4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
source organism Human herpesvirus 1
molecule tags Viral protein
molecule keywords Envelope glycoprotein B
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
3NWDA 2GUMA 4HSIA 3FVCA 3NWAA 3NWFA 3NW8A 4OSNA 4L1RA 4OT1A
chains in the Genus database with same CATH superfamily
3VIAA 2P0HA 3B77A 4DX8A 5D3YA 3OHMB 3A8QA 3RCPA 2D2QA 5EFXA 1K5DB 2E2XA 1ZM0A 1MKEA 1FAOA 4CYEA 4A6HA 2UZRA 3NWAA 1FHXA 5DH9B 2FJUB 4HSIA 4DXAB 4CSQA 1FGYA 1NTVA 1WJMA 1DROA 2LOZA 1Y19B 2D9WA 2I1KA 3M1IB 5AYWE 2XQNM 4PNKA 1XCGA 4DBBA 3D8EA 1I7AA 2LYDA 2K2UA 2YT0A 4ZRIA 2ROZB 4A6FA 4CHMA 3SYXA 2DX5A 2G35A 2Z0QA 2Y7BA 4DIXA 1DYNA 2EJ8A 3O96A 5JHGA 1MAIA 2MKRA 2DKPA 2RVBB 4C0AA 2CODA 2YVCA 2D9ZA 1BWNA 1WGUA 3N4IB 3P7ZA 2NZ8B 2YS3A 3HIEA 1U5EA 3F5RA 2YS5A 3LJUX 4DX90 4WSFA 1AWEA 2EMTA 3NWDA 2V76A 2EC1A 4GMXB 2ELBA 3PG7A 1LB1A 4EKUA 3D8DA 1UPQA 3HW2B 1UPRA 5HE3A 3CXBB 1UNRA 5D0QE 5J3YA 2DKQA 1TXDA 1J0WA 1NU2A 1ZVRA 4QJ5B 5C5BA 5KQ4A 2BCJA 2M38A 2I1JA 2KGXB 2RRFA 2Q13A 2LULA 1S0WC 5D3XA 2GUMA 5JLJB 1MPHA 1RJ2A 2D11A 1XXMC 4Y94A 4QJ3B 2D4QA 2D9XA 2YH9A 2X18A 4KHAA 2RLOA 2ADZA 1X05A 4D0NB 1DBHA 2K8EA 5D3VA 2PZ1A 3A58A 2J0KA 2MFQA 3HK0A 1GC6A 3OANA 3KSYA 5JP4A 4WJ7A 1FOEA 2H7EA 3ODXA 4A5KA 1GC7A 1MK9B 5IRSA 4EJNA 5HE0A 3TO1A 1X1GA 2KUQA 3GYPA 3ODWA 4HHVA 2G2WB 4XWXA 2DYNA 1WVHA 3C7VB 2W2WA 3D8FA 4HAVB 2NMBA 1DDWA 2MWNB 2DFKA 3DCXA 4HB4B 1E5WA 1X1FA 4Z2MB 4MT7A 3QIJA 5D3WA 1FGZA 1IRSA 2CY5A 4HAXB 3PVUA 4KHBB 5HE2A 4YL8A 5DIFB 3X23A 1DDVA 2R2YA 2KXXA 5I2SA 3IVFA 4H8SA 5J3TA 2UVMA 3BJIA 4HB0B 2KM7A 4MK0A 2YT2A 4KAXB 3VOQA 4CHJA 3SV1A 2KIGA 2Z14A 5FI0A 3PVLA 3AJ4A 3ULCA 4IOYX 3WYFB 5CLQB 5LG4B 2KR0A 4NSWA 4TYZA 1Y5OA 4OSNA 5KQ1A 1QC6A 1V61A 1OQNA 4K2OA 4HAWB 3U7DA 2J59M 1QQGA 1MK7B 2D10A 2W2XC 4YONA 2QKMA 1OY2A 2GJYA 1V5MA 1V5UA 2LOXA 2Y8FA 2Z0OA 5DHAB 4ZRKA 1V89A 5D0OE 2L1CA 3BINA 2R0DA 1GG3A 2IFSA 2PXGA 3FM8C 1WI1A 1H10A 1MIZB 1WJ1A 4GNKB 3C4OB 3KY9A 1U5DA 2YS1A 1SGHA 2DN6A 2VKIA 4IAPA 1WG7A 3P6AA 4F7HA 2KUPA 1Z87A 2KCJA 4KHOA 2K49A 5EKQE 1TQZA 3AU4A 5FI1A 