1ZYIA

Solution structure of icln, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
116
structure length
116
Chain Sequence
QQQPETEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDLNAYPREHLYVMVNAKFGEESKESVAEEEDSDDDVEPIAEFRFVPSDKSALEAMFTAMCECQAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4
pubmed doi rcsb
molecule tags Translation
source organism Canis lupus familiaris
molecule keywords Methylosome subunit pICln
total genus 14
structure length 116
sequence length 116
ec nomenclature
pdb deposition date 2005-06-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.60 Mainly Beta Roll PH-domain like PH-domain like 1zyiA00
1ZYIA
chains in the Genus database with same CATH superfamily
3KSYA 2RRFA 4HAXB 3HW2B 1U5DA 3PP2A 4HAUB 3F5RA 4EKUA 3BJIA 1ZC3B 5JHHA 2LOXA 1OQNA 5FI0A 1SGHA 1XCGA 1WJ1A 2EC1A 3DXEA 1UEFA 4C0AA 4QJ4B 3KY9A 4F7UP 1WG7A 2YS5A 2K2UA 2ELBA 2Z0PA 1B55A 2ROZB 1PLSA 3CXBB 4D0NB 1W1DA 3SUZA 2AL6A 2R0DA 2FJUB 4OT1A 2RNRB 2E2XA 1FB8A 2UVMA 2W2XD 2RLOA 3PEGA 4WVFB 5C5BB 3ZVRA 1UNRA 4HHVA 2QKMA 1V5UA 2EMTA 1W1GA 5GOWB 2XQNM 3O96A 3QIJA 1DDVA 1GG3A 4KAXB 2I5CA 5HE2A 1EAZA 2IYBA 2N23A 4BBKA 4P7IA 4QJ5B 1MAIA 4GMXB 1DDWA 1KZGA 4GXBA 3SO6A 2W2WA 1T77A 2VKIA 2Y7BA 1TJ6A 1NTYA 4TYZA 3GYOA 1BTKA 1ZC4B 1Z87A 2DLWA 1W1HA 1N3HA 1X86A 5D3WA 2D2QA 2ZPYA 4MT7A 2YT1A 1P3RA 5CLLB 4EMOA 1EGXA 1FGZA 2LULA 2D9WA 3RCPA 1QQGA 2CAYA 2R2YA 2YT0A 4HSIA 4PQ0A 4ZRJA 4ZRIA 1Y5OA 1K5GB 1V88A 3HK0A 4HAVB 5IRSA 5I2SA 3U8ZA 2COCA 4L1RA 1XD4A 5M4YB 3QBVB 1GC7A 1M7EA 1V5PA 1FOEA 3ODOA 5DH9B 2Y8FA 5DI9B 2MFQA 5LOPB 1ZM0A 2LOZA 4IFSA 2P0DA 5D3XA 1WVHA 3PVLA 2KCJA 2Z4DA 4DX90 2BCJA 2CRFA 4GPTB 2KR0A 3QWMA 4NY0A 2LYDA 1E5WA 3OHMB 3PVUA 2K00A 4MY6A 3ULCA 4TKNA 4KHBB 1BAKA 2LKOA 1MK7B 5DIFB 5JLJB 4NSWA 1UPRA 4IOYX 1Y19B 1TQZA 5HE1A 2DKPA 1V61A 2D9ZA 2YS1A 3TO1A 4F7GA 2YRYA 3HSAA 2M14A 2YVCA 3D8DA 2DA0A 2K49A 4K81A 5CLQB 2NZ8B 1LB1A 4HATB 4HB4B 5I2MA 4CHMA 5D27A 2MKRA 1MKEA 3NWAA 4YONA 2JP2A 3AJ4A 5KCVA 1QC6A 