4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
source organism Human herpesvirus 1
molecule tags Viral protein
molecule keywords Envelope glycoprotein B
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
4L1RA 2GUMA 3NWDA 3FVCA 4OSNA 4OT1A 3NWAA 3NW8A 4HSIA 3NWFA
chains in the Genus database with same CATH superfamily
2HTHB 1WJMA 4Z2NA 2K49A 3U8ZA 4HB4B 2Y8GA 1U5GA 1XD4A 1W1DA 3ML4A 1ISNA 5J3QA 1JTGB 3GMUB 1UEFA 3FEHA 1X05A 1ZYIA 1AQCA 2RVBB 4GNKB 3FVCA 2PZ1A 1H4RA 4TKNA 1K5GB 1DDMA 1V89A 2DN6A 2EC1A 1WGUA 1TQZA 1DDWA 1I2HA 2LOXA 2GS0A 1WGQA 1PMSA 2NMBA 4BBKA 5C6RA 2D9WA 5IRSA 2N0YA 2D11A 2YS1A 4WJ7A 2MKRA 1WG7A 2AEHA 3AU4A 1XXMC 2D9XA 3PEGA 2KCJA 1W1HA 2DTCA 4XWXA 1NU2A 5CLLB 2G35A 5DH9B 2CRFA 5FI0A 5D3YA 1ZC4B 3BJIA 4MT7A 5D3WA 1X1FA 3G9WA 2I1KA 1U5DA 2KGXB 2VSZA 2V76A 1DDVA 4TYZA 4D6WA 3ODWA 3D4EA 4DBBA 4IAPA 3U7DA 4HAXB 2DX5A 2YVCA 3OANA 4KHOA 1S0WC 1EAZA 1ZSQA 2FJUB 2COCA 4CHJA 3PVUA 2CY5A 4A6FA 3A8PA 5D3XA 2I5CA 2DA0A 1OMWA 3FSSA 4HDOA 3D8DA 5DIFB 2Q13A 1OY2A 2Z0PA 2Z14A 2P0HA 4HAUB 1T77A 2DFKA 2W2WA 1V61A 3DXCA 1M7EA 4NSWA 5D27A 4DX8A 4CHMA 4OT1A 4HAWB 3AU5A 4GMVA 2CODA 5KQ4A 2K00A 1MKEA 3ULBA 1J0WA 4KAXB 4HATB 5JHGA 1MI1A 4A6KA 4C0AA 1BTKA 2RNRB 3A8QA 3SV1A 1U27A 4YONA 1FHWA 2YT2A 2Y8FA 4QJ4B 5C5BB 3KY9A 3N4IB 5L81A 1UNQA 1Z87A 2I5FA 3NWDA 5EKQE 4GMXB 3HK0A 4QJ5B 1P6SA 1BWNA 3GYPA 2Z0QA 4KHAA 2G2UB 4ZRKA 1B55A 2H7DA 2Z4DA 3D8EA 5KCVA 1LW3A 3KRXA 1GG3A 2D10A 2QKLA 1EF1A 2EMTA 2YRYA 2R2YA 1N3HA 4L6EA 2D9ZA 2OTXA 3A58A 2P8VA 3D8FA 3DXDA 3C7VB 1U2BA 2DYNA 5JHHA 2J59M 2RUKB 1DYNA 1U5FA 1PFJA 4EJNA 1KI1B 1KZGA 3RCPA 2W2XC 3C4OB 2LYDA 3KRWA 1MAIA 3E2KC 5I2MA 3SYXA 2GJYA 1XODA 1V5MA 1XR0B 2ELAA 4GZUA 5C79A 2NBVA 2L2IA 2ZPYA 3ULCA 4QXAB 1GC6A 1EVHA 3QBVB 3UZTA 1RJ2A 1DBHA 3TFMA 2ROZB 5HE1A 3PZDA 2GUMA 1WVHA 4IOYX 4GPTB 1MIZB 2OQBA 3ODOA 3PVLA 2QKMA 1V5PA 2P0FA 4L1RA 2D2QA 1DROA 2I1JA 1W1GA 2X18A 4KHBA 2Z13A 3M1IB 2IYBA 1E5WA 1MPHA 5C16A 1UNPA 1KZ7A 5LONB 1I7AA 4HDQA 3WA0A 2CY4A 5FI1A 4K81A 3QIJA 2EJ8A 3PG7A 5HE3A 3C7UB 2YH9A 2YSZA 2P0DA 3KSYA 3P7ZA 3A98B 3HSAA 