4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Envelope glycoprotein B
publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
source organism Human herpesvirus 1
molecule tags Viral protein
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
3NW8A 4OT1A 4HSIA 3FVCA 3NWFA 3NWAA 4L1RA 3NWDA 4OSNA 2GUMA
chains in the Genus database with same CATH superfamily
3P7ZA 1V5MA 2KCJA 4KAXB 3NWAA 1FHXA 3PVLA 2DX5A 3PZDA 1V88A 1LB1A 4MY6A 4QJ4B 2X18A 2D2QA 4HB2B 4BBKA 3SUZA 4IFSA 2K2JA 1U27A 1NI2A 2COFA 1UNRA 3D8DA 5D3YA 4DBBA 4IAPA 1GC6A 3KRXA 4DM5A 4C0AA 4QXAB 2I1JA 2M14A 3AU4A 1FHWA 2LYDA 2Q13A 1DDWA 4F7HA 5I2MA 3PVWA 2DHJA 2B5RC 2DX1A 1TJ6A 4D0NB 1SGHA 3D8FA 2G2WB 1KZ7A 3ODWA 1I2HA 4KHBB 2EC1A 3FEHA 5D27A 1H10A 1FAOA 4P7IA 4A5KA 1ZYIA 3A58A 2UVMA 3A8PA 5C16A 1FOEA 2LULA 2FJUB 1XXMC 2I5CA 2L1CA 3B77A 3ML4A 2UZSA 3WA0A 1B55A 2YS1A 3NSUA 1AQCA 3A98B 5LG4B 2KUQA 3HIEA 3PSCA 2UZRA 1BTKA 1V5UA 2Y8FA 1OY2A 1TXDA 1X1FA 2RUKB 4HAXB 4HDQA 3D8EA 2MDXA 2YSZA 2QKMA 1PFJA 2DHKA 2NZ8B 1AWEA 3VOQA 2D9VA 2W2WA 4QJ3B 2R0DA 2H7EA 1XKEA 2YT0A 3U8ZA 1U5DA 1X1GA 4OT1A 5J3QA 4CSQA 4KHOA 1BWNA 2DKPA 4PQ0A 1XR0B 1WJMA 2KIEA 3E2LC 4TKNA 2JP2A 2ELAA 2YS5A 4HB0B 2AL6A 3FSSA 2K8EA 2DFKA 1TQZA 2VSZA 5FI1A 1J0WA 4A6FA 3G9WA 3MPXA 1U5EA 2YF0A 3NW8A 1DDMA 5J3TA 1WI1A 2J59M 3TO1A 3GMUB 3AJ4A 4DX8A 3TW1A 1JTGB 1MPHA 3GYPA 2Z4DA 2QKLA 1P3RA 2RRFA 3C7UB 2CODA 1SHCA 2COAA 5KCVA 4Z2MB 2HE7A 1MAIA 3DXEA 1Y19B 3C4PB 2IFSA 2GCLA 2KGXB 2LOZA 3FVCA 1M7EA 2KIGA 2DLWA 2W2XC 2BCJA 5C79A 2EMTA 1T77A 1K5GB 3V5WA 2K00A 3QBVB 3RCPA 4NY0A 3N7CA 1DYNA 1LW3A 4GN1A 2YT2A 3F5RA 2GJYA 3QWMA 2W2XD 2DA0A 4PNKA 3ODXA 3U7DA 2GUMA 4MT7A 4A6HA 2YH9A 2EMSA 5JHGA 3ZDTA 2Z14A 1M7RA 1FGYA 5KQ1A 1ZM0A 2RGNB 5DI9B 2RLOA 2RNRB 1EAZA 1FHOA 3CIKA 3T06A 5JHHA 4HB4B 2MFQA 3TCAA 1X11A 2R2YA 1W1DA 1XCGA 4KHAA 4TYZA 3HK0A 2DYNA 4A6KA 5HE0A 1NU2A 4HSIA 2ZKMX 4Y94A 5HE1A 5KQ4A 1WJ1A 1MKEA 2Y8GA 4HAZB 3PVUA 3FM8C 2N0YA 3NWDA 1V89A 5M4YB 4QJ5B 4KHBA 2LG1A 5DIFB 3PP2A 1MI1A 5L81A 5JLJB 1ZC3B 2P0HA 1GC7A 1V61A 2K2UA 2GS0A 2D9WA 2PXGA 3A8QA 2LKOA 3U12A 5CLQB 