K 3I4MC 4A3KK 5IYBK 3GTOK 3HOVC 4BBSK 4XSZA 1TWHK 1R9TC 1I6HC 2Y0SL 1TWGK 2NVTK 3S1RC 5IP9C 3S2HC 3I4MK 1I50C 3PO3C 3HOVK 4XSXA 1I6HK 4XLNA 4A3JC 3GTGC 5M5XK 2Y0SD 4Y7NC 3S2HK 5IP7C 3PO3K 3GTMC 3GTQK 2R7ZK 2A6EA 3HOZC 4A3JK 4A3LC 4Q4ZA 3GTGK 2O5IA 4Y7NK 4NOIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I6V A;  1TWA C;  2NVX C;  4C2M C;  3S1N C;  5C4J C;  5C4X K;  4A93 C;  3GTM K;  2NVQ C;  3GTK C;  4BBR C;  3S1M K;  3GTP C;  3HOZ K;  2YU9 C;  4A3L K;  4C3I K;  3S16 K;  1Y1V C;  2JA5 K;  2NVX K;  4C2M K;  4C3H C;  5IYC C;  2JA6 K;  3S1N K;  3I4N K;  4A93 K;  3FKI C;  2E2H K;  1HQM A;  3M3Y C;  4A3E K;  2YU9 K;  4Y52 C;  4A3C C;  3HOY C;  4MQ9 A;  3K7A C;  3RZO K;  3HOW C;  3GTL C;  2NVY C;  2JA7 C;  3HKZ L;  2R92 C;  3M3Y K;  4Y52 K;  4MEY A;  1R9T K;  5C3E C;  4A3D C;  3S16 C;  3H3V L;  3HOW K;  3WOD A;  3GTJ C;  3GTL K;  5FJ8 K;  3S2D C;  3S17 K;  3S1R K;  2R93 K;  1WCM C;  5IP9 K;  3M4O C;  4A3M C;  1I50 K;  4AYB L;  2R92 K;  4OIR A;  3S14 C;  3H3V D;  4JK1 A;  1Y1W C;  2O5J A;  4A3B C;  2E2I C;  1WCM K;  3S1Q C;  5IP7 K;  3S17 C;  2R93 C;  4AYB D;  1BDF A;  1ZYR A;  5D4D A;  4A3F C;  2E2J C;  1TWC C;  3HOU C;  4A3B K;  4YFK A;  4OIN A;  2WB1 L;  1TWA K;  3EQL A;  3DXJ A;  1SMY A;  4KN4 A;  4LJZ A;  4OIP A;  5C44 C;  3RZD C;  5C4J K;  2NVQ K;  4BBR K;  3GTK K;  4BXX C;  3GTP K;  1TWC K;  3S15 C;  3HOU K;  2WAQ L;  4BY7 C;  1Y1V K;  4Q5S A;  2VUM C;  5IYC K;  2JA8 C;  4C3H K;  3RZD K;  3FKI K;  4X6A C;  2BE5 A;  2CW0 A;  4A3C K;  5M5W K;  4A3G C;  3HOY K;  4OIO A;  4XLP A;  3K7A K;  1K83 C;  2WAQ D;  4ZH4 A;  2VUM K;  4QJV A;  2NVY K;  2JA7 K;  2A69 A;  1TWF C;  3HOX C;  5FLM C;  4C3J C;  3HKZ D;  5TMF A;  5C3E K;  4A3D K;  4A3G K;  4A3K C;  5IYB C;  3GTO C;  1K83 K;  3GTJ K;  1TWH C;  3S2D K;  4GZY A;  5M5Y K;  4YFX A;  1TWF K;  3M4O K;  4A3M K;  1TWG C;  4G7H A;  2B63 C;  3S14 K;  2A6H A;  1Y1W K;  4BY1 C;  4KMU A;  2PA8 L;  2PPB A;  4YG2 A;  2E2I K;  3S1Q K;  5TMC A;  3CQZ C;  4OIQ A;  4A3F K;  2E2J K;  2B63 K;  3GTQ C;  2R7Z C;  4QIW L;  4BY1 K;  2WB1 D;  2PA8 D;  1XPP A;  5C44 K;  3CQZ K;  2PMZ L;  4BXX K;  5C4X C;  5IYD C;  5M3M K;  3S15 K;  4YFN A;  4A3I C;  4LK0 A;  1SFO C;  3S1M C;  4BY7 K;  1IW7 A;  3H0G C;  1YNJ A;  4QIW