4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Viral protein
molecule keywords Envelope glycoprotein B
publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
source organism Human herpesvirus 1
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
3NWDA 4L1RA 3NWFA 3FVCA 3NWAA 3NW8A 4OSNA 4OT1A 2GUMA 4HSIA
chains in the Genus database with same CATH superfamily
4D0NB 1PLSA 1N3HA 2OTXA 2D10A 3BINA 2Z13A 4TYZA 2ROZB 4HB3B 4A6FB 1TQZA 2ZPYA 3A8QA 2X18A 5DHFB 2CAYA 1BTNA 3RCPA 5JHGA 1LB1A 1EGXA 3KY9A 4HAVB 3U12A 1XR0B 1MIXA 1XXMC 3KSYA 1ISNA 2DYQA 1FAOA 1X86A 2GCJA 1X05A 3TVVA 1BTKA 4WSFA 3SNHA 4HB0B 2K2JA 5C5BB 3C7UB 4MY6A 2UZSA 1WVHA 3DCXA 4HB4B 1NTVA 2QKLA 5HE0A 2E2XA 3D8FA 3CIKA 5D27A 5LONB 2DX1A 2J0KA 1M7EA 1AWEA 2DKQA 1V5MA 4OT1A 1UPQA 4KAXB 2D9XA 5D3XA 4F7GA 1V88A 1MAIA 2P0DA 3TCAA 2D9YA 5KQ1A 2D9ZA 2GUMA 1XODA 2Z0PA 2HTHB 2MFQA 4DM5A 1RRPB 5JHHA 2LKOA 3GYPA 2OQBA 1JTGB 1KZGA 4WJ7A 3ULCA 5CLQB 1GC7A 5JP4A 2J59M 3KRXA 5HE1A 1Y5OA 4Z2NA 3QBVB 2BCJA 2D4QA 3T06A 5C16A 2COAA 5J3QA 3NW8A 3N4IB 3C7VB 2YSZA 1UNQA 2K2UA 3A98B 1U5FA 2P8VA 1RJ2A 2DN6A 4MK0A 5KQ4A 2J0MA 3B77A 4WVFB 4A6HA 4CYEA 2DKPA 1MIZB 4DIXA 2K8EA 3FSSA 1Y19B 1FGZA 2YVCA 3D8EA 4KVGB 2UVMA 5C6RA 4HAWB 5DHAB 3LJUX 5DH9B 3HSAA 3O96A 3QIJA 4D6WA 3WYFB 3U8ZA 3ZDTA 3ULBA 1DDMA 2RVBB 4KHBA 2RNRB 2I1KA 2Q13A 3PEGA 2CODA 4CSQA 3NWAA 1U29A 2D9WA 4H8SA 1H10A 2DHIA 3SO6A 1FHWA 5JLJB 4PQ0A 2IFSA 3DXCA 5LG4B 2RGNB 1EF1A 3PP2A 3A8PA 4HAUB 2G2WB 1SHCA 1W1GA 1S0WC 5CLLB 3HQCA 4CHMA 2YH9A 3TO1A 1U5DA 2KUQA 1EAZA 1LW3A 4KHOA 5AYWE 1ZM0A 1UNPA 1WGUA 2Z4DA 2IYBA 2Z0OA 1QC6A 1QQGA 1WJ1A 3FM8C 1W1DA 1ZVRA 3NWDA 4YONA 4DX90 2RLOA 2L1CA 4XWXA 3CXBB 2CY5A 4IFSA 2EMTA 4EKUA 3G9WA 4K17A 1I2HA 2PZ1A 1BWNA 2N23A 1NI2A 5J3TA 2D2QA 1J0WA 5J3YA 4HDQA 4HATB 4F7UP 4ZRKA 3E2LC 1EVHA 2LULA 2L2IA 4KHAA 1MK7B 2RSGA 1OY2A 4HHVA 1P6SA 1OQNA 3HW2B 4QXAB 2D9VA 5HE3A 2K00A 1TXDA 1UNRA 5KCVA 1MPHA 3WA0A 2KM7A 4C0AA 4YL8A 5D0QE 2KCJA 2G35A 3PVLA 4BBKA 2PXGA 1T77A 2I5CA 2CRFA 3PZDA 4NSWA 4OSNA 2N0YA 1WGQA 4GZUA 2Y8FA 1H4RA 3AU5A 2YT0A 2R0DA 3MDBC 3P6AA 2R2YA 