4K2PA

The structure of a quintuple mutant of the tiam1 ph-cc-ex domain
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
238
structure length
238
Chain Sequence
TVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKLKKMGELQLSSVTDSKAAATILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAART
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title High-resolution structure of the Tiam1 PHn-CC-Ex domain.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords T-lymphoma invasion and metastasis-inducing protein 1
total genus 78
structure length 238
sequence length 238
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-04-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00169 PH PH domain
A PF18385 Tiam_CC_Ex T-lymphoma invasion and metastasis CC-Ex domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.30 Mainly Beta Roll PH-domain like Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 4k2pA01
2K00A 2ELAA 3QBVB 1ZC4B 3P6AA 2DLWA 3WA0A 5C16A 4HDOA 1MK7B 4K17A 4GZUA 4DX8A 2W2WA 5JLJB 1WJ1A 1P6SA 1X11A 1OY2A 4F7GA 3O96A 2W2XD 4KVGB 4CYEA 4TKNA 3SNHA 1EVHA 5DHFB 3A8PA 4Z2NA 4GMVA 4PQ0A 3M1IB 2KCJA 4HAUB 3U7DA 2D9VA 5FI0A 2J0KA 3DXCA 2UVMA 3KRWA 3X23A 3T06A 2E2XA 3AJ4A 4KAXB 2LKOA 2N23A 1U5EA 1J0WA 1W1HA 4C0AA 3KSYA 1WVHA 1EAZA 4IFSA 4HHVA 4HB3B 1BTNA 3HK0A 2UZSA 1TQZA 1AWEA 1Y19B 2GJYA 3DXEA 1U5GA 1FAOA 1PMSA 1XKEA 3IVFA 3HQCA 1WI1A 2DFKA 2ROVA 5D3WA 4GPTB 2DTCA 5CLLB 5C6RA 2OQBA 2MKRA 3ULBA 1XODA 2L1CA 1EF1A 3KZ1A 2D9WA 1M7EA 4HATB 3WYFB 4WJ7A 1Z87A 5DIFB 3UZTA 2YS5A 2COAA 2ZPYA 2M38A 2AL6A 3BJIA 1FGZA 2QKLA 2I1KA 2Y8GA 2W2XC 2CY5A 3VOQA 3GYOA 5JHGA 1DBHA 2YS3A 1RRPB 1XX0A 2LYDA 1NI2A 4HB2B 3MDBC 2VKIA 3OANA 3ZDTA 2DHKA 3LJUX 1MKEA 3F0WA 1MIZB 2DHJA 1XCGA 3PVLA 1FB8A 2MFQA 5KQ4A 2DKPA 1MAIA 2YSZA 1GC7A 2QKMA 2NMBA 3ODOA 2ADZA 3BINA 1Q67A 5HE0A 4WVFB 2DYNA 2LOXA 2R0DA 3ML4A 2EMTA 1K5DB 1ZVRA 1V5PA 1X05A 2M14A 1FHXA 2DX5A 3A8QA 1W1GA 2XQNM 5JP4A 2DHIA 2P8VA 2P0DA 2CRFA 2D11A 1TXDA 3TFMA 2CAYA 4A6FB 5D3XA 1DYNA 4MK0A 4HAYB 5C5BA 4NSWA 4ZRJA 1N3HA 1PLSA 2K2JA 3PVWA 1OMWA 2KUPA 2R09A 4K2OA 1U5FA 3SO6A 1QC6A 3CIKA 3QWMA 3SV1A 2RSGA 2D9XA 1Y5OA 5J3TA 5D27A 2HTHB 3TO1A 2DX1A 2HE7A 4A6FA 2ROZB 3TW1A 2I1JA 4CHJA 1TJ6A 2OTXA 4HAVB 4F7HA 1K5GB 3PZDA 1AQCA 4XWXA 3ULCA 4KHAA 4EKUA 1SHCA 4P7IA 4MY6A 5HE3A 2FJLA 5D3YA 4GXBA 5HE2A 5C79A 2P0HA 2YS1A 2I5CA 1E5WA 1NTVA 4KHBB 2J0MA 3PEGA 1P3RA 3D8FA 5C5BB 5FI1A 2DN6A 4HAXB 1XD4A 4YONA 1V5UA 3QIJA 5DH9B 3A98B 4Y94A 5L81A 1QQGA 1BTKA 2Y7BA 3KRXA 1ZSQA 1EGXA 4H8SA 2DKQA 2N0YA 1NU2A 1DDWA 1U27A 1H10A 2IYBA 2J59M 2YRYA 2Y8FA 1DROA 1UNRA 4Z2MB 1I2HA 2UZRA 2LULA 4K2PA 1X1GA 2LG1A 1J19A 1UPRA 2EJ8A 3PP2A 4ZRKA 3HW2B 2LOZA 2PZ1A 1X86A 2YVCA 2CODA 4HB4B 4KHOA 2L2IA 2GS0A 1V5MA 4A5KA 2KGXB 1ISNA 1RJ2A 3KY9A 2RNRB 4F7UP 1V89A 4NY0A 2JP2A 2Z0PA 1ZC3B 3TCAA 2V76A 5LONB 1U2BA 3FEHA 4TYZA 5DI9B 4YL8A 3MPXA 2DYQA 3PVUA 1MK9B 1B55A 1KZGA 1KZ7A 3N7CA 5J3QA 