2Z14A 2MDXA 2EMSA 3SV1A 4A6FA 1PFJA 2GJYA 2VSZA 1RRPB 1MI1A 3NWFA 2DKQA 2GCJA 5HE3A 3B77A 2N0YA 2ADZA 4WJ7A 2NMBA 2COFA 2J59M 1XKEA 4HAWB 4KHBA 5DHFB 3D8FA 1EVHA 3WA0A 1DROA 2RVBB 4HB2B 1P6SA 4HAYB 1MK9B 3KZ1A 3CIKA 2D9VA 2EJ8A 4HAZB 4CYEA 1MIXA 3A8PA 3PSCA 4GNKB 1FHWA 4XWXA 1WI1A 4A5KA 2Z0OA 2Z59A 5C6RA 1WGQA 3PZDA 2Z0QA 4Y94A 2DX1A 1GC6A 2J0MA 2D9XA 2DYNA 3DCXA 4A6HA 1FGYA 1H10A 1WJMA 3BINA 1XODA 2KUPA 1RJ2A 4GN1A 2M38A 1MPHA 1U29A 2UZRA 5D3VA 2K2JA 4K17A 4EJNA 3ODWA 1DYNA 2PZ1A 3ODXA 4IAPA 2CY4A 3TVVA 1FHOA 1U5GA 3KRWA 5JHGA 2DFKA 4MK0A 2KGXB 2MWNB 4A6FB 5C79A 3AU4A 1U5FA 4H8SA 1AWEA 3TFMA 5EFXA 1KI1B 5D3YA 1NTVA 5LONB 3TCAA 4L6EA 2DX5A 3P6AA 1U2BA 3HIEA 2DHIA 3P7ZA 4GOUA 2Z13A 3ZDTA 2DTCA 4CSQA 1ISNA 1IRSA 4K2OA 4DIXA 4F7HA 4QJ3B 2I1JA 5JP4A 4Z2NA 1X05A 4K2PA 3KRXA 3ML4A 4Z2MB 1BTNA 3TW1A 1K5DB 1ZVRA 2RSGA 4DXAB 3FM8C 3U7DA 1EF1A 1Q67A 2R09A 3V5WA 1PMSA 2DHKA 2RGNB 3D8EA 3DXCA 1NI2A 3IVFA 4A6KA 2ROVA 3GYPA 2KIEA 2L1CA 2KIGA 2GS0A 2J0KA 1XX0A 3AU5A 5C16A 3NSUA 1J0WA 3MPXA 1AQCA 3U12A 3MDBC 4HB0B 1KZ7A 1LW3A 4D6WA 2IFSA 5J3YA 4HDQA 3FEHA 2YF0A 4WSFA 2LG1A 2FJLA 1UPQA 2DYQA 3VOQA 5FI1A 4CHJA 1U5EA 2W2XC 2YT2A 2ELAA 5DHAB 2OTXA 2I1KA 1DDMA 4KHAA 3UZTA 3N7CA 4GMVA 2D10A 1J19A 5KQ1A 2D11A 1DBHA 2Y8GA 2DHJA 2CY5A 1ZYIA 3DXDA 1X1GA 1M7RA 3A98B 2ZKMX 4QXAB 2HTHB 5LG4B 2V76A 3X23A 5L81A 1UNQA 2X18A 4OSNA 2P0HA 2COAA 3T06A 5J3QA 2GCLA 3PVWA 3NWDA 4DX8A 5HE0A 2J0JA 1NU2A 2P0FA 1OMWA 1MIZB 2I5FA 3A8QA 2YS3A 2OQBA 2L2IA 2CODA 2QKLA 3PG7A 4GZUA 4HB3B 4YL8A 4KVGB 1UNPA 1U27A 1X1FA 3HQCA 1SHCA 3NW8A 2K8EA 2P8VA 5J3TA 1OY2A 3WYFB 1XR0B 2YSZA 1FHXA 3FSSA 1TXDA 2GUMA 4PNKA 1FAOA 3FVCA 1ZSQA 3M1IB 2D9YA 1I7AA 3VIAA 3ULBA 2VRWB 1H4RA 1WGUA 2Q13A 4KHOA 3LJUX 1V89A 2G35A 3OANA 3SYXA 4B6HA 3F0WA 3G9WA 5C5BA 1BWNA 2AEHA 2H7EA 4HDOA 3SNHA 4DBBA 2UZSA 2D4QA 1P5TA 2H7DA 1I2HA 5KQ4A 2NBVA 2RUKB 2DN6A 3A58A 4ZRKA 1V5MA 1X11A 2HE7A 2KUQA
chains in the Genus database with same CATH topology
