4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Envelope glycoprotein B
publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
source organism Human herpesvirus 1
molecule tags Viral protein
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
3NW8A 3NWAA 4OSNA 4OT1A 4HSIA 3NWDA 2GUMA 4L1RA 3FVCA 3NWFA
chains in the Genus database with same CATH superfamily
1J19A 2YT1A 2LULA 1Q67A 1GG3A 3IVFA 5LONB 2P0DA 1M7EA 4WVFB 5DI9B 3U7DA 2KXXA 4HHVA 5J3YA 1V61A 1WG7A 4L1RA 2K00A 1U5GA 1FGZA 2D9VA 1BAKA 2LKOA 2KM7A 2GUMA 3N4IB 5C5BA 1FOEA 1OMWA 2UZRA 1UEFA 1U2BA 1DDWA 2MKRA 1P5TA 2M14A 2KGXB 3D8DA 1ZM0A 3F0WA 1Y5OA 1EGXA 1KZ7A 1AQCA 3SO6A 2EMSA 2IYBA 3MDBC 3X23A 3A58A 1P6SA 4IAPA 1U29A 2CY4A 5IRSA 1FAOA 4ZRJA 2K2JA 3KSYA 1ZVRA 1PMSA 5DHAB 4KHOA 3UZTA 2R09A 5CLQB 5C5BB 4DX8A 2W2XC 2MWNB 1XKEA 5AYWE 3PZDA 1U5FA 2KUQA 1BTNA 2QKMA 1ZYIA 3D8FA 1DROA 1X1FA 1SHCA 1EAZA 2LOZA 1V88A 1RRPB 5I2SA 5HE1A 2FJLA 1FHXA 2UVMA 1UNRA 3CXBB 4HAUB 2B5RC 2DN6A 5D0QE 2M38A 5D27A 2IFSA 1WJMA 4K2OA 2MDXA 4HAZB 2R2YA 2CRFA 2YS3A 1UNQA 2MFQA 1Y19B 2J0MA 4HAYB 3VIAA 1EVHA 4A6FB 1FB8A 2NMBA 4KHBB 1PLSA 1UNPA 5JLJB 3RCPA 1XX0A 2K49A 4HDOA 4A6KA 3QWMA 4EKUA 2G2WB 3PEGA 1NU2A 1Z87A 3TVVA 2KIGA 1TXDA 2KR0A 4HAXB 4PQ0A 2Z13A 4A6HA 1ISNA 2DYNA 2Y8FA 1TQZA 1OY2A 4MK0A 3G9WA 3U12A 1X11A 1ZC3B 1DYNA 5FI0A 1IRSA 4H8SA 4QXAB 4GXBA 3SV1A 3HW2B 1GC6A 2Y8GA 4GZUA 4F7GA 5KQ4A 4BBKA 2L2IA 3WYFB 2DX1A 2PZ1A 2DTCA 2P0FA 4F7UP 4YL8A 1ZC4B 2NZ8B 3LJUX 3WA0A 3HQCA 1NI2A 2Z0OA 3ZVRA 1S0WC 5DIFB 3ULCA 1MAIA 4NSWA 4GPTB 2COFA 5HE3A 2FJUB 2RSGA 2ZKMX 2W2WA 1BWNA 4CHMA 2YT0A 1X05A 1U5DA 3OHMB 2R0DA 3PVLA 1X1GA 4MT7A 4F7HA 3FSSA 1EF1A 4DIXA 2Z59A 2E2XA 3PSCA 5JHGA 1FHOA 3PVUA 3FEHA 4CSQA 4GMVA 4HAWB 3GYPA 1QQGA 1M7RA 2D9WA 2D2QA 2ELAA 2D10A 3DCXA 3ZDTA 3O96A 3D8EA 1XODA 4GNKB 2YF0A 2D9XA 2W2XD 4TYZA 3ODWA 1UPQA 2D11A 2Z4DA 4HB4B 3PG7A 1SGHA 2PXGA 1V89A 2YS1A 2Z0PA 1LB1A 3TW1A 2DFKA 2KUPA 2KIEA 5D3YA 4KHAA 4WJ7A 4K2PA 1I2HA 4YONA 3F5RA 4WSFA 2RGNB 2RVBB 3FVCA 4GN1A 2H7EA 2NBVA 2DKPA 4Z2NA 4QJ4B 4QJ3B 4EMOA 5HE0A 2GS0A 2YVCA 2I5FA 2CAYA 