2RLOA 1MIXA 4PNKA 2AEHA 1LW3A 2CY4A 2RVBB 2GCJA 2MWNB 3U8ZA 1W1DA 4DBBA 5HE1A 1M7RA 4EMOA 2EMSA 4BBKA 4IAPA 4A6HA 1DDVA 3VIAA 4HDQA 4CHMA 1DDMA 4WSFA 2P0FA 4ZRIA 3GYPA 4D0NB 4DXAB 5EFXA 1FGYA 2Q13A 2H7EA 1I7AA 2H7DA 4HB0B 2D4QA 2BCJA 1U5DA 4EJNA 1OQNA 1UEFA 1NTYA 2IFSA 2D10A 2Z0QA 3FSSA 4GMXB 1LB1A 1UNQA 5JHHA 1H4RA 2D9ZA 2COCA 2NZ8B 5J3YA 3V5WA 5LOPB 1V61A 2MDXA 4K81A 1BAKA 2K2UA 2D9YA 2ELBA 4HAWB 1XR0B 4A6KA 1UNPA 1KI1B 3P7ZA 4IOYX 1UPQA 3FM8C 5KCVA 4HAZB 3D8EA 3ODXA 2D2QA 2I5FA 1FOEA 2GCLA 5KQ1A 5GOWB 2YT1A 4MT7A 2COFA 3ZVRA 2J0JA 1WJMA 3G9WA 4B6HA 1GG3A 1WG7A 3AU4A 3DXDA 2RUKB 3F5RA 1BWNA 1MPHA 4GN1A 3PSCA 3AU5A 1V88A 1ZM0A 3PG7A 3TVVA 2EC1A 1SGHA 1WGUA 3CXBB 1X1FA 2VRWB 5DHAB 1PFJA 3NSUA 1IRSA 4L6EA 3SYXA 3D8DA 1U29A 2G35A 3SUZA 3ODWA 2YT0A 2VSZA 1GC6A 2Z0OA 2DA0A 2RGNB 5D3VA 2X18A 1FHOA 5CLQB 1FHWA 1P5TA 1WGQA 3RCPA 4DX90 2YF0A
chains in the Genus database with same CATH superfamily
2K00A 2ELAA 3QBVB 1ZC4B 3P6AA 2DLWA 3WA0A 5C16A 4HDOA 1MK7B 4K17A 4GZUA 4DX8A 3OHMB 2W2WA 5JLJB 1WJ1A 1P6SA 1X11A 2K8EA 1OY2A 4F7GA 3O96A 2W2XD 4KVGB 4CYEA 4TKNA 3SNHA 1EVHA 5DHFB 3A8PA 4Z2NA 4GMVA 4PQ0A 3M1IB 3A58A 2KCJA 4HAUB 3U7DA 2D9VA 5FI0A 2J0KA 2K49A 3DXCA 2UVMA 3KRWA 3X23A 3T06A 2E2XA 3AJ4A 4KAXB 2LKOA 2N23A 1U5EA 1J0WA 1W1HA 1ZYIA 4C0AA 3KSYA 1WVHA 1EAZA 4IFSA 4HHVA 4HB3B 1BTNA 3HK0A 2UZSA 1TQZA 1AWEA 1Y19B 2GJYA 3DXEA 1U5GA 1FAOA 1PMSA 1XKEA 3IVFA 3HQCA 4L1RA 1WI1A 2DFKA 2ROVA 5D3WA 4GPTB 2DTCA 5CLLB 5C6RA 2OQBA 2MKRA 3ULBA 1XODA 2L1CA 1EF1A 3KZ1A 2D9WA 1M7EA 4HATB 3WYFB 4WJ7A 1Z87A 5DIFB 3UZTA 2YS5A 2COAA 2ZPYA 2M38A 2AL6A 2GUMA 3BJIA 1FGZA 2QKLA 2I1KA 2Y8GA 2W2XC 2CY5A 3VOQA 3GYOA 5JHGA 3B77A 1DBHA 4DIXA 2YS3A 1RRPB 2KR0A 1XX0A 2LYDA 1NI2A 3MDBC 4HB2B 1MI1A 2VKIA 3OANA 2KIEA 3ZDTA 2DHKA 3LJUX 1MKEA 4QXAB 3F0WA 1MIZB 2DHJA 1XCGA 3PVLA 4OSNA 1FB8A 2MFQA 5KQ4A 2DKPA 1MAIA 2YSZA 1GC7A 2QKMA 2NMBA 3ODOA 2ADZA 3BINA 1Q67A 5HE0A 4WVFB 2DYNA 2LOXA 2R0DA 3ML4A 2EMTA 1K5DB 1ZVRA 1V5PA 1X05A 2M14A 1FHXA 2DX5A 3A8QA 1W1GA 2XQNM 5JP4A 2DHIA 5M4YB 2P8VA 2P0DA 2CRFA 2D11A 1TXDA 3TFMA 2CAYA 4A6FB 5D3XA 1DYNA 4MK0A 3FVCA 4HAYB 2R2YA 5C5BA 4NSWA 4ZRJA 1N3HA 1PLSA 2K2JA 5I2SA 3PVWA 1OMWA 4CSQA 2KUPA 2R09A 4K2OA 1U5FA 2ZKMX 3SO6A 1QC6A 3CIKA 3QWMA 3SV1A 2RSGA 2D9XA 1Y5OA 5J3TA 5D27A 2HTHB 3TO1A 2DX1A 2HE7A 4A6FA 2ROZB 3TW1A 2I1JA 4CHJA 1TJ6A 2OTXA 4HAVB 4F7HA 3HIEA 1K5GB 3PZDA 1AQCA 4XWXA 3ULCA 4KHAA 2Z4DA 4EKUA 1SHCA 4P7IA 4MY6A 5HE3A 2FJLA 5D3YA 4GXBA 5HE2A 5C79A 2P0HA 2YS1A 3U12A 2I5CA 1E5WA 1NTVA 4KHBB 2J0MA 3PEGA 4QJ4B 1P3RA 3D8FA 5C5BB 5FI1A 2DN6A 4HAXB 1XD4A 4YONA 1V5UA 3QIJA 5DH9B 3A98B 4Y94A 5L81A 1QQGA 1BTKA 2Y7BA 3KRXA 1ZSQA 1EGXA 4H8SA 2DKQA 2N0YA 1NU2A 1DDWA 1U27A 1H10A 2IYBA 2J59M 2YRYA 2Y8FA 1DROA 1UNRA 4Z2MB 1I2HA 2UZRA 2LULA 4K2PA 1X1GA 2LG1A 1J19A 1UPRA 2EJ8A 3PP2A 4ZRKA 3HW2B 2LOZA 2PZ1A 1X86A 2YVCA 2CODA 4HB4B 4KHOA 2L2IA 2GS0A 1V5MA 4A5KA 2KGXB 1ISNA 1RJ2A 3KY9A 2RNRB 4F7UP 1V89A 4NY0A 2JP2A 