1ZYIA

Solution structure of icln, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
116
structure length
116
Chain Sequence
QQQPETEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDLNAYPREHLYVMVNAKFGEESKESVAEEEDSDDDVEPIAEFRFVPSDKSALEAMFTAMCECQAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4
pubmed doi rcsb
molecule tags Translation
source organism Canis lupus familiaris
molecule keywords Methylosome subunit pICln
total genus 14
structure length 116
sequence length 116
ec nomenclature
pdb deposition date 2005-06-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.60 Mainly Beta Roll PH-domain like PH-domain like 1zyiA00
1ZYIA
chains in the Genus database with same CATH superfamily
4GMVA 2QKLA 2Y8GA 4A6FA 5HE1A 4H8SA 4PQ0A 1I2HA 1OQNA 5CLLB 5LG4B 5KCVA 3OHMB 5D3WA 1EVHA 5C5BB 2UZRA 1MIZB 2KUQA 2G35A 5HE2A 3P6AA 1XKEA 3IVFA 3GYOA 1OMWA 2KR0A 5D3VA 2KIEA 2OQBA 1MKEA 1V5PA 1KI1B 1U27A 2CY5A 1Y19B 1I7AA 2V76A 1WI1A 4QJ5B 4K2PA 2ZPYA 2D9WA 2LG1A 5GOWB 5LONB 1FHXA 2DX5A 2DHJA 2RLOA 3U8ZA 2RUKB 3MPXA 2UZSA 4BBKA 3B77A 3M1IB 2NMBA 1BAKA 1FGZA 2FJLA 4CHJA 4D6WA 1PLSA 4MY6A 4K2OA 1K5DB 3T06A 2Z0QA 3DCXA 3FVCA 4P7IA 4TKNA 4CHMA 5DHFB 3NWFA 2COCA 3AU5A 3HW2B 3QWMA 5I2SA 4HDOA 1OY2A 2Y7BA 1NTYA 1W1DA 2Z0PA 2K8EA 1BTKA 3OANA 3P7ZA 2P0DA 2L1CA 2Z13A 2DA0A 1Y5OA 5C79A 3N7CA 3LJUX 4HHVA 5CLQB 1MK7B 1UPRA 3HK0A 2CODA 2D4QA 1X05A 1U5FA 2QKMA 2ROVA 3ODWA 2ROZB 4GXBA 1UEFA 3PG7A 2NZ8B 2YT1A 4XWXA 4GPTB 2RNRB 1UNRA 5DI9B 4L6EA 1FHOA 2RSGA 5L81A 1ISNA 1FB8A 1ZSQA 2L2IA 1ZYIA 3CXBB 2YS5A 4HAWB 3WA0A 5M4YB 2Y8FA 2N23A 1V61A 3BJIA 1M7EA 3SUZA 3UZTA 1P5TA 1WG7A 2RRFA 4NSWA 3TO1A 2DYNA 4NY0A 1K5GB 2GJYA 3PVUA 2DKQA 3SNHA 4YL8A 3NWAA 2D10A 5C16A 3QBVB 2I5FA 2K49A 2GCLA 2MKRA 4A6KA 4EJNA 2H7DA 2FJUB 5J3TA 1XCGA 3AJ4A 4F7UP 2DHIA 4CSQA 4OSNA 1PFJA 2DKPA 1DYNA 2LOXA 3KY9A 1Q67A 1W1HA 2UVMA 2CY4A 2J0JA 4DIXA 1NI2A 4HAVB 3GYPA 1LB1A 2ELBA 2W2XD 2BCJA 2OTXA 3SO6A 1N3HA 3KSYA 4WJ7A 4HAXB 1AQCA 2IYBA 2HTHB 5J3QA 