4Y94A

Crystal structure of the ph-th module of bruton's tyrosine kinase bound to inositol hexakisphosphate
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
167
structure length
158
Chain Sequence
ATVILESIFLKRSSPLNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPEESSETEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQIL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
pubmed doi rcsb
molecule keywords Non-specific protein-tyrosine kinase
molecule tags Transferase
source organism Bos taurus
total genus 28
structure length 158
sequence length 167
chains with identical sequence B, C, D
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2015-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00169 PH PH domain
A PF00779 BTK BTK motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.30 Mainly Beta Roll PH-domain like Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 4y94A00
2L2IA 2RLOA 4K17A 2LG1A 2KCJA 1XX0A 1RRPB 1ZC3B 4ZRKA 3IVFA 4GXBA 3A98B 3LJUX 2D9WA 2IYBA 4K81A 4WVFB 5HE2A 4GMVA 5CLLB 2EJ8A 1WVHA 1EF1A 4KAXB 5FI0A 1V5UA 1SHCA 3ML4A 1E5WA 2D9ZA 2CY5A 4WSFA 4XWXA 2I1KA 3PG7A 3F0WA 2YRYA 2RVBB 1GG3A 2OQBA 3PEGA 2E2XA 5DHAB 1X1FA 4YONA 2Q13A 2DKPA 3QIJA 2P8VA 2HE7A 1XCGA 3TW1A 1BAKA 3ODXA 1KI1B 1FOEA 2EMSA 4H8SA 2NZ8B 5DHFB 2RSGA 1UNPA 1TJ6A 5D3XA 2VSZA 1Y19B 2COCA 2MKRA 2D2QA 4D0NB 1DDVA 3N7CA 2ADZA 1XD4A 2LOZA 4Y94A 3QWMA 5D3WA 5D3VA 1ISNA 5L81A 1PFJA 3O96A 3ODOA 5J3QA 1J19A 3WA0A 3FSSA 3AU5A 2K2UA 2FJLA 3KY9A 3PSCA 1U5GA 1XKEA 4YL8A 4HB3B 4HDOA 2Y7BA 2CODA 2N23A 1M7EA 1OMWA 3ULCA 5HE1A 2W2XD 2DX5A 3T06A 4GN1A 4EKUA 1FHXA 2DA0A 5C16A 1B55A 1DDWA 4CYEA 2W2XC 4KHAA 2GS0A 1DROA 2M14A 1K5DB 3KZ1A 2D9XA 1H4RA 4Z2MB 3D8EA 2I5FA 2DX1A 1AWEA 1ZSQA 2YT0A 5DI9B 3HW2B 1IRSA 1X05A 2R09A 3PVLA 1P6SA 4NSWA 1WI1A 4KHOA 2I1JA 1XODA 3RCPA 3A8QA 3ZVRA 1ZVRA 2PZ1A 2W2WA 3GYPA 1GC7A 1WJMA 1M7RA 1U5FA 1I7AA 1W1DA 2J0MA 2AL6A 5C5BB 2GJYA 1Z87A 1V88A 2K2JA 5C6RA 2X18A 4HB4B 3UZTA 2CRFA 5GOWB 3A8PA 5JP4A 1FHWA 2GCLA 4F7HA 4HAZB 3DXDA 4DX8A 2DHJA 1UNQA 3SO6A 4DBBA 5J3TA 2I5CA 3U8ZA 4HB2B 4MT7A 1ZM0A 2LKOA 4C0AA 4HAWB 2GCJA 3TCAA 2UZRA 2M38A 1WJ1A 2DHKA 1U29A 2ELAA 1DBHA 2DYNA 4PNKA 3MPXA 3PVUA 1U5DA 3BINA 2Y8FA 1TQZA 2KUPA 3G9WA 2YT1A 1X86A 1V89A 4HAVB 4P7IA 1KZ7A 2VKIA 3AJ4A 1RJ2A 3PVWA 5HE0A 1PLSA 3GYOA 2D9VA 1X11A 2J0JA 5EFXA 4MK0A 5LONB 3BJIA 1LB1A 4A6FA 1SGHA 1K5GB 2HTHB 1MIZB 3F5RA 2MFQA 3VIAA 3P7ZA 3V5WA 1U2BA 1OY2A 1OQNA 1FGYA 1QQGA 2P0DA 3DXCA 2H7DA 2RUKB 2Y8GA 2J59M 4A5KA 4EJNA 5C5BA 2NMBA 2RNRB 2IFSA 3PZDA 3KRXA 2LOXA 2DKQA 4IFSA 4A6HA 3FEHA 1BTKA 1Y5OA 1UNRA 2CAYA 2ZPYA 4DXAB 1DYNA 2YS1A 4KHBB 4TYZA 1Q67A 2P0FA 5KQ4A 4A6FB 3SUZA 1MK7B 1I2HA 1FB8A 1MPHA 1J0WA 1PMSA 3QBVB 1NTYA 2MDXA 1BTNA 4IAPA 3WYFB 5JLJB 4KVGB 2N0YA 4B6HA 5DH9B 1WGUA 5KQ1A 2R0DA 3CXBB 2G35A 4PQ0A 3KSYA 1UPQA 5LOPB 3TVVA 1U27A 4CHMA 4BBKA 2DHIA 2XQNM 3TO1A 2COAA 3TFMA 4EMOA 2YS3A 4HHVA 1MKEA 2D4QA 1N3HA 