4GN1A 2YS1A 4L6EA 2Z0QA 3C4PB 2P0HA 2LG1A 4GXBA 2FJUB 1ZYIA 2EMSA 3SUZA 1BAKA 2GS0A 3UZTA 2MWNB 2LOXA 3NWFA 3HK0A 5D3YA 1MK9B 3A58A 2M14A 3C4OB 3N7CA 3ODXA 2QKMA 1MKEA 3E2KC 3AU4A 3V5WA 3AJ4A 1OMWA 3SV1A 4DBBA 2ELBA 5I2SA 1DYNA 3QWMA 2NMBA 2H7EA 1P5TA 3NSUA 1FGYA 4HAXB 2DYNA 2ROVA 2YS3A 4GMVA 2DHJA 2Y7BA 2KR0A 3FVCA 4IAPA 4NY0A 1Q67A 2ZKMX 4A6FA 1J19A 4TKNA 2GJYA 1NU2A 1NTYA 2KUPA 1FB8A 3U7DA 2EJ8A 2VSZA 5D3WA 4HAYB 4KHBB 2KXXA 2YT1A 5D0OE 5HE2A 1V5PA 2P0FA 3DXDA 3VOQA 3KRWA 3M1IB 1W1HA 2AL6A 2I5FA 2KIEA 1DDVA 2DTCA 5C5BA 3OHMB 4MT7A 2GCLA 1GG3A 3F5RA 1XD4A 2DHKA 5FI0A 1V61A 5L81A 2COCA 2VRWB 1ZC3B 1X11A 4L1RA 2NBVA 4Y94A 1ZSQA 1K5GB 3ODWA 5EKQE 1P3RA 4A5KA 2XQNM 2YRYA 1PMSA 4P7IA 1ZC4B 5LOPB 3PVUA 1UPRA 1K5DB 2YF0A 4QJ5B 1FHOA 2KGXB 1Z87A 5EFXA 4A6KA 1X1FA 2H7DA 2COFA 2Z59A 3P7ZA 1U5GA 4Z2MB 2Z14A 1DDWA 2DX5A 2I1JA 3GMUB 4QJ4B 5C79A 2W2WA 2M38A 4HDOA 1IRSA 1M7RA 4IOYX 5FI1A 1V89A 2NZ8B 2DFKA 3IVFA 4ZRJA 4ZRIA 1E5WA 1MI1A 1DROA 3MPXA 1KI1B 1U27A 2G2UB 2JP2A 2V76A 2RRFA 2RUKB 2ADZA 3OANA 1AQCA 3PSCA 3TW1A 4DXAB 2DA0A 4B6HA 4PNKA 2B5RC 3FEHA 2HE7A 2ELAA 1KZ7A 2W2XD 1V5UA 5GOWB 1PFJA 1X1GA 2KIGA 1U2BA 3GYOA 4GMXB 1XCGA 2YT2A 3KZ1A 4GPTB 5DI9B 3ZVRA 2UZRA 1WJMA 4HB2B 4GOUA 4F7HA 2FJLA 3BJIA 3PVWA 4GNKB 4K2OA 4K2PA 5DIFB 3ML4A 1WG7A 5I2MA 2AEHA 5M4YB 3DXEA 4DX8A 2CY4A 2D11A 3F0WA 1WI1A 2K49A 2LYDA 1U5EA 5D3VA 1XKEA 2YS5A 2Y8GA 3D8DA 3SYXA 3VIAA 3ODOA 1SGHA 3D4EA 4EJNA 1GC6A 2MKRA 3X23A 2W2XC 1TJ6A 4QJ3B 1XX0A 2LOZA 4HAZB 4CHJA 1DBHA 4K81A 1I7AA 2MDXA 5IRSA 2J0JA 3HIEA 1B55A 1FOEA 2VKIA 2DLWA 3PG7A 3TFMA 4HSIA 1FHXA 2R09A 2EC1A 1UEFA 4EMOA
chains in the Genus database with same CATH topology
4DIXA 2K8EA 3FSSA 4OSNA 2Z13A 4QJ5B 2R2YA 2Z59A 4D6WA 3C4PB 4Z2MB 3U12A 2Z14A 2FJUB 3GMUB 4QJ4B 1ZYIA 1XXMC 2GCJA 4KHBA 3TVVA 3C7UB 4IOYX 3NWFA 4CSQA 3NWAA 3A58A 3C4OB 2G2UB 2RRFA 4PQ0A 5LG4B 3E2KC 3TW1A 2G2WB 2B5RC 4OT1A 1S0WC 2YH9A 3TO1A 2KIGA 2KUQA 4KHOA 5I2SA 3GYOA 5AYWE 2Z4DA 2YT2A 4GOUA 3NWDA 4GNKB 2KR0A 3FVCA 4IFSA 2GUMA 2ZKMX 5I2MA 4DM5A 5M4YB 3GYPA 1JTGB 5D0OE 4KHBB 2KXXA 2K49A 3E2LC 2KIEA 4KHAA 3OHMB 4Z2NA 3D4EA 4QXAB 2GCLA 3NW8A 4QJ3B 3N4IB 3C7VB 5IRSA 2KM7A 3HIEA 4HSIA 5D0QE 4L1RA 2NBVA 2PXGA 5EKQE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NWD A;  4L1R A;  3NWF A;  3FVC A;  3NWA A;  3NW8 A;  4OSN A;  4OT1 A;  2GUM A;  4HSI A; 