1X86A 5EFXA 1QQGA 3T06A 2Z0OA 1U29A 3QWMA 1Y19B 4Y94A 2RRFA 1IRSA 2D9YA 4OSNA 4CYEA 1FHXA 3TVVA 5CLQB 4MK0A 4K17A 5LG4B 1UPQA 2J0KA 4IFSA 4YL8A 3IVFA 1RRPB 3F5RA 2DLWA 3ODXA 2KUQA 5D0OE 4KVGB 2LKOA 3KZ1A 1WI1A 2Y7BA 3O96A 3P6AA 2H7EA 2R0DA 2VKIA 4B6HA 3NWFA 5JP4A 1FB8A 4ZRJA 1X11A 4F7UP 2COFA 2L1CA 2AL6A 3TW1A 2CAYA 4ZRIA 5M4YB 5GOWB 2GCLA 2FJLA 2KIGA 4EMOA 2ROVA 4K2OA 3HQCA 1P3RA 1FHOA 2RSGA 1Q67A 4HAVB 4P7IA 2K2JA 5HE0A 3SNHA 4DXAB 2DHJA 1U5EA 1ZVRA 1ZM0A 3HIEA 1BTNA 4QJ3B 3CXBB 3MPXA 3NW8A 3HW2B 3WYFB 4HB2B 4HAYB 3B77A 2J0MA 2LG1A 3CIKA 2N23A 3AJ4A 2COAA 2XQNM 1H10A 4CSQA 5DHFB 2UVMA 2DKQA 1P5TA 3DXEA 2YS5A 3LJUX 3PSCA 2IFSA 2W2XD 3MDBC 3X23A 4DIXA 3FM8C 5C5BA 2YT1A 1X1GA 4NY0A 3U12A 4KHBB 1EGXA 5J3TA 4DX90 1MK7B 3TO1A 2PXGA 2MDXA 4GN1A 2B5RC 3F0WA 2ADZA 2DX1A 3NSUA 2LOZA 3OHMB 2JP2A 2MFQA 2VRWB 5DI9B 5D0QE 4A5KA 3VOQA 2DYQA 1PLSA 5JLJB 2KUPA 1TXDA 3PP2A 2GCJA 4Z2MB 5D3VA 2R09A 1MIXA 2DHIA 3ZDTA 2HE7A 3ZVRA 1AWEA 3BINA 1FOEA 4GXBA 2RLOA 2UZRA 3SUZA 2DKPA 1XKEA 2NZ8B 1GC7A 1ZC3B 2MWNB 1FAOA 3E2LC 4HB0B 1LB1A 2D4QA 4DM5A 2DHKA 3V5WA 3TCAA 2Z59A 1NTYA 4HHVA 3C4PB 1FGZA 2KXXA 2KM7A 1UNRA 5AYWE 4PNKA 2BCJA 5DHAB 4HSIA 2M38A 4A6HA 4K2PA 2E2XA 1QC6A 5HE2A 4GOUA 1OQNA 1V5UA 2RGNB 3SO6A 5KQ1A 3VIAA 3GYOA 4EKUA 2ELBA 1NTVA 4MY6A 2D9VA 2KR0A 2YS3A 1MK9B 2M14A 2K8EA 2YT0A 1V88A 4WVFB 1XX0A 4HAZB 4A6FB 3N7CA 2G2WB 1UPRA 2LULA 3DCXA 1K5DB 1SGHA 2KIEA 1WJ1A 1J19A 2J0JA 2UZSA 4F7HA 2K2UA 1TJ6A 4D0NB 1FGYA 4F7GA 4H8SA 5LOPB 1BAKA 2YF0A 1NI2A 1Y5OA 4WSFA 2ZKMX 1M7RA 1SHCA 2EMSA 1XCGA 3PVWA 5I2SA 3NWAA 5J3YA 4PQ0A 4HB3B
chains in the Genus database with same CATH topology
3U12A 4KHBA 2Z13A 4Z2NA 4KHBB 2K49A 3TO1A 2PXGA 2B5RC 1JTGB 3GMUB 3C7UB 2YH9A 1ZYIA 3OHMB 4GNKB 2YT2A 3FVCA 5D0QE 4QJ4B 3N4IB 4Z2MB 2GCJA 3NWDA 5EKQE 2RRFA 4OSNA 3TVVA 4QJ5B 3GYPA 4KHAA 5LG4B 2G2UB 2Z4DA 4IFSA 5IRSA 2R2YA 2KUQA 5D0OE 3E2LC 3A58A 1XXMC 3C7VB 4DM5A 3NWFA 2Z59A 3C4PB 2KXXA 2KM7A 5AYWE 3TW1A 4HSIA 5M4YB 3C4OB 2GCLA 5I2MA 3E2KC 2KIGA 4GOUA 4D6WA 2NBVA 3D4EA 3GYOA 4KHOA 4QXAB 2KR0A 1S0WC 2K8EA 2FJUB 3HIEA 2G2WB 4QJ3B 3NW8A 3FSSA 2GUMA 2KIEA 2Z14A 4IOYX 4CSQA 2ZKMX 4L1RA 4OT1A 4DIXA 5I2SA 3NWAA 4PQ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L1R A;  2GUM A;  3NWD A;  3FVC A;  4OSN A;  4OT1 A;  3NWA A;  3NW8 A;  4HSI A;  3NWF A; 