2DFKA 1QC6A 2RGNB 1KZGA 1ZC4B 4NY0A 2H7EA 3SYXA 2J0KA 1P5TA 3P6AA 1MAIA 4F7GA 3D8DA 4GPTB 4A6KA 4GZUA 3FM8C 1MK9B 4F7UP 2L1CA 1XR0B 4TKNA 4ZRIA 2QKMA 1NI2A 2DN6A 5JHHA 1W1HA 3NSUA 1AQCA 1NTVA 1X1GA 5JHGA 3ZDTA 1U5EA 3DXEA 1FGZA 1UEFA 3SV1A 3KRWA 2CY4A 1H10A 2UZSA 5C79A 1DDMA 1WGQA 2LYDA 2YS5A 1P3RA 2EC1A 2VRWB 3U7DA 2V76A 5CLQB 3ULBA 2BCJA 4HAXB 4K2OA 2YSZA 4IOYX 3AU4A 4ZRJA 1EGXA 5D27A 1EAZA 2UVMA 5FI1A 1V61A 4HATB 5D3YA 1BWNA 2D10A 2DTCA 2QKLA 4DX90 1UPRA 4K2PA 2P0HA 1MIXA 3PP2A 2KGXB 5KCVA 2K00A 5DIFB 2COFA 3M1IB 2DYQA 5J3YA 2LULA 2EMTA 3ODWA 2D11A 3HQCA 4HAYB 1WG7A 1LW3A 2Z0PA 3VOQA 2MWNB 3OANA 3HK0A 4GMXB 3X23A 2OTXA 2D9YA 1EVHA 2Z0OA 1NU2A 1V5PA 4HDQA 4HB0B 1V5MA 1GC6A 2Z0QA 1W1GA 2ROZB 4L6EA 2DLWA 3SNHA 4Z2NA 4HAUB 5HE3A 2YVCA 3CIKA 2ROVA 4MY6A 2AEHA 4WJ7A 3MDBC 1FHOA 2YF0A 4CHJA 3D8FA 1TXDA 2ELBA 2JP2A 1FAOA
chains in the Genus database with same CATH superfamily
2L2IA 2RLOA 4K17A 2LG1A 2KCJA 1XX0A 1RRPB 1ZC3B 4ZRKA 3IVFA 4GXBA 3A98B 3LJUX 2D9WA 2IYBA 4K81A 4WVFB 5HE2A 4GMVA 5CLLB 2EJ8A 1WVHA 1EF1A 4QJ3B 4KAXB 5FI0A 1V5UA 4QJ5B 1SHCA 3ML4A 1E5WA 2D9ZA 2CY5A 4WSFA 4XWXA 2K8EA 2I1KA 3PG7A 3F0WA 2YRYA 2RVBB 1GG3A 2OQBA 3PEGA 2E2XA 5DHAB 1X1FA 4YONA 2Q13A 2DKPA 3QIJA 4DIXA 2P8VA 2HE7A 1XCGA 3TW1A 1BAKA 3ODXA 1KI1B 1FOEA 2EMSA 4H8SA 2NZ8B 5DHFB 2RSGA 1UNPA 1TJ6A 5D3XA 2VSZA 1Y19B 2COCA 2K49A 2MKRA 2D2QA 4D0NB 1DDVA 3N7CA 2ADZA 1XD4A 2LOZA 4Y94A 3QWMA 5D3WA 5D3VA 1ISNA 5L81A 1PFJA 3O96A 3ODOA 5J3QA 1J19A 3WA0A 2KR0A 3FSSA 3AU5A 2K2UA 2FJLA 3B77A 3KY9A 3PSCA 1U5GA 1XKEA 4YL8A 4HB3B 4HDOA 4OSNA 2Y7BA 2CODA 2N23A 1M7EA 1OMWA 3ULCA 5HE1A 2W2XD 2DX5A 3T06A 4GN1A 5LG4B 4EKUA 1FHXA 2DA0A 5C16A 1B55A 1DDWA 3OHMB 4CYEA 2W2XC 4KHAA 2GS0A 1DROA 4GOUA 2M14A 1K5DB 3KZ1A 2D9XA 1H4RA 4Z2MB 3D8EA 2I5FA 2DX1A 1AWEA 4QXAB 1ZSQA 2YT0A 5DI9B 3HW2B 1IRSA 1X05A 2R09A 3PVLA 1P6SA 4NSWA 1WI1A 4KHOA 2I1JA 1XODA 3RCPA 3A8QA 5I2MA 3NWDA 3ZVRA 1ZVRA 2PZ1A 3NW8A 2W2WA 2ZKMX 3GYPA 1GC7A 1WJMA 2FJUB 1M7RA 3U12A 1U5FA 1I7AA 1W1DA 2J0MA 2AL6A 5C5BB 2GJYA 1Z87A 1V88A 2K2JA 5C6RA 3DCXA 2X18A 4HB4B 3UZTA 2CRFA 5GOWB 3A8PA 5JP4A 1FHWA 2GCLA 4F7HA 4HAZB 3DXDA 4DX8A 2DHJA 1UNQA 5IRSA 3SO6A 4DBBA 5J3TA 2I5CA 3U8ZA 2GUMA 3A58A 4HB2B 4MT7A 1ZM0A 2LKOA 4C0AA 4HAWB 2GCJA 3TCAA 2UZRA 2M38A 2YT2A 1WJ1A 2DHKA 1U29A 2ELAA 1DBHA 5I2SA 2DYNA 4PNKA 3MPXA 3PVUA 1U5DA 3BINA 2Y8FA 1TQZA 2KUPA 3G9WA 2YT1A 1X86A 1V89A 4HAVB 4P7IA 4GNKB 1KZ7A 2Z14A 2VKIA 5M4YB 3HSAA 3AJ4A 1RJ2A 3PVWA 5HE0A 1PLSA 3GYOA 2D9VA 1X11A 2J0JA 5EFXA 4MK0A 5LONB 3NWAA 3BJIA 1LB1A 4A6FA 1SGHA 1K5GB 2HTHB 1MIZB 3F5RA 2MFQA 3VIAA 3P7ZA 3V5WA 1U2BA 1OY2A 1OQNA 1FGYA 1QQGA 2P0DA 3DXCA 2H7DA 2RUKB 2Y8GA 2J59M 4A5KA 4EJNA 5C5BA 2NMBA 2RNRB 2IFSA 3PZDA 3KRXA 2LOXA 2DKQA 4IFSA 4A6HA 3FEHA 1BTKA 1Y5OA 1UNRA 2CAYA 2ZPYA 4DXAB 1DYNA 2YS1A 4KHBB 4TYZA 1Q67A 2P0FA 5KQ4A 4A6FB 3SUZA 1MK7B 3FVCA 1I2HA 1FB8A 1MPHA 1J0WA 1PMSA 3QBVB 1NTYA 1MI1A 2MDXA 1BTNA 4IAPA 3WYFB 5JLJB 4KVGB 1ZYIA 