#chains in the Genus database with same CATH topology
 4D0N B;  1PLS A;  1N3H A;  2OTX A;  2D10 A;  3BIN A;  2Z13 A;  4TYZ A;  2ROZ B;  4HB3 B;  4A6F B;  1TQZ A;  2ZPY A;  3A8Q A;  2X18 A;  5DHF B;  2CAY A;  1BTN A;  3RCP A;  5JHG A;  1LB1 A;  1EGX A;  3KY9 A;  4HAV B;  3U12 A;  1XR0 B;  1MIX A;  1XXM C;  3KSY A;  1ISN A;  2DYQ A;  1FAO A;  1X86 A;  2GCJ A;  1X05 A;  3TVV A;  1BTK A;  4WSF A;  3SNH A;  4HB0 B;  2K2J A;  5C5B B;  3C7U B;  4MY6 A;  2UZS A;  1WVH A;  3DCX A;  4HB4 B;  1NTV A;  2QKL A;  5HE0 A;  2E2X A;  3D8F A;  3CIK A;  5D27 A;  5LON B;  2DX1 A;  2J0K A;  1M7E A;  1AWE A;  2DKQ A;  1V5M A;  4OT1 A;  1UPQ A;  4KAX B;  2D9X A;  5D3X A;  4F7G A;  1V88 A;  1MAI A;  2P0D A;  3TCA A;  2D9Y A;  5KQ1 A;  2D9Z A;  2GUM A;  1XOD A;  2Z0P A;  2HTH B;  2MFQ A;  4DM5 A;  1RRP B;  5JHH A;  2LKO A;  3GYP A;  2OQB A;  1JTG B;  1KZG A;  4WJ7 A;  3ULC A;  5CLQ B;  1GC7 A;  5JP4 A;  2J59 M;  3KRX A;  5HE1 A;  1Y5O A;  4Z2N A;  3QBV B;  2BCJ A;  2D4Q A;  3T06 A;  5C16 A;  2COA A;  5J3Q A;  3NW8 A;  3N4I B;  3C7V B;  2YSZ A;  1UNQ A;  2K2U A;  3A98 B;  1U5F A;  2P8V A;  1RJ2 A;  2DN6 A;  4MK0 A;  5KQ4 A;  2J0M A;  3B77 A;  4WVF B;  4A6H A;  4CYE A;  2DKP A;  1MIZ B;  4DIX A;  2K8E A;  3FSS A;  1Y19 B;  1FGZ A;  2YVC A;  3D8E A;  4KVG B;  2UVM A;  5C6R A;  4HAW B;  5DHA B;  3LJU X;  5DH9 B;  3HSA A;  3O96 A;  3QIJ A;  4D6W A;  3WYF B;  3U8Z A;  3ZDT A;  3ULB A;  1DDM A;  2RVB B;  4KHB A;  2RNR B;  2I1K A;  2Q13 A;  3PEG A;  2COD A;  4CSQ A;  3NWA A;  1U29 A;  2D9W A;  4H8S A;  1H10 A;  2DHI A;  3SO6 A;  1FHW A;  5JLJ B;  4PQ0 A;  2IFS A;  3DXC A;  5LG4 B;  2RGN B;  1EF1 A;  3PP2 A;  3A8P A;  4HAU B;  2G2W B;  1SHC A;  1W1G A;  1S0W C;  5CLL B;  3HQC A;  4CHM A;  2YH9 A;  3TO1 A;  1U5D A;  2KUQ A;  1EAZ A;  1LW3 A;  4KHO A;  5AYW E;  1ZM0 