2Z0PA 1ZC3B 3TCAA 2V76A 5LONB 1U2BA 3FEHA 4TYZA 5DI9B 4YL8A 2NBVA 3MPXA 2DYQA 3PVUA 3DCXA 1MK9B 1B55A 1KZGA 1KZ7A 3N7CA 5J3QA 2RRFA 2RLOA 1MIXA 4PNKA 2AEHA 1LW3A 3NWFA 2CY4A 2RVBB 2GCJA 2MWNB 3U8ZA 1W1DA 4DBBA 5HE1A 1M7RA 4EMOA 2EMSA 4BBKA 4IAPA 4A6HA 1DDVA 3VIAA 4HDQA 4CHMA 1DDMA 4WSFA 2P0FA 4ZRIA 3GYPA 4D0NB 1T77A 4DXAB 5EFXA 1FGYA 2Q13A 2H7EA 5IRSA 4OT1A 1I7AA 2H7DA 4HB0B 2D4QA 2BCJA 1U5DA 4EJNA 1OQNA 2KIGA 1UEFA 1NTYA 2IFSA 2D10A 5LG4B 2Z0QA 2Z13A 3FSSA 4GNKB 4GMXB 1LB1A 1UNQA 2YT2A 3NWAA 5JHHA 1H4RA 2D9ZA 2COCA 2KUQA 2NZ8B 2FJUB 5I2MA 5J3YA 3V5WA 5LOPB 1V61A 2MDXA 4K81A 1BAKA 2K2UA 2D9YA 2ELBA 4HAWB 1XR0B 4A6KA 1UNPA 4QJ5B 1KI1B 3P7ZA 4IOYX 3HSAA 1UPQA 3FM8C 5KCVA 4HAZB 4KHBA 3D8EA 2Z14A 3NW8A 3ODXA 2D2QA 2Z59A 2I5FA 1FOEA 2GCLA 5KQ1A 5GOWB 2YT1A 4MT7A 2COFA 3ZVRA 2J0JA 1WJMA 3G9WA 4B6HA 1GG3A 1WG7A 3AU4A 3DXDA 2RUKB 3F5RA 1BWNA 1MPHA 4GN1A 4GOUA 3PSCA 3AU5A 1V88A 1ZM0A 3PG7A 3TVVA 2EC1A 1SGHA 1WGUA 3CXBB 1X1FA 4QJ3B 2VRWB 5DHAB 1PFJA 3NSUA 1IRSA 4L6EA 3SYXA 3D8DA 1U29A 2G35A 3NWDA 3SUZA 3ODWA 2YT0A 2VSZA 1GC6A 2Z0OA 2DA0A 2RGNB 5D3VA 2X18A 1FHOA 5CLQB 1FHWA 4D6WA 1P5TA 1WGQA 3RCPA 4HSIA 4DX90 2YF0A
chains in the Genus database with same CATH topology
2K00A 2ELAA 3QBVB 1ZC4B 3P6AA 2DLWA 3WA0A 5C16A 4HDOA 1MK7B 4K17A 4GZUA 4DX8A 2W2WA 5JLJB 1WJ1A 1P6SA 1X11A 1OY2A 4F7GA 3O96A 2W2XD 4KVGB 4CYEA 4TKNA 3SNHA 1EVHA 5DHFB 3A8PA 4Z2NA 4GMVA 4PQ0A 3M1IB 2KCJA 4HAUB 3U7DA 2D9VA 5FI0A 2J0KA 3DXCA 2UVMA 3KRWA 3X23A 3T06A 2E2XA 3AJ4A 4KAXB 2LKOA 2N23A 1U5EA 1J0WA 1W1HA 4C0AA 3KSYA 1WVHA 1EAZA 4IFSA 4HHVA 4HB3B 1BTNA 3HK0A 2UZSA 1TQZA 1AWEA 1Y19B 2GJYA 3DXEA 1U5GA 1FAOA 1PMSA 1XKEA 3IVFA 3HQCA 1WI1A 2DFKA 2ROVA 5D3WA 4GPTB 2DTCA 5CLLB 5C6RA 2OQBA 2MKRA 3ULBA 1XODA 2L1CA 1EF1A 3KZ1A 2D9WA 1M7EA 4HATB 3WYFB 4WJ7A 1Z87A 5DIFB 3UZTA 2YS5A 2COAA 2ZPYA 2M38A 2AL6A 3BJIA 1FGZA 2QKLA 2I1KA 2Y8GA 2W2XC 2CY5A 3VOQA 3GYOA 5JHGA 1DBHA 2YS3A 1RRPB 1XX0A 2LYDA 1NI2A 4HB2B 3MDBC 2VKIA 3OANA 3ZDTA 2DHKA 3LJUX 1MKEA 3F0WA 1MIZB 2DHJA 1XCGA 3PVLA 1FB8A 2MFQA 5KQ4A 2DKPA 1MAIA 2YSZA 1GC7A 2QKMA 2NMBA 3ODOA 2ADZA 3BINA 1Q67A 5HE0A 4WVFB 2DYNA 2LOXA 2R0DA 3ML4A 2EMTA 1K5DB 1ZVRA 1V5PA 1X05A 2M14A 1FHXA 2DX5A 3A8QA 1W1GA 2XQNM 5JP4A 2DHIA 2P8VA 2P0DA 2CRFA 2D11A 1TXDA 3TFMA 2CAYA 4A6FB 5D3XA 1DYNA 4MK0A 4HAYB 5C5BA 4NSWA 4ZRJA 1N3HA 1PLSA 2K2JA 3PVWA 1OMWA 2KUPA 2R09A 4K2OA 1U5FA 3SO6A 1QC6A 3CIKA 3QWMA 3SV1A 2RSGA 2D9XA 1Y5OA 5J3TA 5D27A 2HTHB 3TO1A 2DX1A 2HE7A 4A6FA 2ROZB 3TW1A 2I1JA 4CHJA 1TJ6A 2OTXA 4HAVB 4F7HA 1K5GB 3PZDA 1AQCA 4XWXA 3ULCA 4KHAA 4EKUA 1SHCA 4P7IA 4MY6A 5HE3A 2FJLA 5D3YA 4GXBA 5HE2A 5C79A 2P0HA 2YS1A 2I5CA 1E5WA 1NTVA 4KHBB 2J0MA 3PEGA 1P3RA 3D8FA 5C5BB 5FI1A 2DN6A 4HAXB 1XD4A 4YONA 1V5UA 3QIJA 5DH9B 3A98B 4Y94A 5L81A 1QQGA 1BTKA 2Y7BA 3KRXA 1ZSQA 1EGXA 4H8SA 2DKQA 2N0YA 1NU2A 1DDWA 1U27A 1H10A 2IYBA 2J59M 2YRYA 2Y8FA 1DROA 1UNRA 4Z2MB 1I2HA 2UZRA 2LULA 4K2PA 1X1GA 2LG1A 1J19A 1UPRA 2EJ8A 3PP2A 4ZRKA 