3DXCA 2K49A 2G2UB 2OQBA 2I1KA 2J0KA 5IRSA 4EJNA 4HATB 3IVFA 2D10A 4H8SA 5D3VA 1KZGA 3O96A 1GG3A 4DIXA 4L6EA 2ROVA 3SYXA 2CY4A 2XQNM 4IOYX 3C7VB 5AYWE 4HHVA 4EMOA 1FGZA 3DCXA 1XX0A 5DH9B 2COCA 2P8VA 3F0WA 1X86A 5CLLB 2D9YA 2J0JA 2LOXA 2DYQA 5DHFB 1Q67A 2MWNB 2NMBA 4WSFA 3NWFA 4EKUA 1P5TA 4F7UP 1PMSA 1FB8A 4YONA 1MIZB 1UNQA 1S0WC 3SO6A 1NTYA 5C5BB 1ISNA 1UNPA 4XWXA 3GYOA 2KUPA 2YVCA 1OMWA 5D3WA 1J19A 1U2BA 2Z0QA 2YRYA 2R09A 4GMXB 4K17A 1W1GA 3CXBB 2RVBB 4HAYB 1K5DB 2DN6A 2CRFA 4WVFB 1BTNA 3AU5A 4ZRKA 2N23A 5D3XA 1V5PA 4GXBA 5GOWB 1W1HA 2P0DA 2RSGA 2L2IA 2DHIA 5J3YA 2D4QA 4OSNA 2D11A 2VKIA 3TVVA 4L1RA 1ZC4B 3E2KC 1OQNA 3TFMA 3SV1A 2GCJA 1U5FA 4D6WA 2KM7A 2MKRA 3ZVRA 4GOUA 3BINA 4HAVB 3BJIA 1P6SA 4Z2NA 2IYBA 4DX90 2ROZB 4ZRJA 2P0FA 3OHMB 2E2XA 2VRWB 3D4EA 2M38A 1EGXA 2DTCA 3VIAA 1H4RA 2I5FA 2FJLA 1UEFA 1XD4A 1U5GA 3QIJA 4GMVA 4K2PA 2DKQA 4GNKB 1XODA 1ZSQA 1PLSA 1Y5OA 5DHAB 3WYFB 1U29A 5LOPB 5EKQE 4HDOA 3N4IB 2KR0A 5HE3A 3P6AA 2NBVA 3HQCA 1DBHA 1RRPB 1BAKA 2J0MA 2AEHA 1MIXA 2ADZA 2Z0OA 3ULCA 2D9ZA 5FI0A 4MK0A 5EFXA 5I2SA 1KI1B 1MK9B 4KVGB 1QQGA 2Y7BA 1QC6A 4HAWB 4ZRIA 1DDVA 4A6FB 3ODOA 1X05A 1WG7A 1I7AA 3PG7A 2EJ8A 2HTHB 4DXAB 1WGUA 1ZVRA 2ELBA 3LJUX 4K81A 1EVHA 1UPRA 4YL8A 3SNHA 3UZTA 1RJ2A 1WGQA 2Z59A 4CHJA 1IRSA 1UPQA 4WJ7A 1NTVA 2KXXA 2CAYA 5JP4A 2G35A 1E5WA 3MDBC 2YS3A 5HE2A 3C4OB 3OANA 3X23A 2H7DA 5D0QE 3HSAA 2YT1A 3KRWA 2D9XA 1N3HA 4CHMA 4F7GA 1EF1A 3KY9A 4NSWA 1MK7B 4GPTB 4GZUA 2PZ1A 4K2OA 5D0OE 2CY5A 3PEGA 2ZPYA 4HAUB 1DROA 3DXDA 3KSYA 2Z0PA 4B6HA 3M1IB 1WVHA 5C5BA 5LONB 5C6RA 3HW2B 1Z87A 3ULBA 4HB3B 2Z13A 3KZ1A 4CYEA 2V76A 2OTXA
chains in the Genus database with same CATH topology
4Z2NA 3U12A 3NWAA 2K49A 2G2UB 3OHMB 3TW1A 1JTGB 3GYPA 3D4EA 5IRSA 4QJ4B 2Z4DA 2RRFA 3C7UB 4IFSA 4Z2MB 4DIXA 4GNKB 3C4PB 4DM5A 4QXAB 4IOYX 3C7VB 5AYWE 5EKQE 3N4IB 2GCLA 2KR0A 2NBVA 3FVCA 5I2MA 2B5RC 2KIGA 2G2WB 3NWFA 4KHBB 5I2SA 1S0WC 1ZYIA 3A58A 2YT2A 3GYOA 2FJUB 1XXMC 2GUMA 2YH9A 2Z14A 5LG4B 2KUQA 2Z59A 3HIEA 2KXXA 2R2YA 4KHAA 3C4OB 5D0QE 4HSIA 2ZKMX 4QJ3B 4OT1A 4CSQA 4KHOA 4PQ0A 3NWDA 4OSNA 5M4YB 5D0OE 2KIEA 4QJ5B 4KHBA 3E2LC 3TVVA 4L1RA 3FSSA 2K8EA 3E2KC 2GCJA 2KM7A 4D6WA 3NW8A 2Z13A 4GOUA 2PXGA 3GMUB 3TO1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NW8 A;  4OT1 A;  4HSI A;  3FVC A;  3NWF A;  3NWA A;  4L1R A;  3NWD A;  4OSN A;  2GUM A; 