3KRWA 3HSAA 1FHWA 3UZTA 2DLWA 2GS0A 1ZSQA 2CY4A 1P3RA 5L81A 4GOUA 2DA0A 2MDXA 2YT1A 3DXCA 1XR0B 4HATB 3PP2A 3MPXA 3ML4A 3V5WA 1XODA 1XD4A 1K5GB 2G2UB 3TW1A 2H7DA 4P7IA 4HAUB 3NWFA 4K81A 2DYQA 2N0YA 1U5GA 1MIXA 1NTYA 1XX0A 1ZC4B 5DI9B 3FEHA 1KI1B 1LW3A 1AQCA 1M7RA 4F7GA 1X11A 3A8PA 2Z59A 4HAZB 5LONB 4K2PA 2DHKA 2GCLA 3TVVA 1DDMA 3WA0A 3KRXA 1ZYIA 5LOPB 1UNQA 3U8ZA 4GZUA 4DM5A 1XKEA 2CRFA 1RRPB 2OTXA 2IYBA 3G9WA 1MI1A 1P6SA 2COCA 3TFMA 4F7UP 2RGNB 2RUKB 1ZC3B 2I5FA 3DXEA 4GPTB 2AL6A 4A6FB 3ODOA 3FVCA 4PQ0A 3NW8A 2GCJA 1UEFA 4KVGB 3TCAA 3E2KC 2RSGA 2HTHB 3C4PB 2J0JA 2UZSA 4BBKA 4IFSA 3HQCA 3A98B 2LKOA 2OQBA 4QXAB 2NBVA 2ELAA 1V88A 2I5CA 5KCVA 1U2BA 2KIEA 3PEGA 3SNHA 3MDBC 1EAZA 4NY0A 1EVHA 3CIKA 1J19A 2VSZA 2Z0PA 3QWMA 2W2XD 3D4EA 2QKLA 4ZRJA 3ZVRA 2Z4DA 2N23A 4HDOA 5C5BB 3ZDTA 3FSSA 4B6HA 1EF1A 4L6EA 5GOWB 2J0MA 2Y8GA 1H4RA 1PLSA 3N7CA 4L1RA 5I2MA 1U29A 3E2LC 1N3HA 1KZGA 4A6KA 4KHBA 5HE1A 2FJLA 5C16A 3T06A 4HDQA 1Q67A 3U12A 4HB3B 2HE7A 4HB2B 2EMSA 4QJ4B 2DX1A 1WGQA 2RNRB 1OMWA 2YSZA 2VRWB 1SHCA 4EMOA 2D9YA 1M7EA 3PSCA 5C79A 2L2IA 4GMVA 2ROVA 3ULBA 1KZ7A 2M14A 1U27A 5C6RA 1I2HA 4HAYB 2P8VA 4OT1A 3F0WA 2JP2A 1BTKA 1UNPA 4K17A 2DTCA 3KZ1A 5D27A 5DHFB 1FB8A 3AU5A 3GMUB 5JHHA 1V5PA 3C7UB 1W1DA 1W1GA 4D6WA 1EGXA 2DHIA 3SO6A 1PMSA 2P0FA 4MY6A 1BAKA 4WVFB 2D9VA 2LG1A 3NSUA 1BTNA 2K2JA 3DXDA 2COFA 1JTGB 2DHJA 1PFJA 3GYOA 5J3QA 1TJ6A 1NI2A 4Z2NA 3SUZA 1B55A 1X86A 2CAYA 2Z13A 4GN1A 5CLLB 1FHOA 4TKNA 2K00A 2COAA 2ZPYA 1P5TA 2YF0A 3QBVB 2AEHA 1ISNA 2ZKMX 3PVWA 4GXBA 2B5RC 3PZDA 2P0DA 1U5FA 5M4YB 1T77A 1W1HA 2YRYA 2R09A
chains in the Genus database with same CATH topology
2K8EA 2Z4DA 3A58A 4KHOA 3FSSA 2K49A 5EKQE 3OHMB 4L1RA 5I2MA 3E2LC 5IRSA 4KHBA 4GOUA 3TO1A 3U12A 2KUQA 3GYPA 3NWAA 2G2WB 2G2UB 2FJUB 3C7VB 3TW1A 4QJ4B 4HSIA 4CSQA 3NWFA 4Z2MB 5AYWE 2Z59A 2GCLA 3TVVA 4KHBB 4OT1A 2R2YA 2KXXA 5I2SA 1ZYIA 3GMUB 4DIXA 3C7UB 2KM7A 4D6WA 4DM5A 3N4IB 2YT2A 2KIGA 2Z14A 3HIEA 4IOYX 3NWDA 5LG4B 2KR0A 4OSNA 1JTGB 3FVCA 4PQ0A 3NW8A 2GCJA 3GYOA 5D0QE 4QJ5B 4Z2NA 3E2KC 3C4PB 2RRFA 1S0WC 2GUMA 2Z13A 4IFSA 5D0OE 1XXMC 4QXAB 2NBVA 4QJ3B 2ZKMX 2PXGA 2KIEA 2B5RC 3C4OB 4GNKB 2YH9A 5M4YB 4KHAA 3D4EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NWD A;  2GUM A;  4HSI A;  3FVC A;  3NWA A;  3NWF A;  3NW8 A;  4OSN A;  4L1R A;  4OT1 A; 