3HW2B 2LOZA 2PZ1A 1X86A 2YVCA 2CODA 4HB4B 4KHOA 2L2IA 2GS0A 1V5MA 4A5KA 2KGXB 1ISNA 1RJ2A 3KY9A 2RNRB 4F7UP 1V89A 4NY0A 2JP2A 2Z0PA 1ZC3B 3TCAA 2V76A 5LONB 1U2BA 3FEHA 4TYZA 5DI9B 4YL8A 3MPXA 2DYQA 3PVUA 1MK9B 1B55A 1KZGA 1KZ7A 3N7CA 5J3QA 2RLOA 1MIXA 4PNKA 2AEHA 1LW3A 2CY4A 2RVBB 2GCJA 2MWNB 3U8ZA 1W1DA 4DBBA 5HE1A 1M7RA 4EMOA 2EMSA 4BBKA 4IAPA 4A6HA 1DDVA 3VIAA 4HDQA 4CHMA 1DDMA 4WSFA 2P0FA 4ZRIA 3GYPA 4D0NB 4DXAB 5EFXA 1FGYA 2Q13A 2H7EA 1I7AA 2H7DA 4HB0B 2D4QA 2BCJA 1U5DA 4EJNA 1OQNA 1UEFA 1NTYA 2IFSA 2D10A 2Z0QA 3FSSA 4GMXB 1LB1A 1UNQA 5JHHA 1H4RA 2D9ZA 2COCA 2NZ8B 5J3YA 3V5WA 5LOPB 1V61A 2MDXA 4K81A 1BAKA 2K2UA 2D9YA 2ELBA 4HAWB 1XR0B 4A6KA 1UNPA 1KI1B 3P7ZA 4IOYX 1UPQA 3FM8C 5KCVA 4HAZB 3D8EA 3ODXA 2D2QA 2I5FA 1FOEA 2GCLA 5KQ1A 5GOWB 2YT1A 4MT7A 2COFA 3ZVRA 2J0JA 1WJMA 3G9WA 4B6HA 1GG3A 1WG7A 3AU4A 3DXDA 2RUKB 3F5RA 1BWNA 1MPHA 4GN1A 3PSCA 3AU5A 1V88A 1ZM0A 3PG7A 3TVVA 2EC1A 1SGHA 1WGUA 3CXBB 1X1FA 2VRWB 5DHAB 1PFJA 3NSUA 1IRSA 4L6EA 3SYXA 3D8DA 1U29A 2G35A 3SUZA 3ODWA 2YT0A 2VSZA 1GC6A 2Z0OA 2DA0A 2RGNB 5D3VA 2X18A 1FHOA 5CLQB 1FHWA 1P5TA 1WGQA 3RCPA 4DX90 2YF0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2K00 A;  2ELA A;  3QBV B;  1ZC4 B;  3P6A A;  2DLW A;  3WA0 A;  5C16 A;  4HDO A;  1MK7 B;  4K17 A;  4GZU A;  4DX8 A;  2W2W A;  5JLJ B;  1WJ1 A;  1P6S A;  1X11 A;  1OY2 A;  4F7G A;  3O96 A;  2W2X D;  4KVG B;  4CYE A;  4TKN A;  3SNH A;  1EVH A;  5DHF B;  3A8P A;  4Z2N A;  4GMV A;  4PQ0 A;  3M1I B;  2KCJ A;  4HAU B;  3U7D A;  2D9V A;  5FI0 A;  2J0K A;  3DXC A;  2UVM A;  3KRW A;  3X23 A;  3T06 A;  2E2X A;  3AJ4 A;  4KAX B;  2LKO A;  2N23 A;  1U5E A;  1J0W A;  1W1H A;  4C0A A;  3KSY A;  1WVH A;  1EAZ A;  4IFS A;  4HHV A;  4HB3 B;  1BTN A;  3HK0 A;  2UZS A;  1TQZ A;  1AWE A;  1Y19 B;  2GJY A;  3DXE A;  1U5G A;  1FAO A;  1PMS A;  1XKE A;  3IVF A;  3HQC A;  1WI1 A;  2DFK A;  2ROV A;  5D3W A;  4GPT B;  2DTC A;  5CLL B;  5C6R A;  2OQB A;  2MKR A;  3ULB A;  1XOD A;  2L1C A;  1EF1 A;  3KZ1 A;  2D9W A;  1M7E A;  4HAT B;  3WYF B;  4WJ7 A;  1Z87 A;  5DIF B;  3UZT A;  2YS5 A;  2COA A;  2ZPY A;  2M38 A;  2AL6 A;  3BJI A;  1FGZ A;  2QKL A;  2I1K A;  2Y8G A;  2W2X C;  2CY5 A;  3VOQ A;  3GYO A;  5JHG A;  1DBH A;  2YS3 A;  1RRP B;  1XX0 A;  2LYD A;  1NI2 A;  4HB2 B;  3MDB C;  2VKI A;  3OAN A;  3ZDT A;  2DHK A;  3LJU X;  1MKE A;  3F0W A;  1MIZ B;  2DHJ A;  1XCG A;  3PVL A;  1FB8 A;  2MFQ A;  5KQ4 A;  2DKP A;  1MAI A;  2YSZ A;  1GC7 A;  2QKM A;  2NMB A;  3ODO A;  2ADZ A;  3BIN A;  1Q67 A;  5HE0 A;  4WVF B;  2DYN A;  2LOX A;  2R0D A;  3ML4 A;  2EMT A;  1K5D B;  1ZVR A;  1V5P A;  1X05 A;  2M14 A;  1FHX A;  2DX5 A;  3A8Q A;  1W1G A;  2XQN M;  5JP4 A;  2DHI A;  2P8V A;  2P0D A;  2CRF A;  2D11 A;  1TXD A;  3TFM A;  2CAY A;  4A6F B;  5D3X A;  1DYN A;  4MK0 A;  4HAY B;  5C5B A;  4NSW A;  4ZRJ A;  1N3H A;  1PLS A;  2K2J A;  3PVW A;  1OMW A;  2KUP A;  2R09 A;  4K2O A;  1U5F A;  3SO6 A;  1QC6 A;  3CIK A;  