D;  4C3I C;  4QJV B;  2JA8 K;  1I3Q C;  4LLG A;  4X6A K;  2JA5 C;  2JA6 C;  4G7O A;  4KN7 A;  2PMZ D;  4MEX A;  3I4N C;  2E2H C;  5IYD K;  3PO2 C;  4A3I K;  1SFO K;  5M3F K;  4BBS C;  2A68 A;  4A3E C;  4G7Z A;  3H0G K;  4LK1 A;  1I3Q K;  1YNN A;  3RZO C;  2NVT C;  3HOX K;  5FLM K;  4C3J K;  3PO2 K;  3I4M C;  4A3K K;  5IYB K;  3GTO K;  3HOV C;  4BBS K;  4XSZ A;  1TWH K;  1R9T C;  1I6H C;  2Y0S L;  1TWG K;  2NVT K;  3S1R C;  5IP9 C;  3S2H C;  3I4M K;  1I50 C;  3PO3 C;  3HOV K;  4XSX A;  1I6H K;  4XLN A;  4A3J C;  3GTG C;  5M5X K;  2Y0S D;  4Y7N C;  3S2H K;  5IP7 C;  3PO3 K;  3GTM C;  3GTQ K;  2R7Z K;  2A6E A;  3HOZ C;  4A3J K;  4A3L C;  4Q4Z A;  3GTG K;  2O5I A;  4Y7N K;  4NOI A; 
#chains in the Genus database with same CATH topology
 1TWA C;  5C4J C;  4A93 C;  1G51 A;  4BBR C;  3S1M K;  4P5B A;  1XZQ A;  4C3I K;  4KAW X;  1Y1V C;  2JA5 K;  1Y1W A;  4A93 K;  2E2H K;  2ZUF A;  1O26 A;  4A3E K;  1X31 C;  1F7U A;  2B63 A;  1UV7 A;  4MQ9 A;  3L4J A;  2NVY C;  2R92 C;  3IPJ A;  5C3E C;  3H3V L;  1BJT A;  3QX3 A;  1I50 K;  2R92 K;  5JVG S;  3H3V D;  1EI6 A;  1F93 A;  1SFO A;  4G0U A;  3H0G A;  1INN A;  1F9N A;  3S17 C;  2R93 C;  1AB4 A;  5IP7 K;  4GTE A;  1I3Q A;  1ZYR A;  1TWF A;  1IBA A;  5IOQ A;  4OIN A;  3GTO A;  3EQL A;  1TWH A;  3DXJ A;  4KN4 A;  4OIP A;  3GIR A;  3S17 K;  2R93 K;  3GTK K;  1TWG A;  3GTP K;  1YCL A;  4KAT A;  1DD5 A;  1YX2 A;  4Q5S A;  2VUM C;  5IYC K;  2JA8 C;  4AH6 A;  2CFA A;  4A3C K;  3K7A K;  3GTQ A;  5TJ3 A;  2R7Z A;  3AD9 C;  2VUM K;  4O2D A;  4C3J C;  3HKZ D;  4GTB A;  5M5Y K;  5L46 A;  4A3M K;  2B63 C;  3L4K A;  2A6H A;  1WOP A;  1Y1W K;  2GAH C;  2YU9 A;  4BY1 C;  3FOF A;  3S1Q K;  4YG2 A;  3TFI A;  4OIQ A;  2B63 K;  5DM6 S;  4BY1 K;  2WB1 D;  1R9T A;  4P9S A;  1XPP A;  2L3U A;  2PMZ L;  5C4X C;  5IYD C;  1SFO C;  1L0W A;  3H0G C;  2RH6 A;  1I3Q C;  4X6A K;  1XXB A;  2EBB A;  4KM8 A;  5IYD K;  4KN7 A;  2PMZ D;  4WF9 S;  4M1X A;  4G0W A;  1WCM A;  1SFO K;  3H0G K;  1I3Q K;  1O2A A;  4WFN S;  2NVT C;  3HOX K;  2ZFZ A;  1TWA A;  3AH5 A;  3FHZ A;  3GTO K;  3HOV C;  1TWH K;  1VH2 A;  1WQG A;  2Y0S L;  1TWG K;  2NVT K;  1Y1V A;  5E68 A;  3G4C A;  3HOV K;  2GAG C;  2W7V A;  3A8K A;  2Y0S D;  4Y7N C;  2FQT A;  1BGW A;  2NVY