#chains in the Genus database with same CATH topology
 3P7Z A;  1V5M A;  2KCJ A;  4KAX B;  3NWA A;  1FHX A;  3PVL A;  2DX5 A;  3PZD A;  1V88 A;  1LB1 A;  4MY6 A;  4QJ4 B;  2X18 A;  2D2Q A;  4HB2 B;  4BBK A;  3SUZ A;  4IFS A;  2K2J A;  1U27 A;  1NI2 A;  2COF A;  1UNR A;  3D8D A;  5D3Y A;  4DBB A;  4IAP A;  1GC6 A;  3KRX A;  4DM5 A;  4C0A A;  4QXA B;  2I1J A;  2M14 A;  3AU4 A;  1FHW A;  2LYD A;  2Q13 A;  1DDW A;  4F7H A;  5I2M A;  3PVW A;  2DHJ A;  2B5R C;  2DX1 A;  1TJ6 A;  4D0N B;  1SGH A;  3D8F A;  2G2W B;  1KZ7 A;  3ODW A;  1I2H A;  4KHB B;  2EC1 A;  3FEH A;  5D27 A;  1H10 A;  1FAO A;  4P7I A;  4A5K A;  1ZYI A;  3A58 A;  2UVM A;  3A8P A;  5C16 A;  1FOE A;  2LUL A;  2FJU B;  1XXM C;  2I5C A;  2L1C A;  3B77 A;  3ML4 A;  2UZS A;  3WA0 A;  1B55 A;  2YS1 A;  3NSU A;  1AQC A;  3A98 B;  5LG4 B;  2KUQ A;  3HIE A;  3PSC A;  2UZR A;  1BTK A;  1V5U A;  2Y8F A;  1OY2 A;  1TXD A;  1X1F A;  2RUK B;  4HAX B;  4HDQ A;  3D8E A;  2MDX A;  2YSZ A;  2QKM A;  1PFJ A;  2DHK A;  2NZ8 B;  1AWE A;  3VOQ A;  2D9V A;  2W2W A;  4QJ3 B;  2R0D A;  2H7E A;  1XKE A;  2YT0 A;  3U8Z A;  1U5D A;  1X1G A;  4OT1 A;  5J3Q A;  4CSQ A;  4KHO A;  1BWN A;  2DKP A;  4PQ0 A;  1XR0 B;  1WJM A;  2KIE A;  3E2L C;  4TKN A;  2JP2 A;  2ELA A;  2YS5 A;  4HB0 B;  2AL6 A;  3FSS A;  2K8E A;  2DFK A;  1TQZ A;  2VSZ A;  5FI1 A;  1J0W A;  4A6F A;  3G9W A;  3MPX A;  1U5E A;  2YF0 A;  3NW8 A;  1DDM A;  5J3T A;  1WI1 A;  2J59 M;  3TO1 A;  3GMU B;  3AJ4 A;  4DX8 A;  3TW1 A;  1JTG B;  1MPH A;  3GYP A;  2Z4D A;  2QKL A;  1P3R A;  2RRF A;  3C7U B;  2COD A;  1SHC A;  2COA A;  5KCV A;  4Z2M B;  2HE7 A;  1MAI A;  3DXE A;  1Y19 B;  3C4P B;  2IFS A;  2GCL A;  2KGX B;  2LOZ A;  3FVC A;  1M7E A;  2KIG A;  2DLW A;  2W2X C;  2BCJ A;  5C79 A;  2EMT A;  1T77 A;  1K5G B;  3V5W A;  2K00 A;  3QBV B;  3RCP