2D9VA 2K2JA 1P6SA 3U7DA 1ZC3B 2D9XA 3CIKA 4DBBA 4IAPA 2Z4DA 3ULBA 5J3YA 1H10A 3DXEA 3RCPA 5JHGA 4K17A 1V89A 1XODA 3MDBC 1X1FA 2H7EA 1UNPA 4GN1A 2Z14A 1WJ1A 3AU4A 1X1GA 1UNQA 1ZVRA 2X18A 4HATB 2I1JA 2DHKA 1EF1A 1WVHA 3NW8A 1ZC4B 4KHBA 4KHAA 4A6HA 1RJ2A 2YF0A 4HSIA 5JP4A 3HIEA 3O96A 5FI1A 3PVWA 5DH9B 4EKUA 4A6FB 4B6HA 1FGYA 2VRWB 5HE3A 5I2MA 3PZDA 2AL6A 4EMOA 5D3XA 5FI0A 1WJMA 1XR0B 3PEGA 1X11A 4DX90 2E2XA 5C5BA 3G9WA 2DX1A 1SHCA 1TXDA 4D0NB 1BTNA 2DYQA 4Y94A 2M14A 2RGNB 2Z59A 2COFA 1AWEA 2YSZA 1IRSA 4MT7A 2YT0A 4K81A 1GC6A 1QC6A 4HAZB 1MK9B 4QJ3B 3ODOA 2ADZA 2R0DA 2YRYA 2IFSA 3WYFB 1WGUA 1PMSA 2ZKMX 4WSFA 2KUPA 1WGQA 1GC7A 2P0HA 5HE0A 1MI1A 1Z87A 2HE7A 3KRXA 3ML4A 3TVVA 1U5EA 1J19A 2D2QA 1LW3A 3FM8C 2M38A 3KZ1A 4GZUA 2DTCA 3TCAA 3PVLA 3TW1A 2D11A 2PZ1A 1BWNA 1B55A 2KGXB 1U29A 2YVCA 1XX0A 2N0YA 2R2YA 2YT2A 4L1RA 3HQCA 3PSCA 4F7HA 1SGHA 4GMXB 5DIFB 2JP2A 1E5WA 3A98B 1U5DA 2P8VA 1V88A 3A58A 4HAUB 3DXDA 1NU2A 2EMSA 3A8PA 3D8DA 1MIXA 2GCJA 3U12A 1TJ6A 4TYZA 5KQ4A 1W1GA 2R09A 2K2UA 3A8QA 4YONA 2D9ZA 3SV1A 3KRWA 1DDWA 4DXAB 2I5CA 4GOUA 5DHAB 4WVFB 3F5RA 4IOYX 4GNKB 2D9YA 2LULA 2W2WA 4KAXB 5IRSA 3X23A 3ZVRA 1DROA 5C6RA 3NWDA 1FAOA 2Q13A 1NTVA 5D27A 3VIAA 2YS1A 2COAA 2CRFA 2LYDA 4C0AA 4HB0B 4QXAB 2GUMA 3D8EA 3ULCA 2YS3A 4A5KA 2EJ8A 2J59M 2LKOA 2VSZA 4QJ4B 2J0MA 2I1KA 1T77A 3QIJA 5LOPB 1QQGA 3TFMA 2J0KA 2DFKA 3FEHA 4IFSA 3VOQA 2MWNB 2K00A 2ELAA 3FSSA 1FHWA 2AEHA 1FOEA 3DXCA 2KCJA 5EFXA 3NSUA 4HAYB 4PNKA 5D3YA 4DX8A 2CAYA 1DDVA 1DDMA 5JHHA 1P3RA 1KZGA 1H4RA 3BINA 3PP2A 2DLWA 4HB4B 1MPHA 1EGXA 1KZ7A 3V5WA 1J0WA 5KQ1A 4ZRKA 1V5UA 4Z2MB 3ODXA 4KVGB 1UPQA 4OT1A 2EC1A 2KIGA 1MAIA 4HDQA 1U2BA 2Z0OA 5JLJB 2VKIA 4F7GA 2GS0A 3HSAA 2W2XC 1V5MA 1GG3A 2LOZA 2DN6A 2MDXA 2MFQA 3SYXA 2XQNM 1XD4A 1TQZA 2EMTA 1M7RA 4HB2B 4ZRJA 4Z2NA 1RRPB 4ZRIA 1DBHA 3D8FA 2P0FA 2RVBB 1ZM0A 3ZDTA 1EAZA 1X86A 4MK0A 4CYEA 4KHOA 3F0WA 4HB3B 1U5GA 4KHBB 2NBVA
chains in the Genus database with same CATH topology
