1ZYIA

Solution structure of icln, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
116
structure length
116
Chain Sequence
QQQPETEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDLNAYPREHLYVMVNAKFGEESKESVAEEEDSDDDVEPIAEFRFVPSDKSALEAMFTAMCECQAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4
pubmed doi rcsb
molecule tags Translation
source organism Canis lupus familiaris
molecule keywords Methylosome subunit pICln
total genus 14
structure length 116
sequence length 116
ec nomenclature
pdb deposition date 2005-06-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.60 Mainly Beta Roll PH-domain like PH-domain like 1zyiA00
1ZYIA
chains in the Genus database with same CATH superfamily
2COFA 3TCAA 2KR0A 4KHAA 1ZC3B 4MT7A 3G9WA 4A6FA 5JP4A 1UNQA 3QBVB 4F7GA 2YS5A 3FM8C 1EAZA 4ZRJA 2R2YA 1M7EA 2CY4A 4HAZB 4GMVA 4QXAB 4A5KA 1MK7B 3VIAA 2Z59A 1XKEA 2IYBA 4DX8A 3SO6A 2OTXA 4Z2NA 2K2UA 1I7AA 1FB8A 3UZTA 5JHGA 3VOQA 2DTCA 4GNKB 2M38A 4K2PA 3HK0A 3ZDTA 5M4YB 3N7CA 3F0WA 2Z4DA 2D9VA 5J3QA 3CIKA 4QJ3B 2GCJA 4HDOA 1MI1A 3A8QA 2ROZB 3PG7A 2AEHA 4CHJA 4DX90 3U7DA 2G35A 2D2QA 1XODA 3TO1A 1MAIA 4CHMA 5HE0A 2DHIA 2GS0A 2Y8FA 1U27A 3RCPA 1RJ2A 2ROVA 4GMXB 3DCXA 2DFKA 2W2XC 5LG4B 2K2JA 4IAPA 3O96A 1T77A 4HB0B 1GC6A 2QKMA 5L81A 3SNHA 1TJ6A 2K00A 4CYEA 3PSCA 2YT0A 2EMSA 2YSZA 3OHMB 2DYQA 2K49A 2R0DA 2RRFA 1EGXA 3ODWA 2J0KA 2CRFA 4HSIA 2YRYA 3HIEA 1GG3A 1XD4A 2H7EA 2P8VA 4MY6A 1XX0A 5C5BA 4P7IA 1DDMA 1J19A 4KHBB 2KCJA 1W1GA 1DYNA 3X23A 2W2WA 1P6SA 1U5EA 4L6EA 2UZSA 3PVWA 1WGQA 2HE7A 5J3YA 5KQ1A 1BAKA 1FOEA 2Z0QA 1PMSA 2RVBB 1BTKA 1WJ1A 2NBVA 4ZRIA 3NWDA 1FHWA 3KRWA 2DKPA 1WJMA 5FI0A 1Y19B 1MKEA 4HB2B 2OQBA 5DIFB 1TXDA 5LONB 1FHOA 1FGZA 2LULA 4DIXA 4D0NB 5HE1A 3B77A 2YVCA 2P0DA 4WVFB 4TYZA 2Z0OA 1UEFA 1Q67A 2D9WA 3D8EA 1U5GA 3MPXA 2HTHB 2X18A 2J0JA 5JLJB 1XR0B 1EVHA 1U2BA 1K5GB 1RRPB 4CSQA 3DXDA 1W1DA 3KZ1A 2FJUB 1ZYIA 5D3YA 4NY0A 3LJUX 2LKOA 1V61A 2CODA 2K8EA 1KZ7A 1B55A 2GJYA 2RSGA 2MFQA 4A6KA 3GYOA 