A;  4NY0 A;  3N7C A;  1DYN A;  1LW3 A;  4GN1 A;  2YT2 A;  3F5R A;  2GJY A;  3QWM A;  2W2X D;  2DA0 A;  4PNK A;  3ODX A;  3U7D A;  2GUM A;  4MT7 A;  4A6H A;  2YH9 A;  2EMS A;  5JHG A;  3ZDT A;  2Z14 A;  1M7R A;  1FGY A;  5KQ1 A;  1ZM0 A;  2RGN B;  5DI9 B;  2RLO A;  2RNR B;  1EAZ A;  1FHO A;  3CIK A;  3T06 A;  5JHH A;  4HB4 B;  2MFQ A;  3TCA A;  1X11 A;  2R2Y A;  1W1D A;  1XCG A;  4KHA A;  4TYZ A;  3HK0 A;  2DYN A;  4A6K A;  5HE0 A;  1NU2 A;  4HSI A;  2ZKM X;  4Y94 A;  5HE1 A;  5KQ4 A;  1WJ1 A;  1MKE A;  2Y8G A;  4HAZ B;  3PVU A;  3FM8 C;  2N0Y A;  3NWD A;  1V89 A;  5M4Y B;  4QJ5 B;  4KHB A;  2LG1 A;  5DIF B;  3PP2 A;  1MI1 A;  5L81 A;  5JLJ B;  1ZC3 B;  2P0H A;  1GC7 A;  1V61 A;  2K2U A;  2GS0 A;  2D9W A;  2PXG A;  3A8Q A;  2LKO A;  3U12 A;  5CLQ B;  3DXC A;  2K49 A;  2G2U B;  2OQB A;  2I1K A;  2J0K A;  5IRS A;  4EJN A;  4HAT B;  3IVF A;  2D10 A;  4H8S A;  5D3V A;  1KZG A;  3O96 A;  1GG3 A;  4DIX A;  4L6E A;  2ROV A;  3SYX A;  2CY4 A;  2XQN M;  4IOY X;  3C7V B;  5AYW E;  4HHV A;  4EMO A;  1FGZ A;  3DCX A;  1XX0 A;  5DH9 B;  2COC A;  2P8V A;  3F0W A;  1X86 A;  5CLL B;  2D9Y A;  2J0J A;  2LOX A;  2DYQ A;  5DHF B;  1Q67 A;  2MWN B;  2NMB A;  4WSF A;  3NWF A;  4EKU A;  1P5T A;  4F7U P;  1PMS A;  1FB8 A;  4YON A;  1MIZ B;  1UNQ A;  1S0W C;  3SO6 A;  1NTY A;  5C5B B;  1ISN A;  1UNP A;  4XWX A;  3GYO A;  2KUP A;  2YVC A;  1OMW A;  5D3W A;  1J19 A;  1U2B A;  2Z0Q A;  2YRY A;  2R09 A;  4GMX B;  4K17 A;  1W1G A;  3CXB B;  2RVB B;  4HAY B;  1K5D B;  2DN6 A;  2CRF A;  4WVF B;  1BTN A;  3AU5 A;  4ZRK A;  2N23 A;  5D3X A;  1V5P A;  4GXB A;  5GOW B;  1W1H A;  2P0D A;  2RSG A;  2L2I A;  2DHI A;  5J3Y A;  2D4Q A;  4OSN A;  2D11 A;  2VKI A;  3TVV A;  4L1R A;  1ZC4 B;  3E2K C;  1OQN A;  3TFM A;  3SV1 A;  2GCJ A;  1U5F A;  4D6W A;  2KM7 A;  2MKR A;  3ZVR A;  4GOU A;  3BIN A;  4HAV B;  3BJI A;  1P6S A;  4Z2N A;  2IYB A;  4DX9 0;  2ROZ B;  4ZRJ A;  2P0F A;  3OHM B;  2E2X A;  2VRW B;  3D4E A;  2M38 A;  1EGX A;  2DTC A;  3VIA A;  1H4R A;  2I5F A;  2FJL A;  1UEF A;  1XD4 A;  1U5G A;  3QIJ A;  4GMV A;  4K2P