4DIXA 4HSIA 2KR0A 3TW1A 5I2SA 4Z2MB 2KIEA 3HIEA 4IFSA 2Z4DA 3GYPA 4IOYX 4GNKB 2GCJA 3U12A 4OT1A 4PQ0A 3FSSA 2KIGA 3NWAA 4QJ3B 2K8EA 5I2MA 5IRSA 2R2YA 4Z2NA 2YT2A 4D6WA 4L1RA 2K49A 4QJ5B 2Z13A 3NWDA 2GCLA 5LG4B 2Z14A 2ZKMX 3OHMB 2FJUB 1ZYIA 4QXAB 2GUMA 5M4YB 3FVCA 4CSQA 3TVVA 2KUQA 4OSNA 3A58A 3NW8A 2Z59A 4KHOA 4QJ4B 4KHBA 3NWFA 4KHBB 4KHAA 2RRFA 4GOUA 3GYOA 3TO1A 2NBVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZYI A; 
#chains in the Genus database with same CATH topology
 4GMV A;  2QKL A;  2Y8G A;  4A6F A;  5HE1 A;  4H8S A;  4PQ0 A;  1I2H A;  1OQN A;  5CLL B;  5LG4 B;  5KCV A;  3OHM B;  5D3W A;  1EVH A;  5C5B B;  2UZR A;  1MIZ B;  2KUQ A;  2G35 A;  5HE2 A;  3P6A A;  1XKE A;  3IVF A;  3GYO A;  1OMW A;  2KR0 A;  5D3V A;  2KIE A;  2OQB A;  1MKE A;  1V5P A;  1KI1 B;  1U27 A;  2CY5 A;  1Y19 B;  1I7A A;  2V76 A;  1WI1 A;  4QJ5 B;  4K2P A;  2ZPY A;  2D9W A;  2LG1 A;  5GOW B;  5LON B;  1FHX A;  2DX5 A;  2DHJ A;  2RLO A;  3U8Z A;  2RUK B;  3MPX A;  2UZS A;  4BBK A;  3B77 A;  3M1I B;  2NMB A;  1BAK A;  1FGZ A;  2FJL A;  4CHJ A;  4D6W A;  1PLS A;  4MY6 A;  4K2O A;  1K5D B;  3T06 A;  2Z0Q A;  3DCX A;  3FVC A;  4P7I A;  4TKN A;  4CHM A;  5DHF B;  3NWF A;  2COC A;  3AU5 A;  3HW2 B;  3QWM A;  5I2S A;  4HDO A;  1OY2 A;  2Y7B A;  1NTY A;  1W1D A;  2Z0P A;  2K8E A;  1BTK A;  3OAN A;  3P7Z A;  2P0D A;  2L1C A;  2Z13 A;  2DA0 A;  1Y5O A;  5C79 A;  3N7C A;  3LJU X;  4HHV A;  5CLQ B;  1MK7 B;  1UPR A;  3HK0 A;  2COD A;  2D4Q A;  1X05 A;  1U5F A;  2QKM A;  2ROV A;  3ODW A;  2ROZ B;  4GXB A;  1UEF A;  3PG7 A;  2NZ8 B;  2YT1 A;  4XWX A;  4GPT B;  2RNR B;  1UNR A;  5DI9 B;  4L6E A;  1FHO A;  2RSG A;  5L81 A;  1ISN A;  1FB8 A;  1ZSQ A;  2L2I A;  1ZYI A;  3CXB B;  2YS5 A;  4HAW B;  3WA0 A;  5M4Y B;  2Y8F A;  2N23 A;  1V61 A;  3BJI A;  1M7E A;  3SUZ A;  3UZT A;  1P5T A;  1WG7 A;  2RRF A;  4NSW A;  3TO1 A;  2DYN A;  4NY0 A;  1K5G B;  2GJY A;  3PVU A;  2DKQ A;  3SNH A;  4YL8 A;  3NWA A;  2D10 A;  5C16 A;  3QBV B;  2I5F A;  2K49 A;  