3PP2A 1KZGA 4H8SA 3PVLA 2L2IA 3CXBB 3MDBC 4KHBA 2I5FA 3OANA 3FSSA 2Y8GA 4Z2MB 3QWMA 3DXCA 5J3TA 5DH9B 1OMWA 2IFSA 5D27A 1WGUA 3AU4A 4KVGB 2I1JA 2KUPA 3NWAA 4IFSA 2YT1A 4GZUA 2VSZA 4B6HA 1OQNA 3KRXA 2RNRB 2GUMA 4ZRKA 4NSWA 4QJ4B 2DA0A 1Y5OA 1UPQA 4GXBA 5JHHA 3A98B 5CLQB 1NTVA 4A6FB 5DI9B 5C16A 1SHCA 1X11A 4EJNA 2CAYA 3SV1A 3HSAA 4K81A 4HB4B 1ZM0A 5HE2A 2EMTA 2ELBA 1NTYA 2DN6A 3GYPA 4F7HA 1FAOA 2MKRA 4GN1A 5C6RA 3ODOA 1WI1A 3WYFB 2E2XA 3SYXA 1X1FA 1Z87A 3P7ZA 2EJ8A 2Z13A 1V5UA 4F7UP 1MIZB 2LYDA 1WG7A 4D6WA 1ZC4B 1KI1B 4GPTB 2COAA 1BTNA 4OT1A 3AJ4A 2ZKMX 5EFXA 1X1GA 3HQCA 1SGHA 4EMOA 2N23A 4HB3B 5D3VA 3A58A 4HDQA 2YT2A 3NW8A 1ISNA 3P6AA 2YS3A 1DROA 1GC7A 3PVUA 1QQGA 2LOZA 1ZVRA 2D9YA 1DDVA 2RGNB 4OSNA 5FI1A 4KHOA 1K5DB 2RLOA 4L1RA 1I2HA 2MDXA 3KY9A 5KCVA 1DBHA 1P5TA 2XQNM 1P3RA 4EKUA 2KIEA 2N0YA 5CLLB 1LB1A 2DLWA 2J59M 1H10A 3WA0A 3TFMA 3M1IB 5D3WA 4BBKA 2MWNB 2R09A 5D3XA 4TKNA 3TW1A 1U29A 4IOYX 5GOWB 4HAYB 4MK0A 2UVMA 1H4RA 2DYNA 2NZ8B 1BWNA 2V76A 1X86A 5C79A 2LG1A 4K17A 3V5WA 4WJ7A 1FGYA 2D9XA 4WSFA 1V88A 1UNPA 3PZDA 3DXEA 1M7RA 4PQ0A 5C5BB 2DHJA 2ADZA 5KQ4A 2BCJA 2ELAA 4HAXB 2DHKA 4Y94A 2KGXB 3D8FA 4HATB 2M14A 3PEGA 1FHXA 1DDWA 1IRSA 2W2XD 4DBBA 5I2MA 1PFJA 2QKLA 3D8DA 3FEHA 2J0MA 3AU5A 2DKQA 1AQCA 5DHFB 1J0WA 4HAVB 3QIJA 1NI2A 1OY2A 3U12A 2ZPYA 1X05A 3A8PA 2I5CA 5LOPB 1QC6A 4HAWB 2YS1A 3ULCA 4DXAB 3ODXA 2D4QA 2FJLA 2UZRA 1XCGA 3NSUA 2GCLA 1ZSQA 2D10A 4YONA 4HAUB 2P0FA 2AL6A 2LOXA 4GOUA 2I1KA 4KAXB 1MIXA 2KUQA 1V89A 2RUKB 2DX1A 1U5DA 1MK9B 1E5WA 5DHAB 2COCA 2KIGA 3T06A 1W1HA 3KSYA 2CY5A 4K2OA 1TQZA 4XWXA 2Y7BA 4C0AA 5I2SA 3IVFA 2D11A 4A6HA 1AWEA 2Z0PA 3ZVRA 5HE3A 4QJ5B 2Q13A 3BJIA 1UNRA 2VKIA 2DX5A 4PNKA 2Z14A 2PZ1A 2JP2A 3ULBA 3SUZA 2L1CA 3F5RA 3FVCA 1WVHA 1LW3A 1U5FA 4HHVA 2VRWB 1PLSA 2D9ZA 3BINA 1V5MA 1UPRA 4YL8A 3ML4A 3HW2B 1N3HA 1MPHA 1EF1A 3TVVA 2YF0A 1NU2A 2P0HA 2NMBA 2EC1A 1V5PA 5IRSA 2H7DA 3NWFA 3U8ZA
chains in the Genus database with same CATH topology