A;  2DKQ A;  4GNK B;  1XOD A;  1ZSQ A;  1PLS A;  1Y5O A;  5DHA B;  3WYF B;  1U29 A;  5LOP B;  5EKQ E;  4HDO A;  3N4I B;  2KR0 A;  5HE3 A;  3P6A A;  2NBV A;  3HQC A;  1DBH A;  1RRP B;  1BAK A;  2J0M A;  2AEH A;  1MIX A;  2ADZ A;  2Z0O A;  3ULC A;  2D9Z A;  5FI0 A;  4MK0 A;  5EFX A;  5I2S A;  1KI1 B;  1MK9 B;  4KVG B;  1QQG A;  2Y7B A;  1QC6 A;  4HAW B;  4ZRI A;  1DDV A;  4A6F B;  3ODO A;  1X05 A;  1WG7 A;  1I7A A;  3PG7 A;  2EJ8 A;  2HTH B;  4DXA B;  1WGU A;  1ZVR A;  2ELB A;  3LJU X;  4K81 A;  1EVH A;  1UPR A;  4YL8 A;  3SNH A;  3UZT A;  1RJ2 A;  1WGQ A;  2Z59 A;  4CHJ A;  1IRS A;  1UPQ A;  4WJ7 A;  1NTV A;  2KXX A;  2CAY A;  5JP4 A;  2G35 A;  1E5W A;  3MDB C;  2YS3 A;  5HE2 A;  3C4O B;  3OAN A;  3X23 A;  2H7D A;  5D0Q E;  3HSA A;  2YT1 A;  3KRW A;  2D9X A;  1N3H A;  4CHM A;  4F7G A;  1EF1 A;  3KY9 A;  4NSW A;  1MK7 B;  4GPT B;  4GZU A;  2PZ1 A;  4K2O A;  5D0O E;  2CY5 A;  3PEG A;  2ZPY A;  4HAU B;  1DRO A;  3DXD A;  3KSY A;  2Z0P A;  4B6H A;  3M1I B;  1WVH A;  5C5B A;  5LON B;  5C6R A;  3HW2 B;  1Z87 A;  3ULB A;  4HB3 B;  2Z13 A;  3KZ1 A;  4CYE A;  2V76 A;  2OTX A; 
#chains in the Genus database with same CATH homology
 4Z2N A;  3U12 A;  3NWA A;  2K49 A;  2G2U B;  3OHM B;  3TW1 A;  1JTG B;  3GYP A;  3D4E A;  5IRS A;  4QJ4 B;  2Z4D A;  2RRF A;  3C7U B;  4IFS A;  4Z2M B;  4DIX A;  4GNK B;  3C4P B;  4DM5 A;  4QXA B;  4IOY X;  3C7V B;  5AYW E;  5EKQ E;  3N4I B;  2GCL A;  2KR0 A;  2NBV A;  3FVC A;  5I2M A;  2B5R C;  2KIG A;  2G2W B;  3NWF A;  4KHB B;  5I2S A;  1S0W C;  1ZYI A;  3A58 A;  2YT2 A;  3GYO A;  2FJU B;  1XXM C;  2GUM A;  2YH9 A;  2Z14 A;  5LG4 B;  2KUQ A;  2Z59 A;  3HIE A;  2KXX A;  2R2Y A;  4KHA A;  3C4O B;  5D0Q E;  4HSI A;  2ZKM X;  4QJ3 B;  4OT1 A;  4CSQ A;  4KHO A;  4PQ0 A;  3NWD A;  4OSN A;  5M4Y B;  5D0O E;  2KIE A;  4QJ5 B;  4KHB A;  3E2L C;  3TVV A;  4L1R A;  3FSS A;  2K8E A;  3E2K C;  2GCJ A;  2KM7 A;  4D6W A;  3NW8 A;  2Z13 A;  4GOU A;  2PXG A;  3GMU B;  3TO1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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