3TO1A 2RRFA 4GNKB 3NWFA 1ZYIA 4KHOA 4CSQA 4KHBB 4DIXA 2Z59A 3TVVA 2ZKMX 3GYPA 4QXAB 2YT2A 4QJ3B 2KIEA 2K49A 5LG4B 4IFSA 2KIGA 4Z2NA 2FJUB 4OT1A 3NW8A 4QJ5B 4Z2MB 2K8EA 5I2MA 4OSNA 2R2YA 4HSIA 4PQ0A 4IOYX 2Z4DA 3TW1A 3NWAA 2NBVA 4KHBA 4KHAA 3U12A 2KR0A 2GCLA 3FSSA 3GYOA 4QJ4B 5IRSA 4D6WA 2GUMA 3NWDA 5I2SA 4L1RA 2Z14A 3A58A 3FVCA 4GOUA 3HIEA 5M4YB 2Z13A 2GCJA 3OHMB 2KUQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZYI A; 
#chains in the Genus database with same CATH topology
 3KSY A;  2RRF A;  4HAX B;  3HW2 B;  1U5D A;  3PP2 A;  4HAU B;  3F5R A;  4EKU A;  3BJI A;  1ZC3 B;  5JHH A;  2LOX A;  1OQN A;  5FI0 A;  1SGH A;  1XCG A;  1WJ1 A;  2EC1 A;  3DXE A;  1UEF A;  4C0A A;  4QJ4 B;  3KY9 A;  4F7U P;  1WG7 A;  2YS5 A;  2K2U A;  2ELB A;  2Z0P A;  1B55 A;  2ROZ B;  1PLS A;  3CXB B;  4D0N B;  1W1D A;  3SUZ A;  2AL6 A;  2R0D A;  2FJU B;  4OT1 A;  2RNR B;  2E2X A;  1FB8 A;  2UVM A;  2W2X D;  2RLO A;  3PEG A;  4WVF B;  5C5B B;  3ZVR A;  1UNR A;  4HHV A;  2QKM A;  1V5U A;  2EMT A;  1W1G A;  5GOW B;  2XQN M;  3O96 A;  3QIJ A;  1DDV A;  1GG3 A;  4KAX B;  2I5C A;  5HE2 A;  1EAZ A;  2IYB A;  2N23 A;  4BBK A;  4P7I A;  4QJ5 B;  1MAI A;  4GMX B;  1DDW A;  1KZG A;  4GXB A;  3SO6 A;  2W2W A;  1T77 A;  2VKI A;  2Y7B A;  1TJ6 A;  1NTY A;  4TYZ A;  3GYO A;  1BTK A;  1ZC4 B;  1Z87 A;  2DLW A;  1W1H A;  1N3H A;  1X86 A;  5D3W A;  2D2Q A;  2ZPY A;  4MT7 A;  2YT1 A;  1P3R A;  5CLL B;  4EMO A;  1EGX A;  1FGZ A;  2LUL A;  2D9W A;  3RCP A;  1QQG A;  2CAY A;  2R2Y A;  2YT0 A;  4HSI A;  4PQ0 A;  4ZRJ A;  4ZRI A;  1Y5O A;  1K5G B;  1V88 A;  3HK0 A;  4HAV B;  5IRS A;  5I2S A;  3U8Z A;  2COC A;  4L1R A;  1XD4 A;  5M4Y B;  3QBV B;  1GC7 A;  1M7E A;  1V5P A;  1FOE A;  3ODO A;  5DH9 B;  2Y8F A;  5DI9 B;  2MFQ A;  5LOP B;  1ZM0 A;  2LOZ A;  4IFS A;  2P0D A;  5D3X A;  1WVH A;  3PVL A;  2KCJ A;  2Z4D A;  4DX9 0;  2BCJ A;  2CRF A;  4GPT B;  2KR0 A;  3QWM A;  4NY0 A;  2LYD A;  1E5W A;  3OHM B;  3PVU A;  2K00 A;  4MY6 A;  3ULC A;  4TKN A;  4KHB B;  