2N0YA 4B6HA 2Z4DA 5DH9B 1WGUA 5KQ1A 2R0DA 3CXBB 2G35A 4PQ0A 3KSYA 1UPQA 5LOPB 3TVVA 3NWFA 2Z59A 1U27A 4CHMA 4BBKA 2DHIA 2XQNM 3TO1A 2COAA 3TFMA 4EMOA 2YS3A 4HHVA 1MKEA 2D4QA 1N3HA 2DFKA 2RRFA 2R2YA 1QC6A 2RGNB 1KZGA 1ZC4B 4NY0A 2H7EA 3SYXA 2J0KA 4QJ4B 1P5TA 3P6AA 1MAIA 4F7GA 3D8DA 4GPTB 4A6KA 2KUQA 4GZUA 3FM8C 1MK9B 4F7UP 2L1CA 1XR0B 4TKNA 4ZRIA 2QKMA 1NI2A 2DN6A 5JHHA 1W1HA 3NSUA 1AQCA 1NTVA 1X1GA 5JHGA 3ZDTA 1U5EA 3DXEA 1FGZA 1UEFA 3SV1A 3KRWA 2CY4A 1H10A 4KHBA 2UZSA 5C79A 1DDMA 1WGQA 2LYDA 2YS5A 1P3RA 2EC1A 2NBVA 2VRWB 3U7DA 2V76A 5CLQB 2Z13A 2BCJA 3ULBA 4HAXB 4K2OA 2KIEA 2YSZA 4IOYX 3AU4A 4ZRJA 1EGXA 4HSIA 5D27A 1EAZA 2UVMA 5FI1A 1V61A 4HATB 5D3YA 4L1RA 1BWNA 2D10A 4CSQA 2DTCA 2QKLA 4DX90 1UPRA 4K2PA 2P0HA 1MIXA 3PP2A 2KGXB 5KCVA 2K00A 5DIFB 2COFA 3M1IB 2DYQA 5J3YA 2LULA 2EMTA 3ODWA 2D11A 3HQCA 4HAYB 1WG7A 1LW3A 2KIGA 2Z0PA 3VOQA 2MWNB 3OANA 3HK0A 4GMXB 3X23A 2OTXA 2D9YA 1EVHA 2Z0OA 1NU2A 1V5PA 1T77A 4HDQA 4HB0B 1V5MA 1GC6A 2Z0QA 1W1GA 2ROZB 4L6EA 4D6WA 2DLWA 3SNHA 4Z2NA 4HAUB 5HE3A 4OT1A 2YVCA 3CIKA 2ROVA 4MY6A 2AEHA 4WJ7A 3MDBC 1FHOA 2YF0A 3HIEA 4CHJA 3D8FA 1TXDA 2ELBA 2JP2A 1FAOA
chains in the Genus database with same CATH topology
2L2IA 2RLOA 4K17A 2LG1A 2KCJA 1XX0A 1RRPB 1ZC3B 4ZRKA 3IVFA 4GXBA 3A98B 3LJUX 2D9WA 2IYBA 4K81A 4WVFB 5HE2A 4GMVA 5CLLB 2EJ8A 1WVHA 1EF1A 4KAXB 5FI0A 1V5UA 1SHCA 3ML4A 1E5WA 2D9ZA 2CY5A 4WSFA 4XWXA 2I1KA 3PG7A 3F0WA 2YRYA 2RVBB 1GG3A 2OQBA 3PEGA 2E2XA 5DHAB 1X1FA 4YONA 2Q13A 2DKPA 3QIJA 2P8VA 2HE7A 1XCGA 3TW1A 1BAKA 3ODXA 1KI1B 1FOEA 2EMSA 4H8SA 2NZ8B 5DHFB 2RSGA 1UNPA 1TJ6A 5D3XA 2VSZA 1Y19B 2COCA 2MKRA 2D2QA 4D0NB 1DDVA 3N7CA 2ADZA 1XD4A 2LOZA 4Y94A 3QWMA 5D3WA 5D3VA 1ISNA 5L81A 1PFJA 3O96A 3ODOA 5J3QA 1J19A 3WA0A 3FSSA 3AU5A 2K2UA 2FJLA 3KY9A 3PSCA 1U5GA 1XKEA 4YL8A 4HB3B 4HDOA 2Y7BA 2CODA 2N23A 1M7EA 1OMWA 3ULCA 5HE1A 2W2XD 2DX5A 3T06A 4GN1A 4EKUA 1FHXA 2DA0A 5C16A 1B55A 1DDWA 4CYEA 2W2XC 4KHAA 2GS0A 1DROA 2M14A 1K5DB 3KZ1A 2D9XA 1H4RA 4Z2MB 3D8EA 2I5FA 2DX1A 1AWEA 1ZSQA 2YT0A 5DI9B 3HW2B 1IRSA 1X05A 2R09A 3PVLA 1P6SA 4NSWA 1WI1A 4KHOA 2I1JA 1XODA 3RCPA 3A8QA 3ZVRA 1ZVRA 2PZ1A 2W2WA 3GYPA 1GC7A 1WJMA 1M7RA 1U5FA 1I7AA 1W1DA 2J0MA 2AL6A 5C5BB 2GJYA 1Z87A 1V88A 2K2JA 5C6RA 2X18A 4HB4B 3UZTA 2CRFA 5GOWB 3A8PA 5JP4A 1FHWA 2GCLA 4F7HA 4HAZB 3DXDA 4DX8A 2DHJA 1UNQA 3SO6A 4DBBA 5J3TA 2I5CA 3U8ZA 4HB2B 4MT7A 1ZM0A 2LKOA 4C0AA 4HAWB 2GCJA 3TCAA 2UZRA 2M38A 1WJ1A 2DHKA 1U29A 2ELAA 1DBHA 2DYNA 4PNKA 3MPXA 3PVUA 1U5DA 3BINA 2Y8FA 1TQZA 2KUPA 3G9WA 2YT1A 1X86A 1V89A 4HAVB 4P7IA 1KZ7A 2VKIA 3AJ4A 1RJ2A 3PVWA 5HE0A 1PLSA 3GYOA 2D9VA 1X11A 2J0JA 5EFXA 4MK0A 5LONB 3BJIA 1LB1A 4A6FA 1SGHA 1K5GB 2HTHB 1MIZB 3F5RA 2MFQA 3VIAA 3P7ZA 3V5WA 1U2BA 1OY2A 1OQNA 1FGYA 1QQGA 2P0DA 3DXCA 2H7DA 2RUKB 2Y8GA 2J59M 4A5KA 4EJNA 5C5BA 2NMBA 2RNRB 2IFSA 3PZDA 3KRXA 2LOXA 2DKQA 4IFSA 4A6HA 3FEHA 1BTKA 1Y5OA 1UNRA 2CAYA 2ZPYA 4DXAB 1DYNA 2YS1A 4KHBB 4TYZA 1Q67A 2P0FA 5KQ4A 4A6FB 3SUZA 