2GCL A;  2MKR A;  4A6K A;  4EJN A;  2H7D A;  2FJU B;  5J3T A;  1XCG A;  3AJ4 A;  4F7U P;  2DHI A;  4CSQ A;  4OSN A;  1PFJ A;  2DKP A;  1DYN A;  2LOX A;  3KY9 A;  1Q67 A;  1W1H A;  2UVM A;  2CY4 A;  2J0J A;  4DIX A;  1NI2 A;  4HAV B;  3GYP A;  1LB1 A;  2ELB A;  2W2X D;  2BCJ A;  2OTX A;  3SO6 A;  1N3H A;  3KSY A;  4WJ7 A;  4HAX B;  1AQC A;  2IYB A;  2HTH B;  5J3Q A;  2D9V A;  2K2J A;  1P6S A;  3U7D A;  1ZC3 B;  2D9X A;  3CIK A;  4DBB A;  4IAP A;  2Z4D A;  3ULB A;  5J3Y A;  1H10 A;  3DXE A;  3RCP A;  5JHG A;  4K17 A;  1V89 A;  1XOD A;  3MDB C;  1X1F A;  2H7E A;  1UNP A;  4GN1 A;  2Z14 A;  1WJ1 A;  3AU4 A;  1X1G A;  1UNQ A;  1ZVR A;  2X18 A;  4HAT B;  2I1J A;  2DHK A;  1EF1 A;  1WVH A;  3NW8 A;  1ZC4 B;  4KHB A;  4KHA A;  4A6H A;  1RJ2 A;  2YF0 A;  4HSI A;  5JP4 A;  3HIE A;  3O96 A;  5FI1 A;  3PVW A;  5DH9 B;  4EKU A;  4A6F B;  4B6H A;  1FGY A;  2VRW B;  5HE3 A;  5I2M A;  3PZD A;  2AL6 A;  4EMO A;  5D3X A;  5FI0 A;  1WJM A;  1XR0 B;  3PEG A;  1X11 A;  4DX9 0;  2E2X A;  5C5B A;  3G9W A;  2DX1 A;  1SHC A;  1TXD A;  4D0N B;  1BTN A;  2DYQ A;  4Y94 A;  2M14 A;  2RGN B;  2Z59 A;  2COF A;  1AWE A;  2YSZ A;  1IRS A;  4MT7 A;  2YT0 A;  4K81 A;  1GC6 A;  1QC6 A;  4HAZ B;  1MK9 B;  4QJ3 B;  3ODO A;  2ADZ A;  2R0D A;  2YRY A;  2IFS A;  3WYF B;  1WGU A;  1PMS A;  2ZKM X;  4WSF A;  2KUP A;  1WGQ A;  1GC7 A;  2P0H A;  5HE0 A;  1MI1 A;  1Z87 A;  2HE7 A;  3KRX A;  3ML4 A;  3TVV A;  1U5E A;  1J19 A;  2D2Q A;  1LW3 A;  3FM8 C;  2M38 A;  3KZ1 A;  4GZU A;  2DTC A;  3TCA A;  3PVL A;  3TW1 A;  2D11 A;  2PZ1 A;  1BWN A;  1B55 A;  2KGX B;  1U29 A;  2YVC A;  1XX0 A;  2N0Y A;  2R2Y A;  2YT2 A;  4L1R A;  3HQC A;  3PSC A;  4F7H A;  1SGH A;  4GMX B;  5DIF B;  2JP2 A;  1E5W A;  3A98 B;  1U5D A;  2P8V A;  1V88 A;  3A58 A;  4HAU B;  3DXD A;  1NU2 A;  2EMS A;  3A8P A;  3D8D A;  1MIX A;  2GCJ A;  3U12 A;  1TJ6 A;  4TYZ A;  5KQ4 A;  1W1G A;  2R09 A;  2K2U A;  3A8Q A;  4YON A;  2D9Z A;  3SV1 A;  3KRW A;  1DDW A;  4DXA B;  2I5C A;  