3QWM A;  3SV1 A;  2RSG A;  2D9X A;  1Y5O A;  5J3T A;  5D27 A;  2HTH B;  3TO1 A;  2DX1 A;  2HE7 A;  4A6F A;  2ROZ B;  3TW1 A;  2I1J A;  4CHJ A;  1TJ6 A;  2OTX A;  4HAV B;  4F7H A;  1K5G B;  3PZD A;  1AQC A;  4XWX A;  3ULC A;  4KHA A;  4EKU A;  1SHC A;  4P7I A;  4MY6 A;  5HE3 A;  2FJL A;  5D3Y A;  4GXB A;  5HE2 A;  5C79 A;  2P0H A;  2YS1 A;  2I5C A;  1E5W A;  1NTV A;  4KHB B;  2J0M A;  3PEG A;  1P3R A;  3D8F A;  5C5B B;  5FI1 A;  2DN6 A;  4HAX B;  1XD4 A;  4YON A;  1V5U A;  3QIJ A;  5DH9 B;  3A98 B;  4Y94 A;  5L81 A;  1QQG A;  1BTK A;  2Y7B A;  3KRX A;  1ZSQ A;  1EGX A;  4H8S A;  2DKQ A;  2N0Y A;  1NU2 A;  1DDW A;  1U27 A;  1H10 A;  2IYB A;  2J59 M;  2YRY A;  2Y8F A;  1DRO A;  1UNR A;  4Z2M B;  1I2H A;  2UZR A;  2LUL A;  4K2P A;  1X1G A;  2LG1 A;  1J19 A;  1UPR A;  2EJ8 A;  3PP2 A;  4ZRK A;  3HW2 B;  2LOZ A;  2PZ1 A;  1X86 A;  2YVC A;  2COD A;  4HB4 B;  4KHO A;  2L2I A;  2GS0 A;  1V5M A;  4A5K A;  2KGX B;  1ISN A;  1RJ2 A;  3KY9 A;  2RNR B;  4F7U P;  1V89 A;  4NY0 A;  2JP2 A;  2Z0P A;  1ZC3 B;  3TCA A;  2V76 A;  5LON B;  1U2B A;  3FEH A;  4TYZ A;  5DI9 B;  4YL8 A;  3MPX A;  2DYQ A;  3PVU A;  1MK9 B;  1B55 A;  1KZG A;  1KZ7 A;  3N7C A;  5J3Q A;  2RLO A;  1MIX A;  4PNK A;  2AEH A;  1LW3 A;  2CY4 A;  2RVB B;  2GCJ A;  2MWN B;  3U8Z A;  1W1D A;  4DBB A;  5HE1 A;  1M7R A;  4EMO A;  2EMS A;  4BBK A;  4IAP A;  4A6H A;  1DDV A;  3VIA A;  4HDQ A;  4CHM A;  1DDM A;  4WSF A;  2P0F A;  4ZRI A;  3GYP A;  4D0N B;  4DXA B;  5EFX A;  1FGY A;  2Q13 A;  2H7E A;  1I7A A;  2H7D A;  4HB0 B;  2D4Q A;  2BCJ A;  1U5D A;  4EJN A;  1OQN A;  1UEF A;  1NTY A;  2IFS A;  2D10 A;  2Z0Q A;  3FSS A;  4GMX B;  1LB1 A;  1UNQ A;  5JHH A;  1H4R A;  2D9Z A;  2COC A;  2NZ8 B;  5J3Y A;  3V5W A;  5LOP B;  1V61 A;  2MDX A;  4K81 A;  1BAK A;  2K2U A;  2D9Y A;  2ELB A;  4HAW B;  1XR0 B;  4A6K A;  1UNP A;  1KI1 B;  3P7Z A;  4IOY X;  1UPQ A;  3FM8 C;  5KCV A;  4HAZ B;  3D8E A;  3ODX A;  2D2Q A;  2I5F A;  1FOE A;  2GCL A;  5KQ1 A;  5GOW B;  2YT1 A;  4MT7 A;  2COF A;  3ZVR A;  2J0J A;  1WJM A;  3G9W A;  4B6H A;  1GG3 A;  1WG7 A;  3AU4 A;  3DXD A;  2RUK B;  3F5R A;  1BWN A;  1MPH A;  4GN1 A;  3PSC A;  3AU5 A;  1V88 A;  1ZM0 A;  3PG7 A;  3TVV A;  2EC1 A;  1SGH A;  1WGU A;  3CXB B;  1X1F A;  2VRW B;  5DHA B;  1PFJ A;  3NSU A;  1IRS A;  4L6E A;  3SYX A;  3D8D A;  1U29 A;  2G35 A;  3SUZ A;  3ODW A;  2YT0 A;  2VSZ A;  1GC6 A;  2Z0O A;  2DA0 A;  2RGN B;  5D3V A;  2X18 A;  1FHO A;  5CLQ B;  1FHW A;  1P5T A;  1WGQ A;  3RCP A;  4DX9 0;  2YF0 A; 
#chains in the Genus database with same CATH topology