2YT2A 4QJ5B 4KHBA 2KUQA 3NW8A 2KR0A 3FSSA 4PQ0A 4KHAA 4CSQA 4KHBB 2Z14A 3TW1A 2FJUB 3U12A 1ZYIA 2KIGA 4IOYX 2Z13A 4Z2MB 4GNKB 3TO1A 3FVCA 4D6WA 4OSNA 3NWDA 2R2YA 4KHOA 5M4YB 2K8EA 4DIXA 3OHMB 3NWAA 4IFSA 2K49A 4L1RA 4QXAB 5I2MA 2RRFA 2GCLA 2Z4DA 4HSIA 4OT1A 4QJ3B 5I2SA 2ZKMX 3GYPA 2Z59A 3HIEA 3NWFA 3GYOA 3TVVA 2KIEA 2GCJA 2NBVA 5IRSA 4Z2NA 5LG4B 3A58A 2GUMA 4GOUA 4QJ4B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZYI A; 
#chains in the Genus database with same CATH topology
 2COF A;  3TCA A;  2KR0 A;  4KHA A;  1ZC3 B;  4MT7 A;  3G9W A;  4A6F A;  5JP4 A;  1UNQ A;  3QBV B;  4F7G A;  2YS5 A;  3FM8 C;  1EAZ A;  4ZRJ A;  2R2Y A;  1M7E A;  2CY4 A;  4HAZ B;  4GMV A;  4QXA B;  4A5K A;  1MK7 B;  3VIA A;  2Z59 A;  1XKE A;  2IYB A;  4DX8 A;  3SO6 A;  2OTX A;  4Z2N A;  2K2U A;  1I7A A;  1FB8 A;  3UZT A;  5JHG A;  3VOQ A;  2DTC A;  4GNK B;  2M38 A;  4K2P A;  3HK0 A;  3ZDT A;  5M4Y B;  3N7C A;  3F0W A;  2Z4D A;  2D9V A;  5J3Q A;  3CIK A;  4QJ3 B;  2GCJ A;  4HDO A;  1MI1 A;  3A8Q A;  2ROZ B;  3PG7 A;  2AEH A;  4CHJ A;  4DX9 0;  3U7D A;  2G35 A;  2D2Q A;  1XOD A;  3TO1 A;  1MAI A;  4CHM A;  5HE0 A;  2DHI A;  2GS0 A;  2Y8F A;  1U27 A;  3RCP A;  1RJ2 A;  2ROV A;  4GMX B;  3DCX A;  2DFK A;  2W2X C;  5LG4 B;  2K2J A;  4IAP A;  3O96 A;  1T77 A;  4HB0 B;  1GC6 A;  2QKM A;  5L81 A;  3SNH A;  1TJ6 A;  2K00 A;  4CYE A;  3PSC A;  2YT0 A;  2EMS A;  2YSZ A;  3OHM B;  2DYQ A;  2K49 A;  2R0D A;  2RRF A;  1EGX A;  3ODW A;  2J0K A;  2CRF A;  4HSI A;  2YRY A;  3HIE A;  1GG3 A;  1XD4 A;  2H7E A;  2P8V A;  4MY6 A;  1XX0 A;  5C5B A;  4P7I A;  1DDM A;  1J19 A;  4KHB B;  2KCJ A;  1W1G A;  1DYN A;  3X23 A;  2W2W A;  1P6S A;  1U5E A;  4L6E A;  2UZS A;  3PVW A;  1WGQ A;  2HE7 A;  5J3Y A;  5KQ1 A;  1BAK A;  1FOE A;  2Z0Q A;  1PMS A;  2RVB B;  1BTK A;  1WJ1 A;  2NBV A;  4ZRI A;  3NWD A;  1FHW A;  3KRW A;  2DKP A;  1WJM A;  5FI0 A;  1Y19 B;  1MKE A;  4HB2 B;  2OQB A;  5DIF B;  1TXD A;  5LON B;  1FHO A;  1FGZ A;  2LUL A;  4DIX A;  4D0N B;  5HE1 A;  3B77 