#chains in the Genus database with same CATH topology
 3VIA A;  2P0H A;  3B77 A;  4DX8 A;  5D3Y A;  3OHM B;  3A8Q A;  3RCP A;  2D2Q A;  5EFX A;  1K5D B;  2E2X A;  1ZM0 A;  1MKE A;  1FAO A;  4CYE A;  4A6H A;  2UZR A;  3NWA A;  1FHX A;  5DH9 B;  2FJU B;  4HSI A;  4DXA B;  4CSQ A;  1FGY A;  1NTV A;  1WJM A;  1DRO A;  2LOZ A;  1Y19 B;  2D9W A;  2I1K A;  3M1I B;  5AYW E;  2XQN M;  4PNK A;  1XCG A;  4DBB A;  3D8E A;  1I7A A;  2LYD A;  2K2U A;  2YT0 A;  4ZRI A;  2ROZ B;  4A6F A;  4CHM A;  3SYX A;  2DX5 A;  2G35 A;  2Z0Q A;  2Y7B A;  4DIX A;  1DYN A;  2EJ8 A;  3O96 A;  5JHG A;  1MAI A;  2MKR A;  2DKP A;  2RVB B;  4C0A A;  2COD A;  2YVC A;  2D9Z A;  1BWN A;  1WGU A;  3N4I B;  3P7Z A;  2NZ8 B;  2YS3 A;  3HIE A;  1U5E A;  3F5R A;  2YS5 A;  3LJU X;  4DX9 0;  4WSF A;  1AWE A;  2EMT A;  3NWD A;  2V76 A;  2EC1 A;  4GMX B;  2ELB A;  3PG7 A;  1LB1 A;  4EKU A;  3D8D A;  1UPQ A;  3HW2 B;  1UPR A;  5HE3 A;  3CXB B;  1UNR A;  5D0Q E;  5J3Y A;  2DKQ A;  1TXD A;  1J0W A;  1NU2 A;  1ZVR A;  4QJ5 B;  5C5B A;  5KQ4 A;  2BCJ A;  2M38 A;  2I1J A;  2KGX B;  2RRF A;  2Q13 A;  2LUL A;  1S0W C;  5D3X A;  2GUM A;  5JLJ B;  1MPH A;  1RJ2 A;  2D11 A;  1XXM C;  4Y94 A;  4QJ3 B;  2D4Q A;  2D9X A;  2YH9 A;  2X18 A;  4KHA A;  2RLO A;  2ADZ A;  1X05 A;  4D0N B;  1DBH A;  2K8E A;  5D3V A;  2PZ1 A;  3A58 A;  2J0K A;  2MFQ A;  3HK0 A;  1GC6 A;  3OAN A;  3KSY A;  5JP4 A;  4WJ7 A;  1FOE A;  2H7E A;  3ODX A;  4A5K A;  1GC7 A;  1MK9 B;  5IRS A;  4EJN A;  5HE0 A;  3TO1 A;  1X1G A;  2KUQ A;  3GYP A;  3ODW A;  4HHV A;  2G2W B;  4XWX A;  2DYN A;  1WVH A;  3C7V B;  2W2W A;  3D8F A;  4HAV B;  2NMB A;  1DDW A;  2MWN B;  2DFK A;  3DCX A;  4HB4 B;  1E5W A;  1X1F A;  4Z2M B;  4MT7 A;  3QIJ A;  5D3W A;  1FGZ A;  1IRS A;  2CY5 A;  4HAX B;  3PVU A;  4KHB B;  5HE2 A;  4YL8 A;  5DIF B;  3X23 A;  1DDV A;  2R2Y