1MK7B 1I2HA 1FB8A 1MPHA 1J0WA 1PMSA 3QBVB 1NTYA 2MDXA 1BTNA 4IAPA 3WYFB 5JLJB 4KVGB 2N0YA 4B6HA 5DH9B 1WGUA 5KQ1A 2R0DA 3CXBB 2G35A 4PQ0A 3KSYA 1UPQA 5LOPB 3TVVA 1U27A 4CHMA 4BBKA 2DHIA 2XQNM 3TO1A 2COAA 3TFMA 4EMOA 2YS3A 4HHVA 1MKEA 2D4QA 1N3HA 2DFKA 1QC6A 2RGNB 1KZGA 1ZC4B 4NY0A 2H7EA 3SYXA 2J0KA 1P5TA 3P6AA 1MAIA 4F7GA 3D8DA 4GPTB 4A6KA 4GZUA 3FM8C 1MK9B 4F7UP 2L1CA 1XR0B 4TKNA 4ZRIA 2QKMA 1NI2A 2DN6A 5JHHA 1W1HA 3NSUA 1AQCA 1NTVA 1X1GA 5JHGA 3ZDTA 1U5EA 3DXEA 1FGZA 1UEFA 3SV1A 3KRWA 2CY4A 1H10A 2UZSA 5C79A 1DDMA 1WGQA 2LYDA 2YS5A 1P3RA 2EC1A 2VRWB 3U7DA 2V76A 5CLQB 3ULBA 2BCJA 4HAXB 4K2OA 2YSZA 4IOYX 3AU4A 4ZRJA 1EGXA 5D27A 1EAZA 2UVMA 5FI1A 1V61A 4HATB 5D3YA 1BWNA 2D10A 2DTCA 2QKLA 4DX90 1UPRA 4K2PA 2P0HA 1MIXA 3PP2A 2KGXB 5KCVA 2K00A 5DIFB 2COFA 3M1IB 2DYQA 5J3YA 2LULA 2EMTA 3ODWA 2D11A 3HQCA 4HAYB 1WG7A 1LW3A 2Z0PA 3VOQA 2MWNB 3OANA 3HK0A 4GMXB 3X23A 2OTXA 2D9YA 1EVHA 2Z0OA 1NU2A 1V5PA 4HDQA 4HB0B 1V5MA 1GC6A 2Z0QA 1W1GA 2ROZB 4L6EA 2DLWA 3SNHA 4Z2NA 4HAUB 5HE3A 2YVCA 3CIKA 2ROVA 4MY6A 2AEHA 4WJ7A 3MDBC 1FHOA 2YF0A 4CHJA 3D8FA 1TXDA 2ELBA 2JP2A 1FAOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L2I A;  2RLO A;  4K17 A;  2LG1 A;  2KCJ A;  1XX0 A;  1RRP B;  1ZC3 B;  4ZRK A;  3IVF A;  4GXB A;  3A98 B;  3LJU X;  2D9W A;  2IYB A;  4K81 A;  4WVF B;  5HE2 A;  4GMV A;  5CLL B;  2EJ8 A;  1WVH A;  1EF1 A;  4KAX B;  5FI0 A;  1V5U A;  1SHC A;  3ML4 A;  1E5W A;  2D9Z A;  2CY5 A;  4WSF A;  4XWX A;  2I1K A;  3PG7 A;  3F0W A;  2YRY A;  2RVB B;  1GG3 A;  2OQB A;  3PEG A;  2E2X A;  5DHA B;  1X1F A;  4YON A;  2Q13 A;  2DKP A;  3QIJ A;  2P8V A;  2HE7 A;  1XCG A;  3TW1 A;  1BAK A;  3ODX A;  1KI1 B;  1FOE A;  2EMS A;  4H8S A;  2NZ8 B;  5DHF B;  2RSG A;  1UNP A;  1TJ6 A;  5D3X A;  2VSZ A;  1Y19 B;  2COC A;  2MKR A;  2D2Q A;  4D0N B;  1DDV A;  3N7C A;  2ADZ A;  1XD4 A;  2LOZ A;  4Y94 A;  3QWM A;  5D3W A;  5D3V A;  1ISN A;  5L81 A;  1PFJ A;  3O96 A;  3ODO A;  5J3Q A;  1J19 A;  3WA0 A;  3FSS A;  3AU5 A;  2K2U A;  2FJL A;  3KY9 A;  3PSC A;  1U5G A;  1XKE A;  4YL8 A;  4HB3 B;  4HDO A;  2Y7B A;  2COD A;  2N23 A;  1M7E A;  1OMW A;  3ULC A;  5HE1 A;  2W2X D;  2DX5 A;  3T06 A;  4GN1 A;  4EKU A;  1FHX A;  2DA0 A;  5C16 A;  1B55 A;  1DDW A;  4CYE A;  2W2X C;  4KHA A;  2GS0 A;  1DRO A;  2M14 A;  1K5D B;  3KZ1 A;  2D9X A;  1H4R A;  4Z2M B;  3D8E A;  2I5F A;  2DX1 A;  1AWE A;  1ZSQ A;  2YT0 A;  5DI9 B;  3HW2 B;  1IRS A;  1X05 A;  2R09 A;  3PVL A;  1P6S A;  4NSW A;  1WI1 A;  4KHO A;  2I1J A;  1XOD A;  3RCP A;  3A8Q A;  3ZVR A;  1ZVR A;  2PZ1 A;  2W2W A;  3GYP A;  1GC7 A;  1WJM A;  1M7R A;  1U5F A;  1I7A A;  1W1D A;  2J0M A;  2AL6 A;  5C5B B;  2GJY A;  1Z87 A;  1V88 A;  2K2J A;  5C6R A;  2X18 A;  4HB4 B;  3UZT A;  2CRF A;  5GOW B;  3A8P A;  5JP4 A;  1FHW A;  2GCL A;  4F7H A;  4HAZ B;  3DXD A;  4DX8 A;  2DHJ A;  1UNQ A;  3SO6 A;  4DBB A;  5J3T A;  2I5C A;  3U8Z A;  4HB2 B;  4MT7 A;  1ZM0 A;  2LKO A;  4C0A A;  4HAW