A;  2YVC A;  2P0D A;  4WVF B;  4TYZ A;  2Z0O A;  1UEF A;  1Q67 A;  2D9W A;  3D8E A;  1U5G A;  3MPX A;  2HTH B;  2X18 A;  2J0J A;  5JLJ B;  1XR0 B;  1EVH A;  1U2B A;  1K5G B;  1RRP B;  4CSQ A;  3DXD A;  1W1D A;  3KZ1 A;  2FJU B;  1ZYI A;  5D3Y A;  4NY0 A;  3LJU X;  2LKO A;  1V61 A;  2COD A;  2K8E A;  1KZ7 A;  1B55 A;  2GJY A;  2RSG A;  2MFQ A;  4A6K A;  3GYO A;  3PP2 A;  1KZG A;  4H8S A;  3PVL A;  2L2I A;  3CXB B;  3MDB C;  4KHB A;  2I5F A;  3OAN A;  3FSS A;  2Y8G A;  4Z2M B;  3QWM A;  3DXC A;  5J3T A;  5DH9 B;  1OMW A;  2IFS A;  5D27 A;  1WGU A;  3AU4 A;  4KVG B;  2I1J A;  2KUP A;  3NWA A;  4IFS A;  2YT1 A;  4GZU A;  2VSZ A;  4B6H A;  1OQN A;  3KRX A;  2RNR B;  2GUM A;  4ZRK A;  4NSW A;  4QJ4 B;  2DA0 A;  1Y5O A;  1UPQ A;  4GXB A;  5JHH A;  3A98 B;  5CLQ B;  1NTV A;  4A6F B;  5DI9 B;  5C16 A;  1SHC A;  1X11 A;  4EJN A;  2CAY A;  3SV1 A;  3HSA A;  4K81 A;  4HB4 B;  1ZM0 A;  5HE2 A;  2EMT A;  2ELB A;  1NTY A;  2DN6 A;  3GYP A;  4F7H A;  1FAO A;  2MKR A;  4GN1 A;  5C6R A;  3ODO A;  1WI1 A;  3WYF B;  2E2X A;  3SYX A;  1X1F A;  1Z87 A;  3P7Z A;  2EJ8 A;  2Z13 A;  1V5U A;  4F7U P;  1MIZ B;  2LYD A;  1WG7 A;  4D6W A;  1ZC4 B;  1KI1 B;  4GPT B;  2COA A;  1BTN A;  4OT1 A;  3AJ4 A;  2ZKM X;  5EFX A;  1X1G A;  3HQC A;  1SGH A;  4EMO A;  2N23 A;  4HB3 B;  5D3V A;  3A58 A;  4HDQ A;  2YT2 A;  3NW8 A;  1ISN A;  3P6A A;  2YS3 A;  1DRO A;  1GC7 A;  3PVU A;  1QQG A;  2LOZ A;  1ZVR A;  2D9Y A;  1DDV A;  2RGN B;  4OSN A;  5FI1 A;  4KHO A;  1K5D B;  2RLO A;  4L1R A;  1I2H A;  2MDX A;  3KY9 A;  5KCV A;  1DBH A;  1P5T A;  2XQN M;  1P3R A;  4EKU A;  2KIE A;  2N0Y A;  5CLL B;  1LB1 A;  2DLW A;  2J59 M;  1H10 A;  3WA0 A;  3TFM A;  3M1I B;  5D3W A;  4BBK A;  2MWN B;  2R09 A;  5D3X A;  4TKN A;  3TW1 A;  1U29 A;  4IOY X;  5GOW B;  4HAY B;  4MK0 A;  2UVM A;  1H4R A;  2DYN A;  2NZ8 B;  1BWN A;  2V76 A;  1X86 A;  5C79 A;  2LG1 A;  4K17 A;  3V5W A;  4WJ7 A;  1FGY A;  2D9X A;  4WSF A;  1V88 A;  1UNP A;  3PZD A;  3DXE A;  