A;  2KXX A;  5I2S A;  3IVF A;  4H8S A;  5J3T A;  2UVM A;  3BJI A;  4HB0 B;  2KM7 A;  4MK0 A;  2YT2 A;  4KAX B;  3VOQ A;  4CHJ A;  3SV1 A;  2KIG A;  2Z14 A;  5FI0 A;  3PVL A;  3AJ4 A;  3ULC A;  4IOY X;  3WYF B;  5CLQ B;  5LG4 B;  2KR0 A;  4NSW A;  4TYZ A;  1Y5O A;  4OSN A;  5KQ1 A;  1QC6 A;  1V61 A;  1OQN A;  4K2O A;  4HAW B;  3U7D A;  2J59 M;  1QQG A;  1MK7 B;  2D10 A;  2W2X C;  4YON A;  2QKM A;  1OY2 A;  2GJY A;  1V5M A;  1V5U A;  2LOX A;  2Y8F A;  2Z0O A;  5DHA B;  4ZRK A;  1V89 A;  5D0O E;  2L1C A;  3BIN A;  2R0D A;  1GG3 A;  2IFS A;  2PXG A;  3FM8 C;  1WI1 A;  1H10 A;  1MIZ B;  1WJ1 A;  4GNK B;  3C4O B;  3KY9 A;  1U5D A;  2YS1 A;  1SGH A;  2DN6 A;  2VKI A;  4IAP A;  1WG7 A;  3P6A A;  4F7H A;  2KUP A;  1Z87 A;  2KCJ A;  4KHO A;  2K49 A;  5EKQ E;  1TQZ A;  3AU4 A;  5FI1 A;  3KRW A;  3HSA A;  1FHW A;  3UZT A;  2DLW A;  2GS0 A;  1ZSQ A;  2CY4 A;  1P3R A;  5L81 A;  4GOU A;  2DA0 A;  2MDX A;  2YT1 A;  3DXC A;  1XR0 B;  4HAT B;  3PP2 A;  3MPX A;  3ML4 A;  3V5W A;  1XOD A;  1XD4 A;  1K5G B;  2G2U B;  3TW1 A;  2H7D A;  4P7I A;  4HAU B;  3NWF A;  4K81 A;  2DYQ A;  2N0Y A;  1U5G A;  1MIX A;  1NTY A;  1XX0 A;  1ZC4 B;  5DI9 B;  3FEH A;  1KI1 B;  1LW3 A;  1AQC A;  1M7R A;  4F7G A;  1X11 A;  3A8P A;  2Z59 A;  4HAZ B;  5LON B;  4K2P A;  2DHK A;  2GCL A;  3TVV A;  1DDM A;  3WA0 A;  3KRX A;  1ZYI A;  5LOP B;  1UNQ A;  3U8Z A;  4GZU A;  4DM5 A;  1XKE A;  2CRF A;  1RRP B;  2OTX A;  2IYB A;  3G9W A;  1MI1 A;  1P6S A;  2COC A;  3TFM A;  4F7U P;  2RGN B;  2RUK B;  1ZC3 B;  2I5F A;  3DXE A;  4GPT B;  2AL6 A;  4A6F B;  3ODO A;  3FVC A;  4PQ0 A;  3NW8 A;  2GCJ A;  1UEF A;  4KVG B;  3TCA A;  3E2K C;  2RSG A;  2HTH B;  3C4P B;  2J0J A;  2UZS A;  4BBK A;  4IFS A;  3HQC A;  3A98 B;  2LKO A;  2OQB A;  4QXA B;  2NBV A;  2ELA A;  1V88 A;  2I5C A;  5KCV A;  1U2B A;  2KIE A;  3PEG A;  3SNH A;  3MDB C;  1EAZ A;  4NY0 A;  1EVH A;  3CIK A;  1J19 A;  2VSZ A;  2Z0P A;  3QWM A;  2W2X D;  3D4E A;  2QKL A;  4ZRJ A;  3ZVR A;  2Z4D A;  2N23 A;  4HDO A;  5C5B B;  3ZDT A;  3FSS A;  4B6H A;  1EF1 A;  4L6E A;  5GOW