3A8QA 2DX5A 3DXCA 3BJIA 5D3WA 2OTXA 3VOQA 1BTKA 1WJ1A 2CY5A 1MKEA 3N7CA 3HSAA 5LOPB 2DA0A 1V5PA 1XCGA 2OQBA 2RLOA 4P7IA 3TO1A 2LYDA 2VRWB 2YSZA 3C4PB 1V5UA 1U5EA 1GC7A 3NWAA 2I1KA 5KQ1A 1DDVA 1LW3A 3P6AA 2P0HA 2X18A 2COCA 3U8ZA 1MI1A 2D9YA 2KCJA 1KI1B 3SYXA 3PP2A 3GMUB 2Z14A 3B77A 4PNKA 2DYQA 2AEHA 5C16A 1NTYA 1AWEA 3A8PA 3NWFA 3C4OB 4OSNA 2HTHB 1JTGB 1H4RA 1B55A 4A5KA 4D6WA 2RNRB 5JHHA 2H7DA 4IFSA 1MPHA 3KY9A 2DLWA 4DM5A 2HE7A 1WVHA 3E2LC 1FGYA 1TJ6A 2ROZB 4GOUA 2N23A 3OANA 4KAXB 5FI1A 4IOYX 3V5WA 4EJNA 1UPRA 5DHFB 2DHIA 3NW8A 3QIJA 3D4EA 4GMXB 1KZGA 2Y7BA 4K17A 3AU5A 2XQNM 1NTVA 3ML4A 5D3VA 1DBHA 1WGUA 3M1IB 1XR0B 2RRFA 1J0WA 1OQNA 2I1JA 3KRWA 4HB0B 4KVGB 4Z2MB 1V5MA 4HB2B 1K5GB 2LG1A 4D0NB 3C7VB 2DKQA 3KZ1A 2YRYA 4CHJA 2G2UB 2COAA 2ADZA 3PVWA 3T06A 5KCVA 2J59M 4MY6A 1K5DB 4TKNA 5J3TA 1W1HA 2Q13A 2JP2A 2YT2A 3SUZA 1RJ2A 4HATB 5C6RA 2GJYA 2QKLA 3DXDA 5CLLB 3BINA 2Z0QA 2ROVA 3KRXA 2J0JA 4Y94A 3ODXA 3HIEA 5L81A 4A6FA 4HB3B 5J3QA 4KHBA 2V76A 2LOXA 4C0AA 4QJ5B 4XWXA 2L1CA 2UZSA 1MIXA 1WGQA 2D9ZA 3A98B 1MIZB 1ZSQA 2EJ8A 3MPXA 2VKIA 2AL6A 3GYOA 4L6EA 2YH9A 2EC1A 4HDQA 5EKQE 2VSZA 1N3HA 1PFJA 2I5CA 2GCLA 3NSUA 5M4YB 5D0OE 2K8EA 3QBVB 4HSIA 1WI1A 3ODOA 1P3RA 4CYEA 4K81A 5D3XA 4DX90 2ELBA 4ZRKA 3P7ZA 2P8VA 2ZPYA 5LG4B 5GOWB 1I7AA 5HE2A 2DHKA 2BCJA 2GCJA 4HAVB 3AU4A 5I2MA 2YS5A 3SNHA 5EFXA 3DXEA 2K2UA 5C79A 1W1DA 2CODA 1FHWA 3HK0A 2D4QA 4DBBA 3ULBA 1U27A 1MK9B 1XD4A 2RUKB 4NY0A 1T77A 3AJ4A 4B6HA 2EMTA 1W1GA 4ZRIA 5DH9B 1DDMA 3C7UB 1X86A 2G35A 2N0YA 3FM8C 3TCAA 3NWDA 1XXMC 1QC6A 2DHJA 1MK7B 3TFMA 4OT1A 5JP4A 2J0KA 1E5WA 1H10A 4DXAB 3E2KC 3CIKA
chains in the Genus database with same CATH topology
2Z13A 2KXXA 4L1RA 2YT2A 3U12A 2KM7A 2GUMA 3N4IB 3TO1A 4QXAB 3C4PB 3NWAA 3HIEA 4KHBA 4QJ5B 3A58A 5IRSA 3GYOA 3GMUB 2YH9A 2Z14A 4KHOA 5EKQE 1S0WC 5M4YB 3NWFA 2GCLA 5D0OE 3C4OB 4OSNA 5AYWE 2FJUB 2K8EA 1JTGB 4HSIA 2ZKMX 2KUQA 4D6WA 3OHMB 1ZYIA 3FSSA 4IFSA 4DIXA 5LG4B 2Z59A 5I2SA 4CSQA 4DM5A 2GCJA 3GYPA 3E2LC 5I2MA 2B5RC 4GOUA 5D0QE 4GNKB 4IOYX 2R2YA 2Z4DA 3NW8A 3D4EA 2PXGA 3TW1A 2KIEA 4KHBB 4KHAA 3C7UB 2RRFA 3FVCA 2K49A 2NBVA 4Z2MB 4Z2NA 4QJ4B 2G2WB 4QJ3B 3NWDA 1XXMC 3C7VB 3TVVA 4OT1A 2KIGA 2KR0A 3E2KC 4PQ0A 2G2UB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NW8 A;  3NWA A;  4OSN A;  4OT1 A;  4HSI A;  3NWD A;  2GUM A;  4L1R A;  3FVC A;  3NWF A; 