1BAK A;  2LKO A;  1MK7 B;  5DIF B;  5JLJ B;  4NSW A;  1UPR A;  4IOY X;  1Y19 B;  1TQZ A;  5HE1 A;  2DKP A;  1V61 A;  2D9Z A;  2YS1 A;  3TO1 A;  4F7G A;  2YRY A;  3HSA A;  2M14 A;  2YVC A;  3D8D A;  2DA0 A;  2K49 A;  4K81 A;  5CLQ B;  2NZ8 B;  1LB1 A;  4HAT B;  4HB4 B;  5I2M A;  4CHM A;  5D27 A;  2MKR A;  1MKE A;  3NWA A;  4YON A;  2JP2 A;  3AJ4 A;  5KCV A;  1QC6 A;  2Z14 A;  2MDX A;  2EMS A;  3SV1 A;  4A6F A;  1PFJ A;  2GJY A;  2VSZ A;  1RRP B;  1MI1 A;  3NWF A;  2DKQ A;  2GCJ A;  5HE3 A;  3B77 A;  2N0Y A;  2ADZ A;  4WJ7 A;  2NMB A;  2COF A;  2J59 M;  1XKE A;  4HAW B;  4KHB A;  5DHF B;  3D8F A;  1EVH A;  3WA0 A;  1DRO A;  2RVB B;  4HB2 B;  1P6S A;  4HAY B;  1MK9 B;  3KZ1 A;  3CIK A;  2D9V A;  2EJ8 A;  4HAZ B;  4CYE A;  1MIX A;  3A8P A;  3PSC A;  4GNK B;  1FHW A;  4XWX A;  1WI1 A;  4A5K A;  2Z0O A;  2Z59 A;  5C6R A;  1WGQ A;  3PZD A;  2Z0Q A;  4Y94 A;  2DX1 A;  1GC6 A;  2J0M A;  2D9X A;  2DYN A;  3DCX A;  4A6H A;  1FGY A;  1H10 A;  1WJM A;  3BIN A;  1XOD A;  2KUP A;  1RJ2 A;  4GN1 A;  2M38 A;  1MPH A;  1U29 A;  2UZR A;  5D3V A;  2K2J A;  4K17 A;  4EJN A;  3ODW A;  1DYN A;  2PZ1 A;  3ODX A;  4IAP A;  2CY4 A;  3TVV A;  1FHO A;  1U5G A;  3KRW A;  5JHG A;  2DFK A;  4MK0 A;  2KGX B;  2MWN B;  4A6F B;  5C79 A;  3AU4 A;  1U5F A;  4H8S A;  1AWE A;  3TFM A;  5EFX A;  1KI1 B;  5D3Y A;  1NTV A;  5LON B;  3TCA A;  4L6E A;  2DX5 A;  3P6A A;  1U2B A;  3HIE A;  2DHI A;  3P7Z A;  4GOU A;  2Z13 A;  3ZDT A;  2DTC A;  4CSQ A;  1ISN A;  1IRS A;  4K2O A;  4DIX A;  4F7H A;  4QJ3 B;  2I1J A;  5JP4 A;  4Z2N A;  1X05 A;  4K2P A;  3KRX A;  3ML4 A;  4Z2M B;  1BTN A;  3TW1 A;  1K5D B;  1ZVR A;  2RSG A;  4DXA B;  3FM8 C;  3U7D A;  1EF1 A;  1Q67 A;  2R09 A;  3V5W A;  1PMS A;  2DHK A;  2RGN B;  3D8E A;  3DXC A;  1NI2 A;  3IVF A;  4A6K A;  2ROV A;  3GYP A;  2KIE A;  2L1C A;  2KIG A;  2GS0 A;  2J0K A;  1XX0 A;  3AU5 A;  5C16 A;  3NSU A;  1J0W A;  3MPX A;  1AQC A;  3U12 A;  3MDB C;  4HB0 B;  1KZ7 A;  1LW3 A;  4D6W A;  2IFS A;  