B;  2J0M A;  2Y8G A;  1H4R A;  1PLS A;  3N7C A;  4L1R A;  5I2M A;  1U29 A;  3E2L C;  1N3H A;  1KZG A;  4A6K A;  4KHB A;  5HE1 A;  2FJL A;  5C16 A;  3T06 A;  4HDQ A;  1Q67 A;  3U12 A;  4HB3 B;  2HE7 A;  4HB2 B;  2EMS A;  4QJ4 B;  2DX1 A;  1WGQ A;  2RNR B;  1OMW A;  2YSZ A;  2VRW B;  1SHC A;  4EMO A;  2D9Y A;  1M7E A;  3PSC A;  5C79 A;  2L2I A;  4GMV A;  2ROV A;  3ULB A;  1KZ7 A;  2M14 A;  1U27 A;  5C6R A;  1I2H A;  4HAY B;  2P8V A;  4OT1 A;  3F0W A;  2JP2 A;  1BTK A;  1UNP A;  4K17 A;  2DTC A;  3KZ1 A;  5D27 A;  5DHF B;  1FB8 A;  3AU5 A;  3GMU B;  5JHH A;  1V5P A;  3C7U B;  1W1D A;  1W1G A;  4D6W A;  1EGX A;  2DHI A;  3SO6 A;  1PMS A;  2P0F A;  4MY6 A;  1BAK A;  4WVF B;  2D9V A;  2LG1 A;  3NSU A;  1BTN A;  2K2J A;  3DXD A;  2COF A;  1JTG B;  2DHJ A;  1PFJ A;  3GYO A;  5J3Q A;  1TJ6 A;  1NI2 A;  4Z2N A;  3SUZ A;  1B55 A;  1X86 A;  2CAY A;  2Z13 A;  4GN1 A;  5CLL B;  1FHO A;  4TKN A;  2K00 A;  2COA A;  2ZPY A;  1P5T A;  2YF0 A;  3QBV B;  2AEH A;  1ISN A;  2ZKM X;  3PVW A;  4GXB A;  2B5R C;  3PZD A;  2P0D A;  1U5F A;  5M4Y B;  1T77 A;  1W1H A;  2YRY A;  2R09 A; 
#chains in the Genus database with same CATH homology
 2K8E A;  2Z4D A;  3A58 A;  4KHO A;  3FSS A;  2K49 A;  5EKQ E;  3OHM B;  4L1R A;  5I2M A;  3E2L C;  5IRS A;  4KHB A;  4GOU A;  3TO1 A;  3U12 A;  2KUQ A;  3GYP A;  3NWA A;  2G2W B;  2G2U B;  2FJU B;  3C7V B;  3TW1 A;  4QJ4 B;  4HSI A;  4CSQ A;  3NWF A;  4Z2M B;  5AYW E;  2Z59 A;  2GCL A;  3TVV A;  4KHB B;  4OT1 A;  2R2Y A;  2KXX A;  5I2S A;  1ZYI A;  3GMU B;  4DIX A;  3C7U B;  2KM7 A;  4D6W A;  4DM5 A;  3N4I B;  2YT2 A;  2KIG A;  2Z14 A;  3HIE A;  4IOY X;  3NWD A;  5LG4 B;  2KR0 A;  4OSN A;  1JTG B;  3FVC A;  4PQ0 A;  3NW8 A;  2GCJ A;  3GYO A;  5D0Q E;  4QJ5 B;  4Z2N A;  3E2K C;  3C4P B;  2RRF A;  1S0W C;  2GUM A;  2Z13 A;  4IFS A;  5D0O E;  1XXM C;  4QXA B;  2NBV A;  4QJ3 B;  2ZKM X;  2PXG A;  2KIE A;  2B5R C;  3C4O B;  4GNK B;  2YH9 A;  5M4Y B;  4KHA A;  3D4E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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