A;  1UNP A;  1WGU A;  2Z4D A;  2IYB A;  2Z0O A;  1QC6 A;  1QQG A;  1WJ1 A;  3FM8 C;  1W1D A;  1ZVR A;  3NWD A;  4YON A;  4DX9 0;  2RLO A;  2L1C A;  4XWX A;  3CXB B;  2CY5 A;  4IFS A;  2EMT A;  4EKU A;  3G9W A;  4K17 A;  1I2H A;  2PZ1 A;  1BWN A;  2N23 A;  1NI2 A;  5J3T A;  2D2Q A;  1J0W A;  5J3Y A;  4HDQ A;  4HAT B;  4F7U P;  4ZRK A;  3E2L C;  1EVH A;  2LUL A;  2L2I A;  4KHA A;  1MK7 B;  2RSG A;  1OY2 A;  4HHV A;  1P6S A;  1OQN A;  3HW2 B;  4QXA B;  2D9V A;  5HE3 A;  2K00 A;  1TXD A;  1UNR A;  5KCV A;  1MPH A;  3WA0 A;  2KM7 A;  4C0A A;  4YL8 A;  5D0Q E;  2KCJ A;  2G35 A;  3PVL A;  4BBK A;  2PXG A;  1T77 A;  2I5C A;  2CRF A;  3PZD A;  4NSW A;  4OSN A;  2N0Y A;  1WGQ A;  4GZU A;  2Y8F A;  1H4R A;  3AU5 A;  2YT0 A;  2R0D A;  3MDB C;  3P6A A;  2R2Y A;  4GN1 A;  2YS1 A;  4L6E A;  2Z0Q A;  3C4P B;  2P0H A;  2LG1 A;  4GXB A;  2FJU B;  1ZYI A;  2EMS A;  3SUZ A;  1BAK A;  2GS0 A;  3UZT A;  2MWN B;  2LOX A;  3NWF A;  3HK0 A;  5D3Y A;  1MK9 B;  3A58 A;  2M14 A;  3C4O B;  3N7C A;  3ODX A;  2QKM A;  1MKE A;  3E2K C;  3AU4 A;  3V5W A;  3AJ4 A;  1OMW A;  3SV1 A;  4DBB A;  2ELB A;  5I2S A;  1DYN A;  3QWM A;  2NMB A;  2H7E A;  1P5T A;  3NSU A;  1FGY A;  4HAX B;  2DYN A;  2ROV A;  2YS3 A;  4GMV A;  2DHJ A;  2Y7B A;  2KR0 A;  3FVC A;  4IAP A;  4NY0 A;  1Q67 A;  2ZKM X;  4A6F A;  1J19 A;  4TKN A;  2GJY A;  1NU2 A;  1NTY A;  2KUP A;  1FB8 A;  3U7D A;  2EJ8 A;  2VSZ A;  5D3W A;  4HAY B;  4KHB B;  2KXX A;  2YT1 A;  5D0O E;  5HE2 A;  1V5P A;  2P0F A;  3DXD A;  3VOQ A;  3KRW A;  3M1I B;  1W1H A;  2AL6 A;  2I5F A;  2KIE A;  1DDV A;  2DTC A;  5C5B A;  3OHM B;  4MT7 A;  2GCL A;  1GG3 A;  3F5R A;  1XD4 A;  2DHK A;  5FI0 A;  1V61 A;  5L81 A;  2COC A;  2VRW B;  1ZC3 B;  1X11 A;  4L1R A;  2NBV A;  4Y94 A;  1ZSQ A;  1K5G B;  3ODW A;  5EKQ E;  1P3R A;  4A5K A;  2XQN M;  2YRY A;  1PMS A;  4P7I A;  1ZC4 B;  5LOP B;  3PVU A;  1UPR A;  1K5D B;  2YF0 A;  4QJ5 B;  1FHO A;  2KGX B;  1Z87 A;  5EFX A;  4A6K A;  1X1F A;  2H7D A;  2COF A;  2Z59 A;  3P7Z A;  1U5G A;  4Z2M B;  2Z14 A;  1DDW A;  2DX5 A;  2I1J A;  3GMU B;  4QJ4 