 2K00 A;  2ELA A;  3QBV B;  1ZC4 B;  3P6A A;  2DLW A;  3WA0 A;  5C16 A;  4HDO A;  1MK7 B;  4K17 A;  4GZU A;  4DX8 A;  3OHM B;  2W2W A;  5JLJ B;  1WJ1 A;  1P6S A;  1X11 A;  2K8E A;  1OY2 A;  4F7G A;  3O96 A;  2W2X D;  4KVG B;  4CYE A;  4TKN A;  3SNH A;  1EVH A;  5DHF B;  3A8P A;  4Z2N A;  4GMV A;  4PQ0 A;  3M1I B;  3A58 A;  2KCJ A;  4HAU B;  3U7D A;  2D9V A;  5FI0 A;  2J0K A;  2K49 A;  3DXC A;  2UVM A;  3KRW A;  3X23 A;  3T06 A;  2E2X A;  3AJ4 A;  4KAX B;  2LKO A;  2N23 A;  1U5E A;  1J0W A;  1W1H A;  1ZYI A;  4C0A A;  3KSY A;  1WVH A;  1EAZ A;  4IFS A;  4HHV A;  4HB3 B;  1BTN A;  3HK0 A;  2UZS A;  1TQZ A;  1AWE A;  1Y19 B;  2GJY A;  3DXE A;  1U5G A;  1FAO A;  1PMS A;  1XKE A;  3IVF A;  3HQC A;  4L1R A;  1WI1 A;  2DFK A;  2ROV A;  5D3W A;  4GPT B;  2DTC A;  5CLL B;  5C6R A;  2OQB A;  2MKR A;  3ULB A;  1XOD A;  2L1C A;  1EF1 A;  3KZ1 A;  2D9W A;  1M7E A;  4HAT B;  3WYF B;  4WJ7 A;  1Z87 A;  5DIF B;  3UZT A;  2YS5 A;  2COA A;  2ZPY A;  2M38 A;  2AL6 A;  2GUM A;  3BJI A;  1FGZ A;  2QKL A;  2I1K A;  2Y8G A;  2W2X C;  2CY5 A;  3VOQ A;  3GYO A;  5JHG A;  3B77 A;  1DBH A;  4DIX A;  2YS3 A;  1RRP B;  2KR0 A;  1XX0 A;  2LYD A;  1NI2 A;  3MDB C;  4HB2 B;  1MI1 A;  2VKI A;  3OAN A;  2KIE A;  3ZDT A;  2DHK A;  3LJU X;  1MKE A;  4QXA B;  3F0W A;  1MIZ B;  2DHJ A;  1XCG A;  3PVL A;  4OSN A;  1FB8 A;  2MFQ A;  5KQ4 A;  2DKP A;  1MAI A;  2YSZ A;  1GC7 A;  2QKM A;  2NMB A;  3ODO A;  2ADZ A;  3BIN A;  1Q67 A;  5HE0 A;  4WVF B;  2DYN A;  2LOX A;  2R0D A;  3ML4 A;  2EMT A;  1K5D B;  1ZVR A;  1V5P A;  1X05 A;  2M14 A;  1FHX A;  2DX5 A;  3A8Q A;  1W1G A;  2XQN M;  5JP4 A;  2DHI A;  5M4Y B;  2P8V A;  2P0D A;  2CRF A;  2D11 A;  1TXD A;  3TFM A;  2CAY A;  4A6F B;  5D3X A;  1DYN A;  4MK0 A;  3FVC A;  4HAY B;  2R2Y A;  5C5B A;  4NSW A;  4ZRJ A;  1N3H A;  1PLS A;  2K2J A;  5I2S A;  3PVW A;  1OMW A;  4CSQ A;  2KUP A;  2R09 A;  4K2O A;  1U5F A;  2ZKM X;  3SO6 A;  1QC6 A;  3CIK A;  3QWM A;  3SV1 A;  2RSG A;  2D9X A;  1Y5O A;  5J3T A;  5D27 A;  2HTH B;  3TO1 A;  2DX1 A;  2HE7 A;  4A6F A;  2ROZ B;  3TW1 A;  2I1J A;  4CHJ A;  1TJ6 A;  2OTX A;  4HAV B;  4F7H A;  3HIE A;  1K5G B;  3PZD A;  1AQC A;  4XWX A;  3ULC A;  4KHA A;  2Z4D A;  4EKU A;  1SHC A;  4P7I A;  4MY6 A;  5HE3 A;  2FJL A;  5D3Y A;  4GXB A;  5HE2 A;  5C79 A;  2P0H A;  2YS1 A;  3U12 A;  2I5C A;  1E5W A;  1NTV A;  4KHB B;  2J0M A;  3PEG A;  4QJ4 B;  1P3R A;  3D8F A;  5C5B B;  5FI1 A;  2DN6 A;  4HAX B;  1XD4 A;  4YON A;  1V5U A;  3QIJ A;  5DH9 B;  3A98 B;  4Y94 A;  5L81 A;  1QQG A;  1BTK A;  2Y7B A;  3KRX A;  1ZSQ A;  1EGX A;  4H8S A;  2DKQ A;  2N0Y A;  1NU2 A;  1DDW A;  1U27 A;  1H10 A;  2IYB A;  2J59 M;  2YRY A;  2Y8F A;  1DRO A;  1UNR A;  4Z2M B;  1I2H A;  2UZR A;  2LUL A;  4K2P A;  1X1G A;  2LG1 A;  1J19 A;  1UPR A;  2EJ8 A;  3PP2 A;  4ZRK A;  3HW2 B;  2LOZ A;  2PZ1 A;  1X86 A;  2YVC A;  2COD A;  4HB4 B;  4KHO A;  2L2I A;  2GS0 A;  1V5M A;  4A5K A;  2KGX B;  1ISN A;  1RJ2 A;  3KY9 A;  2RNR B;  4F7U P;  1V89 A;  4NY0 A;  2JP2 A;  2Z0P A;  1ZC3 B;  3TCA A;  2V76 A;  5LON B;  1U2B A;  3FEH A;  4TYZ A;  5DI9 B;  4YL8 A;  2NBV A;  3MPX A;  2DYQ A;  3PVU A;  3DCX A;  1MK9 B;  1B55 A;  1KZG A;  1KZ7 A;  3N7C A;  5J3Q A;  2RRF A;  2RLO A;  1MIX A;  4PNK A;  2AEH A;  1LW3 A;  3NWF A;  2CY4 A;  2RVB B;  2GCJ A;  2MWN B;  