A;  4J3N A;  3GTQ K;  2R7Z K;  2A6E A;  3HOZ C;  4Y7N K;  2NVX C;  4C2M C;  3HOZ K;  2YU9 C;  4WCE S;  4GFQ A;  4C2M K;  2NVX K;  1O28 A;  3I4N K;  3FKI C;  1JVI A;  2R93 A;  3M3Y C;  2YU9 K;  3HOY C;  1IQ0 A;  3HOW C;  4IOC S;  1DCH A;  2JA7 C;  3M3Y K;  2GSN A;  1R9T K;  5DM7 S;  4A3D C;  3HOW K;  1PJ5 A;  2GSO A;  4WJ4 A;  2ZJP S;  3S2D C;  3S1R K;  3T01 A;  2VUM A;  1WCM C;  5IP9 K;  3M4O C;  3OEP A;  4JK1 A;  1WCM K;  1J6W A;  1J6X A;  3Q3Q A;  4A3F C;  1TWC C;  4YFK A;  1TWA K;  5C4J K;  4LJZ A;  1KQ4 A;  5HL7 S;  3TFH A;  4BBR K;  4BXX C;  4IOA S;  1TWC K;  2WAQ L;  4BY7 C;  1Y1V K;  1O27 A;  3TTG A;  1PJ6 A;  4A3G C;  5HL8 A;  2WAQ D;  2NVY K;  3GTG A;  2A69 A;  1ZXO A;  5FLM C;  5C3E K;  4A3G K;  5IYB C;  3OPF A;  4GZY A;  2KWA A;  3T02 A;  1XZQ B;  1DCP A;  1BS2 A;  4PAB A;  2XCQ A;  1V5V A;  4PAA A;  3A8I A;  3LPX A;  3GTL A;  2KXY A;  2ZUE A;  2JA8 K;  2JA6 C;  3ORE A;  4BBS C;  4G7Z A;  1YNN A;  3RZO C;  4KB4 A;  4LQY A;  4C3J K;  2NVX A;  4IO9 S;  4BBS K;  4XSZ A;  2V6T A;  1B4B A;  4G0V A;  3PO3 C;  3FKI A;  3LAP A;  3GTG C;  1ZQ1 C;  2CFA B;  4C45 A;  3PO3 K;  2JA7 A;  1WQF A;  3GTG K;  4A3L C;  4Q4Z A;  2O5I A;  4BLB A;  3S16 C;  1I6V A;  3CAG A;  3N0C A;  4KAR A;  4BLA A;  5C4X K;  5M5X K;  2NVQ C;  3AQP A;  3MML B;  3N0B A;  4KMD A;  4WFB S;  3V4G A;  4A3L K;  1JQW A;  3S16 K;  4C3H C;  1EFW A;  5JFE A;  3PIP S;  2JH3 A;  1TWC A;  3GTL C;  2KPU A;  1WOR A;  1B4A A;  1XZP A;  4MEY A;  3GTJ C;  3GTL K;  4GTD A;  4AYB L;  3AD7 C;  3TFJ A;  4OIR A;  3S14 C;  2FQO A;  2O5J A;  4A3B C;  2E2I C;  2GSU A;  3AQO A;  4AYB D;  2E2J C;  3HOU C;  3BUE A;  4A3B K;  3GSI A;  5JVO A;  5C44 C;  3VA7 A;  3S15 C;  3HXA A;  3HOU K;  1J98 A;  2ZJQ S;  3FKI K;  2BE5 A;  2CW0 A;  1XXA A;  3HOY K;  4XLP A;  1USO A;  1K83 C;  4QJV A;  2JA7 K;  4DDQ A;  1O29 A;  5TMF A;  1FEU A;  1VLO A;  4A3D K;  4A3K C;  1K83 K;  3GTM A;  3S2D K;  4YFX A;  3M4O K;  1EH1 A;  2JA6 A;  1HI9 A;  2D6F C;  2PPB A;  5TMC A;  4A3F K;  4BKW A;  4QIW L;  1IL2 A;  4GTC A;  5EGH A;  3LAJ A;  4BXX K;  5M3M K;  4YFN A;  4A3I C;  4LK0 A;  3S1M C;  4BY7 K;  4QIW D;  4QJV B;  4C3I C;  4WJ3 M;  4LLG A;  3JST A;  2JA5 C;  1J6V A;  2E2H C;  3PO2 C;  3GEI A;  4A3I K;  5M3F K;  3NUH