B;  5C79 A;  2W2W A;  2M38 A;  4HDO A;  1IRS A;  1M7R A;  4IOY X;  5FI1 A;  1V89 A;  2NZ8 B;  2DFK A;  3IVF A;  4ZRJ A;  4ZRI A;  1E5W A;  1MI1 A;  1DRO A;  3MPX A;  1KI1 B;  1U27 A;  2G2U B;  2JP2 A;  2V76 A;  2RRF A;  2RUK B;  2ADZ A;  3OAN A;  1AQC A;  3PSC A;  3TW1 A;  4DXA B;  2DA0 A;  4B6H A;  4PNK A;  2B5R C;  3FEH A;  2HE7 A;  2ELA A;  1KZ7 A;  2W2X D;  1V5U A;  5GOW B;  1PFJ A;  1X1G A;  2KIG A;  1U2B A;  3GYO A;  4GMX B;  1XCG A;  2YT2 A;  3KZ1 A;  4GPT B;  5DI9 B;  3ZVR A;  2UZR A;  1WJM A;  4HB2 B;  4GOU A;  4F7H A;  2FJL A;  3BJI A;  3PVW A;  4GNK B;  4K2O A;  4K2P A;  5DIF B;  3ML4 A;  1WG7 A;  5I2M A;  2AEH A;  5M4Y B;  3DXE A;  4DX8 A;  2CY4 A;  2D11 A;  3F0W A;  1WI1 A;  2K49 A;  2LYD A;  1U5E A;  5D3V A;  1XKE A;  2YS5 A;  2Y8G A;  3D8D A;  3SYX A;  3VIA A;  3ODO A;  1SGH A;  3D4E A;  4EJN A;  1GC6 A;  2MKR A;  3X23 A;  2W2X C;  1TJ6 A;  4QJ3 B;  1XX0 A;  2LOZ A;  4HAZ B;  4CHJ A;  1DBH A;  4K81 A;  1I7A A;  2MDX A;  5IRS A;  2J0J A;  3HIE A;  1B55 A;  1FOE A;  2VKI A;  2DLW A;  3PG7 A;  3TFM A;  4HSI A;  1FHX A;  2R09 A;  2EC1 A;  1UEF A;  4EMO A; 
#chains in the Genus database with same CATH homology
 4DIX A;  2K8E A;  3FSS A;  4OSN A;  2Z13 A;  4QJ5 B;  2R2Y A;  2Z59 A;  4D6W A;  3C4P B;  4Z2M B;  3U12 A;  2Z14 A;  2FJU B;  3GMU B;  4QJ4 B;  1ZYI A;  1XXM C;  2GCJ A;  4KHB A;  3TVV A;  3C7U B;  4IOY X;  3NWF A;  4CSQ A;  3NWA A;  3A58 A;  3C4O B;  2G2U B;  2RRF A;  4PQ0 A;  5LG4 B;  3E2K C;  3TW1 A;  2G2W B;  2B5R C;  4OT1 A;  1S0W C;  2YH9 A;  3TO1 A;  2KIG A;  2KUQ A;  4KHO A;  5I2S A;  3GYO A;  5AYW E;  2Z4D A;  2YT2 A;  4GOU A;  3NWD A;  4GNK B;  2KR0 A;  3FVC A;  4IFS A;  2GUM A;  2ZKM X;  5I2M A;  4DM5 A;  5M4Y B;  3GYP A;  1JTG B;  5D0O E;  4KHB B;  2KXX A;  2K49 A;  3E2L C;  2KIE A;  4KHA A;  3OHM B;  4Z2N A;  3D4E A;  4QXA B;  2GCL A;  3NW8 A;  4QJ3 B;  3N4I B;  3C7V B;  5IRS A;  2KM7 A;  3HIE A;  4HSI A;  5D0Q E;  4L1R A;  2NBV A;  2PXG A;  5EKQ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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