#chains in the Genus database with same CATH topology
 2HTH B;  1WJM A;  4Z2N A;  2K49 A;  3U8Z A;  4HB4 B;  2Y8G A;  1U5G A;  1XD4 A;  1W1D A;  3ML4 A;  1ISN A;  5J3Q A;  1JTG B;  3GMU B;  1UEF A;  3FEH A;  1X05 A;  1ZYI A;  1AQC A;  2RVB B;  4GNK B;  3FVC A;  2PZ1 A;  1H4R A;  4TKN A;  1K5G B;  1DDM A;  1V89 A;  2DN6 A;  2EC1 A;  1WGU A;  1TQZ A;  1DDW A;  1I2H A;  2LOX A;  2GS0 A;  1WGQ A;  1PMS A;  2NMB A;  4BBK A;  5C6R A;  2D9W A;  5IRS A;  2N0Y A;  2D11 A;  2YS1 A;  4WJ7 A;  2MKR A;  1WG7 A;  2AEH A;  3AU4 A;  1XXM C;  2D9X A;  3PEG A;  2KCJ A;  1W1H A;  2DTC A;  4XWX A;  1NU2 A;  5CLL B;  2G35 A;  5DH9 B;  2CRF A;  5FI0 A;  5D3Y A;  1ZC4 B;  3BJI A;  4MT7 A;  5D3W A;  1X1F A;  3G9W A;  2I1K A;  1U5D A;  2KGX B;  2VSZ A;  2V76 A;  1DDV A;  4TYZ A;  4D6W A;  3ODW A;  3D4E A;  4DBB A;  4IAP A;  3U7D A;  4HAX B;  2DX5 A;  2YVC A;  3OAN A;  4KHO A;  1S0W C;  1EAZ A;  1ZSQ A;  2FJU B;  2COC A;  4CHJ A;  3PVU A;  2CY5 A;  4A6F A;  3A8P A;  5D3X A;  2I5C A;  2DA0 A;  1OMW A;  3FSS A;  4HDO A;  3D8D A;  5DIF B;  2Q13 A;  1OY2 A;  2Z0P A;  2Z14 A;  2P0H A;  4HAU B;  1T77 A;  2DFK A;  2W2W A;  1V61 A;  3DXC A;  1M7E A;  4NSW A;  5D27 A;  4DX8 A;  4CHM A;  4OT1 A;  4HAW B;  3AU5 A;  4GMV A;  2COD A;  5KQ4 A;  2K00 A;  1MKE A;  3ULB A;  1J0W A;  4KAX B;  4HAT B;  5JHG A;  1MI1 A;  4A6K A;  4C0A A;  1BTK A;  2RNR B;  3A8Q A;  3SV1 A;  1U27 A;  4YON A;  1FHW A;  2YT2 A;  2Y8F A;  4QJ4 B;  5C5B B;  3KY9 A;  3N4I B;  5L81 A;  1UNQ A;  1Z87 A;  2I5F A;  3NWD A;  5EKQ E;  4GMX B;  3HK0 A;  4QJ5 B;  1P6S A;  1BWN A;  3GYP A;  2Z0Q A;  4KHA A;  2G2U B;  4ZRK A;  1B55 A;  2H7D A;  2Z4D A;  3D8E A;  5KCV A;  1LW3 A;  3KRX A;  1GG3 A;  2D10 A;  2QKL A;  1EF1 A;  2EMT A;  2YRY A;  2R2Y A;  1N3H A;  4L6E A;  2D9Z A;  2OTX A;  3A58 A;  2P8V A;  3D8F A;  3DXD A;  3C7V