#chains in the Genus database with same CATH topology
 1J19 A;  2YT1 A;  2LUL A;  1Q67 A;  1GG3 A;  3IVF A;  5LON B;  2P0D A;  1M7E A;  4WVF B;  5DI9 B;  3U7D A;  2KXX A;  4HHV A;  5J3Y A;  1V61 A;  1WG7 A;  4L1R A;  2K00 A;  1U5G A;  1FGZ A;  2D9V A;  1BAK A;  2LKO A;  2KM7 A;  2GUM A;  3N4I B;  5C5B A;  1FOE A;  1OMW A;  2UZR A;  1UEF A;  1U2B A;  1DDW A;  2MKR A;  1P5T A;  2M14 A;  2KGX B;  3D8D A;  1ZM0 A;  3F0W A;  1Y5O A;  1EGX A;  1KZ7 A;  1AQC A;  3SO6 A;  2EMS A;  2IYB A;  3MDB C;  3X23 A;  3A58 A;  1P6S A;  4IAP A;  1U29 A;  2CY4 A;  5IRS A;  1FAO A;  4ZRJ A;  2K2J A;  3KSY A;  1ZVR A;  1PMS A;  5DHA B;  4KHO A;  3UZT A;  2R09 A;  5CLQ B;  5C5B B;  4DX8 A;  2W2X C;  2MWN B;  1XKE A;  5AYW E;  3PZD A;  1U5F A;  2KUQ A;  1BTN A;  2QKM A;  1ZYI A;  3D8F A;  1DRO A;  1X1F A;  1SHC A;  1EAZ A;  2LOZ A;  1V88 A;  1RRP B;  5I2S A;  5HE1 A;  2FJL A;  1FHX A;  2UVM A;  1UNR A;  3CXB B;  4HAU B;  2B5R C;  2DN6 A;  5D0Q E;  2M38 A;  5D27 A;  2IFS A;  1WJM A;  4K2O A;  2MDX A;  4HAZ B;  2R2Y A;  2CRF A;  2YS3 A;  1UNQ A;  2MFQ A;  1Y19 B;  2J0M A;  4HAY B;  3VIA A;  1EVH A;  4A6F B;  1FB8 A;  2NMB A;  4KHB B;  1PLS A;  1UNP A;  5JLJ B;  3RCP A;  1XX0 A;  2K49 A;  4HDO A;  4A6K A;  3QWM A;  4EKU A;  2G2W B;  3PEG A;  1NU2 A;  1Z87 A;  3TVV A;  2KIG A;  1TXD A;  2KR0 A;  4HAX B;  4PQ0 A;  2Z13 A;  4A6H A;  1ISN A;  2DYN A;  2Y8F A;  1TQZ A;  1OY2 A;  4MK0 A;  3G9W A;  3U12 A;  1X11 A;  1ZC3 B;  1DYN A;  5FI0 A;  1IRS A;  4H8S A;  4QXA B;  4GXB A;  3SV1 A;  3HW2 B;  1GC6 A;  2Y8G A;  4GZU A;  4F7G A;  5KQ4 A;  4BBK A;  2L2I A;  3WYF B;  2DX1 A;  2PZ1 A;  2DTC A;  2P0F A;  4F7U P;  4YL8 A;  1ZC4 B;  2NZ8 B;  3LJU X;  3WA0 A;  3HQC A;  1NI2 A;  2Z0O A;  3ZVR A;  1S0W C;  5DIF B;  3ULC A;  1MAI A;  4NSW A;  4GPT B;  2COF A;  5HE3 A;  2FJU