A;  1EQR A;  4A3E C;  4LK1 A;  1O2F B;  4RMF A;  4KAS A;  5FLM K;  4GTA A;  2L5N A;  3PO2 K;  3I4M C;  5IYB K;  4LOW A;  3I4M K;  1I50 C;  4ILD A;  1VJE A;  4XLN A;  4WIL A;  5IP7 C;  3GTM C;  1DCO A;  4NOI A;  3GTJ A;  3S1N C;  2V6S A;  3DLL S;  2P5M A;  3GTM K;  3GTK C;  3GEE A;  3GTP C;  3BP8 C;  5HQH A;  1USM A;  1XXC A;  2JA6 K;  1F7V A;  2V6U A;  5IYC C;  3S1N K;  3S0X A;  2E2I A;  1HQM A;  1O2B A;  4Y52 C;  4A3C C;  3K7A C;  3RZO K;  5IOT A;  1WIH A;  3HKZ L;  3PIO S;  4Y52 K;  3CQZ A;  4GTL A;  3WOD A;  5FJ8 K;  3N3Y A;  1WOO A;  4KMA A;  4A3M C;  1GE9 A;  4FZB A;  1VGX A;  1JOE A;  1Y1W C;  3T00 A;  1K83 A;  5JVH S;  4XCH A;  3S1Q C;  1BDF A;  5D4D A;  5CJ9 A;  1WSR A;  3SZY A;  2WB1 L;  3ADA C;  1SMY A;  2PHC B;  3RZD C;  3ERE D;  2P8T A;  2NVQ K;  4KM9 A;  3GEH A;  4LR2 A;  4C3H K;  3FOE A;  3RZD K;  4X6A C;  4KB2 A;  5M5W K;  4OIO A;  3CF5 S;  4ZH4 A;  4GTF A;  5IOS A;  1TWF C;  1O24 A;  3GDZ A;  3AD8 C;  3HOX C;  1EK8 A;  3GTO C;  3GTJ K;  1TWH C;  2KQ1 A;  1TWF K;  1TWG C;  4G7H A;  4KC6 A;  1WQH A;  2JA5 A;  3S14 K;  2RGR A;  2E2H A;  2XCO A;  2PA8 L;  4KMU A;  2E2I K;  1WOS A;  3CQZ C;  2E2J K;  3GTQ C;  2R7Z C;  2PA8 D;  5C44 K;  4P5A A;  1C0A A;  1XZP B;  3CQZ K;  3S15 K;  1I50 A;  2R92 A;  3LYW A;  1ZVU A;  1IW7 A;  1YNJ A;  3G4A A;  4GT9 A;  4FM9 A;  4G7O A;  4MEX A;  3I4N C;  4WFA S;  2A68 A;  4KDD A;  5CHP A;  1IS1 A;  1PJ7 A;  4A3K K;  3GTK A;  1WSV A;  1RU0 A;  4KMH A;  3GTP A;  1R9T C;  1I6H C;  1O25 A;  5IOR A;  3A8J A;  3S1R C;  5IP9 C;  3S2H C;  2XCR B;  4XSX A;  1I6H K;  4A3J C;  1ZBS A;  1IE0 A;  2ZJR S;  1VRQ C;  1ISE A;  3S2H K;  5EGE A;  2Y3P A;  3BP3 A;  4U67 S;  3SZZ A;  4A3J K; 
#chains in the Genus database with same CATH homology
 1I6V A;  1TWA C;  2NVX C;  4C2M C;  3S1N C;  5C4J C;  5C4X K;  4A93 C;  3GTM K;  2NVQ C;  3GTK C;  4BBR C;  3S1M K;  3GTP C;  3HOZ K;  2YU9 C;  4A3L K;  4C3I K;  3S16 K;  1Y1V C;  2JA5 K;  2NVX K;  4C2M K;  4C3H C;  5IYC C;  2JA6 K;  3S1N K;  3I4N K;  4A93 K;  3FKI C;  2E2H K;  1HQM A;  3M3Y C;  4A3E K;  2YU9 K;  4Y52 C;  4A3C C;  3HOY C;  4MQ9 A;  3K7A C;  3RZO K;  3HOW C;  3GTL C;  2NVY C;  2JA7 C;  3HKZ L;  2R92 C;  3M3Y K;  4Y52 K;  4MEY A;  1R9T K;  5C3E C;  4A3D C;  