5J3Y A;  4HDQ A;  3FEH A;  2YF0 A;  4WSF A;  2LG1 A;  2FJL A;  1UPQ A;  2DYQ A;  3VOQ A;  5FI1 A;  4CHJ A;  1U5E A;  2W2X C;  2YT2 A;  2ELA A;  5DHA B;  2OTX A;  2I1K A;  1DDM A;  4KHA A;  3UZT A;  3N7C A;  4GMV A;  2D10 A;  1J19 A;  5KQ1 A;  2D11 A;  1DBH A;  2Y8G A;  2DHJ A;  2CY5 A;  1ZYI A;  3DXD A;  1X1G A;  1M7R A;  3A98 B;  2ZKM X;  4QXA B;  2HTH B;  5LG4 B;  2V76 A;  3X23 A;  5L81 A;  1UNQ A;  2X18 A;  4OSN A;  2P0H A;  2COA A;  3T06 A;  5J3Q A;  2GCL A;  3PVW A;  3NWD A;  4DX8 A;  5HE0 A;  2J0J A;  1NU2 A;  2P0F A;  1OMW A;  1MIZ B;  2I5F A;  3A8Q A;  2YS3 A;  2OQB A;  2L2I A;  2COD A;  2QKL A;  3PG7 A;  4GZU A;  4HB3 B;  4YL8 A;  4KVG B;  1UNP A;  1U27 A;  1X1F A;  3HQC A;  1SHC A;  3NW8 A;  2K8E A;  2P8V A;  5J3T A;  1OY2 A;  3WYF B;  1XR0 B;  2YSZ A;  1FHX A;  3FSS A;  1TXD A;  2GUM A;  4PNK A;  1FAO A;  3FVC A;  1ZSQ A;  3M1I B;  2D9Y A;  1I7A A;  3VIA A;  3ULB A;  2VRW B;  1H4R A;  1WGU A;  2Q13 A;  4KHO A;  3LJU X;  1V89 A;  2G35 A;  3OAN A;  3SYX A;  4B6H A;  3F0W A;  3G9W A;  5C5B A;  1BWN A;  2AEH A;  2H7E A;  4HDO A;  3SNH A;  4DBB A;  2UZS A;  2D4Q A;  1P5T A;  2H7D A;  1I2H A;  5KQ4 A;  2NBV A;  2RUK B;  2DN6 A;  3A58 A;  4ZRK A;  1V5M A;  1X11 A;  2HE7 A;  2KUQ A; 
#chains in the Genus database with same CATH homology
 3TO1 A;  2RRF A;  4GNK B;  3NWF A;  1ZYI A;  4KHO A;  4CSQ A;  4KHB B;  4DIX A;  2Z59 A;  3TVV A;  2ZKM X;  3GYP A;  4QXA B;  2YT2 A;  4QJ3 B;  2KIE A;  2K49 A;  5LG4 B;  4IFS A;  2KIG A;  4Z2N A;  2FJU B;  4OT1 A;  3NW8 A;  4QJ5 B;  4Z2M B;  2K8E A;  5I2M A;  4OSN A;  2R2Y A;  4HSI A;  4PQ0 A;  4IOY X;  2Z4D A;  3TW1 A;  3NWA A;  2NBV A;  4KHB A;  4KHA A;  3U12 A;  2KR0 A;  2GCL A;  3FSS A;  3GYO A;  4QJ4 B;  5IRS A;  4D6W A;  2GUM A;  3NWD A;  5I2S A;  4L1R A;  2Z14 A;  3A58 A;  3FVC A;  4GOU A;  3HIE A;  5M4Y B;  2Z13 A;  2GCJ A;  3OHM B;  2KUQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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