B;  2RSG A;  2ZKM X;  2W2W A;  1BWN A;  4CHM A;  2YT0 A;  1X05 A;  1U5D A;  3OHM B;  2R0D A;  3PVL A;  1X1G A;  4MT7 A;  4F7H A;  3FSS A;  1EF1 A;  4DIX A;  2Z59 A;  2E2X A;  3PSC A;  5JHG A;  1FHO A;  3PVU A;  3FEH A;  4CSQ A;  4GMV A;  4HAW B;  3GYP A;  1QQG A;  1M7R A;  2D9W A;  2D2Q A;  2ELA A;  2D10 A;  3DCX A;  3ZDT A;  3O96 A;  3D8E A;  1XOD A;  4GNK B;  2YF0 A;  2D9X A;  2W2X D;  4TYZ A;  3ODW A;  1UPQ A;  2D11 A;  2Z4D A;  4HB4 B;  3PG7 A;  1SGH A;  2PXG A;  1V89 A;  2YS1 A;  2Z0P A;  1LB1 A;  3TW1 A;  2DFK A;  2KUP A;  2KIE A;  5D3Y A;  4KHA A;  4WJ7 A;  4K2P A;  1I2H A;  4YON A;  3F5R A;  4WSF A;  2RGN B;  2RVB B;  3FVC A;  4GN1 A;  2H7E A;  2NBV A;  2DKP A;  4Z2N A;  4QJ4 B;  4QJ3 B;  4EMO A;  5HE0 A;  2GS0 A;  2YVC A;  2I5F A;  2CAY A;  3A8Q A;  2DX5 A;  3DXC A;  3BJI A;  5D3W A;  2OTX A;  3VOQ A;  1BTK A;  1WJ1 A;  2CY5 A;  1MKE A;  3N7C A;  3HSA A;  5LOP B;  2DA0 A;  1V5P A;  1XCG A;  2OQB A;  2RLO A;  4P7I A;  3TO1 A;  2LYD A;  2VRW B;  2YSZ A;  3C4P B;  1V5U A;  1U5E A;  1GC7 A;  3NWA A;  2I1K A;  5KQ1 A;  1DDV A;  1LW3 A;  3P6A A;  2P0H A;  2X18 A;  2COC A;  3U8Z A;  1MI1 A;  2D9Y A;  2KCJ A;  1KI1 B;  3SYX A;  3PP2 A;  3GMU B;  2Z14 A;  3B77 A;  4PNK A;  2DYQ A;  2AEH A;  5C16 A;  1NTY A;  1AWE A;  3A8P A;  3NWF A;  3C4O B;  4OSN A;  2HTH B;  1JTG B;  1H4R A;  1B55 A;  4A5K A;  4D6W A;  2RNR B;  5JHH A;  2H7D A;  4IFS A;  1MPH A;  3KY9 A;  2DLW A;  4DM5 A;  2HE7 A;  1WVH A;  3E2L C;  1FGY A;  1TJ6 A;  2ROZ B;  4GOU A;  2N23 A;  3OAN A;  4KAX B;  5FI1 A;  4IOY X;  3V5W A;  4EJN A;  1UPR A;  5DHF B;  2DHI A;  3NW8 A;  3QIJ A;  3D4E A;  4GMX B;  1KZG A;  2Y7B A;  4K17 A;  3AU5 A;  2XQN M;  1NTV A;  3ML4 A;  5D3V A;  1DBH A;  1WGU A;  3M1I B;  1XR0 B;  2RRF A;  1J0W A;  1OQN A;  2I1J A;  3KRW A;  4HB0 B;  4KVG B;  4Z2M B;  1V5M A;  4HB2 B;  1K5G B;  2LG1 A;  4D0N B;  3C7V B;  2DKQ A;  3KZ1 A;  2YRY A;  4CHJ A;  2G2U B;  2COA A;  2ADZ A;  3PVW A;  3T06 A;  5KCV A;  2J59 M;  4MY6 A;  1K5D B;  4TKN A;  5J3T A;  1W1H A;  2Q13 A;  2JP2 A;  2YT2 A;  3SUZ A;  1RJ2 A;  4HAT