1M7R A;  4PQ0 A;  5C5B B;  2DHJ A;  2ADZ A;  5KQ4 A;  2BCJ A;  2ELA A;  4HAX B;  2DHK A;  4Y94 A;  2KGX B;  3D8F A;  4HAT B;  2M14 A;  3PEG A;  1FHX A;  1DDW A;  1IRS A;  2W2X D;  4DBB A;  5I2M A;  1PFJ A;  2QKL A;  3D8D A;  3FEH A;  2J0M A;  3AU5 A;  2DKQ A;  1AQC A;  5DHF B;  1J0W A;  4HAV B;  3QIJ A;  1NI2 A;  1OY2 A;  3U12 A;  2ZPY A;  1X05 A;  3A8P A;  2I5C A;  5LOP B;  1QC6 A;  4HAW B;  2YS1 A;  3ULC A;  4DXA B;  3ODX A;  2D4Q A;  2FJL A;  2UZR A;  1XCG A;  3NSU A;  2GCL A;  1ZSQ A;  2D10 A;  4YON A;  4HAU B;  2P0F A;  2AL6 A;  2LOX A;  4GOU A;  2I1K A;  4KAX B;  1MIX A;  2KUQ A;  1V89 A;  2RUK B;  2DX1 A;  1U5D A;  1MK9 B;  1E5W A;  5DHA B;  2COC A;  2KIG A;  3T06 A;  1W1H A;  3KSY A;  2CY5 A;  4K2O A;  1TQZ A;  4XWX A;  2Y7B A;  4C0A A;  5I2S A;  3IVF A;  2D11 A;  4A6H A;  1AWE A;  2Z0P A;  3ZVR A;  5HE3 A;  4QJ5 B;  2Q13 A;  3BJI A;  1UNR A;  2VKI A;  2DX5 A;  4PNK A;  2Z14 A;  2PZ1 A;  2JP2 A;  3ULB A;  3SUZ A;  2L1C A;  3F5R A;  3FVC A;  1WVH A;  1LW3 A;  1U5F A;  4HHV A;  2VRW B;  1PLS A;  2D9Z A;  3BIN A;  1V5M A;  1UPR A;  4YL8 A;  3ML4 A;  3HW2 B;  1N3H A;  1MPH A;  1EF1 A;  3TVV A;  2YF0 A;  1NU2 A;  2P0H A;  2NMB A;  2EC1 A;  1V5P A;  5IRS A;  2H7D A;  3NWF A;  3U8Z A; 
#chains in the Genus database with same CATH homology
 2YT2 A;  4QJ5 B;  4KHB A;  2KUQ A;  3NW8 A;  2KR0 A;  3FSS A;  4PQ0 A;  4KHA A;  4CSQ A;  4KHB B;  2Z14 A;  3TW1 A;  2FJU B;  3U12 A;  1ZYI A;  2KIG A;  4IOY X;  2Z13 A;  4Z2M B;  4GNK B;  3TO1 A;  3FVC A;  4D6W A;  4OSN A;  3NWD A;  2R2Y A;  4KHO A;  5M4Y B;  2K8E A;  4DIX A;  3OHM B;  3NWA A;  4IFS A;  2K49 A;  4L1R A;  4QXA B;  5I2M A;  2RRF A;  2GCL A;  2Z4D A;  4HSI A;  4OT1 A;  4QJ3 B;  5I2S A;  2ZKM X;  3GYP A;  2Z59 A;  3HIE A;  3NWF A;  3GYO A;  3TVV A;  2KIE A;  2GCJ A;  2NBV A;  5IRS A;  4Z2N A;  5LG4 B;  3A58 A;  2GUM A;  4GOU A;  4QJ4 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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