3U8Z A;  1W1D A;  4DBB A;  5HE1 A;  1M7R A;  4EMO A;  2EMS A;  4BBK A;  4IAP A;  4A6H A;  1DDV A;  3VIA A;  4HDQ A;  4CHM A;  1DDM A;  4WSF A;  2P0F A;  4ZRI A;  3GYP A;  4D0N B;  1T77 A;  4DXA B;  5EFX A;  1FGY A;  2Q13 A;  2H7E A;  5IRS A;  4OT1 A;  1I7A A;  2H7D A;  4HB0 B;  2D4Q A;  2BCJ A;  1U5D A;  4EJN A;  1OQN A;  2KIG A;  1UEF A;  1NTY A;  2IFS A;  2D10 A;  5LG4 B;  2Z0Q A;  2Z13 A;  3FSS A;  4GNK B;  4GMX B;  1LB1 A;  1UNQ A;  2YT2 A;  3NWA A;  5JHH A;  1H4R A;  2D9Z A;  2COC A;  2KUQ A;  2NZ8 B;  2FJU B;  5I2M A;  5J3Y A;  3V5W A;  5LOP B;  1V61 A;  2MDX A;  4K81 A;  1BAK A;  2K2U A;  2D9Y A;  2ELB A;  4HAW B;  1XR0 B;  4A6K A;  1UNP A;  4QJ5 B;  1KI1 B;  3P7Z A;  4IOY X;  3HSA A;  1UPQ A;  3FM8 C;  5KCV A;  4HAZ B;  4KHB A;  3D8E A;  2Z14 A;  3NW8 A;  3ODX A;  2D2Q A;  2Z59 A;  2I5F A;  1FOE A;  2GCL A;  5KQ1 A;  5GOW B;  2YT1 A;  4MT7 A;  2COF A;  3ZVR A;  2J0J A;  1WJM A;  3G9W A;  4B6H A;  1GG3 A;  1WG7 A;  3AU4 A;  3DXD A;  2RUK B;  3F5R A;  1BWN A;  1MPH A;  4GN1 A;  4GOU A;  3PSC A;  3AU5 A;  1V88 A;  1ZM0 A;  3PG7 A;  3TVV A;  2EC1 A;  1SGH A;  1WGU A;  3CXB B;  1X1F A;  4QJ3 B;  2VRW B;  5DHA B;  1PFJ A;  3NSU A;  1IRS A;  4L6E A;  3SYX A;  3D8D A;  1U29 A;  2G35 A;  3NWD A;  3SUZ A;  3ODW A;  2YT0 A;  2VSZ A;  1GC6 A;  2Z0O A;  2DA0 A;  2RGN B;  5D3V A;  2X18 A;  1FHO A;  5CLQ B;  1FHW A;  4D6W A;  1P5T A;  1WGQ A;  3RCP A;  4HSI A;  4DX9 0;  2YF0 A; 
#chains in the Genus database with same CATH homology
 2K00 A;  2ELA A;  3QBV B;  1ZC4 B;  3P6A A;  2DLW A;  3WA0 A;  5C16 A;  4HDO A;  1MK7 B;  4K17 A;  4GZU A;  4DX8 A;  2W2W A;  5JLJ B;  1WJ1 A;  1P6S A;  1X11 A;  1OY2 A;  4F7G A;  3O96 A;  2W2X D;  4KVG B;  4CYE A;  4TKN A;  3SNH A;  1EVH A;  5DHF B;  3A8P A;  4Z2N A;  4GMV A;  4PQ0 A;  3M1I B;  2KCJ A;  4HAU B;  3U7D A;  2D9V A;  5FI0 A;  2J0K A;  3DXC A;  2UVM A;  3KRW A;  3X23 A;  3T06 A;  2E2X A;  3AJ4 A;  4KAX B;  2LKO A;  2N23 A;  1U5E A;  1J0W A;  1W1H A;  4C0A A;  3KSY A;  1WVH A;  1EAZ A;  4IFS A;  4HHV A;  4HB3 B;  1BTN A;  3HK0 A;  2UZS A;  1TQZ A;  1AWE A;  1Y19 B;  2GJY A;  3DXE A;  1U5G A;  1FAO A;  1PMS A;  1XKE A;  3IVF A;  3HQC A;  1WI1 A;  2DFK A;  2ROV A;  5D3W A;  4GPT B;  2DTC A;  5CLL B;  5C6R A;  2OQB A;  2MKR A;  3ULB A;  1XOD A;  2L1C A;  1EF1 A;  3KZ1 A;  2D9W A;  1M7E A;  4HAT B;  3WYF B;  4WJ7 A;  1Z87 A;  5DIF B;  3UZT A;  2YS5 A;  2COA A;  2ZPY A;  2M38 A;  2AL6 A;  3BJI A;  1FGZ A;  2QKL A;  2I1K A;  2Y8G A;  2W2X C;  2CY5 A;  3VOQ A;  3GYO A;  5JHG A;  1DBH A;  2YS3 A;  1RRP B;  1XX0 A;  2LYD A;  1NI2 A;  4HB2 B;  3MDB C;  2VKI A;  3OAN A;  3ZDT A;  2DHK A;  3LJU X;  1MKE A;  3F0W A;  1MIZ B;  2DHJ A;  1XCG A;  3PVL A;  1FB8 A;  2MFQ A;  5KQ4 A;  2DKP A;  1MAI A;  2YSZ A;  1GC7 A;  2QKM A;  2NMB A;  3ODO A;  2ADZ A;  3BIN A;  1Q67 A;  5HE0 A;  4WVF B;  2DYN A;  2LOX A;  2R0D A;  3ML4 A;  2EMT A;  1K5D B;  1ZVR A;  1V5P A;  1X05 A;  2M14 