B;  2GCJ A;  3TCA A;  2UZR A;  2M38 A;  1WJ1 A;  2DHK A;  1U29 A;  2ELA A;  1DBH A;  2DYN A;  4PNK A;  3MPX A;  3PVU A;  1U5D A;  3BIN A;  2Y8F A;  1TQZ A;  2KUP A;  3G9W A;  2YT1 A;  1X86 A;  1V89 A;  4HAV B;  4P7I A;  1KZ7 A;  2VKI A;  3AJ4 A;  1RJ2 A;  3PVW A;  5HE0 A;  1PLS A;  3GYO A;  2D9V A;  1X11 A;  2J0J A;  5EFX A;  4MK0 A;  5LON B;  3BJI A;  1LB1 A;  4A6F A;  1SGH A;  1K5G B;  2HTH B;  1MIZ B;  3F5R A;  2MFQ A;  3VIA A;  3P7Z A;  3V5W A;  1U2B A;  1OY2 A;  1OQN A;  1FGY A;  1QQG A;  2P0D A;  3DXC A;  2H7D A;  2RUK B;  2Y8G A;  2J59 M;  4A5K A;  4EJN A;  5C5B A;  2NMB A;  2RNR B;  2IFS A;  3PZD A;  3KRX A;  2LOX A;  2DKQ A;  4IFS A;  4A6H A;  3FEH A;  1BTK A;  1Y5O A;  1UNR A;  2CAY A;  2ZPY A;  4DXA B;  1DYN A;  2YS1 A;  4KHB B;  4TYZ A;  1Q67 A;  2P0F A;  5KQ4 A;  4A6F B;  3SUZ A;  1MK7 B;  1I2H A;  1FB8 A;  1MPH A;  1J0W A;  1PMS A;  3QBV B;  1NTY A;  2MDX A;  1BTN A;  4IAP A;  3WYF B;  5JLJ B;  4KVG B;  2N0Y A;  4B6H A;  5DH9 B;  1WGU A;  5KQ1 A;  2R0D A;  3CXB B;  2G35 A;  4PQ0 A;  3KSY A;  1UPQ A;  5LOP B;  3TVV A;  1U27 A;  4CHM A;  4BBK A;  2DHI A;  2XQN M;  3TO1 A;  2COA A;  3TFM A;  4EMO A;  2YS3 A;  4HHV A;  1MKE A;  2D4Q A;  1N3H A;  2DFK A;  1QC6 A;  2RGN B;  1KZG A;  1ZC4 B;  4NY0 A;  2H7E A;  3SYX A;  2J0K A;  1P5T A;  3P6A A;  1MAI A;  4F7G A;  3D8D A;  4GPT B;  4A6K A;  4GZU A;  3FM8 C;  1MK9 B;  4F7U P;  2L1C A;  1XR0 B;  4TKN A;  4ZRI A;  2QKM A;  1NI2 A;  2DN6 A;  5JHH A;  1W1H A;  3NSU A;  1AQC A;  1NTV A;  1X1G A;  5JHG A;  3ZDT A;  1U5E A;  3DXE A;  1FGZ A;  1UEF A;  3SV1 A;  3KRW A;  2CY4 A;  1H10 A;  2UZS A;  5C79 A;  1DDM A;  1WGQ A;  2LYD A;  2YS5 A;  1P3R A;  2EC1 A;  2VRW B;  3U7D A;  2V76 A;  5CLQ B;  3ULB A;  2BCJ A;  4HAX B;  4K2O A;  2YSZ A;  4IOY X;  3AU4 A;  4ZRJ A;  1EGX A;  5D27 A;  1EAZ A;  2UVM A;  5FI1 A;  1V61 A;  4HAT B;  5D3Y A;  1BWN A;  2D10 A;  2DTC A;  2QKL A;  4DX9 0;  1UPR A;  4K2P A;  2P0H A;  1MIX A;  3PP2 A;  2KGX B;  5KCV A;  2K00 A;  5DIF B;  2COF A;  3M1I B;  2DYQ A;  5J3Y A;  2LUL A;  2EMT A;  3ODW A;  2D11 A;  3HQC A;  4HAY B;  1WG7 A;  1LW3 A;  2Z0P A;  3VOQ A;  2MWN B;  3OAN A;  3HK0 A;  4GMX B;  3X23 A;  2OTX A;  2D9Y A;  1EVH A;  2Z0O A;  1NU2 A;  1V5P A;  4HDQ A;  4HB0 B;  1V5M A;  1GC6 A;  2Z0Q A;  1W1G A;  2ROZ B;  4L6E A;  2DLW A;  3SNH A;  4Z2N A;  4HAU B;  5HE3 A;  2YVC A;  3CIK A;  2ROV A;  4MY6 A;  2AEH A;  4WJ7 A;  3MDB C;  1FHO A;  2YF0 A;  4CHJ A;  3D8F A;  1TXD A;  2ELB A;  2JP2 A;  1FAO A; 
#chains in the Genus database with same CATH topology