3S16 C;  3H3V L;  3HOW K;  3WOD A;  3GTJ C;  3GTL K;  5FJ8 K;  3S2D C;  3S17 K;  3S1R K;  2R93 K;  1WCM C;  5IP9 K;  3M4O C;  4A3M C;  1I50 K;  4AYB L;  2R92 K;  4OIR A;  3S14 C;  3H3V D;  4JK1 A;  1Y1W C;  2O5J A;  4A3B C;  2E2I C;  1WCM K;  3S1Q C;  5IP7 K;  3S17 C;  2R93 C;  4AYB D;  1BDF A;  1ZYR A;  5D4D A;  4A3F C;  2E2J C;  1TWC C;  3HOU C;  4A3B K;  4YFK A;  4OIN A;  2WB1 L;  1TWA K;  3EQL A;  3DXJ A;  1SMY A;  4KN4 A;  4LJZ A;  4OIP A;  5C44 C;  3RZD C;  5C4J K;  2NVQ K;  4BBR K;  3GTK K;  4BXX C;  3GTP K;  1TWC K;  3S15 C;  3HOU K;  2WAQ L;  4BY7 C;  1Y1V K;  4Q5S A;  2VUM C;  5IYC K;  2JA8 C;  4C3H K;  3RZD K;  3FKI K;  4X6A C;  2BE5 A;  2CW0 A;  4A3C K;  5M5W K;  4A3G C;  3HOY K;  4OIO A;  4XLP A;  3K7A K;  1K83 C;  2WAQ D;  4ZH4 A;  2VUM K;  4QJV A;  2NVY K;  2JA7 K;  2A69 A;  1TWF C;  3HOX C;  5FLM C;  4C3J C;  3HKZ D;  5TMF A;  5C3E K;  4A3D K;  4A3G K;  4A3K C;  5IYB C;  3GTO C;  1K83 K;  3GTJ K;  1TWH C;  3S2D K;  4GZY A;  5M5Y K;  4YFX A;  1TWF K;  3M4O K;  4A3M K;  1TWG C;  4G7H A;  2B63 C;  3S14 K;  2A6H A;  1Y1W K;  4BY1 C;  4KMU A;  2PA8 L;  2PPB A;  4YG2 A;  2E2I K;  3S1Q K;  5TMC A;  3CQZ C;  4OIQ A;  4A3F K;  2E2J K;  2B63 K;  3GTQ C;  2R7Z C;  4QIW L;  4BY1 K;  2WB1 D;  2PA8 D;  1XPP A;  5C44 K;  3CQZ K;  2PMZ L;  4BXX K;  5C4X C;  5IYD C;  5M3M K;  3S15 K;  4YFN A;  4A3I C;  4LK0 A;  1SFO C;  3S1M C;  4BY7 K;  1IW7 A;  3H0G C;  1YNJ A;  4QIW D;  4C3I C;  4QJV B;  2JA8 K;  1I3Q C;  4LLG A;  4X6A K;  2JA5 C;  2JA6 C;  4G7O A;  4KN7 A;  2PMZ D;  4MEX A;  3I4N C;  2E2H C;  5IYD K;  3PO2 C;  4A3I K;  1SFO K;  5M3F K;  4BBS C;  2A68 A;  4A3E C;  4G7Z A;  3H0G K;  4LK1 A;  1I3Q K;  1YNN A;  3RZO C;  2NVT C;  3HOX K;  5FLM K;  4C3J K;  3PO2 K;  3I4M C;  4A3K K;  5IYB K;  3GTO K;  3HOV C;  4BBS K;  4XSZ A;  1TWH K;  1R9T C;  1I6H C;  2Y0S L;  1TWG K;  2NVT K;  3S1R C;  5IP9 C;  3S2H C;  3I4M K;  1I50 C;  3PO3 C;  3HOV K;  4XSX A;  1I6H K;  4XLN A;  4A3J C;  3GTG C;  5M5X K;  2Y0S D;  4Y7N C;  3S2H K;  5IP7 C;  3PO3 K;  3GTM C;  3GTQ K;  2R7Z K;  2A6E A;  3HOZ C;  4A3J K;  4A3L C;  4Q4Z A;  3GTG K;  2O5I A;  4Y7N K;  4NOI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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