B;  1U2B A;  2DYN A;  5JHH A;  2J59 M;  2RUK B;  1DYN A;  1U5F A;  1PFJ A;  4EJN A;  1KI1 B;  1KZG A;  3RCP A;  2W2X C;  3C4O B;  2LYD A;  3KRW A;  1MAI A;  3E2K C;  5I2M A;  3SYX A;  2GJY A;  1XOD A;  1V5M A;  1XR0 B;  2ELA A;  4GZU A;  5C79 A;  2NBV A;  2L2I A;  2ZPY A;  3ULC A;  4QXA B;  1GC6 A;  1EVH A;  3QBV B;  3UZT A;  1RJ2 A;  1DBH A;  3TFM A;  2ROZ B;  5HE1 A;  3PZD A;  2GUM A;  1WVH A;  4IOY X;  4GPT B;  1MIZ B;  2OQB A;  3ODO A;  3PVL A;  2QKM A;  1V5P A;  2P0F A;  4L1R A;  2D2Q A;  1DRO A;  2I1J A;  1W1G A;  2X18 A;  4KHB A;  2Z13 A;  3M1I B;  2IYB A;  1E5W A;  1MPH A;  5C16 A;  1UNP A;  1KZ7 A;  5LON B;  1I7A A;  4HDQ A;  3WA0 A;  2CY4 A;  5FI1 A;  4K81 A;  3QIJ A;  2EJ8 A;  3PG7 A;  5HE3 A;  3C7U B;  2YH9 A;  2YSZ A;  2P0D A;  3KSY A;  3P7Z A;  3A98 B;  3HSA A;  1X86 A;  5EFX A;  1QQG A;  3T06 A;  2Z0O A;  1U29 A;  3QWM A;  1Y19 B;  4Y94 A;  2RRF A;  1IRS A;  2D9Y A;  4OSN A;  4CYE A;  1FHX A;  3TVV A;  5CLQ B;  4MK0 A;  4K17 A;  5LG4 B;  1UPQ A;  2J0K A;  4IFS A;  4YL8 A;  3IVF A;  1RRP B;  3F5R A;  2DLW A;  3ODX A;  2KUQ A;  5D0O E;  4KVG B;  2LKO A;  3KZ1 A;  1WI1 A;  2Y7B A;  3O96 A;  3P6A A;  2H7E A;  2R0D A;  2VKI A;  4B6H A;  3NWF A;  5JP4 A;  1FB8 A;  4ZRJ A;  1X11 A;  4F7U P;  2COF A;  2L1C A;  2AL6 A;  3TW1 A;  2CAY A;  4ZRI A;  5M4Y B;  5GOW B;  2GCL A;  2FJL A;  2KIG A;  4EMO A;  2ROV A;  4K2O A;  3HQC A;  1P3R A;  1FHO A;  2RSG A;  1Q67 A;  4HAV B;  4P7I A;  2K2J A;  5HE0 A;  3SNH A;  4DXA B;  2DHJ A;  1U5E A;  1ZVR A;  1ZM0 A;  3HIE A;  1BTN A;  4QJ3 B;  3CXB B;  3MPX A;  3NW8 A;  3HW2 B;  3WYF B;  4HB2 B;  4HAY B;  3B77 A;  2J0M A;  2LG1 A;  3CIK A;  2N23 A;  3AJ4 A;  2COA A;  2XQN M;  1H10 A;  4CSQ A;  5DHF B;  2UVM A;  2DKQ A;  1P5T A;  3DXE A;  2YS5 A;  3LJU X;  3PSC A;  2IFS A;  2W2X D;  3MDB C;  3X23 A;  4DIX A;  3FM8 C;  5C5B A;  2YT1 A;  1X1G A;  4NY0 A;  3U12 A;  4KHB B;  1EGX A;  5J3T A;  4DX9 0;  1MK7 B;  3TO1 A;  2PXG A;  2MDX A;  4GN1 A;  2B5R C;  3F0W A;  2ADZ A;  2DX1 A;  3NSU A;  2LOZ A;  3OHM B;  2JP2 A;  2MFQ A;  2VRW B;  