 2L2I A;  2RLO A;  4K17 A;  2LG1 A;  2KCJ A;  1XX0 A;  1RRP B;  1ZC3 B;  4ZRK A;  3IVF A;  4GXB A;  3A98 B;  3LJU X;  2D9W A;  2IYB A;  4K81 A;  4WVF B;  5HE2 A;  4GMV A;  5CLL B;  2EJ8 A;  1WVH A;  1EF1 A;  4QJ3 B;  4KAX B;  5FI0 A;  1V5U A;  4QJ5 B;  1SHC A;  3ML4 A;  1E5W A;  2D9Z A;  2CY5 A;  4WSF A;  4XWX A;  2K8E A;  2I1K A;  3PG7 A;  3F0W A;  2YRY A;  2RVB B;  1GG3 A;  2OQB A;  3PEG A;  2E2X A;  5DHA B;  1X1F A;  4YON A;  2Q13 A;  2DKP A;  3QIJ A;  4DIX A;  2P8V A;  2HE7 A;  1XCG A;  3TW1 A;  1BAK A;  3ODX A;  1KI1 B;  1FOE A;  2EMS A;  4H8S A;  2NZ8 B;  5DHF B;  2RSG A;  1UNP A;  1TJ6 A;  5D3X A;  2VSZ A;  1Y19 B;  2COC A;  2K49 A;  2MKR A;  2D2Q A;  4D0N B;  1DDV A;  3N7C A;  2ADZ A;  1XD4 A;  2LOZ A;  4Y94 A;  3QWM A;  5D3W A;  5D3V A;  1ISN A;  5L81 A;  1PFJ A;  3O96 A;  3ODO A;  5J3Q A;  1J19 A;  3WA0 A;  2KR0 A;  3FSS A;  3AU5 A;  2K2U A;  2FJL A;  3B77 A;  3KY9 A;  3PSC A;  1U5G A;  1XKE A;  4YL8 A;  4HB3 B;  4HDO A;  4OSN A;  2Y7B A;  2COD A;  2N23 A;  1M7E A;  1OMW A;  3ULC A;  5HE1 A;  2W2X D;  2DX5 A;  3T06 A;  4GN1 A;  5LG4 B;  4EKU A;  1FHX A;  2DA0 A;  5C16 A;  1B55 A;  1DDW A;  3OHM B;  4CYE A;  2W2X C;  4KHA A;  2GS0 A;  1DRO A;  4GOU A;  2M14 A;  1K5D B;  3KZ1 A;  2D9X A;  1H4R A;  4Z2M B;  3D8E A;  2I5F A;  2DX1 A;  1AWE A;  4QXA B;  1ZSQ A;  2YT0 A;  5DI9 B;  3HW2 B;  1IRS A;  1X05 A;  2R09 A;  3PVL A;  1P6S A;  4NSW A;  1WI1 A;  4KHO A;  2I1J A;  1XOD A;  3RCP A;  3A8Q A;  5I2M A;  3NWD A;  3ZVR A;  1ZVR A;  2PZ1 A;  3NW8 A;  2W2W A;  2ZKM X;  3GYP A;  1GC7 A;  1WJM A;  2FJU B;  1M7R A;  3U12 A;  1U5F A;  1I7A A;  1W1D A;  2J0M A;  2AL6 A;  5C5B B;  2GJY A;  1Z87 A;  1V88 A;  2K2J A;  5C6R A;  3DCX A;  2X18 A;  4HB4 B;  3UZT A;  2CRF A;  5GOW B;  3A8P A;  5JP4 A;  1FHW A;  2GCL A;  4F7H A;  4HAZ B;  3DXD A;  4DX8 A;  2DHJ A;  1UNQ A;  5IRS A;  3SO6 A;  4DBB A;  5J3T A;  2I5C A;  3U8Z A;  2GUM A;  3A58 A;  4HB2 B;  4MT7 A;  1ZM0 A;  2LKO A;  4C0A A;  4HAW B;  2GCJ A;  3TCA A;  2UZR A;  2M38 A;  2YT2 A;  1WJ1 A;  2DHK A;  1U29 A;  2ELA A;  1DBH A;  5I2S A;  2DYN A;  4PNK A;  3MPX A;  3PVU A;  1U5D A;  3BIN A;  2Y8F A;  1TQZ A;  2KUP A;  3G9W A;  2YT1 A;  1X86 A;  1V89 A;  4HAV B;  4P7I A;  4GNK B;  1KZ7 A;  2Z14 A;  2VKI A;  5M4Y B;  3HSA A;  3AJ4 A;  1RJ2 A;  3PVW A;  5HE0 A;  1PLS A;  3GYO A;  2D9V A;  1X11 A;  2J0J A;  5EFX A;  4MK0 A;  5LON B;  3NWA A;  3BJI A;  1LB1 A;  4A6F A;  1SGH A;  1K5G B;  2HTH B;  1MIZ B;  3F5R A;  2MFQ A;  3VIA A;  3P7Z A;  3V5W A;  1U2B A;  1OY2 A;  1OQN A;  1FGY A;  1QQG A;  2P0D A;  3DXC A;  2H7D A;  2RUK B;  2Y8G A;  2J59 M;  4A5K A;  4EJN A;  5C5B A;  2NMB A;  2RNR B;  2IFS A;  3PZD A;  3KRX A;  2LOX A;  2DKQ A;  4IFS A;  4A6H A;  3FEH A;  1BTK A;  1Y5O A;  1UNR A;  2CAY A;  2ZPY A;  4DXA B;  1DYN A;  2YS1 A;  4KHB B;  4TYZ A;  1Q67 A;  2P0F A;  5KQ4 A;  4A6F B;  3SUZ A;  1MK7 B;  3FVC A;  1I2H A;  1FB8 A;  1MPH A;  1J0W A;  1PMS A;  3QBV B;  1NTY A;  1MI1 A;  2MDX A;  1BTN A;  4IAP A;  3WYF B;  5JLJ B;  4KVG B;  1ZYI A;  2N0Y A;  4B6H A;  2Z4D A;  5DH9 B;  1WGU A;  5KQ1 A;  2R0D A;  3CXB B;  2G35 A;  4PQ0 A;  3KSY A;  1UPQ A;  5LOP B;  3TVV A;  3NWF A;  2Z59 A;  1U27 A;  4CHM A;  4BBK A;  2DHI A;  2XQN M;  3TO1 A;  2COA A;  3TFM A;  4EMO A;  2YS3 A;  4HHV A;  1MKE A;  2D4Q A;  1N3H