4GOU A;  5DHA B;  4WVF B;  3F5R A;  4IOY X;  4GNK B;  2D9Y A;  2LUL A;  2W2W A;  4KAX B;  5IRS A;  3X23 A;  3ZVR A;  1DRO A;  5C6R A;  3NWD A;  1FAO A;  2Q13 A;  1NTV A;  5D27 A;  3VIA A;  2YS1 A;  2COA A;  2CRF A;  2LYD A;  4C0A A;  4HB0 B;  4QXA B;  2GUM A;  3D8E A;  3ULC A;  2YS3 A;  4A5K A;  2EJ8 A;  2J59 M;  2LKO A;  2VSZ A;  4QJ4 B;  2J0M A;  2I1K A;  1T77 A;  3QIJ A;  5LOP B;  1QQG A;  3TFM A;  2J0K A;  2DFK A;  3FEH A;  4IFS A;  3VOQ A;  2MWN B;  2K00 A;  2ELA A;  3FSS A;  1FHW A;  2AEH A;  1FOE A;  3DXC A;  2KCJ A;  5EFX A;  3NSU A;  4HAY B;  4PNK A;  5D3Y A;  4DX8 A;  2CAY A;  1DDV A;  1DDM A;  5JHH A;  1P3R A;  1KZG A;  1H4R A;  3BIN A;  3PP2 A;  2DLW A;  4HB4 B;  1MPH A;  1EGX A;  1KZ7 A;  3V5W A;  1J0W A;  5KQ1 A;  4ZRK A;  1V5U A;  4Z2M B;  3ODX A;  4KVG B;  1UPQ A;  4OT1 A;  2EC1 A;  2KIG A;  1MAI A;  4HDQ A;  1U2B A;  2Z0O A;  5JLJ B;  2VKI A;  4F7G A;  2GS0 A;  3HSA A;  2W2X C;  1V5M A;  1GG3 A;  2LOZ A;  2DN6 A;  2MDX A;  2MFQ A;  3SYX A;  2XQN M;  1XD4 A;  1TQZ A;  2EMT A;  1M7R A;  4HB2 B;  4ZRJ A;  4Z2N A;  1RRP B;  4ZRI A;  1DBH A;  3D8F A;  2P0F A;  2RVB B;  1ZM0 A;  3ZDT A;  1EAZ A;  1X86 A;  4MK0 A;  4CYE A;  4KHO A;  3F0W A;  4HB3 B;  1U5G A;  4KHB B;  2NBV A; 
#chains in the Genus database with same CATH homology
 4DIX A;  4HSI A;  2KR0 A;  3TW1 A;  5I2S A;  4Z2M B;  2KIE A;  3HIE A;  4IFS A;  2Z4D A;  3GYP A;  4IOY X;  4GNK B;  2GCJ A;  3U12 A;  4OT1 A;  4PQ0 A;  3FSS A;  2KIG A;  3NWA A;  4QJ3 B;  2K8E A;  5I2M A;  5IRS A;  2R2Y A;  4Z2N A;  2YT2 A;  4D6W A;  4L1R A;  2K49 A;  4QJ5 B;  2Z13 A;  3NWD A;  2GCL A;  5LG4 B;  2Z14 A;  2ZKM X;  3OHM B;  2FJU B;  1ZYI A;  4QXA B;  2GUM A;  5M4Y B;  3FVC A;  4CSQ A;  3TVV A;  2KUQ A;  4OSN A;  3A58 A;  3NW8 A;  2Z59 A;  4KHO A;  4QJ4 B;  4KHB A;  3NWF A;  4KHB B;  4KHA A;  2RRF A;  4GOU A;  3GYO A;  3TO1 A;  2NBV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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