5DI9 B;  5D0Q E;  4A5K A;  3VOQ A;  2DYQ A;  1PLS A;  5JLJ B;  2KUP A;  1TXD A;  3PP2 A;  2GCJ A;  4Z2M B;  5D3V A;  2R09 A;  1MIX A;  2DHI A;  3ZDT A;  2HE7 A;  3ZVR A;  1AWE A;  3BIN A;  1FOE A;  4GXB A;  2RLO A;  2UZR A;  3SUZ A;  2DKP A;  1XKE A;  2NZ8 B;  1GC7 A;  1ZC3 B;  2MWN B;  1FAO A;  3E2L C;  4HB0 B;  1LB1 A;  2D4Q A;  4DM5 A;  2DHK A;  3V5W A;  3TCA A;  2Z59 A;  1NTY A;  4HHV A;  3C4P B;  1FGZ A;  2KXX A;  2KM7 A;  1UNR A;  5AYW E;  4PNK A;  2BCJ A;  5DHA B;  4HSI A;  2M38 A;  4A6H A;  4K2P A;  2E2X A;  1QC6 A;  5HE2 A;  4GOU A;  1OQN A;  1V5U A;  2RGN B;  3SO6 A;  5KQ1 A;  3VIA A;  3GYO A;  4EKU A;  2ELB A;  1NTV A;  4MY6 A;  2D9V A;  2KR0 A;  2YS3 A;  1MK9 B;  2M14 A;  2K8E A;  2YT0 A;  1V88 A;  4WVF B;  1XX0 A;  4HAZ B;  4A6F B;  3N7C A;  2G2W B;  1UPR A;  2LUL A;  3DCX A;  1K5D B;  1SGH A;  2KIE A;  1WJ1 A;  1J19 A;  2J0J A;  2UZS A;  4F7H A;  2K2U A;  1TJ6 A;  4D0N B;  1FGY A;  4F7G A;  4H8S A;  5LOP B;  1BAK A;  2YF0 A;  1NI2 A;  1Y5O A;  4WSF A;  2ZKM X;  1M7R A;  1SHC A;  2EMS A;  1XCG A;  3PVW A;  5I2S A;  3NWA A;  5J3Y A;  4PQ0 A;  4HB3 B; 
#chains in the Genus database with same CATH homology
 3U12 A;  4KHB A;  2Z13 A;  4Z2N A;  4KHB B;  2K49 A;  3TO1 A;  2PXG A;  2B5R C;  1JTG B;  3GMU B;  3C7U B;  2YH9 A;  1ZYI A;  3OHM B;  4GNK B;  2YT2 A;  3FVC A;  5D0Q E;  4QJ4 B;  3N4I B;  4Z2M B;  2GCJ A;  3NWD A;  5EKQ E;  2RRF A;  4OSN A;  3TVV A;  4QJ5 B;  3GYP A;  4KHA A;  5LG4 B;  2G2U B;  2Z4D A;  4IFS A;  5IRS A;  2R2Y A;  2KUQ A;  5D0O E;  3E2L C;  3A58 A;  1XXM C;  3C7V B;  4DM5 A;  3NWF A;  2Z59 A;  3C4P B;  2KXX A;  2KM7 A;  5AYW E;  3TW1 A;  4HSI A;  5M4Y B;  3C4O B;  2GCL A;  5I2M A;  3E2K C;  2KIG A;  4GOU A;  4D6W A;  2NBV A;  3D4E A;  3GYO A;  4KHO A;  4QXA B;  2KR0 A;  1S0W C;  2K8E A;  2FJU B;  3HIE A;  2G2W B;  4QJ3 B;  3NW8 A;  3FSS A;  2GUM A;  2KIE A;  2Z14 A;  4IOY X;  4CSQ A;  2ZKM X;  4L1R A;  4OT1 A;  4DIX A;  5I2S A;  3NWA A;  4PQ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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