A;  1FHX A;  2DX5 A;  3A8Q A;  1W1G A;  2XQN M;  5JP4 A;  2DHI A;  2P8V A;  2P0D A;  2CRF A;  2D11 A;  1TXD A;  3TFM A;  2CAY A;  4A6F B;  5D3X A;  1DYN A;  4MK0 A;  4HAY B;  5C5B A;  4NSW A;  4ZRJ A;  1N3H A;  1PLS A;  2K2J A;  3PVW A;  1OMW A;  2KUP A;  2R09 A;  4K2O A;  1U5F A;  3SO6 A;  1QC6 A;  3CIK A;  3QWM A;  3SV1 A;  2RSG A;  2D9X A;  1Y5O A;  5J3T A;  5D27 A;  2HTH B;  3TO1 A;  2DX1 A;  2HE7 A;  4A6F A;  2ROZ B;  3TW1 A;  2I1J A;  4CHJ A;  1TJ6 A;  2OTX A;  4HAV B;  4F7H A;  1K5G B;  3PZD A;  1AQC A;  4XWX A;  3ULC A;  4KHA A;  4EKU A;  1SHC A;  4P7I A;  4MY6 A;  5HE3 A;  2FJL A;  5D3Y A;  4GXB A;  5HE2 A;  5C79 A;  2P0H A;  2YS1 A;  2I5C A;  1E5W A;  1NTV A;  4KHB B;  2J0M A;  3PEG A;  1P3R A;  3D8F A;  5C5B B;  5FI1 A;  2DN6 A;  4HAX B;  1XD4 A;  4YON A;  1V5U A;  3QIJ A;  5DH9 B;  3A98 B;  4Y94 A;  5L81 A;  1QQG A;  1BTK A;  2Y7B A;  3KRX A;  1ZSQ A;  1EGX A;  4H8S A;  2DKQ A;  2N0Y A;  1NU2 A;  1DDW A;  1U27 A;  1H10 A;  2IYB A;  2J59 M;  2YRY A;  2Y8F A;  1DRO A;  1UNR A;  4Z2M B;  1I2H A;  2UZR A;  2LUL A;  4K2P A;  1X1G A;  2LG1 A;  1J19 A;  1UPR A;  2EJ8 A;  3PP2 A;  4ZRK A;  3HW2 B;  2LOZ A;  2PZ1 A;  1X86 A;  2YVC A;  2COD A;  4HB4 B;  4KHO A;  2L2I A;  2GS0 A;  1V5M A;  4A5K A;  2KGX B;  1ISN A;  1RJ2 A;  3KY9 A;  2RNR B;  4F7U P;  1V89 A;  4NY0 A;  2JP2 A;  2Z0P A;  1ZC3 B;  3TCA A;  2V76 A;  5LON B;  1U2B A;  3FEH A;  4TYZ A;  5DI9 B;  4YL8 A;  3MPX A;  2DYQ A;  3PVU A;  1MK9 B;  1B55 A;  1KZG A;  1KZ7 A;  3N7C A;  5J3Q A;  2RLO A;  1MIX A;  4PNK A;  2AEH A;  1LW3 A;  2CY4 A;  2RVB B;  2GCJ A;  2MWN B;  3U8Z A;  1W1D A;  4DBB A;  5HE1 A;  1M7R A;  4EMO A;  2EMS A;  4BBK A;  4IAP A;  4A6H A;  1DDV A;  3VIA A;  4HDQ A;  4CHM A;  1DDM A;  4WSF A;  2P0F A;  4ZRI A;  3GYP A;  4D0N B;  4DXA B;  5EFX A;  1FGY A;  2Q13 A;  2H7E A;  1I7A A;  2H7D A;  4HB0 B;  2D4Q A;  2BCJ A;  1U5D A;  4EJN A;  1OQN A;  1UEF A;  1NTY A;  2IFS A;  2D10 A;  2Z0Q A;  3FSS A;  4GMX B;  1LB1 A;  1UNQ A;  5JHH A;  1H4R A;  2D9Z A;  2COC A;  2NZ8 B;  5J3Y A;  3V5W A;  5LOP B;  1V61 A;  2MDX A;  4K81 A;  1BAK A;  2K2U A;  2D9Y A;  2ELB A;  4HAW B;  1XR0 B;  4A6K A;  1UNP A;  1KI1 B;  3P7Z A;  4IOY X;  1UPQ A;  3FM8 C;  5KCV A;  4HAZ B;  3D8E A;  3ODX A;  2D2Q A;  2I5F A;  1FOE A;  2GCL A;  5KQ1 A;  5GOW B;  2YT1 A;  4MT7 A;  2COF A;  3ZVR A;  2J0J A;  1WJM A;  3G9W A;  4B6H A;  1GG3 A;  1WG7 A;  3AU4 A;  3DXD A;  2RUK B;  3F5R A;  1BWN A;  1MPH A;  4GN1 A;  3PSC A;  3AU5 A;  1V88 A;  1ZM0 A;  3PG7 A;  3TVV A;  2EC1 A;  1SGH A;  1WGU A;  3CXB B;  1X1F A;  2VRW B;  5DHA B;  1PFJ A;  3NSU A;  1IRS A;  4L6E A;  3SYX A;  3D8D A;  1U29 A;  2G35 A;  3SUZ A;  3ODW A;  2YT0 A;  2VSZ A;  1GC6 A;  2Z0O A;  2DA0 A;  2RGN B;  5D3V A;  2X18 A;  1FHO A;  5CLQ B;  1FHW A;  1P5T A;  1WGQ A;  3RCP A;  4DX9 0;  2YF0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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