B;  5C6R A;  2GJY A;  2QKL A;  3DXD A;  5CLL B;  3BIN A;  2Z0Q A;  2ROV A;  3KRX A;  2J0J A;  4Y94 A;  3ODX A;  3HIE A;  5L81 A;  4A6F A;  4HB3 B;  5J3Q A;  4KHB A;  2V76 A;  2LOX A;  4C0A A;  4QJ5 B;  4XWX A;  2L1C A;  2UZS A;  1MIX A;  1WGQ A;  2D9Z A;  3A98 B;  1MIZ B;  1ZSQ A;  2EJ8 A;  3MPX A;  2VKI A;  2AL6 A;  3GYO A;  4L6E A;  2YH9 A;  2EC1 A;  4HDQ A;  5EKQ E;  2VSZ A;  1N3H A;  1PFJ A;  2I5C A;  2GCL A;  3NSU A;  5M4Y B;  5D0O E;  2K8E A;  3QBV B;  4HSI A;  1WI1 A;  3ODO A;  1P3R A;  4CYE A;  4K81 A;  5D3X A;  4DX9 0;  2ELB A;  4ZRK A;  3P7Z A;  2P8V A;  2ZPY A;  5LG4 B;  5GOW B;  1I7A A;  5HE2 A;  2DHK A;  2BCJ A;  2GCJ A;  4HAV B;  3AU4 A;  5I2M A;  2YS5 A;  3SNH A;  5EFX A;  3DXE A;  2K2U A;  5C79 A;  1W1D A;  2COD A;  1FHW A;  3HK0 A;  2D4Q A;  4DBB A;  3ULB A;  1U27 A;  1MK9 B;  1XD4 A;  2RUK B;  4NY0 A;  1T77 A;  3AJ4 A;  4B6H A;  2EMT A;  1W1G A;  4ZRI A;  5DH9 B;  1DDM A;  3C7U B;  1X86 A;  2G35 A;  2N0Y A;  3FM8 C;  3TCA A;  3NWD A;  1XXM C;  1QC6 A;  2DHJ A;  1MK7 B;  3TFM A;  4OT1 A;  5JP4 A;  2J0K A;  1E5W A;  1H10 A;  4DXA B;  3E2K C;  3CIK A; 
#chains in the Genus database with same CATH homology
 2Z13 A;  2KXX A;  4L1R A;  2YT2 A;  3U12 A;  2KM7 A;  2GUM A;  3N4I B;  3TO1 A;  4QXA B;  3C4P B;  3NWA A;  3HIE A;  4KHB A;  4QJ5 B;  3A58 A;  5IRS A;  3GYO A;  3GMU B;  2YH9 A;  2Z14 A;  4KHO A;  5EKQ E;  1S0W C;  5M4Y B;  3NWF A;  2GCL A;  5D0O E;  3C4O B;  4OSN A;  5AYW E;  2FJU B;  2K8E A;  1JTG B;  4HSI A;  2ZKM X;  2KUQ A;  4D6W A;  3OHM B;  1ZYI A;  3FSS A;  4IFS A;  4DIX A;  5LG4 B;  2Z59 A;  5I2S A;  4CSQ A;  4DM5 A;  2GCJ A;  3GYP A;  3E2L C;  5I2M A;  2B5R C;  4GOU A;  5D0Q E;  4GNK B;  4IOY X;  2R2Y A;  2Z4D A;  3NW8 A;  3D4E A;  2PXG A;  3TW1 A;  2KIE A;  4KHB B;  4KHA A;  3C7U B;  2RRF A;  3FVC A;  2K49 A;  2NBV A;  4Z2M B;  4Z2N A;  4QJ4 B;  2G2W B;  4QJ3 B;  3NWD A;  1XXM C;  3C7V B;  3TVV A;  4OT1 A;  2KIG A;  2KR0 A;  3E2K C;  4PQ0 A;  2G2U B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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