A;  2DFK A;  2RRF A;  2R2Y A;  1QC6 A;  2RGN B;  1KZG A;  1ZC4 B;  4NY0 A;  2H7E A;  3SYX A;  2J0K A;  4QJ4 B;  1P5T A;  3P6A A;  1MAI A;  4F7G A;  3D8D A;  4GPT B;  4A6K A;  2KUQ A;  4GZU A;  3FM8 C;  1MK9 B;  4F7U P;  2L1C A;  1XR0 B;  4TKN A;  4ZRI A;  2QKM A;  1NI2 A;  2DN6 A;  5JHH A;  1W1H A;  3NSU A;  1AQC A;  1NTV A;  1X1G A;  5JHG A;  3ZDT A;  1U5E A;  3DXE A;  1FGZ A;  1UEF A;  3SV1 A;  3KRW A;  2CY4 A;  1H10 A;  4KHB A;  2UZS A;  5C79 A;  1DDM A;  1WGQ A;  2LYD A;  2YS5 A;  1P3R A;  2EC1 A;  2NBV A;  2VRW B;  3U7D A;  2V76 A;  5CLQ B;  2Z13 A;  2BCJ A;  3ULB A;  4HAX B;  4K2O A;  2KIE A;  2YSZ A;  4IOY X;  3AU4 A;  4ZRJ A;  1EGX A;  4HSI A;  5D27 A;  1EAZ A;  2UVM A;  5FI1 A;  1V61 A;  4HAT B;  5D3Y A;  4L1R A;  1BWN A;  2D10 A;  4CSQ A;  2DTC A;  2QKL A;  4DX9 0;  1UPR A;  4K2P A;  2P0H A;  1MIX A;  3PP2 A;  2KGX B;  5KCV A;  2K00 A;  5DIF B;  2COF A;  3M1I B;  2DYQ A;  5J3Y A;  2LUL A;  2EMT A;  3ODW A;  2D11 A;  3HQC A;  4HAY B;  1WG7 A;  1LW3 A;  2KIG A;  2Z0P A;  3VOQ A;  2MWN B;  3OAN A;  3HK0 A;  4GMX B;  3X23 A;  2OTX A;  2D9Y A;  1EVH A;  2Z0O A;  1NU2 A;  1V5P A;  1T77 A;  4HDQ A;  4HB0 B;  1V5M A;  1GC6 A;  2Z0Q A;  1W1G A;  2ROZ B;  4L6E A;  4D6W A;  2DLW A;  3SNH A;  4Z2N A;  4HAU B;  5HE3 A;  4OT1 A;  2YVC A;  3CIK A;  2ROV A;  4MY6 A;  2AEH A;  4WJ7 A;  3MDB C;  1FHO A;  2YF0 A;  3HIE A;  4CHJ A;  3D8F A;  1TXD A;  2ELB A;  2JP2 A;  1FAO A; 
#chains in the Genus database with same CATH homology
 2L2I A;  2RLO A;  4K17 A;  2LG1 A;  2KCJ A;  1XX0 A;  1RRP B;  1ZC3 B;  4ZRK A;  3IVF A;  4GXB A;  3A98 B;  3LJU X;  2D9W A;  2IYB A;  4K81 A;  4WVF B;  5HE2 A;  4GMV A;  5CLL B;  2EJ8 A;  1WVH A;  1EF1 A;  4KAX B;  5FI0 A;  1V5U A;  1SHC A;  3ML4 A;  1E5W A;  2D9Z A;  2CY5 A;  4WSF A;  4XWX A;  2I1K A;  3PG7 A;  3F0W A;  2YRY A;  2RVB B;  1GG3 A;  2OQB A;  3PEG A;  2E2X A;  5DHA B;  1X1F A;  4YON A;  2Q13 A;  2DKP A;  3QIJ A;  2P8V A;  2HE7 A;  1XCG A;  3TW1 A;  1BAK A;  3ODX A;  1KI1 B;  1FOE A;  2EMS A;  4H8S A;  2NZ8 B;  5DHF B;  2RSG A;  1UNP A;  1TJ6 A;  5D3X A;  2VSZ A;  1Y19 B;  2COC A;  2MKR A;  2D2Q A;  4D0N B;  1DDV A;  3N7C A;  2ADZ A;  1XD4 A;  2LOZ A;  4Y94 A;  3QWM A;  5D3W A;  5D3V A;  1ISN A;  5L81 A;  1PFJ A;  3O96 A;  3ODO A;  5J3Q A;  1J19 A;  3WA0 A;  3FSS A;  3AU5 A;  2K2U A;  2FJL A;  3KY9 A;  3PSC A;  1U5G A;  1XKE A;  4YL8 A;  4HB3 B;  4HDO A;  2Y7B A;  2COD A;  2N23 A;  1M7E A;  1OMW A;  3ULC A;  5HE1 A;  2W2X D;  2DX5 A;  3T06 A;  4GN1 A;  4EKU A;  1FHX A;  2DA0 A;  5C16 A;  1B55 A;  1DDW A;  4CYE A;  2W2X C;  4KHA A;  2GS0 A;  1DRO A;  2M14 A;  1K5D B;  3KZ1 A;  2D9X A;  1H4R A;  4Z2M B;  3D8E A;  2I5F A;  2DX1 A;  1AWE A;  1ZSQ A;  2YT0 A;  5DI9 B;  3HW2 B;  1IRS A;  1X05 A;  2R09 A;  3PVL A;  1P6S A;  4NSW A;  1WI1 A;  4KHO A;  2I1J A;  1XOD A;  3RCP A;  3A8Q A;  3ZVR A;  1ZVR A;  2PZ1 A;  2W2W A;  3GYP A;  1GC7 A;  1WJM A;  1M7R A;  1U5F A;  1I7A A;  1W1D A;  2J0M A;  2AL6 A;  5C5B B;  2GJY A;  1Z87 A;  1V88 A;  2K2J A;  5C6R A;  2X18 A;  4HB4 B;  3UZT A;  2CRF A;  5GOW B;  3A8P A;  5JP4 A;  1FHW A;  2GCL A;  4F7H A;  4HAZ B;  3DXD A;  4DX8 A;  2DHJ A;  1UNQ A;  3SO6 A;  4DBB A;  5J3T A;  2I5C A;  3U8Z A;  4HB2 B;  4MT7 A;  1ZM0 A;  2LKO A;  4C0A A;  4HAW B;  2GCJ A;  3TCA A;  2UZR A;  2M38 A;  1WJ1 A;  2DHK A;  1U29 A;  2ELA A;  1DBH A;  2DYN A;  4PNK A;  3MPX A;  3PVU A;  1U5D A;  3BIN A;  2Y8F A;  1TQZ A;  2KUP A;  3G9W A;  2YT1 A;  1X86 A;  1V89 A;  4HAV B;  4P7I A;  1KZ7 A;  2VKI A;  3AJ4 A;  1RJ2 A;  3PVW A;  5HE0 A;  1PLS A;  3GYO A;  2D9V A;  1X11 A;  2J0J A;  5EFX A;  4MK0 A;  5LON B;  3BJI A;  1LB1 A;  4A6F A;  1SGH A;  1K5G B;  2HTH B;  1MIZ B;  3F5R A;  2MFQ A;  3VIA A;  3P7Z A;  3V5W A;  1U2B A;  1OY2 A;  1OQN A;  1FGY A;  1QQG A;  2P0D A;  3DXC A;  2H7D A;  2RUK B;  2Y8G A;  2J59 M;  4A5K A;  4EJN A;  5C5B A;  2NMB A;  2RNR B;  2IFS A;  3PZD A;  3KRX A;  2LOX A;  2DKQ A;  4IFS A;  4A6H A;  3FEH A;  1BTK A;  1Y5O A;  1UNR A;  2CAY A;  2ZPY A;  4DXA B;  1DYN A;  2YS1 A;  4KHB B;  4TYZ A;  1Q67 A;  2P0F A;  5KQ4 A;  4A6F B;  3SUZ A;  1MK7 B;  1I2H A;  1FB8 A;  1MPH A;  1J0W A;  1PMS A;  3QBV B;  1NTY A;  2MDX A;  1BTN A;  4IAP A;  3WYF B;  5JLJ B;  4KVG B;  2N0Y A;  4B6H A;  5DH9 B;  1WGU A;  5KQ1 A;  2R0D A;  3CXB B;  2G35 A;  4PQ0 A;  3KSY A;  1UPQ A;  5LOP B;  3TVV A;  1U27 A;  4CHM A;  4BBK A;  2DHI A;  2XQN M;  3TO1 A;  2COA A;  3TFM A;  4EMO A;  2YS3 A;  4HHV A;  1MKE A;  2D4Q A;  1N3H A;  2DFK A;  1QC6 A;  2RGN B;  1KZG A;  1ZC4 B;  4NY0 A;  2H7E A;  3SYX A;  2J0K A;  1P5T A;  3P6A A;  1MAI A;  4F7G A;  3D8D A;  4GPT B;  4A6K A;  4GZU A;  3FM8 C;  1MK9 B;  4F7U P;  2L1C A;  1XR0 B;  4TKN A;  4ZRI A;  2QKM A;  1NI2 A;  2DN6 A;  5JHH A;  1W1H A;  3NSU A;  1AQC A;  1NTV A;  1X1G A;  5JHG A;  3ZDT A;  1U5E A;  3DXE A;  1FGZ A;  1UEF A;  3SV1 A;  3KRW A;  2CY4 A;  1H10 A;  2UZS A;  5C79 A;  1DDM A;  1WGQ A;  2LYD A;  2YS5 A;  1P3R A;  2EC1 A;  2VRW B;  3U7D A;  2V76 A;  5CLQ B;  3ULB A;  2BCJ A;  4HAX B;  4K2O A;  2YSZ A;  4IOY X;  3AU4 A;  4ZRJ A;  1EGX A;  5D27 A;  1EAZ A;  2UVM A;  5FI1 A;  1V61 A;  4HAT B;  5D3Y A;  1BWN A;  2D10 A;  2DTC A;  2QKL A;  4DX9 0;  1UPR A;  4K2P A;  2P0H A;  1MIX A;  3PP2 A;  2KGX B;  5KCV A;  2K00 A;  5DIF B;  2COF A;  3M1I B;  2DYQ A;  5J3Y A;  2LUL A;  2EMT A;  3ODW A;  2D11 A;  3HQC A;  4HAY B;  1WG7 A;  1LW3 A;  2Z0P A;  3VOQ A;  2MWN B;  3OAN A;  3HK0 A;  4GMX B;  3X23 A;  2OTX A;  2D9Y A;  1EVH A;  2Z0O A;  1NU2 A;  1V5P A;  4HDQ A;  4HB0 B;  1V5M A;  1GC6 A;  2Z0Q A;  1W1G A;  2ROZ B;  4L6E A;  2DLW A;  3SNH A;  4Z2N A;  4HAU B;  5HE3 A;  2YVC A;  3CIK A;  2ROV A;  4MY6 A;  2AEH A;  4WJ7 A;  3MDB C;  1FHO A;  2YF0 A;  4CHJ A;  3D8F A;  1TXD A;  2ELB A;  2JP2 A;  1FAO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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